PE123599A1 - DERIVATIVES OF BIPHENYL - Google Patents

DERIVATIVES OF BIPHENYL

Info

Publication number
PE123599A1
PE123599A1 PE1998001034A PE00103498A PE123599A1 PE 123599 A1 PE123599 A1 PE 123599A1 PE 1998001034 A PE1998001034 A PE 1998001034A PE 00103498 A PE00103498 A PE 00103498A PE 123599 A1 PE123599 A1 PE 123599A1
Authority
PE
Peru
Prior art keywords
alkyl
alcoxy
compound
refers
group
Prior art date
Application number
PE1998001034A
Other languages
Spanish (es)
Inventor
Robert Swoboda
Esteban Pombo Villar
Manuel Koller
Silvio Ofner
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9723134.4A external-priority patent/GB9723134D0/en
Priority claimed from GBGB9723133.6A external-priority patent/GB9723133D0/en
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PE123599A1 publication Critical patent/PE123599A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/29—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
    • C07C217/60—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms linked by carbon chains having two carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I DONDE R1 Y R2 SON H, ALQUILO C1-C4, ALCOXI C1-C4, ENTRE OTROS; R3 ES H, OH, ALQUILO C1-C4, ALCOXI C1-C4, ENTRE OTROS; R4 ES H, OH, ALCOXI C1-C4; R5 ES UN GRUPO a, b, c, -X-N(R7)(R8); R6 ES ALQUILO C1-C4: X ES ALQUILENO C1-C4; R7 Y R8 SON H, ALQUILO C1-C4, HIDROXIALQUILO C2-C4, FENILALQUILO C1-C4, O FORMAN JUNTO CON N PIRROLIDINILO, PIPERIDINO, PIPERAZINILO O MORFOLINO O UN GRUPO e; Z ES O, CH2, CH2-CH2; R9, R10, R11, R12, R13 Y R14 SON H, HALOGENO, ALQUILO C1-C4, ALCOXI C1-C4. UN COMPUESTO PREFERIDO ES (+)-3-(4-METOXI-4`-TRIFLUOROMETIL-BIFENIL-3-IL)-1-PROPILPIPERIDINA, ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. EL COMPUESTO I PUEDE SER UTIL PARA EL TRATAMIENTO DE EPILEPSIA, EMBOLIA Y TRAUMA CEREBRAL O ESPINALIT REFERS TO A COMPOUND OF FORMULA I WHERE R1 AND R2 ARE H, ALKYL C1-C4, ALCOXI C1-C4, AMONG OTHERS; R3 IS H, OH, C1-C4 ALKYL, C1-C4 ALCOXY, AMONG OTHERS; R4 IS H, OH, C1-C4 ALCOXY; R5 IS A GROUP a, b, c, -X-N (R7) (R8); R6 IS C1-C4 ALKYL: X IS C1-C4 ALKYLENE; R7 AND R8 ARE H, C1-C4 ALKYL, C2-C4 HYDROXYALKYL, C1-C4 PHENYLALKYL, OR FORM TOGETHER WITH N PIRROLIDINYL, PIPERIDINE, PIPERAZINYL OR MORPHOLINE OR A GROUP e; Z ES O, CH2, CH2-CH2; R9, R10, R11, R12, R13 AND R14 ARE H, HALOGEN, C1-C4 ALKYL, C1-C4 ALCOXY. A PREFERRED COMPOUND IS (+) - 3- (4-METOXI-4`-TRIFLUOROMETIL-BIFENIL-3-IL) -1-PROPILPIPERIDINA, AMONG OTHERS. IT ALSO REFERS TO A PROCEDURE FOR PREPARATION. COMPOUND I MAY BE USEFUL FOR THE TREATMENT OF EPILEPSY, EMBOLIA AND BRAIN OR SPINAL TRAUMA

PE1998001034A 1997-11-03 1998-11-02 DERIVATIVES OF BIPHENYL PE123599A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9723134.4A GB9723134D0 (en) 1997-11-03 1997-11-03 Organic compounds
GBGB9723133.6A GB9723133D0 (en) 1997-11-03 1997-11-03 Organic compounds

Publications (1)

Publication Number Publication Date
PE123599A1 true PE123599A1 (en) 1999-12-20

Family

ID=26312535

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1998001034A PE123599A1 (en) 1997-11-03 1998-11-02 DERIVATIVES OF BIPHENYL

Country Status (18)

Country Link
EP (1) EP1037876A1 (en)
JP (1) JP2001521923A (en)
KR (1) KR20010031699A (en)
CN (1) CN1278249A (en)
AR (1) AR016148A1 (en)
AU (1) AU740448B2 (en)
BR (1) BR9813897A (en)
CA (1) CA2308151A1 (en)
CO (1) CO5011067A1 (en)
ID (1) ID24413A (en)
IL (1) IL135580A0 (en)
NO (1) NO20002321D0 (en)
NZ (1) NZ503815A (en)
PE (1) PE123599A1 (en)
PL (1) PL339922A1 (en)
SK (1) SK6412000A3 (en)
TR (1) TR200001122T2 (en)
WO (1) WO1999023073A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6858592B2 (en) 2001-06-29 2005-02-22 Genzyme Corporation Aryl boronic acids for treating obesity
US7041280B2 (en) 2001-06-29 2006-05-09 Genzyme Corporation Aryl boronate functionalized polymers for treating obesity
TW200840566A (en) * 2006-12-22 2008-10-16 Esteve Labor Dr Heterocyclyl-substituted-ethylamino-phenyl derivatives, their preparation and use as medicaments
US8575364B2 (en) * 2008-10-30 2013-11-05 Janssen Pharmaceutica Nv Modulators of serotonin receptor
WO2010059393A1 (en) 2008-10-30 2010-05-27 Janssen Pharmaceutica Nv Serotonin receptor modulators
DE102009015697A1 (en) 2009-03-31 2010-10-07 Markus Dr. Heinrich Process for the arylation of ring-substituted phenols and phenyl ethers

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2114122A (en) * 1938-04-12 Alcohols and process fob making
DE674968C (en) * 1935-01-15 1939-04-26 Roehm & Haas Company Process for the preparation of phenolic aralkylamino alcohols
US2040039A (en) * 1935-02-26 1936-05-05 Rohm & Haas Phenolic morpholines
US2485550A (en) * 1946-06-25 1949-10-25 Hoffmann La Roche Quaternary salts of carbamic acid esters of tertiary-hydroxybenzyl-amines
US2493710A (en) * 1947-03-21 1950-01-03 Hoffmann La Roche Carbamic acid esters
US2872477A (en) * 1957-04-05 1959-02-03 Dow Chemical Co alpha-(dialkylamino)-6-phenyl-o-cresol esters
JPS5328150A (en) * 1976-08-25 1978-03-16 Sugai Chemical Ind Co Ltd Novel orthophenyl phenol derivative process for preparing same
CN1029227C (en) * 1989-02-08 1995-07-05 大制药株式会社 Composition for denatured denaturation or protection agent for nerve cell and process for preparing benzene derivatives used for composition
US5428037A (en) * 1993-04-09 1995-06-27 Syntex Pharmaceuticals, Ltd. Heterocyclic derivatives in the treatment of Ischaemia and related diseases
JPH072655A (en) * 1993-06-18 1995-01-06 Otsuka Pharmaceut Co Ltd Agent for repairing or protecting denaturation of peripheral nerve
SI0707007T1 (en) * 1994-10-14 2002-04-30 Merck Patent Gmbh (R)-(-)-2-(5-(4-fluorophenyl)-3-pyridylmethylaminomethyl)chromane as CNS active agent
MX9703671A (en) * 1994-11-23 1997-12-31 Neurogen Corp Aminomethyl aryl compounds; dopamine receptor subtype selective ligands.
IL116249A (en) * 1994-12-12 2003-07-06 Pfizer Nk-1 receptor antagonists for the treatment of neuronal damage and stroke
DE19637237A1 (en) * 1996-09-13 1998-03-19 Merck Patent Gmbh Piperazine derivatives

Also Published As

Publication number Publication date
CN1278249A (en) 2000-12-27
ID24413A (en) 2000-07-20
NO20002321L (en) 2000-05-02
EP1037876A1 (en) 2000-09-27
IL135580A0 (en) 2001-05-20
PL339922A1 (en) 2001-01-15
AR016148A1 (en) 2001-06-20
TR200001122T2 (en) 2000-08-21
NZ503815A (en) 2002-05-31
CA2308151A1 (en) 1999-05-14
NO20002321D0 (en) 2000-05-02
BR9813897A (en) 2000-09-26
KR20010031699A (en) 2001-04-16
AU740448B2 (en) 2001-11-01
WO1999023073A1 (en) 1999-05-14
AU1487299A (en) 1999-05-24
CO5011067A1 (en) 2001-02-28
JP2001521923A (en) 2001-11-13
SK6412000A3 (en) 2000-09-12

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