PE20001287A1 - PHARMACEUTICAL COMPOSITION CONTAINING DNA FRAGMENTS ENCODING AN ANTIGENIC PROTEIN WITH ANTITUMORAL EFFECT - Google Patents
PHARMACEUTICAL COMPOSITION CONTAINING DNA FRAGMENTS ENCODING AN ANTIGENIC PROTEIN WITH ANTITUMORAL EFFECTInfo
- Publication number
- PE20001287A1 PE20001287A1 PE1999001068A PE00106899A PE20001287A1 PE 20001287 A1 PE20001287 A1 PE 20001287A1 PE 1999001068 A PE1999001068 A PE 1999001068A PE 00106899 A PE00106899 A PE 00106899A PE 20001287 A1 PE20001287 A1 PE 20001287A1
- Authority
- PE
- Peru
- Prior art keywords
- dna
- sequence
- muc
- nucleotides
- pharmaceutical composition
- Prior art date
Links
- 239000012634 fragment Substances 0.000 title abstract 4
- 230000000259 anti-tumor effect Effects 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 102000004169 proteins and genes Human genes 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 title abstract 2
- 230000000890 antigenic effect Effects 0.000 title 1
- 108020004414 DNA Proteins 0.000 abstract 5
- 239000002773 nucleotide Substances 0.000 abstract 3
- 102000004127 Cytokines Human genes 0.000 abstract 2
- 108090000695 Cytokines Proteins 0.000 abstract 2
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 2
- 241000588724 Escherichia coli Species 0.000 abstract 1
- 102000044159 Ubiquitin Human genes 0.000 abstract 1
- 108090000848 Ubiquitin Proteins 0.000 abstract 1
- 239000002671 adjuvant Substances 0.000 abstract 1
- 239000013604 expression vector Substances 0.000 abstract 1
- 230000004927 fusion Effects 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 239000013612 plasmid Substances 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4727—Mucins, e.g. human intestinal mucin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001136—Cytokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Mycology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE CONTIENE ADN QUE CODIFICA FRAGMENTOS DE UNA PROTEINA; COMO MUCINA (MUC-1); SOBREEXPRESADA EN CELULAS TUMORALES CON EL FIN DE INDUCIR UNA RESPUESTA INMUNOLOGICA ANTITUMORAL ANTIGENO ESPECIFICA EN COMBINACION CON EXCIPIENTES Y ADYUVANTES; DE PREFERENCIA CONTIENEN 2, 3, 4 MOLECULAS DE ADN, ADN PLASMIDICO, CADA UNA DE LAS CUALES CONTIENE UNA SECUENCIA DE ADN DE 200 A 700 NUCLEOTIDOS; QUE CODIFICA UN FRAGMENTO DE MUCINA (MUC-1); SIENDO LAS SECUENCIAS DE ADN DE 200 A 700 NUCLEOTIDOS, SIENDO CADA SECUENCIA CONTIGUA Y PARCIALMENTE SUPERPUESTA EN 50 A 150 NUCLEOTIDOS EN EL EXTREMO 3` Y/O 5' CON RESPECTO A LA SECUENCIA ADYACENTE; TAMBIEN SE REFIERE A UN ADN PLASMIDICO QUE DERIVA DE LA FUSION DEL VECTOR DE EXPRESION pMRS30 CON LAS SECUENCIAS QUE CODIFICA UN FRAGMENTO DE LA PROTEINA MUC-1 DE 181, 496, 631, 271 DE BASES, LAS QUE ESTAN PRECEDIDAS EN EL EXTREMO 5' POR LA SECUENCIA DE 361 BASES CODIFICADORA DE UBIQUITINA Y UNA PORCION LACL DE ESCHERICHIA COLI, LA COMPOSICION CONTIENE ADEMAS UNA CITOQUINA O UN PLASMIDO CODIFICADOR DE CITOQUINA Y PUEDE SER UTIL COMO VACUNAS DE ADN ANTITUMORALREFERS TO A PHARMACEUTICAL COMPOSITION CONTAINING DNA THAT CODES FRAGMENTS OF A PROTEIN; AS MUCIN (MUC-1); OVER EXPRESSED IN TUMOR CELLS IN ORDER TO INDUCE A SPECIFIC ANTI-TUMORAL IMMUNOLOGICAL RESPONSE IN COMBINATION WITH EXCIPIENTS AND ADJUVANTS; PREFERREDLY CONTAINS 2, 3, 4 DNA MOLECULES, PLASMIDIC DNA, EACH OF WHICH CONTAINS A DNA SEQUENCE OF 200 TO 700 NUCLEOTIDES; WHICH CODES A FRAGMENT OF MUCINE (MUC-1); BEING THE DNA SEQUENCES FROM 200 TO 700 NUCLEOTIDES, EACH SEQUENCE BEING CONTIGUOUS AND PARTIALLY SUPERPOSED BY 50 TO 150 NUCLEOTIDES AT THE 3` AND / OR 5 'END WITH RESPECT TO THE ADJACENT SEQUENCE; IT ALSO REFERS TO A PLASMIDIC DNA THAT IS DERIVED FROM THE FUSION OF THE EXPRESSION VECTOR pMRS30 WITH THE SEQUENCES THAT CODE A FRAGMENT OF THE MUC-1 PROTEIN OF 181, 496, 631, 271 OF BASES, WHICH ARE PRECEDED IN THE END 5 ' BY THE SEQUENCE OF 361 UBIQUITIN ENCODING BASES AND A LACL PORTION OF ESCHERICHIA COLI, THE COMPOSITION ALSO CONTAINS A CYTOKINE OR CYTOKINE ENCODING PLASMID AND MAY BE USEFUL AS ANTI-TUMOR DNA VACCINES
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1998MI002330A IT1303683B1 (en) | 1998-10-30 | 1998-10-30 | PHARMACEUTICAL COMPOSITION WITH ANTI-TUMORAL ACTION CONTAINING DNACODIFIER FOR FRAGMENTS OF AN ANTIGENIC PROTEIN. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20001287A1 true PE20001287A1 (en) | 2000-12-07 |
Family
ID=11380969
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1999001068A PE20001287A1 (en) | 1998-10-30 | 1999-10-22 | PHARMACEUTICAL COMPOSITION CONTAINING DNA FRAGMENTS ENCODING AN ANTIGENIC PROTEIN WITH ANTITUMORAL EFFECT |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP1124956A2 (en) |
| JP (1) | JP2002528519A (en) |
| CN (1) | CN1324406A (en) |
| AR (1) | AR020927A1 (en) |
| AU (1) | AU1152200A (en) |
| BG (1) | BG105458A (en) |
| BR (1) | BR9914892A (en) |
| CA (1) | CA2348745A1 (en) |
| CO (1) | CO5231134A1 (en) |
| CZ (1) | CZ20011521A3 (en) |
| EA (1) | EA200100395A1 (en) |
| HU (1) | HUP0103784A2 (en) |
| IT (1) | IT1303683B1 (en) |
| MX (1) | MXPA01004186A (en) |
| PE (1) | PE20001287A1 (en) |
| PL (1) | PL348156A1 (en) |
| SK (1) | SK5712001A3 (en) |
| TR (1) | TR200101141T2 (en) |
| WO (1) | WO2000025827A2 (en) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6548643B1 (en) | 1994-11-16 | 2003-04-15 | Austin Research Institute | Antigen carbohydrate compounds and their use in immunotherapy |
| JP2003533181A (en) * | 2000-02-01 | 2003-11-11 | ジ・オースティン・リサーチ・インスティテュート | Mucin-1 derived antigen and its use in immunotherapy |
| DE60140461D1 (en) * | 2000-09-11 | 2009-12-24 | Genzyme Corp | MUC1 EXTRACELLULAR DOMAIN AND COMPOSITIONS FOR CANCER TREATMENT, AND DERIVED PROCEDURES THEREOF |
| EP1958642A1 (en) | 2000-12-22 | 2008-08-20 | Dana-Farber Cancer Institute | Regulation of cell growth by MUC1 |
| EP1622648B1 (en) * | 2003-03-24 | 2010-06-30 | The Scripps Research Institute | Dna vaccines against tumor growth and methods of use thereof |
| US7696306B2 (en) | 2003-07-11 | 2010-04-13 | Board of Agents of the University of Nebraska | Compositions and methods for preventing or treating cancer |
| US8129506B2 (en) | 2003-10-24 | 2012-03-06 | Genzyme Corporation | Modulation of the interaction of MUC1 with MUC1 ligands |
| WO2008097844A2 (en) | 2007-02-02 | 2008-08-14 | Dana -Farber Cancer Institute, Inc. | Methods and compositions relating to the regulation of apoptosis by muc1 and bh3- containing proapoptotic proteins |
| US7972870B2 (en) | 2007-02-02 | 2011-07-05 | Dana-Farber Cancer Institute, Inc. | Methods and compositions relating to the regulation of MUC1 by HSF1 and STAT3 |
| CN106279435B (en) * | 2016-08-16 | 2019-06-07 | 新乡医学院 | Target anti-tumor vaccine, encoding gene, expression vector, expression engineering bacteria and the application of VEGF and mucin1 |
| CN114230655A (en) * | 2021-03-24 | 2022-03-25 | 深圳市新靶向生物科技有限公司 | Antigenic peptide combination related to esophageal cancer driver gene mutation and application thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1262545B (en) * | 1993-10-25 | 1996-07-02 | Menarini Ricerche Sud S P A A | EXPRESSION SYSTEM FOR EUKARYOTIC CELL LINES |
| AU727308B2 (en) * | 1997-02-24 | 2000-12-07 | Dana-Farber Cancer Institute | Recombinant pox virus for immunization against muc1 tumor-associated antigen |
-
1998
- 1998-10-30 IT IT1998MI002330A patent/IT1303683B1/en active
-
1999
- 1999-10-18 WO PCT/EP1999/007874 patent/WO2000025827A2/en not_active Application Discontinuation
- 1999-10-18 BR BR9914892-7A patent/BR9914892A/en not_active IP Right Cessation
- 1999-10-18 HU HU0103784A patent/HUP0103784A2/en unknown
- 1999-10-18 EA EA200100395A patent/EA200100395A1/en unknown
- 1999-10-18 SK SK571-2001A patent/SK5712001A3/en unknown
- 1999-10-18 CN CN99812745A patent/CN1324406A/en active Pending
- 1999-10-18 AU AU11522/00A patent/AU1152200A/en not_active Abandoned
- 1999-10-18 MX MXPA01004186A patent/MXPA01004186A/en unknown
- 1999-10-18 TR TR2001/01141T patent/TR200101141T2/en unknown
- 1999-10-18 PL PL99348156A patent/PL348156A1/en unknown
- 1999-10-18 EP EP99971329A patent/EP1124956A2/en not_active Withdrawn
- 1999-10-18 CZ CZ20011521A patent/CZ20011521A3/en unknown
- 1999-10-18 JP JP2000579265A patent/JP2002528519A/en active Pending
- 1999-10-18 CA CA002348745A patent/CA2348745A1/en not_active Abandoned
- 1999-10-21 AR ARP990105316A patent/AR020927A1/en unknown
- 1999-10-22 PE PE1999001068A patent/PE20001287A1/en not_active Application Discontinuation
- 1999-10-29 CO CO99068636A patent/CO5231134A1/en not_active Application Discontinuation
-
2001
- 2001-04-20 BG BG105458A patent/BG105458A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL348156A1 (en) | 2002-05-06 |
| JP2002528519A (en) | 2002-09-03 |
| BR9914892A (en) | 2001-07-17 |
| TR200101141T2 (en) | 2001-09-21 |
| MXPA01004186A (en) | 2002-06-04 |
| AR020927A1 (en) | 2002-06-05 |
| SK5712001A3 (en) | 2002-04-04 |
| EP1124956A2 (en) | 2001-08-22 |
| CO5231134A1 (en) | 2002-12-27 |
| IT1303683B1 (en) | 2001-02-23 |
| AU1152200A (en) | 2000-05-22 |
| BG105458A (en) | 2002-06-28 |
| ITMI982330A0 (en) | 1998-10-30 |
| ITMI982330A1 (en) | 2000-04-30 |
| CZ20011521A3 (en) | 2001-10-17 |
| EA200100395A1 (en) | 2001-10-22 |
| HUP0103784A2 (en) | 2002-02-28 |
| WO2000025827A2 (en) | 2000-05-11 |
| WO2000025827A3 (en) | 2000-08-10 |
| CN1324406A (en) | 2001-11-28 |
| CA2348745A1 (en) | 2000-05-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |