PE20060653A1 - Derivados triciclicos condensados como moduladores del receptor 5-ht1 - Google Patents
Derivados triciclicos condensados como moduladores del receptor 5-ht1Info
- Publication number
- PE20060653A1 PE20060653A1 PE2005000983A PE2005000983A PE20060653A1 PE 20060653 A1 PE20060653 A1 PE 20060653A1 PE 2005000983 A PE2005000983 A PE 2005000983A PE 2005000983 A PE2005000983 A PE 2005000983A PE 20060653 A1 PE20060653 A1 PE 20060653A1
- Authority
- PE
- Peru
- Prior art keywords
- link
- alkyl
- cr9r10
- alcoxy
- bey
- Prior art date
Links
- -1 INDOLYL Chemical class 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 abstract 2
- QWENRTYMTSOGBR-UHFFFAOYSA-N 1H-1,2,3-Triazole Chemical compound C=1C=NNN=1 QWENRTYMTSOGBR-UHFFFAOYSA-N 0.000 abstract 1
- RAXXELZNTBOGNW-UHFFFAOYSA-N 1H-imidazole Chemical compound C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 abstract 1
- NSPMIYGKQJPBQR-UHFFFAOYSA-N 4H-1,2,4-triazole Chemical compound C=1N=CNN=1 NSPMIYGKQJPBQR-UHFFFAOYSA-N 0.000 abstract 1
- 102000035038 5-HT1 receptors Human genes 0.000 abstract 1
- 108091005478 5-HT1 receptors Proteins 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- OAMIYWZONFMNLH-UHFFFAOYSA-N O1CC(=NC2=C1C=CC=C2)C(=O)N Chemical compound O1CC(=NC2=C1C=CC=C2)C(=O)N OAMIYWZONFMNLH-UHFFFAOYSA-N 0.000 abstract 1
- 208000028017 Psychotic disease Diseases 0.000 abstract 1
- 201000001880 Sexual dysfunction Diseases 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 230000003001 depressive effect Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical class [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
- 229940076279 serotonin Drugs 0.000 abstract 1
- 231100000872 sexual dysfunction Toxicity 0.000 abstract 1
- 150000003536 tetrazoles Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Gynecology & Obstetrics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0419315A GB0419315D0 (en) | 2004-08-31 | 2004-08-31 | Compounds |
| GB0507386A GB0507386D0 (en) | 2005-04-12 | 2005-04-12 | Compounds |
| GB0515010A GB0515010D0 (en) | 2005-07-21 | 2005-07-21 | Compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20060653A1 true PE20060653A1 (es) | 2006-09-27 |
Family
ID=35106764
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2005000983A PE20060653A1 (es) | 2004-08-31 | 2005-08-26 | Derivados triciclicos condensados como moduladores del receptor 5-ht1 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20120022056A1 (https=) |
| EP (1) | EP1786822A1 (https=) |
| JP (1) | JP2008511574A (https=) |
| KR (1) | KR20070057885A (https=) |
| CN (1) | CN101048414B (https=) |
| AR (1) | AR053307A1 (https=) |
| AU (1) | AU2005279278A1 (https=) |
| BR (1) | BRPI0514377A (https=) |
| CA (1) | CA2578781A1 (https=) |
| IL (1) | IL181387A (https=) |
| MA (1) | MA28871B1 (https=) |
| MX (1) | MX2007002548A (https=) |
| NO (1) | NO20071326L (https=) |
| NZ (1) | NZ553506A (https=) |
| PE (1) | PE20060653A1 (https=) |
| TW (1) | TW200619221A (https=) |
| WO (1) | WO2006024517A1 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0316915D0 (en) | 2003-07-18 | 2003-08-20 | Glaxo Group Ltd | Compounds |
| US7898642B2 (en) | 2004-04-14 | 2011-03-01 | Asml Netherlands B.V. | Lithographic apparatus and device manufacturing method |
| JP4324221B2 (ja) * | 2005-08-26 | 2009-09-02 | 株式会社医薬分子設計研究所 | Ｐｐａｒアゴニスト活性を有する誘導体 |
| JP2009523820A (ja) * | 2006-01-23 | 2009-06-25 | アミラ ファーマシューティカルス，インコーポレーテッド | ５−リポキシゲナーゼの三環系抑制剤 |
| US7501438B2 (en) | 2006-07-07 | 2009-03-10 | Forest Laboratories Holdings Limited | Pyridoimidazole derivatives |
| CA2662080C (en) | 2006-09-07 | 2012-07-17 | F. Hoffmann-La Roche Ag | A process for the manufacture of snac (salcaprozate sodium) |
| JP2010504367A (ja) | 2006-09-26 | 2010-02-12 | グラクソ グループ リミテッド | 性機能障害、認知障害、精神病性障害、不安、鬱病などを処置するための５ｈｔ１ａ受容体モジュレーターとしての５−｛２−［４−（２−メチル−５−キノリニル）−ｌ−ピペリジニル］エチル｝キノリノン誘導体 |
| AU2008223348A1 (en) * | 2007-03-07 | 2008-09-12 | Alantos Pharmaceuticals Holding, Inc. | Metalloprotease inhibitors containing a heterocyclic moiety |
| EP2070933A1 (en) | 2007-12-07 | 2009-06-17 | Laboratorios del Dr. Esteve S.A. | Tricyclic triazolic compounds |
| GB0800840D0 (en) | 2008-01-17 | 2008-02-27 | Glaxo Group Ltd | Novel salt |
| DK2268644T3 (da) | 2008-03-05 | 2011-10-10 | Boehringer Ingelheim Int | Tricycliske pyridinderivater, medikamenter indeholdende sådanne forbindelser, deres anvendelse og fremgangsmåde til deres fremstilling |
| WO2010111626A2 (en) * | 2009-03-27 | 2010-09-30 | Takeda Pharmaceutical Company Limited | Poly (adp-ribose) polymerase (parp) inhibitors |
| EA201201160A1 (ru) | 2010-02-19 | 2013-04-30 | Бёрингер Ингельхайм Интернациональ Гмбх | Трициклические производные пиридина, лекарственные средства, содержащие такие соединения, их применение и способ их получения |
| AU2011261375B2 (en) | 2010-06-04 | 2016-09-22 | Albany Molecular Research, Inc. | Glycine transporter-1 inhibitors, methods of making them, and uses thereof |
| WO2012154731A1 (en) * | 2011-05-08 | 2012-11-15 | Vanderbilt University | Substituted 1h-pyrrolo[3,2-c]quinolin-4(5h)-one analogs as positive allosteric modulators of the muscarinic acetylcholine receptor m4 |
| JP5947382B2 (ja) | 2011-08-17 | 2016-07-06 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | フロ［３，４−ｃ］キノリン誘導体、このような化合物を含む薬物、それらの使用及びそれらの調製方法 |
| EP2792679A1 (en) * | 2013-04-19 | 2014-10-22 | Laboratorios Del. Dr. Esteve, S.A. | Tricyclic triazolic compounds |
| JP6523267B2 (ja) * | 2013-06-24 | 2019-05-29 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | Ｆｓｈｒの調節剤としてのイミダゾール化合物及びその使用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX9706196A (es) * | 1996-08-14 | 1998-02-28 | Pfizer | Compuestos triciclicos de piperidinilamino como antagonistas de la sustancia p. |
| IL124914A (en) * | 1997-06-26 | 2000-10-31 | Akzo Nobel Nv | Pharmaceutical compositions containing 6-aryl-2,3,5,6-tetrahydroimidazo¬2,1-a¾isoquinoline derivatives and some new such compounds |
| US6919334B2 (en) * | 2002-09-12 | 2005-07-19 | Wyeth | Antidepressant azaheterocyclymethyl derivatives of 4,5-dihydroimidazo[1,4,5-de][1,4]benzoxazine |
| GB0227240D0 (en) * | 2002-11-21 | 2002-12-31 | Glaxo Group Ltd | Compounds |
-
2005
- 2005-08-26 PE PE2005000983A patent/PE20060653A1/es not_active Application Discontinuation
- 2005-08-29 AR ARP050103607A patent/AR053307A1/es not_active Application Discontinuation
- 2005-08-29 AU AU2005279278A patent/AU2005279278A1/en not_active Abandoned
- 2005-08-29 JP JP2007528777A patent/JP2008511574A/ja active Pending
- 2005-08-29 TW TW094129416A patent/TW200619221A/zh unknown
- 2005-08-29 KR KR1020077007190A patent/KR20070057885A/ko not_active Ceased
- 2005-08-29 EP EP05778196A patent/EP1786822A1/en not_active Withdrawn
- 2005-08-29 NZ NZ553506A patent/NZ553506A/en not_active IP Right Cessation
- 2005-08-29 MX MX2007002548A patent/MX2007002548A/es active IP Right Grant
- 2005-08-29 BR BRPI0514377-2A patent/BRPI0514377A/pt not_active IP Right Cessation
- 2005-08-29 CN CN2005800372427A patent/CN101048414B/zh not_active Expired - Fee Related
- 2005-08-29 US US11/574,450 patent/US20120022056A1/en not_active Abandoned
- 2005-08-29 WO PCT/EP2005/009379 patent/WO2006024517A1/en not_active Ceased
- 2005-08-29 CA CA002578781A patent/CA2578781A1/en not_active Abandoned
-
2007
- 2007-02-15 IL IL181387A patent/IL181387A/en not_active IP Right Cessation
- 2007-03-12 NO NO20071326A patent/NO20071326L/no not_active Application Discontinuation
- 2007-03-23 MA MA29771A patent/MA28871B1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20120022056A1 (en) | 2012-01-26 |
| EP1786822A1 (en) | 2007-05-23 |
| WO2006024517A1 (en) | 2006-03-09 |
| IL181387A (en) | 2011-10-31 |
| KR20070057885A (ko) | 2007-06-07 |
| NO20071326L (no) | 2007-05-03 |
| CN101048414A (zh) | 2007-10-03 |
| MA28871B1 (fr) | 2007-09-03 |
| AR053307A1 (es) | 2007-05-02 |
| AU2005279278A1 (en) | 2006-03-09 |
| TW200619221A (en) | 2006-06-16 |
| CA2578781A1 (en) | 2006-03-09 |
| NZ553506A (en) | 2010-02-26 |
| IL181387A0 (en) | 2007-07-04 |
| BRPI0514377A (pt) | 2008-06-24 |
| MX2007002548A (es) | 2007-04-24 |
| CN101048414B (zh) | 2011-09-07 |
| JP2008511574A (ja) | 2008-04-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PE20060653A1 (es) | Derivados triciclicos condensados como moduladores del receptor 5-ht1 | |
| PE20070021A1 (es) | Compuestos triazolopiridinas como antagonistas de receptor canabinoide 1 | |
| PE20060599A1 (es) | DERIVADOS PIRAZOLO-[3,4-d]-PIRIMIDINA COMO INHIBIDORES DE LA ACTIVIDAD DEL RECEPTOR CANNABINOIDE 1 | |
| JP2005525324A5 (https=) | ||
| PE20060010A1 (es) | 2,3,4,5-TETRAHIDRO-1H-BENZO[d]AZEPINAS 6-SUSTITUIDAS COMO AGONISTAS DEL RECEPTOR 5-HT2C | |
| PE20050756A1 (es) | Heterociclicos azabiciclicos como moduladores del receptor cannabinoide | |
| PE20050465A1 (es) | Compuestos derivados de quinuclidina como antagonistas del receptor muscarinico m3 | |
| PE20020366A1 (es) | Derivados de piperazina como ligandos del receptor 5ht2 | |
| PE20090441A1 (es) | DERIVADOS DE IMIDAZO[1,2-a]PIRIDIN-2-ILMETIL PIPERIDINA SUSTITUIDA | |
| PE20060627A1 (es) | Derivados de pirazol condensado como agonistas de los receptores cannabinoides cb1 y/o cb2 | |
| PE20060555A1 (es) | Derivados de pirrol-oxindol como moduladores del receptor de progesterona | |
| ECSP045368A (es) | "antagonistas de los receptores de trombina" | |
| PE20060625A1 (es) | Derivados de benzazepina como antagonistas y/o agonistas del receptor h3 de histamina | |
| JP2006522812A5 (https=) | ||
| PE20081378A1 (es) | Derivados de 1,2,4-triazol como moduladores de mglur5 | |
| EA199700156A1 (ru) | Производные индола как антагонисты рецептора 5-нт | |
| PE20060531A1 (es) | Derivados de piridazin-3-(2h)-ona como inhibidores de la fosfodiesterasa 4 | |
| PE20081850A1 (es) | Derivados ciclizados como inhibidores de la eg-5 | |
| ECSP045367A (es) | "derivados de bencimidazol utiles como antagonistas de histamina h3" | |
| PE20160691A1 (es) | Nuevos derivados de triazolo[4,5-d]pirimidina | |
| ATE293448T1 (de) | Benzo(d)azepin-derivative als 5-ht6-rezeptor- antagonisten | |
| AR049696A1 (es) | Derivados de indol | |
| IE66687B1 (en) | Antimigraine alkoxypyrimidine derivatives | |
| PE20081152A1 (es) | Azaciclilaminas n-sustituidas como antagonistas de histamina-3 | |
| PE20001583A1 (es) | Derivados de la 1-arenosulfonil-2-arilo-pirrolidina y de la piperidina |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |