PE20001598A1 - DERIVATIVES OF N- [2- (4-AMINOPHENIL) ETHYL] -2,3-DIHYDRO-1,4-BENZODIOXIN-2-METANAMINA - Google Patents

DERIVATIVES OF N- [2- (4-AMINOPHENIL) ETHYL] -2,3-DIHYDRO-1,4-BENZODIOXIN-2-METANAMINA

Info

Publication number
PE20001598A1
PE20001598A1 PE2000000275A PE0002752000A PE20001598A1 PE 20001598 A1 PE20001598 A1 PE 20001598A1 PE 2000000275 A PE2000000275 A PE 2000000275A PE 0002752000 A PE0002752000 A PE 0002752000A PE 20001598 A1 PE20001598 A1 PE 20001598A1
Authority
PE
Peru
Prior art keywords
benzodioxin
dihydro
derivatives
ethyl
alcoxycarbonylmethyl
Prior art date
Application number
PE2000000275A
Other languages
Spanish (es)
Inventor
Yannick Evanno
Peretti Daniele De
Jean Francois Gibert
Michel Peynot
Maria Carmen Renones
Jocelyne Roy
Garcia Antonio Almario
Original Assignee
Sanofi Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo filed Critical Sanofi Synthelabo
Publication of PE20001598A1 publication Critical patent/PE20001598A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIERE A DERIVADOS DE N-[2-(4-AMINOFENIL)ETIL]-2,3-DIHIDRO-1,4-BENZODIOXIN-2-METANAMINA DE FORMULA I, DONDE: X ES H, HALOGENO, CIANO, NITRO, OH, ALQUILO C1-C4, FENILO, TIENILO, TIENILMETOXI, ALCOXI C1-C4, CICLOALQUILMETOXI C3-C6, FENILMETOXI, ALCOXICARBONILO C1-C4, ALCOXICARBONILMETILO C1-C4, PIRROLIDIN-1-ILCARBONILO, CARBAMOILO, ENTRE OTROS; R1 ES H, METILO; R2 ES ALCANOILO C1-C4, FENILALCANOILO C1-C4, METOXIACETILO, CICLOALQUILCARBONILO C3-C6, BENZOILO OPCIONALMENTE SUSTITUIDO CON HALOGENO, ALQUILO C1-C4, ALCOXI C1-C4, ENTRE OTROS; NR1R2 ES 2-OXO-4,5-DIHIDROOXAZOLIDIN-3-ILO. LOS COMPUESTOS DE FORMULA I TIENEN AFINIDAD POR LOS RECEPTORES DOPAMINERGICOS DE TIPO D3, AFINIDAD MODERADA DE TIPO D2 Y 5-HT1A Y PUEDEN SER UTILES PARA EL TRATAMIENTO DE PSICOSIS, ESQUIZOFRENIA, ANSIEDAD, PANICO, FOBIAS, TRASTORNOS OBSESIVO COMPULSIVOSREFERS TO DERIVATIVES OF N- [2- (4-AMINOPHENYL) ETHYL] -2,3-DIHYDRO-1,4-BENZODIOXIN-2-METHANAMINE OF FORMULA I, WHERE: X IS H, HALOGEN, CYANE, NITRO, OH , C1-C4 ALKYL, PHENYL, THENYL, THYENYLMETOXY, C1-C4 ALCOXY, C3-C6 CYCLOALKYLMETOXY, PHENYLMETOXY, C1-C4 ALCOXYCARBONYL, 1-CARBONYL ALCOXYCARBONYLMETHYL-ILCHRONYL, C1-C4 CARBONYL-1-PYRAMYL-ILCOXYCARBONYL, C1-C4, ALCOXYCARBONYLMETHYL-ILCHYL-C4 R1 IS H, METHYL; R2 IS C1-C4 ALKANOYL, C1-C4 PHENYLALKANOYL, METOXYACETYL, C3-C6 CYCLOALKYLCARBONYL, BENZOYL OPTIONALLY SUBSTITUTED WITH HALOGEN, C1-C4 ALKYL, C1-C4 ALCOXY, AMONG OTHERS; NR1R2 IS 2-OXO-4,5-DIHYDROOXAZOLIDIN-3-ILO. THE COMPOUNDS OF FORMULA I HAVE AFFINITY FOR TYPE D3 DOPAMINERGIC RECEPTORS, MODERATE AFFINITY OF TYPE D2 AND 5-HT1A AND MAY BE USEFUL FOR THE TREATMENT OF PSYCHOSIS, SCHIZOPHRENIA, ANXIETY, PANIC, PHOBOSIVE, OBSESSIVE DISORDERS

PE2000000275A 1999-03-30 2000-03-30 DERIVATIVES OF N- [2- (4-AMINOPHENIL) ETHYL] -2,3-DIHYDRO-1,4-BENZODIOXIN-2-METANAMINA PE20001598A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9903936A FR2791675B1 (en) 1999-03-30 1999-03-30 DERIVATIVES OF N- [2- (4-AMINOPHENYL) ETHYL] -2,3-DIHYDRO-1,4- BENZODIOXINNE-2-METHANAMINE, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

Publications (1)

Publication Number Publication Date
PE20001598A1 true PE20001598A1 (en) 2001-04-01

Family

ID=9543788

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2000000275A PE20001598A1 (en) 1999-03-30 2000-03-30 DERIVATIVES OF N- [2- (4-AMINOPHENIL) ETHYL] -2,3-DIHYDRO-1,4-BENZODIOXIN-2-METANAMINA

Country Status (6)

Country Link
AU (1) AU3660700A (en)
CO (1) CO5170535A1 (en)
FR (1) FR2791675B1 (en)
PE (1) PE20001598A1 (en)
UY (1) UY26085A1 (en)
WO (1) WO2000058301A1 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0117396D0 (en) 2001-07-17 2001-09-05 Glaxo Group Ltd Chemical compounds
GB0308208D0 (en) 2003-04-09 2003-05-14 Glaxo Group Ltd Chemical compounds
WO2006089053A2 (en) 2005-02-17 2006-08-24 Wyeth Cycloalkylfused indole, benzothiophene, benzofuran and indene derivatives
AR056320A1 (en) 2005-04-22 2007-10-03 Wyeth Corp CHROMAN AND CHROME DERIVATIVES, OBTAINING PROCESSES, PHARMACEUTICAL COMPOSITIONS AND USES OF THE SAME
JP2008538575A (en) * 2005-04-22 2008-10-30 ワイス Benzodioxane and benzodioxolane derivatives and their use
AR060493A1 (en) * 2006-04-18 2008-06-18 Wyeth Corp DERIVATIVES OF BENZODIOXAN AND BENZODIOXOLAN. OBTAINING PROCESSES.
AR063373A1 (en) * 2006-10-24 2009-01-21 Wyeth Corp DERIVATIVES OF BENZODIOXAN AND ITS USES
JP5548853B2 (en) 2008-04-29 2014-07-16 インテグレイティブ・リサーチ・ラボラトリーズ・スウェーデン・アーベー Modulator of dopamine neurotransmission
AU2009242092A1 (en) 2008-04-29 2009-11-05 Nsab, Filial Af Neurosearch Sweden Ab, Sverige Modulators of dopamine neurotransmission
JP2011519839A (en) * 2008-04-29 2011-07-14 エヌエスエイビー、フィリアル アヴ ノイロサーチ スウェーデン エービー、スヴェーリエ Modulator of dopamine neurotransmission

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL281245A (en) * 1962-07-20
CA1147342A (en) * 1977-10-12 1983-05-31 Kazuo Imai Process of producing novel phenylethanolamine derivatives

Also Published As

Publication number Publication date
UY26085A1 (en) 2000-10-31
WO2000058301A1 (en) 2000-10-05
AU3660700A (en) 2000-10-16
CO5170535A1 (en) 2002-06-27
FR2791675B1 (en) 2001-05-04
FR2791675A1 (en) 2000-10-06

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