PE20030364A1 - Sistemas de indan-1-ol varias veces sustituidos y procedimiento para su preparacion - Google Patents

Sistemas de indan-1-ol varias veces sustituidos y procedimiento para su preparacion

Info

Publication number
PE20030364A1
PE20030364A1 PE2002000818A PE2002000818A PE20030364A1 PE 20030364 A1 PE20030364 A1 PE 20030364A1 PE 2002000818 A PE2002000818 A PE 2002000818A PE 2002000818 A PE2002000818 A PE 2002000818A PE 20030364 A1 PE20030364 A1 PE 20030364A1
Authority
PE
Peru
Prior art keywords
indan
preparation
procedure
systems
several times
Prior art date
Application number
PE2002000818A
Other languages
English (en)
Inventor
Martin Bickel
Volker Krone
Gerhard Jaehne
Matthias Gossel
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of PE20030364A1 publication Critical patent/PE20030364A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C323/17—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C317/20—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of rings other than six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

SE REFIERE INDAN-1-OL VARIAS VECES DE FORMULA I DONDE R1-R4 SON H, F, Cl, Br, I, CN, N3, NO2, OH, OALQUILO (C1-C8), OCICLOALQUILO(C3-C8), O-CH2-FENILO, ENTRE OTROS; R2 Y R3 JUNTOS FORMAN EL RADICAL -O-CH2-O-; X ES S, SO, SO2; Y ES (CH2)p DONDE p PUEDE SER 0-3; R5 ALQUILO C1-C18, CICLOALQUILO C3-C4, CICLOALQUILO C6-C8, DONDE LOS GRUPOS ALQUILO PUEDEN ESTAR REEMPLAZADOS CON F, (CH2)1-6-COOH, ENTRE OTROS; R6 ES (CH2)0-6-R9, (CH2)0-6-COOH, (CH2)0-6-CONH2, ENTRE OTROS; R7 ES (CH2)0-4-R12, H,LQUILO C1-C12, CICLOALQUILO C3-C4, CICLOALQUILO C3-C8, COOALQUILO C1-C6, ENTRE OTROS; R8 ES (CH2)0-4-R14, ALQUILO C1-C12, CICLOALQUILO C3-C4, CICLOALQUILO C6-C8, ENTRE OTROS; R9, R12 Y R14 SON FENILO, 1-, 2-NAFTILO, BIFENILO, UN RADICAL HETEROCICLICO, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO PARA LA PREPARACION. SON COMPUESTOS PREFERIDOS 5-CLORO-2-FLUORO-2-METANSULFANIL-INDAN-1-OL, 5-CLORO-2-FLUORO-2-METANOSULFONIL-1-TRIFLUOROMETIL-INDAN-1-OL. LOS COMPUESTOS MENCIONADOS SON UTILES COMO ANOREXICOS
PE2002000818A 2001-08-31 2002-08-26 Sistemas de indan-1-ol varias veces sustituidos y procedimiento para su preparacion PE20030364A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10142661A DE10142661B4 (de) 2001-08-31 2001-08-31 Mehrfach substituierte Indan-1-ol-Systeme und ihre Verwendung als Arzneimittel

Publications (1)

Publication Number Publication Date
PE20030364A1 true PE20030364A1 (es) 2003-06-04

Family

ID=7697232

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2002000818A PE20030364A1 (es) 2001-08-31 2002-08-26 Sistemas de indan-1-ol varias veces sustituidos y procedimiento para su preparacion

Country Status (11)

Country Link
US (3) US6670401B2 (es)
EP (1) EP1423358B1 (es)
JP (1) JP4250077B2 (es)
AT (1) ATE476413T1 (es)
AU (1) AU2002329252B2 (es)
CA (1) CA2458520C (es)
DE (2) DE10142661B4 (es)
IL (1) IL160602A0 (es)
MX (1) MXPA04001854A (es)
PE (1) PE20030364A1 (es)
WO (1) WO2003020693A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10142659A1 (de) * 2001-08-31 2003-03-20 Aventis Pharma Gmbh Verwendung von mehrfach substituierten Indan-1-ol. Systemen zur Herstellung von Medikamenten zur Prophylaxe oder Behandlung von Obesitas
DE10142663B4 (de) 2001-08-31 2004-08-19 Aventis Pharma Deutschland Gmbh C2-Disubstituierte Indan-1-ol-Systeme

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2201882B1 (es) * 1972-07-20 1975-10-31 Logeais Labor Jacques
GB1465794A (en) * 1974-05-17 1977-03-02 Wyeth John & Brother Ltd Thiourea derivatives
DE2640358A1 (de) * 1976-09-08 1978-03-16 Hoechst Ag Thiazolidinderivate und verfahren zu ihrer herstellung
DE2965279D1 (en) * 1978-07-27 1983-06-01 Schering Ag Indanyl derivatives, process for their preparation and pharmaceutical compositions containing these compounds
DE3103372A1 (de) * 1981-01-27 1982-09-02 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue indanyl-derivate, ihre herstellung und verwendung
GB2323088A (en) * 1995-12-06 1998-09-16 Venantius Limited Indane dimer compounds and their pharmaceutical use
BR9707003A (pt) 1996-01-17 1999-07-20 Novo Nordisk As Composto processos para preparar o mesmo para tratamento ou de prevenção de doenças do sistema endócrino e para a manufatura de medicamento coposção farmacêutica e utilização de um composto
CA2468374C (en) 1996-08-30 2010-12-21 Novo-Nordisk A/S Glp-1 derivatives
CN1190434C (zh) 1996-12-31 2005-02-23 雷迪实验室有限公司 新的杂环化合物、其制备方法和含有它们的药物组合物及其在治疗糖尿病和相关疾病中的应用
BR9810592A (pt) 1997-07-16 2000-09-12 Novo Nordisk As Composto, processos para preparar um composto, para tratar ou prevenir doenças do sistema endócrino e para a fabricação de um medicamento, composição farmacêutica, e, uso de um composto
FR2769312B1 (fr) * 1997-10-03 1999-12-03 Adir Nouveaux composes de l'indanol, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2782515B1 (fr) * 1998-08-21 2000-09-22 Adir NOUVEAUX DERIVES DE L'INDANE-1-Ol, LEUR PROCEDE DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT
EP1078632A1 (en) 1999-08-16 2001-02-28 Sanofi-Synthelabo Use of monoamine oxydase inhibitors for the manufacture of drugs intended for the treatment of obesity
DE10142662B4 (de) * 2001-08-31 2004-07-08 Aventis Pharma Deutschland Gmbh Derivate von C2-substituierten Indan-1-ol-Systemen und ihre Verwendung als Arzneimittel
DE10142659A1 (de) * 2001-08-31 2003-03-20 Aventis Pharma Gmbh Verwendung von mehrfach substituierten Indan-1-ol. Systemen zur Herstellung von Medikamenten zur Prophylaxe oder Behandlung von Obesitas

Also Published As

Publication number Publication date
IL160602A0 (en) 2004-07-25
US20030105145A1 (en) 2003-06-05
DE10142661B4 (de) 2004-06-09
MXPA04001854A (es) 2004-06-15
US20040092489A1 (en) 2004-05-13
EP1423358B1 (de) 2010-08-04
CA2458520A1 (en) 2003-03-13
EP1423358A1 (de) 2004-06-02
WO2003020693A1 (de) 2003-03-13
US20040092749A1 (en) 2004-05-13
DE10142661A1 (de) 2003-03-27
CA2458520C (en) 2010-12-14
AU2002329252B2 (en) 2007-08-23
JP4250077B2 (ja) 2009-04-08
DE50214570D1 (de) 2010-09-16
ATE476413T1 (de) 2010-08-15
JP2005501901A (ja) 2005-01-20
US6670401B2 (en) 2003-12-30

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