HUP0500512A2 - Increased-dosage nelfinavir tablet and method of making same - Google Patents
Increased-dosage nelfinavir tablet and method of making sameInfo
- Publication number
- HUP0500512A2 HUP0500512A2 HU0500512A HUP0500512A HUP0500512A2 HU P0500512 A2 HUP0500512 A2 HU P0500512A2 HU 0500512 A HU0500512 A HU 0500512A HU P0500512 A HUP0500512 A HU P0500512A HU P0500512 A2 HUP0500512 A2 HU P0500512A2
- Authority
- HU
- Hungary
- Prior art keywords
- tablet
- increased
- nelfinavir
- making same
- mixture
- Prior art date
Links
- QAGYKUNXZHXKMR-UHFFFAOYSA-N CPD000469186 Natural products CC1=C(O)C=CC=C1C(=O)NC(C(O)CN1C(CC2CCCCC2C1)C(=O)NC(C)(C)C)CSC1=CC=CC=C1 QAGYKUNXZHXKMR-UHFFFAOYSA-N 0.000 title abstract 5
- 229960000884 nelfinavir Drugs 0.000 title abstract 5
- QAGYKUNXZHXKMR-HKWSIXNMSA-N nelfinavir Chemical compound CC1=C(O)C=CC=C1C(=O)N[C@H]([C@H](O)CN1[C@@H](C[C@@H]2CCCC[C@@H]2C1)C(=O)NC(C)(C)C)CSC1=CC=CC=C1 QAGYKUNXZHXKMR-HKWSIXNMSA-N 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 abstract 3
- 239000011230 binding agent Substances 0.000 abstract 2
- 238000005469 granulation Methods 0.000 abstract 2
- 230000003179 granulation Effects 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- -1 nelfinavir compound Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Glanulating (AREA)
Abstract
A találmány tárgya megnövelt dózisú nelfinavir tabletta, és eljárás atabletta előállítására. Egy nagy dózisú nelfinavir tablettában anelfinavir/kötőanyag tömegaránya kb. 3:1-5:1. A nagy dózisú nelfinavirtablettákat úgy állítják elő, hogy egy nelfinavir vegyületből éskötőanyagból álló granulált elegyet képeznek egy granulálásifolyamatban, majd tablettákká alakítják. A granulálási folyamatbannedvességet adnak hozzá, és mechanikus energiát alkalmaznak azelegyre, és az elegyet nedvesség hozzáadása nélkül vagy mechanikusenergia alkalmazása nélkül szárítják.The subject of the invention is an increased dose nelfinavir tablet and a method for producing a tablet. In a high-dose nelfinavir tablet, the weight ratio of anelfinavir/binder is approx. 3:1-5:1. High-dose nelfinavir tablets are produced by forming a granulated mixture of a nelfinavir compound and a binder in a granulation process and then forming them into tablets. In the granulation process, moisture is added and mechanical energy is applied to the mixture, and the mixture is dried without adding moisture or applying mechanical energy.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35142002P | 2002-01-28 | 2002-01-28 | |
| PCT/IB2003/000117 WO2003063837A1 (en) | 2002-01-28 | 2003-01-16 | Increased-dosage nelfinavir tablet and method of making same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUP0500512A2 true HUP0500512A2 (en) | 2005-09-28 |
Family
ID=27663002
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0500512A HUP0500512A2 (en) | 2002-01-28 | 2003-01-16 | Increased-dosage nelfinavir tablet and method of making same |
Country Status (23)
| Country | Link |
|---|---|
| EP (1) | EP1469836A1 (en) |
| JP (1) | JP2005521661A (en) |
| KR (1) | KR20040079952A (en) |
| CN (1) | CN1713895A (en) |
| AR (1) | AR038236A1 (en) |
| BR (1) | BR0307190A (en) |
| CA (1) | CA2398226A1 (en) |
| GT (1) | GT200300016A (en) |
| HN (1) | HN2003000048A (en) |
| HU (1) | HUP0500512A2 (en) |
| IL (1) | IL162724A0 (en) |
| MX (1) | MXPA04007237A (en) |
| NI (1) | NI200300001A (en) |
| NO (1) | NO20043238L (en) |
| NZ (1) | NZ533283A (en) |
| PA (1) | PA8564301A1 (en) |
| PE (1) | PE20030730A1 (en) |
| PL (1) | PL373882A1 (en) |
| RU (1) | RU2004123206A (en) |
| SV (1) | SV2004001467A (en) |
| TW (1) | TW200302111A (en) |
| WO (1) | WO2003063837A1 (en) |
| ZA (1) | ZA200404367B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008053276A1 (en) * | 2006-10-30 | 2008-05-08 | Collette Nv | Transition piece for the transfer of powder or granular material from a discharge opening to a conveying line and method of transferring powder or granular material |
| JP2010538551A (en) * | 2007-09-03 | 2010-12-09 | アルカテル−ルーセント ユーエスエー インコーポレーテッド | Method and system for automatically confirming connectivity status of an IP link on an IP network |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6499984B1 (en) * | 2000-05-22 | 2002-12-31 | Warner-Lambert Company | Continuous production of pharmaceutical granulation |
| JP4101661B2 (en) * | 2001-05-03 | 2008-06-18 | エフ．ホフマン−ラ ロシュ アーゲー | Pharmaceutical form of amorphous nelfinavir mesylate |
-
2002
- 2002-08-15 CA CA002398226A patent/CA2398226A1/en not_active Abandoned
-
2003
- 2003-01-07 NI NI200300001A patent/NI200300001A/en unknown
- 2003-01-16 PL PL03373882A patent/PL373882A1/en not_active Application Discontinuation
- 2003-01-16 JP JP2003563531A patent/JP2005521661A/en active Pending
- 2003-01-16 CN CNA038028360A patent/CN1713895A/en active Pending
- 2003-01-16 RU RU2004123206/15A patent/RU2004123206A/en not_active Application Discontinuation
- 2003-01-16 IL IL16272403A patent/IL162724A0/en unknown
- 2003-01-16 HU HU0500512A patent/HUP0500512A2/en unknown
- 2003-01-16 NZ NZ533283A patent/NZ533283A/en unknown
- 2003-01-16 EP EP03700070A patent/EP1469836A1/en not_active Withdrawn
- 2003-01-16 KR KR10-2004-7011562A patent/KR20040079952A/en not_active Application Discontinuation
- 2003-01-16 WO PCT/IB2003/000117 patent/WO2003063837A1/en not_active Application Discontinuation
- 2003-01-16 BR BR0307190-1A patent/BR0307190A/en not_active IP Right Cessation
- 2003-01-16 MX MXPA04007237A patent/MXPA04007237A/en unknown
- 2003-01-24 PE PE2003000074A patent/PE20030730A1/en not_active Application Discontinuation
- 2003-01-27 AR ARP030100228A patent/AR038236A1/en unknown
- 2003-01-27 HN HN2003000048A patent/HN2003000048A/en unknown
- 2003-01-27 SV SV2003001467A patent/SV2004001467A/en not_active Application Discontinuation
- 2003-01-27 TW TW092101739A patent/TW200302111A/en unknown
- 2003-01-28 PA PA20038564301A patent/PA8564301A1/en unknown
- 2003-01-28 GT GT200300016A patent/GT200300016A/en unknown
-
2004
- 2004-06-03 ZA ZA200404367A patent/ZA200404367B/en unknown
- 2004-08-02 NO NO20043238A patent/NO20043238L/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003063837A1 (en) | 2003-08-07 |
| MXPA04007237A (en) | 2004-10-29 |
| KR20040079952A (en) | 2004-09-16 |
| NI200300001A (en) | 2004-12-21 |
| CN1713895A (en) | 2005-12-28 |
| HN2003000048A (en) | 2003-10-28 |
| CA2398226A1 (en) | 2003-07-28 |
| GT200300016A (en) | 2003-09-11 |
| JP2005521661A (en) | 2005-07-21 |
| PL373882A1 (en) | 2005-09-19 |
| NZ533283A (en) | 2006-12-22 |
| RU2004123206A (en) | 2005-04-20 |
| NO20043238L (en) | 2004-08-02 |
| IL162724A0 (en) | 2005-11-20 |
| ZA200404367B (en) | 2006-05-31 |
| AR038236A1 (en) | 2005-01-05 |
| PA8564301A1 (en) | 2003-09-05 |
| SV2004001467A (en) | 2004-05-07 |
| BR0307190A (en) | 2004-11-03 |
| EP1469836A1 (en) | 2004-10-27 |
| PE20030730A1 (en) | 2003-08-28 |
| TW200302111A (en) | 2003-08-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD9A | Lapse of provisional protection due to non-payment of fees |