OA09299A - Nouveaux dérivés N- (vincristinoyl-23) et N- (noranhydro-5' vinblastinoyl-23) d'acide animo-1 méthylphosphonique, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. - Google Patents
Nouveaux dérivés N- (vincristinoyl-23) et N- (noranhydro-5' vinblastinoyl-23) d'acide animo-1 méthylphosphonique, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.Info
- Publication number
- OA09299A OA09299A OA59827A OA59827A OA09299A OA 09299 A OA09299 A OA 09299A OA 59827 A OA59827 A OA 59827A OA 59827 A OA59827 A OA 59827A OA 09299 A OA09299 A OA 09299A
- Authority
- OA
- OAPI
- Prior art keywords
- radical
- carbon atoms
- denotes
- linear
- hydrogen atom
- Prior art date
Links
- YACKEPLHDIMKIO-UHFFFAOYSA-N methylphosphonic acid Chemical compound CP(O)(O)=O YACKEPLHDIMKIO-UHFFFAOYSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- -1 alkyl radical Chemical class 0.000 abstract 8
- 125000004432 carbon atom Chemical group C* 0.000 abstract 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- TUJKJAMUKRIRHC-UHFFFAOYSA-N hydroxyl Chemical compound [OH] TUJKJAMUKRIRHC-UHFFFAOYSA-N 0.000 abstract 2
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical compound [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- CFHIDWOYWUOIHU-UHFFFAOYSA-N oxomethyl Chemical compound O=[CH] CFHIDWOYWUOIHU-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8910554A FR2651348B1 (es) | 1989-08-04 | 1989-08-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| OA09299A true OA09299A (fr) | 1992-09-15 |
Family
ID=9384495
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| OA59827A OA09299A (fr) | 1989-08-04 | 1990-08-03 | Nouveaux dérivés N- (vincristinoyl-23) et N- (noranhydro-5' vinblastinoyl-23) d'acide animo-1 méthylphosphonique, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5100881A (es) |
| EP (1) | EP0412015B1 (es) |
| JP (1) | JPH075619B2 (es) |
| AT (1) | ATE109485T1 (es) |
| AU (1) | AU625885B2 (es) |
| CA (1) | CA2022538C (es) |
| DE (1) | DE69011235T2 (es) |
| DK (1) | DK0412015T3 (es) |
| ES (1) | ES2060979T3 (es) |
| FR (1) | FR2651348B1 (es) |
| IE (1) | IE66007B1 (es) |
| NZ (1) | NZ234771A (es) |
| OA (1) | OA09299A (es) |
| PT (1) | PT94906B (es) |
| ZA (1) | ZA905924B (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5508463A (en) * | 1994-03-17 | 1996-04-16 | Trustees Of The University Of Pennsylvania | α-aminophosphonates |
| CA2385528C (en) | 1999-10-01 | 2013-12-10 | Immunogen, Inc. | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3354163A (en) * | 1966-12-15 | 1967-11-21 | Eli Lillty And Company | Nu-desmethylvinblastine |
| HU165986B (es) * | 1973-02-16 | 1974-12-28 | ||
| US4307100A (en) * | 1978-08-24 | 1981-12-22 | Agence Nationale De Valorisation De La Recherche (Anvar) | Nor bis-indole compounds usable as medicaments |
| US4210584A (en) * | 1979-01-15 | 1980-07-01 | Eli Lilly And Company | Vindesine synthesis |
| LU84640A1 (fr) * | 1983-02-10 | 1984-11-08 | Onmichem S A | Nouveau procede d'obtention de la vincristine et du sulfate de vincristine |
| US4619935A (en) * | 1983-03-17 | 1986-10-28 | Eli Lilly And Company | Stable oncolytic formulations |
| US4522750A (en) * | 1984-02-21 | 1985-06-11 | Eli Lilly And Company | Cytotoxic compositions of transferrin coupled to vinca alkaloids |
| FR2623504B1 (fr) * | 1987-11-25 | 1990-03-09 | Adir | Nouveaux derives n-(vinblastinoyl-23) d'acide amino-1 methylphosphonique, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent |
| US4923876A (en) * | 1988-04-18 | 1990-05-08 | Cetus Corporation | Vinca alkaloid pharmaceutical compositions |
-
1989
- 1989-08-04 FR FR8910554A patent/FR2651348B1/fr not_active Expired - Fee Related
-
1990
- 1990-07-27 ZA ZA905924A patent/ZA905924B/xx unknown
- 1990-08-01 US US07/561,065 patent/US5100881A/en not_active Expired - Fee Related
- 1990-08-02 CA CA002022538A patent/CA2022538C/fr not_active Expired - Fee Related
- 1990-08-03 DK DK90402226.6T patent/DK0412015T3/da active
- 1990-08-03 PT PT94906A patent/PT94906B/pt not_active IP Right Cessation
- 1990-08-03 AU AU60149/90A patent/AU625885B2/en not_active Ceased
- 1990-08-03 OA OA59827A patent/OA09299A/xx unknown
- 1990-08-03 JP JP2206668A patent/JPH075619B2/ja not_active Expired - Lifetime
- 1990-08-03 ES ES90402226T patent/ES2060979T3/es not_active Expired - Lifetime
- 1990-08-03 AT AT90402226T patent/ATE109485T1/de active
- 1990-08-03 NZ NZ234771A patent/NZ234771A/en unknown
- 1990-08-03 EP EP90402226A patent/EP0412015B1/fr not_active Expired - Lifetime
- 1990-08-03 DE DE69011235T patent/DE69011235T2/de not_active Expired - Fee Related
- 1990-08-03 IE IE280890A patent/IE66007B1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| PT94906B (pt) | 1997-03-31 |
| FR2651348A1 (es) | 1991-03-01 |
| DK0412015T3 (da) | 1994-11-28 |
| DE69011235T2 (de) | 1995-03-09 |
| IE66007B1 (en) | 1995-11-29 |
| AU6014990A (en) | 1991-02-07 |
| FR2651348B1 (es) | 1993-01-22 |
| CA2022538C (fr) | 1996-09-24 |
| IE902808A1 (en) | 1991-02-27 |
| JPH075619B2 (ja) | 1995-01-25 |
| JPH03118388A (ja) | 1991-05-20 |
| US5100881A (en) | 1992-03-31 |
| DE69011235D1 (de) | 1994-09-08 |
| ES2060979T3 (es) | 1994-12-01 |
| PT94906A (pt) | 1991-04-18 |
| EP0412015A1 (fr) | 1991-02-06 |
| EP0412015B1 (fr) | 1994-08-03 |
| AU625885B2 (en) | 1992-07-16 |
| NZ234771A (en) | 1992-05-26 |
| CA2022538A1 (fr) | 1991-02-05 |
| ATE109485T1 (de) | 1994-08-15 |
| ZA905924B (en) | 1991-05-29 |
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