OA20402A - A stable insecticide composition. - Google Patents

A stable insecticide composition. Download PDF

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OA20402A
OA20402A OA1202100508 OA20402A OA 20402 A OA20402 A OA 20402A OA 1202100508 OA1202100508 OA 1202100508 OA 20402 A OA20402 A OA 20402A
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insecticide composition
agrochemical active
disintegration system
polymer matrix
composition
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OA1202100508
Inventor
Satish Ekanath Bhoge
Sanjay SARAPH
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Upl Limited
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Publication of OA20402A publication Critical patent/OA20402A/en

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Abstract

The present invention is related to a stable insecticide composition comprising: at least one agrochemical active ingredient. and a disintegration system. The present invention also provides process for preparation, use and method of controlling pests using said insecticidal composition.

Description

A STABLE INSECTICIDE COMPOSITION
FIELD OF THE INVENTION
The présent invention relates to a stable agrochemical composition. More particularly, the présent invention relates to a stable insecticide composition with good stability and dispersibility. The stable insecticide composition of the présent invention is usefol for the protection of crops.
BACKGROUND OF THE INVENTION
Many agrochemicals are currently supplied in the form of solid formulations such as powder, granular and wettable powder. Granular formulations offer varions advantages, including (1) a higher apparent spécifie gravity than wettable powders or water-soluble products with less bulkiness, (2) no airbome scattering of fine powders when suspended in water to préparé spray liquids, meaning there is no danger for operators like absorbing Chemical agents, and (3) easier weighing of the actives.
Granular products, more specifically, the Water Dispersible Granules (WDGs) are a solid, 15 non-dusty formulations which disperses or dissolves quickly when added to water in the spray tank to give a fine particle suspension. They provide a system for delivering solid active ingrédients to a target organism. They allow to produce highly-concentrated formulations which are wettable and easily disintegrated on contact with water. WDGs are important delivery vehicles for active agrochemicals because, unlike émulsion 2Q concentrâtes, they are solvent-free, do not hâve dusting problems like wettable powders (WP’s), and can be transported more economically than suspension concentrâtes (SC’s). Also, packaging material used for WDG’s is biodégradable whilst it is not the case with WP’s and SC’s.
When agrochemicals hâve relatively similar water solubility profile, préparation, storage 25 and shipping m a commercially acceptable form can be relatively easier. However, many agrochemicals having diverse solubility profile are required to be combined in a single composition based on desired biological effect. Such agrochemicals when combined together to form WDG, disintegration of such WDG becomes the major concem which is to be addressed.
In an agrochemical application, a wide variety of water insoluble actives are delivered in aqueous suspension. Water insoluble materials which may advantageously be used in WDG formulations include insecticides, herbicides, fiingicides, biocides, molluscicides, algaicides, plant growth regulators, anthelmintics, rodenticides, nematocides, acaricides, amoebicides, protozoacides, crop safeners and adjuvants. A wide variety of other insoluble materials are used in agricultural applications including fillers and carriers, for example but not limited to, naturel and synthetic silicates and silicate minerais, minerai oxides and hydroxides and naturel and synthetically derived organic materials. Such materials may be added as porous carriers, as moisture inhibition agents, to aid binding or agglomération properties of a formulation or simply to fill a formulation to a convenient weight. Examples of such fillers may include naturel silicates such as diatomaceous earth, synthetic precipitated silicas, clays such as kaolin, attapulgites and bentonites, zeolites, titanium dioxide, iron oxides and hydroxides, aluminium oxides and hydroxides, or organic materials such as bagasse, charcoal, or synthetic organic polymers.
Disintegration is frequently a prerequisite for the efficient dispersion of WDGs in water and also an important index for evaluating the performance of WDGs. Although WDG formulations are optimized to improve disintegration properties but there hâve been limited research on the factors influencing the disintegration performance of WDGs, especially in case of hydrophobie agrochemical active ingrédients. It is known that the WDGs with weak bonding proved to facilitate rapid disintegration and dispersion. Also, another factor influencing disintegration is the porosity and the package rate of the surfactant on the pesticide particles surface.
There is still no comprehensive and systematic theory for the WDG disintegration mechanism, and researchers mainly dépend on their expérience to improve the disintegration property, which restricts the development of a high-perfbrmance WDG pesticide. Water wetting the surface and difïusing to the inner space of WDGs hâve been identified as steps necessary in any disintegration process, so an appropriate porosity is essential for WDGs to achieve sufficient disintegration.
Various disintegrating agents are known in the art which are used in water dispersible granules. However, there is a need for new and improved disintegration System which improves the stability of WDG formulations and provide instantaneous or fast release of active ingrédients in the agrochemical formulation when intended to be used at desired site of application.
OBJECTIVES OF THE INVENTION
Accordingly, it is a primary object of the présent invention to provide a stable insecticide 10 composition.
Another object ofthe présent invention is to provide a stable insecticide composition in the form of water dispersible granules.
Another objective of the invention is to provide an insecticide composition with good stability and dispersibility comprising insecticidally effective amount of an agrochemical 15 active ingrédient and a disintegration System.
Yet another object ofthe présent invention is to provide a process for preparing a stable insecticide composition.
Yet another object ofthe présent invention to provide a method of controlling insects by using said stable insecticide composition.
SUMMARY OF THE INVENTION
In an aspect the présent invention provides a stable insecticide composition comprising: at least one agrochemical active ingrédient, and a disintegration System, wherein said disintegration System comprises of a polymer matrix and an inorganic sait.
In another aspect the présent invention provides a stable insecticide composition comprising:
at least one agrochemical active ingrédient selected from the group comprising of hydrophobie agrochemical active ingrédients and hydrophilic agrochemical active ingrédients, and a disintegration System, wherein said disintegration System comprises of a polymer matrix and an inorganic sait.
In another aspect, the stable insecticide composition comprising: at least one hydrophilic agrochemical active ingrédient, □ at least one hydrophobie agrochemical active ingrédient, and a disintegration System, wherein said disintegration System comprises of a polymer matrix and an inorganic sait.
In another aspect, the stable insecticide composition comprising: at least one hydrophilic agrochemical active ingrédients selected from the group comprising of pyridine organic compound and organophosphorous compound, atleast one hydrophobie agrochemical active ingrédient selected from the group comprising of phenyl pyrazole compound, diamide, triazine, pyrethroids, oxadiazine and thiourea class of compounds; and a disintegration System, wherein disintegration System comprises of a polymer matrix and an inorganic sait in an effective ratio.
In another aspect, there is provided water dispersible granular formulation comprising: at least one hydrophilic agrochemical active ingrédients selected from the group comprising of pyridine organic compound and organophosphorous compound;
atleast one hydrophobie agrochemical active ingrédient selected from the group comprising of phenyl pyrazole compound, diamide, triazine, pyrethroids, oxadiazine and thiourea class of compounds; and a disintegration System, wherein disintegration System comprises of a polymer matrix and an inorganic sait in an effective ratio.
In accordance with the above objectives, a process for préparation of stable insecticide composition said process comprising steps of:
i) adding agrochemically active ingrédient, a polymer matrix and optionally other auxiliary ingrédients and blending it to obtain blend;
ii) grinding the blend to obtain grounded mix of desired particle size;
iiijblending the grounded mix to obtain homogeneous mixture;
ivjpreparing dough from the homogeneous mixture and perform granulation,
v) drying the granules to obtain the finished composition.
Typically, the blend in step ii) is subjected to grinding to obtain grounded mix of desired particle size preferably D50 below 5 microns and D90 below 10 microns and DI00 below 30 microns.
In accordance with the above objective, the présent invention provides use of stable insecticide composition according to the présent invention as a pesticide for controlling insects.
In accordance with the above objectives, the présent invention provides a method of controlling unwanted pests especially insects said method comprising, applying an effective amount of stable insecticide compositions comprising;
at least one agrochemical active ingrédient, and a disintegration system, wherein said disintegration System comprises of a polymer matrix and an inorganic sait to the pests orto their locus.
In accordance with the above objectives, a kit comprising said stable insecticide composition according to the présent invention.
Additional features and advantages of the présent invention will be apparent from the detailed description that follows, which illustrâtes by way of example, the most preferred features of the présent invention which are not to be construed as limiting the scope of the invention described herein.
DETAILED DESCRIPTION OF THE INVENTION
The présent invention relates to solid formulations of pesticidally effective amount of active ingrédient with spécifie disintegration System to prevent dégradation of active compounds. Surprisingly, inventors of the présent invention found that disintegration System in accordance with the présent invention that is a combination of a polymer matrix 1 q and an inorganic sait work dramatically better, and sometimes even synergistically, to improve disintegration profile of water dispersible granules than either component alone. The polymer matrix and inorganic sait combination intensely enhance the disintegration profile of compositions of hydrophilic agrochemical active ingrédients with one or more agrochemical active ingrédient.
Ί 5 Inventors of the invention found that the polymer matrix influence the disintegration profile of active ingrédient and its release in the water to form suspension. Polymer matrix absorbs water through diffusion and holds it in a more controlled manner. This makes water available to disintegrate active ingrédients. Similarly, inorganic salts facilitate pore formation in the composition during drying procedure of water dispersible granules and 2Q create channels that facilitate passage of water in the granule to easily disperse in water to form suspension for end-use.
Therefore, présent invention relates to a stable insecticide composition comprising: at least one agrochemical active ingrédient, and a disintegration system, wherein said disintegration System comprises of a polymer matrix and an inorganic sait.
In an embodiment, the agrochemical active ingrédient is selected from the group of hydrophobie agrochemical active ingrédients and hydrophilic agrochemical active ingrédients or combinations thereof.
In an embodiment, the hydrophobie agrochemical active ingrédient is selected from the group comprising of phenyl pyrazole compound, diamide, triazine, pyrethroids, oxadiazine and thiourea class of compounds.
In an embodiment the hydrophilic agrochemical active ingrédient is selected from the group comprising of pyridine organic compounds, organophosphorous compounds, neonicotinoids, dithiocarbamates, phthalimides, triazines, their dérivatives and salis thereof.
In an embodiment the hydrophilic agrochemical active ingrédient is selected from the group comprising of pyridine organic compounds and organophosphorous compounds.
Examples of hydrophilic agrochemical active ingrédient include but not limited to, flonicamid, glufosinate and its salts, glyphosate and its salts , acephate, acifluorfen, bispyribac sodium, pyrazosulfuron ethyl, 2,4-D sodium sait, pymetrozine, emamectinbenzoate acetamiprid, imidacloprid, thiamethoxam spinosad captafol, captan zineb, ziram fentin acetate fentin hydroxide, captafol, captan zineb, ziram ferbam folpet, fosetyl-
Ί5 aluminium, fosetyl-sodium copper préparations, such as: copper hydroxide, copper naphthenate, copper oxychloride, copper sulphate, copper oxide, oxine-copper and Bordeaux mixture, mancopper, maneozeb, maneb, propineb and salts thereof.
In preferred embodiment of the présent invention, hydrophilic agrochemical active ingrédient is selected from the group of flonicamid, glufosinate sait, glyphosate salts, 20 pymetrozine, acephate and captan.
According to the preferred embodiment of the présent invention, the hydrophilic agrochemical active ingrédient is flonicamid.
According to an embodiment of the présent invention, hydrophilic agrochemical active ingrédient is glufosinate, its salts and dérivative thereof.
According to an embodiment of the présent invention, hydrophilic agrochemical active ingrédient is pymetrozine.
According to an embodiment of the présent invention, hydrophilic agrochemical active ingrédient is acephate.
In an embodiment, the présent invention provides a stable insecticide composition comprising from about 0.1% w/w to about 90% w/w and preferably from about 1% w/w to about 80% w/w hydrophilic agrochemical active ingrédient of the total weight of the stable agrochemical composition.
In a preferred embodiment of the présent invention, the stable insecticide composition comprises from about 5% w/w to about 80% w/w hydrophilic agrochemical active ingrédient of the total weight of the stable agrochemical composition.
According to an embodiment of the présent invention, the stable insecticide compositions comprises of hydrophobie agrochemical active ingrédients.
According to an embodiment of the présent invention, the stable insecticide compositions comprises of hydrophobie agrochemical active ingrédients selected from group comprising of phenyl pyrazole compound, diamide, triazinone, pyrethroids, oxadiazine, thiourea, their dérivatives and salts thereof.
According to an embodiment of the présent invention, the hydrophobie agrochemical active ingrédients are selected from the group comprising of fipronil, flubendiamide, clodinafop, metribuzin, diafenthiauron, indoxacarb, bifenthrin, fluazuron, atrazine, deltamethrin, rimsulfuron, imidacloprid, fomesafen, acifluorfen, azaconazole, azoxystrobin, benalaxyl, benodanil, 1, benzamacril, benzamacryl-isobutyl, bialaphos, binapacryl, biphenyl, bitertanol, blasticidin-S, bromuconazole, bupirimate, buthiobat, calcium polysulphide, capsimycin, carbendazim, carboxin, carvone, chinomethionat (quinomethionat), chlobenthiazone, chlorfenazole, chlorothalonil, chlozolinate, clozylacon, eufraneb, cymoxanil, cyproconazole, cyprodinil, cyproforam, debacarb, dichlorophen, diclobutrazol, diclofluanid, diclomezine, dicloran, diethofencarb, difenoconazole, diafenthiuron, dimethirimol, dithianon, dodemorph, dodine, drazoxolon, ediphenphos, epoxiconazole, etaconazole, ethirimol, etridiazole, famoxadone, fenapanil, fenarimol, fenbuconazole, fenfuram, fenitropan, 5 fenpiclonil, fenpropidin, fenpropimorph, fluquinconazole, flurprimidol, flusilazole, flusulphamide, flutolanil, imibenconazole, iminoctadine, iminoctadinealbesilate, iminoctadine, iprodione, irumamycin, isoprothiolane, isovaledione, kasugamycin, kresoxim-methyl, meferimzone, mepanipyrim, mepronil, metalaxyl, metconazole, methasulphocarb, methfiiroxam, myclobutanil, penconazole, pencycuron, phosdiphen, 1Q pimaricin, piperalin, polyoxin, polyoxorim, probenazole, prochloraz, procyinidone, propamocarb, propanosine-sodium, propiconazole, propineb, pyrazophos, pyrifenox, pyrimethanil, pyroquilon, pyroxyfur, Sulphur and sulphur préparations, tebuconazole, tecloftalam, tecnazene, tetcyclacis, tetraconazole, thiabendazole, , thifluzamide, thiophanate-methyl, tricyclazole, tridemorph, triflumizole, triforine, Ί 5 triticonazole, avermectin lorfenapyr fenazaquin, fenpyroximate, pyrimidifen, pyridaben, tebufenpyrad, tolfenpyrad Diafenthiuron spirodiclofen, spiromesifen amidoflumet, benclothiaz, benzoximate, bifenazate, bromopropylate, buprofezin, chinomethionat, chlordimeform, chlorobenzilate, chloropicrin, clothiazoben, cycloprene, dicyclanil, fenoxacrim, fentrifanil, flubenzimine, flufenerim, flutenzin, gossyplure, 20 hydramethylnone, japonilure, metoxadiazone, petroleum, piperonyl butoxide, potassium oleate, pyridalyl, sulphluramid, tetradifon, tetrasul, triarathene, chlorantraniliprole, chlorfenapyr, clothianidin, cyantraniliprole, diafenthiuron, emamectin benzoate, ethiprole, flupyradifurone, imidacloprid, indoxacarb, lambda cyhalothrin, lufenuron, methoxyfenozide, pymetrozine, pyrethrum, bistrifluoron, chlofluazuron, diflubenzuron, 25 fluazuron, flucycloxuron, flufenoxuron, hexaflumuron, lufenuron, novaluron, noviflumuron, penfluoron, teflubenzuronchromafenozide, halofenozide, methoxyfenozide and tebufenozide.
According to an embodiment of the présent invention, hydrophobie agrochemical active ingrédients are selected from the group comprising of fipronil, flubendiamide, 30 metribuzin, indoxacarb, diafenthiuron and bifenthnn.
According to the preferred embodiment of the présent invention, hydrophobie agrochemical active ingrédient is fipronil.
According to the preferred embodiment of the présent invention, hydrophobie agrochemical active ingrédient is diafenthiuron.
In an embodiment, the présent invention provides a stable insecticide composition comprising from about 0.1% w/w to about 90% w/w and preferably from about 1% w/w to about 80% w/w hydrophobie agrochemical active ingrédient of the total weight of the stable insecticide composition.
In a preferred embodiment of the présent invention, the stable insecticide composition q comprises from about 5% w/w to about 80% w/w hydrophobie agrochemical active ingrédient ofthe total weight ofthe stable agrochemical composition.
According to an embodiment of the présent invention, the stable insecticide composition comprises of a disintegration system.
According to an embodiment of the présent invention, the disintegration system 15 comprises of a polymer matrix and an inorganic sait.
The term ‘disintegration system’ used herein refers to disintegration system comprising a polymer matrix and an inorganic sait, in an effective ratio preferably from about 1:1 to about 1:4.
According to an embodiment of the présent invention, polymer matrix is selected from 2Q the group comprising of polyurea, polyvinyl chloride, polyuréthanes, polyamide, polyvinyl pyrrolidine, acrylic polymers, polyisocyanate-cyclic alkylene, polyamine, polyimine, polycarboxylic acids, naturally occurring polymers, their dérivatives and salts thereof.
According to an embodiment of the présent invention, naturally occurring polymers in polymer matrix is selected from the group comprising of kaolin, clay, bentonite, diatomaceous earth, zeolite, attapulgite, acid clay, talc and the like.
According to preferred embodiment of the présent invention, polymer matrix is polyurea 5 and polyuréthane.
According to preferred embodiment of the présent invention, polymer matrix is polyurea, also known as urea-formaldéhyde copolymer (Marketed as BC-700™, Urecoll®, Leaf®, E-Gen®, Meldur®, GripPro™).
In an embodiment, the présent invention provides a stable insecticide composition 10 comprising from about 0.1% w/w to about 50% w/w and preferably from about 1% w/w to about 30% w/w polymer matrix of the total weight of the stable insecticide composition.
In a preferred embodiment of the présent invention, the stable insecticide composition comprises from about 0.5% w/w to about 20% w/w polymer matrix of the total weight of Ί g the stable insecticide composition.
According to an embodiment of the présent invention, an inorganic sait of the stable insecticide composition is selected from the group comprising of ammonium sulfate, sodium sulfate, ammonium bicarbonate, sodium bicarbonate, magnésium sulfate, hydrogen carbonate, sodium chloride, sodium citrate, ammonium citrate, sodium acetate 20 bentonite, aluminium chloride, citric acid, succinic acid and the like.
According to preferred embodiment of the présent invention, inorganic sait is ammonium bicarbonate.
According to preferred embodiment of the présent invention, inorganic sait is ammonium sulfate.
According to preferred embodiment of the présent invention, inorganic sait is sodium citrate.
In an embodiment of the présent invention, a stable insecticide composition comprising from about 0.1% w/w to about 30% w/w and preferably from about 0.5% w/w to about 30% w/w inorganic sait of the total weight of the stable insecticide composition.
In a preferred embodiment of the présent invention, the stable insecticide composition comprises from about 1% w/w to about 20% w/w inorganic sait ofthe total weight of the stable insecticide composition.
According to an embodiment of the présent invention, the stable insecticide composition comprising:
at least one hydrophilic agrochemical active ingrédients selected from the group comprising of pyridine organic compound and organophosphorous compounds;
at least one hydrophobie agrochemical active ingrédient selected from the group comprising of phenyl pyrazole compound, diamide, triazine, pyrethroids, oxadiazine and thiourea class of compounds, and a disintegration System;
wherein disintegration System comprises of a polymer matrix and an inorganic sait in a ratio from about 1:1 to about 1 A.
In an embodiment, the disintegration System comprises of a polymer matrix and an inorganic sait in a ratio of about 1:1 or about 1:1.5 or about 1: 2 or about 1:2.5 or about 1:3 or about 1: 3.5 or about 1:4.
In preferred embodiment, the disintegration System comprises of a polymer matrix and an inorganic sait in a ratio of about 1:1.
In another embodiment, the disintegration System comprises of a polymer matrix and an inorganic sait in a ratio of about 1:4.
In another embodiment, according to the présent invention, dégradation of said agrochemical active ingrédients is controlled.
In another embodiment, according to the présent invention, dégradation of said agrochemical active ingrédients is controlled to <5%. The dégradation of said agrochemical active ingrédients in the présent composition is preferably controlled to <3%, more preferably <2% and most preferably <l%.The stable insecticide composition of the présent invention may further comprise one or more dispersants, wetting agents, fillers, surfactants, anticaking agents, pH-regulating agents, preservatives, biocides, antifoaming agents, colorants and other formulation aids.
The examples of dispersants may be selected from ionic and nonionic dispersants to enable disintegration of granules in water with ease, such as salts of polystyrène sulphonic acids, salts ofpolyvinylsulphonic acids, salts of naphthalenesulphonic acid/formaldehyde condensâtes, salts of condensâtes of naphthalenesulphonic acid, phenolsulphonic acid and formaldéhyde, and salts of lignosulphonic acid e.g frequently used dispersants are alkylnaphtalene sulphonates, for instance sodium diisopropylnaphthalene sulphonate and sodium alkylnaphthalene sulphonate, and lignosulphonate, such as sodium lignosulphonate and modified sodium lignosulfonate (Ufoxane 3A); polyethylene oxide/polypropylene oxide block copolymers, polyethylene glycol ethers of linear alcohols, reaction products of fatty acids with ethylene oxide and/or propylene oxide, furthermore polyvinyl alcohol, polyvinylpyrrolidone, copolymers of polyvinyl alcohol and polyvinylpyrrolidone and copolymers of (meth)acrylic acid and (meth)acrylic esters, furthermore alkyl ethoxylates and alkylarylethoxylates ethoxylated alkylarylphosphated and sulphated ester. The preferred dispersing agents include dérivative of ethoxylates of vegetable oil or a mixture of one or more of these; or styrene acrylic polymers or mixtures thereof
The examples of wetting agents may be selected from soaps; silicone oil, magnésium stéarate, salts of aliphatic monoesters of sulphuric acid including but not limited to sodium lauryl sulphate; sulfoakylamides and salts thereof including but not limited to Nmethyl-N-oleoyltaurate sodium sait; alkylarylsulfonates including but not limited to akylbenzenesulfonates; akyhiaphthalenesulfonates and salts thereof and salts of ligninsulfonic acid, e.g. sodium diisopropyl naphthalene sulfonate (Supragil WP).
In an embodiment the fillers may be selected from insoluble fillers and soluble fillers.
In an embodiment, the preferred fillers are selected from precipitated silica and diatomaceous earth kaolin.
In an embodiment, suitable antifoams may, preferably be, silicones, long-chain alcohols and salts of fatty acids.
Suitable colorants (for example in red, blue and green) are, preferably, pigments, which are sparingly soluble in water, and dyes, which are water-soluble. Examples are morgamc coloring agents (for example iron oxide, titanium oxide, and iron hexacyanoferrate) and organic coloring agents (for example alizarin, azo and phthalocyanin coloring agents).
According to an embodiment of the présent invention, the stable insecticide composition of the présent invention is preferably formulated as a solid composition including, but not limited to, dust, powder, granules, pellets, tablets, dry flowable, wettable powder or water dispersible granules (WDG).
In a preferred embodiment, the stable insecticide composition ofthe présent invention is a Water Dispersible Granules (WDG).
In an embodiment the présent invention provides a water dispersible granular formulation comprising:
at least one hydrophilic agrochemical active ingrédients selected from the group comprising of pyridine organic compound and organophosphorous compounds, at least one hydrophobie agrochemical active ingrédient selected from the group comprising of phenyl pyrazole compound, diamide, triazine, pyrethroids, oxadiazine and thiourea class of compounds; and a disintegration System;
wherein disintegration System comprises of a polymer matrix and an inorganic sait.
Inventors of the présent invention successfully prepared the insecticidal compositions of agrochemically active ingrédients as well as combination of agrochemically active ingrédients with diverse solubility profile using disintegration System comprising a polymer matrix and inorganic sait. The compositions of hydrophilic agrochemical active ingrédient, hydrophobie agrochemical active ingrédient along with disintegration System surprisingly found to remain stable with desired suspensibility and dispersibility. Also, agrochemical active ingrédients remain quite stable without any significant dégradation of the actives in various compositions developed according to the présent invention. The présent composition also demonstrate reduced use rates as well as réduction in dust 1Q hazard.
According to an embodiment of the présent invention, the stable insecticide composition comprises of flonicamid and a disintegration System comprises of a polymer matrix and an inorganic sait in a ratio from about 1:1 to about 1:4.
According to an embodiment of the présent invention, the stable insecticide composition 15 comprises of fipronil and a disintegration System comprises of a polymer matrix and an inorganic sait in a ratio from about 1:1 to about 1:4.
According to an embodiment of the présent invention, the stable insecticide composition comprises of fipronil, flonicamid and a disintegration System comprises of a polymer matrix and an inorganic sait in a ratio from about 1:1 to about 1:4. According to an 2Q embodiment of the présent invention, the stable insecticide composition comprises of diafenthiuron, flonicamid and a disintegration System comprises of a polymer matrix and an inorganic sait in a ratio from about 1:1 to about 1:4.
According to an embodiment of the présent invention, the stable insecticide composition comprises of fipronil, pymetrozine and a disintegration System comprises of a polymer 25 matrix and an inorganic sait in a ratio from about 1:1 to about 1 A.
In preferred embodiment the water dispersible granular formulation comprising.
at least one hydrophilic agrochemical active ingrédients selected from the group comprising of pyridine organic compound and organophosphorous compounds;
at least one hydrophobie agrochemical active ingrédient selected from the group comprising of phenyl pyrazole compound, diamide, triazine, pyrethroids, oxadiazine and thiourea class of compounds; and a disintegration System;
wherein disintegration System comprises of a polymer matrix and an inorganic sait in a ratio from about 1:1 to about 1:4.
In preferred embodiment, the présent invention provides a water dispersible granular formulation comprising
i) flonicamid and ii) a disintegration System comprises of a polymer matrix and an inorganic sait in a ratio from about 1:1 to about 1:4.
In preferred embodiment, the présent invention provides a water dispersible granular formulation comprising
i) Fipronil and ii) a disintegration System comprises of a polymer matrix and an inorganic sait in a ratio from about 1:1 to about 1 A.
In another preferred embodiment, the présent invention provides a water dispersible granular formulation comprising
i) Flonicamid;
ii) Fipronil and iii) a disintegration System comprises of a polymer matrix and an inorganic sait in a ratio from about 1:1 to about 1:4.
In another preferred embodiment, the présent invention provides a water dispersible granular formulation comprising
i) Flonicamid;
ii) Difenthiuron and iii) a disintegration System comprises of a polymer matrix and an inorgamc sait in a ratio from about 1:1 to about 1 A.
In another preferred embodiment, the présent invention provides a water dispersible granular formulation comprising
i) Pymetrozine ;
ii) Fipronil and iii) a disintegration system comprises of a polymer matrix and an inorganic sait in a ratio from about 1:1 to about 1:4.
In an embodiment, the présent invention provides a stable insecticide composition comprising from about 0.1% w/w to about 90% w/w hydrophihc agrochemical active ingrédient, and from about 0.1% w/w to about 30% w/w disintegration system with polymer matrix and inorganic sait in a ratio 1:1 to 1:4 of the total weight of the composition.
In an embodiment, the présent invention provides a stable insecticide composition comprising from about 0.1% w/w to about 80% w/w hydrophihc agrochemical active ingrédient, and from about 0.1% w/w to about 30% w/w disintegration system with polymer matrix and inorganic sait in a ratio 1:1 to 1:4 of the total weight of the composition.
In a preferred embodiment, the présent invention provides a stable insecticide composition comprising from about 50% w/w to about 90% w/w flonicamid, from about 0.1% w/w to about 20% w/w ammonium sulfate and from about 0.1% w/w to 20% w/w urea-formaldehyde copolymer of the total weight of the composition.
In an embodiment, the présent invention provides a stable insecticide composition comprising from about 0.1% w/w to about 90% w/w hydrophobie agrochemical active ingrédient, and from about 0.1% w/w to about 30% w/w disintegration system with polymer matrix and inorganic sait in a ratio 1:1 to 1:4 of the total weight of the composition.
In an embodiment, the présent invention provides a stable insecticide composition comprising from about 0.1% w/w to about 80% w/w hydrophobie agrochemical active ingrédient, and from about 0.1% w/w to about 30% w/w disintegration System with polymer matrix and inorganic sait in a ratio 1:1 to 1:4 of the total weight of the 5 composition.
In a preferred embodiment, the présent invention provides a stable insecticide composition comprising from about 50% w/w to about 90% w/w fipronil, from about 0.1% w/w to about 20% w/w ammonium sulfate and from about 0.1% w/w to 20% w/w urea-formaldehyde copolymer of the total weight of the composition.
-| q In an embodiment, the présent invention provides a stable insecticide composition comprising from about 0.1% w/w to about 90% w/w hydrophilic agrochemical active ingrédient, from about 0.1% w/w to about 90% w/w hydrophobie agrochemical active ingrédient, and from about 0.1% w/w to about 30% w/w disintegration System with polymer matrix and inorganic sait in a ratio 1:1 to 1:4 of the total weight of the Ί 5 composition.
In a preferred embodiment, the présent invention provides a stable insecticide composition comprising from about 5% w/w to about 80% w/w hydrophilic agrochemical active ingrédient, from about 5% w/w to about 80% w/w hydrophobie agrochemical active ingrédient and from about 0.1% w/w to about 30% w/w disintegration System with 20 polymer matrix and inorganic sait in a ratio from about 1:1 to about 1:4 of the total weight of composition.
In a preferred embodiment, the présent invention provides a stable insecticide composition comprising from about 5% w/w to about 80% w/w flonicamid, from about 5% w/w to about 80% w/w fipronil, from about 1% w/w to about 20% w/w ammonium 25 sulfate and from about 1% w/w to about 20% w/w urea-formaldehyde copolymer of the total weight of tire composition.
In a preferred embodiment, the présent invention provides a stable insecticide composition comprising from about 5% w/w to about 30% w/w flonicamid, from about 5% w/w to about 30% w/w fipronil, from about 0.1% w/w to about 20% w/w ammonium sulfate and from about 0.1% w/w to 20% w/w urea-formaldehyde copolymer of the total weight ofthe composition.
In a preferred embodiment, the présent invention provides a stable insecticide composition comprising from about 5% w/w to about 30% w/w flonicamid, from about 5% w/w to about 70% w/w diafenthiuron, from about 0.1% w/w to about 20% w/w ammonium sulfate and from about 0.1% to 20% w/w urea-formaldehyde copolymer of the total weight of the composition.
In a preferred embodiment, the présent invention provides a stable insecticide composition comprising from about 5% w/w to about 30% w/w fipronil, from about 5% w/w to about 40% w/w pymetrozine, from about 0.1% w/w to about 20% w/w ammonium sulfate and from about 0.1% w/w to 20% w/w urea-formaldehyde copolymer of the total weight ofthe composition.
In one preferred embodiment of the présent invention, the stable insecticide composition comprising from about 50% w/w to about 90% w/w flonicamid, from about 0.1% w/w to about 20% w/w ammonium sulfate and from about 0.1% w/w to 20% w/w ureaformaldehyde copolymer of the total weight of the stable insecticide composition and wherein said composition is in the form of water dispersible granules.
In an embodiment of the présent invention, the stable insecticide composition comprising from about 50% w/w to about 90% w/w fipronil, from about 0.1% w/w to about 20% w/w ammonium sulfate and from about 0.1% w/w to 20% w/w urea-formaldehyde copolymer of the total weight of the stable insecticide composition and wherein said stable insecticide composition is in the form of water dispersible granules.
In another preferred embodiment of the présent invention the stable insecticide composition comprising from about 5% w/w to about 30% w/w flonicamid, from about
5% w/w to about 30% w/w fipronil, from about 0.1% w/w to about 20% w/w ammonium sulfate and from about 0.1% w/w to 20% w/w urea-formaldehyde copolymer of the total weight of the stable insecticide composition and wherein said stable insecticide composition is in the form of water dispersible granules.
In a preferred embodiment, the présent invention provides a stable insecticide composition comprising from about 5% w/w to about 30% w/w flonicamid, from about 5% w/w to about 70% w/w diafenthiuron, from about 0.1% w/w to about 20% w/w ammonium sulfate and from about 0.1% to 20% w/w urea-formaldehyde copolymer of the total weight of the composition.
In a preferred embodiment, the présent invention provides a stable insecticide composition comprising from about 5% w/w to about 30% w/w fipronil, from about 5% w/w to about 40% w/w pymetrozine, from about 0.1% w/w to about 20% w/w ammonium sulfate and from about 0.1% w/w to 20% w/w urea-formaldehyde copolymer of the total weight of the composition.
In another embodiment the insecticide composition according to the présent invention can comprises another insecticide selected from group of Acetylcholinesterase (AChE) inhibitors, GABA -gated chloride channel blockers, Sodium channel modulators, Nicotinic acétylcholine receptor (nAChR) compétitive modulators, Nicotinic acétylcholine receptor (nAChR) allosteric modulators, Glutamate -gated chloride channel (GluCl) allosteric modulators, Juvénile hormone mimics, Chordotonal organ TRPV channel modulators, Mite growth inhibitors, Microbial disruptors of insect midgut membranes, Inhibitors of mitochondrial ATP synthase, Uncouplers of oxidative phosphorylation via disruption of the proton gradient, Nicotinic acétylcholine receptor (nAChR) channel blockers, Inhibitors of chitin biosynthesis , Moulting disruptors, Ecdysone receptor agonists, Octopamine receptor agonists, Mitochondrial complex électron transport inhibitors, Voltage-dependent sodium channel blockers, Inhibitors of acetyl CoA carboxylase, Chordotonal organ Modulators, multi-site miscellaneous insecticides, bioinsecticides and mixtures thereof.
According to an embodiment of the présent invention, a process for préparation of stable insecticide composition, said process comprising steps of:
i) mixing an agrochemically active ingrédient, a polymer matrix and an inorganic sait and blending to obtain blend;
ii) grinding said blend to obtain grounded mix of desired particle size;
iii)blending said grounded mix to obtain homogeneous mixture;
iv)preparing dough from said homogeneous mixture and perform granulation and v) drying the granules.
According to an embodiment of the présent invention, a process for préparation of stable j Q insecticide composition, said process comprising steps of:
i) adding hydrophilic agrochemical active ingrédient, hydrophobie agrochemical active ingrédient, a polymer matrix and an inorganic sait and blending it to obtain blend;
ii) grinding said blend to obtain grounded mix of desired particle size;
Ί 5 iii)blending said grounded mix to obtain homogeneous mixture;
iv)preparing dough from said homogeneous mixture and perform granulation;
v) drying the granules.
According to an embodiment of the présent invention, provided is a process for the préparation of a water dispersible granular formulation comprising flonicamid and 20 fipronil.
According to an embodiment ofthe présent invention, the process for préparation of water dispersible granular formulation comprising the steps of:
i) adding flonicamid, fipronil, ammonium sulfate, urea-formaldehyde copolymer and other auxiliary ingrédients and blending it to obtain the blend;
ii) grinding said blend to obtain grounded mix of desired particle size;
iii)blending said grounded mix to obtain homogeneous mixture;
iv)preparing dough from said homogeneous mixture by adding water and extrade the granules;
v) drying the extraded granules.
According to an embodiment of the présent invention, the order of addition and mixing ofthe granule ingrédients is not narrowly critical. In one embodiment, for example, the dry ingrédients are blended and the composition is then mixed while water is added.
According to an embodiment of the présent invention, water may be added as a fine spray to préparé dough from the composition to obtain granules.
According to an embodiment of the présent invention, one or more formulation auxiliaries are added in water to préparé aqueous solution and said aqueous solution is added to préparé dough from the composition to obtain granules.
According to an embodiment of the présent invention, the blend of above ingrédients is q obtained using a suitable blender such as ribbon blender, V-blender, high intensity plow mixer or the like.
According to an embodiment of the présent invention, the grinding may be performed in a suitable device known to a skilled person in the relevant art such as air jet mill, air classifier mill, hammer mill, pin dise mill or the like. Jet mills are shear or pulverizing Ί 5 machines in which the particles to be milled are accelerated by gas flows and pulverized by collision. There are a number of different types of jet mill designs, such as double counterflow (opposing jet) and spiral (pancake) fluid energy mills.
According to an embodiment of the présent invention, water dispersible granules are typically prepared through an extrusion process or pan granulation process.
2Q According to an embodiment of the présent invention, drying of granules may be performed in a suitable drying equipment such as spray drier or fluidized bed spray drier or fluid bed spray granulator.
According to an embodiment of the présent invention, the drying of extruded granules opérâtes at a température not more than 90°C-100°C.
According to preferred embodiment of the présent invention, the drying of granules opérâtes at a température range of 50°C -70°C.
The drying process will preferably remove as much water as possible in order to reduce weight and to provide good stability to the granules while still in a dry flowable State. Preferably the granules will be dried to less than 2% as weight loss on complété drying and most preferably dried to less than 0.5% as weight loss on complété drying.
According to an embodiment of the présent invention, materials used in the process of the invention may be in a fînely divided form, preferably in an air-milled form which is generally the form of technical grade Chemicals supplied by manufacturera.
After thorough mixing or after otherwise putting the mix into a form suitable for extrusion, extrusion takes place through suitable orifices. The size of the granules will dépend upon the size of the orifices and the extruder may thus be fitted with a mesh or die selected to provide a desired size of granule. Preferably extrusion orifices will be chosen to provide extrusions between 300 and 1000 microns in diameter. The extrusions can vary considerably in length, e.g. up to 0.5 cm or more long.
In an embodiment of the présent invention, pH of the stable insecticide composition is adjusted between 5 to 8.
In an embodiment of the présent invention, the process of preparing stable insecticide composition comprises steps of:
i) adding hydrophilic agrochemical active ingrédient, hydrophobie agrochemical active ingrédient, a polymer matrix and an inorganic sait and blending it to obtain blend;
ii) grinding said blend to obtain grounded mix of desired particle size; iii)blending said grounded mix to obtain homogeneous mixture and iv) preparing dough from said homogeneous mixture and perform granulation to obtain tire composition.
The granules thus obtained by granulation are subjected to drying at température lesser than 100°C to reduce moisture content less than 0.5% to obtainthe finished composition.
It will be évident to those skilled in the art that one significant advantage of the process of the présent invention is that the extrusions are not reduced (e.g. by cutting) to granules as they exit the extrader. This means that the rate of extrusion is not limited by the rate at which the extrusions can be broken down into granules and high extrusion rates can be used. This results in the process of the présent invention being significantly more costeffective than prior art extrusion processes for producing water dispersible granules.
Tire process of the invention considerably reduces the amount of oversized and Q undersized material which must be recycled. Consequently, the granule composition is essentially dust free.
According to an embodiment of the présent invention, tire stable insecticide composition is used as pesticide to control insects in the agriculture field.
According to an embodiment of the présent invention, the stable insecticide composition j g is effective as pesticides, for example, insecticides, miticides, nematicides and soil pesticides. For instance, the stable insecticide composition is against plant parasitic mites such as two-spotted spidermite (Tetranychus urticae), carminé spidermite (Tetranychus cinnabarinus) or citras red mite (Panonychus citri) or bulb mite (Rhizoglyphus echinopus); aphids such as green peach aphid (Myzus persicae) or cotton aphid (Aphis 20 gossypii); agricultural insect pests such as diamondback moth (Plutella xylostella), cabbage armyworm (Mamestra brassicae), common cutworm (Spodoptera litura), Colorado potato beetle (Leptinotarsa decemlineata), codling moth (Laspeyresia pomonella), bollworm (Heliothis zea), tobacco budworm (Heliothis virescens), boll weevil (Anthonomus grandis), gypsy moth (Lymantria dispar), cucurbit leaf beetle 25 (Aulacophora femoralis), planthoppers, leafhoppers, scales, bugs, whiteflies, thrips, grasshoppers, anthomyiid flies, scarabs, black cutworm (Agrotis ipsilon), cutworm (Agrotis segetum) or ants; hygienic insect pests such as tropical rat mite (Omithonyssus bacoti), cockroaches, housefly (Musca domestica) or house mosquito (Culex pipiens pallens); stored grain insect pests such as angoumois grain moth (Sitotroga cerealella), azuki bean weevil (Callosobruchus chinensis), confused flour beetle (Tribolium confusum) or mealworms; household goods insect pests such as casemaking clothes moth (Tinea pellionella), black carpet beetle (Anthrenus scrophularidae) or subterranean ; termites; and other parasites on domestic animais such as fleas, lice or flies. Further, said composition is effective against insect pests such as aphids having acquired résistance to organophosphorus, carbamate and/or synthetic pyrethroid insecticides. Moreover, the agrochemically active ingrédients of the présent invention hâve excellent systemic properties, and by the application of the compounds of the présent invention to soil 10 treatment, not only noxious insects, noxious mites, noxious nematodes, noxious gastropods and noxious isopods in soil but also foliage pests can be controlled.
The compositions of the présent invention can be used in agricultural lands such as fields, paddy fields, lawns and orchards or in non-agricultural lands. The présent invention may be used to control diseases in agricultural lands for cultivating the plants without any 25 phytotoxicity to the plant.
Examples of the crops on which the présent compositions may be used include but are not limited to corn, rice, wheat, barley, rye, oat, sorghum, cotton, soybean, peanut, buckwheat, beet, rapeseed, sunflower, sugar cane, tobacco, etc.; vegetables: solanaceous vegetables such as eggplant, tomato, pimento, pepper, potato, etc., cucurbit vegetables 2Q such as cucumber, pumpkin, zucchini, water melon, melon, squash, etc., cruciferous vegetables such as radish, white tumip, horseradish, kohlrabi, Chinese cabbage, cabbage, leaf mustard, broccoli, cauliflower, etc., asteraceous vegetables such as burdock, crown daisy, artichoke, lettuce, etc, liliaceous vegetables such as green onion, onion, garlic, and asparagus, ammiaceous vegetables such as carrot, parsley, celery, parsnip, etc., 25 chenopodiaceous vegetables such as spinach, Swiss chard, etc., lamiaceous vegetables such as Perilla frutescens, mint, basil, etc, strawberry, sweet potato, Dioscorea japonica, colocasia, etc., flowers, foliage plants, turf grasses, fruits: pome fruits such apple, pear, quince, etc, stone fleshy fruits such as peach, plum, nectarine, Prunus mume, cherry fruit, apricot, prune, etc., citrus fruits such as orange, lemon, rime, grapefruit, etc., nuts such 30 as chestnuts, walnuts, hazelnuts, almond, pistachio, cashew nuts, macadamia nuts, etc.
bernes such as blueberry, cranberry, blackberry, raspberry, etc., grape, kaki fruit, olive, plum, banana, coffee, date palm, coconuts, etc., trees otherthan fruit trees; tea, mulberry, flowering plant, trees such as ash, birch, dogwood, Eucalyptus, Ginkgo biloba, lilac, maple, Quercus, poplar, Judas tree, Liquidambar formosana, plane tree, zelkova, Japanese
- arborvitae, fir wood, hemlock, juniper, Pinus, Picea, and Taxus cuspidate, etc.
According to an embodiment of the présent invention, the stable insecticide composition comprising:
at least one agrochemical active ingrédient; and a disintegration System
Q wherein said disintegration System comprises of a polymer matrix and an inorganic sait and said compositionis useful in combatting insects such as while flies, mites, fruit borers and larvae.
According to an embodiment of the présent invention, a method of controlling unwanted pests, said method comprising applying to the pests or to their locus, an agrochemically g effective arnount of stable agrochemical compositions comprising:
at least one agrochemical active ingrédient; and a disintegration System, wherein said disintegration System comprises of a polymer matrix and an inorganic sait.
According to an embodiment of the présent invention, a method of controlling unwanted 2Q pests, said method comprising applying an agrochemically effective amount of stable agrochemical compositions comprising:
at least one hydrophilic agrochemical active ingrédient;
at least one hydrophobie agrochemical active ingrédient; and a disintegration System, wherein disintegration System comprises of a polymer matrix and an inorganic sait in a ratio from about 1:1 to about 1:4.
According to an embodiment of the présent invention, a method of controlling unwanted pests, said method comprising applying an agrochemically effective amount of stable agrochemical compositions to the pests or to their locus, said composition comprising flonicamid, fipronil, and a disintegration System comprising urea-formaldehyde copolymer and ammonium sulfate
According to an embodiment the compositions of the présent invention can be in the form of a multi-pack product or as a kit-of-parts for controlling insects.
According to an embodiment ofthe présent invention, the kit comprising:
at least one agrochemical active ingrédient; and a disintegration System, wherein said disintegration System comprises of a polymer matrix and an inorganic sait. In one embodiment of the présent invention, the kits may include one or more, including ail, components that may be used to préparé the stable insecticide composition. E. g., kits may include hydrophilic agrochemical active ingrédient, hydrophobie agrochemical active ingrédient, and/or disintegration System. One or more of the components may already be combined together or pre-formulated. In those embodiments where more than two components are provided in a kit, the components may already be combined together and as such are packaged in a single container such as a vial, bottle, can, pouch, bag or canister.
In other embodiments, two or more components of a kit may be packaged separately, i. e., not pre-formulated. As such, kits may include one or more separate containers such as vials, cans, bottles, pouches, bags or canisters, each container containing a separate component for stable insecticide composition.
In both forrns, a component of the kit may be applied separately from or together with the further components or as a component of a combination composition according to the invention for preparing the stable insecticide composition according to the invention.
In an embodiment of the présent invention, the stable insecticide comprising (a) at least one agrochemical active ingrédient, and (b) disintegration System is in the form of a kit with single pack or multi pack.
In an embodiment of the présent invention, the stable insecticide composition comprising (a) at least one hydrophilic agrochemical active ingrédient (b) at least one hydrophobie active ingrédient and (c) disintegration System is in the form of a kit with single pack or multi pack.
In an embodiment, the multi-pack herbicidal product comprises a package holding a composition comprising at least one agrochemical active ingrédient selected from hydrophobie and hydrophilic agrochemical active ingrédient; and a disintegration System, wherein said disintegration System comprises of a polymer matrix and an inorganic sait.
It will be understood that the spécification and examples are illustrative but not limitative of the présent invention and that other embodiments within the spirit and scope of the invention will suggest themselves to those skilled in the art. Other embodiments can be practiced that are also within the scope ofthe présent invention. The following examples illustrate the invention, but by no means intend to limit the scope of the claims.
Example 1: Préparation of Flonicamid 50% WDG
# Ingrédients Amount ( %)
1 Flonicamid 50
2 Modified Sodium lignosulfonate 6
3 Sodium lignosulfonate 10
4 Sodium Isopropyl Naphthalene Sulfonate 6
5 Ammonium Sulphate 5
6 Urea-formaldehyde copolymer 5
7 Silicone defoamer 0.5
8 Kaolin 17.5
Total 100
Modified Sodium lignosulfonate (Ufoxane 3A); Sodium Isopropyl Naphthalene Sulfonate (Supragil WP); Urea-formaldehyde copolymer (BC-700); Silicone defoamer (SAG 1572).
Above mentioned ingrédients in specified quantity were added and blended in a ribbon blender for 20-30 min to obtain blend. The blend was further grounded in air jet mill to obtain grounded mix having particle size Dioo below 30 micron. The grounded mix for then blended for 40-50 min to obtain homogeneous mixture. The homogeneous mixture was taken to préparé dough using water spray. Granules were then extruded in a granulator having sieve size 0.8 to 1.2 mm aperture. The extruded granules were dried on fluid bed dryer at température ranging between 50°C to 70°C. The dried granules were passed through sieve to obtain uniformly sized granules. Undersized and oversized granules were recycled back. Finished granules were packed in a suitable packaging.
The formulations in the following examples are prepared according to the process described in example 1.
Example 2: Préparation of Flonicamid 50% WDG
# Ingrédients Amount (%)
1 Flonicamid 50
2 Modified sodium lignosulphonate 6
3 Sodium lignosulfonate 10
4 Sodium Isopropyl Naphthalene Sulfonate 6
5 Ammonium Sulphate 20
6 Urea-formaldehyde copolymer 5
7 Silicone defoamer 0.5
8 Kaolin 2.5
Total 100
Example 3: Préparation of Flonicamid 50% WDG (comparative example)
# Ingrédients Amount ( %)
1 Flonicamid 50
2 Modified sodium lignosulfonate 6
3 Sodium lignosulfonate 10
4 Sodium Isopropyl Naphthalene Sulfonate 6
5 Urea-formaldehyde copolymer 5
6 Silicone defoamer 0.5
7 Kaolin 22.5
Total 100
Example 4: Préparation of Flonicamid 50% WDG (comparative example)
# Ingrédients Amount ( %)
1 Flonicamid 50
2 Modified sodium lignosulfonate 6
3 Sodium lignosulfonate 10
4 Sodium Isopropyl Naphthalene Sulfonate 6
5 Ammonium Sulphate 20
6 SAG 1572 0.5
7 Kaolin 7.5
Total 100
Example 5: Préparation of Flonicamid 50% WDG (comparative example)
# Ingrédients Amount ( %)
1 Flonicamid 50
2 Modified sodium lignosulfonate 6
3 Sodium lignosulfonate 10
4 Sodium Isopropyl Naphthalene Sulfonate 6
5 Silicone defoamer 0
6 Kaolin 27.5
Total 100
Example 6: Préparation of Fipronil 80% WDG
# Ingrédients Amount ( %)
1 Fipronil 80
2 Modified sodium lignosulfonate 3
3 Sodium lignosulfonate 8
4 Sodium Isopropyl Naphthalene Sulfonate 2
5 Ammonium Sulphate 2
6 Urea-formaldehyde copolymer 2
7 Kaolin 3
Total 100
Example 7: Préparation of Fipronil 80% WDG
# Ingrédients Amount ( %)
1 Fipronil 80
2 Modified sodium lignosulfonate 3
3 Sodium lignosulfonate 8
4 Sodium Isopropyl Naphthalene Sulfonate 2
5 Ammonium Sulphate 5
6 Urea-formaldehyde copolymer 2
Total 100
Example 8: Préparation of Fipronil 80% WDG (comparative example)
# Ingrédients Amount ( %)
1 Fipronil 80
2 Modified sodium lignosulfonate 3
3 Sodium lignosulfonate 8
4 Sodium Isopropyl Naphthalene Sulfonate 2
5 Urea-formaldehyde copolymer 2
6 Kaolin 5
Total 100
Example 9: Préparation of Fipronil 80% WDG (comparative example)
# Ingrédients Amount ( %)
1 Fipronil 80
2 Modified sodium lignosulfonate 3
3 Sodium lignosulfonate 8
4 Sodium Isopropyl Naphthalene Sulfonate 2
5 Ammonium Sulphate 5
6 Kaolin 2
Total 100
Example 10: Préparation of Fipronil 80% WDG (comparative example)
# Ingrédients Amount ( %)
1 Fipronil 80
2 Modified sodium lignosulfonate 3
3 Sodium lignosulfonate 8
4 Sodium Isopropyl Naphthalene Sulfonate 2
5 Kaolin 7
Total 100
Example 11: Préparation of Fipronil 15% and Flonicamid 15% WDG
# Ingrédients Amount ( %)
1 Fipronil 16.05
2 Flonicamid 16
3 Modified sodium lignosulfonate 6
4 Sodium lignosulfonate 10
5 Sodium Isopropyl Naphthalene Sulfonate 6
6 Ammonium Sulphate 7
7 Urea-formaldehyde copolymer 2
8 Silicone defoamer 0.5
9 Kaolin 36.45
Total 100
Example 12: Préparation of Fipronil 15% and Flonicamid 15% WDG
# Ingrédients Amount ( %)
1 Fipronil 16.05
2 Flonicamid 16
3 Modified sodium lignosulfonate 6
4 Sodium lignosulfonate 10
5 Sodium Isopropyl Naphthalene Sulfonate 6
6 Ammonium Sulphate 2
7 Silicone defoamer 0.5
8 Urea-formaldehyde copolymer 2
10 Kaolin 41.45
Total 100
Example 13: Préparation of Fipronil 15% and Flonicamid 15% WDG (comparative example)
# Ingrédients Amount ( %)
1 Fipronil 16.05
2 Flonicamid 16
3 Modified sodium lignosulfonate 6
4 Sodium lignosulfonate 10
5 Sodium Isopropyl Naphthalene Sulfonate 6
6 Urea-formaldehyde copolymer 2
7 Silicone defoamer 0.5
8 Kaolin 43.45
Total 100
Example 14: Préparation of Fipronil 15% and Flonicamid 15% WDG (comparative example)
# Ingrédients Amount ( %)
1 Fipronil 16.05
2 Flonicamid 16
3 Modified sodium lignosulfonate 6
4 Sodium lignosulfonate 10
5 Sodium Isopropyl Naphthalene Sulfonate 6
6 Ammonium Sulphate 7
8 Silicone defoamer 0.5
9 Kaolin 38.45
Total 100
Example 15: Préparation of Fipronil 15% and Flonicamid 15% WDG (comparative example)
# Ingrédients Amount ( %)
1 Fipronil 16.05
2 Flonicamid 16
3 Modified sodium lignosulfonate 6
4 Sodium lignosulfonate 9
5 Sodium Isopropyl Naphthalene Sulfonate 6
6 Ammonium Sulphate 2
7 Silicone defoamer 0.5
8 Urea-formaldehyde copolymer 7
9 Kaolin 40.45
Total 100
Example 16: Fipronil 30% + Flonicamid 30 % w/w WDG
# Ingrédients Amount (%)
1 Fipronil 31.63
2 Flonicamid 31.5
3 Modified sodium lignosulfonate 6
4 Sodium Lignosulphonate 10
5 Sodium alkyl naphthalene sulfonate blend 6
6 Ammonium Sulphate 7
7 Silicone defoamer 0.5
8 Urea-formaldehyde copolymer 2
9 Kaolin 5.37
Total 100
Sodium alkyl naphthalene sulfonate blend (Morwet D425)
Example 17: Fipronil 10% + Flonicamid 10 % w/w WDG
# 1 Ingrédients Amount (%)
1 Fipronil 10.5
2 Flonicamid 10.4
3 Alkylnaphthalene sulfonate (ANS) condensate 6
4 Sodium Lignosulphonate 12
5 Sodium lauryl sulphate 7
6 Ammonium Sulphate 7
7 Silicone defoamer 0.5
8 Urea-formaldehyde copolymer 4
9 Kaolin 42.6
Total 100
Example 18: Diafenthiuron 60% + Flonicamid 20 % w/w WDG
# Ingrédients Amount (%)
1 Diafenthiuron 62
2 Flonicamid 21
3 Modified styrene acrylic polymer 8.5
4 Sodium Isopropyl Naphthalene Sulfonate 6
5 Ammonium Sulfate 1
6 Urea-formaldehyde copolymer 1
7 Silicone defoamer 0.5
Total 100
Example 19: Pymetrozine 35% + Fipronil 8% w/w WDG
# Ingrédients Amount (%)
1 Pymetrozine 36
2 Fipronil 21
3 Potassium polycarboxylate 3
4 Sodium lignosulphonate 12
5 Ammonium Sulfate 3
6 Urea-formaldehyde copolymer 3
7 Silicone defoamer 0.5
8 Kaolin 29
Total 100
Potassium polycarboxylate (Geropon SC/213)
Example 20
STABILITY DATA
Test for Dispersibility:
Compositions (as described above in Examples 1-10) prepared according to the présent invention were tested for stability. The samples were prepared using varied quantities of the active ingrédients and other ingrédients as listed in the below table (Table 1). The samples were prepared as per the process given in Example 1. The samples were tested for dispersibility by observing the number of inversions required to achieve complété dispersion of active ingrédients.
Table 1
Ingrédients Examples
Number 1 2 3 4 5 6 7 8 9 10
A 50 50 50 50 50 X X X X X
B X X X X X 80 80 80 80 80
C 5 5 5 X X 2 2 2 X X
D 5 20 X 20 X 2 5 X 5 X
E 6 6 6 6 6 3 3 3 3 3
F 10 10 10 10 10 8 8 8 8 8
G 6 6 6 6 6 2 2 2 2 2
H 0.5 0.5 0.5 0.5 0.5 X X X X X
I 18.5 2.5 22.5 7.5 27.5 3 0 5 2 7
No. of Inversions 10- 11 10- 11 24- 25 19- 20 22-23 11-12 10- 11 19- 20 20- 21 25- 26
A: Flonicamid, B: Fipronil, C: BC-700, D: Ammonium Sulfate, E: Ufoxane 3A, F: Sodium Lignosulfonate, G: Supragil WP, H: SAG 1572,1: Kaolin.
Number of inversions required to achieve complété dispersion of the granules was determined by the following procedure: A graduated cylinder of 250 ml was taken and 2 gm sample was added to the cylinder. It was allowed to soak for 2 min. The graduated cylinder was then closed by putting stopper and tilted to 180 °C and brought back to the original position in 2 seconds.
It was observed that the compositions comprising disintegration System (i.e. both ammonium sulfate and BC-700) found to hâve good disintegration profile as the । q dispersion is achieved in approx. 10-12 inversions and is highly suitable for end use. The composition according to the présent invention works better at ratio ranging of ammonium sulfate and BC-700 from 1:1 to 1:4. The compositions of Example 3, 4, 5, 8, 9 & 10 which does not hâve disintegration system according to the présent invention failed to give desired dispersion even in 19-26 inversions and hence found to be 15 unsuitable.
Similarly, compositions (Examples 11-15) were prepared by incorporating two agrochemically active ingrédients, viz. fipronil (hydrophobie agrochemical active ingrédient) and flonicamid (hydrophilic agrochemical active ingrédient) according to the présent invention and tested for stability. The samples were prepared using varied 20 quantifies of the active ingrédients and other ingrédients as listed in the below table (Table 2). The samples were prepared as per the process given in Example 1. The samples were tested for dispersibility by observing the number of inversions required to achieve complété dispersion of active ingrédients.
Table 2
Ingrédients Examples
Number 11 12 13 14 15
Fipronil 16.05 16.05 16.05 16.05 16.05
Flonicamid 16 16 16 16 16
BC-700 2 2 2 0 7
Ammonium sulfate 7 2 0 7 2
Ufoxane 3A 6 6 6 6 6
Sodium Lignosulphonate 10 10 10 10 10
Supragil WP 6 6 6 6 6
Sag-1572 0.5 0.5 0.5 0.5 0.5
Kaolin 36.45 41.45 43.45 38.45 41.45
No. of Inversions 11-13 13-15 25-30 20-25 20-25
Number of inversions required to achieve complété dispersion of the granules was determined by the following procedure: A graduated cylinder of 250 ml was taken and 2 gm sample was added to the cylinder. It was allowed to soak for 2 min. The graduated cylinder was then closed by putting stopper and tilted to 180 °C and brought back to the original position in 2 seconds.
It was observed that the compositions comprising disintegration System (i.e. both ammonium sulfate and BC-700) found to hâve good disintegration profile as the dispersion is achieved in approx. 11-15 inversions and is highly suitable for end use. The composition according to the présent invention works better at both ratio ranging of ammonium sulfate and BC-700 from 1:1 to 1:4. The compositions of Example 13, 14 & 15 devoid of disintegration System according to the présent invention failed to give desired dispersion even in 19-26 inversions.
Example 21
Test for suspensibility and stability of the active ingrédient
The WDG compositions of Example-1 and Example-6 prepared according to the présent invention were investigated for suspensibility, dégradation of active ingrédient as well as 5 its effect on stability of the composition. The stability study was conducted for zéro days, days AHS (Accelerated Heat Stability) at 54±2°C and for 30 months RT (Real Time) Parameters such as suspensibility, wet sieve analysis and dégradation of active ingrédients were tested for 0, 14 and 30 months respectively. The results are summarized in Table 3.
Table 3
Physico/Chemical property Example 1 Example 6
0 days 14 days 30 months 0 days 14 days 30 months
% dégradation Fipronil NA NA NA 0.0 0.14 0.11
% dégradation Flonicamid 0.0 0.2 0.16 NA NA NA
No. of Inversions 11-13 12-14 11-13 12-14 14-15 12-14
Suspensibility 91.30 90.60 90.80 83.20 81.90 82.80
As clear from Table 3, dégradation of active flonicamid and active fipronil in respective WDG compositions was not observed when kept for ambient (at room température for 0 days), AHS (at 54±2°C for 14 days) and RT (for 30 months). There was no significant change in the suspensibility of the composition. The composition according to the présent invention remain stable according to the physico-chemical parameters. This signifies that the WDG compositions of flonicamid and WDG compositions of fipronil prepared using disintegration System not only possess excellent stability of the active ingrédients but also retains the dispersibility and hence the availability of the active ingrédients for the intended use. The compositions of Example 1 and Example 6 found to be stable in 30 months real time study which confronts to 2 years shelf life ofthe compositions.
Similarly, the WDG compositions of Example 11 and Example 12 prepared according to the présent invention were investigated for suspensibility, dégradation of active
ingrédient as well as its effect on stability of the composition. The stability study was conducted for ambient (zéro days), AHS (14 days) and RT (12 months). Parameters such as suspensibility, wet sieve analysis and dégradation of active ingrédients were tested for 0 days, 14 days and 12 months respectively. The results are summarized in Table 4.
Table 4
Physico/chemical property Example 11 Example 12
0 days 14 days 12 months 0 days 14 days 12 months
% dégradation Fipronil 0 0.1 0.065 0 0.14 0.14
% dégradation Flonicamid 0 0.12 0.074 0 0.18 0.18
No. of Inversions 11-13 12-14 11-13 13-15 14-15 12-14
Suspensibility 86.20 85.80 86.12 85.40 85.20 85.32
Thus. it can be seen from above table 4 that dégradation of active compounds, fipronil and flonicamid in WDG compositions was not observed when kept even at of 54±2°C for 14 days. Also, the compositions of Example 11 and Example 12 found to remain quite stable with negligible dégradation when kept for real time stability for 12 months. There was no significant change in the suspensibility of the composition.
This signifies that the WDG composition of fipronil and flonicamid so obtained has not only excellent stability of the active ingrédients but also retains the dispersibility and hence the availability of the active ingrédients for the intended use.
In conclusion it is demonstrated that the compositions according to the présent invention remain stable according to the physico-chemical parameters. The combination of actives g and disintegration System in the composition of the présent invention leads to stable WDG composition which does not undergo any Chemical and physical changes on storage and is also easy to handle for further use.

Claims (22)

1. A stable insecticide composition comprising: at least one agrochemical active ingrédient, and a disintegration System,
5 wherein said disintegration System comprises a polymer matrix and an inorganic sait.
2. The stable insecticide composition as claimed in claim 1 wherein said agrochemical active ingrédient is selected from hydrophilic agrochemical active ingrédients and hydrophobie agrochemical active ingrédients.
10
3. The stable insecticide composition as claimed in claim 2 wherein said hydrophilic agrochemical active ingrédients is selected from the group comprising of pyridine organic compounds, triazines, organophosphorous compounds, neonicotinoids, phthalimides, their dérivatives and salts thereof.
4. The stable insecticide composition as claimed in claim 3 wherein said hydrophilic 1 g agrochemical active ingrédients are selected from the group comprising of flonicamid, pymetrozine, acephate, glufosinate, acetamiprid, captan and folpet.
5. The stable insecticide composition as claimed in claim 2 wherein said hydrophobie agrochemical active ingrédients is selected from the group comprising of phenyl pyrazole compound, diamide, triazinone, pyrethroids, 2Q oxadiazine and thiourea class of compounds, their dérivatives and salts thereof.
6. The stable insecticide composition as claimed in claim 5 wherein said hydrophobie agrochemical active ingrédients is selected from the group comprising of fipronil, flubendiamide, metribuzin, indoxacarb, diafenthiuron and bifenthrin.
25
7. The stable insecticide composition as claimed in claim 1 wherein said polymer matrix is selected from the group comprising of polyurea, polyvinyl chloride, polyuréthanes, polyamide, polyvinyl pyrrolidine, acrylic polymers, polyisocyanate-cyclic alkylene, polyamine, polyimine, polycarboxylic acids, naturally occurring polymers, their dérivatives, mixtures and salts thereof.
8. The stable insecticide composition as claimed in claim 1 wherein said polymer matrix of said disintegration System is urea-formaldehyde copolymer.
9. The stable insecticide composition as claimed in claim 1 wherein said inorganic sait is selected from the group of ammonium sulfate, sodium sulfate, ammonium bicarbonate, sodium bicarbonate, magnésium sulfate, hydrogen carbonate, sodium chloride, sodium citrate, ammonium citrate, sodium acetate bentonite, aluminium chloride, citric acid, succinic acid and mixtures thereof.
10. The stable insecticide composition as claimed in claim 1 wherein said inorganic sait is ammonium sulfate.
11. The stable insecticide composition as claimed in claim 1 wherein said disintegration System comprises of polymer matrix and inorganic sait in a ratio from about 1:1 to about 1:4.
12. A stable insecticide composition comprising:
i) at least one hydrophilic agrochemical active ingrédient, ii) at least one hydrophobie agrochemical active ingrédient, and iii)a disintegration System; wherein said disintegration System comprises of a polymer matrix and an inorganic sait.
13 . The stable insecticide composition as claimed in claim 13 wherein said hydrophilic agrochemical active ingrédient is selected from the group comprising of flonicamid, pymetrozine, acephate, glufosinate, acetamiprid, captan and folpet and said hydrophobie agrochemical active ingrédients is selected from the group comprising fipronil, flubendiamide, metribuzin, indoxacarb, diafenthiuron and bifenthnn.
14. The stable insecticide composition as claimed in claim 13 wherein said disintegration system comprises of a polymer matrix and an inorganic sait in a ratio from about 1:1 to about 1:4.
15. A stable insecticide composition comprising:
5 i) flonicamid, ii) fipronil, and iii)a disintegration system; wherein said disintegration system comprises of a polymer matrix and an inorganic sait.
16. A stable insecticide composition comprising:
θ i) diafenthiuron, ii) fipronil and iii) a disintegration system; wherein said disintegration system comprises of a polymer matrix and an inorganic sait.
17. A stable insecticide composition comprising:
15 0 pymetrozine, ii) fipronil, and iii) a disintegration System; wherein said disintegration system comprises of a polymer matrix and an inorganic sait.
18. The composition as claimed in claim 15-17 wherein said disintegration system 2Q comprises of a polymer matrix and an inorganic sait in a ratio from about 1:1 to about 1:4.
19. The composition as claimed in claim 1 wherein said composition is in the form of water dispersible granular formulation.
20. A water dispersible granular formulation comprising:
25 at least one hydrophilic agrochemical active ingrédients selected from the group comprising of pyridine organic compound and organophosphorous compounds; at least one hydrophobie agrochemical active ingrédient selected from tire group comprising of phenyl pyrazole compound, diamide, triazine, pyrethroids, oxadiazine and thiourea class of compounds; and a disintegration System;
5 wherein disintegration System comprises of a polymer matrix and an inorganic sait.
21. A process of preparing stable insecticide composition wherein said process comprising steps of:
i) blending a mixture of agrochemically active ingrédient, a disintegration System comprising a polymer matrix and an inorganic sait, to obtain a blend;
10 ii) grinding the blend to obtain grounded mix; and iii)preparing dough from the homogeneous mixture and perform granulation to obtain granular composition.
22. A method of controlling insects comprising applying to tire pests or to their locus, an effective amount of a stable insecticide composition comprising;
15 at least one hydrophilic agrochemical active ingrédient;
at least one hydrophobie agrochemical active ingrédient; and a disintegration System, wherein disintegration System comprises of a polymer matrix and an inorganic sait in a ratio from about 1:1 to about 1:4.
OA1202100508 2019-05-24 2020-05-23 A stable insecticide composition. OA20402A (en)

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