PE20070713A1 - 4-amino-5-cloro-n-{[1-(tetrahidro-2h-piran-4-ilmetil)-4-piperidinil]metil}-1-benzofuran-7-carboxamida en el tratamiento de alzheimer - Google Patents
4-amino-5-cloro-n-{[1-(tetrahidro-2h-piran-4-ilmetil)-4-piperidinil]metil}-1-benzofuran-7-carboxamida en el tratamiento de alzheimerInfo
- Publication number
- PE20070713A1 PE20070713A1 PE2006001310A PE2006001310A PE20070713A1 PE 20070713 A1 PE20070713 A1 PE 20070713A1 PE 2006001310 A PE2006001310 A PE 2006001310A PE 2006001310 A PE2006001310 A PE 2006001310A PE 20070713 A1 PE20070713 A1 PE 20070713A1
- Authority
- PE
- Peru
- Prior art keywords
- benzofuran
- pyran
- carboxamide
- tetrahydro
- chloro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE REFIERE A UN COMPUESTO DE 4-AMINO-5-CLORO-N-{[1-(TETRAHIDRO-2H-PIRAN-4-ILMETIL)-4-PIPERIDINIL]METIL}-1-BENZOFURAN-7-CARBOXAMIDA Y SUS SALES DE TOSILATO, TOSILATO MONOHIDRATO, TOSILATO ANHIDRO. REFERIDA TAMBIEN A UN PROCEDIMIENTO DE PREPARACION QUE COMPRENDE: A) REACCIONAR 4-AMINO-5-CLORO-N-(4-PIPERIDINILMETIL)-1-BENZOFURAN-7-CARBOXAMIDA O UNA SAL O DERIVADO PROTEGIDO DE LA MISMA CON TETRAHIDRO-2H-PIRAN-4-CARBALDEHIDO; B) DESPROTEGER EL COMPUESTO; C) FORMAR LA SAL FARMACEUTICA. DICHOS COMPUESTOS SON AGONISTAS DEL RECEPTOR 5-HT4, UTILES EN EL TRATAMIENTO DE ALZHEIMER
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0522071A GB0522071D0 (en) | 2005-10-28 | 2005-10-28 | Novel compound |
GB0619950A GB0619950D0 (en) | 2006-10-09 | 2006-10-09 | Novel compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20070713A1 true PE20070713A1 (es) | 2007-09-27 |
Family
ID=37591731
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2006001310A PE20070713A1 (es) | 2005-10-28 | 2006-10-26 | 4-amino-5-cloro-n-{[1-(tetrahidro-2h-piran-4-ilmetil)-4-piperidinil]metil}-1-benzofuran-7-carboxamida en el tratamiento de alzheimer |
Country Status (4)
Country | Link |
---|---|
AR (1) | AR056729A1 (es) |
PE (1) | PE20070713A1 (es) |
TW (1) | TW200732327A (es) |
WO (1) | WO2007048643A1 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011092293A2 (en) | 2010-02-01 | 2011-08-04 | Novartis Ag | Cyclohexyl amide derivatives as crf receptor antagonists |
EP2531510B1 (en) | 2010-02-01 | 2014-07-23 | Novartis AG | Pyrazolo[5,1b]oxazole derivatives as crf-1 receptor antagonists |
ES2527849T3 (es) | 2010-02-02 | 2015-01-30 | Novartis Ag | Derivados de ciclohexilamida como antagonistas del receptor de CRF |
ME03430B (me) * | 2015-02-13 | 2020-01-20 | Suven Life Sciences Ltd | Jedinjenja amida kao agonisti 5-ht4 receptora |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0820586A (ja) * | 1994-07-05 | 1996-01-23 | Sanwa Kagaku Kenkyusho Co Ltd | 1−アザビシクロ[3.3.0]オクタン誘導体、その塩及び製法並びに用途 |
WO2005092882A1 (en) * | 2004-03-01 | 2005-10-06 | Pfizer Japan, Inc. | 4-amino-5-halogeno-benzamide derivatives as 5-ht4 receptor agonists for the treatment of gastrointestinal, cns, neurological and cardiovascular disorders |
-
2006
- 2006-10-26 TW TW095139451A patent/TW200732327A/zh unknown
- 2006-10-26 WO PCT/EP2006/010438 patent/WO2007048643A1/en active Application Filing
- 2006-10-26 PE PE2006001310A patent/PE20070713A1/es not_active Application Discontinuation
- 2006-10-26 AR ARP060104683A patent/AR056729A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
AR056729A1 (es) | 2007-10-17 |
WO2007048643A1 (en) | 2007-05-03 |
TW200732327A (en) | 2007-09-01 |
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