BG105458A - Dna molecules encoding muc-1 and use thereof in tumor vaccination - Google Patents

Dna molecules encoding muc-1 and use thereof in tumor vaccination

Info

Publication number
BG105458A
BG105458A BG105458A BG10545801A BG105458A BG 105458 A BG105458 A BG 105458A BG 105458 A BG105458 A BG 105458A BG 10545801 A BG10545801 A BG 10545801A BG 105458 A BG105458 A BG 105458A
Authority
BG
Bulgaria
Prior art keywords
dna molecules
molecules encoding
tumor vaccination
encoding muc
tumor
Prior art date
Application number
BG105458A
Other languages
Bulgarian (bg)
Inventor
Dino Parente
MASSIMO Anna Maria DI
Santis Rita De
Original Assignee
Menarini Ricerche S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Menarini Ricerche S.P.A. filed Critical Menarini Ricerche S.P.A.
Publication of BG105458A publication Critical patent/BG105458A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4727—Mucins, e.g. human intestinal mucin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001136—Cytokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Mycology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Provided is a pharmaceutical composition containing one or more DNA molecules encoding fragments of a protein overexpressed in tumor cells, in order to induce an anti-tumor Ag-specific immune response, in association with suitable excipients and adjuvants. 16 claims
BG105458A 1998-10-30 2001-04-20 Dna molecules encoding muc-1 and use thereof in tumor vaccination BG105458A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT1998MI002330A IT1303683B1 (en) 1998-10-30 1998-10-30 PHARMACEUTICAL COMPOSITION WITH ANTI-TUMORAL ACTION CONTAINING DNACODIFIER FOR FRAGMENTS OF AN ANTIGENIC PROTEIN.
PCT/EP1999/007874 WO2000025827A2 (en) 1998-10-30 1999-10-18 Dna molecules encoding muc-1 and use thereof in tumor vaccination

Publications (1)

Publication Number Publication Date
BG105458A true BG105458A (en) 2002-06-28

Family

ID=11380969

Family Applications (1)

Application Number Title Priority Date Filing Date
BG105458A BG105458A (en) 1998-10-30 2001-04-20 Dna molecules encoding muc-1 and use thereof in tumor vaccination

Country Status (19)

Country Link
EP (1) EP1124956A2 (en)
JP (1) JP2002528519A (en)
CN (1) CN1324406A (en)
AR (1) AR020927A1 (en)
AU (1) AU1152200A (en)
BG (1) BG105458A (en)
BR (1) BR9914892A (en)
CA (1) CA2348745A1 (en)
CO (1) CO5231134A1 (en)
CZ (1) CZ20011521A3 (en)
EA (1) EA200100395A1 (en)
HU (1) HUP0103784A2 (en)
IT (1) IT1303683B1 (en)
MX (1) MXPA01004186A (en)
PE (1) PE20001287A1 (en)
PL (1) PL348156A1 (en)
SK (1) SK5712001A3 (en)
TR (1) TR200101141T2 (en)
WO (1) WO2000025827A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6548643B1 (en) 1994-11-16 2003-04-15 Austin Research Institute Antigen carbohydrate compounds and their use in immunotherapy
JP2003533181A (en) * 2000-02-01 2003-11-11 ジ・オースティン・リサーチ・インスティテュート Mucin-1 derived antigen and its use in immunotherapy
DE60140461D1 (en) * 2000-09-11 2009-12-24 Genzyme Corp MUC1 EXTRACELLULAR DOMAIN AND COMPOSITIONS FOR CANCER TREATMENT, AND DERIVED PROCEDURES THEREOF
EP1958642A1 (en) 2000-12-22 2008-08-20 Dana-Farber Cancer Institute Regulation of cell growth by MUC1
EP1622648B1 (en) * 2003-03-24 2010-06-30 The Scripps Research Institute Dna vaccines against tumor growth and methods of use thereof
US7696306B2 (en) 2003-07-11 2010-04-13 Board of Agents of the University of Nebraska Compositions and methods for preventing or treating cancer
US8129506B2 (en) 2003-10-24 2012-03-06 Genzyme Corporation Modulation of the interaction of MUC1 with MUC1 ligands
WO2008097844A2 (en) 2007-02-02 2008-08-14 Dana -Farber Cancer Institute, Inc. Methods and compositions relating to the regulation of apoptosis by muc1 and bh3- containing proapoptotic proteins
US7972870B2 (en) 2007-02-02 2011-07-05 Dana-Farber Cancer Institute, Inc. Methods and compositions relating to the regulation of MUC1 by HSF1 and STAT3
CN106279435B (en) * 2016-08-16 2019-06-07 新乡医学院 Target anti-tumor vaccine, encoding gene, expression vector, expression engineering bacteria and the application of VEGF and mucin1
CN114230655A (en) * 2021-03-24 2022-03-25 深圳市新靶向生物科技有限公司 Antigenic peptide combination related to esophageal cancer driver gene mutation and application thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1262545B (en) * 1993-10-25 1996-07-02 Menarini Ricerche Sud S P A A EXPRESSION SYSTEM FOR EUKARYOTIC CELL LINES
AU727308B2 (en) * 1997-02-24 2000-12-07 Dana-Farber Cancer Institute Recombinant pox virus for immunization against muc1 tumor-associated antigen

Also Published As

Publication number Publication date
PL348156A1 (en) 2002-05-06
JP2002528519A (en) 2002-09-03
BR9914892A (en) 2001-07-17
TR200101141T2 (en) 2001-09-21
MXPA01004186A (en) 2002-06-04
AR020927A1 (en) 2002-06-05
SK5712001A3 (en) 2002-04-04
EP1124956A2 (en) 2001-08-22
CO5231134A1 (en) 2002-12-27
PE20001287A1 (en) 2000-12-07
IT1303683B1 (en) 2001-02-23
AU1152200A (en) 2000-05-22
ITMI982330A0 (en) 1998-10-30
ITMI982330A1 (en) 2000-04-30
CZ20011521A3 (en) 2001-10-17
EA200100395A1 (en) 2001-10-22
HUP0103784A2 (en) 2002-02-28
WO2000025827A2 (en) 2000-05-11
WO2000025827A3 (en) 2000-08-10
CN1324406A (en) 2001-11-28
CA2348745A1 (en) 2000-05-11

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