PA8564301A1 - COMPRESSED NELFINAVIR INCREASED DOSE AND METHOD TO MANUFACTURE IT - Google Patents
COMPRESSED NELFINAVIR INCREASED DOSE AND METHOD TO MANUFACTURE ITInfo
- Publication number
- PA8564301A1 PA8564301A1 PA20038564301A PA8564301A PA8564301A1 PA 8564301 A1 PA8564301 A1 PA 8564301A1 PA 20038564301 A PA20038564301 A PA 20038564301A PA 8564301 A PA8564301 A PA 8564301A PA 8564301 A1 PA8564301 A1 PA 8564301A1
- Authority
- PA
- Panama
- Prior art keywords
- nelfinavir
- compressed
- manufacture
- increased dose
- mixture
- Prior art date
Links
- QAGYKUNXZHXKMR-UHFFFAOYSA-N CPD000469186 Natural products CC1=C(O)C=CC=C1C(=O)NC(C(O)CN1C(CC2CCCCC2C1)C(=O)NC(C)(C)C)CSC1=CC=CC=C1 QAGYKUNXZHXKMR-UHFFFAOYSA-N 0.000 title abstract 5
- 229960000884 nelfinavir Drugs 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 4
- QAGYKUNXZHXKMR-HKWSIXNMSA-N nelfinavir Chemical compound CC1=C(O)C=CC=C1C(=O)N[C@H]([C@H](O)CN1[C@@H](C[C@@H]2CCCC[C@@H]2C1)C(=O)NC(C)(C)C)CSC1=CC=CC=C1 QAGYKUNXZHXKMR-HKWSIXNMSA-N 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 3
- 238000005469 granulation Methods 0.000 abstract 2
- 230000003179 granulation Effects 0.000 abstract 2
- -1 NELFINAVIR COMPOUND Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Glanulating (AREA)
Abstract
UN COMPRIMIDO DE NELFINAVIR DE DOSIS ELEVADA QUE TIENE UNA RELACION EN PESO DE NELFINAVIR A AGLUTINANTE DE APROXIMADAMENTE 3:1 A APROXIMADAMENTE 5:1. LOS COMPRIMIDOS DE NELFINAVIR DE DOSIS ELEVADA SE FABRICAN EN UN PROCEDIMIENTO EN EL QUE SE FORMA UNA MEZCLA GRANULADA DE UN COMPUESTO DE NELFINAVIR Y UN AGLUTINANTE, EN UN PROCEDIMIENTO DE GRANULACION, Y A CONTINUACION SE ELABORA PARA FORMAR LOS COMPRIMIDOS. EN EL PROCEDIMIENTO DE GRANULACION SE ANADE HUMEDAD Y SE APLICA ENERGIA MECANICA A LA MEZCLA, Y LA MEZCLA SE CURA SIN ADICION DE HUMEDAD O APLICACION DE ENERGIA MECANICA.A NELFINAVIR COMPRESSED OF HIGH DOSE THAT HAS A NELFINAVIR WEIGHT RELATIONSHIP TO A BINDING APPROXIMATELY 3: 1 TO APPROXIMATELY 5: 1. THE NELFINAVIR TABLETS OF ELEVATED DOSE ARE MANUFACTURED IN A PROCEDURE IN WHICH A GRANULATED MIXTURE OF A NELFINAVIR COMPOUND AND A BINDER IS FORMED, IN A GRANULATION PROCEDURE, AND BELOW IT IS PREPARED TO FORM THE COMPRESSED. IN THE GRANULATION PROCEDURE, MOISTURE IS ADDED AND MECHANICAL ENERGY IS APPLIED TO THE MIXTURE, AND THE MIXTURE IS CURE WITHOUT ADDITION OF MOISTURE OR APPLICATION OF MECHANICAL ENERGY.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35142002P | 2002-01-28 | 2002-01-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PA8564301A1 true PA8564301A1 (en) | 2003-09-05 |
Family
ID=27663002
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PA20038564301A PA8564301A1 (en) | 2002-01-28 | 2003-01-28 | COMPRESSED NELFINAVIR INCREASED DOSE AND METHOD TO MANUFACTURE IT |
Country Status (23)
| Country | Link |
|---|---|
| EP (1) | EP1469836A1 (en) |
| JP (1) | JP2005521661A (en) |
| KR (1) | KR20040079952A (en) |
| CN (1) | CN1713895A (en) |
| AR (1) | AR038236A1 (en) |
| BR (1) | BR0307190A (en) |
| CA (1) | CA2398226A1 (en) |
| GT (1) | GT200300016A (en) |
| HN (1) | HN2003000048A (en) |
| HU (1) | HUP0500512A2 (en) |
| IL (1) | IL162724A0 (en) |
| MX (1) | MXPA04007237A (en) |
| NI (1) | NI200300001A (en) |
| NO (1) | NO20043238L (en) |
| NZ (1) | NZ533283A (en) |
| PA (1) | PA8564301A1 (en) |
| PE (1) | PE20030730A1 (en) |
| PL (1) | PL373882A1 (en) |
| RU (1) | RU2004123206A (en) |
| SV (1) | SV2004001467A (en) |
| TW (1) | TW200302111A (en) |
| WO (1) | WO2003063837A1 (en) |
| ZA (1) | ZA200404367B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008053276A1 (en) * | 2006-10-30 | 2008-05-08 | Collette Nv | Transition piece for the transfer of powder or granular material from a discharge opening to a conveying line and method of transferring powder or granular material |
| KR20100057885A (en) * | 2007-09-03 | 2010-06-01 | 알카텔-루센트 유에스에이 인코포레이티드 | Method and system for checking automatically connectivity status of an ip link on ip network |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6499984B1 (en) * | 2000-05-22 | 2002-12-31 | Warner-Lambert Company | Continuous production of pharmaceutical granulation |
| CZ20033211A3 (en) * | 2001-05-03 | 2004-09-15 | F. Hoffmann-La Roche Ag | Pharmaceutical dosage form of amorphous nelfinavir mesylate |
-
2002
- 2002-08-15 CA CA002398226A patent/CA2398226A1/en not_active Abandoned
-
2003
- 2003-01-07 NI NI200300001A patent/NI200300001A/en unknown
- 2003-01-16 BR BR0307190-1A patent/BR0307190A/en not_active IP Right Cessation
- 2003-01-16 IL IL16272403A patent/IL162724A0/en unknown
- 2003-01-16 PL PL03373882A patent/PL373882A1/en not_active Application Discontinuation
- 2003-01-16 KR KR10-2004-7011562A patent/KR20040079952A/en not_active Ceased
- 2003-01-16 NZ NZ533283A patent/NZ533283A/en unknown
- 2003-01-16 HU HU0500512A patent/HUP0500512A2/en unknown
- 2003-01-16 JP JP2003563531A patent/JP2005521661A/en active Pending
- 2003-01-16 EP EP03700070A patent/EP1469836A1/en not_active Withdrawn
- 2003-01-16 CN CNA038028360A patent/CN1713895A/en active Pending
- 2003-01-16 MX MXPA04007237A patent/MXPA04007237A/en unknown
- 2003-01-16 RU RU2004123206/15A patent/RU2004123206A/en not_active Application Discontinuation
- 2003-01-16 WO PCT/IB2003/000117 patent/WO2003063837A1/en not_active Ceased
- 2003-01-24 PE PE2003000074A patent/PE20030730A1/en not_active Application Discontinuation
- 2003-01-27 SV SV2003001467A patent/SV2004001467A/en not_active Application Discontinuation
- 2003-01-27 AR ARP030100228A patent/AR038236A1/en unknown
- 2003-01-27 HN HN2003000048A patent/HN2003000048A/en unknown
- 2003-01-27 TW TW092101739A patent/TW200302111A/en unknown
- 2003-01-28 PA PA20038564301A patent/PA8564301A1/en unknown
- 2003-01-28 GT GT200300016A patent/GT200300016A/en unknown
-
2004
- 2004-06-03 ZA ZA200404367A patent/ZA200404367B/en unknown
- 2004-08-02 NO NO20043238A patent/NO20043238L/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GT200300016A (en) | 2003-09-11 |
| KR20040079952A (en) | 2004-09-16 |
| CN1713895A (en) | 2005-12-28 |
| CA2398226A1 (en) | 2003-07-28 |
| SV2004001467A (en) | 2004-05-07 |
| HN2003000048A (en) | 2003-10-28 |
| WO2003063837A1 (en) | 2003-08-07 |
| TW200302111A (en) | 2003-08-01 |
| NI200300001A (en) | 2004-12-21 |
| NO20043238L (en) | 2004-08-02 |
| RU2004123206A (en) | 2005-04-20 |
| MXPA04007237A (en) | 2004-10-29 |
| PE20030730A1 (en) | 2003-08-28 |
| JP2005521661A (en) | 2005-07-21 |
| NZ533283A (en) | 2006-12-22 |
| IL162724A0 (en) | 2005-11-20 |
| ZA200404367B (en) | 2006-05-31 |
| BR0307190A (en) | 2004-11-03 |
| EP1469836A1 (en) | 2004-10-27 |
| PL373882A1 (en) | 2005-09-19 |
| HUP0500512A2 (en) | 2005-09-28 |
| AR038236A1 (en) | 2005-01-05 |
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