AR016148A1 - DERIVATIVES OF BIFENYLL, PROCESS FOR ITS PRODUCTION, PHARMACEUTICAL COMPOSITION THAT CONTAINS THEM AND ITS USE FOR THE MANUFACTURE OF A MEDICINAL PRODUCT. - Google Patents

DERIVATIVES OF BIFENYLL, PROCESS FOR ITS PRODUCTION, PHARMACEUTICAL COMPOSITION THAT CONTAINS THEM AND ITS USE FOR THE MANUFACTURE OF A MEDICINAL PRODUCT.

Info

Publication number
AR016148A1
AR016148A1 ARP980105469A ARP980105469A AR016148A1 AR 016148 A1 AR016148 A1 AR 016148A1 AR P980105469 A ARP980105469 A AR P980105469A AR P980105469 A ARP980105469 A AR P980105469A AR 016148 A1 AR016148 A1 AR 016148A1
Authority
AR
Argentina
Prior art keywords
alkyl
alkoxy
hydrogen
independently
manufacture
Prior art date
Application number
ARP980105469A
Other languages
Spanish (es)
Original Assignee
Garcia Cattebeke Cybele Carina
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9723134.4A external-priority patent/GB9723134D0/en
Priority claimed from GBGB9723133.6A external-priority patent/GB9723133D0/en
Application filed by Garcia Cattebeke Cybele Carina filed Critical Garcia Cattebeke Cybele Carina
Publication of AR016148A1 publication Critical patent/AR016148A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/29—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
    • C07C217/60—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms linked by carbon chains having two carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Abstract

Derivados de bifenilo que tienen propiedades anti-convulsivas y neuroprotectoras de la formula I: en donde R1 y R2, independientemente, son hidrogeno,alquilo C1-4, alcoxi C1-4, tioalquilo C1-4, halngeno, trifluorometilo, trifluorometoxi, ciano oalca noílo C2-5, R3 es hidrogeno, hidroxi, alquilo C1-4, alcoxiC1-4, ciclolquiloxi C3-6, halogeno, ciano, alcanoílo C2-5, carbamoílo, alquilo C1-4-sulfoniloxi o trifluorometilsulfoniloxi, R4 es hidrogeno, hidrogri o alcoxiC1-4, y R5 es un grupo dela form ula (a), (b), (c) o (d) en donde: R6 es alquilo C1-4, X es una cadena de alquileno recta o ramificada con C1-4, y R7 y R8,independientemente, son hidrogeno, alquilo C1-4, hidroxialquilo C2-4, o fenilalquilo C1-4, o forman, junto con elátomo de nitr ogeno con el que están unidos,un grupo pirrolidinilo, piperidino, piperazinilo o morfolino, o un grupo de la formula (e): en donde Z es O, CH2 o CH2-CH2, y R9, R10, R11, R12, R13 y R14,independientemente, son H, halogeno, alquilo C1-4,o alcoxi C1-4, en forma de base libre o de sal de adicion de ácido, proceso para su produccion, composicionfarmacéutica que los contiene y su uso para la manufactura de un medicamento. Utiles para la epilepsia y estados convulsivos.Biphenyl derivatives having anti-seizure and neuroprotective properties of formula I: wherein R1 and R2, independently, are hydrogen, C1-4 alkyl, C1-4 alkoxy, C1-4 thioalkyl, halngene, trifluoromethyl, trifluoromethoxy, cyano oalca C2-5, R3 is hydrogen, hydroxy, C1-4 alkyl, C1-4 alkoxy, C3-6 cycloolkyloxy, halogen, cyano, C2-5 alkanoyl, carbamoyl, C1-4-sulfonyloxy alkyl or trifluoromethylsulfonyloxy, R4 is hydrogen, hydrorogri or C1-4 alkoxy, and R5 is a group of the form (a), (b), (c) or (d) where: R6 is C1-4 alkyl, X is a straight or branched alkylene chain with C1- 4, and R7 and R8, independently, are hydrogen, C1-4 alkyl, C2-4 hydroxyalkyl, or C1-4 phenylalkyl, or together with the nitrogen atom lathomene with which they are attached, a pyrrolidinyl, piperidine, piperazinyl group or morpholino, or a group of the formula (e): wherein Z is O, CH2 or CH2-CH2, and R9, R10, R11, R12, R13 and R14, independently, are H, halogen, C1-4 alkyl, or C1 alkoxy -4, in the form of free base or acid addition salt, process for its production, pharmaceutical composition containing them and its use for the manufacture of a medicine. Useful for epilepsy and seizure states.

ARP980105469A 1997-11-03 1998-10-30 DERIVATIVES OF BIFENYLL, PROCESS FOR ITS PRODUCTION, PHARMACEUTICAL COMPOSITION THAT CONTAINS THEM AND ITS USE FOR THE MANUFACTURE OF A MEDICINAL PRODUCT. AR016148A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9723134.4A GB9723134D0 (en) 1997-11-03 1997-11-03 Organic compounds
GBGB9723133.6A GB9723133D0 (en) 1997-11-03 1997-11-03 Organic compounds

Publications (1)

Publication Number Publication Date
AR016148A1 true AR016148A1 (en) 2001-06-20

Family

ID=26312535

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP980105469A AR016148A1 (en) 1997-11-03 1998-10-30 DERIVATIVES OF BIFENYLL, PROCESS FOR ITS PRODUCTION, PHARMACEUTICAL COMPOSITION THAT CONTAINS THEM AND ITS USE FOR THE MANUFACTURE OF A MEDICINAL PRODUCT.

Country Status (18)

Country Link
EP (1) EP1037876A1 (en)
JP (1) JP2001521923A (en)
KR (1) KR20010031699A (en)
CN (1) CN1278249A (en)
AR (1) AR016148A1 (en)
AU (1) AU740448B2 (en)
BR (1) BR9813897A (en)
CA (1) CA2308151A1 (en)
CO (1) CO5011067A1 (en)
ID (1) ID24413A (en)
IL (1) IL135580A0 (en)
NO (1) NO20002321L (en)
NZ (1) NZ503815A (en)
PE (1) PE123599A1 (en)
PL (1) PL339922A1 (en)
SK (1) SK6412000A3 (en)
TR (1) TR200001122T2 (en)
WO (1) WO1999023073A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6858592B2 (en) 2001-06-29 2005-02-22 Genzyme Corporation Aryl boronic acids for treating obesity
US7041280B2 (en) 2001-06-29 2006-05-09 Genzyme Corporation Aryl boronate functionalized polymers for treating obesity
TW200840566A (en) * 2006-12-22 2008-10-16 Esteve Labor Dr Heterocyclyl-substituted-ethylamino-phenyl derivatives, their preparation and use as medicaments
US8642583B2 (en) 2008-10-30 2014-02-04 Janssen Pharmaceutica Nv Serotonin receptor modulators
WO2010059390A1 (en) 2008-10-30 2010-05-27 Janssen Pharmaceutica Nv Modulators of serotonin receptor
DE102009015697A1 (en) 2009-03-31 2010-10-07 Markus Dr. Heinrich Process for the arylation of ring-substituted phenols and phenyl ethers

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2114122A (en) * 1938-04-12 Alcohols and process fob making
DE674968C (en) * 1935-01-15 1939-04-26 Roehm & Haas Company Process for the preparation of phenolic aralkylamino alcohols
US2040039A (en) * 1935-02-26 1936-05-05 Rohm & Haas Phenolic morpholines
US2485550A (en) * 1946-06-25 1949-10-25 Hoffmann La Roche Quaternary salts of carbamic acid esters of tertiary-hydroxybenzyl-amines
US2493710A (en) * 1947-03-21 1950-01-03 Hoffmann La Roche Carbamic acid esters
US2872477A (en) * 1957-04-05 1959-02-03 Dow Chemical Co alpha-(dialkylamino)-6-phenyl-o-cresol esters
JPS5328150A (en) * 1976-08-25 1978-03-16 Sugai Chemical Ind Co Ltd Novel orthophenyl phenol derivative process for preparing same
EP0382213B1 (en) * 1989-02-08 1995-05-10 Otsuka Pharmaceutical Co., Ltd. Biphenyl derivative, nerve cell degeneration repairing or protecting agent and process for preparing a phenyl derivative contained in the agent
US5428037A (en) * 1993-04-09 1995-06-27 Syntex Pharmaceuticals, Ltd. Heterocyclic derivatives in the treatment of Ischaemia and related diseases
JPH072655A (en) * 1993-06-18 1995-01-06 Otsuka Pharmaceut Co Ltd Agent for repairing or protecting denaturation of peripheral nerve
PT707007E (en) * 1994-10-14 2002-06-28 Merck Patent Gmbh AMINO DERIVATIVES (TIO) ETER AS ACTIVE AGENTS IN THE CNS
EP0793662A1 (en) * 1994-11-23 1997-09-10 Neurogen Corporation Aminomethyl aryl compounds; dopamine receptor subtype selective ligands
IL116249A (en) * 1994-12-12 2003-07-06 Pfizer Nk-1 receptor antagonists for the treatment of neuronal damage and stroke
DE19637237A1 (en) * 1996-09-13 1998-03-19 Merck Patent Gmbh Piperazine derivatives

Also Published As

Publication number Publication date
TR200001122T2 (en) 2000-08-21
KR20010031699A (en) 2001-04-16
BR9813897A (en) 2000-09-26
CN1278249A (en) 2000-12-27
NZ503815A (en) 2002-05-31
NO20002321D0 (en) 2000-05-02
PL339922A1 (en) 2001-01-15
ID24413A (en) 2000-07-20
JP2001521923A (en) 2001-11-13
IL135580A0 (en) 2001-05-20
WO1999023073A1 (en) 1999-05-14
CA2308151A1 (en) 1999-05-14
CO5011067A1 (en) 2001-02-28
EP1037876A1 (en) 2000-09-27
AU1487299A (en) 1999-05-24
NO20002321L (en) 2000-05-02
AU740448B2 (en) 2001-11-01
PE123599A1 (en) 1999-12-20
SK6412000A3 (en) 2000-09-12

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