PE20061197A1 - TRICYCLIC AMINOALCOHOLS, AS INHIBITORS OF IL-8 CYTOKINE SECRETION - Google Patents

TRICYCLIC AMINOALCOHOLS, AS INHIBITORS OF IL-8 CYTOKINE SECRETION

Info

Publication number
PE20061197A1
PE20061197A1 PE2006000009A PE2006000009A PE20061197A1 PE 20061197 A1 PE20061197 A1 PE 20061197A1 PE 2006000009 A PE2006000009 A PE 2006000009A PE 2006000009 A PE2006000009 A PE 2006000009A PE 20061197 A1 PE20061197 A1 PE 20061197A1
Authority
PE
Peru
Prior art keywords
alkyl
inhibitors
hexahidrobenzo
trifluoromethyl
cycloalkyl
Prior art date
Application number
PE2006000009A
Other languages
Spanish (es)
Inventor
Markus Berger
Norbert Schmees
Stefan Baurle
Anne Mengel
Danja Grossbach
David Voigtlander
Konrand Krolikiewicz
Hartmut Rehwinkel
Heike Schacke
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of PE20061197A1 publication Critical patent/PE20061197A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/74—Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/20—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 hydrogenated in the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I DONDE R1 Y R2 SON CADA UNO H, HIDROXI, HALOGENO, ALQUILO C1-C10, ENTRE OTROS; R3 ES H, HIDROXI, HALOGENO, ALQUILTIO C1-C10, ENTRE OTROS; R4 ES ALQUILO C1-C10 SUSTITUIDO O NO, CICLOALQUILO C3-C7, HETEROCICLILO SUSTUITUIDO O NO, ENTRE OTROS; R5 ES ALQUILO C1-C5, CICLOALQUILO C3-C7, (CICLOALQUILO C3-C7)-(ALQUENILO C2-C8), HETEROCICLILO, ENTRE OTROS; R6 Y R7 SON CADA UNO H, HALOGENO, ALQUILO C1-C5 SUSTITUIDO O NO, ENTRE OTROS; p ES 1-3; X ES O, S, CH2, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 6-[(7-FLUORO-2-METILQUINAZOLIN-5-IL)AMINO]-5-(TRIFLUOROMETIL)-2,3,3a,4,5,6-HEXAHIDROBENZO[DE]CROMEN-5-OL; 9-FLUORO-6-[(2-METILQUINOLIN-5-IL)AMINO]-5-(TRIFLUOROMETIL)-2,3,3a,4,5,6-HEXAHIDROBENZO[DE]CROMEN-5-OL; 5-{[5-HIDROXI-5-(TRIFLUOROMETIL)-2,3,3a,4,5,6-HEXAHIDROBENZO[DE]CROMEN-6-IL]AMINO}-2-METILFTALAZIN-1-ONA; ENTRE OTROS. REFERIDA TAMBIEN A UN COMPOSCION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SON INHIBIDORES DE LA SECRESION DE LA CITOQUINA IL-8 PROVOCADA POR LIPOPOLISACARIDOS (LPS) UTILES EN EL TRATAMIENTO DE LA INFLAMACIONREFERS TO A COMPOUND OF FORMULA I WHERE R1 AND R2 ARE EACH H, HYDROXY, HALOGEN, C1-C10 ALKYL, AMONG OTHERS; R3 IS H, HYDROXY, HALOGEN, C1-C10 ALKYLTIO, AMONG OTHERS; R4 IS C1-C10 ALKYL, SUBSTITUTED OR NOT, C3-C7 CYCLOALKYL, HETEROCYCLYL SUBSTITUTE OR NOT, AMONG OTHERS; R5 IS C1-C5 ALKYL, C3-C7 CYCLOALKYL, (C3-C7 CYCLOALKYL) - (C2-C8 ALKENYL), HETEROCYCLYL, AMONG OTHERS; R6 AND R7 ARE EACH H, HALOGEN, C1-C5 ALKYL SUBSTITUTED OR NOT, AMONG OTHERS; p IS 1-3; X IS O, S, CH2, AMONG OTHERS. THE PREFERRED COMPOUNDS ARE: 6 - [(7-FLUORO-2-METHYLQUINAZOLIN-5-IL) AMINO] -5- (TRIFLUORomethyl) -2,3,3a, 4,5,6-HEXAHIDROBENZO [DE] CROMEN-5-OL ; 9-FLUORO-6 - [(2-METHYLQUINOLIN-5-IL) AMINO] -5- (TRIFLUORomethyl) -2,3,3a, 4,5,6-HEXAHIDROBENZO [DE] CHROMEN-5-OL; 5 - {[5-HYDROXY-5- (TRIFLUOROMETHYL) -2,3,3a, 4,5,6-HEXAHIDROBENZO [DE] CHROMEN-6-IL] AMINO} -2-METHYLPHTHALAZIN-1-ONA; AMONG OTHERS. ALSO REFERRED TO A PHARMACEUTICAL COMPOSTION AND A PREPARATION PROCEDURE. SAID COMPOUNDS ARE INHIBITORS OF THE SECTION OF IL-8 CYTOKINE CAUSED BY LIPOPOLYSACCHARIDES (LPS) USEFUL IN THE TREATMENT OF INFLAMMATION

PE2006000009A 2004-12-22 2006-01-03 TRICYCLIC AMINOALCOHOLS, AS INHIBITORS OF IL-8 CYTOKINE SECRETION PE20061197A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102004063227A DE102004063227A1 (en) 2004-12-22 2004-12-22 Tricylic amino alcohols, process for their preparation and their use as anti-inflammatory agents

Publications (1)

Publication Number Publication Date
PE20061197A1 true PE20061197A1 (en) 2006-12-07

Family

ID=36250953

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006000009A PE20061197A1 (en) 2004-12-22 2006-01-03 TRICYCLIC AMINOALCOHOLS, AS INHIBITORS OF IL-8 CYTOKINE SECRETION

Country Status (14)

Country Link
JP (1) JP2008524300A (en)
KR (1) KR20070089948A (en)
CN (1) CN101087780A (en)
AR (1) AR055016A1 (en)
AU (1) AU2005318354A1 (en)
BR (1) BRPI0519710A2 (en)
CA (1) CA2586973A1 (en)
DE (1) DE102004063227A1 (en)
GT (1) GT200500385A (en)
IL (1) IL183060A0 (en)
MX (1) MX2007007420A (en)
PA (1) PA8657801A1 (en)
PE (1) PE20061197A1 (en)
WO (1) WO2006066950A2 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7638515B2 (en) 2003-10-08 2009-12-29 Bayer Schering Pharma Aktiengesellschaft Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents
WO2005034939A1 (en) 2003-10-08 2005-04-21 Schering Aktiengesellschaft 1-amino-2-oxy-substituted tetrahydronaphtalene derivatives, methods for the production thereof, and their use as antiphlogistics
US7662821B2 (en) 2003-10-08 2010-02-16 Bayer Schering Pharma Ag Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents
US20080153859A1 (en) 2004-04-05 2008-06-26 Hartmut Rehwinkel Multiply-substituted tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents
US7402596B2 (en) 2005-03-24 2008-07-22 Renovis, Inc. Bicycloheteroaryl compounds as P2X7 modulators and uses thereof
EP1834948A1 (en) 2006-03-15 2007-09-19 Bayer Schering Pharma Aktiengesellschaft Tetrahydronaphtalene derivatives, methods for the production thereof, and their use as antiinflammatory drugs
TWI464148B (en) 2006-03-16 2014-12-11 Evotec Us Inc Bicycloheteroaryl compounds as p2x7 modulators and uses thereof
EP1917963A1 (en) * 2006-10-31 2008-05-07 Bayer Schering Pharma Aktiengesellschaft Cyclic phenyl-substituted indazols, a process for their production and their use as anti-inflammatory agents
EP2072509A1 (en) 2007-12-18 2009-06-24 Bayer Schering Pharma Aktiengesellschaft 1-Aryl-1H-quinoline-2-ones: process for their production and their use as anti-inflammatory agents
US10189825B2 (en) 2012-02-08 2019-01-29 Sunovion Pharmaceuticals Inc. Heteroaryl compounds and methods of use thereof
CN116283877A (en) 2016-07-29 2023-06-23 赛诺维信制药公司 Compounds, compositions and uses thereof
EA201990399A1 (en) 2016-07-29 2019-07-31 Суновион Фармасьютикалз, Инк. COMPOUNDS, COMPOSITIONS AND THEIR APPLICATION
EA202090414A1 (en) 2017-08-02 2020-05-28 Суновион Фармасьютикалз Инк. COMPOUNDS AND THEIR APPLICATION
AU2020236225A1 (en) 2019-03-14 2021-09-16 Sunovion Pharmaceuticals Inc. Salts of a isochromanyl compound and crystalline forms, processes for preparing, therapeutic uses, and pharmaceutical compositions thereof
KR102462991B1 (en) * 2020-11-02 2022-11-04 한국해양과학기술원 Compound from a Antarctic-Derived Fungal Strains Acremonium sp. SF-7394 and Composition for Anti-Inflammation, Anticancer or Anti-Diabetes Comprising the Same

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10038639A1 (en) * 2000-07-28 2002-02-21 Schering Ag New and known N-aryl 2-hydroxy-omega-arylalkanamide derivatives, useful e.g. for treating inflammatory diseases such as rheumatism
US6903215B2 (en) * 2002-03-26 2005-06-07 Boehringer Ingelheim Pharmaceuticals, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
DE10215316C1 (en) * 2002-04-02 2003-12-18 Schering Ag Quinoline and isoquinoline derivatives, a pharmaceutical agent and their use as anti-inflammatory agents
WO2005034939A1 (en) * 2003-10-08 2005-04-21 Schering Aktiengesellschaft 1-amino-2-oxy-substituted tetrahydronaphtalene derivatives, methods for the production thereof, and their use as antiphlogistics
GB0418045D0 (en) * 2004-08-12 2004-09-15 Glaxo Group Ltd Compounds
DE102004044680B3 (en) * 2004-09-09 2006-06-08 Schering Ag Alkylidene tetrahydronaphthalene derivatives, process for their preparation and their use as anti-inflammatory agents and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
AU2005318354A1 (en) 2006-06-29
WO2006066950A3 (en) 2006-08-17
MX2007007420A (en) 2007-07-17
CN101087780A (en) 2007-12-12
WO2006066950A2 (en) 2006-06-29
CA2586973A1 (en) 2006-06-29
KR20070089948A (en) 2007-09-04
DE102004063227A1 (en) 2006-07-06
AR055016A1 (en) 2007-08-01
GT200500385A (en) 2006-08-03
PA8657801A1 (en) 2006-12-07
BRPI0519710A2 (en) 2009-03-10
JP2008524300A (en) 2008-07-10
IL183060A0 (en) 2007-09-20

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