PE20070357A1 - PROCESO PARA LA PREPARACION DE INHIBIDORES DE ß-LACTAMASA - Google Patents

PROCESO PARA LA PREPARACION DE INHIBIDORES DE ß-LACTAMASA

Info

Publication number
PE20070357A1
PE20070357A1 PE2006001012A PE2006001012A PE20070357A1 PE 20070357 A1 PE20070357 A1 PE 20070357A1 PE 2006001012 A PE2006001012 A PE 2006001012A PE 2006001012 A PE2006001012 A PE 2006001012A PE 20070357 A1 PE20070357 A1 PE 20070357A1
Authority
PE
Peru
Prior art keywords
preparation
compound
lactamase inhibitors
formula
penem
Prior art date
Application number
PE2006001012A
Other languages
English (en)
Inventor
Ronald S Michalak
Rocco Galante
David Michael Blum
Lisa Routel
Haris Durutlic
Charles Guinosso
John Considine
Kenneth KREMER
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of PE20070357A1 publication Critical patent/PE20070357A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE REFERIERE A UN PROCEDIMIENTO DE PREPARACION DE UN COMPUESTO DE FORMULA II, DONDE A' ES 1, 2, 3; Z1, Z2, Z3, Z4, Z5, Y Z6 SON CADA UNO N, S, O,NH, ENTRE OTROS; Y1, Y2, Y3 SON CADA UNO C, N; W1, W2 Y W3 SON CADA UNO S, SO, NH, O, ENTRE OTROS; t ES 1-4. DICHO COMPUESTO SE CONDENSA CON UN 6-BROMO-PENEM, EN CONDICIONES EFECTIVAS Y LUEGO SE LLEVA A CABO UNA AMINACION REDUCTIVA OBTENIENDO EL COMPUESTO DE FORMULA I, DONDE R5 ES H, ALQUILO C1-C6, CICLOALQUILO C5-C6, ENTRE OTROS; A Y B JUNTOS SON A'. DICHOS COMPUESTOS SON INHIBIDORES DE B-LACTAMASA DE AMPLIO ESPECTRO Y AGENTES BACTERIANOS
PE2006001012A 2005-08-24 2006-08-22 PROCESO PARA LA PREPARACION DE INHIBIDORES DE ß-LACTAMASA PE20070357A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US71095705P 2005-08-24 2005-08-24

Publications (1)

Publication Number Publication Date
PE20070357A1 true PE20070357A1 (es) 2007-04-20

Family

ID=37716038

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006001012A PE20070357A1 (es) 2005-08-24 2006-08-22 PROCESO PARA LA PREPARACION DE INHIBIDORES DE ß-LACTAMASA

Country Status (13)

Country Link
US (1) US20070149499A1 (es)
EP (1) EP1917270A2 (es)
JP (1) JP2009507784A (es)
CN (1) CN101277964A (es)
AR (1) AR057767A1 (es)
AU (1) AU2006283207A1 (es)
BR (1) BRPI0615083A2 (es)
CA (1) CA2619368A1 (es)
GT (1) GT200600380A (es)
MX (1) MX2008002570A (es)
PE (1) PE20070357A1 (es)
TW (1) TW200745139A (es)
WO (1) WO2007024859A2 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8188083B2 (en) 2007-06-28 2012-05-29 Abbott Laboratories Triazolopyridazines
US20100063023A1 (en) * 2008-09-10 2010-03-11 Wyeth Bicyclic and Tricyclic Substituted 6-Methylidene Carbapenems as Broad Spectrum Beta-Lactamase Inhibitors
US20110288063A1 (en) * 2010-05-19 2011-11-24 Naeja Pharmaceutical Inc. Novel fused bridged bicyclic heteroaryl substituted 6-alkylidene penems as potent beta-lactamase inhibitors

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4206067A (en) * 1978-10-02 1980-06-03 Chevron Research Company Thermally stabilized erosion-inhibited functional fluids containing perhalometal compounds and an organic base
DE3176517D1 (en) * 1980-04-24 1987-12-17 Beecham Group Plc Beta-lactam compounds, their preparation and use
US4891369A (en) * 1986-12-03 1990-01-02 Taiho Pharmaceutical Company, Limited 2β-Substituted-methylpenicillanic acid derivatives, and salts and esters thereof
GB8724566D0 (en) * 1987-10-20 1987-11-25 Roussel Lab Ltd Chemical compounds
ES2206502T3 (es) * 1994-04-25 2004-05-16 Smithkline Beecham Plc Formulaciones farmaceuticas que contienen un penem inhibidor de beta-lactamasa en combinacion con un antibiotico de beta-lactama y su uso en el tratamiento de infecciones bacterianas.
EP1143952B1 (en) * 1998-10-15 2003-02-26 Sarawak Medichem Pharmaceuticals Inc. Method and composition for treating and preventing tuberculosis
GB9928290D0 (en) * 1999-12-01 2000-01-26 Univ Belfast Process for preparing ambient temperature ionic liquids
AR039475A1 (es) * 2002-05-01 2005-02-23 Wyeth Corp 6-alquiliden-penems triciclicos como inhibidores de beta-lactamasa
AR039476A1 (es) * 2002-05-01 2005-02-23 Wyeth Corp Proceso para preparar derivados de 6-alquiliden penem
AR039774A1 (es) * 2002-05-01 2005-03-02 Wyeth Corp 6-alquiliden-penems biciclicos como inhibidores de beta-lactamasas
US20040132708A1 (en) * 2002-05-01 2004-07-08 Wyeth Process for preparing 6-alkylidene penem derivatives
AR046041A1 (es) * 2003-10-03 2005-11-23 Aventis Pharma Inc Procedimiento para la preparacion de compuestos heterociclicos n-amino sustituidos

Also Published As

Publication number Publication date
CA2619368A1 (en) 2007-03-01
TW200745139A (en) 2007-12-16
BRPI0615083A2 (pt) 2011-05-03
JP2009507784A (ja) 2009-02-26
AR057767A1 (es) 2007-12-19
WO2007024859A2 (en) 2007-03-01
EP1917270A2 (en) 2008-05-07
MX2008002570A (es) 2008-03-18
GT200600380A (es) 2007-03-29
WO2007024859A3 (en) 2007-06-21
CN101277964A (zh) 2008-10-01
US20070149499A1 (en) 2007-06-28
AU2006283207A1 (en) 2007-03-01

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Legal Events

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