PA8629701A1 - Inhibidores de la dipeptidil peptidasa iv - Google Patents
Inhibidores de la dipeptidil peptidasa ivInfo
- Publication number
- PA8629701A1 PA8629701A1 PA20058629701A PA8629701A PA8629701A1 PA 8629701 A1 PA8629701 A1 PA 8629701A1 PA 20058629701 A PA20058629701 A PA 20058629701A PA 8629701 A PA8629701 A PA 8629701A PA 8629701 A1 PA8629701 A1 PA 8629701A1
- Authority
- PA
- Panama
- Prior art keywords
- toxyces
- syndosis
- syndrome
- diabetic
- diabetes
- Prior art date
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- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A61P9/00—Drugs for disorders of the cardiovascular system
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- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
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- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D207/26—2-Pyrrolidones
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- C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D207/28—2-Pyrrolidone-5- carboxylic acids; Functional derivatives thereof, e.g. esters, nitriles
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- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/32—One oxygen atom
- C07D233/38—One oxygen atom with acyl radicals or hetero atoms directly attached to ring nitrogen atoms
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- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
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- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
LA INVENCION PROPORCIONA COMPUESTOS DE FORMULA(I): O PROFAMARCO DE LOS MISMOS O SALES FARMACEUTICAMENTE ACEPTABLES DE DICHOS COMPUESTOS O PROFARMACOS O SOLVATOS DE DICHOS COMPUESTOS, PROFARMACOS O SALES, EN LOS QUE A, N, X Y R1 SON COMO SE DEFINIO EN LA PRESENTE MEMORIA; COMPOSICIONES FARMACEUTICAS DE LOS MISMOS; Y METODOS PARA USAR LAS COMPOSICIONES FARMACEUTICAS PARA EL TRATAMIENTO DE ENFERMEDADES, INCLUYENDO DIABETES DE TIPO 2, DIABETES DE TIPO 1, TOLERANCIA A LA GLUCOSA DEBILITADA, HIPERGLUCEMIA, SINDROME METABOLICO (SINDROME X Y/O SINDROME DE RESISTENCIA A LA INSULINA), GLUCOSURIA, ACIDOSIS METABOLICA REUMATISMO ARTICULAR, CATARATAS, NEUROPATIA DIABETICA, NEFROPATIA DIABETICA, RETINOPATIA DIABETICA, CARDIOMIOPATIA DIABETICA, OBESIDAD, AFECCIONES EXACERBADAS POR: OBESIDAD, HIPERTENSION ARTERIAL, HIPERLIPIDEMIA, ATEROESCLEROSIS, OSTEOPOROSIS, OSTEOPENIA, DEBILIDAD, OSTEOLISIS, FRACTURA OSEA, SINDROME CORONARIO AGUDO, TALLA BAJA DEBIDO A DEFICIENCIA EN HORMONA DEL CRECIMIENTO, INFERTILIDAD DEBIDO A SINDROME OVARICO POLICISTICO, ANSIEDAD, DEPRESION, INSOMNIO, FATIGA CRONICA, EPILEPSIA, TRASTORNOS ALIMENTARIOS, DOLOR CRONICO, ADICCION AL ALCOHOL, ENFERMEDADES ASOCIADAS CON MOTILIDAD INTESTINAL, ULCERAS, SINDROME DEL INTESTINO IRRITABLE, SINDROME DEL INTESTINO INFLAMADO, SINDROME DEL INTESTINO CORTO; Y LA PREVENCION DE LA PROGRESION DE LA ENFERMEDAD EN DIABETES DE TIPO 2.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US56258304P | 2004-04-14 | 2004-04-14 | |
US65951805P | 2005-03-07 | 2005-03-07 |
Publications (1)
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PA8629701A1 true PA8629701A1 (es) | 2006-06-02 |
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Family Applications (1)
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PA20058629701A PA8629701A1 (es) | 2004-04-14 | 2005-04-13 | Inhibidores de la dipeptidil peptidasa iv |
Country Status (6)
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US (1) | US20050234065A1 (es) |
AR (1) | AR049881A1 (es) |
NL (1) | NL1028761C2 (es) |
PA (1) | PA8629701A1 (es) |
TW (1) | TW200538101A (es) |
WO (1) | WO2005100334A1 (es) |
Families Citing this family (23)
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TW200730494A (en) * | 2005-10-10 | 2007-08-16 | Glaxo Group Ltd | Novel compounds |
WO2007042250A1 (en) * | 2005-10-10 | 2007-04-19 | Glaxo Group Limited | Prolinamide derivatives as sodium channel modulators |
GB0526291D0 (en) | 2005-12-23 | 2006-02-01 | Prosidion Ltd | Therapeutic method |
PE20071221A1 (es) | 2006-04-11 | 2007-12-14 | Arena Pharm Inc | Agonistas del receptor gpr119 en metodos para aumentar la masa osea y para tratar la osteoporosis y otras afecciones caracterizadas por masa osea baja, y la terapia combinada relacionada a estos agonistas |
WO2009037719A1 (en) * | 2007-09-21 | 2009-03-26 | Lupin Limited | Novel compounds as dipeptidyl peptidase iv (dpp iv) inhibitors |
EP2146210A1 (en) | 2008-04-07 | 2010-01-20 | Arena Pharmaceuticals, Inc. | Methods of using A G protein-coupled receptor to identify peptide YY (PYY) secretagogues and compounds useful in the treatment of conditions modulated by PYY |
US8344160B2 (en) | 2008-10-08 | 2013-01-01 | Bristol-Myers Squibb Company | Pyrrolone melanin concentrating hormone receptor-1 antagonists |
WO2010146597A1 (en) | 2009-06-18 | 2010-12-23 | Lupin Limited | 2-amino-2- [8-(dimethyl carbamoyl)- 8-aza- bicyclo [3.2.1] oct-3-yl]-exo- ethanoyl derivatives as potent dpp-iv inhibitors |
WO2011016576A1 (en) | 2009-08-04 | 2011-02-10 | Takeda Pharmaceutical Company Limited | Alanine derivatives as inhibitors of apoptosis proteins |
CA2891122C (en) | 2012-11-14 | 2021-07-20 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
EA031804B1 (ru) | 2014-02-03 | 2019-02-28 | Вайтаи Фармасьютиклз, Инк. | Дигидропирролопиридиновые ингибиторы ror-гамма |
HUE042335T2 (hu) | 2014-10-14 | 2019-06-28 | Vitae Pharmaceuticals Inc | ROR-gamma dihidropirrolopiridin inhibitorai |
US9845308B2 (en) | 2014-11-05 | 2017-12-19 | Vitae Pharmaceuticals, Inc. | Isoindoline inhibitors of ROR-gamma |
US9663515B2 (en) | 2014-11-05 | 2017-05-30 | Vitae Pharmaceuticals, Inc. | Dihydropyrrolopyridine inhibitors of ROR-gamma |
EP3237379B1 (en) | 2014-12-23 | 2022-04-06 | Convergence Pharmaceuticals Limited | Process for preparing alpha-carboxamide pyrrolidine derivatives |
EP3331876B1 (en) | 2015-08-05 | 2020-10-07 | Vitae Pharmaceuticals, LLC | Modulators of ror-gamma |
EP3377482B1 (en) | 2015-11-20 | 2021-05-12 | Vitae Pharmaceuticals, LLC | Modulators of ror-gamma |
TW202220968A (zh) | 2016-01-29 | 2022-06-01 | 美商維它藥物有限責任公司 | ROR-γ調節劑 |
US9481674B1 (en) | 2016-06-10 | 2016-11-01 | Vitae Pharmaceuticals, Inc. | Dihydropyrrolopyridine inhibitors of ROR-gamma |
WO2019018975A1 (en) | 2017-07-24 | 2019-01-31 | Vitae Pharmaceuticals, Inc. | INHIBITORS OF ROR GAMMA |
CN115650976A (zh) | 2017-07-24 | 2023-01-31 | 生命医药有限责任公司 | RORγ的抑制剂 |
WO2019040109A1 (en) | 2017-08-21 | 2019-02-28 | Celgene Corporation | PROCESSES FOR THE PREPARATION OF (S) -TERT-BUTYL 4,5-DIAMINO-5-OXOPENTANOATE |
SG10202112966SA (en) | 2017-10-05 | 2021-12-30 | Biogen Inc | Process for preparing αlpha-carboxamide pyrrolidine derivatives |
Family Cites Families (1)
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CA2441092A1 (en) * | 2001-03-27 | 2002-10-03 | Merck & Co., Inc. | Dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes |
-
2005
- 2005-04-01 WO PCT/IB2005/000907 patent/WO2005100334A1/en active Application Filing
- 2005-04-08 US US11/102,394 patent/US20050234065A1/en not_active Abandoned
- 2005-04-12 AR ARP050101422A patent/AR049881A1/es unknown
- 2005-04-13 NL NL1028761A patent/NL1028761C2/nl not_active IP Right Cessation
- 2005-04-13 TW TW094111658A patent/TW200538101A/zh unknown
- 2005-04-13 PA PA20058629701A patent/PA8629701A1/es unknown
Also Published As
Publication number | Publication date |
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WO2005100334A1 (en) | 2005-10-27 |
NL1028761A1 (nl) | 2005-10-17 |
TW200538101A (en) | 2005-12-01 |
AR049881A1 (es) | 2006-09-13 |
NL1028761C2 (nl) | 2006-03-27 |
US20050234065A1 (en) | 2005-10-20 |
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