PE20010204A1 - Hidroxiamidas de acidos 3-(arilsulfonilamino)-tetrahidrofuran-3-carboxilicos como inhibidores de metaloproteasas y reprolisina - Google Patents
Hidroxiamidas de acidos 3-(arilsulfonilamino)-tetrahidrofuran-3-carboxilicos como inhibidores de metaloproteasas y reprolisinaInfo
- Publication number
- PE20010204A1 PE20010204A1 PE2000000510A PE0005102000A PE20010204A1 PE 20010204 A1 PE20010204 A1 PE 20010204A1 PE 2000000510 A PE2000000510 A PE 2000000510A PE 0005102000 A PE0005102000 A PE 0005102000A PE 20010204 A1 PE20010204 A1 PE 20010204A1
- Authority
- PE
- Peru
- Prior art keywords
- cancer
- metaloproteases
- arylsulfonylamine
- reprolysin
- hydroxyamides
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
SE REFIERE A DERIVADOS HIDROXIAMIDA DE ACIDOS 3-(ARILSULFONILAMINO)-TETRAHIDROFURAN-3-CARBOXILICOS, DONDE: R1 ES H, OH, ALQUILO C1-6, ALCOXI C1-C6, (ALCOXI C1-C6)(ALCOXI C1-C6, ENTRE OTROS; R2 ES H, OH, ALQUILO C1-C6, ALCOXI C1-C6, ALCOXI C1-C6-ALCOXI C1-C6, ENTRE OTROS; CON LA CONDICION QUE CUANDO UNO DE R1 O R2 ES OH, EL OTRO NO ES OH, ALCOXI C1-C6, ALCOXI C1-C6-ALCOXI C1-C6, ENTRE OTROS; O R1 JUNTO CON R2 FORMAN UN CARBONILO; Q ES ALQUILO C1-C6, ARILO C6-C10, HETEROARILO C2-C9, (ARILOXI C6-C10)(ALQUILO C1-C6), ENTRE OTROS. SON COMPUESTOS PREFERIDOS HIDROXIAMIDA DEL ACIDO 3-[4-(4-FLUOROFENOXI)BENCENO-SULFONILAMINO]TETRAHIDROFURAN-3-CARBOXILICO, HIDROXIAMIDA DEL ACIDO 3-[4-(4-CLOROFENOXI)BENCENOSULNILAMMINO]TETRAHIDROFURAN-3-CARBOXILICO. EL COMPUESTO I ES UN INHIBIDOR DE LA REPROLISINA Y PUEDE SER UTIL PARA EL TRATAMIENTO DE LA ARTRITIS, ENFERMEDAD INFLAMATORIA DEL INTESTINO, ENFERMEDAD DE CROHN, ENFISEMA, ENFERMEDAD PULMONAR OBSTRUCTIVA CRONICA
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13667799P | 1999-05-28 | 1999-05-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20010204A1 true PE20010204A1 (es) | 2001-03-05 |
Family
ID=22473882
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2000000510A PE20010204A1 (es) | 1999-05-28 | 2000-05-26 | Hidroxiamidas de acidos 3-(arilsulfonilamino)-tetrahidrofuran-3-carboxilicos como inhibidores de metaloproteasas y reprolisina |
Country Status (19)
Country | Link |
---|---|
US (1) | US6342521B1 (es) |
EP (1) | EP1181285B1 (es) |
JP (1) | JP3828748B2 (es) |
AT (1) | ATE251618T1 (es) |
AU (1) | AU4309800A (es) |
BR (1) | BR0011538A (es) |
CA (1) | CA2375513C (es) |
DE (1) | DE60005818T2 (es) |
DK (1) | DK1181285T3 (es) |
ES (1) | ES2203456T3 (es) |
GT (1) | GT200000084A (es) |
HN (1) | HN2000000052A (es) |
MA (1) | MA26737A1 (es) |
MX (1) | MXPA01012266A (es) |
PE (1) | PE20010204A1 (es) |
PT (1) | PT1181285E (es) |
TN (1) | TNSN00114A1 (es) |
UY (1) | UY26169A1 (es) |
WO (1) | WO2000073294A2 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6833373B1 (en) | 1998-12-23 | 2004-12-21 | G.D. Searle & Co. | Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia |
JP4343373B2 (ja) * | 2000-01-14 | 2009-10-14 | 富士フイルム株式会社 | 写真サービスシステム及びデジタルカメラ |
KR20020081465A (ko) | 2000-03-21 | 2002-10-26 | 더 프록터 앤드 갬블 캄파니 | 헤테로시클릭 측쇄 함유, n-치환된 메탈로프로테아제저해제 |
IL151250A0 (en) | 2000-03-21 | 2003-04-10 | Procter & Gamble | Difluorobutyric acid metalloprotease inhibitors |
WO2001070690A1 (en) * | 2000-03-21 | 2001-09-27 | The Procter & Gamble Company | Heterocyclic side chain containing metalloprotease inhibitors |
US6548539B1 (en) * | 2001-03-05 | 2003-04-15 | Avalon Pharmaceuticals | Agents for regulation of colon cancer gene expression |
GB0319069D0 (en) * | 2003-08-14 | 2003-09-17 | Glaxo Group Ltd | Therapeutically useful compounds |
DK2385938T3 (en) | 2009-01-12 | 2015-04-27 | Pfizer Ltd | Sulfonamidderivater |
EP2590972B1 (en) | 2010-07-09 | 2015-01-21 | Pfizer Limited | N-sulfonylbenzamides as inhibitors of voltage-gated sodium channels |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5455258A (en) * | 1993-01-06 | 1995-10-03 | Ciba-Geigy Corporation | Arylsulfonamido-substituted hydroxamic acids |
US5663357A (en) * | 1995-11-22 | 1997-09-02 | Allergan | Substituted heteroarylamides having retinoid-like biological activity |
PL334846A1 (en) * | 1997-01-23 | 2000-03-27 | Hoffmann La Roche | Sulphamidic inhibitors of metaloproteases |
PT977733E (pt) * | 1997-02-03 | 2003-12-31 | Pfizer Prod Inc | Derivados de acido arilsulfonilamino-hidroxamico |
EP0925289A1 (en) * | 1997-07-10 | 1999-06-30 | PHARMACIA & UPJOHN S.p.A. | Matrix metalloproteinase inhibitors |
JP2001513484A (ja) * | 1997-07-31 | 2001-09-04 | ザ プロクター アンド ギャンブル カンパニー | 非環式メタロプロテアーゼ阻害剤 |
-
2000
- 2000-04-12 HN HN2000000052A patent/HN2000000052A/es unknown
- 2000-05-15 WO PCT/IB2000/000646 patent/WO2000073294A2/en active IP Right Grant
- 2000-05-15 DK DK00922821T patent/DK1181285T3/da active
- 2000-05-15 EP EP00922821A patent/EP1181285B1/en not_active Expired - Lifetime
- 2000-05-15 MX MXPA01012266A patent/MXPA01012266A/es active IP Right Grant
- 2000-05-15 CA CA002375513A patent/CA2375513C/en not_active Expired - Fee Related
- 2000-05-15 DE DE60005818T patent/DE60005818T2/de not_active Expired - Fee Related
- 2000-05-15 PT PT00922821T patent/PT1181285E/pt unknown
- 2000-05-15 ES ES00922821T patent/ES2203456T3/es not_active Expired - Lifetime
- 2000-05-15 AU AU43098/00A patent/AU4309800A/en not_active Abandoned
- 2000-05-15 BR BR0011538-0A patent/BR0011538A/pt not_active IP Right Cessation
- 2000-05-15 JP JP2000621360A patent/JP3828748B2/ja not_active Expired - Fee Related
- 2000-05-15 AT AT00922821T patent/ATE251618T1/de not_active IP Right Cessation
- 2000-05-24 TN TNTNSN00114A patent/TNSN00114A1/fr unknown
- 2000-05-24 MA MA25987A patent/MA26737A1/fr unknown
- 2000-05-25 US US09/578,661 patent/US6342521B1/en not_active Expired - Fee Related
- 2000-05-26 UY UY26169A patent/UY26169A1/es not_active Application Discontinuation
- 2000-05-26 PE PE2000000510A patent/PE20010204A1/es not_active Application Discontinuation
- 2000-05-26 GT GT200000084A patent/GT200000084A/es unknown
Also Published As
Publication number | Publication date |
---|---|
JP2003500484A (ja) | 2003-01-07 |
AU4309800A (en) | 2000-12-18 |
DE60005818D1 (de) | 2003-11-13 |
WO2000073294A3 (en) | 2001-03-29 |
MA26737A1 (fr) | 2004-12-20 |
UY26169A1 (es) | 2000-12-29 |
ATE251618T1 (de) | 2003-10-15 |
BR0011538A (pt) | 2002-02-26 |
CA2375513C (en) | 2006-11-28 |
HN2000000052A (es) | 2001-02-02 |
DK1181285T3 (da) | 2004-01-26 |
WO2000073294A2 (en) | 2000-12-07 |
MXPA01012266A (es) | 2002-07-30 |
GT200000084A (es) | 2001-11-17 |
PT1181285E (pt) | 2004-01-30 |
JP3828748B2 (ja) | 2006-10-04 |
EP1181285A2 (en) | 2002-02-27 |
EP1181285B1 (en) | 2003-10-08 |
US6342521B1 (en) | 2002-01-29 |
ES2203456T3 (es) | 2004-04-16 |
TNSN00114A1 (fr) | 2002-05-30 |
DE60005818T2 (de) | 2004-05-06 |
CA2375513A1 (en) | 2000-12-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD | Application declared void or lapsed |