PE20050582A1 - QUINOLONE DERIVATIVES AS ANTIBACTERIAL AGENTS - Google Patents

QUINOLONE DERIVATIVES AS ANTIBACTERIAL AGENTS

Info

Publication number
PE20050582A1
PE20050582A1 PE2004001119A PE2004001119A PE20050582A1 PE 20050582 A1 PE20050582 A1 PE 20050582A1 PE 2004001119 A PE2004001119 A PE 2004001119A PE 2004001119 A PE2004001119 A PE 2004001119A PE 20050582 A1 PE20050582 A1 PE 20050582A1
Authority
PE
Peru
Prior art keywords
cyane
pyrrolidin
cyclopropyl
dihydro
oxo
Prior art date
Application number
PE2004001119A
Other languages
Spanish (es)
Inventor
Edmund Lee Ellsworth
Denton Wade Hoyer
Kim Marie Hutchings
Clarke Bentley Taylor
Sean Timothy Murphy
Mark Ryan Rauckhorst
Jeremy Tyson Starr
Chris Limberakis
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of PE20050582A1 publication Critical patent/PE20050582A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE REFIERE A DERIVADOS DE QUINOLONA DE FORMULA I DONDE X ES N, C CON LA CONDICION DE QUE CUANDO X SEA N, R5 ESTE AUSENTE EN ESA POSICION; R1 ES ALQUILO (C1-C6), HALO-ALQUILO (C1-C6), CICLOALQUILO (C1-C6), HALO-CICLOALQUILO (C3-C6), HETEROCICLILO, ARILO, HETEROARILO, ENTRE OTROS; R2 ES OH, OBF2, O-ALQUILO (C1-C6), O-CICLOALQUILO (C3-C6), ENTRE OTROS; R3, R4 Y R5 SON H, OH, HALO, NRyRz DONDE CADA UNO DE Ry Y Rz ES INDEPENDIENTEMENTE H O ALQUILO (C1-C6); R1 Y R5 TOMADOS JUNTO CON LOS CARBONOS A LOS QUE ESTAN UNIDOS FORMAN UN ANILLO DE 5 O 6 MIEMBROS SUSTITUIDO O NO SUSTITUIDO QUE CONTIENEN 0 A 2 HETEROATOMOS SELECCIONADOS ENTRE O, S, SO, SO2, NRx DONDE Rx ES H, ALQUILO (C1-C6). SON COMPUESTOS PREFERIDOS:ACIDO 7- [3- (2-CIANO-ETILAMINO)-PIRROLIDIN-1-IL]-1-CICLOPROPIL-6-FLUORO-8-METOXI-4- OXO-1, 4-DIHIDRO-QUINOLIN-3-CARBOXILICO; ACIDO 7- [3- (2-CIANO-ETILAMINO)-PIRROLIDIN-1-IL]-1-CICLOPROPIL-6-FLUORO-8-METIL-4-OXO-1, 4-DIHIDRO-QUINOLIN-3-CARBOXILICO; ACIDO 7- {3-[(2-CIANO-ETIL)-METIL-AMINO]-PIRROLIDIN-1-IL}-1-CICLOPROPIL-6-FLUORO-8- METOXI-4-OXO-1, 4-DIHIDRO-QUINOLIN-3-CARBOXILICO; ACIDO 7-{3-[(2-CIANO-ETIL)-METIL-AMINO]-PIRROLIDIN-L-IL}-1-CICLOPROPIL-6-FLUORO-8- METIL-4-OXO-1,4-DIHIDRO-QUINOLIN-3-CARBOXILICO , ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA UTIL PARA EL TRATAMIENTO DE UNA INFECCION BACTERIANAREFERS TO QUINOLONE DERIVATIVES OF FORMULA I WHERE X IS N, C WITH THE CONDITION THAT WHEN X IS N, R5 IS ABSENT IN THAT POSITION; R1 IS ALKYL (C1-C6), HALO-ALKYL (C1-C6), CYCLOALKYL (C1-C6), HALO-CYCLOALKYL (C3-C6), HETEROCYCLYL, ARYL, HETEROARYL, AMONG OTHERS; R2 IS OH, OBF2, O-ALKYL (C1-C6), O-CYCLOALKYL (C3-C6), AMONG OTHERS; R3, R4 AND R5 ARE H, OH, HALO, NRyRz WHERE EACH OF Ry AND Rz IS INDEPENDENTLY H OR ALKYL (C1-C6); R1 AND R5 TAKEN TOGETHER WITH THE CARBONS TO WHICH THEY ARE UNITED FORM A SUBSTITUTED OR NON-SUBSTITUTED RING OF 5 OR 6 MEMBERS CONTAINING 0 TO 2 HETEROATOMS SELECTED FROM O, S, SO, SO2, NRx WHERE Rx IS H, RENT (C1 -C6). PREFERRED COMPOUNDS ARE: ACID 7- [3- (2-CYANE-ETHYLAMINE) -PYRROLIDIN-1-IL] -1-CYCLOPROPYL-6-FLUORO-8-METOXY-4-OXO-1, 4-DIHYDRO-QUINOLIN-3 -CARBOXYL; 7- [3- (2-CYANE-ETHYLAMINE) -PYRROLIDIN-1-IL] -1-CYCLOPROPYL-6-FLUORO-8-METHYL-4-OXO-1,4-DIHYDRO-QUINOLIN-3-CARBOXYL ACID; ACID 7- {3 - [(2-CYANE-ETHYL) -METHYL-AMINO] -PYRROLIDIN-1-IL} -1-CYCLOPROPYL-6-FLUORO-8-METOXY-4-OXO-1, 4-DIHYDRO-QUINOLIN -3-CARBOXYL; ACID 7- {3 - [(2-CYANE-ETHYL) -METHYL-AMINO] -PYRROLIDIN-L-IL} -1-CYCLOPROPYL-6-FLUORO-8-METHYL-4-OXO-1,4-DIHYDRO-QUINOLINE -3-CARBOXYL, AMONG OTHERS. ALSO REFERS TO A USEFUL PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF A BACTERIAL INFECTION

PE2004001119A 2003-11-18 2004-11-16 QUINOLONE DERIVATIVES AS ANTIBACTERIAL AGENTS PE20050582A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52307103P 2003-11-18 2003-11-18
US60549604P 2004-08-31 2004-08-31

Publications (1)

Publication Number Publication Date
PE20050582A1 true PE20050582A1 (en) 2005-08-25

Family

ID=34623167

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2004001119A PE20050582A1 (en) 2003-11-18 2004-11-16 QUINOLONE DERIVATIVES AS ANTIBACTERIAL AGENTS

Country Status (6)

Country Link
AR (1) AR046638A1 (en)
NL (1) NL1027545C2 (en)
PE (1) PE20050582A1 (en)
TW (1) TW200524930A (en)
UY (1) UY28622A1 (en)
WO (1) WO2005049602A1 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101077755B1 (en) 2003-09-10 2011-10-27 교린 세이야꾸 가부시키 가이샤 7-(4-substituted 3-cyclopropylaminomethyl-1 pyrrolidinyl)quinolonecarboxylic acid derivative
ES2396913T3 (en) 2005-08-04 2013-03-01 Sirtris Pharmaceuticals, Inc. Sirtuin modulating compounds
DE102006005861A1 (en) * 2006-02-09 2007-08-23 Aicuris Gmbh & Co. Kg Substituted quinolones III
CN101622240B (en) * 2007-01-05 2014-07-23 第一三共株式会社 Fused substituted aminopyrrolidine derivative
EP2097400B1 (en) * 2007-01-05 2013-07-03 Daiichi Sankyo Company, Limited Fused substituted aminopyrrolidine derivative
EP2149571A4 (en) 2007-05-24 2010-09-01 Kyorin Seiyaku Kk Mutilin derivative having heterocyclic aromatic ring carboxylic acid structure in substituent at 14-position
DE102007036068A1 (en) 2007-08-01 2009-02-05 Wacker Chemie Ag Process for the preparation of alkylmethoxymethyltrimethylsilanylmethylamines
BRPI0913291A2 (en) 2008-05-30 2019-01-15 Takeda Pharmaceuticals Co compound, prodrug, drug, methods for decreasing protein 4 or treating diabetes in a mammal, and use of the compound
BRPI1008661B8 (en) 2009-02-06 2021-05-25 Nippon Shinyaku Co Ltd aminopyrazine-derived compounds, their use and pharmaceutical composition
AR091858A1 (en) 2012-07-25 2015-03-04 Sova Pharmaceuticals Inc CISTATIONIN-g-LIASA INHIBITORS (CSE)
JP6908536B2 (en) 2015-06-09 2021-07-28 バイエル・ファルマ・アクティエンゲゼルシャフト Positive allosteric modulator of muscarinic M2 receptor
JP2019524722A (en) 2016-07-11 2019-09-05 バイエル・ファルマ・アクティエンゲゼルシャフト 7-substituted 1-pyridyl-naphthyridine-3-carboxylic acid amides and uses thereof
EP3296298A1 (en) 2016-09-14 2018-03-21 Bayer Pharma Aktiengesellschaft 7-substituted 1-aryl-naphthyridin-3-carboxamides and their use
JOP20190045A1 (en) 2016-09-14 2019-03-14 Bayer Ag 7-substituted 1-aryl-naphthyridine-3-carboxylic acid amides and use thereof
BR112019006448A2 (en) 2016-09-29 2019-06-25 Bayer Cropscience Ag new substituted 5-imidazole derivatives

Also Published As

Publication number Publication date
NL1027545A1 (en) 2005-05-23
NL1027545C2 (en) 2006-01-17
WO2005049602A1 (en) 2005-06-02
TW200524930A (en) 2005-08-01
AR046638A1 (en) 2005-12-14
UY28622A1 (en) 2005-06-30

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