OA16764A

OA16764A - Composition to be applied to the skin and use thereof.

Info

Publication number: OA16764A
Application number: OA1201400134
Authority: OA
Inventors: Ali Nahavandi
Original assignee: Alnapharm Gmbh & Co. Kg
Priority date: 2011-09-30
Filing date: 2012-09-10
Publication date: 2015-12-14

Abstract

The present invention concerns a composition to be applied to the skin, which comprises a dermatologically compatible vehicle, coconut oil, hazelnut oil and/or avellana oil, and stinging nettle oil, as well as use thereof for the treatment of skin diseases.

Description

l

Composition to be applied to the skin, and use thereof

The présent invention relates to a composition to be applied to the skin, as well as the use thereof in the treatment of skin diseases.

Psoriasis and neurodermatitis (atopie eczema) are very common, chronic, non-contagious, inflammatory skin diseases.

Thus for example around 2 to 3% of the population suffer from the most frequently occurring psoriasis vulgaris, with psoriasis pustolosa being likewîse well-known. Women and men are affected equaliy. Psoriasis is a chronic skin disease, which causes lifelong symptoms. Around one in five psoriasis patients suffer additional arthritic symptoms (psoriasis arthritis) and other chronic inflammatory diseases. Because of the interaction of various clinical pîctures and symptoms, life expectancy can be reduced. For both these diseases, the causes and triggers hâve not yet been conclusively established. Various théories are discussed in the literature. Genetic factors, immunological changes and/or environmental influences are said to play a significant rôle.

External influences can be very diverse. Mechanical, infectious, medication-related, psychological and chronic inflammations are seen as trigger factors.

For psoriasis, one possible explanation for the disease is that the body’s own defence system is disrupted because of immune responses. Here, the production of the T-cells that are responsible for the body’s defence responses proceeds unchecked, whilst T-cell production is however a décisive factor In the régulation of the defence system of the skin. In psoriasis, an uncontrolled antibody defence response develops, and not only are exogenous agents attacked, but also those of the body itself. There is a malfunction in the reproduction of skin cells. Affected skin areas can show severe irritation, reddening, silvery-scaly deposits, and are thickened in places. Some patients hâve cracked skin and open wounds.

In healthy skin, the upper layer of the skin (the epidermis) is renewed at regular intervals. Here, new skin cells are formed, which then âge and become hardened. The hardened skin cells (kératinocytes) are cast off by the body. In the case of a healthy body, this process proceeds almost unnoticed and unseen. In healthy skin, the kératinocytes form a natural protective shield against external environmental influences. The repair mechanism for healthy skin acts via targeted direction of the kératinocyte formation and activation of the T-cells. By contrast, in the case of psoriasis cell growth is disrupted. The formation of skin cells is heavily accelerated, and a disproportionately large number of cells is formed. The increased kératinocyte formation is activated without any outside action, and continues in an uncontrolled manner. A shiny, silverywhite scaly layer forms on the skin. The lower levels of the skin hâve enhanced blood circulation on account of the uncontrolled cell growth, and thus appear severely reddened.

The pathological skin changes (plaques) are frequently distributed individually, in an insular manner. The skin areas most frequently affected are those which are stretched and are subjected to continuai mechanical stress. The skin are as become thickened and form scales. Through the scale formation, the skin becomes hardened and has a tendency towards dryness and wounds.

It is not possible to cure psoriasis. There are many different treatment approaches aimed at soothing the symptoms. The treatments dépend on the severity, location and spread of the lésions. Local and systemie treatments are used, and these can be in the form of préparations or they can be physical. Fundamentally, for initial symptoms and for general care, moisturising skin care products in the form of lotions, creams, oils and ointments are used. If the condition is more advanced, external (topical), internai (systemie) treatments and light are used as forms of treatment. What ail these measures hâve in common is the intention to suppress the scale formation and development of inflammation. The aim is to restore a normal balance of immune response.

However, particularly in the case of systemie therapeutic treatment, it is possible for this to hâve far-reaching effects on the body, and this requires extremely thorough observation and monitoring, since serious complications and side effects can occur.

One task of the présent invention is to provide a composition that is to be applied to the skin, which overcomes the disadvantages of the prior art, and which in particular enables an extremely gentle way of restoring the natural protective function of the skin. The intention here is, in particular, to regenerate the natural barrier function of the skin, and to maintain the processes présent in healthy skin. Here, the composition according to the invention should preferably be capable of being used to support the therapeutic treatment of psoriasis and neurodermatitis.

This problem is solved by a composition to be applied to the skin, which comprises a dermatologically compatible vehicle, coconut oil, hazelnut oil and/or avellana oil, and stinging nettie oil.

It is preferably envisaged here that the weight ratio of dermatologically compatible vehiclexoconut oil : hazelnut oil and/or avellana oil : stinging nettie oil lies within a range of 1-50:1-30:1-50:1-10. Furthermore, it is preferably envisaged that the composition comprises almond oil.

It is preferably envisaged here that the weight ratio of dermatologically compatible vehicle : coconut oil : hazelnut oil and/or avellana oil : stinging nettie oil : almond oil lies within a range of 1-50:130:1-50:1-10:1-20.

Furthermore, it is preferably envisaged that the composition comprises TRF extract (tocotrienol-rich fraction).

It is particularly preferred here that the weight ratio of vehiclexoconut oikhazelnut oil and/or avellana oil : stinging nettle oil :almond oil : TRF extract lies within a range of 1-50:1-30:1-50:110:0-20:1-20.

It can also be envisaged that the composition comprises oil of bïtter almonds.

It is preferably envisaged here that the weight ratio of vehiclexoconut oiLhazelnut oil and/or avellana oil: stinging nettle oil: almond oil: TRF extract: oil of bïtter almonds lies within a range of 150:1-30:1 -50:1 -10:0-20:0-20:1-10.

It is furthermore proposed that the composition comprises natural aromatics, preferably lavender a rom a.

For preference, it is envisaged here that the weight ratio of vehiclexoconut oikhazelnut oil and/or avellana oil: stinging nettle oil: almond oil: TRF extract: oil of bïtter almonds:natural aromatics lies within a range of 1-50:1-30:1-50:1-10:0-20:0-20:0-10:0.1-1.

For particular preference, it is envisaged that the composition comprises:

Dermatologically compatible vehicle

Coconut oil

Hazelnut oil and/o ravellana oil

Stinging nettle oil

Almond oil

TRF extract (tocotrienol-rich fraction)

Oil of bïtter almonds

1-50% by weight, preferably 30-50% by weight, even more preferably 40.00% by weight,

1-30% by weight, preferably 10-30% by weight, even more preferably 15-25% by weight, even more preferably 17.50% by weight,

1-50% by weight, preferably 10-40% by weight, even more preferably 15-35% by weight, even more preferably 20-30% by weight, even more preferably 25.00% by weight,

1-10% by weight, preferably 1-7% by weight, even more preferably 3.00% by weight,

0-20% by weight, preferably 5-15% by weight, even more preferably 10.00% by weight,

0-20% by weight, preferably 1-10% by weight, even more preferably 2-7% by weight, even more preferably 3.00% by weight,

0-10% by weight, preferably 0.5-3% by weight, even more preferably 1.00% by weight,

0-1% by weight, preferably 0.3-0.7% by weight, even more preferably 0.50% by weight,

Aromatics wherein ail the percentages by weight relate to the total quantity of the composition.

If the composition according to the invention contains dermatologically compatible vehicles, coconut oil, hazelnut oil and/or avellana oil, stinging nettle oil and oil of bitter almonds, the weight ratios preferably lie within a range of 1 -50:1-30:1 -50:1-10:1 -10.

It can furthermore be envisaged that it is presented in the form of an ointment, cream, lotion, tincture, oil or gel.

In principle, any dermatologically compatible vehicle that is suitable for the production of ointments, creams, lotions, tinctures, oils or gel scan be used. Experts in the field know of corresponding dermatologically compatibl evehicles.

Here, it can preferably be envisaged that the dermatologically compatible vehicles selected from the groups:

a. Hydrophobie ointments for example comprising: white Vaseline Ph. Eur., yellow Vaseline Ph. Eur, simple ophthalmic ointment DAC

b. Lipophilie gels for example comprising: hydrophobie base gel DAC

c. lipogels for example comprising: lard DAB, white almond oil ointment FH A.4, excipial almond oil ointment

d. water-absorbing ointments W/O absorption ointments for example comprising: wool wax alcohol ointment DAB (Ungt. Alcohol. Lanae), Eucerinum Abhydricum, Ungt. Sorbitansesquioleati, Ungt. Sorbitanmonostearinic, wool wax-free W/O-absorption ointment, Pionier KWH pharma, emulsifying hydrophobie base gel DAC, emulsifying eye ointment (NRF 15.20)

e. O/W absorption ointments for example comprising: hydrophilic ointment DAB, Unguentum Cordes

f. Lipophilie creams for example comprising: lanolin DAB, oily cream (Ungt. Alcoholum Lanae aquosum), Eucerin cum aqua, emollient ointment (Ungt. Molle) DAC, hydrophobie base cream DAC (NRF 11.104), hydrophobie tretinoin cream 0.025/0.05 or 0.1% (NRF 11.123), hydrophobie triclosan cream 2% (NRF 11.122), hydrophobie polidocanol cream 5% (NRF 11.119), hydrophobie polidocanol cream 5% with urea 5% (NRF 11.120), Cremor vaselini MB 59, Cremor sorbitansequioleati, Cremor sorbitanmonostearati,

g. W/O lotions

h. Quasi-W/O creams for example comprising: cold cream (Ungt. Leniens) DAB, cold cream naturel RP

i. Hydrophîlic creams for example comprising: non-ionic hydrophîlic cream DAB, non-ionic hydrophîlic cream SR DAC (NRF S.27), non-ionic aqueous Uniment DAC (NRF 11.92)

j. Hydrophîlic lotions for example comprising: hydrophîlic base émulsion (NRF S.25)

k. Hydrophîlic gels for example comprising: hydroxyethyl cellulose gel DAB

A second problem is solved by the use of the composition for the treatment of skin diseases, in particular psoriasis, neurodermatitis (atopie dermatitis), seborrhoeic dermatitis, urticaria, erythema and lichen planus, as well as for the treatment of wounds / skin burns and corns.

Surprisingly, it was found that the composition according to the invention soothes symptoms associated with skin diseases, such as in particular psoriasis and neurodermatitis. Moreover, the composition according to the invention accelerates the healing of wounds / skin burns as well as corns. In the opinion of the inventors, this takes place on account of physical effects. The composition is based on natural oils as well as a conventional vehicle for the manufacture of the composition, in order to make this suitable for topical application. In combination, the ingrédients hâve a positive effect on the régénération of natural skin functions. The soothing effect is rather achieved through moisturising and caring effects. When applied to the skin, the composition produces a protective film that protects the affected skin areas from external environmental influences and supports the body’s own régénération of skin functions. Through the formation of a protective film, the încreased drying of the lésions is stopped, and the water content in the skin layers can be regenerated. In particular, the water content in the corneum (Stratum corneum) is a décisive factor for healthy skin. The epidermis of healthy skin has natural barrier functions which regulate the water equilibrium, and protect the skin from environmental influences and harmful substances. However, if the skin is affected by psoriasis or neurodermatitis, the natural barrier function is impaired. The composition according to the invention accelerates the restoration of the normal barrier function of the skin. The composition according to the invention protects the skin from harmful environmental influences and substances that trigger allergies. The lipid components contained in the composition according to the invention also produce a cooling effect, resulting in additional soothing.

The effects of the composition according to the invention mean that the skin can regenerate, the formation of the skin’s natural barrier function is supported, and the natural protective barrier function of healthy skin is restored.

Further features and advantages of the composition according to the invention follow from the 5 following detailed description of preferred embodiments.

Example production of a composition as a cream:

Into a dermatologically compatible vehicle, in this case for example Eucerin anhydricum, the components, the oils listed in the composition, are added one after another, whilst stirring, and these are worked into the vehicle. The quantitative ratios of the components resuit from the number 10 of ingrédients and the size of the batch. The quantitative proportions resuit from the desired batch size. The weight quantifies are calculated from the percentages by weight in relation to the batch size.

Depending on the dermatological vehicle used and the number and quantity ratio of the oils used, the resuit is an oily or creamy structure of the composition.

Compositions used in percentages by weight, for testing efficacy:

ό z	Eucerin anhydricum	Coconut oil	Hazelnut oil	Stinging nettle oil	Almond oil	TRF extract	Oil of bitter almonds	Lavender oil
1	40.0	17.5	25.0	3.0	10.0	3.0	1.0	0.5
2	10	13	50	1	1	20	5	0
3	20	30	40	5	5	0	0	0
4	30	6	20	8	15	10	10	1
5	40	10	10	10	20	5	5	0
6	40	27	30	3	0	0	0	0
7	50	5	25	2	15	0	2.5	0.5

The cream compositions listed in the table were used to test efficacy in 49 patients with psoriasis, 33 patients with neurodermatitis as well as 28 patients for the treatment of wounds / skin burns and corns. The creams with the example compositions (see above) were applied 1-3 times a day.

The effect of the compositions on the diseased skin was assessed in 49 patients with psoriasis, at 5 intervals of 1, 5, 10, 20, 30, 45, 60, 75 and 90 days after the beginning of application.

The results of the effect observed are shown in the following table.

Efficacy in the case of psoriasis
Composition no. 1	1 day	5 days	ω >> co TJ o v-	20 days	30 days	45 days	60 days	75 days	90 days
1	44'4	444*	++++	++++	++++	++++	++++	++++	++++
2	+	++	+++	++++	4· 4· 4* 4·	++++	++++	++++	++++
3	+	4*4-4·	+++	+++	+++	+++	++4-4-	4* 4* 4* 4*	4* 4* 4* 4*
4	-/+	+	+	++	++	+++	++++	₊₊₊₊	++++
5	-	-	-/+	+	+4-	4-4-	+++	++++	++++
6	++	+++	++++	++++	++++	++++	++++	++++	++++
7	+	++	+++	+++	+++	+++	++++	++++	++++

Assessment of efficacy:

Poor

-/+ + ++ +++ ++++

The effect of the compositions on the diseased skin was assessed, for 33 patients with neurodermatitis, at intervals of 5, 10, 14, 22, 30, 45, 60, 75 and 90 days after the beginning of application.

The results of the observed effect are shown in the following table.

Efficacy in the case of neurodermatitis
Composition no.	5 days	10 days	14 days	20 days	30 days	45 days	60 days	75 days	90 days
1	+	++	++	+++	+++	+++	++++	++++	₊₊₊₊
2	+	+	+	++	++	+++	+++	++++	++++
3	+	+	+	+	++	+++	+++	++++	++++
4	-/+	-/+	+	++	++	++	+++	++++
5	-	-/+	-/+	+	++	++	+++	+++	++++
6	+	+	++	+++	₊₊₊	++ +	+++	++++	++++
7	-/+	+	+	++	++	+++	+++	++++	++++

Assessment of efficacy:

Poor

-/+ + good

The effect of the compositions on the diseased skin was assessed in 28 patients with wounds / skin burns as well as corns, at intervals of 1, 2, 5, 7, 9, 10 and 14 days after the beginning of application.

The results of the effect observed are shown in the following table.

Wounds / skin burns / corns
Composition no.	1 day	2 days	5 days	7 days	9 days	10 days	14 days
1	++	+++	+++	++++	++++	++++	4* 4* 4* 4*
2	++	++	++	+++	444*	++++	++++
3	++	+++	+++	+++	+++	++++	++++
4	+	+	+	++	++	+++	+++
5	-/+	-/+	-/+	+	4^-	44	+++
6	+4-	+++	++++	₊₊₊₊	++++	4-+4* 4*	+4-4*4-
7	+	+	++	++	+++	4’4’4*	++++

Assessment of efficacy:

Poor < - \jpry good

- -/+ + ++ +++ ++++

From the results for the compositions which are shown above, it can be seen that ail the compositions listed bring about soothing in psoriasis, neurodermatitis and in the treatment of wounds / skin burns as well as corns. The composition that is preferably envisaged has the greatest, most universal and most comprehensive efficacy in ail the envisaged areas of application.

Furthermore, comparison compositions were produced which comprised a dermatologically compatible vehicle (Eucerin anhydricum) and, on the one hand, respectively only hazelnut oil or coconut oil, and on the other hand a mixture of hazelnut oil/coconut oil, and their efficacy in the case of psoriasis patients was observed.

In addition, corresponding trials were carried out based on “vehicle + stinging nettle oil, “vehicle + 15 stinging nettle oil 3% + coconut oil and vehicle + stinging nettle oil 3% + hazelnut oil, and the compositions that were produced were observed in respect of their efficacy in the case of psoriasis patients.

ΙΟ

Finally, a composition according to the invention, of a dermatologicaliy compatible vehicle, coconut oil, hazelnut oil and stinging nettle oil, was produced and likewise investigated.

Dermatologicaliy compatible vehicle + hazelnut oil

A dermatologicaliy compatible vehicle, Eucerin anhydricum, was mixed with hazelnut oil in the proportions shown in the table below, with the percentages being percentages by weight. The mode of action of the composition produced in this way in the treatment of psoriasis was tested. For this, 30 people with mild to moderate psoriasis were treated with this composition over a period of 30 days. In order to enable the treatment to be observed, different vehicle/oil proportions were applied to different areas of skin, and the effect was observed. The results are shown in the following table:

Trial of vehicle + hazelnut oil: Efficacy in the case ofpsoriasis
Oil content in percent	1 day	5 days	10 days	20 days	30 days
10	-	-	-	-/+	+
20	-	-	-/+	-/+	4*
30	-	-/+	-/+	-/+/	+
40	-	-/+	-/+	+	+
50	-	-/+	+	+	+

Assessment of efficacy:

Poor

-/+ + good ++ +++ ++++

Dermatologicaliy compatible vehicle + coconut oil

Analogously to the investigations of a composition of vehicle + hazelnut oil as described above, corresponding investigations were also carried out for a composition of just the vehicle and coconut oil. The results are shown in the following table:

Trial of vehicle + coconut oil: Efficacy in the case of psoriasis
Oil content in percent	1 day	5 days	10 days	20 days	30 days
10	-	-	-	-/+	+
20	-	-	-	-/+	+
30	-	-	-/+	-/+
40	-	-	-/+		+
50	-	-/+	-/+	+	+

Assessment of efficacy:

Poor .i i Jfrry good

-/+ + ++ +++ ++++

Vehicle + hazelnut oil + coconut oil

A composition of vehicle, hazelnut oil and coconut oil was produced, with the two oils being added to the vehicle in equal proportions by weight. The oil proportions given in the table below are calculated from the sum of the individual oil components.

The results are as follows:

Trial of vehicle + hazelnut oil + coconut oil: Efficacy in the case ofpsoriasis
Oil content in percent	1 day	5 days	10 days	20 days	30 days

10	-	-	-	-/+	+
20	-	-	+	+	+
30	-/+	+	4*	++	++
40	-/+	4*	+	++	+++
50	-/+	+	4*	44	+4·+

Assessment of efficacy:

Poor

- -/+ + ++ +++ ++++

Of the compositions tested in this connection, the composition with an oil content of 40% (with the same proportions by weight of hazelnut oil and coconut oil) proved to be the most effective.

Trial of vehicle + stinging nettle oil: Efficacy in the case ofpsorrasis
Oil content in percent	1 day	5 days	10 days	20 days	30 days
1	-	-	-	-/+	+
2	-	-	-/+	+	+
3	-	-/+	+	4·	++
5	-	-/+	+	+	++
10	-	-/+	-/+	+	++

Assessment of efficacy:

Poor ++ +++ ++++

A^ry good

Trial of vehicle + stinging nettle oil 3% + coconut oil: Efficacy in the case of psoriasis
Coconut oil content in percent	1 day	5 days	10 days	20 days	I I ' 30 days I
10	-	-	-/+		++
20	-	-/+	+	+	++
30	-	+	+	++	++
40	-	+	+	++	++
50	-/+	+	+	++	++

Assessment of efficacy:

Poor 4

-/+ + ++ +++ ++++

Trial of vehicle + stinging nettle oil 3% + hazelnut oil: Efficacy in the case of psoriasis
Hazelnut oil content in percent	1 day	5 days	10 days	20 days	30 days
10	-	-/+	-/+	+	+
20	-		+	+	+
30	-/+	+	+	++	++

40	-/+	4*	4*	44	+++
50	-/+	4*	+	++	+++

Assessment of efficacy:

Poor

-/+ — y°T good ++ +++ +++«

Vehicle + hazelnut oil + coconut oil + stinging nettle oil (according to the invention)

Starting out from the composition, described above, with a 40% oil content (equal proportions of hazelnut oil and coconut oil), stinging nettle oil was added to this composition, so that a 10 composition according to the invention was produced.

The following table shows the results for the treatment of psoriasis with the composition according to the invention:

Trial of vehicle + hazelnut oil + coconut oil + stinging nettle oil: Efficacy in the case of psoriasis
Stinging nettle oil content in percent	1 day	5 days	10 days	20 days	30 days
1	4	4*	4-4-	+++	+++
2	4*	44	444*	44+	++++
3	++	+++	++++	++++	++++
5	++	+++	++++	++++	++++
10	++	+++	4++	4* 4* 4* 4*	4* 4* 4* 4*

Assessment of efficacy:

Poor Ifery good

-/+ + ++ +++ ++++

Overall, it is clearly apparent that the composition according to the invention demonstrates clearly improved results in the treatment of psoriasis compared with comparison compositions, after just 30 days. Similar results were also found when the compositions described here were used in the treatment of neurodermatitis or wounds/skin burns/corns.

The features of the invention which are disclosed in the above description and in the claims can be of significance both individually and in any combination for the réalisation of the invention in its 10 individual embodiments.

Claims

Claims

1. Composition to be applied to the skin, comprising a dermatologically compatible vehicle, coconut oil, hazelnut oil and/or avellana oil, and stinging nettle oil.
2. Composition according to claim 1, characterised in that it furthermore comprises TRF extract (tocotrienol-rich fraction).
3. Composition according to claim 1 or 2, characterised in that the percentage ratio of dermatologically compatible vehicle to coconut oil to hazelnut oil and/or avellana oil to stinging nettle oil lies within a range of 1-50:1-30:1-50:1-10.
4. Composition according to one of the preceding claims, characterised in that it furthermore comprises almond oil.
5. Composition according to claim 4, characterised in that the percentage ratio of vehicle to coconut oil to hazelnut oil and/or avellana oil to stinging nettle oil to almond oil lies within a range of 1-50:1-30:1-50:1-10:1-20.
6. Composition according to one of the preceding claims, characterised in that it furthermore comprises oil of bïtter almonds.
7. Composition according to claim 6, characterised in that the weight ratio of vehicle to coconut oil to hazelnut oil and/or avellana oil to stinging nettle oil to almond oil to oil of bitter almonds lies within a range of 1-50:1-30:1-50:1-10:0-20:1-10.
8. Composition according to one of the preceding claims, characterised in that it furthermore comprises natural aromatics, preferably lavender aroma.
9. Composition according to one of the preceding claims, which comprises:

Dermatologically compatible vehicle 1-50% by weight, preferably 30-50% by weight, even more preferably 40.00% by weight,

Coconut oil

1-30% by weight, preferably 10-30% by weight, even more preferably 15-25% by weight, even more preferably17.50% by weight,

Hazelnut oil and/or avellana oil

Stinging nettle oil

1-50% by weight, preferably 10-40% by weight, even more preferably 15-35% by weight, even more preferably 20-30% by weight, even more preferably 25.00% by weight,

1-10% by weight, preferably 1-7% by weight, even more preferably 3.00% by weight,

Almond oil 0-20% by weight, preferably 5-15% by weight, even more preferably 10.00% by weight,

TRF extract (tocotrienol-rich fraction) 0-20% by weight, preferably 1-10% by weight, even more preferably 2-7% by weight, even more preferably 3.00% by weight,

Oil of bitter almonds 0-10% by weight, preferably 0.5-3% by weight, even more preferably 1.00% by weight,

Aromatic substance 0-1% by weight, preferably 0.3-0.7% by weight, even more preferably 0.50% by weight, wherein ail the details of percentages by weight relate to the total quantity of the composition.
10. Composition according to one of the preceding daims, characterised in that it is presented in the form of an ointment, cream, lotion, tincture, oil or gel.
11. Composition according to one of the preceding daims, characterised in that the dermatologically compatible vehicle is selected from the groups of:

a. Hydrophobie ointments

b. Lipophilie gels

c. lipogels

d. water-absorbing ointments W/O absorption ointments

e. O/W absorption ointments

f. Lipophilie creams

g. W/O lotions

h. quasi-W/O creams

i. hydrophilic creams

j. hydrophilic lotions

k. hydrophilic gels
12. Composition according to one of the preceding daims 1 to 11 for use as a médication for the treatment of skin diseases, in particular psoriasis, neurodermatitis, atopie dermatitis, seborrhoeic dermatitis, urticaria, erythema and lichen planus, as well as for the treatment of wounds / skin burns and corns.
13. Use of the composition according to one of the daims 1 to 11 for the treatment of skin diseases, in particular psoriasis, neurodermatitis, atopie demnatitis, seborrhoeic dermatitis, urticaria, erythema and lichen planus, as well as for the treatment of wounds / skin burns and corns.