PA8827501A1 - Pirrolidin amidas sustituidas como moduladores del receptor histamina h3 - Google Patents

Pirrolidin amidas sustituidas como moduladores del receptor histamina h3

Info

Publication number
PA8827501A1
PA8827501A1 PA20098827501A PA8827501A PA8827501A1 PA 8827501 A1 PA8827501 A1 PA 8827501A1 PA 20098827501 A PA20098827501 A PA 20098827501A PA 8827501 A PA8827501 A PA 8827501A PA 8827501 A1 PA8827501 A1 PA 8827501A1
Authority
PA
Panama
Prior art keywords
pirrolidin
replaced
amidas
histamine
histamine receiver
Prior art date
Application number
PA20098827501A
Other languages
English (en)
Inventor
I Carruthers Nicholas
A Letavic Michael
S Ly Kiev
S Mani Neelakandha
J Pippel Daniel
R Shah Chandravadan
Soyode-Johnson Aki
M Stocking Emily
Young Lana
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of PA8827501A1 publication Critical patent/PA8827501A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

CIERTOS COMPUESTOS PIRROLIDIN AMIDA SUSTITUIDOS CON MODULADORES DEL RECEPTOR HISTAMINA H3 ÚTILES EN EL TRATAMIENTO DE ENFERMEDADES INTERMEDIADAS POR EL RECEPTOR HISTAMINA H3.
PA20098827501A 2008-05-23 2009-05-22 Pirrolidin amidas sustituidas como moduladores del receptor histamina h3 PA8827501A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5553808P 2008-05-23 2008-05-23

Publications (1)

Publication Number Publication Date
PA8827501A1 true PA8827501A1 (es) 2009-12-16

Family

ID=41026372

Family Applications (1)

Application Number Title Priority Date Filing Date
PA20098827501A PA8827501A1 (es) 2008-05-23 2009-05-22 Pirrolidin amidas sustituidas como moduladores del receptor histamina h3

Country Status (8)

Country Link
US (1) US8236792B2 (es)
AR (1) AR071887A1 (es)
CL (1) CL2009001282A1 (es)
PA (1) PA8827501A1 (es)
PE (1) PE20091948A1 (es)
TW (1) TW201008928A (es)
UY (1) UY31840A (es)
WO (1) WO2009143153A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200823204A (en) * 2006-10-17 2008-06-01 Arena Pharm Inc Biphenyl sulfonyl and phenyl-heteroaryl sulfonyl modulators of the histamine H3-receptor useful for the treatment of disorders related thereto
ES2554513T3 (es) 2008-05-23 2015-12-21 Novartis Ag Derivados de quinolinas y quinoxalinas como inhibidores de la proteína tirosina quinasa
US8802864B2 (en) 2010-02-22 2014-08-12 Glaxosmithkline Llc Triazolones as fatty acid synthase inhibitors
WO2013076590A1 (en) 2011-11-23 2013-05-30 Oxygen Healthcare Research Pvt. Ltd Benzothiazine compounds as h3 receptor ligands
CN104876917B (zh) * 2015-06-16 2017-09-19 上海皓元医药股份有限公司 用作脂肪酸合成酶抑制剂的三唑酮的合成方法
GB201518950D0 (en) * 2015-10-27 2015-12-09 Glaxosmithkline Ip Dev Ltd Compound

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2070305A1 (en) * 1991-06-04 1992-12-05 Isao Kawamoto 1-methylcarbapenem derivatives, their preparation and their use as antibiotics
JP3091297B2 (ja) * 1992-01-10 2000-09-25 住友製薬株式会社 ピロリジン誘導体およびその製造方法
WO2002014271A1 (fr) * 2000-08-10 2002-02-21 Mitsubishi Pharma Corporation Dérivés de proline et leur utilisation comme médicaments
US6838479B2 (en) * 2000-09-11 2005-01-04 Genentech, Inc. Amidine inhibitors of serine proteases
US7067507B2 (en) * 2001-06-12 2006-06-27 Pharmacia & Upjohn Company Macrocycles useful in the treatment of Alzheimer's disease
JP2005502623A (ja) 2001-07-02 2005-01-27 ノボ　ノルディスク　アクティーゼルスカブ 置換ピペラジンおよびジアゼパン
GB0324159D0 (en) * 2003-10-15 2003-11-19 Glaxo Group Ltd Novel compounds
SI1802307T1 (sl) 2004-10-15 2008-08-31 Glaxo Group Ltd Derivati pirolidina kot ligandi histaminskih receptorjev
ATE533744T1 (de) * 2006-05-19 2011-12-15 Wyeth Llc N-benzoypyrrolidin-3-ylamine als histamin-3 antagonisten

Also Published As

Publication number Publication date
US8236792B2 (en) 2012-08-07
TW201008928A (en) 2010-03-01
UY31840A (es) 2009-12-14
PE20091948A1 (es) 2009-12-31
AR071887A1 (es) 2010-07-21
US20090291903A1 (en) 2009-11-26
WO2009143153A1 (en) 2009-11-26
CL2009001282A1 (es) 2009-10-23

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