PE20060819A1 - Compuestos de quinolina como inhibidores de cetp - Google Patents

Compuestos de quinolina como inhibidores de cetp

Info

Publication number
PE20060819A1
PE20060819A1 PE2005001089A PE2005001089A PE20060819A1 PE 20060819 A1 PE20060819 A1 PE 20060819A1 PE 2005001089 A PE2005001089 A PE 2005001089A PE 2005001089 A PE2005001089 A PE 2005001089A PE 20060819 A1 PE20060819 A1 PE 20060819A1
Authority
PE
Peru
Prior art keywords
ethyl
quinoline
dihydro
carboxyl
bis
Prior art date
Application number
PE2005001089A
Other languages
English (en)
Inventor
Mary Theresa Didiuk
Ryan Michael Kelley
Roger Benjamin Ruggeri
David Austen Perry
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of PE20060819A1 publication Critical patent/PE20060819A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE QUINOLINA, CUYOS PREFERIDOS SON: ESTER ISOPROPILICO DEL ACIDO 4-[AMINO-(3,5-BIS-TRIFLUOROMETILFENIL)METIL]-2-ETIL-6-TRIFLUOROMETIL-3,4-DIHIDRO-2H-QUINOLINA-1-CARBOXILICO, ESTER ISOPROPILICO DEL ACIDO (2R,4R,4aS)-4-[AMINO-(3,5-BIS-TRIFLUOROMETILFENIL)METIL]-2-ETIL-6-TRIFLUOROMETIL-3,4-DIHIDRO-2H-QUINOLINA-1-CARBOXILICO, ESTER N-PROPILICO, ISOBUTILICO, ISOPROPILICO O ETILICO DEL ACIDO 4-[AMINO-(3,5-BIS(TRIFLUOROMETILFENIL)METIL]2-CICLOPROPIL-6-TRIFLUOROMETIL-3,4-DIHIDRO-2H-QUINOLINA-1-CARBOXILICO, ESTER ETILICO, N-PROPILICO O ISOBUTILICO DEL ACIDO (2S,4R,4aS)-4-[AMINO-(3,5-BIS(TRIFLUOROMETILFENIL)METIL]-2-ETIL-6-TRIFLUOROMETIL-3,4-DIHIDRO-2H-QUINOLINA-1-CARBOXILICO, ESTER ETILICO DEL ACIDO 4-[AMINO-(3,5-BIS(CLOROFENIL)METIL]2-ETIL-6-TRIFLUOROMETIL-3,4-DIHIDRO-2H-QUINOLINA-1-CARBOXILICO, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA O UN KIT QUE ADEMAS PUEDE COMPRENDER UN SEGUNDO COMPUESTO SELECCIONADO POR UN INHIBIDOR DE LA HMG-CoA, UN MODULADOR DE PPAR, ENTRE OTROS; TAL COMO SIMVASTATINA, LOVASTATINA, PRAVASTATINA, ENTRE OTROS. ESTOS COMPUESTOS SON INHIBIDORES DE LA PROTEINA DE TRANSFERENCIA DE COLESTERIL ESTER (CETP), POR LO QUE SON UTILES EN EL TRATAMIENTO DE ENFERMEDADES EXACERBADAS POR BAJOS NIVELES DE COLESTEROL HDL Y/O ALTOS NIVELES DE LDL Y TRIGLICERIDOS, TALES COMO ATEROSCLEROSIS Y ENFERMEDADES CARDIOVASCULARES
PE2005001089A 2004-09-23 2005-09-20 Compuestos de quinolina como inhibidores de cetp PE20060819A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US61286304P 2004-09-23 2004-09-23

Publications (1)

Publication Number Publication Date
PE20060819A1 true PE20060819A1 (es) 2006-09-02

Family

ID=35511128

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2005001089A PE20060819A1 (es) 2004-09-23 2005-09-20 Compuestos de quinolina como inhibidores de cetp

Country Status (8)

Country Link
US (1) US20070149567A1 (es)
AR (1) AR054085A1 (es)
GT (1) GT200500264A (es)
NL (1) NL1030012C2 (es)
PE (1) PE20060819A1 (es)
TW (1) TW200616964A (es)
UY (1) UY29124A1 (es)
WO (1) WO2006033004A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1556356B1 (en) * 2002-10-21 2006-05-31 Warner-Lambert Company LLC Tetrahydroquinoline derivatives as crth2 antagonists
DK1740591T3 (da) 2004-04-02 2009-10-26 Osi Pharm Inc Heterobicykliske proteinkinaseinhibitorer substitueret med en 6,6-biocyclisk ring
WO2007107843A1 (en) * 2006-03-22 2007-09-27 Pfizer Products Inc. Methods of treatment with cetp inhibitors
MX2011011025A (es) 2009-04-20 2011-11-02 Osi Pharmaceuticals Llc Preparacion de c-piracin-metilaminas.
JP2013538215A (ja) 2010-08-31 2013-10-10 エスエヌユー アールアンドディービー ファウンデーション ＰＰＡＲδアゴニストの胎児再プログラミング用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GT199900147A (es) * 1998-09-17 1999-09-06 1, 2, 3, 4- tetrahidroquinolinas 2-sustituidas 4-amino sustituidas.
CO5271716A1 (es) * 1999-11-30 2003-04-30 Pfizer Prod Inc Cristales de 4- carboxamino 1,2,3,4-tetrahidroquinolina 2- sustituida
EA200501376A1 (ru) * 2003-03-28 2006-04-28 Пфайзер Продактс Инк. Производные 1,2,4-замещённых 1,2,3,4-тетрагидро- и 1,2-дигидрохинолинов и 1,2,3,4-тетрагидрохиноксалина в качестве ингибиторов сетр для лечения атеросклероза и тучности
JP2007507481A (ja) * 2003-09-30 2007-03-29 ファイザー・プロダクツ・インク Ｃｅｔｐ阻害薬及びその代謝産物

Also Published As

Publication number Publication date
TW200616964A (en) 2006-06-01
GT200500264A (es) 2006-06-02
AR054085A1 (es) 2007-06-06
NL1030012C2 (nl) 2006-11-21
NL1030012A1 (nl) 2006-03-27
US20070149567A1 (en) 2007-06-28
WO2006033004A1 (en) 2006-03-30
UY29124A1 (es) 2006-04-28

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