PE20040697A1 - Composicion farmaceutica que comprende un antagonista de ltb4 y un inhibidor de la cox-2 o cox-1/2 combinado - Google Patents

Composicion farmaceutica que comprende un antagonista de ltb4 y un inhibidor de la cox-2 o cox-1/2 combinado

Info

Publication number
PE20040697A1
PE20040697A1 PE2003001187A PE2003001187A PE20040697A1 PE 20040697 A1 PE20040697 A1 PE 20040697A1 PE 2003001187 A PE2003001187 A PE 2003001187A PE 2003001187 A PE2003001187 A PE 2003001187A PE 20040697 A1 PE20040697 A1 PE 20040697A1
Authority
PE
Peru
Prior art keywords
cox
inhibitor
pharmaceutically acceptable
combined
pharmaceutical composition
Prior art date
Application number
PE2003001187A
Other languages
English (en)
Inventor
Franz Birke
Hans Michael Jennewein
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of PE20040697A1 publication Critical patent/PE20040697A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Neurosurgery (AREA)
  • Communicable Diseases (AREA)
  • Vascular Medicine (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE COMPRENDE: 1) UN AGENTE ANTAGONISTA DEL RECEPTOR DE LEUCOTRIENO B4 (LTB4), QUE TIENE UN GRUPO HIDROXI Y UN BENZAMIDINO, PREFERENTEMENTE DE FORMULA (I) EN LA QUE R ES H, CO2-R`, EN DONDE R` ES ALQUILO(C1-C6), FENILO O BENCILO OPCIONALMENTE SUSTITUIDOS POR HALOGENO, ALQUILO(C1-C6), ALCOXI(C1-C6), CN, NITRO, HALOALQUILO(C1-C6) Y HALOALCOXI(C1-C6); A SON A1 O A2. SIENDO UN COMPUESTO PREFERIDO EL ESTER ETILICO DEL ACIDO [[4-[[3-[[4-[1-(4-HIDROXIFENIL)-1-METILETIL]FENOXI]METIL]FENIL]-METOXI]FENIL]IMINOMETIL]-CARBAMICO, CON 2) POR LO MENOS UN AGENTE INHIBIDOR DE CICLOOXIGENASA-2 O UN INHIBIDOR DE COX1/COX2 SELECCIONADO ENTRE EL GRUPO QUE CONSTA DE CELECOXIB, DUPONT DUP 697, ETODOLAC, ETORICOXIB, FLOSULIDE, MELOXICAM, NIMESULIDE, PARECOXIB, ROFECOXIB, VALDECOXIB Y EN PARTICULAR MELOXICAM Y 3) Y UN VEHICULO O EXCIPIENTE Y OPCIONALMENTE UNO O MAS AGENTES TERAPEUTICOS. ESTA FORMULACION PUEDE SER ADMINISTRADA POR VIA ORAL, INTRAVASCULAR, INTRAPERITONEAL, SUBCUTANEA, INTRAMUSCULAR O TOPICA, EN DONDE LA RELACION EN PESO DE ANTAGONISTA DE LTB4:INHIBIDOR DE CICLOOXIGENASA-2 O INHIBIDOR DE COX1/COX2 ES ENTRE 50:1 Y 1:300. TAMBIEN SE REFIERE A UN METODO DE TRATAMIENTO EN FORMA COMBINADA, SEPARADA O BIEN POR SEPARADO Y CONSECUTIVAMENTE. ESTA FORMULACION ES UTIL PARA LA PREVENCION O TRATAMIENTO DE ARTRITIS REUMATOIDE, DERMATITIS ATOPICA Y ENFERMEDAD CARDIACA CORONARIA
PE2003001187A 2002-11-26 2003-11-24 Composicion farmaceutica que comprende un antagonista de ltb4 y un inhibidor de la cox-2 o cox-1/2 combinado PE20040697A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP02026223 2002-11-26

Publications (1)

Publication Number Publication Date
PE20040697A1 true PE20040697A1 (es) 2004-11-22

Family

ID=32337995

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2003001187A PE20040697A1 (es) 2002-11-26 2003-11-24 Composicion farmaceutica que comprende un antagonista de ltb4 y un inhibidor de la cox-2 o cox-1/2 combinado

Country Status (23)

Country Link
US (1) US20040116516A1 (es)
EP (1) EP1572179B1 (es)
JP (1) JP2006508992A (es)
KR (1) KR20050086820A (es)
CN (1) CN1717228A (es)
AT (1) ATE355055T1 (es)
AU (1) AU2003298121A1 (es)
BR (1) BR0316486A (es)
CA (1) CA2506948A1 (es)
CO (1) CO5580753A2 (es)
DE (1) DE60312215T2 (es)
EA (1) EA200500860A1 (es)
EC (1) ECSP055804A (es)
ES (1) ES2282727T3 (es)
HR (1) HRP20050466A2 (es)
MX (1) MXPA05005393A (es)
PE (1) PE20040697A1 (es)
PL (1) PL375503A1 (es)
RS (1) RS20050390A (es)
TW (1) TW200500330A (es)
UY (1) UY28095A1 (es)
WO (1) WO2004047824A1 (es)
ZA (1) ZA200502410B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA200971133A1 (ru) * 2004-06-29 2010-10-29 Никомед Данмарк Апс Производство фармацевтических композиций с быстрым высвобождением на основе водонерастворимых лекарственных средств и фармацевтические композиции, получаемые способом по изобретению
CN110869362A (zh) 2017-05-12 2020-03-06 国立研究开发法人理化学研究所 A类gpcr结合性化合物改性体

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4424713A1 (de) * 1994-07-13 1996-01-18 Boehringer Ingelheim Kg Substituierte Benzamidine, ihre Herstellung und Verwendung als Arnzneistoffe
US6342510B1 (en) * 1995-06-12 2002-01-29 G. D. Searle & Co. Treatment of inflammation and inflammation-related disorders with a combination of a cyclooxygenase-2 inhibitors and a leukotriene B4 receptor antagonist
DE19546452A1 (de) * 1995-12-13 1997-06-19 Boehringer Ingelheim Kg Neue Phenylamidinderivate, Verfahren zu ihrer Herstelung und ihre Verwendung als Arzneimittel
ATE296114T1 (de) * 1996-02-13 2005-06-15 Searle & Co Zubereitungen, enthaltend einen cyclooxygenase-2- inhibitor und einen leukotrien-b4-rezeptor- antagonisten
DE19636689A1 (de) * 1996-09-10 1998-03-12 Boehringer Ingelheim Kg Neue Benzamidinderivate
US6197753B1 (en) * 1997-09-10 2001-03-06 Boehringer Ingelheim Kg Pyranoside derivatives
US6291531B1 (en) * 1999-10-07 2001-09-18 Boehringer Ingelheim Pharma Kg LTB4 antagonist, processes for the preparation thereof and its use as a pharmaceutical composition
US6417382B2 (en) * 2000-01-12 2002-07-09 Boehringer Ingelheim Pharma Kg Process for preparing aryl-iminomethyl-carbamino acid esters
PE20020322A1 (es) * 2000-08-18 2002-05-10 Pharmacia Corp Formulacion oral de rapida disolucion de un inhibidor de la ciclooxigenasa 2
CA2433451A1 (en) * 2001-01-16 2002-07-18 Boehringer Ingelheim Pharma Gmbh & Co. Kg Use of an ltb4 antagonist for the treatment and/or prevention of diseases caused by increased expression of mucin genes
HUP0401371A3 (en) * 2001-07-14 2010-01-28 Boehringer Ingelheim Pharma Pharmaceutical formulation containing an ltb4 antagonist and process for its preparation
US20030119901A1 (en) * 2001-07-14 2003-06-26 Boehringer Ingelheim Pharma Kg Pharmaceutical formulation containing an LTB4 antagonist

Also Published As

Publication number Publication date
DE60312215T2 (de) 2007-06-28
TW200500330A (en) 2005-01-01
CO5580753A2 (es) 2005-11-30
US20040116516A1 (en) 2004-06-17
DE60312215D1 (de) 2007-04-12
ECSP055804A (es) 2005-08-11
EP1572179B1 (en) 2007-02-28
UY28095A1 (es) 2004-06-30
RS20050390A (en) 2008-04-04
CA2506948A1 (en) 2004-06-10
ZA200502410B (en) 2005-10-03
ATE355055T1 (de) 2006-03-15
BR0316486A (pt) 2005-10-11
PL375503A1 (en) 2005-11-28
WO2004047824A1 (en) 2004-06-10
KR20050086820A (ko) 2005-08-30
AU2003298121A1 (en) 2004-06-18
EP1572179A1 (en) 2005-09-14
JP2006508992A (ja) 2006-03-16
ES2282727T3 (es) 2007-10-16
EA200500860A1 (ru) 2005-12-29
HRP20050466A2 (en) 2006-07-31
MXPA05005393A (es) 2005-08-03
CN1717228A (zh) 2006-01-04

Similar Documents

Publication Publication Date Title
NO20042596L (no) Inbibitorer av 11-beta-hydroksy steroid dehydrogenase type 1
MXPA04004842A (es) Inhibidores de 11-(-hidroxiesteroide deshidrogenasa de tipo 1.
SE0001899D0 (sv) New compounds
BR0311931A (pt) Composto, composição farmacêutica, uso de um composto, e, método para tratar uma doença ou condição mediada com hppar em um paciente
ECSP056194A (es) Derivados de pirazolo-quinazolina, procedimiento para su preparacion y su uso como inhibidores de quinasa
TR200103186T2 (tr) MEK enzimlerinin inhibitörleri olarak kinolin türevleri
NO20062019L (no) P-glykoproteininhibitor, fremgangsmater for fremstilling av denne samt farmasoytiske preparater inneholdende den samme
SG147450A1 (en) Sustained release pharmaceutical compositions comprising aplindore and derivatives thereof
CY1107819T1 (el) Φαρμακευτικη διαμορφωση της ολανζαπινης
UA86776C2 (ru) Производные бензимидазола, фармацевтическая композиция, которая их содержит, способ их получения и применение
SE0300908D0 (sv) Azaindole derivatives, preparations thereof, uses thereof and compositions containing them
RS44204A (en) Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
UA83832C2 (ru) Производные бензимидазола, фармацевтическая композиция, которая их содержит, способ их получения и их применение
SE0302570D0 (sv) Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
SE0302572D0 (sv) Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
RS44304A (en) Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
CO5580753A2 (es) Composicion farmaceutica que comprende un antagonista ltb4 y un inhibidor cox-2 o un inhibidor cox1/2
BRPI0412453A (pt) uso do ácido ascórbico ou um sal fisiologicamente aceitável do mesmo
HUP0301334A2 (hu) Szubsztituált akriloil-disztamicin-származékokat és taxánokat és/vagy antimetabolitokat tartalmazó kombinált tumorellenes kompozíciók
WO2004108094A3 (en) Sulfonamide-substituted chalcone derivatives and their use to treat diseases
NO20053087L (no) Farmasoytisk sammensetning omfattende en LTB4 antagonist og en COX-2 inhibitor eller en kombinert COX 1/2 inhibitor.
SE0301698D0 (sv) Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
SE0402640D0 (sv) Pharmaceutical use
EP1710235A4 (en) EXTRACTS OF MARASMINS ANDROSACEUS L.ES, PIPERDINONE DERIVATIVES AND THEIR USE AS BLOOD PRESSURE MEDICINES
UA87327C2 (ru) Производные бензимидазола, композиция, которая их содержит, их получение и применение

Legal Events

Date Code Title Description
FC Refusal