PE20070357A1 - PROCESO PARA LA PREPARACION DE INHIBIDORES DE ß-LACTAMASA - Google Patents

PROCESO PARA LA PREPARACION DE INHIBIDORES DE ß-LACTAMASA

Info

Publication number
PE20070357A1
PE20070357A1 PE2006001012A PE2006001012A PE20070357A1 PE 20070357 A1 PE20070357 A1 PE 20070357A1 PE 2006001012 A PE2006001012 A PE 2006001012A PE 2006001012 A PE2006001012 A PE 2006001012A PE 20070357 A1 PE20070357 A1 PE 20070357A1
Authority
PE
Peru
Prior art keywords
preparation
compound
lactamase inhibitors
formula
penem
Prior art date
Application number
PE2006001012A
Other languages
English (en)
Inventor
Ronald S Michalak
Rocco Galante
David Michael Blum
Lisa Routel
Haris Durutlic
Charles Guinosso
John Considine
Kenneth KREMER
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of PE20070357A1 publication Critical patent/PE20070357A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE REFERIERE A UN PROCEDIMIENTO DE PREPARACION DE UN COMPUESTO DE FORMULA II, DONDE A' ES 1, 2, 3; Z1, Z2, Z3, Z4, Z5, Y Z6 SON CADA UNO N, S, O,NH, ENTRE OTROS; Y1, Y2, Y3 SON CADA UNO C, N; W1, W2 Y W3 SON CADA UNO S, SO, NH, O, ENTRE OTROS; t ES 1-4. DICHO COMPUESTO SE CONDENSA CON UN 6-BROMO-PENEM, EN CONDICIONES EFECTIVAS Y LUEGO SE LLEVA A CABO UNA AMINACION REDUCTIVA OBTENIENDO EL COMPUESTO DE FORMULA I, DONDE R5 ES H, ALQUILO C1-C6, CICLOALQUILO C5-C6, ENTRE OTROS; A Y B JUNTOS SON A'. DICHOS COMPUESTOS SON INHIBIDORES DE B-LACTAMASA DE AMPLIO ESPECTRO Y AGENTES BACTERIANOS
PE2006001012A 2005-08-24 2006-08-22 PROCESO PARA LA PREPARACION DE INHIBIDORES DE ß-LACTAMASA PE20070357A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US71095705P 2005-08-24 2005-08-24

Publications (1)

Publication Number Publication Date
PE20070357A1 true PE20070357A1 (es) 2007-04-20

Family

ID=37716038

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006001012A PE20070357A1 (es) 2005-08-24 2006-08-22 PROCESO PARA LA PREPARACION DE INHIBIDORES DE ß-LACTAMASA

Country Status (13)

Country Link
US (1) US20070149499A1 (es)
EP (1) EP1917270A2 (es)
JP (1) JP2009507784A (es)
CN (1) CN101277964A (es)
AR (1) AR057767A1 (es)
AU (1) AU2006283207A1 (es)
BR (1) BRPI0615083A2 (es)
CA (1) CA2619368A1 (es)
GT (1) GT200600380A (es)
MX (1) MX2008002570A (es)
PE (1) PE20070357A1 (es)
TW (1) TW200745139A (es)
WO (1) WO2007024859A2 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009005675A1 (en) 2007-06-28 2009-01-08 Abbott Laboratories Novel triazolopyridazines
US20100063023A1 (en) * 2008-09-10 2010-03-11 Wyeth Bicyclic and Tricyclic Substituted 6-Methylidene Carbapenems as Broad Spectrum Beta-Lactamase Inhibitors
US20110288063A1 (en) * 2010-05-19 2011-11-24 Naeja Pharmaceutical Inc. Novel fused bridged bicyclic heteroaryl substituted 6-alkylidene penems as potent beta-lactamase inhibitors

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4206067A (en) * 1978-10-02 1980-06-03 Chevron Research Company Thermally stabilized erosion-inhibited functional fluids containing perhalometal compounds and an organic base
DE3176517D1 (en) * 1980-04-24 1987-12-17 Beecham Group Plc Beta-lactam compounds, their preparation and use
US4891369A (en) * 1986-12-03 1990-01-02 Taiho Pharmaceutical Company, Limited 2β-Substituted-methylpenicillanic acid derivatives, and salts and esters thereof
GB8724566D0 (en) * 1987-10-20 1987-11-25 Roussel Lab Ltd Chemical compounds
AU690685B2 (en) * 1994-04-25 1998-04-30 Smithkline Beecham Plc Pharmaceutical formulations containing a beta-lactamase inhibiting penem in combination with a beta-lactam antibiotic and their use in the treatment of bacterial infections
CA2346813A1 (en) * 1998-10-15 2000-04-20 Sarawak Medichem Pharmaceuticals Incorporated Method and composition for treating and preventing tuberculosis
GB9928290D0 (en) * 1999-12-01 2000-01-26 Univ Belfast Process for preparing ambient temperature ionic liquids
AR039475A1 (es) * 2002-05-01 2005-02-23 Wyeth Corp 6-alquiliden-penems triciclicos como inhibidores de beta-lactamasa
AR039774A1 (es) * 2002-05-01 2005-03-02 Wyeth Corp 6-alquiliden-penems biciclicos como inhibidores de beta-lactamasas
AR039476A1 (es) * 2002-05-01 2005-02-23 Wyeth Corp Proceso para preparar derivados de 6-alquiliden penem
US20040132708A1 (en) * 2002-05-01 2004-07-08 Wyeth Process for preparing 6-alkylidene penem derivatives
AR046041A1 (es) * 2003-10-03 2005-11-23 Aventis Pharma Inc Procedimiento para la preparacion de compuestos heterociclicos n-amino sustituidos

Also Published As

Publication number Publication date
AR057767A1 (es) 2007-12-19
AU2006283207A1 (en) 2007-03-01
CN101277964A (zh) 2008-10-01
WO2007024859A2 (en) 2007-03-01
JP2009507784A (ja) 2009-02-26
TW200745139A (en) 2007-12-16
CA2619368A1 (en) 2007-03-01
EP1917270A2 (en) 2008-05-07
MX2008002570A (es) 2008-03-18
GT200600380A (es) 2007-03-29
WO2007024859A3 (en) 2007-06-21
BRPI0615083A2 (pt) 2011-05-03
US20070149499A1 (en) 2007-06-28

Similar Documents

Publication Publication Date Title
EA200870321A1 (ru) Способ получения 4-оксохинолинового соединения
PE20070009A1 (es) Tigeciclina y metodos para su preparacion
SG164384A1 (en) Novel heterocyclic compound or salt thereof and intermediate thereof
TW200716583A (en) Crystal forms of {[(2R)-7-(2,6-dichlorophenyl)-5-fluoro-2,3-dihydro-1-benzofuran-2-yl]methyl}amine hydrochloride
TR201903663T4 (tr) Ari̇loazol-2-i̇l si̇yanoeti̇lamino bi̇leşi̇kleri̇, bunlarin oluşturulmasi yöntemi̇ ve bunlarin kullanilmasi yöntemi̇.
MXPA05009969A (es) Metodo para aislar la forma cristalina i de la 5-azacitidina.
NZ592382A (en) Thioamide compounds, method of making and method of using thereof
NO20083207L (no) Inhibitorer av IAP
BRPI0518459A2 (pt) composto ou um sal farmaceuticamente aceitÁvel do mesmo, composiÇço farmacÊutica, uso de um composto, e, processo para preparar o composto ou um sal farmaceuticamente aceitÁvel do mesmo
BRPI0516911A (pt) método para a preparação de um composto e composto de anilina
MX2010002258A (es) Compuestos terapeuticos de isoxazol.
AR075084A1 (es) Metodo de preparacion de quinolinil -oxidifenil - ciclopropanodicarboxamidas e intermediarios correspondientes
BRPI0507495A (pt) composto, composição farmacêutica, uso do composto método para o tratamento de distúrbios mediados por mglur5, e, método para inibir a ativação de receptores de mglur5
PE20090601A1 (es) Derivados de piridin-il-oxi-piridinas como inhibidores de alk5
NO20076145L (no) Ureadeviater, fremgangsmater for deres fremstilling og anvendelse derav
NO20064344L (no) Caspaseinhibitorer og anvendelser derav
EA200700931A1 (ru) Новые производные дикарбоновых кислот
WO2007068417A3 (en) Process for the preparation of amines
EA200600605A1 (ru) Перегруппированные пентанолы, способ их получения и их применение в качестве противовоспалительных средств
NO20064884L (no) Kjemisk fremgangsmate og ny krystallinsk form
EA200700550A1 (ru) Производные алкилидентетрагидронафталина, способ их получения и их применение в качестве противовоспалительных средств
TW200613308A (en) Cyclobutanetetracarboxylate compound and preparation method thereof
UA85701C2 (ru) Способ получения ингибиторов триптазы
AR047810A1 (es) Proceso quimico
PE20080929A1 (es) Metodos para el tratamiento de la depresion

Legal Events

Date Code Title Description
FD Application declared void or lapsed