AR063373A1 - DERIVATIVES OF BENZODIOXAN AND ITS USES - Google Patents

DERIVATIVES OF BENZODIOXAN AND ITS USES

Info

Publication number
AR063373A1
AR063373A1 ARP070104705A ARP070104705A AR063373A1 AR 063373 A1 AR063373 A1 AR 063373A1 AR P070104705 A ARP070104705 A AR P070104705A AR P070104705 A ARP070104705 A AR P070104705A AR 063373 A1 AR063373 A1 AR 063373A1
Authority
AR
Argentina
Prior art keywords
hydrogen
carbon
lower alkyl
taken together
attached
Prior art date
Application number
ARP070104705A
Other languages
Spanish (es)
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of AR063373A1 publication Critical patent/AR063373A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

En la presente se describen compuestos de formula (1) que son agonistas o agonistas parciales del subtipo 2C de receptores de serotonina de cerebro. Dichos compuestos, y sus composiciones, son utiles para tratar una variedad de trastornos del SNC, tales como la esquizofrenia. Reivindicacion 1: Un compuesto de formula (1), o una sal farmacéuticamente aceptable de dicho compuesto, donde: cada grupo === independientemente representa un enlace simple o doble; R1 es hidrogeno, alquilo inferior, - S(O)2OH o -C(O)R, donde R es hidrogeno o alquilo inferior opcionalmente sustituido con -OH; A es -N(H)-, -N(OH)- o -O-; R2 es hidrogeno o -OH; cada uno de R3 y R4 es independientemente hidrogeno, halogeno, metilo, metoxi o -OH; Ra es hidrogeno o -OH y Rb es hidrogeno o -OH, o Ra y Rb se toman junto con el carbono al cual están unidos para formar un resto carbonilo; Rc es hidrogeno o -OH, y Rd es hidrogeno o -OH, o Rc y Rd se toman junto con el carbono al cual están unidos para formar un resto carbonilo; Re es hidrogeno o -OH; cada Rx es independientemente hidrogeno, halogeno, -CF3 o alquilo inferior, con la condicion de que ambos grupos Rx no sean simultáneamente hidrogeno; cada Ry es independientemente hidrogeno o -OH; m es uno, dos o tres; y n es uno o dos; con la condicion de que se aplique al menos uno de los siguientes puntos: (a) uno de R2, R3, R4, Ra, Rb, Rc, Rd y Ry es -OH; (b) R1 es -C(O)R; (c) R1 es -S(O)2OH; o (d) al menos un par de Ra y Rb o Rc y Rd se toman junto con el carbono al cual están unidos para formar un resto carbonilo.Compounds of formula (1) that are partial agonists or agonists of the 2C subtype of brain serotonin receptors are described herein. Such compounds, and their compositions, are useful for treating a variety of CNS disorders, such as schizophrenia. Claim 1: A compound of formula (1), or a pharmaceutically acceptable salt of said compound, wherein: each group === independently represents a single or double bond; R1 is hydrogen, lower alkyl, -S (O) 2OH or -C (O) R, where R is hydrogen or lower alkyl optionally substituted with -OH; A is -N (H) -, -N (OH) - or -O-; R2 is hydrogen or -OH; each of R3 and R4 is independently hydrogen, halogen, methyl, methoxy or -OH; Ra is hydrogen or -OH and Rb is hydrogen or -OH, or Ra and Rb are taken together with the carbon to which they are attached to form a carbonyl moiety; Rc is hydrogen or -OH, and Rd is hydrogen or -OH, or Rc and Rd are taken together with the carbon to which they are attached to form a carbonyl moiety; Re is hydrogen or -OH; each Rx is independently hydrogen, halogen, -CF3 or lower alkyl, with the proviso that both Rx groups are not simultaneously hydrogen; each Ry is independently hydrogen or -OH; m is one, two or three; and n is one or two; with the proviso that at least one of the following points applies: (a) one of R2, R3, R4, Ra, Rb, Rc, Rd and Ry is -OH; (b) R1 is -C (O) R; (c) R1 is -S (O) 2OH; or (d) at least one pair of Ra and Rb or Rc and Rd are taken together with the carbon to which they are attached to form a carbonyl moiety.

ARP070104705A 2006-10-24 2007-10-24 DERIVATIVES OF BENZODIOXAN AND ITS USES AR063373A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US85405506P 2006-10-24 2006-10-24

Publications (1)

Publication Number Publication Date
AR063373A1 true AR063373A1 (en) 2009-01-21

Family

ID=38941237

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP070104705A AR063373A1 (en) 2006-10-24 2007-10-24 DERIVATIVES OF BENZODIOXAN AND ITS USES

Country Status (4)

Country Link
AR (1) AR063373A1 (en)
CL (1) CL2007003065A1 (en)
TW (1) TW200823187A (en)
WO (1) WO2008052086A1 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2216023A4 (en) 2007-11-15 2013-03-13 Takeda Pharmaceutical Condensed pyridine derivative and use thereof
US20120253036A1 (en) 2009-12-11 2012-10-04 Yukinori Nagakura Agent for treating fibromyalgia
WO2012030953A1 (en) 2010-09-01 2012-03-08 Arena Pharmaceuticals, Inc. 5-ht2c receptor agonists in the treatment of disorders ameliorated by reduction of norepinephrine level
CA2866471A1 (en) 2012-03-06 2013-09-12 Boehringer Ingelheim International Gmbh Benzodioxanes in combination with other actives for inhibiting leukotriene production
JP6256467B2 (en) 2012-07-17 2018-01-10 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Pyrazole derivatives that inhibit leukotriene formation
WO2015009611A1 (en) 2013-07-15 2015-01-22 Boehringer Ingelheim International Gmbh Inhibitors of leukotriene production
EP3022193B1 (en) 2013-07-15 2017-04-26 Boehringer Ingelheim International GmbH Inhibitors of leukotriene production
WO2015066344A1 (en) 2013-11-01 2015-05-07 Arena Pharmaceuticals, Inc. 5-ht2c receptor agonists and compositions and methods of use
GB201801128D0 (en) 2018-01-24 2018-03-07 Univ Oxford Innovation Ltd Compounds
CN112714762A (en) 2018-08-06 2021-04-27 奥尔德拉医疗公司 Polymorphic compounds and uses thereof
EP3962894A4 (en) 2019-05-02 2023-01-11 Aldeyra Therapeutics, Inc. Polymorphic compounds and uses thereof
WO2021231792A1 (en) 2020-05-13 2021-11-18 Aldeyra Therapeutics, Inc. Pharmaceutical formulations and uses thereof
KR20240032926A (en) * 2021-07-02 2024-03-12 알데이라 테라퓨틱스, 아이엔씨. Heterocyclic aldehyde trapping compounds and uses thereof
US11957671B2 (en) 2021-11-01 2024-04-16 Alkahest, Inc. Benzodioxane modulators of leukotriene A4 hydrolase (LTA4H) for prevention and treatment of aging-associated diseases

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2791675B1 (en) * 1999-03-30 2001-05-04 Synthelabo DERIVATIVES OF N- [2- (4-AMINOPHENYL) ETHYL] -2,3-DIHYDRO-1,4- BENZODIOXINNE-2-METHANAMINE, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
JP2003506370A (en) * 1999-07-29 2003-02-18 イーライ・リリー・アンド・カンパニー Benzofurylpiperazine serotonin agonist
AR038762A1 (en) * 2000-10-16 2005-01-26 Hoffmann La Roche DERIVATIVES OF INDOLINA, A PROCESS FOR THE PREPARATION, PHARMACEUTICAL COMPOSITION, PROCESS FOR THE PREPARATION OF SUCH COMPOSITION AND THE USE OF SUCH DERIVATIVES FOR THE MANUFACTURE OF A MEDICINAL PRODUCT
SE0201544D0 (en) * 2002-05-17 2002-05-17 Biovitrum Ab Novel compounds and thier use
CN101218223A (en) * 2005-04-22 2008-07-09 惠氏公司 Benzodioxane and benzodioxolane derivatives and uses thereof

Also Published As

Publication number Publication date
CL2007003065A1 (en) 2008-01-25
TW200823187A (en) 2008-06-01
WO2008052086A1 (en) 2008-05-02

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