PE20060382A1 - DERIVATIVES OF 1,1,2,2-TETRA (STRAIGHT) ARYLETHANE OR 1,1,2-TRI (HETERO) CYCLYLETHANE AS INHIBITORS OF THE POTASSIUM CHANNEL - Google Patents
DERIVATIVES OF 1,1,2,2-TETRA (STRAIGHT) ARYLETHANE OR 1,1,2-TRI (HETERO) CYCLYLETHANE AS INHIBITORS OF THE POTASSIUM CHANNELInfo
- Publication number
- PE20060382A1 PE20060382A1 PE2005000858A PE2005000858A PE20060382A1 PE 20060382 A1 PE20060382 A1 PE 20060382A1 PE 2005000858 A PE2005000858 A PE 2005000858A PE 2005000858 A PE2005000858 A PE 2005000858A PE 20060382 A1 PE20060382 A1 PE 20060382A1
- Authority
- PE
- Peru
- Prior art keywords
- inhibitors
- ilethyl
- ring
- cyclylethane
- arylethane
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE A, B Y C SON CADA UNO ARILO Y ANILLO MONOCICLICO NO SATURADO DE 5, 6 MIEMBROS O UN ANILLO BICICLICO NO SATURADO DE 8-10 MIEMBROS CON 1-4 HETEROATOMOS DE N, O, S; D ES ARILO, ANILLO MONOCICLICO NO SATURADO DE 5, 6 MIEMBROS O UN ANILLO BICICLO NO SATURADO DE 8-10 MIEMBROS CON 1-4 HETEROATOMOS DE N, O, S; X E Y SON CADA UNO H, OH, O-(ALQUILO C1-C6), ENTRE OTROS. SON COMPUESTOS PREFERIDOS: (R)-N-{6-[1-(4-FLUOROFENIL)-2,2-DIPIRIDIN-3-ILETIL]PIRIDIN-2-IL}METANOSULFONAMIDA; (S)-N-{6-[1-(6-METOXIPIRIDIN-2-IL)-2,2-DIPRIDIN-3-ILETIL]PIRIDIN-2-IL}METANOSULFONAMIDA; (S)-3-[1-(2-AMINOPIRIMIDIN-4-IL)-2,2-DIPIRIDIN-3-ILETIL]BENZONITRILO; ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SON INHIBIDORES DE CANALES DE POTASIO (Kv1.5) UTILES EN EL TRATAMIENTO DE ARRITMIAS CARDIACAS Y SIMILARESREFERS TO A COMPOUND OF FORMULA I, WHERE A, B AND C ARE EACH A 5, 6-MEMBER, UNSATURATED AYL AND UNSATURATED BICYCLIC RING OR AN 8-10-MEMBER NON-SATURATED BICYCLE RING WITH 1-4 N, O, S HETEROATOMES; D IS ARYL, 5, 6-MEMBER UNSATURATED SINGLE CYCLE RING OR 8-10-MEMBER NON-SATURATED BICYCLE RING WITH 1-4 N, O, S HETEROATOMS; X AND Y ARE EACH H, OH, O- (C1-C6 ALKYL), AMONG OTHERS. PREFERRED COMPOUNDS ARE: (R) -N- {6- [1- (4-FLUOROPHENYL) -2,2-DIPYRIDIN-3-ILETHYL] PYRIDIN-2-IL} METHANOSULFONAMIDE; (S) -N- {6- [1- (6-METHOXYPYRIDIN-2-IL) -2,2-DIPRIDIN-3-ILETHYL] PYRIDIN-2-IL} METHANOSULPHONAMIDE; (S) -3- [1- (2-AMINOPYRIMIDIN-4-IL) -2,2-DIPYRIDIN-3-ILETHYL] BENZONITRILE; AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION AND A PREPARATION PROCEDURE. SUCH COMPOUNDS ARE INHIBITORS OF POTASSIUM CHANNELS (Kv1.5) USEFUL IN THE TREATMENT OF CARDIAC AND SIMILAR ARRHYTHMIAS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US59218104P | 2004-07-29 | 2004-07-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20060382A1 true PE20060382A1 (en) | 2006-05-15 |
Family
ID=35613661
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2005000858A PE20060382A1 (en) | 2004-07-29 | 2005-07-22 | DERIVATIVES OF 1,1,2,2-TETRA (STRAIGHT) ARYLETHANE OR 1,1,2-TRI (HETERO) CYCLYLETHANE AS INHIBITORS OF THE POTASSIUM CHANNEL |
Country Status (15)
| Country | Link |
|---|---|
| KR (1) | KR20070043985A (en) |
| AR (1) | AR049847A1 (en) |
| BR (1) | BRPI0513793A (en) |
| CR (1) | CR8876A (en) |
| EC (1) | ECSP077208A (en) |
| IL (1) | IL180846A0 (en) |
| MA (1) | MA28980B1 (en) |
| MX (1) | MX2007001188A (en) |
| NO (1) | NO20071107L (en) |
| PE (1) | PE20060382A1 (en) |
| RU (1) | RU2344134C2 (en) |
| TW (1) | TW200607493A (en) |
| UA (1) | UA88018C2 (en) |
| WO (1) | WO2006028590A1 (en) |
| ZA (1) | ZA200700477B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012520829A (en) * | 2009-03-18 | 2012-09-10 | メディキュア・インターナショナル・インコーポレーテッド | Tirofiban transdermal pharmaceutical formulation and administration |
| TWI571470B (en) | 2012-06-11 | 2017-02-21 | 必治妥美雅史谷比公司 | Phosphoramidic acid prodrugs |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1911740B1 (en) * | 2002-01-04 | 2013-02-27 | NeuroSearch A/S | Potassium channel modulators |
-
2005
- 2005-07-19 AR ARP050102975A patent/AR049847A1/en unknown
- 2005-07-22 TW TW094125011A patent/TW200607493A/en unknown
- 2005-07-22 PE PE2005000858A patent/PE20060382A1/en not_active Application Discontinuation
- 2005-07-25 KR KR1020077002228A patent/KR20070043985A/en not_active Application Discontinuation
- 2005-07-25 UA UAA200702125A patent/UA88018C2/en unknown
- 2005-07-25 RU RU2007107408/04A patent/RU2344134C2/en not_active IP Right Cessation
- 2005-07-25 BR BRPI0513793-4A patent/BRPI0513793A/en not_active IP Right Cessation
- 2005-07-25 MX MX2007001188A patent/MX2007001188A/en unknown
- 2005-07-25 WO PCT/US2005/026334 patent/WO2006028590A1/en active Application Filing
-
2007
- 2007-01-16 ZA ZA200700477A patent/ZA200700477B/en unknown
- 2007-01-21 IL IL180846A patent/IL180846A0/en unknown
- 2007-01-25 CR CR8876A patent/CR8876A/en not_active Application Discontinuation
- 2007-01-26 EC EC2007007208A patent/ECSP077208A/en unknown
- 2007-02-21 MA MA29689A patent/MA28980B1/en unknown
- 2007-02-27 NO NO20071107A patent/NO20071107L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| KR20070043985A (en) | 2007-04-26 |
| CR8876A (en) | 2007-08-28 |
| MA28980B1 (en) | 2007-11-01 |
| MX2007001188A (en) | 2007-03-21 |
| IL180846A0 (en) | 2007-06-03 |
| ECSP077208A (en) | 2007-02-28 |
| RU2007107408A (en) | 2008-09-10 |
| RU2344134C2 (en) | 2009-01-20 |
| UA88018C2 (en) | 2009-09-10 |
| WO2006028590A1 (en) | 2006-03-16 |
| ZA200700477B (en) | 2009-08-26 |
| NO20071107L (en) | 2007-04-19 |
| TW200607493A (en) | 2006-03-01 |
| BRPI0513793A (en) | 2008-05-13 |
| AR049847A1 (en) | 2006-09-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR045595A1 (en) | USEFUL COMPOSITIONS AS INHIBITORS OF KINASE PROTEINS | |
| GT200500102A (en) | ORTOSUSTITUTED ARIL-O-HETEROARILAMIDE COMPOUNDS | |
| TW200608969A (en) | Heterocyclic boronic acid compounds | |
| PE20071061A1 (en) | CARBONYL DERIVATIVES AS PEPTIDYL-DEFORMYLASE INHIBITORS (PDF) | |
| PE20061436A1 (en) | DERIVATIVES OF AMIDE SUBSTITUTED AS PROTEIN KINASE INHIBITORS | |
| PE20060777A1 (en) | INDOLINONE DERIVATIVES FOR THE TREATMENT OR PREVENTION OF FIBROTIC DISEASES | |
| CY1112921T1 (en) | Pyrrolidinone Glucokinase Activators | |
| PE20140690A1 (en) | BENZOXAZEPINONES FUSED AS ION CHANNEL MODULATORS | |
| ATE487715T1 (en) | TRIAZOLE DERIVATIVES AS MODULATORS OF DOPAMINE D3 RECEPTORS | |
| EA200800760A1 (en) | PYRIDOPYRIMIDINONE INHIBITORS PI3Kα | |
| EA201200669A1 (en) | PYRIDOPYRIMIDINONE INHIBITORS PI3Kα | |
| ES2368594T3 (en) | SUBSTITUTED DERIVATIVES OF CYCLOHEXILMETILO. | |
| PE20090511A1 (en) | IMIDAZOPYRIDINONES | |
| PE20070367A1 (en) | SPIROPIPERIDINE COMPOUNDS AS INHIBITORS OF THE BETA SECRETASE ENZYME | |
| ATE435855T1 (en) | COMPOUNDS HAVING AGONISTIC ACTION ON THE BETA2-ADRENERGIC RECEPTOR AND THE MUSCARINIC RECEPTOR | |
| EA200700099A1 (en) | PYRIDINE DERIVATIVES | |
| EA200701114A1 (en) | AZOL DERIVATIVES WITH ANTIMUSCARIN ACTIVITY | |
| AR047076A1 (en) | PIRROLOTRIAZINE COMPOUNDS AS THYROSINE KINASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS | |
| DE602006019221D1 (en) | OF DOPAMINE D3 RECEPTORS | |
| TW200505920A (en) | Organic compounds | |
| PE20081850A1 (en) | CYCLIZED DERIVATIVES AS EG-5 INHIBITORS | |
| PE20070016A1 (en) | N-LINKED HETEROCYCLIC COMPOUNDS AS ANTAGONISTS OF THE P2Y1 RECEIVER | |
| EA200700901A1 (en) | DERIVATIVES 2-AMIDO-4-PHENYL THIAZOLE, THEIR OBTAINING AND USE IN THERAPY | |
| ES2328496T3 (en) | 1,4,8-TRIAZA-ESPIRO (4,5) DECAN-2-ONA SUBSTITUTED COMPOUNDS. | |
| EA201070804A1 (en) | (AZA) INDOL DERIVATIVE, SUBSTITUTED BY SITUATION 5, CONTAINING ITS PHARMACEUTICAL COMPOSITION, INTERMEDIATE COMPOUNDS AND METHOD FOR THEIR PRODUCTION |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |