PA8806901A1 - SOLID FUNCTIONED POLYMER NANOPARTICLES THAT INCLUDE EPOTILONES - Google Patents
SOLID FUNCTIONED POLYMER NANOPARTICLES THAT INCLUDE EPOTILONESInfo
- Publication number
- PA8806901A1 PA8806901A1 PA20088806901A PA8806901A PA8806901A1 PA 8806901 A1 PA8806901 A1 PA 8806901A1 PA 20088806901 A PA20088806901 A PA 20088806901A PA 8806901 A PA8806901 A PA 8806901A PA 8806901 A1 PA8806901 A1 PA 8806901A1
- Authority
- PA
- Panama
- Prior art keywords
- substances
- epotilones
- functioned
- solid
- polymer nanoparticles
- Prior art date
Links
- 239000002105 nanoparticle Substances 0.000 title abstract 2
- 229920000642 polymer Polymers 0.000 title abstract 2
- 239000007787 solid Substances 0.000 title 1
- 239000000126 substance Substances 0.000 abstract 3
- 230000000694 effects Effects 0.000 abstract 2
- 239000002245 particle Substances 0.000 abstract 2
- XLYOFNOQVPJJNP-PWCQTSIFSA-N Tritiated water Chemical compound [3H]O[3H] XLYOFNOQVPJJNP-PWCQTSIFSA-N 0.000 abstract 1
- 238000000975 co-precipitation Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000032 diagnostic agent Substances 0.000 abstract 1
- 229940039227 diagnostic agent Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000012874 electrostatic modification Methods 0.000 abstract 1
- 238000005538 encapsulation Methods 0.000 abstract 1
- 230000002209 hydrophobic effect Effects 0.000 abstract 1
- 230000007935 neutral effect Effects 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5138—Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0032—Methine dyes, e.g. cyanine dyes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0032—Methine dyes, e.g. cyanine dyes
- A61K49/0034—Indocyanine green, i.e. ICG, cardiogreen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0039—Coumarin dyes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0054—Macromolecular compounds, i.e. oligomers, polymers, dendrimers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0063—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
- A61K49/0069—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form
- A61K49/0089—Particulate, powder, adsorbate, bead, sphere
- A61K49/0091—Microparticle, microcapsule, microbubble, microsphere, microbead, i.e. having a size or diameter higher or equal to 1 micrometer
- A61K49/0093—Nanoparticle, nanocapsule, nanobubble, nanosphere, nanobead, i.e. having a size or diameter smaller than 1 micrometer, e.g. polymeric nanoparticle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nanotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
SE DESCRIBEN NANOPARTÍCULAS POLIMÉRICAS CON POTENCIAL SUPERFICIAL CATIÓNICO EN LAS CUALES PUEDEN ENCAPSULARSE SUSTANCIAS NEUTRAS, HIDROFÓBICAS E HIDROFÍLICAS CON ACTIVIDAD FARMACÉUTICA. LAS SUSTANCIAS HIDROFÍLICAS, Y POR LO TANTO, SOLUBLES EN AGUA, SE ENCAPSULAN EN LA PARTÍCULA QUE CONSTITUYE EL NÚCLEO POR CO-PRECIPITACIÓN, MEDIANTE LA COMPLEJIZACIÓN IÓNICA CON UN POLÍMERO CARGADO. COMO SUSTANCIAS CON ACTIVIDAD FARMACÉUTICA PARA LA ENCAPSULACIÓN PUEDEN USARSE AGENTES TERAPÉUTICA Y AGENTES DE DIAGNÓSTICO. LA SUPERFICIE CATIÓNICA DE LA PARTÍCULA PERMITE REALIZAR UNA MODIFICACIÓN ELECTROSTÁTICA ESTABLE DE LA SUPERFICIE CON COMPUESTOS CON CARGAS PARCIALMENTE OPUESTAS, LOS CUALES PUEDEN CONTENER LIGANDOS CON ESPECIFICIDAD POR EL BLANCO PARA MEJORAR EL DIRECCIONAMIENTO PASIVO Y ACTIVO.POLYMERIC NANOPARTICLES WITH CATIONIC SURFACE POTENTIAL ARE DESCRIBED IN WHICH NEUTRAL, HYDROPHOBIC AND HYDROPHYTIC SUBSTANCES WITH PHARMACEUTICAL ACTIVITY CAN BE ENCLOSED. THE HYDROPHYLIC SUBSTANCES, AND THEREFORE, SOLUBLE IN WATER, ARE ENCAPSULATED IN THE PARTICLE THAT CONSTITUTES THE CORE BY CO-PRECIPITATION, THROUGH IONIC COMPLEXIZATION WITH A LOADED POLYMER. AS SUBSTANCES WITH PHARMACEUTICAL ACTIVITY FOR ENCAPSULATION THERAPEUTIC AGENTS AND DIAGNOSTIC AGENTS CAN BE USED. THE CATIÓNICA SURFACE OF THE PARTICLE ALLOWS TO PERFORM A STABLE ELECTROSTATIC MODIFICATION OF THE SURFACE WITH COMPOUNDS WITH PARTIALLY OPPOSED CHARGES, WHICH MAY CONTAIN SPECIFICITY LINKS BY THE WHITE TO IMPROVE THE PASSIVE AND ACTIVE ADDRESS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102007059752A DE102007059752A1 (en) | 2007-12-10 | 2007-12-10 | Functionalized solid polymer nanoparticles containing epothilones |
Publications (1)
Publication Number | Publication Date |
---|---|
PA8806901A1 true PA8806901A1 (en) | 2009-07-23 |
Family
ID=40409013
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PA20088806901A PA8806901A1 (en) | 2007-12-10 | 2008-12-09 | SOLID FUNCTIONED POLYMER NANOPARTICLES THAT INCLUDE EPOTILONES |
Country Status (7)
Country | Link |
---|---|
AR (1) | AR069638A1 (en) |
DE (1) | DE102007059752A1 (en) |
PA (1) | PA8806901A1 (en) |
PE (1) | PE20091107A1 (en) |
TW (1) | TW200932220A (en) |
UY (1) | UY31521A1 (en) |
WO (1) | WO2009074274A1 (en) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010005725A2 (en) | 2008-06-16 | 2010-01-14 | Bind Biosciences, Inc. | Therapeutic polymeric nanoparticles comprising vinca alkaloids and methods of making and using same |
JP2012501965A (en) | 2008-06-16 | 2012-01-26 | バインド バイオサイエンシズ インコーポレイテッド | Drug-loaded polymer nanoparticles and methods for producing and using the same |
US8613951B2 (en) | 2008-06-16 | 2013-12-24 | Bind Therapeutics, Inc. | Therapeutic polymeric nanoparticles with mTor inhibitors and methods of making and using same |
US8563041B2 (en) | 2008-12-12 | 2013-10-22 | Bind Therapeutics, Inc. | Therapeutic particles suitable for parenteral administration and methods of making and using same |
WO2010075072A2 (en) | 2008-12-15 | 2010-07-01 | Bind Biosciences | Long circulating nanoparticles for sustained release of therapeutic agents |
CN102361636A (en) * | 2009-03-03 | 2012-02-22 | 公立大学法人横浜市立大学 | Amino acid-conjugated cyanoacrylate polymer particles |
EP2509634B1 (en) | 2009-12-11 | 2019-03-06 | Pfizer Inc | Stable formulations for lyophilizing therapeutic particles |
EA201290498A1 (en) * | 2009-12-15 | 2013-01-30 | Байнд Байосайенсиз, Инк. | THERAPEUTIC POLYMER NANOPARTICLES, INCLUDING EPOTILON, AND METHODS FOR THEIR PREPARATION AND APPLICATION |
JP5965844B2 (en) | 2009-12-15 | 2016-08-10 | バインド セラピューティックス インコーポレイテッド | Therapeutic polymer nanoparticle compositions having high glass transition temperature or high molecular weight copolymers |
AU2011255647A1 (en) | 2010-05-18 | 2012-11-15 | Cerulean Pharma Inc. | Compositions and methods for treatment of autoimmune and other diseases |
US9610367B2 (en) | 2010-08-24 | 2017-04-04 | Canon Kabushiki Kaisha | Particle and contrast agent having the particle |
ES2732377T3 (en) | 2012-09-17 | 2019-11-22 | Pfizer | Therapeutic nanoparticle preparation procedure |
JP6564369B2 (en) | 2013-12-09 | 2019-08-21 | デュレクト コーポレイション | Pharmaceutically active agent conjugates, polymer conjugates, and compositions and methods involving them |
BR112016021130A2 (en) | 2014-03-14 | 2017-08-15 | Pfizer | THERAPEUTIC NANOPARTICLES, PHARMACEUTICAL COMPOSITION INCLUDING THE SAID NANOPARTICLES, PROCESS FOR THE PREPARATION AND USE THEREOF |
WO2015181346A1 (en) * | 2014-05-30 | 2015-12-03 | AbbVie Deutschland GmbH & Co. KG | Highly drug-loaded poly(alkyl 2-cyanoacrylate) nanocapsules |
DE102017100317A1 (en) | 2017-01-10 | 2018-07-12 | Friedrich-Schiller-Universität Jena | Nanostructured carrier system for gene delivery |
WO2024041984A1 (en) * | 2022-08-22 | 2024-02-29 | Agfa-Gevaert Nv | Near infrared and red light absorbing composite resin particles |
Family Cites Families (48)
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US252028A (en) | 1882-01-10 | Alonzo s | ||
US262030A (en) | 1882-08-01 | Wash-stand | ||
US258286A (en) | 1882-05-23 | Fruit-drier | ||
US4774339A (en) | 1987-08-10 | 1988-09-27 | Molecular Probes, Inc. | Chemically reactive dipyrrometheneboron difluoride dyes |
CA2032169A1 (en) * | 1989-05-04 | 1990-11-05 | Steven Kornguth | Method for localization and treatment of tumors and complexes therefor |
US5366860A (en) | 1989-09-29 | 1994-11-22 | Applied Biosystems, Inc. | Spectrally resolvable rhodamine dyes for nucleic acid sequence determination |
US5274113A (en) | 1991-11-01 | 1993-12-28 | Molecular Probes, Inc. | Long wavelength chemically reactive dipyrrometheneboron difluoride dyes and conjugates |
US5433896A (en) | 1994-05-20 | 1995-07-18 | Molecular Probes, Inc. | Dibenzopyrrometheneboron difluoride dyes |
US5227487A (en) | 1990-04-16 | 1993-07-13 | Molecular Probes, Inc. | Certain tricyclic and pentacyclic-hetero nitrogen rhodol dyes |
US5248782A (en) | 1990-12-18 | 1993-09-28 | Molecular Probes, Inc. | Long wavelength heteroaryl-substituted dipyrrometheneboron difluoride dyes |
US5187288A (en) | 1991-05-22 | 1993-02-16 | Molecular Probes, Inc. | Ethenyl-substituted dipyrrometheneboron difluoride dyes and their synthesis |
DE4138042C2 (en) | 1991-11-19 | 1993-10-14 | Biotechnolog Forschung Gmbh | Epothilones, their production processes and agents containing these compounds |
FR2684103B1 (en) | 1991-11-22 | 1994-09-02 | Centre Nat Rech Scient | NOVEL COMPOUNDS WITH GUANIDIC STRUCTURE AND PHARMACEUTICAL COMPOSITION CONTAINING THEM. |
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WO1997019086A1 (en) | 1995-11-17 | 1997-05-29 | GESELLSCHAFT FüR BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF) | Epothilone derivatives, preparation and use |
US6204388B1 (en) | 1996-12-03 | 2001-03-20 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
US6380394B1 (en) | 1996-12-13 | 2002-04-30 | The Scripps Research Institute | Epothilone analogs |
US6441186B1 (en) | 1996-12-13 | 2002-08-27 | The Scripps Research Institute | Epothilone analogs |
DE19728914A1 (en) | 1997-07-07 | 1999-01-14 | Basf Ag | Metallic colored polyamides |
US6605599B1 (en) | 1997-07-08 | 2003-08-12 | Bristol-Myers Squibb Company | Epothilone derivatives |
AU9340998A (en) | 1997-08-09 | 1999-03-01 | Schering Aktiengesellschaft | New epothilone derivatives, method for producing same and their pharmaceutical use |
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US6320045B1 (en) | 1997-12-04 | 2001-11-20 | Bristol-Myers Squibb Company | Process for the reduction of oxiranyl epothilones to olefinic epothilones |
FR2775187B1 (en) | 1998-02-25 | 2003-02-21 | Novartis Ag | USE OF EPOTHILONE B FOR THE MANUFACTURE OF AN ANTIPROLIFERATIVE PHARMACEUTICAL PREPARATION AND A COMPOSITION COMPRISING EPOTHILONE B AS AN IN VIVO ANTIPROLIFERATIVE AGENT |
DE19820599A1 (en) | 1998-05-08 | 1999-11-11 | Biotechnolog Forschung Gmbh | New epothilone derivatives useful as pharmaceuticals and in plant protection |
WO1999067253A2 (en) | 1998-06-22 | 1999-12-29 | Novartis Ag | Desmethyl epothilones |
SE517641C2 (en) | 1998-07-02 | 2002-07-02 | Sca Hygiene Prod Ab | Process for making a material layer with barrier tabs and a surface layer with such barrier tabs |
JP2000095758A (en) | 1998-09-18 | 2000-04-04 | Schering Ag | Near-infrared, fluorescent contrast medium, and its production |
ATE248175T1 (en) | 1998-12-22 | 2003-09-15 | Novartis Pharma Gmbh | EPOTHILONE DERIVATIVES AND THEIR USE AS ANTI-TUMOR AGENTS |
DE19908760A1 (en) | 1999-02-18 | 2000-08-24 | Schering Ag | New, chemically and metabolically stable epothilon derivatives having modified macrocyclic ring, useful e.g. for treating malignant tumors or chronic inflammatory disease, are cell division regulators |
DE19908763A1 (en) | 1999-02-18 | 2000-08-24 | Schering Ag | New, chemically and metabolically stable benzo-fused epothilon derivatives, useful e.g. for treating malignant tumors or chronic inflammatory disease, are cell division regulators |
IL144519A0 (en) | 1999-02-18 | 2002-05-23 | Schering Ag | 16-halogen-epothilone derivatives, method for producing them and their pharmaceutical use |
DE19907588A1 (en) | 1999-02-22 | 2000-08-24 | Biotechnolog Forschung Gmbh | New C-21 modified epothilone derivatives useful for treating e.g. cancer and other proliferative diseases and inhibiting angiogenesis and inducing apoptosis |
CA2368658A1 (en) | 1999-03-29 | 2000-10-05 | Soong-Hoon Kim | A process for the preparation of aziridinyl epothilones from oxiranyl epothilones |
PE20010116A1 (en) | 1999-04-30 | 2001-02-15 | Schering Ag | 6-ALKENYL-, 6-ALKINYL- AND 6-EPOXY-EPOTILONE DERIVATIVES, PROCEDURES FOR THEIR PREPARATION |
AU7662600A (en) | 1999-10-08 | 2001-04-23 | Novartis Ag | 13-alkyl epothilone derivatives |
WO2001064650A2 (en) | 2000-03-01 | 2001-09-07 | Sloan-Kettering Institute For Cancer Research Center | Synthesis of epothilones, intermediates thereto and analogues thereof |
US6518421B1 (en) | 2000-03-20 | 2003-02-11 | Bristol-Myers Squibb Company | Process for the preparation of epothilone analogs |
US6593115B2 (en) | 2000-03-24 | 2003-07-15 | Bristol-Myers Squibb Co. | Preparation of epothilone intermediates |
DE10020517A1 (en) | 2000-04-19 | 2001-10-25 | Schering Ag | New 13-halo or cyano-epothilone derivatives, are phase-specific cell division regulators useful for treating malignant tumors, angiogenesis or inflammatory disease |
US20020045609A1 (en) | 2000-05-26 | 2002-04-18 | Gary Ashley | Epothilone derivatives and methods for making and using the same |
WO2002008440A2 (en) | 2000-07-25 | 2002-01-31 | Kosan Biosciences, Inc. | Fermentation process for epothilones |
UA75365C2 (en) | 2000-08-16 | 2006-04-17 | Bristol Myers Squibb Co | Epothilone analog polymorph modifications, a method for obtaining thereof (variants), a pharmaceutical composition based thereon |
US6989450B2 (en) | 2000-10-13 | 2006-01-24 | The University Of Mississippi | Synthesis of epothilones and related analogs |
DE50111753D1 (en) | 2000-10-16 | 2007-02-08 | R & D Biopharmaceuticals | EPOTHILON SYNTHETIC COMPONENTS I: UNSYMMETRICALLY SUBSTITUTED ACYLOINS AND ACYLOOD DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, AND THEIR USE FOR THE PREPARATION OF EPOTHILONES AND EPOTHILONE DERIVATIVES |
AU2002338336A1 (en) | 2001-04-03 | 2002-10-21 | Kosan Biosciences, Inc. | Epothilone derivatives and methods for making and using the same |
DE102005041860A1 (en) * | 2005-09-02 | 2007-03-08 | Schering Ag | Nano-particle embedded- and charged-complex, useful for the production of a pharmaceutical composition, comprises two complex partners, where the complex partner is an embedded anionic and a cationic active substance |
US20100196280A1 (en) * | 2006-06-08 | 2010-08-05 | Katrin Claudia Fischer | Functionalized solid polymer nanoparticles for diagnostic and therapeutic applications |
-
2007
- 2007-12-10 DE DE102007059752A patent/DE102007059752A1/en not_active Withdrawn
-
2008
- 2008-12-06 WO PCT/EP2008/010371 patent/WO2009074274A1/en active Application Filing
- 2008-12-09 PE PE2008002025A patent/PE20091107A1/en not_active Application Discontinuation
- 2008-12-09 UY UY31521A patent/UY31521A1/en not_active Application Discontinuation
- 2008-12-09 TW TW097147937A patent/TW200932220A/en unknown
- 2008-12-09 PA PA20088806901A patent/PA8806901A1/en unknown
- 2008-12-10 AR ARP080105366A patent/AR069638A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
UY31521A1 (en) | 2009-08-03 |
TW200932220A (en) | 2009-08-01 |
WO2009074274A1 (en) | 2009-06-18 |
PE20091107A1 (en) | 2009-08-29 |
AR069638A1 (en) | 2010-02-10 |
DE102007059752A1 (en) | 2009-06-18 |
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