OA12156A - The genome of the HIV-1 inter-subtype (C/B') and use thereof. - Google Patents
The genome of the HIV-1 inter-subtype (C/B') and use thereof. Download PDFInfo
- Publication number
- OA12156A OA12156A OA1200200146A OA1200200146A OA12156A OA 12156 A OA12156 A OA 12156A OA 1200200146 A OA1200200146 A OA 1200200146A OA 1200200146 A OA1200200146 A OA 1200200146A OA 12156 A OA12156 A OA 12156A
- Authority
- OA
- OAPI
- Prior art keywords
- polynucleotide
- hiv
- sequence
- polypeptide
- nucléotide
- Prior art date
Links
- 241000713772 Human immunodeficiency virus 1 Species 0.000 title description 33
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 57
- 102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 51
- 229920001184 polypeptide Polymers 0.000 claims abstract description 41
- 108091033319 polynucleotide Proteins 0.000 claims abstract description 35
- 102000040430 polynucleotide Human genes 0.000 claims abstract description 35
- 239000002157 polynucleotide Substances 0.000 claims abstract description 35
- 239000012634 fragment Substances 0.000 claims abstract description 31
- 150000007523 nucleic acids Chemical group 0.000 claims abstract description 31
- 229960005486 vaccine Drugs 0.000 claims abstract description 25
- 108091028043 Nucleic acid sequence Proteins 0.000 claims abstract description 23
- 208000031886 HIV Infections Diseases 0.000 claims abstract description 13
- 238000011282 treatment Methods 0.000 claims abstract description 6
- 238000003745 diagnosis Methods 0.000 claims abstract 4
- 150000001413 amino acids Chemical class 0.000 claims description 27
- 210000004027 cell Anatomy 0.000 claims description 18
- 239000000126 substance Substances 0.000 claims description 12
- 108020004414 DNA Proteins 0.000 claims description 11
- 101710091045 Envelope protein Proteins 0.000 claims description 10
- 101710188315 Protein X Proteins 0.000 claims description 10
- 230000001580 bacterial effect Effects 0.000 claims description 8
- 238000004519 manufacturing process Methods 0.000 claims description 8
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims description 7
- 125000006850 spacer group Chemical group 0.000 claims description 6
- 239000013603 viral vector Substances 0.000 claims description 6
- 238000004806 packaging method and process Methods 0.000 claims description 5
- 102000043129 MHC class I family Human genes 0.000 claims description 3
- 108091054437 MHC class I family Proteins 0.000 claims description 3
- 210000003719 b-lymphocyte Anatomy 0.000 claims description 3
- 230000003248 secreting effect Effects 0.000 claims description 3
- 108091054438 MHC class II family Proteins 0.000 claims description 2
- 239000003112 inhibitor Substances 0.000 claims description 2
- 102000043131 MHC class II family Human genes 0.000 claims 1
- 102100021696 Syncytin-1 Human genes 0.000 claims 1
- SGPGESCZOCHFCL-UHFFFAOYSA-N Tilisolol hydrochloride Chemical compound [Cl-].C1=CC=C2C(=O)N(C)C=C(OCC(O)C[NH2+]C(C)(C)C)C2=C1 SGPGESCZOCHFCL-UHFFFAOYSA-N 0.000 claims 1
- 239000003814 drug Substances 0.000 abstract description 7
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 241000700605 Viruses Species 0.000 description 55
- 108090000623 proteins and genes Proteins 0.000 description 37
- 241000725303 Human immunodeficiency virus Species 0.000 description 27
- 235000001014 amino acid Nutrition 0.000 description 26
- 238000002649 immunization Methods 0.000 description 20
- 230000003053 immunization Effects 0.000 description 20
- 235000018102 proteins Nutrition 0.000 description 19
- 102000004169 proteins and genes Human genes 0.000 description 19
- 108091035707 Consensus sequence Proteins 0.000 description 18
- 102100034349 Integrase Human genes 0.000 description 16
- 239000000427 antigen Substances 0.000 description 13
- 108091007433 antigens Proteins 0.000 description 13
- 102000036639 antigens Human genes 0.000 description 13
- 125000003275 alpha amino acid group Chemical group 0.000 description 12
- 238000004458 analytical method Methods 0.000 description 12
- 239000002245 particle Substances 0.000 description 11
- 238000005215 recombination Methods 0.000 description 11
- 230000006798 recombination Effects 0.000 description 11
- 239000013598 vector Substances 0.000 description 11
- 210000004989 spleen cell Anatomy 0.000 description 10
- 108091026890 Coding region Proteins 0.000 description 9
- 230000014509 gene expression Effects 0.000 description 9
- 108700004028 nef Genes Proteins 0.000 description 9
- 101710149951 Protein Tat Proteins 0.000 description 8
- 108010027225 gag-pol Fusion Proteins Proteins 0.000 description 8
- 238000000034 method Methods 0.000 description 8
- 101150023385 nef gene Proteins 0.000 description 8
- 230000001225 therapeutic effect Effects 0.000 description 8
- 238000012512 characterization method Methods 0.000 description 7
- 238000000338 in vitro Methods 0.000 description 7
- 102000039446 nucleic acids Human genes 0.000 description 7
- 108020004707 nucleic acids Proteins 0.000 description 7
- 230000003612 virological effect Effects 0.000 description 7
- 208000030507 AIDS Diseases 0.000 description 6
- 108010041986 DNA Vaccines Proteins 0.000 description 6
- 229940021995 DNA vaccine Drugs 0.000 description 6
- 241000699670 Mus sp. Species 0.000 description 6
- 108010092799 RNA-directed DNA polymerase Proteins 0.000 description 6
- 238000004113 cell culture Methods 0.000 description 6
- 239000003153 chemical reaction reagent Substances 0.000 description 6
- 238000009396 hybridization Methods 0.000 description 6
- 208000015181 infectious disease Diseases 0.000 description 6
- 230000021633 leukocyte mediated immunity Effects 0.000 description 6
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 description 6
- 239000013612 plasmid Substances 0.000 description 6
- 230000022532 regulation of transcription, DNA-dependent Effects 0.000 description 6
- 108700026244 Open Reading Frames Proteins 0.000 description 5
- 238000011161 development Methods 0.000 description 5
- 229940079593 drug Drugs 0.000 description 5
- 238000007920 subcutaneous administration Methods 0.000 description 5
- 238000013518 transcription Methods 0.000 description 5
- 230000035897 transcription Effects 0.000 description 5
- 108090000695 Cytokines Proteins 0.000 description 4
- 102000004127 Cytokines Human genes 0.000 description 4
- 108091081024 Start codon Proteins 0.000 description 4
- 101800001690 Transmembrane protein gp41 Proteins 0.000 description 4
- 101710201961 Virion infectivity factor Proteins 0.000 description 4
- 210000000612 antigen-presenting cell Anatomy 0.000 description 4
- 230000002238 attenuated effect Effects 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- 238000010367 cloning Methods 0.000 description 4
- 238000002856 computational phylogenetic analysis Methods 0.000 description 4
- 239000003623 enhancer Substances 0.000 description 4
- 230000028993 immune response Effects 0.000 description 4
- 230000006698 induction Effects 0.000 description 4
- 230000001939 inductive effect Effects 0.000 description 4
- 238000007918 intramuscular administration Methods 0.000 description 4
- 238000005304 joining Methods 0.000 description 4
- 210000004962 mammalian cell Anatomy 0.000 description 4
- 108700026222 vpu Genes Proteins 0.000 description 4
- 108020004705 Codon Proteins 0.000 description 3
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 3
- 108091034117 Oligonucleotide Proteins 0.000 description 3
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 230000003321 amplification Effects 0.000 description 3
- 230000000890 antigenic effect Effects 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 230000001413 cellular effect Effects 0.000 description 3
- 210000000805 cytoplasm Anatomy 0.000 description 3
- 230000001472 cytotoxic effect Effects 0.000 description 3
- 238000009826 distribution Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 108700004025 env Genes Proteins 0.000 description 3
- 101150030339 env gene Proteins 0.000 description 3
- 230000002068 genetic effect Effects 0.000 description 3
- 230000028996 humoral immune response Effects 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 238000003780 insertion Methods 0.000 description 3
- 230000037431 insertion Effects 0.000 description 3
- 238000002955 isolation Methods 0.000 description 3
- 230000003472 neutralizing effect Effects 0.000 description 3
- 238000003199 nucleic acid amplification method Methods 0.000 description 3
- 230000004044 response Effects 0.000 description 3
- 238000007894 restriction fragment length polymorphism technique Methods 0.000 description 3
- 238000002864 sequence alignment Methods 0.000 description 3
- 238000003786 synthesis reaction Methods 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 238000013519 translation Methods 0.000 description 3
- 230000032258 transport Effects 0.000 description 3
- 241001430294 unidentified retrovirus Species 0.000 description 3
- 108700026215 vpr Genes Proteins 0.000 description 3
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 2
- 241000710929 Alphavirus Species 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- 101710132601 Capsid protein Proteins 0.000 description 2
- 108700010070 Codon Usage Proteins 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 2
- ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 description 2
- 101710177291 Gag polyprotein Proteins 0.000 description 2
- 239000004471 Glycine Substances 0.000 description 2
- 229940033330 HIV vaccine Drugs 0.000 description 2
- 241000560067 HIV-1 group M Species 0.000 description 2
- 108090000978 Interleukin-4 Proteins 0.000 description 2
- 108010002616 Interleukin-5 Proteins 0.000 description 2
- JVTAAEKCZFNVCJ-REOHCLBHSA-N L-lactic acid Chemical compound C[C@H](O)C(O)=O JVTAAEKCZFNVCJ-REOHCLBHSA-N 0.000 description 2
- 101710125418 Major capsid protein Proteins 0.000 description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- 108010047620 Phytohemagglutinins Proteins 0.000 description 2
- 238000012300 Sequence Analysis Methods 0.000 description 2
- 101710172711 Structural protein Proteins 0.000 description 2
- 108700019146 Transgenes Proteins 0.000 description 2
- 241000700618 Vaccinia virus Species 0.000 description 2
- 206010046865 Vaccinia virus infection Diseases 0.000 description 2
- 108010003533 Viral Envelope Proteins Proteins 0.000 description 2
- 230000005875 antibody response Effects 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000000234 capsid Anatomy 0.000 description 2
- 125000002091 cationic group Chemical group 0.000 description 2
- 239000003086 colorant Substances 0.000 description 2
- 230000001186 cumulative effect Effects 0.000 description 2
- 230000001086 cytosolic effect Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000001747 exhibiting effect Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 230000037433 frameshift Effects 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 230000001900 immune effect Effects 0.000 description 2
- 210000000987 immune system Anatomy 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 238000010348 incorporation Methods 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- 230000001885 phytohemagglutinin Effects 0.000 description 2
- 238000003752 polymerase chain reaction Methods 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 230000009257 reactivity Effects 0.000 description 2
- 108020003175 receptors Proteins 0.000 description 2
- 102000005962 receptors Human genes 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 238000012163 sequencing technique Methods 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 241000701161 unidentified adenovirus Species 0.000 description 2
- 241000712461 unidentified influenza virus Species 0.000 description 2
- 238000011144 upstream manufacturing Methods 0.000 description 2
- 208000007089 vaccinia Diseases 0.000 description 2
- 101150090490 vpu gene Proteins 0.000 description 2
- NHBKXEKEPDILRR-UHFFFAOYSA-N 2,3-bis(butanoylsulfanyl)propyl butanoate Chemical compound CCCC(=O)OCC(SC(=O)CCC)CSC(=O)CCC NHBKXEKEPDILRR-UHFFFAOYSA-N 0.000 description 1
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
- 241001212582 Ancara Species 0.000 description 1
- 241000271566 Aves Species 0.000 description 1
- 238000011725 BALB/c mouse Methods 0.000 description 1
- 108010041397 CD4 Antigens Proteins 0.000 description 1
- 210000003359 CD4-positive helper T lymphocyte Anatomy 0.000 description 1
- 108090000565 Capsid Proteins Proteins 0.000 description 1
- 102000014914 Carrier Proteins Human genes 0.000 description 1
- 108010078791 Carrier Proteins Proteins 0.000 description 1
- 102000053642 Catalytic RNA Human genes 0.000 description 1
- 108090000994 Catalytic RNA Proteins 0.000 description 1
- 239000004971 Cross linker Substances 0.000 description 1
- 238000000018 DNA microarray Methods 0.000 description 1
- 238000001712 DNA sequencing Methods 0.000 description 1
- 238000002965 ELISA Methods 0.000 description 1
- 102100038132 Endogenous retrovirus group K member 6 Pro protein Human genes 0.000 description 1
- 108700024394 Exon Proteins 0.000 description 1
- 108010087819 Fc receptors Proteins 0.000 description 1
- 102000009109 Fc receptors Human genes 0.000 description 1
- 229920001917 Ficoll Polymers 0.000 description 1
- 208000000666 Fowlpox Diseases 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 101710168592 Gag-Pol polyprotein Proteins 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 208000037357 HIV infectious disease Diseases 0.000 description 1
- 108700010908 HIV-1 proteins Proteins 0.000 description 1
- 229940033332 HIV-1 vaccine Drugs 0.000 description 1
- 108091005904 Hemoglobin subunit beta Proteins 0.000 description 1
- 108091027305 Heteroduplex Proteins 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 108010048209 Human Immunodeficiency Virus Proteins Proteins 0.000 description 1
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 1
- 108010061833 Integrases Proteins 0.000 description 1
- 102100037850 Interferon gamma Human genes 0.000 description 1
- 108010074328 Interferon-gamma Proteins 0.000 description 1
- 108010002350 Interleukin-2 Proteins 0.000 description 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
- 239000000232 Lipid Bilayer Substances 0.000 description 1
- 241000701076 Macacine alphaherpesvirus 1 Species 0.000 description 1
- 108010052285 Membrane Proteins Proteins 0.000 description 1
- 102000018697 Membrane Proteins Human genes 0.000 description 1
- 108010085220 Multiprotein Complexes Proteins 0.000 description 1
- 102000007474 Multiprotein Complexes Human genes 0.000 description 1
- 241001529936 Murinae Species 0.000 description 1
- 108090001074 Nucleocapsid Proteins Proteins 0.000 description 1
- 108010038807 Oligopeptides Proteins 0.000 description 1
- 102000015636 Oligopeptides Human genes 0.000 description 1
- 108010058846 Ovalbumin Proteins 0.000 description 1
- 241001631646 Papillomaviridae Species 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 108091000080 Phosphotransferase Proteins 0.000 description 1
- 108010076039 Polyproteins Proteins 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 108010076504 Protein Sorting Signals Proteins 0.000 description 1
- 241001092473 Quillaja Species 0.000 description 1
- 235000009001 Quillaja saponaria Nutrition 0.000 description 1
- 230000006819 RNA synthesis Effects 0.000 description 1
- 108700005075 Regulator Genes Proteins 0.000 description 1
- 238000012952 Resampling Methods 0.000 description 1
- 108091028664 Ribonucleotide Proteins 0.000 description 1
- 241000714474 Rous sarcoma virus Species 0.000 description 1
- 241000710961 Semliki Forest virus Species 0.000 description 1
- 241000700584 Simplexvirus Species 0.000 description 1
- 241000713675 Spumavirus Species 0.000 description 1
- 108010008038 Synthetic Vaccines Proteins 0.000 description 1
- 230000024932 T cell mediated immunity Effects 0.000 description 1
- 108091008874 T cell receptors Proteins 0.000 description 1
- 230000005867 T cell response Effects 0.000 description 1
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 description 1
- 210000001744 T-lymphocyte Anatomy 0.000 description 1
- 108020005038 Terminator Codon Proteins 0.000 description 1
- 241000711975 Vesicular stomatitis virus Species 0.000 description 1
- 108010067390 Viral Proteins Proteins 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 235000004279 alanine Nutrition 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 239000004411 aluminium Substances 0.000 description 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
- 229910021502 aluminium hydroxide Inorganic materials 0.000 description 1
- 229960000723 ampicillin Drugs 0.000 description 1
- AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 description 1
- 230000000692 anti-sense effect Effects 0.000 description 1
- -1 antisense constructs Proteins 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 238000003149 assay kit Methods 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 230000001588 bifunctional effect Effects 0.000 description 1
- 244000309464 bull Species 0.000 description 1
- 238000004422 calculation algorithm Methods 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 230000034303 cell budding Effects 0.000 description 1
- 230000005101 cell tropism Effects 0.000 description 1
- 239000013599 cloning vector Substances 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- CVSVTCORWBXHQV-UHFFFAOYSA-N creatine Chemical compound NC(=[NH2+])N(C)CC([O-])=O CVSVTCORWBXHQV-UHFFFAOYSA-N 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 230000005574 cross-species transmission Effects 0.000 description 1
- 108091092330 cytoplasmic RNA Proteins 0.000 description 1
- 231100000433 cytotoxic Toxicity 0.000 description 1
- 230000007402 cytotoxic response Effects 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 231100000517 death Toxicity 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- 210000004443 dendritic cell Anatomy 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000009510 drug design Methods 0.000 description 1
- 206010014599 encephalitis Diseases 0.000 description 1
- 210000003527 eukaryotic cell Anatomy 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 239000013604 expression vector Substances 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 239000007850 fluorescent dye Substances 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 238000012239 gene modification Methods 0.000 description 1
- 238000001415 gene therapy Methods 0.000 description 1
- 102000054766 genetic haplotypes Human genes 0.000 description 1
- 230000005017 genetic modification Effects 0.000 description 1
- 238000010448 genetic screening Methods 0.000 description 1
- 235000013617 genetically modified food Nutrition 0.000 description 1
- 238000003205 genotyping method Methods 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 230000013595 glycosylation Effects 0.000 description 1
- 238000006206 glycosylation reaction Methods 0.000 description 1
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 125000005842 heteroatom Chemical group 0.000 description 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 description 1
- 230000008105 immune reaction Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000002163 immunogen Effects 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 239000000411 inducer Substances 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 229930027917 kanamycin Natural products 0.000 description 1
- 229960000318 kanamycin Drugs 0.000 description 1
- SBUJHOSQTJFQJX-NOAMYHISSA-N kanamycin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N SBUJHOSQTJFQJX-NOAMYHISSA-N 0.000 description 1
- 229930182823 kanamycin A Natural products 0.000 description 1
- 210000003292 kidney cell Anatomy 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 238000013507 mapping Methods 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 201000006512 mast cell neoplasm Diseases 0.000 description 1
- 208000006971 mastocytoma Diseases 0.000 description 1
- 239000011859 microparticle Substances 0.000 description 1
- 239000004005 microsphere Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 238000010369 molecular cloning Methods 0.000 description 1
- 210000001616 monocyte Anatomy 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 238000007857 nested PCR Methods 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 229940092253 ovalbumin Drugs 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 230000026731 phosphorylation Effects 0.000 description 1
- 238000006366 phosphorylation reaction Methods 0.000 description 1
- 238000013081 phylogenetic analysis Methods 0.000 description 1
- 239000013600 plasmid vector Substances 0.000 description 1
- 230000008488 polyadenylation Effects 0.000 description 1
- 108700007863 polyomavirus VP1 Proteins 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 230000037452 priming Effects 0.000 description 1
- 230000001566 pro-viral effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000008707 rearrangement Effects 0.000 description 1
- 229940124551 recombinant vaccine Drugs 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 230000000284 resting effect Effects 0.000 description 1
- 108091008146 restriction endonucleases Proteins 0.000 description 1
- 230000001177 retroviral effect Effects 0.000 description 1
- 239000002336 ribonucleotide Substances 0.000 description 1
- 125000002652 ribonucleotide group Chemical group 0.000 description 1
- 210000003705 ribosome Anatomy 0.000 description 1
- 108091092562 ribozyme Proteins 0.000 description 1
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 description 1
- 238000012289 standard assay Methods 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 108700004027 tat Genes Proteins 0.000 description 1
- 101150098170 tat gene Proteins 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 229940021747 therapeutic vaccine Drugs 0.000 description 1
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 description 1
- 230000005758 transcription activity Effects 0.000 description 1
- 238000010361 transduction Methods 0.000 description 1
- 230000026683 transduction Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 238000003146 transient transfection Methods 0.000 description 1
- 108091005703 transmembrane proteins Proteins 0.000 description 1
- 102000035160 transmembrane proteins Human genes 0.000 description 1
- 241001529453 unidentified herpesvirus Species 0.000 description 1
- 238000002255 vaccination Methods 0.000 description 1
- 239000012646 vaccine adjuvant Substances 0.000 description 1
- 229940124931 vaccine adjuvant Drugs 0.000 description 1
- 108700026220 vif Genes Proteins 0.000 description 1
- 101150059019 vif gene Proteins 0.000 description 1
- 239000000277 virosome Substances 0.000 description 1
- 101150024249 vpr gene Proteins 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 210000005253 yeast cell Anatomy 0.000 description 1
- 108700041090 yeast p1 Proteins 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16211—Human Immunodeficiency Virus, HIV concerning HIV gagpol
- C12N2740/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16311—Human Immunodeficiency Virus, HIV concerning HIV regulatory proteins
- C12N2740/16322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19955089 | 1999-11-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| OA12156A true OA12156A (en) | 2006-05-08 |
Family
ID=7929215
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| OA1200200146A OA12156A (en) | 1999-11-16 | 2000-11-16 | The genome of the HIV-1 inter-subtype (C/B') and use thereof. |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US7332588B1 (xx) |
| EP (1) | EP1240333B1 (xx) |
| CN (2) | CN101586106B (xx) |
| AP (1) | AP1674A (xx) |
| AT (1) | ATE391785T1 (xx) |
| AU (1) | AU784635B2 (xx) |
| BR (1) | BR0015607A (xx) |
| CA (1) | CA2391560A1 (xx) |
| DE (2) | DE10056747A1 (xx) |
| ES (1) | ES2303513T3 (xx) |
| HK (1) | HK1046428A1 (xx) |
| OA (1) | OA12156A (xx) |
| WO (1) | WO2001036614A2 (xx) |
| ZA (1) | ZA200204047B (xx) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6582920B2 (en) | 2000-09-01 | 2003-06-24 | Gen-Probe Incorporated | Amplification of HIV-1 RT sequences for detection of sequences associated with drug-resistance mutations |
| JP4601956B2 (ja) * | 2001-09-20 | 2010-12-22 | グラクソ グループ リミテッド | Ｈｉｖ−ｇａｇのコドン最適化ｄｎａワクチン |
| ES2281252B1 (es) * | 2005-07-27 | 2009-02-16 | Consejo Superior De Investigaciones Cientificas | Vectores recombinantes basados en el virus modificado de ankara (mva) como vacunas preventivas y terapeuticas contra el sida. |
| BRPI0504117A (pt) | 2005-09-05 | 2007-05-22 | Fundacao De Amparo A Pesquisa | epìtopos, combinação de epìtopos, usos de epìtopos ou sua combinação, composição, usos da composição, vacinas profiláticas anti-hiv-1, vacinas terapêuticas, método para a identificação de epìtopos e métodos para o tratamento ou prevenção |
| EP2023954B1 (en) * | 2006-05-19 | 2013-07-17 | Sanofi Pasteur, Inc. | Immunological composition |
| WO2010127115A1 (en) | 2009-04-30 | 2010-11-04 | Centre Hospitalier Universitaire Vaudois Lausanne (Chuv) | Modified immunization vectors |
| EP2542703A4 (en) * | 2010-03-02 | 2013-10-23 | Int Aids Vaccine Initiative | NEW HIV-1 ENVELOPE GLYCOPROTEIN |
| US20150190501A1 (en) | 2011-09-12 | 2015-07-09 | Imperial Innovations Limited | Methods and compositions for raising an immune response to hiv |
| WO2015073291A1 (en) * | 2013-11-14 | 2015-05-21 | The Trustees Of The University Of Pennsylvania | Hiv-1 env dna vaccine plus protein boost |
| CN105586319B (zh) * | 2014-10-20 | 2021-01-08 | 中国疾病预防控制中心性病艾滋病预防控制中心 | 复制型痘苗病毒载体艾滋病疫苗 |
| CN107090019B (zh) * | 2017-01-23 | 2018-11-23 | 张帅 | 人类免疫缺陷病毒重组蛋白 |
| CN110627911B (zh) * | 2019-10-14 | 2022-11-22 | 吉林大学 | 一种可诱导hiv-1广谱中和抗体的包膜蛋白三聚体免疫原及用途 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5215913A (en) | 1987-11-30 | 1993-06-01 | Roger Williams General Hospital | IgG-1 human monoclonal antibody reactive with an HIV-1 antigen and methods of use |
| ATE208813T1 (de) | 1988-02-16 | 2001-11-15 | Greatbatch Gen Aid Ltd | Modifizierte zellen mit resistenz gegen retroviralinfektionen |
| US5580761A (en) | 1988-02-16 | 1996-12-03 | Greatbatch Gen-Aid Ltd. | Method of conferring resistance to immunodeficiency viral infection |
| ATE120234T1 (de) | 1988-06-09 | 1995-04-15 | Innogenetics Nv | Hiv-3-retrovirus und seine verwendung. |
| DE68928082T2 (de) * | 1988-08-31 | 1998-01-15 | Aprogenex Inc | Manuelles in situ hybridisierungsverfahren |
| ATE112687T1 (de) | 1988-09-13 | 1994-10-15 | Chiron Corp | Mutanten des hiv-1 hüllproteins mit fehlenden hypervariabelen domänen. |
| ATE125157T1 (de) | 1990-04-03 | 1995-08-15 | Genentech Inc | Methoden und zusammensetzungen zur impfung gegen hiv. |
| WO1992006199A2 (fr) | 1990-09-27 | 1992-04-16 | Institut Pasteur | Peptides inducteurs d'anticorps inhibant des retrovirus du type hiv et anticorps diriges contre ces peptides |
| US5847096A (en) | 1991-08-30 | 1998-12-08 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | DNA constructs encoding CD4 fusion proteins |
| WO1995011998A1 (en) | 1993-10-26 | 1995-05-04 | United Biomedical, Inc. | Structured synthetic antigen libraries as diagnostics, vaccines and therapeutics |
| AU1372495A (en) | 1993-12-13 | 1995-07-03 | United Biomedical Inc. | Specific hyperimmune anti-hiv globulin for passive immunization |
| US5599662A (en) * | 1995-02-17 | 1997-02-04 | Hoffmann-La Roche Inc. | Oliconucleotide primers and probes for the detection of HIV-1 |
| DE19513152A1 (de) | 1995-04-07 | 1996-10-10 | Bundesrep Deutschland | Verwendung eines "Immundefizienzvirus-supprimierenden Lymphokins (ISL)" zur Hemmung der Virusvermehrung, insbesondere von Retroviren |
| GB9510272D0 (en) | 1995-05-22 | 1995-07-19 | Isis Innovation | Retroviral vectors |
| GB9621679D0 (en) | 1996-10-17 | 1996-12-11 | Oxford Biomedica Ltd | Improved retroviral vectors |
| GB9803351D0 (en) * | 1998-02-17 | 1998-04-15 | Oxford Biomedica Ltd | Anti-viral vectors |
| US6958226B1 (en) * | 1998-09-11 | 2005-10-25 | The Children's Medical Center Corp. | Packaging cells comprising codon-optimized gagpol sequences and lacking lentiviral accessory proteins |
| JP2003523721A (ja) | 1998-12-31 | 2003-08-12 | カイロン コーポレイション | 抗原性ｈｉｖｃ型ポリペプチドをコードするポリヌクレオチド、ポリペプチド、およびそれらの使用 |
| JP2002533124A (ja) * | 1998-12-31 | 2002-10-08 | カイロン コーポレイション | Ｈｉｖポリペプチドの改善された発現およびウイルス様粒子の生成 |
| AU778809B2 (en) * | 1999-03-29 | 2004-12-23 | Statens Serum Institut | Method for producing a nucleotide sequence construct with optimised codons for an HIV genetic vaccine based on primary, early HIV isolate and synthetic envelope BX08 constructs |
-
2000
- 2000-11-16 AP APAP/P/2002/002508A patent/AP1674A/en active
- 2000-11-16 CN CN200910127667.7A patent/CN101586106B/zh not_active Expired - Lifetime
- 2000-11-16 EP EP00987164A patent/EP1240333B1/de not_active Expired - Lifetime
- 2000-11-16 CN CN00818426A patent/CN1423698A/zh active Pending
- 2000-11-16 ES ES00987164T patent/ES2303513T3/es not_active Expired - Lifetime
- 2000-11-16 WO PCT/DE2000/004073 patent/WO2001036614A2/de active IP Right Grant
- 2000-11-16 DE DE10056747A patent/DE10056747A1/de not_active Withdrawn
- 2000-11-16 AT AT00987164T patent/ATE391785T1/de active
- 2000-11-16 AU AU23504/01A patent/AU784635B2/en not_active Ceased
- 2000-11-16 CA CA002391560A patent/CA2391560A1/en not_active Abandoned
- 2000-11-16 US US10/130,157 patent/US7332588B1/en not_active Expired - Lifetime
- 2000-11-16 DE DE50015096T patent/DE50015096D1/de not_active Expired - Lifetime
- 2000-11-16 BR BR0015607-8A patent/BR0015607A/pt not_active Application Discontinuation
- 2000-11-16 OA OA1200200146A patent/OA12156A/en unknown
-
2002
- 2002-05-22 ZA ZA200204047A patent/ZA200204047B/xx unknown
- 2002-10-21 HK HK02107615A patent/HK1046428A1/xx not_active IP Right Cessation
-
2006
- 2006-05-19 US US11/438,134 patent/US7323557B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE50015096D1 (de) | 2008-05-21 |
| CA2391560A1 (en) | 2001-05-25 |
| CN1423698A (zh) | 2003-06-11 |
| EP1240333A2 (de) | 2002-09-18 |
| ES2303513T3 (es) | 2008-08-16 |
| US7323557B2 (en) | 2008-01-29 |
| DE10056747A1 (de) | 2001-05-31 |
| AP1674A (en) | 2006-10-30 |
| CN101586106A (zh) | 2009-11-25 |
| AU2350401A (en) | 2001-05-30 |
| AP2002002508A0 (en) | 2002-06-30 |
| BR0015607A (pt) | 2002-07-30 |
| ZA200204047B (en) | 2002-12-20 |
| WO2001036614A3 (de) | 2002-02-28 |
| US7332588B1 (en) | 2008-02-19 |
| ATE391785T1 (de) | 2008-04-15 |
| HK1046428A1 (en) | 2003-01-10 |
| EP1240333B1 (de) | 2008-04-09 |
| WO2001036614A2 (de) | 2001-05-25 |
| CN101586106B (zh) | 2015-04-01 |
| US20070003572A1 (en) | 2007-01-04 |
| AU784635B2 (en) | 2006-05-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US7323557B2 (en) | Genome of the HIV-1 inter-subtype (C/B') and use thereof | |
| JP6165612B2 (ja) | コンセンサス／先祖免疫原 | |
| Doria-Rose et al. | Human immunodeficiency virus type 1 subtype B ancestral envelope protein is functional and elicits neutralizing antibodies in rabbits similar to those elicited by a circulating subtype B envelope | |
| Cho et al. | Polyvalent envelope glycoprotein vaccine elicits a broader neutralizing antibody response but is unable to provide sterilizing protection against heterologous simian/human immunodeficiency virus infection in pigtailed macaques | |
| JP5033303B2 (ja) | 抗原性ｃ型ｈｉｖポリペプチドをコードするポリヌクレオチド、ポリペプチドおよびそれらの使用 | |
| US7169396B2 (en) | Reference clones and sequences for non-subtype B isolates of human immunodeficiency virus type 1 | |
| US8586056B2 (en) | HIV-1 envelope glycoprotein | |
| WO2006038908A2 (en) | Ancestral and cot viral sequences, proteins and immunogenic compositions | |
| Burgers et al. | Design and preclinical evaluation of a multigene human immunodeficiency virus type 1 subtype C DNA vaccine for clinical trial | |
| JP2009082136A (ja) | 抗原性ｂ型ｈｉｖポリペプチドおよび／または抗原性ｃ型ｈｉｖポリペプチドをコードするポリヌクレオチド、それらのポリペプチドおよびそれらの使用 | |
| AU3567797A (en) | Hiv envelope polypeptides and vaccine | |
| JP2013146270A (ja) | 抗原性ｂ型ｈｉｖポリペプチドをコードするポリヌクレオチド、そのポリペプチドおよびそれらの使用 | |
| EP1814583A2 (en) | Combination approaches for generating immune responses | |
| Casimiro et al. | Vaccine-induced immune responses in rodents and nonhuman primates by use of a humanized human immunodeficiency virus type 1 pol gene | |
| Verrier et al. | A human immunodeficiency virus prime-boost immunization regimen in humans induces antibodies that show interclade cross-reactivity and neutralize several X4-, R5-, and dualtropic clade B and C primary isolates | |
| US20070166784A1 (en) | Combination approaches for generating immune responses | |
| US20040115621A1 (en) | Ancestral viruses and vaccines | |
| Robert-Guroff et al. | Alteration of V3 loop context within the envelope of human immunodeficiency virus type 1 enhances neutralization | |
| US6521739B1 (en) | Complete genome sequence of a simian immunodeficiency virus from a red-capped mangabey | |
| ZA200603029B (en) | Combination approaches for generating immune responses |