NZ787184A - Articles and formulations for smoking products and vaporizers - Google Patents

Abstract

A vaporizer cartridge comprising at least 5 mg of very low THC cannabis, at least 5 mg of low nicotine tobacco and flavorants in a vented compartment, where the THC cannabis comprises a collective THCA/THC content of equal to or less than 3 mg/g, and wherein the low nicotine tobacco comprises a nicotine content of equal to or less than 3 mg/g. This allow for the customization of tobacco and cannabis smoking products for harm reduction and different flavours.

Description

ARTICLES AND FORMULATIONS FOR SMOKING PRODUCTS AND VAPORIZERS CROSS REFERENCE TO RELATED APPLICATIONS This application claims priority from U.S. Patent Application No. ,318, filed on September 12, 2019, in the U.S. Patent and ark Office, the disclosure of which is incorporated herein by reference in its entirety.

BACKGROUND 1. Field The present disclosure relates to tobacco and cannabis products. 2. Description of the Related Art Tobacco product manufacturers possess the methods and knowhow to produce products with a wide range of nicotine content and alkaloid es. For example, they can produce cigarettes ranging from approximately 0.20 mg per cigarette of nicotine to at least 30 mg per cigarette. Very low nicotine cigarettes and low tar-to-nicotine yield-ratio cigarettes are both useful for o harm reduction for different purposes; the former is to quit smoking and o use altogether or transition s to smokeless tobacco products, and the latter is to smoke less. The s and knowhow of tobacco product manufacturers include genetic engineering and plant breeding techniques to decrease or increase nicotine content in tobacco plants. Nicotine can also be extracted from tobacco for production of very low nicotine cigarettes or nicotine can be added for production of low tar-to-nicotine yield-ratio cigarettes. See, for example, U.S. Patents 3,612,066, 622, 9,814,258 and 10,113,174, which describe these methods ed by o product manufacturers to produce factory-made tobacco products. o end users, on the other hand, do not possess these method or knowhow capabilities; nor have they had devices or the alkaloids in the appropriate formulations to conveniently and economically add alkaloids, inoids, flavors, or other additives to their smoking products, which include cigarettes, cigars and marijuana ttes.

Some people smoke or vape tobacco and cannabis simultaneously, including those who do not otherwise smoke tobacco, since there are ocal and fortifying effects from the combination of the nicotine in tobacco and the cannabinoids in cannabis. Inhaling smoke or vapor is the most efficient and quickest way of encing the effects of these compounds, whether tobacco or cannabis is smoked or vaped separately or simultaneously. The main issue with smoking or vaping a blend of tobacco and cannabis is that many non-nicotine and noncannabinoid compounds must be inhaled along with the nicotine and cannabinoids. This is especially the case when smoking a blend of tobacco and cannabis or g cigarettes with any added cannabinoids since in either case, many carcinogenic tobacco compounds must be d concurrently with the nicotine and cannabinoids. Michael Russell, referred to as the father of tobacco harm reduction, famously declared, "People smoke for nicotine but they die from the tar." However, using tobacco in any form, ing in smokeless tobacco products, is not without risk since tobacco contains tobacco-specific nitrosamines (TSNAs), which are carcinogenic, and include osonornicotine (NNN), 4-N-Nitrosomethylamino(3-pyridyl)butanone (NNK), N-Nitrosoanatabine (NAT), and N-Nitrosoanabasine (NAB). U.S. Patent 10,369,178 discloses tobacco products with added cannabinoids; however, this disclosure in no way solves the m of s being d to many tobacco carcinogens including TSNAs in order to enjoy the pleasurable effects of consuming nicotine and cannabinoids simultaneously. Nor does the disclosure propose any device that facilitates consumers modifying their factory-made cigarettes.

Accordingly, there is a need for products comprising appropriate formulations which enable consumers to (i) conveniently, ically, and precisely customize the nicotine, other alkaloid, and/or flavoring content of their factory-made smoking products and (ii) enjoy the pleasurable combined effects of nicotine, cannabinoids and combinations of other compounds through ready-to-vape and ready-to-smoke precision pods without exposure to other tobacco compounds.

According to an embodiment of the disclosure, there is provided an onsert to apply onto, around, or within a smoking product for transferring one or more compounds to mainstream smoke of the smoking product, the onsert ing a osic wrapper, an adhesive disposed on the cellulosic wrapper for adhering the onsert to the g product, and one or more compounds disposed on the cellulosic wrapper, the one or more compounds individually equaling at least 1 mg selected from the group consisting of nicotine, anatabine, anabasine, flavor, Δ9- tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA), cannabichromenenic acid (CBCA), cannabigerolic acid (CBGA), tetrahydrocanabivarinic acid (THCVA), cannabidivarinic acid (CBDVA), cannabichromevarinic acid (CBCVA), cannabigerovarinic acid (CBGVA), myrcene, caryophyllene, pinene, limonene and ne.

For the , the smoking product may be a cigarette, and the one or more compounds may be ne.

In the onsert, the nicotine may e a ne salt.

For the , the smoking product may be a cigarette, and the one or more compounds may be anatabine.

For the onsert, the smoking product may be a cigarette, and the one or more compounds may be Δ9-tetrahydrocannabinolic acid (THCA).

For the onsert, the smoking product may be a cigarette, and the one or more compounds may be cannabidiolic acid (CBDA).

For the onsert, the smoking product may be a cigarette, and the one or more compounds may be Δ9-tetrahydrocannabinolic acid (THCA) and cannabidiolic acid (CBDA) collectively equaling at least 5 mg.

For the onsert, the smoking product may be tobacco, and the one or more compounds may be ne.

For the , the smoking product may be tobacco, and the one or more compounds may be anatabine.

For the , the smoking t may be tobacco, and the one or more compounds may be Δ9-tetrahydrocannabinolic acid (THCA).

For the onsert, the smoking product may be tobacco, and the one or more compounds may be cannabidiolic acid (CBDA).

For the onsert, the smoking product may be cannabis, and the one or more compounds may be nicotine.

For the onsert, the g product may be cannabis, and the one or more compounds may be anatabine.

For the onsert, the smoking product may be cannabis, and the one or more compounds may be Δ9-tetrahydrocannabinolic acid (THCA).

For the onsert, the smoking product may be cannabis, and the one or more compounds may be CBDA.

For the onsert, the smoking product may be is, and the one or more compounds may be THCA and CBDA collectively equaling at least 5 mg.

For the onsert, the g product may be a marijuana cigarette, and the one or more compounds may be nicotine.

For the onsert, the smoking product may be a ana cigarette, and the one or more compounds may be anatabine.

In the , the adhesive may be self-sticking.

In the onsert, the adhesive may be moisture activated.

According to an embodiment of the disclosure, there is provided a precision rod for insertion into a smoking product to er one or more compounds to mainstream smoke of the smoking product, the precision rod including one or more compounds individually equaling at least 1 mg selected from the group consisting of nicotine, ine, anabasine, flavor, Δ9- tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA), cannabichromenenic acid (CBCA), cannabigerolic acid (CBGA), ydrocanabivarinic acid ), cannabidivarinic acid (CBDVA), cannabichromevarinic acid (CBCVA), cannabigerovarinic acid ), myrcene, caryophyllene, pinene, limonene and humulene, and a cellulosic rod having an ignition temperature of less than 350 degrees Celsius to which the one or more compounds may be adhered to or housed within the cellulosic rod.

For the precision rod, the smoking product may be a cigarette, and the one or more compounds may be nicotine.

In the precision rod, the nicotine may be a nicotine salt.

For the precision rod, the g product may be a cigarette, and the one or more compounds may be Δ9-tetrahydrocannabinolic acid (THCA).

For the ion rod, the smoking product may be a cigarette, and the one or more compounds may be cannabidiolic acid (CBDA).

For the precision rod, the smoking product may be a cigarette, and the one or more compounds may be Δ9-tetrahydrocannabinolic acid (THCA) and cannabidiolic acid (CBDA) collectively equaling at least 5 mg.

For the precision rod, the smoking product may be a marijuana cigarette, and the one or more nds may be ne.

For the precision rod, the smoking product may be a cigarette, and the one or more compounds may be anatabine. ing to an embodiment of the disclosure, there is provided a precision rod for insertion into a smoking product to transfer one or more compounds to mainstream smoke of the smoking product, the precision rod including one or more compounds individually equaling at least 1 mg ed from the group consisting of nicotine, anatabine, anabasine, flavor, Δ9- tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA), cannabichromenenic acid (CBCA), cannabigerolic acid (CBGA), tetrahydrocanabivarinic acid (THCVA), cannabidivarinic acid (CBDVA), cannabichromevarinic acid (CBCVA), cannabigerovarinic acid (CBGVA), myrcene, caryophyllene, , ne and ne, an inner chamber that houses the one or more compounds, a flame-resistant rigid material around the inner chamber having an on temperature of more than 350 degrees Celsius in which the one or more compounds may be disposed, and at least one vent for ventilation of inbound air into the precision rod and outbound smoke out of the precision rod.

For the precision rod, the g product may be a cigarette and, the one or more compounds may be nicotine.

In the precision rod, the nicotine may be a nicotine salt.

For the precision rod, the smoking product may be a cigarette, and the one or more compounds may be Δ9-tetrahydrocannabinolic acid (THCA).

For the precision rod, the smoking product may be a cigarette, and the one or more compounds may be cannabidiolic acid (CBDA).

For the precision rod, the smoking t may be a cigarette, and the one or more compounds may be Δ9-tetrahydrocannabinolic acid (THCA) and idiolic acid (CBDA).

For the precision rod, the smoking product may be a marijuana cigarette, and the one or more compounds may be nicotine.

According to an embodiment of the disclosure, there is provided a ready-to-vape precision pod for use with a zer configured to generate vapor from dry herbs or concentrated plant extracts for the simultaneous inhalation of two or more compounds, the ready-to-vape precision pod including each of two or more blended compounds equaling at least 1 mg selected from the group consisting of nicotine, anatabine, ine, flavor, Δ9-tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA), cannabichromenenic acid (CBCA), cannabigerolic acid , tetrahydrocanabivarinic acid ), cannabidivarinic acid (CBDVA), cannabichromevarinic acid ), cannabigerovarinic acid (CBGVA), myrcene, caryophyllene, pinene, limonene and humulene, a compartment that houses the two or more blended compounds, and one or more vents for ventilation of inbound air into the compartment and outbound vapor out of the compartment, wherein the to-vape precision pod may be configured for ent into an oven chamber of the vaporizer.

In the ready-to-vape precision rod, the two or more blended compounds may be nicotine and Δ9-tetrahydrocannabinolic acid (THCA).

In the ready-to-vape precision rod, the nicotine may be a nicotine salt.

In the to-vape precision rod, the two or more blended compounds may be nicotine, Δ9-tetrahydrocannabinolic acid (THCA), and Cannabidiolic acid (CBDA).

In the ready-to-vape precision rod, the two or more blended compounds may be nicotine, Δ9-tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA), and cannabichromenenic acid (CBCA).

In the ready-to-vape ion rod, the two or more blended compounds may be nicotine and anatabine.

In the ready-to-vape precision rod, the two or more d compounds may be anatabine and Δ9-tetrahydrocannabinolic acid .

In the ready-to-vape precision rod, the two or more blended compounds may be anatabine and cannabidiolic acid (CBDA).

In the ready-to-vape precision rod, the two or more blended compounds may be anatabine, rahydrocannabinolic acid (THCA), and cannabidiolic acid (CBDA).

According to an embodiment of the disclosure, there is provided a ready-to-vape precision pod for use with a vaporizer, the ready-to-vape ion pod including one or more compounds equaling at least 1 mg selected from the group consisting of nicotine, anatabine, anabasine, flavor, Δ9-tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA), cannabichromenenic acid (CBCA), cannabigerolic acid (CBGA), tetrahydrocanabivarinic acid (THCVA), cannabidivarinic acid (CBDVA), ichromevarinic acid (CBCVA), cannabigerovarinic acid (CBGVA), myrcene, caryophyllene, pinene, limonene and humulene, marijuana ng at least 5 mg, a compartment that houses the one or more compounds and the marijuana, and one or more vents for ation of inbound air into the tment and outbound vapor out of the compartment, wherein the ready-to-vape precision pod may be configured for placement into an oven chamber of the vaporizer.

In the ready-to-vape precision rod, the one or more compounds may be nicotine.

In the ready-to-vape precision rod, the one or more compounds may be Tetrahydrocanabivarinic acid (THCVA).

In the ready-to-vape precision rod, the one or more compounds may be Δ9- tetrahydrocannabinolic acid (THCA).

According to an embodiment of the disclosure, there is provided a flavor injection system for infusing one or more compounds into a smoking product to transfer the one or more compounds to mainstream smoke of the smoking product, the flavor injection system including a plunger mechanism, a precision rod for insertion into the smoking product, and one or more compounds dually ng at least 1 mg selected from the group consisting of nicotine, anatabine, anabasine, flavor, Δ9-tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA), cannabichromenenic acid (CBCA), cannabigerolic acid (CBGA), cannabigerovarinic acid (CBGVA), ydrocanabivarinic acid (THCVA), cannabidivarinic acid (CBDVA), ichromevarinic acid (CBCVA), myrcene, caryophyllene, pinene, limonene and humulene, n the plunger mechanism is ted to the precision rod, wherein the precision rod comprises one or more holes and an inner chamber that houses the one or more compounds, and wherein the plunger is configured to infuse the mainstream smoke of the smoking product with the one or more compounds by g the compounds through the one or more holes in the precision rod into the mainstream smoke of the smoking product.

According to an embodiment of the disclosure, there is provided a method of increasing the nicotine smoke yield of a factory-made cigarette, the method including providing an onsert including a salt of nicotine, wherein the onsert may be for ion into the factory-made cigarette.

According to an embodiment of the disclosure, there is provided a method of increasing nicotine smoke yield of a factory-made cigarette, the method including ing a precision rod including a salt of nicotine, wherein the precision rod may be for insertion into the factory-made cigarette.

According to an ment of the disclosure, there is provided a nicotineenhanced cigarette including a cigarette and an adjunct source of nicotine ted to or inserted into the cigarette, wherein the adjunct source of nicotine increases the nicotine yield of the cigarette by at least 10 percent.

The adjunct source of nicotine may be an onsert connected to the cigarette.

The adjunct source of nicotine may be a precision rod inserted into the cigarette.

According to an embodiment of the disclosure, there is provided a ready-to-smoke precision pod for use with a smoking t for the simultaneous inhalation of two or more compounds, the ready-to-smoke precision pod including each of two or more blended compounds equaling at least 1 mg selected from the group consisting of nicotine, anatabine, anabasine, flavor, Δ9-tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA), cannabichromenenic acid (CBCA), cannabigerolic acid (CBGA), tetrahydrocanabivarinic acid (THCVA), cannabidivarinic acid (CBDVA), cannabichromevarinic acid (CBCVA), cannabigerovarinic acid (CBGVA), e, caryophyllene, pinene, ne and humulene, a tment that houses the two or more blended compounds, and one or more vents for ventilation of d air into the compartment and outbound smoke out of the compartment, wherein the smoking product includes a pipe, bowl or bong, and wherein the ready-to-smoke ion pod may be configured for placement into a chamber of the smoking product.

In the to-smoke precision pod, the two or more blended compounds may be nicotine and Δ9-tetrahydrocannabinolic acid (THCA).

In the ready-to-smoke precision pod, the nicotine may be a ne salt.

In the ready-to-smoke precision pod, the two or more blended compounds may be nicotine, Δ9-tetrahydrocannabinolic acid (THCA), and idiolic acid .

In the ready-to-smoke precision pod, the two or more blended compounds may be nicotine, rahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA), and Cannabichromenenic acid (CBCA).

In the ready-to-smoke precision pod, the two or more blended compounds may be a nicotine salt and anatabine.

In the to-smoke precision pod, the two or more blended compounds may be anatabine and Δ9-tetrahydrocannabinolic acid (THCA).

In the ready-to-smoke precision pod, the two or more blended compounds may be anatabine and cannabidiolic acid (CBDA).

In the ready-to-smoke precision pod, the two or more blended compounds may be anatabine, Δ9-tetrahydrocannabinolic acid (THCA), and cannabidiolic acid (CBDA).

According to an embodiment of the disclosure, there is provided a ready-to-smoke precision pod for use with a smoking product, the ready-to-smoke precision pod including one or more compounds ng at least 1 mg selected from the group consisting of nicotine, anatabine, ine, flavor, Δ9-tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA), cannabichromenenic acid (CBCA), cannabigerolic acid (CBGA), tetrahydrocanabivarinic acid (THCVA), cannabidivarinic acid (CBDVA), cannabichromevarinic acid (CBCVA), cannabigerovarinic acid (CBGVA), myrcene, caryophyllene, pinene, limonene and ne, very low ne tobacco equaling at least 5 mg, a compartment that houses the one or more nds and the very low nicotine tobacco, and one or more vents for ventilation of d air into the compartment and outbound smoke out of the compartment, wherein the smoking product includes a pipe, bowl, or bong, wherein the very low nicotine tobacco includes less than 3 mg/g nicotine, and wherein the ready-to-smoke precision pod may be configured for ent into a r of the smoking product.

In the ready-to-smoke precision pod, the one or more compounds may be anatabine.

In the ready-to-smoke precision pod, the one or more compounds may be cannabidiolic acid (CBDA).

BRIEF DESCRIPTION OF THE DRAWINGS The above and/or other aspects of the present disclosure will be more apparent by describing certain embodiments of the present disclosure with reference to the accompanying drawings, in which: is a top view of an exemplary embodiment of a self-stick onsert for a cigarette; is a perspective view of the self-stick onsert of partially wrapped around the cigarette; is a top view of the self-stick onsert of FIGS. 1A and 1B fully wrapped around and stuck to the tte; is a top view of two ary ments of self-stick onserts; is a top view of an exemplary embodiment of self-stick onserts; is a top view of an exemplary embodiment of a self-stick onsert; is a front exploded view of an exemplary embodiment of a precision rod and a view of this precision rod led; is a ctive view of exemplary embodiments of precision rods, each with varying size; is a top view of an exemplary embodiment of a ion rod inserted into a cigarette; is a perspective view of an exemplary embodiment of a flavor injection system; is a ctive view of an ary embodiment of a ready-to-smoke precision pod for a bowl or pipe; is a is a perspective view of the ready-to-smoke precision pod of that has been placed in a smoking product, namely a bowl; is a perspective view of a prior art vaporizer being held in which the oven cover has been removed exposing the oven chamber; and is a perspective view of an exemplary embodiment of a ready-to-vape precision pod placed within the oven chamber of the prior art vaporizer of .

DETAILED DESCRIPTION OF THE EMBODIMENTS Devices and formulations disclosed herein allow tobacco and is end users to conveniently, economically and precisely customize the content of nicotine, cannabinoids, flavoring and/or other ves in the ream smoke from their smoking products such as cigarettes and in the mainstream vapor from their vaporizers to meet preferred product and taste ences regardless of manufacturers’ product offerings in a given market. Very low nicotine cigarettes are an important tool for transitioning smokers to e-cigarettes or tobacco heating products and for smokers ng tobacco and nicotine products altogether; therefore, very low nicotine cigarettes, along with e-cigarettes and tobacco heating products, have great potential for tobacco harm reduction. Since the rate of metabolizing nicotine varies widely across different populations of smokers, consumers having the ability, for example, to slightly increase the nicotine content of their own very low nicotine cigarettes is important. Devices and formulations sed herein r consumers to modify the compounds in the smoke from smoking products and the precisely customize the compounds in vapor from vaporizers to their preferences.

Regarding very low nicotine cigarettes, these cations allow a greater percentage of s to tolerate these cigarettes and exclusively smoke them (without smoking any conventional cigarettes) while ting to quit tobacco and nicotine products altogether or switch to a less harmful product such as e-cigarettes or ready-to-vape precision pods comprising unique blends of nds. See U.S. Patent Application No. 16/047,948 for methods and various types of very low nicotine cigarettes and other products to assist smokers in transitioning to e-cigarettes or a tobacco heating device or to assist smokers in quitting o and nicotine altogether.

In a phase III clinical trial published in The Journal of the American l Association to determine if there is a difference in biomarkers of smoke re between reducing the nicotine content of cigarettes immediately versus gradually, the immediate reduction in nicotine caused greater withdrawal ms, r use of non-study conventional cigarettes, and higher dropout rates. For these study subjects, the immediate ion to very low nicotine cigarettes containing tobacco with 0.4 mg nicotine per gram (nicotine content per cigarette is imately 0.3 mg) was likely too low of a nicotine reduction too quickly. See JAMA September 4, 2018, Volume 320, Number 9, pages 880-891. Some of these subjects who dropped out of this study (and other studies using very low nicotine cigarettes) would likely have completed the study if they had access to a device which easily connected to their very low nicotine cigarettes and provided an adjunct source of ne transferred to mainstream smoke, as needed by the smoker. Mainstream smoke is the smoke that is inhaled and es the smoke that emerges from a smoker’s mouth or that emerges from the mouth end of a smoking product (e.g., filter end of a filtered cigarette) as a result of a smoker smoking the smoking product. The amount of nicotine provided for this purpose would be quite low.

In a phase II clinical trial to examine the effects of reduced nicotine cigarettes on smoking behavior, toxicant exposure, dependence and abstinence, there were three interventions: six weeks of (i) 0.05 mg ne yield cigarettes (very low nicotine content cigarette), (ii) 0.3 mg nicotine yield cigarettes (low nicotine content cigarette with approximately 6-fold the ne content of the very low nicotine cigarette), and (iii) a 4 mg nicotine lozenge. Although dropout rates were highest for the nicotine lozenge arm at 48 percent, dropout rates for the 0.05 mg nicotine yield cigarette arm was second highest at 40%, ed by 25 percent for the 0.3 mg nicotine yield cigarette arm. Dropouts were considered treatment failures so reducing the dropout rate among those using the very low nicotine cigarette would have been beneficial since the very low nicotine cigarette arm had the highest abstinence rate post treatment among the 3 interventions. See Hatsukami et al. 2010, Addiction, 105(2):343-55. If tho se in the very low nicotine cigarette arm of the study had access to a product which easily connected to their very low nicotine cigarettes to ly increase nicotine in mainstream smoke, as needed, the dropout rate would likely have been less and the cessation rate .

For smokers not interested in quitting or switching to a smokeless product, increasing the nicotine content of conventional cigarettes, which results in low tar-to-nicotine yield-ratio cigarettes and sed smoke inhalation due to the sed concentration of nicotine. Since cigarettes which have a low tar-to-nicotine yield ratio (‘tar’ e yield divided by nicotine machine yield which may be an ISO method or other ) of approximately 8 or less are not currently sold by tobacco companies, consumers enhancing the nicotine yield of their y-made conventional cigarettes is advantageous for those who desire to reduce their harm from smoking but cannot quit smoking cigarettes or will not quit smoking cigarettes.

Conventional cigarettes typically have a tar-to-nicotine yield ratio from 10 to 14 (e.g., ISO ‘tar’ yield of 13 mg and nicotine yield of 1mg), which means in this example, for every 1 ram of nicotine, a smoker must inhale about 13 milligrams ‘tar.’ It is important to note that although people smoke for nicotine, smoking d e results from the smoke including ‘tar.’ Reducing the dose of smoke reduces harm.

[Link] http://www.lsro.org/presentation_files/rrrvw/cc_2005_10_19/pandolfino.pdf [Link] http://www.lsro.org/presentation_files/rrrvw/cc_2005_10_19/pandolfino.pdf Due to compensatory smoking behaviors, as compared to conventional ttes, exposure to harmful "tar" and gases is decreased with nicotine-enhanced ttes (as defined below) while exposure to nicotine remains imately the same. Although there is variation, smokers generally desire approximately 1 mg of nicotine per cigarette, and any more nicotine per cigarette than what a smoker desires s an unpleasant experience. Smokers easily titrate down their smoke re when smoking nicotine-enhanced ttes by taking r puffs and fewer puffs per cigarette. Conventional cigarettes in which the nicotine yield has been enhanced in the mainstream smoke by embodiments herein, allow smokers to obtain this approximate 1 mg of nicotine per cigarette (or any other per cigarette amount a smoker finds acceptable) more efficiently and smokers inhale less smoke, as compared to conventional cigarettes in which the nicotine yield has not been enhanced. See, for example, Armitage et al. 1998, Psychopharmacology, 96:447-453; trom 1982, Pharmacology, 77:164-167; Russell M.A., Nicotine and Public Health, Chapter 15, American Public Health Organization, 2000; and Pandolfino 2005, Presentation on October 19, 2005 at Life Science Research Organization (LSRO), Reducing the Adverse Health Impact of Cigarettes on Smokers Who Will Not or Cannot Abstain Through Modification of Leaf Nicotine Content, which may be aded at the LSRO website.

A conventional tte that has a tar-to-nicotine yield ratio of 13, which now includes a sufficient adjunct nicotine source (e.g., a precision rod comprising 18 mg of nicotine inserted into a tte), results in a ne-enhanced cigarette with a tar-to-nicotine yield ratio of less than eight. The result is that smokers inhale significantly less smoke including less ‘tar.’ The exact tar-to-nicotine yield ratio depends on the features of the cigarette being enhanced including overall ventilation, type of filter, level of additives, et cetera.

There are s reasons manufacturers do not make certain products available to consumers (e.g., low tar-to-nicotine yield-ratio cigarettes of ≤ 8) even though there is demand.

These include corporate decisions to not cannibalize sales of existing products on the market, lack of technology or intellectual property, high cost or limited availability of raw materials, law or regulations prohibiting manufacturers from selling a product (but not consumers from making or modifying a factory-made product), and/or the level of demand in a market may not justify the large capital expenditures required to bring a product to market (e.g., ed machinery).

Each of the terms ‘about’ or ‘approximately’ is used herein to mean roughly, around, nearly, or in the region of. When the term ‘about’ or ‘approximately’ is used in ction with a numerical value or range, it modifies that value or range by reasonably extending the boundaries above and below the numerical values set forth.

"Alkaloids" are a group of nitrogenous compounds typically of plant origin. For example, nicotine is the primary alkaloid found in commercialized cigarette tobacco accounting for, depending on tobacco type (e.g., flue cured, burley and oriental) and variety (e.g., K326), about 95 percent of the total alkaloids in tobacco leaf. Anatabine, otine, anabasine and other alkaloids t for the remaining n of total ids. The alkaloid profile, which is the percentage or contribution of each alkaloid to the total content of all alkaloids, differs across tobacco types, tobacco varieties and cigarette brand fillers. Depending on tobacco type and variety, anatabine ts for about 1% to about 4%, nornicotine accounts for about 1% to about 3%, and anabasine accounts for about 0.02% to about 0.4%. As used herein ‘nicotine,’ ‘anatabine’ and ‘anabasine’ may be extracted from any plant s including any species of the genus Nicotiana, and any of these alkaloids may also be synthesized, or be an analog, or be made in the form of salts of c acids. See, e.g., Sisson et al 1990, Beitragezur Tabakforschung ational, Volume 14, No. 6, June-July. Synthetic ne, nicotine salts derived from synthetic nicotine, synthetic anatabine, anatabine salts derived from tic anatabine, synthetic anabasine, anabasine salts derived from synthetic anabasine, analogs of ne, analogs of anatabine, analogs of anabasine, nicotine salts of organic acids, anatabine salts of organic acids, and anabasine salts of organic acids are included herein in the meaning of nicotine, anatabine and anabasine, respectively. Nicotine salts, nicotine co-crystals, and nicotine salt co-crystals are all included in the meaning of nicotine herein and any of these including combination may be used in any embodiment herein.

Although nicotine is a hygroscopic oily liquid which may be utilized in the embodiments herein in that form, end users enhancing the delivery of nicotine in finished tobacco products with ne as a solid or semi-solid is preferred for the embodiments herein due to increased stability and cleaner and easier applications for end users, as compared to liquid forms of ne. See, for example, U.S. Patent No. 9,738,622, which ses nicotine salts, nicotine co-crystals and nicotine salt co-crystals that are in a solid or semi-solid form, but does not disclose methods or s for consumers to incorporate these as an t source of nicotine to finished tobacco ts or smoking products such as y-made cigarettes. Liquid forms of nicotine such as e-liquids or e-juice would inhibit the ignition and burning of smoking products to produce smoke, and the ne content is too diluted to be a significant and ive adjunct nicotine source. Besides being too voluminous for the embodiments herein, these liquid and dilute forms of nicotine would defeat the purpose of some of the aerosol embodiments herein for vaporizers since too much aerosol would be required to be ted for a given dose of nicotine. Whether smoke or vapor, the less inhaled the better, which is an advantage of concentrating nicotine and cannabinoids in the embodiments herein.

In addition to solid or semi-solid forms of nicotine, other compounds utilized in the ations herein for onserts, precision rods, and precision pods are preferably in a solid or semi-solid form. A solid, of course, is a fundamental and ly referred to state of matter (others are liquid, gas and plasma). A semi-solid is the physical term fo r something whose state lies between a solid and a liquid. A semi-solid material is similar to a solid in some characteristics such as the ability to support its own weight and to hold its own shape. Examples of semi-solids are peanut butter, toothpaste and petroleum jelly. Blends of compounds and components for formulations in, on or within onserts, precision rods or precision pods may include solids, semisolids and liquids; however, the final blended formulation is preferably a solid or semi-solid (not a liquid such as an e-liquid). For example, a blend of ingredients in the compartment of a precision pod may include a lline ne salt, a wax of concentrated cannabis, and liquid glycerin resulting in the final blended formulation being a solid or semi-solid (which depends on proportions of each of the 3 ients used) even though a liquid was ed (to add an appropriate level of moisture).

A nicotine salt is a form of nicotine characterized by the interaction between nicotine in ionic form and a coformer in ionic form such as an acid by the transfer of one or more protons from the coformer donor to the nicotine acceptor. The structure of ne has two en atoms capable of accepting protons from a er so it can be present in nonprotonated , mono-protonated or di-protonated form. Examples of nicotine salts include but are not limited to the following: nicotine 4-acetamidobenzoate, nicotine ascorbate, nicotine aspartate, ne benzoic, nicotine bitartrate, nicotine chloride such as ne dihydrochloride and nicotine hydrochloride, nicotine citrate, nicotine 2,3-dihydroxybenzoate, ne 3,5- dihydroxybenzoate, nicotine fumarate, nicotine gentisate (2,5-hydroxybenzoic), nicotine ate, nicotine l-hydroxynaphthoate, nicotine 3-hydroxybenzoate, nicotine lactate, nicotine levulinic, nicotine malate, ne mono-pyruvate, nicotine mucate, nicotine perchlorate, nicotine pyruvate, nicotine salicylate, nicotine succinate, nicotine sulfate, nicotine tartrate and nicotine zinc chloride.

A nicotine stal is a form of ne encompassing nicotine and at least one other component (coformer) in which both are in neutral form. Co-crystals are usually characterized by a crystalline structure, which is generally held together by freely reversible, noncovalent interactions. Co-crystals are typically made up of nicotine and at least one other component in a defined stoichiometric ratio and can include hydrates, solvates and clathrates. Cocrystals can comprise nicotine in combination with an organic and/or an inorganic ent and are generally distinguished from salts by the absence of a proton transfer between the components (the nicotine and the one or more ers) in a co-crystal. In contrast, a nicotine salt co-crystal is a type of hybrid structure with both salt and stal features. Typically, a nicotine molecule within a salt stal is associated with at least two coformers (which may be the same or different), in which one er is in ionic form such as an acid and transfers a proton to the nicotine molecule and the second coformer does not transfer a proton to the ne molecule.

Any form of ne, including nicotine salts, nicotine co-crystals, and/or nicotine salt co-crystals may be utilized herein for any onsert, precision rod or precision pod embodiment.

As used herein, "cigarette" means any roll of tobacco, which may e non- tobacco materials, wrapped in paper that when lit ts and produces smoke. A cigarette usually also includes a filter, plug wrap (constrains the filtration als) and tipping paper (holds the cigarette paper to the filter and plug wrap). Glue seals the cigarette paper together, and if the cigarette has a filter, glue holds these other components together. The term cigarette shall also include any roll of tobacco wrapped in any substance containing tobacco which, because of its appearance, the type of tobacco used, or its packaging and labeling, is likely to be offered to, or purchased by, consumers as a cigarette. An example is a e cigar’ which may include a filter and generally looks very similar to a tte. Factory-made cigarettes mean cigarettes that are fabricated and rolled in a factory by a o manufacturer, and unless provided to smokers as research cigarettes, factory-made cigarettes are lly sed at retail stores by end users.

Factory-made cigarettes usually come in packs of twenty cigarettes. As used herein, "marijuana cigarette" means any roll of is wrapped in paper or any other non-tobacco material that when lit combusts and produces smoke for inhalation. A marijuana tte (i.e., joint) does not contain tobacco; r, may yield nicotine or other tobacco alkaloids if an onsert or precision rod, as disclosed herein, is attached to or is inserted within the marijuana cigarette. A marijuana cigarette may be rolled by cannabis end users or fabricated in a factory by a cannabis manufacturer. Unlike a marijuana cigarette, a blunt is marijuana rolled in a tobacco leaf or cigar wrapper that comprises tobacco, and a spliff is a marijuana cigarette which also contains tobacco.

As opposed to factory-made cigarettes, roll-your-own (RYO) cigarettes or makeyour-own (MYO) cigarettes are put together by tobacco end users. RYO cigarettes are made with tobacco and rolling papers. A cigarette roller may also be utilized to roll the tobacco into the rolling paper. MYO cigarettes are generally made with tobacco and a mechanical MYO machine in which the tobacco is inserted into an empty cigarette tube (with or without a filter). A mechanism inserts the tobacco into the tube and the result is a cigarette that looks very similar to typical store-bought factory-rolled cigarettes. Although RYO (tobacco and rolling papers) or MYO (tobacco and tubes) cigarettes are lly each cheaper for ers to se than factory-made ttes, RYO and MYO cigarettes are time consuming and tedious to assemble and y do not have the uniformity or quality of factory-made cigarettes. RYO o and MYO tobacco are essentially the same and closely resemble filler of factory-made cigarettes.

RYO tobacco, MYO tobacco and pipe tobacco are all finished tobacco products (as defined below) which tobacco end users purchase to smoke.

As used herein, "filler" means the cumulative smokable material (besides cigarette paper), wrapped in the rod of a cigarette, or in a tobacco stick of a tobacco heating device (or in tobacco heating rod [e.g., TEEPS®] if no separate holder in a tobacco heating product), selected from the group consisting of cut o leaf (cut-rag), tobacco stem, reconstituted tobacco, expanded o, cannabis, casings, flavorings and other additives or ingredients such as cannabinoids or additional alkaloids such as anatabine. Reconstituted tobacco is usually included in the filler of factory-made cigarettes and resembles cut-rag tobacco. Expanded tobacco is also usually included in the filler of factory-made cigarettes and is processed through the expansion of suitable gases so that the tobacco is d’ resulting in reduced density and greater g ty of the tobacco rod. Expanded tobacco reduces the weight of tobacco used in cigarettes.

As used herein, "reconstituted tobacco," also known as Recon, means tobacco sheet produced by the g or casting of tobacco dust, stems and/or ducts that have previously been finely ground are then mixed with a ve agent or binder and typically humectants, flavors and preservatives are included. The result in a paper-like ble sheet which is essentially ed tobacco. The two types of reconstituted tobacco known in the art are band cast and paper cast. F or each of these, every producer has a slightly different process. The Recon process allows virtually any compound or plant fraction to be added. Once the reconstituted tobacco sheet is fabricated, it is then cut into small strips. The size and shape of the strips are typically similar to the size of g tobacco, and the reconstituted tobacco may be blended into the filler of cigarettes; however, the large sheets of Recon can be cut to any size. See, e.g., U.S. s 4,270,552 and 5,724,998 and Chapter 11, 377-379, Tobacco: Production, Chemistry and Technology, 1999. Nicotine, anatabine, anabasine, THCA, CBDA, CBCA, CBGA, THCVA, CBDVA, CBCVA, CBGVA, myrcene, caryophyllene, pinene, limonene and/or ne may be further incorporated during the Recon production process before the sheets are fabricated. In some exemplary embodiments , the reconstituted tobacco sheet is utilized for production of wrappers for onserts and the Recon sheets are cut accordingly, or the reconstituted tobacco sheet may be very finely cut, ground and incorporated into precision pods or precision rods. In other exemplary embodiments, very low nicotine tobacco is reconstituted and utilized for onserts, precision rods or precision pods.

As used , "reconstituted cannabis" means a cannabis sheet produced in the same fashion as reconstituted tobacco sheet in which cannabis s, leaves, dust, stems and/or by-products that have been previously finely ground are then rolled or casted and mixed with a cohesive agent or binder which usually includes ants, flavors and preservatives.

Reconstituted cannabis sheet does not require any tobacco portions so it can be made tobacco free, and if no nicotine is desired, it can be made nicotine free, and is easily made into reconstituted sheets similar to reconstituted tobacco. The cannabis n of the reconstituted cannabis sheet may be made from approximately 70 percent to approximately 90 percent is plant parts.

Once fabricated, reconstituted cannabis sheet is cut to any size desired. In some exemplary embodiments, the reconstituted cannabis is utilized for production of wrappers for onserts or cut very fine and incorporated into precision pods or ion rods. Nicotine, anatabine, anabasine, THCA, CBDA, CBCA, CBGA, THCVA, CBDVA, CBCVA, CBGVA, myrcene, caryophyllene, pinene, limonene and/or humulene may be r incorporated during the Recon production process before the reconstituted cannabis sheets are ated. Very low THC cannabis or THC- free cannabis may be produced from hemp strains or varieties, or strains or varieties of is that are genetically engineered for very low THC t and utilized for reconstituted cannabis.

Very low THC cannabis and low nicotine (or zero nicotine) tobacco may both be utilized in the same reconstituted sheet.

In other exemplary embodiments, reconstituted plant material (e.g., leaves and stems) is utilized for production of wrappers for onserts or for use in precision pods or precision rods, and the reconstituted sheet does not include any o or cannabis. Herbs such as jasmine and g, for example, are utilized for production of "reconstituted herbal sheet." r reconstituted tobacco, reconstituted cannabis and/or reconstituted jasmine, for e, nicotine, anatabine, anabasine, THCA, CBDA, CBCA, CBGA, THCVA, CBDVA, CBCVA, CBGVA, myrcene, caryophyllene, pinene, limonene and/or humulene are incorporated (infused) during the Recon production process before the reconstituted sheets are fabricated.

As used herein, hed tobacco product" means a tobacco product that is ready for consumer use or consumption and includes but is not limited to cigarettes, cigars, little cigars, cigarillos, roll-your-own (RYO) o (used with rolling papers by end users to roll their own ttes or marijuana cigarettes), make-your-own (MYO) o (used with cigarette tubes and a mechanical MYO machine, typically by end users to make their own cigarettes or marijuana cigarettes, in which the tobacco or cannabis is inserted by the machine into an empty cigarette tube), cannabis, pipe tobacco, tobacco heating products (e.g., IQOS®), snuff, snus, and chewing tobacco such as dipping tobacco. E-cigarettes are not tobacco products since the only fraction of tobacco they contain is nicotine. RYO tobacco or MYO tobacco may not be designated as either on packaging and may be referred to as "tobacco" since it can be used as RYO tobacco or MYO tobacco.

As used herein, "smoking t" means any product that is ready for consumer use or consumption that when used by itself (e.g., cigarette) or used with an interdependent g product (e.g., a pipe and pipe tobacco are interdependent on one another) produces mainstream smoke for inhalation (except smoke from n cigars may not be inhaled by some cigar smokers, due to the high nicotine content and high pH of the smoke resulting in nicotine being absorbed through the mouth) when ignited, and includes but is not limited to cigarettes, cigars, roll-your-own (RYO) tobacco, cannabis, rolling papers for RYO tobacco or cannabis, make-your-own (MYO) tobacco, cigarette tubes for MYO tobacco or cannabis, pipes, bowls, bongs, o, reconstituted tobacco, spliffs, blunts, and marijuana cigarettes. RYO tobacco and MYO tobacco, dually or collectively, may be referred to herein as ‘tobacco’ or ‘finished tobacco.’ A bowl is a type of pipe that typically has a shorter stem. The ‘tobacco chamber,’ ‘cannabis chamber’ or ‘chamber’ is where tobacco or cannabis is burned in pipes, bowls and bongs. Onserts, precision rods and n precision pods (those not for vaporizers) are also smoking ts.

As used , "conventional cigarette" means a cigarette having a conventional nicotine content of at least 9 mg per cigarette. The average nicotine content of conventional commercial cigarette brands is approximately 14 mg of ne per tte but may range from approximately 9 mg to over 20 mg of ne per cigarette. See Morton et al. 2008, Regul Toxicol Pharmacol. doi: 10.1016/j.yrtph.2008.03.001.

As used herein, "very low nicotine cigarette" means a cigarette containing 2.0 milligrams (mg) nicotine per cigarette or less such as less than 0.05 mg, 0.10 mg, 0.15 mg, 0.20 mg, 0.25 mg, 0.30 mg, 0.35 mg, 0.40 mg, 0.45 mg, 0.50 mg, 0.55 mg, 0.60 mg, 0.65 mg, 0.70 mg, 0.75 mg, 0.80 mg, 0.85 mg, 0.90 mg, 0.95 mg, 1.00 mg, 1.05 mg, 1.10 mg, 1.15 mg, 1.20 mg, 1.25 mg, 1.30 mg, 1.35 mg, 1.40 mg, 1.45 mg, 1.50 mg, 1.55 mg, 1.60 mg, 1.65 mg, 1.70 mg, 1.75 mg, 1.80 mg 1.85 mg, 1.90 mg or 1.95 mg nicotine per tte. Per cigarette nicotine content is calculated by multiplying the weight of the filler in a cigarette rod by the nicotine content of the filler in the cigarette rod. For example, if the filler of a cigarette weighs 0.666 gram and has a nicotine content of 3 mg/g, the nicotine content of the cigarette is about 2 mg. Filler having a nicotine content of 3 mg/g equates to an approximate 85% reduction of the average ne t of tobacco filler in conventional cigarette brands which is approximately 20 mg/g.

Very low nicotine cigarettes have been manufactured by the tobacco industry at various times for decades. For e, John Alden Tobacco Company manufactured the John Alden very low nicotine cigarette brand in the 1950s and advertised the brand as "At least 85% less nicotine than the two leading filter tip brands." The low-nicotine tobacco used in John Alden very low nicotine cigarettes was classified by the U.S. Department of Agriculture as Type 31-V.

In addition to growing tobacco that y has very low ne, other processes have been developed. For example, Philip Morris USA developed a commercial supercritical CO2 process to remove 97% of nicotine from filler and sold various brands of very low nicotine ttes.

As used herein, a "nicotine-enhanced cigarette" means a cigarette which includes an adjunct source of nicotine (e.g., from an onsert or precision pod) resulting in the nicotine smoke yield of the cigarette being increased by equal to or greater than 7 percent, as measured by an industry-accepted, standardized, smoking-machine test method (e.g., International Standards Organization [ISO] smoking-machine test method 4387:2000 [Cigarettes - Determination of total and ne free dry particulate matter using a routine analytical smoking machine]), as compared to the nicotine smoke yield of the cigarette without the adjunct source of ne as measured by the same said test method. The nicotine yield of very low nicotine cigarettes or conventional cigarettes may be enhanced by an adjunct source of nicotine. Other examples of industryaccepted , standardized, smoking-machine test methods are the Canadian intense method, the Massachusetts , and the Federal Trade Commission (FTC) method. Besides an t source of nicotine, ne-enhanced cigarettes, may also utilize a device used in conjunction with the adjunct source of nicotine such as a cigarette holder.

Depending on the design of the cigarettes being infused with an adjunct nicotine source, ing the level of ventilation of the cigarette, the increase in nicotine smoke yield will vary from cigarette type to cigarette type for a given amount of adjunct nicotine (e.g., a precision rod comprising of 10 mg ne). Just as a small tage of the nicotine in the filler of a cigarette (the average nicotine content of a cigarette is about 14 mg) transfers to mainstream smoke (may be measured by a smoking machine), which ranges from approximately one t of the nicotine content for highly ventilated cigarettes to imately ten percent of the nicotine content for virtually non-ventilated cigarettes, a similarly small percentage of nicotine is transferred from an onsert or precision rod to mainstream smoke. This nicotine transfer rate, which is the rate that the nicotine t in the filler of a cigarette (and/or the nicotine content of the nicotine onsert) transfers to the mainstream smoke as measured by a smoking machine, also depends on if any (or the level of) burn accelerators or ash conditioners are included in the tte paper and/or source of adjunct nicotine (e.g., onsert). The way smoking products including cigarettes are smoked (i.e., intensely, by taking large and frequent puffs, or not) also affects the nicotine transfer rate of cigarettes with or without t nicotine sources. Specific smoking s such as the ISO, Canadian intense method, or Massachusetts method each standardizes nicotine yields with or t onserts or precision rods.

The increased nicotine yield of the smoke of a nicotine-enhanced cigarette may be equal to, for example, at least 0.002 mg, 0.003 mg, 0.004 mg, 0.005 mg, 0.006 mg, 0.007 mg, 0.008 mg, 0.009 mg, 0.010 mg, 0.011 mg, 0.012 mg, 0.013 mg, 0.014 mg, 0.015 mg, 0.016 mg, 0.017 mg, 0.018 mg, 0.019 mg, 0.020 mg, 0.025 mg, 0.030 mg, 0.035 mg, 0.040 mg, 0.045 mg, 0.050 mg, 0.055 mg, 0.060 mg, 0.065 mg, 0.070 mg, 0.075 mg, 0.080 mg, 0.085 mg, 0.090 mg, 0.095 mg, 0.100 mg, 0.125 mg, 0.150 mg, 0.175 mg, 0.200 mg, 0.225 mg, 0.250 mg, 0.275 mg, 0.300 mg, 0.325 mg, 0.350 mg, 0.375 mg, 0.400 mg, 0.425 mg, 0.450 mg, 0.475 mg, 0.500 mg, 0.525 mg, 0.550 mg, 0.575 mg, 0.600 mg, 0.625 mg, 0.650 mg, 0.675 mg, 0.700 mg, 0.725 mg, 0.750 mg, 0.775 mg, 0.800 mg, 0.825 mg, 0.850 mg, 0.875 mg, 0.900 mg, 0.925 mg, 0.950 mg, 0.975 mg or 1.000 mg nicotine, et cetera. For example, a nicotine-enhanced cigarette may be a very low nicotine cigarette in which the ne yield increased from 0.03 mg to 0.05 mg.

As used herein, an "anatabine-enhanced cigarette" means a cigarette which includes an adjunct source of anatabine resulting in the cigarette having an increased anatabine yield of equal to or greater than 7 percent, as measured by a testing method e of quantitating anatabine in smoke, and as compared to the same type of factory-made tte without said adjunct source of anatabine and measured by the same test method. For an example of such a testing method, see Zhang et al. 2018, Rapid Commun Mass Spectrom., 32:1791–1798 (DOI: .1002/rcm.8222). The anatabine yield of very low nicotine cigarettes or tional cigarettes may be enhanced by an adjunct source of anatabine such as from an onsert or precision rod.

This anatabine source may be plants including tobacco plants with high anatabine in which the anatabine is extracted by, for e, a supercritical CO2 extraction process. The anatabine content may also be enhanced by anatabine salts of c acids, anatabine analogs or synthesized anatabine. The sed anatabine yield of the smoke of an anatabine-enhanced cigarette may be equal to, for example, at least: 0.10 μg, 0.15 μg, 0.20 μg, 0.25 μg, 0.30 μg, 0.35 μg, 0.40 μg, 0.45 μg, 0.50 μg, 0.55 μg, 0.60 μg, 0.65 μg, 0.70 μg, 0.75 μg, 0.80 μg, 0.85 μg, 0.90 μg, 0.95 μg, 1.00 μg, 1.10 μg, 1.20 μg, 1.30 μg, 1.40 μg, 1.50 μg, 1.60 μg, 1.70 μg, 1.80 μg, 1.90 μg, 2.0 μg, 2.25 μg, 2.50 μg, 2.75 μg, 3.0 μg, 3.25 μg, 3.50 μg, 3.75 μg, 4.0 μg, 4.25 μg, 4.50 μg, 4.75 μg, 5.0 μg, 5.25 μg, 5.50 μg, 5.75 μg, 6.0 μg, 6.25 μg, 6.50 μg, 6.75 μg, 7.0 μg, 7.25 μg, 7.50 μg, 7.75 μg, 8.0 μg, 8.25 μg, 8.50 μg, 8.75 μg, 9.0 μg, 9.25 μg, 9.50 μg, 9.75 μg, 10 μg, 11 μg, 12 μg, 13 μg, 14 μg, 15 μg, 16 μg, 17 μg, 18 μg, 19 μg, 20 μg, 21 μg, 22 μg, 23 μg, 24 μg, 25 μg, 30 μg, 35 μg, 40 μg, 45 μg or 50 μg of anatabine per cigarette. An advantage of an anatabine- enhanced very low nicotine cigarette is that this type of tte reduces withdrawal and craving of conventional cigarettes more effectively than very low nicotine cigarettes t enhanced anatabine. Anatabine-enhanced very low nicotine cigarettes are especially useful when used to assist smokers in transitioning to e-cigarettes or a tobacco heating device or to assist smokers in quitting tobacco and nicotine use altogether.

As used , an "anabasine-enhanced cigarette" means a cigarette which includes an adjunct source of anabasine resulting in the cigarette having an increased ine smoke yield of equal to or greater than 7 percent, as measured by a testing method capable of quantitating ine in smoke, and as compared to the same type of factory-made cigarette without said adjunct source of anabasine and measured by the same test method. For an example of such a testing , see Zhang et al. 2018, Rapid Commun Mass Spectrom., 32:1791–1798 (DOI: 10.1002/rcm.8222). The anabasine yield of very low nicotine cigarettes or conventional cigarettes may be enhanced by an adjunct source of anabasine such as from an onsert or precision This anabasine source may be plants ing tobacco plants or plants in which the predominant alkaloid is anabasine such as Nicotiana glauca, Nicotiana lora, Nicotiana oides and/or Nicotiana debneyi plants. The anabasine may be extracted by, for example, a supercritical CO2 extraction process from any type of tobacco. The ine content may also be enhanced by anabasine salts of organic acids, anabasine analogs or synthesized anabasine. The increased anabasine yield of an anabasine-enhanced cigarette may be equal to, for example, at least: 0.01 μg, 0.02 μg, 0.03 μg, 0.04 μg, 0.05 μg, 0.06 μg, 0.07 μg, 0.08 μg, 0.09 μg, 0.10 μg, 0.15 μg, 0.20 μg, 0.25 μg, 0.30 μg, 0.35 μg, 0.40 μg, 0.45 μg, 0.50 μg, 0.55 μg, 0.60 μg, 0.65 μg, 0.70 μg, 0.75 μg, 0.80 μg, 0.85 μg, 0.90 μg, 0.95 μg, 1.00 μg, 1.10 μg, 1.20 μg, 1.30 μg, 1.40 μg, 1.50 μg, 1.60 μg, 1.70 μg, 1.80 μg, 1.90 μg, 2.0 μg, 2.25 μg, 2.50 μg, 2.75 μg, 3.0 μg, 3.25 μg, 3.50 μg, 3.75 μg, 4.0 μg, 4.25 μg, 4.50 μg, 4.75 μg, 5.0 μg, 5.25 μg, 5.50 μg, 5.75 μg, 6.0 μg, 6.25 μg, 6.50 μg, 6.75 μg, 7.0 μg, 7.25 μg, 7.50 μg, 7.75 μg, 8.0 μg, 8.25 μg, 8.50 μg, 8.75 μg, 9.0 μg, 9.25 μg, 9.50 μg, 9.75 μg, 10 μg, 11 μg, 12 μg, 13 μg, 14 μg, 15 μg, 16 μg, 17 μg, 18 μg, 19 μg, 20 μg, 21 μg, 22 μg, 23 μg, 24 μg, 25 μg, 26 μg, 27 μg, 28 μg, 29 μg or 30 μg of anabasine per cigarette. An advantage of an ine-enhanced very low nicotine cigarette is that this type of cigarette reduces withdrawal and craving of conventional cigarettes more ively than very low nicotine cigarettes without enhanced anabasine. Anabasine-enhanced very low nicotine cigarettes are especially useful when used to assist smokers in transitioning to e-cigarettes or a tobacco heating device or to assist smokers in quitting tobacco and nicotine use altogether.

Total alkaloid levels or individual alkaloid levels such as the level of nicotine, anatabine or anabasine in tobacco or filler can be measured by several methods known in the art.

Examples include quantification based on gas chromatography (GC) and high-performance liquid chromatography. See, e.g., Lisko et al. 2013, Anal Chem. March 19; 85(6): 3380-3384, which provides the following methods used to e ties of alkaloids in the filler of cigarette brands and in o types (e.g., burley tobacco). The analysis of minor alkaloids such as anatabine or anabasine has been med with gas chromatography (GC) coupled with a wide spectrum of detection techniques including flame ionization detection (FID), nitrogen-phosphorus detection (NPD), and mass spectrometry (MS). Other analysis approaches have included highperformance liquid chromatography-ultraviolet detection (HPLC-UV), capillary zone electrophoresis-ultraviolet detection (CZE-UV), micellar electrokinetic capillary chromatographyultraviolet ion UV), nitrogen chemiluminescence detection (NCD), and microemulsion electrokinetic chromatography-ultraviolet detection (MEEKC-UV). ation of gas chromatography-tandem mass spectrometry (GC-MS/MS) in multiple reaction mode (MRM) allows for greater compound specificity by eliminating matrix ions g from other compounds that share the same parent mass but lack the correct transition ion, drastically decreasing background interferences and reducing detection limits. The amount of nicotine (and propylene glycol and glycerol) in e-liquids or blends in precision rods or precision pods may be determined by ISO/DIS 20714, which is a gas chromatographic method, or any other method known in the art.

Unless specified or insinuated otherwise, analyte measurements (e.g., nicotine) are on a dry weight basis.

For any exemplary ment , nicotine is first provided by any of the various methods known in the art for extracting nicotine, anatabine and anabasine from Nicotiana plants such as high nicotine N. rustica plants and then purifying the extract. These methods are ed for nicotine replacement therapy products like the ne lozenge and nicotine patch.

Alternatively, in other embodiments, synthetic nicotine, synthetic anatabine or synthetic anabasine is first provided, which offers advantages of not being extracted from tobacco. See, for example, U.S. Patent No. 9,556,142 and Ayers et al. 2005 The AAPS Journal; 7(3) Article 75, E752-E758 //www.aapsj.org). The nicotine is then prepared preferably in a solid or semi-solid form by any of the methods known in the art. These may be in crystalline and/or amorphous form.

Upon crystallization or solidification, the nicotine salt may be cut or ground to form any shape or size ing on the application. For ne powder applications, the size may be as small as 25 microns, and for other application the size may be 5 mm. Alternatively, nicotine salts are available commercially. For example, ne bitartrate dehydrate, a pure, soluble crystalline salt of nicotine in a powder form and used for the production of nicotine lozenges and gums is available from Alchem International SA.

ELECTRONIC NICOTINE DELIVERY SYSTEMS (ENDS) Many types of ENDS have been developed and marketed over the past decade. For example, a tobacco heating product is comprised of a holder, o sticks and a charger. The IQOS® tobacco stick (HeatStick®), for example, is inserted into the IQOS® holder which heats the o material by means of an onically-controlled heating blade. The HeatStick® differs from a cigarette in many ways. For example, the tobacco in the HeatSticks® for the IQOS® product does not burn and is made from tobacco powder uniquely processed and specifically designed to function with the holder to produce an aerosol. In another exemplary uration, a o g device is ignited like a conventional cigarette. There may not be any holder, charger or battery and the o may be directly heated in a tobacco heating rod.

For example, an ignited carbon heat source heats (and does not burn) the tobacco and produces an aerosol similar to o heating devices which comprise of separate tobacco sticks. The types of tobacco heating devices with carbon heat sources, for example, closely resemble a typical cigarette physically, but do not burn. The disposable heating element is contained in each rod producing the aerosol that is inhaled, known herein as a "tobacco heating rod" or "heating rod." An example is TEEPS® which is being developed by Philip Morris International. Other examples include Eclipse® and Revo®, which were previously sold in the United States but are no longer on the market. In another uration, a tobacco heating device has no holder or charger and includes a battery in every heating rod and each heating rod may be disposable. Accordingly, it is tood that any device that heats tobacco (or tobacco extract or a form of tobacco such as reconstituted tobacco) below combustion (does not burn the tobacco) to produce an aerosol is a tobacco heating device less whether there are separate tobacco sticks from the holder or heating element, whether ng a battery is required or a y is even required, whether something needs to be ignited such as the end of a carbon heat source, and/or whether any electronics are involved. The terms, o heating device, tobacco heating product, heat-not-burn tobacco device, and heatnot-burn tobacco product as used herein are synonymous.

An e-cigarette is a rechargeable electronic device which includes a heating coil, atomizer that transforms the e-liquid (also known as e-juice) to an aerosol, cartridge or the like (sticks or pods) containing the e-liquid, iece and battery for recharging the device.

Although there are many appearances and designs that may encompass varying steps, they generally operate by drawing on the e-cigarette, activating a heating element which aerosolizes the e-liquid, allowing the aerosol to be inhaled. E-liquids typically contain nicotine, water, flavors and humectants. The humectant acts as a carrier solvent which dissolves the nicotine and flavors and aerosolizes at a certain temperature on the atomizer of the e-cigarette. Typically, propylene glycol and/or glycerol are the solvents used in e-liquids. The e-liquid of rettes which is contained in cartridges, for example, have nicotine contents which vary widely by brand and brand style.

A zer (vape) vaporizes substances, typically plant material such as cannabis, for inhalation without burning the substances. These include both dry herb vaporizers (e.g., for cannabis flowers) and vaporizers configured for plant extracts such as concentrates or waxy extracts. Some vaporizers are configured for both dry herbs and concentrated extracts such as the PAX 3®. zers configured for dry herbs and/or concentrates are typically open systems allowing the user to place whatever is desired to be heated into the oven chamber and then the oven r is closed with a cover or the like. These types of open system vaporizers such as the PAX 2® are differentiated from closed system vaporizers such as glo® and IQOS® which use tobacco sticks and the tobacco is not ible; however, open system vaporizers work rly to glo® and IQOS® since open systems like the also generate vapor from smokable plant material (e.g., is), which typically have moisture levels from about 10 percent to about 17 percent.

The to-vape precision pods disclosed herein are capable of working with dry herb zers and zers for concentrates which is advantageous. Open system vaporizers are also differentiated from e-cigarettes in that e-cigarettes utilize ids and open system vaporizers do not. As compared to the exemplary embodiments herein of the ready-to-vape precision pods comprising concentrated forms of nicotine, e-cigarettes cause the user to inhale a much greater volume of vapor for a satisfying dose of nicotine (e.g., 1 mg) since the nicotine in eliquids is cally diluted to concentrations generally not greater than 0.7 ml nicotine by volume, which equals 5% nicotine by weight. Some other vape devices offer e-liquids at higher concentrations, but none are close to the tration of nicotine in blends of ready-to-vape ion pods, for example, comprising a crystalline cannabinoid and crystalline salt of nicotine.

A vaporizer includes an electronic heater with temperature regulator, oven or vaporization chamber (where the materials to be heated are placed), cover for oven chamber, mouthpiece, sensors and a geable battery. Generally, as compared to burning is from g products, significantly more extraction of cannabinoids occurs with vaporizers heating cannabis due to lack of combustion. Typical temperatures of vaporizers in the oven chamber range from about 160° C. to about 230° C. resulting in a vapor for inhalation; however, ranges can be wider (e.g., 100° C. to 265° C.) since higher temperatures are needed for concentrates.

Mainstream vapor is vapor that is inhaled and includes the vapor that emerges from the mouth of a person using a vaporizer or that emerges from the mouth end of a vaporizer.

CANNABIS AND CANNABIS ATIONS "Cannabis" as used herein includes Cannabis sativa, Cannabis indica and is ruderalis. Both marijuana and hemp strains or cultivars are cannabis. Hemp is genetically more similar to the indica type of marijuana than to sativa s. Cannabinoids are the group of more than 100 natural chemical compounds that mainly accumulate in female flowers (also known as buds) of cannabis . They act on cannabinoid receptors in cells that alter neurotransmitter release in the brain. THCA/THC is one of the dozens of cannabinoids present in cannabis plants. inoids may be ed intrinsically by a genetically engineered tobacco plant, produced synthetically (see, for e, U.S. Patent 9,587,212) or extracted from cannabis plants for use s, precision rods and precision pods. When smokers cease smoking conventional cigarettes their levels of anxiety and depression usually increase; ore, very low nicotine cigarettes in conjunction with an onsert or precision rod comprising a minimal amount of crystalline CBDA is beneficial in assisting smokers to switch to e-cigarettes or a tobacco heating device or to quit tobacco and nicotine use altogether. For these ations, smoke from very low nicotine cigarettes also containing non-THC cannabinoids from an onsert or ion rod is an improvement over smoke from very low nicotine cigarettes t cannabinoids. The greater period of time during a transitional period smokers are able to exclusively smoke very low nicotine cigarettes (while not smoking any conventional cigarettes), as disclosed in U.S. Patent Application No. ,948, the greater probability of them switching to e-cigarettes or a tobacco heating product or quitting tobacco and nicotine use altogether.

The psychoactive effects of THC are primarily mediated by the activation of cannabinoid receptors located throughout the body and are part of the endocannabinoid system, which is involved in a y of physiological processes such as mood and appetite. Utilizing hemp strains (containing significant THCA content) or marijuana strains or varieties is problematic to include in very low nicotine cigarettes to assist smokers in switching to e-cigarettes or a tobacco heating device since the psychoactive effects of THC would interfere with the daily lives of smokers in that their physical and mental control would be diminished. For example, a smoker attempting to switch to e-cigarettes or a tobacco heating device would not be able to smoke very low ne cigarettes ning significant levels of THCA during a lunch break while at work without becoming intoxicated and therefore may not be able to function normally upon ing to work and may become a danger to coworkers. Moreover, employees may fail drug tests if their very low nicotine cigarettes include is which contains THCA. Therefore, it is useful and ageous to include crystalline CBDA (and not cannabis) from an onsert or precision rod in conjunction with very low ne ttes or conventional cigarettes, or from a precision pod in conjunction with a vaporizer to prevent any of the psychoactive effects of THC while retaining the benefits CBD. Crystalline CBDA which is 99.5 percent pure does not have any of the intoxicating effects of THC whatsoever.

The cannabinoid biosynthetic pathway in Cannabis sativa is understood.

Cannabigerolic acid (CBGA) is the precursor to the three main inoid lines: tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA), and cannabichromenic acid . During oxylation, which occurs during drying and curing of the plant material and/or upon the ation of heat (e.g., smoking) to the cannabinoid acid, each of the following 8 cannabinoid acids: CBGA (cannabigerolic acid), THCA (Δ9-tetrahydrocannabinolic acid), CBDA (cannabidiolic acid), CBCA (cannabichromenenic acid), CBGVA (cannabigerovarinic acid), THCVA (tetrahydrocanabivarinic acid), CBDVA (cannabidivarinic acid) and CBCVA (cannabichromevarinic acid), converts to and yields the following corresponding 8 cannabinoid compounds: CBG (cannabigerol), THC (Δ9–tetrahydrocannabinol), CBD (cannabidiol), CBC (cannabichromene), CBGV (cannabigerivarin), THCV (tetrahydrocannabivarin), CBDV (cannabidivarin) and CBCV (cannabichromevarin). As cannabis cures and moisture is reduced, the cannabinoid nds in their acidic form mature and are slowly converted into related compounds (e.g., THCA to THC). Curing cannabis and storing it over time only causes partial decarboxylation to occur, which is the reason cannabis flowers generally test positive, for example, for both THCA and THC (designated herein as THCA/THC). Smoking or vaporizing cannabis will oxylate cannabinoids in acidic form (e.g., THCA to THC) due to the high temperatures present, making them instantly available for absorption through inhalation.

The cannabinoid acid content of the exemplary embodiments herein of onserts, precision rods or precision pods such as CBDA includes the corresponding cannabinoid since partial decarboxylation may have occurred to the cannabinoid acid such as CBDA to CBD. For example, during ical g of cannabinoid acids and cannabinoids of onserts, ion rods, precision pods, cannabis plants, cannabis s and cannabis ies, an item that is quantified as containing 24 mg CBDA and 1 mg CBD is equivalent to the item described herein as mg CBDA. ore, it is understood herein that due to the potential partial decarboxylation of cannabinoid acids to cannabinoids, a cannabinoid acid and cannabinoid may at times be used interchangeably and expressed as, in this instance, 25 mg CBDA, 25 mg CBD or 25 mg CBDA/CBD, all of which have the equivalent meaning.

Every strain or variety of cannabis has a unique cannabinoid profile, which is the content of each cannabinoid in a batch or blend of cannabis divided by the total content of all cannabinoids, measured in percent, or the ratio of one or more cannabinoids to one or more other cannabinoids. An example of a cannabinoid profile in a 10-pound batch of a cannabis is that the THCA/THC content is 65 percent of the total content of all cannabinoids and the remaining cannabinoids comprise the remaining 35 t. The non-THCA/THC cannabinoids may be further terized. The ratio of THCA to CBDA is also an example of a inoid profile.

Multiple samples are taken from a batch or plant and blended for testing purposes and more than one replicate may be done. Regardless of cannabis strains or variety, CBDA/CBD and THCA/THC are typically the two most prevalent cannabinoids in is. There’s usually an e relationship between THCA and CBDA across cannabis strains and varieties. T he higher the THCA/THC content, the lower the CBDA/CBD content, and the higher the CBDA/CBD content, the lower the THCA/THC content. CBDA/CBD is generally the most abundant cannabinoid combination in hemp strains or varieties. THCA/THC is generally the most abundant cannabinoid combination in marijuana strains, which typically can be imately between 10 and 20 percent of the weight of the cannabis flower. This CBDA-CBD/THCA-THC relationship of hemp and ana is due to the fact that for centuries hemp has been bred for seed and biomass and ore contains more CBDA/CBD, while marijuana has been bred for pleasurable effects and therefore contains more THCA/THC. While THCA is the more accurate label for cannabis flower that has not been decarboxylated, THCA or THC are often used interchangeably and are essentially equivalent if the flower is going to be smoked, vaporized or heated in some way since heat converts the remaining THCA to THC.

As described herein, e dose formulations of blends of one or more crystalline salts of nicotine and one or more crystalline cannabinoids used with devices disclosed herein (onserts, precision rods and precision pods) t many types of harm reduction products particularly for those smokers who simultaneously use tobacco and marijuana. o enhances the pleasurable effects of marijuana when both are smoked simultaneously or when tobacco is smoked shortly after marijuana is smoked. This synergistic effect is due in part to the stimulatory properties of nicotine such as sed heart rate. Some smokers combine o and marijuana in blunts or spliffs. A blunt is marijuana rolled in a tobacco leaf or cigar r that comprises tobacco, and a spliff is a joint which also contains o. Blunts and spliffs are combusted and therefore produce ‘tar’ and harmful gases which contain thousands of chemicals. Inhaling smoke from burning highly pure forms of crystalline CBDA or THCA, for example, in ction with burning a crystalline salt of nicotine, and without any cannabis and tobacco plant material, is less harmful than inhaling smoke from blunts or spliffs since the blend of these pure or nearly-pure crystals results in a significant reduction of mainstream smoke for a given level of cannabinoid and nicotine. Moreover, vaping highly pure, blended forms of crystalline THCA and a crystalline nicotine salt in precision pods, for example, without any propylene glycol and glycerin or with very small amounts (as compared to e-cigarettes), is less harmful than smoking a blunt or spliff.

Propylene glycol and vegetable glycerin, which are in e-liquids at high percentages, are considered safe and acceptable substances as food additives; however, there is insufficient data for inhaling these compounds long-term. During the summer of 2019, reports began surfacing about irritated and inflamed lungs from vaping e-liquids that included oils containing THC and vitamin E acetate.

Separately, a study showed that ng nicotine-free e-cigarette aerosol transiently impacted elial function in y nonsmokers. See Caporale et al. 2019, doi: .1148/radiol.2019190562. These highlight the usefulness of the devices disclosed herein which deliver formulations of active ingredients (e.g., nicotine and inoids) that are concentrated while eliminating or minimizing the level of carriers such as propylene glycol and glycerin.

Whether smoked or vaped, for a given dose of nicotine or THCA, for example, highly pure forms of THCA and/or salts of nicotine result is less smoke being inhaled, as compared to blunts or spliffs, and less vapor being d, as compared to vaping cannabis flowers (buds).

Any extraction method known in the art may produce a cannabinoid acid in crystalline form or near lline form. These extracted cannabinoid acids, as measured by highperformance liquid chromatography, are preferably at least 90 percent pure, more preferably at least 95 percent pure, more preferably at least 98 percent pure, more preferably at least 99 percent pure, and most preferably at least 99.5 percent pure. These extraction methods include those with liquid carbon dioxide (CO2) under supercritical or itical conditions, followed by at least one other r extraction, such as an ethanolic precipitation method to remove a ntial proportion of any remaining non-cannabinoid materials such as plant waxes, wax esters and glycerides, terpenes, carotenes, flavonoids and unsaturated fatty acid residues. See, for example, U.S. Patents 7,700,368 and 8,846,409.

The ation of one or more cannabinoid acids and/or one or more salts of nicotine may be included in any exemplary embodiment herein of onserts, ion rods, or precision pods. Any cannabinoid acid, including those in crystalline or near crystalline form, may be utilized including one or more cannabinoid acids selected from the following: CBGA (Cannabigerolic acid), THCA (Δ9-tetrahydrocannabinolic acid), CBDA (cannabidiolic acid), CBCA (cannabichromenenic acid), CBGVA (cannabigerovarinic acid), THCVA (tetrahydrocanabivarinic acid), CBDVA (cannabidivarinic acid) and CBCVA bichromevarinic acid). Any salt of nicotine (nicotine salt), whether in crystalline form, near crystalline form, polymorphic crystalline form, and/or amorphous form, may be utilized including one or more selected from the following: nicotine 4-acetamidobenzoate, nicotine ascorbate, nicotine aspartate, nicotine benzoic, nicotine rate, nicotine chloride such as nicotine dihydrochloride and nicotine hydrochloride, nicotine citrate, nicotine 2,3-dihydroxybenzoate, nicotine 3,5-dihydroxybenzoate, nicotine fumarate, nicotine gentisate (2,5-hydroxybenzoic), ne glutamate, nicotine l-hydroxynaphthoate, nicotine 3-hydroxybenzoate, nicotine lactate, nicotine nic, nicotine malate, nicotine mono-pyruvate, nicotine mucate, nicotine perchlorate, nicotine pyruvate, nicotine salicylate, nicotine succinate, nicotine sulfate, ne tartrate and nicotine zinc chloride.

FLAVORINGS AND ADDITIVES The onserts, precision rods and ion pods disclosed herein, in addition to alkaloids and cannabinoids, may also contain any ing and/or additives. Smokers being able to ize their very low nicotine cigarettes with additives or characterizing flavorings during the treatment period of methods to facilitate switching smokers to e-cigarettes or a tobacco heating t, as disclosed in U.S. Patent Application No. 16/047,948, is crucial for smokers to better tolerate these non-conventional cigarettes. For example, l menthol crystals from peppermint oil or oils of other mints may be included in any embodiment herein. Crystalline menthol is clear or white in color and becomes a vapor when tobacco smoke goes through the crystals in precision rods or when precision pods are heated in zers causing the menthol essence to permeate mainstream vapor. Menthol crystals, as a solid, blend well with crystalline cannabinoid acids and crystalline salts of nicotine formulations. Any type of flavoring, whether or not in crystalline form, may be included in onserts, precision rods or precision pods and other examples of characterizing s include vanilla (e.g., vanillin), cherry, grape, mango, orange, clove, blueberry, peach, cinnamon, coconut, ce, chocolate, fruit, coffee, strawberry, pineapple, cucumber, lemon, lime, mint and toffee. Commercial cigarettes characterized and labeled ‘menthol’ contain anywhere from about 2 mg to 20 mg of l. Any onsert, precision rod or precision pod may comprise an amount of the foregoing terizing flavors of at least 1 mg, 2 mg, 3 mg, 4 mg, 5 mg, 6 mg, 7 mg, 8 mg, 9 mg, 10 mg, 11 mg, 12 mg, 13 mg, 14 mg, 15 mg, 16 mg, 17 mg, 18 mg, 19 mg, 20 mg, 21 mg, 22 mg, 23 mg, 24 mg, 25 mg, 26 mg, 27 mg, 28 mg, 29 mg, 30 mg, 31 mg, 32 mg, 33 mg, 34 mg, 35 mg, 36 mg, 37 mg, 38 mg, 39 mg, 40 mg, 41 mg, 42 mg, 43 mg, 44 mg, 45 mg, 50 mg, et cetera.

Additives are also ant to enhance some of the ations of the onsert, precision rod and precision pod embodiments . For example, formulations of crystalline cannabinoids and salts of nicotine are devoid of flavors and aromas since all of the plant terpenes have been extracted or were never t in the case of compounds being synthesized. es are the pungent oils which give cannabis its distinctive aroma and taste. Every strain has a distinct terpene e. These cannabis terpenes may be reintroduced into formulations of onserts, precision rods and precision pods to add character such as taste and aroma to the smoke or vapor.

Although more than 100 terpenes have been identified, the most prevalent terpenes in cannabis include myrcene, caryophyllene, pinene, limonene and humulene.

Additives may also be utilized in the exemplary embodiments of s, precision rods, or ion pods to ameliorate any harshness of a lline nicotine salt, other crystalline alkaloids, crystalline cannabinoids, and/or other lline compounds. The pH of the smoke or vapor produced from the formulations of onserts, ion rods and ion pods is analyzed and adjusted accordingly by the addition of ingredients to shift the pH of the smoke or vapor. For e, if the pH of smoke generated from the formulation of a precision pod under development is greater than about 5.5, sugars, mild acids such as citric acid or fatty acids may be added to blends in precision pods, precision rods or onserts. Plant materials or other tuents may also be added to formulations herein which include plant parts, plant fractions, or plants constituents from herbs (e.g., jasmine or ginseng), cannabis, tobacco and/other plants.

Other functional additives such as preservatives or non-tobacco alkaloids such as cytisine, also known as cytisinicline, are useful. Cytisine is a plant-based alkaloid present in many plant genera, such as Cytisus and Laburnum (e.g., Cytisus laborinum or golden rain acacia).

Cytisinicline has a high binding affinity to the nic acetylcholine receptor. It has been used as a smoking cessation treatment in pill form in some European countries. In some exemplary embodiments, including at least 2 mg of cytisinicline in an onsert, precision rod or precision pod reduces the urge to smoke conventional cigarettes and assists smokers transitioning to e-cigarettes or a tobacco heating product or to quit tobacco and ne use altogether.

In some aspects of the present invention, products and ations are provided for smokers to enhance the nicotine, anatabine and/or anabasine smoke yield (i.e., levels) of smoking products such as y-made very low nicotine cigarettes to tate smokers, who are not interested in quitting tobacco and nicotine products altogether, to switch from smoking conventional cigarettes to using e-cigarettes or a tobacco heating device. In this methodology, very low nicotine cigarettes may be utilized as a bridge between the smoker’s usual cigarette brand and e-cigarettes or between the smoker’s usual cigarette brand a tobacco heating product.

In other aspects, products and formulations are provided for smokers to enhance the nicotine smoke yield of their factory-made conventional cigarettes to reduce a ’s re to cigarette smoke including ‘tar’ and carbon monoxide.

In other aspects, products are provided for s to add new characterizing flavor(s) or to enhance flavor(s) in the smoke of smoking products such as ttes.

In other aspects, products are provided for smokers to add nicotine, anatabine and/or anabasine to marijuana cigarettes.

In other aspects, products are provided for smokers to include cannabinoids or other additives or constituents to their smoking products.

In other aspects, products and formulations are provided to allow smokers to enjoy the effects of cannabinoids and nicotine without being exposed to cotine tobacco compounds.

EXAMPLE 1 ONSERTS FOR SMOKING PRODUCTS To enhance the ne smoke yield, nicotine is ed with onserts for the er to apply the onserts onto, around, or within smoking products such as cigarettes. The nicotine adhered or infused to the onsert is preferably in the form of a salt of nicotine. The onsert, which comprises of a wrapper made from or including cellulose (e.g., reconstituted cannabis), may be approximately as long as the smoking product such as a cigar and may be any shape or size including wide enough to wrap around a cigarette. As shown in the exemplary embodiment of FIGS. 1A-1C, an onsert 1 comprising a cellulosic wrapper 2 is configured for wrapping around the entire circumference of the tte rod 3 of a factory-made cigarette. The width of the cellulosic wrapper 2 of the onsert 1 is larger than the circumference of the cigarette so that both sides 4, 5 of the onsert overlap the cigarette rod to sufficiently seal the cigarette. The self -adhesive (self-stick) side 6 of the onsert 1, which has self-stick adhesive around the entire perimeter (all four sides) 7 of the onsert, is rolled around the cigarette rod 3 while pressing the onsert to the cigarette rod 3. As shown in and , the nicotine salt 8 or any other form of nicotine (along with any other compounds or constituents the onsert may comprise) is adhered to the cellulosic wrapper 2 of the onsert, and in this exemplary embodiment, there is no nicotine on the te side 9 of the onsert 1. Alternatively, in some exemplary embodiments, the nicotine and any other compounds or constituents are infused within the osic wrapper during the production process by methods known in the art such as those for reconstituting plant materials (e.g., reconstituted tobacco sheet or tituted cannabis sheet). In other exemplary embodiments, the nicotine is , that is, encased between a closed pocket of opposing sheets (i.e., an encasement or closed pouch) by methods known in the art for producing sugar packets or silica gel s.

The entire cigarette rod 3 is now wrapped within the onsert 1, as shown in .

The onsert 1 and the cigarette are adhered to one another and the seal is improved by the smoker pressing along the length of the nicotine-enhanced tte at the seam 10. The self-stick onserts may be packaged for distribution in any form such as on non-stick sheets (backing paper), each sheet comprising at least one onsert which is peeled off the non-stick sheet, or the self-stick onserts may be on a continuous roll of multiple onserts in series which are be peeled off the roll one at a time from ick g paper. Although self-stick onserts are preferred, ves may be utilized that are activated when moistened (e.g., licked) in order to stick. Any moisture activated ve that is known in the art may be utilized on onserts.

Once the cigarette is lit and smoked, a portion of the nicotine from the onsert is transferred to, and becomes part of, the mainstream smoke. The onsert may comprise of any cellulosic al in the form of a wrapper or strip which is burnable and smokable such as any paper or cellulosic material, cigarette paper, reconstituted tobacco sheet including forms used to roll machine made cigars, reconstituted cannabis sheet, formulations of hemp such as hemp paper, and/or cellulosic materials made from other plants such as herbal plants (e.g., ginseng or jasmine).

An advantage of the configuration of the onsert in FIGS. 1A-1C is that other ingredients may be easily added to the onsert (between the onsert and cigarette) before the onsert is completely rolled around the cigarette.

In some exemplary embodiments, the onsert is fabricated by covering the onsert with a nicotine salt in conjunction with a binder, stabilizer and/or adhesive known in the art. In this ology, for example, about 3 parts gum arabic (from the acacia tree and also known as arabic gum or acacia gum) are mixed with about 1 part glycerin and about 1/6 part water in a ner for 15 minutes resulting in an adhesive to hold the nicotine salt to the onsert. A thin coat of the binder, stabilizer or adhesive may be applied to uncut sheets after formation (e.g., hemp paper) on the same and/or opposite side of the self-adhesive side for sticking the onsert onto the cigarette. If the nicotine salt is applied to the self-adhesive side, none is applied to where the ve is present such as around the perimeter 7 of the onsert, as shown in . The ne salt covering in powder or flake form is then applied at the desired rate to one or both sides of the sheets shortly following the ation of the binder, stabilizer or adhesive causing the nicotine salt coating to stick to the sheets. After drying, subsequent coats of the , stabilizer or adhesive and nicotine salt may be applied to the sheets. The binder, stabilizer or adhesive may be d as the final coat thereby better trapping the ne on the sheets. The uncut sheets are then cut into multiple onserts at the desired shape and sizes. Onserts configured to wrap around the entire circumference of the smoking product may be any size such as those sizes to completely wrap around, for example, cigars or 100 mm cigarettes. Therefore, the size and type of the g product in part dictates the size and configuration of the onsert. The amount of nicotine salt (and/or other compounds) applied to the onsert is also based on the type and teristics of the smoking product (e.g., ventilation level) and on the level of increase of nicotine yield desired (or the level of increase in yield of any other compounds desired). The increase in nicotine yield (or yield of other compounds) is therefore a function of the type and characteristics of the smoking product and the type and size of the onserts being utilized, including the level compounds included in or on the .

In other exemplary embodiments, a nicotine salt along with other compounds may be infused n two onsert sheets or among more than two onsert sheets, with or without the onsert sheets being covered with nicotine salts on the outside portions of each sheet. In this fabrication arrangement, the gum arabic formulation above (or any other binder, stabilizer or adhesive formulation being utilized) may be used to seal the edges of the two or more sheets or the onserts after the sheets are subsequently cut into le onserts for packaging. Self-stick onserts are preferably utilized in this embodiment for the consumer to peel and stick the nicotine onsert onto a cigarette or other smoking product. By not covering and adhering the onsert sheets with nicotine, the nicotine in this fabrication arrangement essentially remains in an ment between the sheets for a neater consumer application.

The nicotine onserts disclosed herein (and the precision rods and precision pods disclosed and described below) may also include other alkaloids, flavors, cannabinoids, terpenes and/or other ves or constituents. For example, any of the exemplary embodiments herein may be carried out with ine or anabasine instead of ne or in ation with ne, including the exemplary onsert embodiments of FIGS. 1A-1F, whether in nicotine salt formats, nicotine co-crystal formats, or nicotine salt co-crystal formats. Both anatabine and anabasine are alkaloids similar to nicotine and instead of producing salts of nicotine, salts of anatabine or salts of anabasine may be produced for ine-enhanced ttes and anabasine-enhanced cigarettes.

Salts of nicotine may be blended with salts of anatabine and/or salts of ine, and salts of anatabine may be blended with salts of anabasine for cigarettes or for marijuana cigarettes with any level or combination of enhanced nicotine, enhanced anatabine or ed anabasine.

Synthetic versions of these alkaloids may also be utilized.

Each onsert, regardless of which type, may comprise one or more compounds selected from the group consisting of nicotine, anatabine, anabasine, flavor, Δ9- tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA), cannabichromenenic acid (CBCA), cannabigerolic acid (CBGA), ydrocanabivarinic acid (THCVA), cannabidivarinic acid (CBDVA), cannabichromevarinic acid (CBCVA), cannabigerovarinic acid (CBGVA), myrcene, caryophyllene, , limonene and humulene. Each onsert may comprise at least the ing amounts of each of the aforementioned compounds: 0.10 mg, 0.20 mg, 0.30 mg, 0.40 mg, 0.50 mg, 0.60 mg, 0.70 mg, 0.80 mg, 0.90 mg, 1.0 mg, 1.1 mg, 1.2 mg, 1.3 mg, 1.4 mg, 1.5 mg, 1.6 mg, 1.7 mg, 1.8 mg, 1.9 mg, 2 mg, 3 mg, 4 mg, 5 mg, 6 mg, 7 mg, 8 mg, 9 mg, 10 mg, 11 mg, 12 mg, 13 mg, 14 mg, 15 mg, 16 mg, 17 mg, 18 mg, 19 mg, 20 mg, 21 mg, 22 mg, 23 mg, 24 mg, 25 mg, 26 mg, 27 mg, 28 mg, 29 mg, 30 mg, 31 mg, 32 mg, 33 mg, 34 mg, 35 mg, 36 mg, 37 mg, 38 mg, 39 mg, 40 mg, 41 mg, 42 mg, 43 mg, 44 mg, 45 mg, 46 mg, 47 mg, 48 mg, 49 mg, 50 mg, 51 mg, 52 mg, 53 mg, 54 mg, 55 mg, 56 mg, 57 mg, 58 mg, 59 mg, 60 mg, 61 mg, 62 mg, 63 mg, 64 mg, 65 mg, 66 mg, 67 mg, 68 mg, 69 mg, 70 mg, 71 mg, 72 mg, 73 mg, 74 mg, 75 mg, 76 mg, 77 mg, 78 mg, 79 mg, 80 mg, 81 mg, 82 mg, 83 mg, 84 mg, 85 mg, 86 mg, 87 mg, 88 mg, 89 mg, 90 mg, 91 mg, 92 mg, 93 mg, 94 mg, 95 mg, 96 mg, 97 mg, 98 mg, 99 mg, 100 mg, 110 mg, 120 mg, 130 mg, 140 mg, 150 mg, 160 mg, 170 mg, 180 mg, 190 mg, 200 mg, 250 mg, et cetera.

For example, an onsert may contain at least 30 mg of nicotine and not any other component listed above or may contain, for example, at least 10 mg nicotine, at least 10 mg THCA and at least 10 mg CBCA. An onsert may contain more than one alkaloid, nd or additive. I n some exemplary embodiments, onserts such as the type of onsert shown in may be utilized specifically to ly roll cannabis and/or tobacco including MYO or RYO finished tobacco blends into the onsert. In other exemplary embodiments, onserts may comprise any of the aforementioned amounts (i.e., at least 0.10 mg h at least 250 mg) of conventional tobacco, low nicotine tobacco, conventional cannabis (i.e., marijuana) and/or very low THC cannabis, with or without any of the aforementioned one or more nds.

In some ary embodiments, the self-stick or moisture-activated adhesive is on the same side of the cellulosic wrapper as the one or more compounds, and in other embodiments, the adhesive is on the opposite side of the cellulosic wrapper as the one or more compounds. In still other embodiments, the one or more compounds are within an encasement and the encasement may be in the middle of the cellulosic wrapper. An onsert may comprise of any compound or combination of nds, whether the compounds are in an encasement within a cellulosic wrapper or adhered to a cellulosic wrapper, including any of the above amounts (i.e., at least 0.10 mg through at least 250 mg) of nicotine, anatabine or anabasine not extracted from a Nicotiana plant; that is synthesized nicotine, anatabine or anabasine, and the onsert may comprise any of the above amounts (i.e., at least 0.10 mg through at least 250 mg) of one or more of the following cannabinoid acids: THCA, CBDA, CBCA, CBGA, CBGVA, THCVA, CBDVA and CBCVA that are synthesized, that is, produced outside a Cannabis plant.

Any strain, variety or blend of cannabis may be enhanced by s comprising one or more cannabinoids for rolling a marijuana , variety or blend of cannabis flowers or other plant parts into the onsert such as the type of onsert shown in . This is sometimes ed since the cannabinoid e of the dozens of cannabinoids, including the THCA/CBDA ratio and content, of flowers of the same ana strain can vary significantly from one harvest to another, ally when grown in different growing conditions. These onserts may be ne free and tobacco free and are an ideal way to modify the cannabinoid profile of the smoke from any strain, variety or blend of cannabis flowers without requiring an additional strain, variety or blend of cannabis flowers. For example, an onser t may comprise THCA, CBDA, CBGA, and/or any other cannabinoid for cannabis users to either fortify their marijuana cigarettes, blunts, or s or to change the cannabinoid profile of the smoke from any strain, variety or blend of cannabis in order to achieve desired effects.

In on to the advantage of any compounds being present on the onsert so that they are included as a new compound not present in the smoking product or provided as an t to a compound already present in the smoking product, the design of the onsert shown in for directly rolling cannabis and/or tobacco into the onsert has other important advantages over typical RYO ttes or RYO marijuana cigarettes. For example, the onsert is more convenient and less messy especially when implemented as a self-stick onsert, the onsert provides a seal on all four sides y ng smoke dilution from unwanted air flow caused by loose rolls. Also, less tobacco or cannabis can be used, especially if the nicotine and/or cannabinoids included with the onserts are pure or ure (e.g., ≥ 90 pure). In fact, as compared to a cigarette (with or without added cannabinoids), which averages about 650 mg of tobacco (plus the weight of any cannabinoids), an onsert for a smoking product comprising, for example, 20 mg THCA, 10 mg of a nicotine salt, and 200 mg of plant material (whether it is tobacco, cannabis or a blend of the two) rolled into the onsert translates into a smoking product with about 69 percent less plant material.

This in turn means that there will be a significant reduction in smoke tion including ‘tar’ inhalation from the onsert, as compared to an average cigarette (with or without added cannabinoids). There will also be a significant reduction in carcinogenic TSNAs since less o is used in conjunction with the onsert.

In some exemplary ments, synthetic nicotine may be the only active ingredient included with an onsert (or with a precision rod) so that cannabis users can enjoy the effects of nicotine (not extracted from tobacco) with their is. r synthetic nicotine or nicotine extracted from a Nicotiana plant is utilized, onserts (or a precision rod comprising nicotine) that provide nicotine to the mainstream smoke from marijuana cigarettes (e.g., cannabis rolled with an onsert such as the onsert in FIGS. 1A-1C) effectively eliminates the need to include any tobacco and the result is a less harmful smoking product, as compared to a spliff, since less plant material needs to be ted because tobacco is not needed for its nicotine t, thereby reducing smoke inhalation and eliminating tobacco carcinogens such as TSNAs.

It will be appreciated that onserts herein may be any shape or form and any selfstick adhesive (or other ves such as those that e moisture to activate) on the onsert may be continuous or in any pattern. For example, the self-stick adhesive is on all four sides 7 surrounding the nicotine salt 8 of the onsert 1 in . In modified exemplary embodiments, one, two or three sides of the onsert may comprise the self-stick adhesive (or other adhesives such as those that require moisture to activate), or one or more additional strips of adhesive may be added such as through either axis of symmetry of the onsert. Any percentage of either side of an onsert may be comprised of an adhesive. Onserts, ing the onserts of FIGS. 1A-1F, may also contain filters, which would be attached to one end of the onsert. Burn accelerators or ash conditioners may be included in or on the onserts. It will also be appreciated that onserts may actually be used as more of an ‘insert’ in that they may be stuck to the inside of roll-your-own (RYO) rolling papers or placed inside of empty make-your-own (MYO) tte tubes (or mixed into the loose tobacco or cannabis for RYO or MYO) before the smoking product is rolled or made by a smoker (i.e., the onsert is hidden after the RYO g product is rolled or the after the MYO smoking product is made). When used in this fashion, the transfer rate of one or more ids, flavors, cannabinoids, terpenes, and/or other additives into the mainstream smoke of the smoking product is lly higher, as compared to placing an identical onsert on the e of the smoking product (e.g., placed on a filled MYO cigarette). Of course, for onserts made specifically to be placed on the inside of RYO or MYO smoking products, the self-stick adhesive feature is optional as is any other adhesive that is activated when moistened (e.g., licked) in order to stick to the smoking product. These exemplary embodiments of s which may be inserted into a smoking product may not comprise of any adhesives to stick to smoking products.

FIGS. 1D-1F show exemplary configurations of self-adhesive (self-stick) onserts comprising of cellulosic wrappers which differ in shape from the onsert in FIGS. 1A-1C. As shown in , the first type of onsert includes a circular window 11 with either two wings 12 or four wings 13 and comprises one or more alkaloids, flavors, cannabinoids, terpenes, and/or other additives. Each of these onserts are positioned around the circular tip of a smoking product such as a cigarette, cigar or marijuana cigarette and the wings, which may be any length, are extended and stuck to the smoking product. Another type are elongated onserts 14 shown in , which may be positioned, for example, both in parallel along the side of a smoking product such as a cigar or one or both onserts may be wrapped around the smoking t. The ids, flavors, cannabinoids, terpenes, and/or other additives of the onserts in the exemplary embodiments of FIGS. 1D-1E, may be encased between a closed pocket of opposing sheets of the onsert, adhered to either side of the onserts by an adhesive, or infused within the onsert during the production process of the onsert.

Another type of onsert configuration is a web pattern onsert shown in exemplary embodiment of , which is r to the onsert of FIGS. 1A-1C as it pertains to function since the onsert may be wrapped around a smoking product such as a tte, be used in conjunction with tobacco and/or is to roll (RYO) a cigarette, marijuana cigarette, blunt or spliff, or simply may be rolled and smoked by itself without any interdependent smoking t.

On the self-stick adhesive side of the onsert 15, there may be one, two, three or four sides of adhesive around the webbing 16, which comprises the alkaloids, flavors, cannabinoids, terpenes and/or other additives encased in the webbing that is in front of a back sheet 17. These types of non-continuous (i.e., webbed) onserts may be any shape or size and may cover any n of a smoking product.

In some exemplary embodiments, the onserts may be included inside of a pack of factory-made cigarettes or may be bundled together (e.g., 20) and adhered to the outside of a cigarette pack or rolling paper box as a package onsert. An advantage of ing the nicotine onserts within or on factory-made cigarette packs is the convenience such packaging ts when an adjunct amount of nicotine may be required by some smokers when using very low nicotine cigarettes to exclusively switch from smoking conventional cigarettes to rettes or a tobacco heating , as outlined in U.S. Patent Application No. 16/047,948. These nicotine enhanced ttes (e.g., nicotine s plus very low nicotine cigarettes) assist the smoker to exclusively use the very low nicotine cigarettes during the treatment period, as directed by the protocol, so that the smoker does not cheat and smoke conventional cigarettes during the treatment period. The adjunct amount of nicotine provided by the nicotine onsert(s) may se the ne smoke yield, for example, from 0.04 mg to 0.10 mg per cigarette. Although the nicotine smoke yield more than doubled in this e, the 0.10 mg nicotine yield is still dramatically lower than the typical 1 mg nicotine yield of conventional cigarettes. Nicotine onserts providing an adjunct amount of nicotine to factory-make conventional cigarettes afford great flexibility to s customizing their cigarettes in the interest of smoking less of each cigarette. A nicotineenhanced cigarette in which an onsert comprising nicotine has been attached to a conventional cigarette results in a reduction of the tar-to-nicotine ratio.

EXAMPLE 2 PRECISION RODS FOR SMOKING PRODCUTS Precision rods comprising an exact amount of one or more flavors, alkaloids, cannabinoids, terpenes and/or other additives, or constituents are fabricated to be inserted into a g product to remain in the smoking product during the combustion of the smoking product with the purpose of transferring one or more flavors, alkaloids, cannabinoids, terpenes and/or other additives, or constituents into the mainstream smoke generated by the smoking product. Precision rods provide precisely quantified ations of compounds of interest as either an adjunct to the intrinsic content of one or more compounds already ed in smoking product or as one or more new compounds. There are three types of precision rods. The first type of precision rod is comprised of als that combust and burn down as the smoking product burns down such as a cigar. Suitable cellulosic materials of these types of ion rods are those which have an ignition temperature of equal to or less than 350 degrees Celsius. Ignition temperature is the least temperature at which a nce starts combustion. These materials must also be sufficiently rigid (or by design can be made to be sufficiently rigid) to be ed into, for example, the tobacco end of a ed cigarette and can be burned with the smoking product without presenting unacceptable levels of toxins into the mainstream smoke of the smoking t. Examples of suitable materials for osic precision rods include but are not limited to fiberboard, paper, paperboard or other cellulosic or woody materials, which are preferably produced from hemp or reconstituted hemp, tobacco or reconstituted tobacco, or other plants in which the flavor, alkaloid, cannabinoid, terpene, and/or other additives, or constituents of interest, are adhered to or housed (contained) within a chamber or hollow space in the precision rod. In some exemplary embodiments of precision rods (and precision pods), the compounds and constituents are ed in reconstituted hemp, reconstituted o, or other plant material that has been reconstituted, which is then included in the space or inner chamber of precision rods (or in the compartment of precision pods).

As shown in the exemplary embodiment of , a cellulosic precision rod 18 is comprised of six layers of multi-ply paperboard 19 in which each layer of the multi-ply paperboard is covered, for example, by a nicotine salt r any other compounds), and then all the layers are bound together by a binder or adhesive that is designated, G enerally Recognized As Safe (GRAS), by the U.S. Food and Drug Administration (FDA). A cellulosic precision rod may comprise of one or more layers of a cellulosic material. One or more layers of the cellulosic precision rod are bound together during the production process of the layer(s) so that no additional binder or ve is necessary. The entire assembled precision rod may be covered with a thin GRAS coating or film so that the nds are sealed onto the precision rod and they don’t get on the user’s hands. In other exemplary embodiments, one or two thick layers may be utilized for a cellulosic precision rod, and these types of cellulosic precision rods that utilize thick layers may also comprise at least one chamber or hollow space to house greater amounts of a nicotine salt and/or other compounds.

The second type of precision rod in other exemplary embodiments is comprised of materials that do not combust or burn down as the g product burns down and have an ignition temperature of more than 350 degrees Celsius. These pr ecision rods comprise of one or more flavors, alkaloids, cannabinoids, terpenes, and/or other ves, or constituents of interest, and are fabricated to be inserted into either end of the g t to remain in the smoking product during the tion of the smoking product with the purpose of transferring these compounds or constituents to the mainstream smoke generated by the smoking product. Examples of suitable flame-resistant, rigid als include but are not limited to fused quartz or silica, ceramics such as earthenware or porcelain, or non-toxic ultra -high-temperature ceramics. For embodiments in which only a few puffs will be taken so that the precision rod cannot escape the smoking product and burn the , non-toxic metal or metal alloys such as titanium or foodgrade stainless steel may be employed.

As shown in , there are three exemplary embodiments of cylindrical precision rods of various sizes that do not combust or burn down as the smoking product burns down, including the first precision rod 20. These three precision rods comprise of an inner chamber to house compounds and/or plant materials. The inner chamber 21 begins at the opening at the end of the first precision rod 20, has a diameter of about 1.25 mm and a length of about 13 mm. The first precision rod 20 comprises about 15 mg of a salt of nicotine in powder form ty of about 900 kg/m3) within the inner chamber 21. One end of each precision rod may be pointed for easy insertion into any smoking product such as a y-made cigarette. A precision rod comprises of one or more holes or vents which also lead to the inner chamber 21. There are various holes 22 across each ion rod in (only a portion of them are labeled). The number of holes or vents s on the type of smoking product, the type of compounds or constituents included in the precision rod and their boiling points, the amount of each compound in the precision rod, and the total weight of contents in the precision rod. The holes or vents and the end opening of a precision rod, all of which lead to the inner chamber, tate the flow of air, heat and smoke entering and exiting the precision rod. The end g and holes or vents of a precision rod may be sealed with arabic gum or any GRAS material which easily melts upon being heated. T he holes or vents may be kept unsealed, in which case the le sizes of the compounds are made larger than the holes or vents, and during production the compounds are inserted through the end opening. The end opening may be covered with a peel off tab which the consumer removes before inserting the precision rod into the smoking product. The entire precision rod may be sealed with c for the consumer to peel off before use.

As shown in , the precision rod 20 of has been inserted into a cigarette 23. Upon the nicotine-enhanced cigarette being smoked, which now includes the precision rod, the holes allow air, heat and smoke to enter the precision rod as nicotine (and/or other compounds in other ary embodiments) contained within the rod vaporizes and permeate into the mainstream smoke. Once the nicotine-enhanced tte 23 (or other smoking product in other embodiments) is partially smoked down, the cigarette may be d out or the precision rod may be released with the ashes of the cigarette. The smoker will likely be satisfied with only a portion of the nicotine-enhanced cigarette being smoked (e.g., 40%) due to the t nicotine in the precision rod of 15 mg. The smoker may dispose of the partially smoked cigarette or may save the unsmoked portion for later when another precision rod can be inserted into the remaining portion of the cigarette. In either case, the smoker inhales approximately half of the smoke, which includes ‘tar,’ as compared to g the same cigarette without the precision rod.

The amount of ne inhaled is about the same as if the same cigarette without the precision rod was smoked since the average cigarette contains about 15 mg of nicotine; the same amount in the precision rod. In addition to reducing harm, the smoker also has the option of benefitting economically by purchasing fewer cigarettes if the other half of each cigarette is saved.

The first two types of precision rods may also be inserted into the mouth end of a g product which may be the filter of a smoking product such as a filtered cigarette or filtered cigar. For example, a precision rod comprising 8 mg of menthol crystals may be inserted into the mouth end (e.g., filter end) of a tte. The holes or vents of precision rods allow the essence of the l crystals to enter the mainstream smoke and deliver menthol sensations and satisfaction to the smoker. Since smoking very low nicotine cigarettes do not result in any significant throat impact, as compared to smoking conventional cigarettes, menthol or other flavoring(s) in precision rods increase the acceptability of very low nicotine cigarettes, which tate smokers quitting tobacco products altogether and facilitate smokers switching to ecigarettes or a tobacco heating device (as sed in U.S. Patent Application No. 16/047,948).

E-cigarettes and tobacco g devices are both generally ed to be much less l than smoking cigarettes. Vaping e-cigarettes, for example, is believed to be approximately 90 percent less harmful than smoking cigarettes.

The third type of precision rod is used in conjunction with a flavor ion system. This type of precision rod also comprises one or more flavors, alkaloids, cannabinoids, terpenes and/or other additives, or constituents, and is inserted into a smoking product such as one or more cigarettes or cigars. The compounds in the inner chamber are injected into the g product and the precision rod is then d from the smoking t. As shown in , the flavor injection system comprises a ion rod 24 and a plunger mechanism 25. The plunger mechanism 25 includes a plunger which is not shown in . The precision rod 24 includes a fastening mechanism at one end, which in this exemplary embodiment is thread 26 so that the precision rod can be screwed into the thread 27 of the plunger mechanism 25. The precision rod includes an end hole 28, which is the beginning of the inner chamber that houses the compounds or constituents before they are injected into a smoking product. Once the precision rod 24 is inserted into a smoking product and the precision rod and the plunger mechanism 25 are then connected (or the order may be reversed), the plunger, which is connected to the plunger mechanism, is pushed into the plunger mechanism 25 and the contents in the precision rod are emptied into the smoking product. Upon the smoking product being ignited, the mainstream smoke of the smoking t will be infused with the one or more compounds (and any constituents) now included in the smoking product.

In some exemplary embodiments, the flavor injection system and the precision rod are one piece and do not have to be connected. The flavors, ids, cannabinoids, terpenes and/or other additives or constituents may be loaded ly into the r mechanism or precision rod by a y of ways. For example, the r may be removed from the plunger mechanism, and the compounds and constituents are emptied or placed into the plunger mechanism which pass through to the precision rod. The plunger is then reattached. The flavor injection system is now ready to infuse a smoking product with the contents in the flavor injection system. Any of the foregoing exemplary embodiments of flavor injection systems may be automated with any type of machine in which one or more smoking products, i.e., one or more cigarettes, for example, are infused with compounds at once or in succession.

Each precision rod, regardless of which of the three types, may comprise one or more compounds selected from the group consisting of nicotine, anatabine, anabasine, flavor, Δ9- tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA), cannabichromenenic acid (CBCA), cannabigerolic acid (CBGA), tetrahydrocanabivarinic acid (THCVA), cannabidivarinic acid (CBDVA), cannabichromevarinic acid (CBCVA), cannabigerovarinic acid (CBGVA), myrcene, caryophyllene, , limonene and ne. Each of the three types of precision rods may comprise at least the following amounts of one or more of the aforementioned compounds: 0.10 mg, 0.20 mg, 0.30 mg, 0.40 mg, 0.50 mg, 0.60 mg, 0.70 mg, 0.80 mg, 0.90 mg, 1.0 mg, 1.1 mg, 1.2 mg, 1.3 mg, 1.4 mg, 1.5 mg, 1.6 mg, 1.7 mg, 1.8 mg, 1.9 mg, 2 mg, 3 mg, 4 mg, 5 mg, 6 mg, 7 mg, 8 mg, 9 mg, 10 mg, 11 mg, 12 mg, 13 mg, 14 mg, 15 mg, 16 mg, 17 mg, 18 mg, 19 mg, 20 mg, 21 mg, 22 mg, 23 mg, 24 mg, 25 mg, 26 mg, 27 mg, 28 mg, 29 mg, 30 mg, 31 mg, 32 mg, 33 mg, 34 mg, 35 mg, 36 mg, 37 mg, 38 mg, 39 mg, 40 mg, 41 mg, 42 mg, 43 mg, 44 mg, 45 mg, 46 mg, 47 mg, 48 mg, 49 mg, 50 mg, 51 mg, 52 mg, 53 mg, 54 mg, 55 mg, 56 mg, 57 mg, 58 mg, 59 mg, 60 mg, 61 mg, 62 mg, 63 mg, 64 mg, 65 mg, 66 mg, 67 mg, 68 mg, 69 mg, 70 mg, 71 mg, 72 mg, 73 mg, 74 mg, 75 mg, 76 mg, 77 mg, 78 mg, 79 mg, 80 mg, 81 mg, 82 mg, 83 mg, 84 mg, 85 mg, 86 mg, 87 mg, 88 mg, 89 mg, 90 mg, 91 mg, 92 mg, 93 mg, 94 mg, 95 mg, 96 mg, 97 mg, 98 mg, 99 mg, 100 mg, 110 mg, 120 mg, 130 mg, 140 mg, 150 mg, 160 mg, 170 mg, 180 mg, 190 mg, 200 mg, et cetera. For example, a precision rod may contain at least 30 mg of anatabine and not any other component listed above or may contain at least 10 mg nicotine, at least 10 mg THCA and at least 10 mg CBGVA. A precision rod may contain more than one id, compound or additive. In some exemplary embodiments, each of the three types of precision rods may further se any of the aforementioned amounts, i.e., at least 0.10 mg through at least 200 mg, of conventional o, low nicotine tobacco, conventional cannabis (i.e., marijuana) and/or very low THC cannabis, with or without any of the aforementioned one or more compounds.

In other exemplary embodiments, a precision rod may comprise any of the aforementioned s (i.e., at least 0.10 mg through at least 200 mg) of nicotine, anatabine or anabasine not extracted from a Nicotiana plant; that is synthesized nicotine, anatabine or anabasine, and they may comprise any of the aforementioned amounts (i.e., at least 0.10 mg through at least 200 mg) of one or more of the following cannabinoid acids: THCA, CBDA, CBCA, CBGA, CBGVA, THCVA, CBDVA and CBCVA that are synthesized, that is, produced outside a Cannabis plant. For example, a precision rod may contain 30 mg of THCA and not any other component listed above or may contain 10 mg nicotine, 10 mg THCA and 10 mg CBCA. A ion rod may also contain more than one alkaloid, flavor or other ve.

Precision rods may be any shape or length and depend in part on the amount of flavor, alkaloid, cannabinoid and/or other additive desired to be transferred to the mainstream smoke. Elongated shapes with a pointed end are generally preferred for easier insertion into smoking products such as cigars. Precision rods may be fabricated ing, for example, CBDA crystalline (e.g., 20 mg), which is ‘pure’ CBD and les sugar. The crystalline CBDA or any other crystalline cannabinoid may be provided by any method known in the art such as supercritical CO2 extraction ses followed by various pass throughs of purification by ethanolic precipitation, for example, in order to remove remaining impurities until the CBDA is approximately 99 percent pure. The preparation is then ground to a size no smaller than about 100 s or so and may be blended with other compounds or constituents and it’s then orated into the precision rod. These precision rods may be utilized by smokers using very low nicotine cigarettes to tion to e-cigarettes or a tobacco heating product, or for quitting tobacco and nicotine products ther; the methods and products of which are disclosed in U.S. Patent Application No. 16/047,948. Precision rods may contain any combination of flavors, ids, cannabinoids and/or other additives, or constituents. For example, and for recreational purposes, a precision rod may contain 10 mg nicotine, 10 mg of CBDA crystalline, 20 mg of THCA crystalline, and 10 mg of menthol crystals.

Any onsert, insert, or precision rod disclosed herein may be applied to any type of cigarette, including make-your-own (MYO) cigarettes in which the t nicotine source may be positioned on the inside of the empty tte tube before filling the tube with tobacco, and rollyour-own (RYO) cigarettes in which the adjunct nicotine source may be positioned on the inside of a flat rolling paper before the tobacco is rolled. Otherwise, the onsert, insert, or precision rod may be used with MYO and RYO cigarettes (that are y filled with tobacco) similarly to how they are used with factory-made cigarettes. Any onsert, insert, or precision rod disclosed herein may be applied to any other type of smoking product such as cigars or marijuana smoking products (e.g., joints), whether these g products are factory made or hand made by ers. For example, after removing some tobacco from the tobacco end of a factory-made cigarette, an onsert or precision rod may be placed within that tobacco end, and a n of the removed tobacco may be put back into the cigarette before lighting the cigarette.

EXAMPLE 3 PRECISION PODS FOR VAPORIZERS AND SMOKING PRODUCTS Tobacco and cannabis users lack the capability, including product s and formulations, to conveniently vape or smoke a precisely quantified amount of solid or semi solid form of nicotine and inoids such as one or more crystalline cannabinoid acids in conjunction with one or more crystalline alkaloids (with or without terpenes, flavors and other additives, or plant constituents). Ready-to-vape or ready-to-smoke precision pods are configured for use with vaporizers, pipes, bongs, bowls and the like for the purpose of conveniently vaping or smoking an exact pre-measured and blended amount of one or more compounds, which the precision pods comprise, such as cannabinoids and alkaloids with both the cannabinoid and alkaloid in a solid or semi-solid form. In some exemplary embodiments, precise formulations of d lline cannabinoid ) and crystalline salt(s) of nicotine are ed in precision pods. Precision pods are advantageous on many front s, ally for those who simultaneously smoke or vape tobacco and cannabis or for those who may not necessarily smoke or vape tobacco and cannabis aneously, but are dual users of tobacco and cannabis.

From a harm ion standpoint, vaping crystalline cannabinoid acid(s) and a crystalline salt of nicotine in ready-to-vape precision pods is less harmful than vaping marijuana buds and tobacco together or vaping an rette and marijuana buds separately. In the exemplary precision pod embodiments for a vaporizer, less vapor is required to inhale for a given dose of ne or a cannabinoid in a solid or semi solid format, as compared to vaping tobacco and cannabis together or tely since the active ingredients are much more concentrated in solid or semi-solid formats (e.g., crystalline compounds) included in precision pods. For example, e-liquids of e-cigarettes contain less than 6 percent nicotine (more than about 95 percent nonactive ingredients), and e-liquids of medical vape pens typically contain concentrates of less than 50% cannabinoids which are not crystalline. In contrast, precision pods either do not include any carriers such as propylene glycol or glycerin, or they contain just enough to mimic the moisture levels found in tobacco products or cannabis buds (about 10 to about 17 percent). The result is that ready-to-vape crystalline blends of compounds in precision pods are less l to the lungs since the active ingredients are much more concentrated resulting in less vapor ed to be inhaled for a given dose of nicotine or a given dose of a cannabinoid.

Propylene glycol and vegetable glycerin are designated, G enerally Recognized As Safe (GRAS) by the FDA for ion as food ves, but not for inhalation; however, even though using e-cigarettes is widely ed to be less harmful than smoking cigarettes (since smoke is not produced and inhaled), there is insufficient long-term data for inhaling large amounts of propylene glycol or vegetable glycerin from e-cigarettes. Vaping a highly pure crystalline nicotine salt with blends of crystalline cannabinoid acid formulations, for example, without any propylene glycol or glycerin or with low s of these carriers (e.g., 5-15 percent by weight of the total blend in the precision pod), results in less mainstream vapor which is less harmful to the lungs, as ed to vaping e-liquids containing a very large proportion of propylene glycol and/or glycerin (e.g., 90%) or vaping whole cannabis flowers or vaping less concentrated forms of cannabinoids.

Likewise, and for those who prefer to smoke and not vape, to-smoke precision pods allow smokers to inhale smoke from highly pure forms of cannabinoids and nicotine. Ready-to-smoke precision pods comprising blends of solid or semi solid crystalline cannabinoid acids (e.g., CBDA and/or THCA) and a salt of ne (with or without es, flavors, and/or other additives) contained in the compartment of a precision pod and smoked in a pipe or bowl result in a significant reduction of smoke generated and inhaled for a given level of a cannabinoid and for a given level of nicotine, as compared to smoking blunts, spliffs, or factorymade cigarettes comprising cannabinoids. Since tobacco-related diseases are dose dependent on the cumulative level of tobacco smoke, reducing smoke intake reduces harm. Indeed, the more non-tobacco material (e.g., cannabinoids) in the filler of a conventional, factory-made tte, the more likely smokers are to compensate for the reduced levels of nicotine including taking larger puffs, more puffs per cigarette, or more cigarettes per day. A conventional cigarette comprised of any significant portion of cannabinoids in the filler may in fact increase harm to the smoker since a portion of the tobacco, and therefore nicotine, is being reduced. It would be impossible to reduce nicotine levels of a conventional cigarette to levels of a very low nicotine cigarette, in which compensation does not occur, by replacing 80 to 90 percent of the tobacco with cannabinoids since at that point, the cigarette would not function.

Ready-to-smoke precision pods allow the smoker to e the same ne satisfaction with significantly less smoke, and importantly, there are no carcinogenic tobaccospecific nitrosamines (TSNAs) and other tobacco-related compounds that result from smoking blunts, spliffs, or factory-made cigarettes comprising cannabinoids. If a form of synthetic nicotine is utilized, the ion pod is 100 percent tobacco free. In on to being less harmful by reducing smoke exposure, as compared to smoking blunts, s or other smoking products such as factory-made cigarettes comprising cannabinoids, ready-to-smoke precision pods comprised of crystalline HC ate the guesswork as to the type and magnitude of cating s for a given level and ratio of blended compounds since the formulations are consistent due to their purity levels. Flavors, terpenes and other additives, or constituents such as plant constituents (e.g., minimal amounts of very low THC is) may also be incorporated into precision pod formulations at minimal levels.

As shown in the exemplary embodiment of , a precision pod 29 in the shape of a hexagonal prism ses a blend of a nicotine salt (which may comprise any single or combination of the foregoing listed nicotine salts), crystalline THCA, crystalline CBDA and menthol ls within the compartment of the precision pod 29. Appropriate levels of ameliorators are added to the blend to smooth out the smoke and remove harshness, and propylene glycol and/or glycerin may also be included so that the blend has the appropriate moisture level. n about 12 and about 14 percent is the ideal re level for tobacco filler and cannabis flowers. T he moisture level of formulations of ready-to-smoke ion pods depends on many factors including the boiling point temperature and amount of each compound (and any plant constituents) in the formulation, and the boiling point and total amount of the blend. Different formulations may have different moisture levels. These compounds have been blended together and are in a solid or semi-solid form. Precision pods may comprise two or more vents. The precision pod 29 in comprises many vents (only one is labeled). A precision pod’s vents are for ventilation of inbound air into the compartment and outbound smoke or vapor out of the compartment for inhalation.

Each ready-to-vape or ready-to-smoke precision pod may comprise two or more compounds ed from the group consisting of nicotine, anatabine, anabasine, flavor, Δ9- tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA), cannabichromenenic acid , cannabigerolic acid (CBGA), cannabigerovarinic acid (CBGVA), tetrahydrocanabivarinic acid (THCVA), cannabidivarinic acid (CBDVA), cannabichromevarinic acid (CBCVA), myrcene, caryophyllene, pinene, limonene and/or humulene. Each ready-to-vape or to-smoke ion pod may comprise at least the following amounts of each of the entioned compounds: 0.10 mg, 0.20 mg, 0.30 mg, 0.40 mg, 0.50 mg, 0.60 mg, 0.70 mg, 0.80 mg, 0.90 mg, 1.0 mg, 1.1 mg 1.2 mg, 1.3 mg, 1.4 mg, 1.5 mg, 1.6 mg, 1.7 mg, 1.8 mg, 1.9 mg, 2 mg, 3 mg, 4 mg, 5 mg, 6 mg, 7 mg, 8 mg, 9 mg, 10 mg, 11 mg, 12 mg, 13 mg, 14 mg, 15 mg, 16 mg, 17 mg, 18 mg, 19 mg, 20 mg, 21 mg, 22 mg, 23 mg, 24 mg, 25 mg, 26 mg, 27 mg, 28 mg, 29 mg, 30 mg, 31 mg, 32 mg, 33 mg, 34 mg, 35 mg, 36 mg, 37 mg, 38 mg, 39 mg, 40 mg, 41 mg, 42 mg, 43 mg, 44 mg, 45 mg, 46 mg, 47 mg, 48 mg, 49 mg, 50 mg, 51 mg, 52 mg, 53 mg, 54 mg, 55 mg, 56 mg, 57 mg, 58 mg, 59 mg, 60 mg, 61 mg, 62 mg, 63 mg, 64 mg, 65 mg 66 mg, 67 mg, 68 mg, 69 mg, 70 mg, 71 mg, 72 mg, 73 mg, 74 mg, 75 mg 76 mg, 77 mg, 78 mg, 79 mg, 80 mg, 81 mg, 82 mg, 83 mg, 84 mg, 85 mg, 86 mg, 87 mg, 88 mg, 89 mg, 90 mg, 91 mg, 92 mg, 93 mg, 94 mg, 95 mg, 96 mg, 97 mg, 98 mg, 99 mg, 100 mg, 110 mg, 120 mg, 130 mg, 140 mg, 150 mg, 160 mg, 170 mg, 180 mg 190 mg, 200 mg, 250 mg, 300 mg, et cetera. For example, a precision pod may comprise at least 10 mg CBDA, at least 5 mg nicotine and at least 5 mg menthol. As a smoking cessation treatment or to assist tioning s to a tobacco heating product or e-cigarettes, as sed in U.S. Patent Application No. 16/047,948, any of the entioned amounts (i.e., at least 0.10 mg to at least 300 mg) of low nicotine tobacco and/or very low THC cannabis may be included in precision pods along with at least one of the aforementioned compounds for ready-to-vape or ready-to-smoke precision pods.

In some exemplary ments, a precision pod may comprise any of the aforementioned amounts (i.e., at least 0.10 mg through at least 300 mg) of nicotine, anatabine or anabasine not extracted from a ana plant; that is synthesized nicotine, anatabine or anabasine, and a precision pod may comprise any of the aforementioned amounts (i.e., at least 0.10 mg through at least 300 mg) of two or more of the following cannabinoid acids: THCA, CBDA, CBCA, CBGA, THCVA, CBDVA, CBCVA and CBGVA that are synthesized, that is, produced outside a Cannabis plant. In other exemplary embodiments, any of the aforementioned amounts (i.e., at least 0.10 mg through at least 300 mg) of conventional tobacco, low nicotine tobacco, conventional cannabis (i.e., marijuana) and/or very low THC cannabis may be included in ready-to-vape or ready-to-smoke precision pods along with at least one of the following compounds: ne, anatabine, ine, flavor, THCA, CBDA, CBCA, CBGA, THCVA, CBDVA, CBCVA and CBGVA, myrcene, caryophyllene, pinene, limonene and/or humulene.

In some exemplary embodiments, ready-to-vape or ready-to-smoke precision pods each comprises at least 5 mg of tobacco (conventional or very low nicotine) and/or at least 5 mg of cannabis (marijuana or very low THC is) and at least 2 mg of one or more of the aforementioned compounds such as THCVA (Tetrahydrocanabivarinic acid). For ready-to-vape or ready-to-smoke ion pods (and onserts or precision rods) herein, low nicotine tobacco means tobacco with a nicotine content equal to or less than 3 mg/g, and very low THC cannabis means cannabis with a collective THCA/THC content equal to or less than 3 mg/g.

Precision pods may be any size or shape including those designed for a ic model of vaporizer, pipe, bowl or bong. The precision pod is configured for the oven chamber of a vaporizer or the tobacco or cannabis chamber of a pipe, bowl or bong. Examples of suitable materials of rigid precision pods include but are not limited to fused quartz or silica, ceramics including non-toxic ultra -high-temperature ceramics, and any metal and preferably a non-toxic metal or metal alloy such as titanium and food-grade stainless steel; however, any material may be utilized for ion pods whether configured for a vaporizer or a pipe, bowl or bong. The material utilized for a vaporizer may depend on the capabilities or temperature ranges of a zer since different als including metals heat up at ent rates. In some exemplary embodiments, a ion pod is configured for a specific model of vaporizer already on the market or a precision pod and a zer are configured for one another during the product development phase of a newly designed zer. In other exemplary embodiments, generic precision pods are configured for multiple types of smoking products or multiple types of vaporizers.

For precision pods configured for smoking products, materials that do not result in combustion or partial tion are preferred; however, those materials that do result in combustion may also be utilized and comprised of paper-like als like reconstituted tobacco or other cellulosic materials like those produced from hemp. These types of less rigid precision pods are useful for low doses of compounds. Likewise, for precision pods configured for vaporizers, it is preferred that only the contents in the compartment of the precision pod should be transferred to the mainstream vapor, not compounds or tuents of the precision pod itself.

One of the main advantages of disposable ready-to-smoke or ready-to-vape precision pods, whether rigid or not rigid, is the convenience of the precise blends of desired compounds in exact ratios; however in other exemplary embodiments, precision pods may be reusable in which case there may be an access panel that opens and closes with a fastener to provide access for removing spent material and adding fresh compounds. There may be legs at the bottom of a precision pod so the air vents at the bottom of the oven chamber of a vaporizer or the draught hole in the chamber in bowl, pipe or bong is not blocked by the floor of the precision pod. In some exemplary embodiments of ready-to-vape precision pods, the vents at the bottom of the precision pod are configured so that they exactly line up with the vents at the bottom of the oven chamber in a vaporizer. In other exemplary embodiments of ready -to-smoke precision pods, the vent(s) at the bottom of the precision pod are configured so that they exactly line up with the t hole of the chamber in a bowl, pipe or bong. There may be one or more s within the compartment of a precision pod so that the compounds and any constituents are not resting on the floor of the compartment. This depends on the type of compounds in a ion pod and their boiling points, the amount of total nds in the precision pod, whether there is any plant al in the precision pod and whether a ion pod is ically made for a specific model of vaporizer or smoking product.

As shown in , a to-smoke precision pod 31 has been placed within a bowl 32 and may be used with other smoking products such as a pipe or bong. The precision pod comprises the exact blend of compounds and constituents desired and allows the blend in the compartment of the precision pod to heat, melt and burn evenly. An exact blend of crystalline ne, crystalline cannabinoid acids (e.g., THCA and CBDA), menthol and ameliorators, for example, ically reduces the amount of smoke inhaled for a given dose of nicotine or a given dose of a cannabinoid, as compared to smoking spliffs, bluffs or factory-made cigarettes that include cannabinoids. This is due to the higher concentration of nicotine in this formulation which causes smokers to compensate (i.e., titrate down). Since some embodiments of ready-to-smoke ion pods do not include cannabis plant al (other than crystalline cannabinoids) or tobacco plant material (other than a crystalline nicotine salt), less smoke and ‘tar’ are ed and d resulting in a less harmful product. In other exemplary embodiments, precision pods do not comprise of any compounds or constituents extracted or derived from tobacco; however, they include synthetic nicotine which results in o-free and nicotine-free precision pod blends.

As shown in , a vaporizer 33 is being held and the oven cover 34 has been removed from the top of the vaporizer 33. The oven chamber 35 is exposed which is where a ready-to-vape precision pod may be placed so that a precise amount of two or more compounds or one or more compounds plus plant material(s) such as cannabis may be vaped. As shown in , the vaporizer 33 now includes an exemplary embodiment of a ready-to-vape-precision pod 36 which has been placed in the vaporizer’s oven chamber 35 where it is g. The ready-to-vape precision pod includes an exact formulation of compounds within its compartment and the precision pod is ready to be used right out of the packaging. Four legs 37 are included on the precision pod to increase air and vapor flow at the bottom of the precision pod. Upon the zer’s power being turned on, the oven chamber 35 heats up and the contents of the precision pod, which include at least 5 mg of a crystalline salt of nicotine, at least 5 mg of a lline cannabidiolic acid (CBDA) and ameliorators ( such as one or more food grade acids like citric acid to smooth out the vapor and remove harshness). This solid or semi solid formulation does not contain, or transfer to the mainstream vapor, carcinogenic tobacco compounds such as TSNAs. The to-vape precision pod 36 of reduces ream vapor exposure, as compared to vaping nicotine containing e-cigarettes, since there is a much greater concentration of ne in the ream vapor from the precision pod than from e-liquids so the person vaping the ion pod compensates accordingly by inhaling less vapor. Likewise, as compared to a tobacco heating product, there is also a greater concentration of nicotine in the mainstream vapor from the precision pod so less mainstream vapor needs to be inhaled per 1 mg of nicotine desired, which is in addition to the advantage that the mainstream vapor of the precision pod does not contain tobacco carcinogens since the precision pod does not contain tobacco.

Of course, each of the three products: ready-to-vape precision pods, e-cigarettes, and tobacco heating products, results in reduced harm, as compared to combustible ttes (with or without added cannabinoids), since nothing is being burned in these three ts, there is no tobacco smoke produced which contains thousands of compounds ing dozens of carcinogens. Another incidental advantage of ready-to-vape-precision pods is that they keep vaporizers cleaner, as compared to using vaporizers without precision pods, since much of the remaining spent material is kept in the precision pod and does seep into the vents at the bottom of the vaporizer’s oven chamber, which results in the vaporizer having to be cleaned less frequently.

In some exemplary embodiments, precision pods include at least 5 mg of low nicotine tobacco and/or at least 5 mg of very low THC cannabis to assist smokers to quit tobacco and nicotine products ther or to switch to a less l product such as e-cigarettes, tobacco heating products or precision pods. See U.S. Patent Application No. 16/047,948 for methods and s types of products to transition conventional cigarette smokers to less harmful products. Precision pods that comprise low nicotine tobacco and/or very low THC cannabis may further comprise at least 2 mg of one or more compounds selected from the group consisting of THCA, CBDA, CBCA, CBGA, THCVA, CBDVA, CBCVA, CBGVA, ne, anatabine, ine, myrcene, caryophyllene, pinene, ne and humulene. For example, a precision pod comprising at least 50 mg of low nicotine tobacco, at least 50 mg of very low THC cannabis, and at least 5 mg of CBDA, results in much less smoke exposure than a very low nicotine cigarette comprising about 600 mg of low nicotine tobacco.

For formulations of precision pods comprising intoxicating compounds such as THCA/THC, the type and magnitude of intoxicating effects are predictable from using precision pods with precisely quantified ready-to-vape or ready-to-smoke blends. For example, blends of crystalline or near crystalline inoid acids, including Δ9-tetrahydrocannabinolic acid (THCA), and a crystalline or near crystalline salt(s) of nicotine (with or without terpenes, flavors, and/or other additives, or constituents such as plant constituents), are advantageous for dual users of tobacco and recreational marijuana in terms of re to tobacco toxins and ience.

Ready-to-vape precision pods comprising blends of crystalline or near crystalline inoid acids, including cannabidiolic acid (CBDA), are advantageous for those who seek relief from pain and do not desire to inhale the voluminous vapor from vape pens.

As potency of cannabis concentrates increases, accurate dosing gets more ult, and THC effects can be quite variable. Consuming cannabis concentrates such as crystalline cannabinoids, wax, budder, oil, shatter or sap, is typically accomplished by ‘dabbing,’ which is positioning the concentrate on an extremely hot metal object such as a nail that is heated by a blowtorch or the like, and then the vapor is inhaled. Besides being a ous and cumbersome procedure, it is extremely difficult to obtain the correct amount of concentrate which often leads to over-consumption and unpleasant s. The ial safety issues and potential intoxicating effects of the THC concoction are often unknown, and the actual intoxicating effects may vary widely including from one cannabis-concentrate production batch to another. The THC percentage may not be known or accurate and the ‘entourage effect’ from the interactions of the various cannabinoids and impurities is difficult to predict. These downsides also occur with concentrates used in vaporizers.

Benefits of ready-to-smoke and ready-to-vape precision pods comprising one or more crystalline inoid acids, as compared to dabbing, is that each of the one or more crystalline cannabinoid acids comprise an exact measured dose of the cannabinoid acid (up to about to 99% pure) that is ready to smoke or vape without preparation and the precision pod results in virtually consistent effects for the same person. In some exemplary embodiments of precision pods, the entioned amounts of THCA in milligrams, along with the purity level of THCA (THCA weight divided by total weight of the nds and any additives or constituents in the precision pod), is clearly conveyed on the packaging such as at least about 80%, at least about 85%, at least about 90%, at least about 93%, at least about 95%, at least about 97%, at least about 98%, or at least about 99%, so that end users know what effects to expect for a given THCA content and THCA ratio of the blend. For example, the predictability and consistency of the effects of a precision pod which includes 5 mg of a salt of nicotine, 50 mg of crystalline THCA and 20 mg of crystalline CBDA, 17.5 mg of very low THC cannabis (> 0.30% THCA) and 7.5 mg of a carrier and/or rator is quite beneficial for cannabis users who desire exact, potent and tent effects along with concurrent THC/nicotine effects. The THC purity level of this 100 mg precision pod blend is 50% (50 mg/100 mg). The nicotine/THC ratio is 10%, and the C ratio is 40%. A s ed to dabbing or vaping other concentrates in which the cannabinoid ratios and THC levels are either not known or not consistent in every production batch, ready-to-vape and ready-to-smoke precision pods comprising lline cannabinoids are beneficial for cannabis users who desire tency with concentrates and do not want to consume too much THC at once. The purity of y measured quantities of and ratios of crystalline cannabinoids and forms of crystalline nicotine in ation with precision pods not only results in consistency and reduced harm, the convenience of ready-to-smoke and tovape precision pods is also advantageous over dabbing or using le vaping devices.

The advantages of precision pods readily become apparent for ming the biological constraints on the cannabis plant of intrinsically producing certain minor cannabinoids and certain ratios of cannabinoids. For example, Tetrahydrocanabivarinic acid (THCVA) which decarboxylates to Tetrahydrocannabivarin (THCV), is a minor cannabinoid found at trace levels in most cannabis strains. Sativa strains tend to have higher THCVA content. THCV may be an important appetite suppressant, therapeutic to reduce panic attacks, and therapeutic for the treatment of ne dependence and possibly other types of dependence. Due to THCV being a minor cannabinoid, it would be extremely difficult if not impossible to vape or smoke flowers from a cannabis strain which comprises a THCVA to THCA ratio of at least 3/2 or a THCVA to CBDA ratio of at least 3/2. In some exemplary embodiments, THCVA is extracted and isolated for use in precision pods (or onserts or precision rods) comprising a THCVA to THCA ratio of at least 3/2.

In other exemplary embodiments, THCVA is extracted and isolated for use in precision pods (or onserts or precision rods) comprising a THCVA to CBDA ratio of at least 3/2.

Tetrahydrocanabivarinic acid (THCVA) may be sized and utilized in precision pods, precision rods and s.

It will be appreciated that any exemplary ment herein may be automated with a machine whether it is a purely mechanical machine, table-top machine, or more substantial electrical type of e. For example, in some exemplary embodiments, es may provide adjunct nicotine sources (e.g., precision rods) to multiple cigarettes at once such as an entire pack of twenty cigarettes.

Certain precision rods, onserts, ready-to-vape precision pods and ready-to-smoke precision pods that comprise crystalline alkaloids may not be considered tobacco products in some jurisdictions since, among other reasons, they do not contain tobacco other than alkaloids, which may or may not be derived from tobacco plants. The alkaloids of these articl es may be synthesized so that no ingredients whatsoever are from tobacco plants. se, in some exemplary embodiments, the cannabinoids used in onserts, precision rods or precision pods may be sized and produced outside of a cannabis plant. In other exemplary embodiments, synthetic ids and synthetic cannabinoids are blended resulting in formulations used in onserts, precision rods or ion pods which do not n any Nicotiana or Cannabis plant material.

The

Claims (25)

CLAIMS defining the present ion are as follows:

1. A disposable to-vape precision pod for use with a vaporizer as a smoking cessation ent, to assist transitioning smokers to e-cigarettes or a tobacco heating product, or to quit tobacco and nicotine products altogether, the ready-to-vape precision pod comprising: one or more compounds equaling at least 2 mg selected from the group consisting of nicotine, anatabine, anabasine, flavor, Δ9-tetrahydrocannabinolic acid (THCA), Cannabidiolic acid , ichromenenic acid (CBCA), Cannabigerolic acid (CBGA), Cannabigerovarinic acid (CBGVA), Tetrahydrocanabivarinic acid (THCVA), Cannabidivarinic acid (CBDVA), Cannabichromevarinic acid (CBCVA), myrcene, caryophyllene, pinene, limonene and humulene; at least 5 mg of very low THC cannabis; at least 5 mg of low nicotine tobacco; a compartment that houses the one or more compounds, the very low THC cannabis and the low nicotine o; and one or more vents for ation of air and vapor into and out of the compartment, wherein the ready-to-vape precision pod is configured for an oven chamber of the vaporizer for placement into the oven chamber, wherein the at least 5 mg very low THC cannabis comprises a collective THCA/THC content of equal to or less than 3 mg/g, and wherein the at least 5 mg low nicotine tobacco comprises a nicotine content of equal to or less than 3 mg/g.

2. The ready-to-vape ion pod of claim 1, wherein the one or more compounds is a flavor comprising menthol.

3. The ready-to-vape precision pod of claim 1, wherein the one or more compounds is Tetrahydrocanabivarinic acid (THCVA).

4. The ready-to-vape precision pod of claim 1, n the one or more compounds is anatabine.

5. The ready-to-vape precision pod of claim 1, wherein the one or more compounds is Cannabidiolic acid (CBDA).

6. The ready-to-vape precision pod of claim 5, further comprising at least 2 mg of cytisinicline.

7. A ready-to-vape precision pod for use with a vaporizer configured to te vapor from dry herbs or plant extracts to assist transitioning tte smokers to e-cigarettes or a tobacco heating product, for use as a smoking cessation ent, or to quit tobacco and nicotine products altogether, the to-vape precision pod comprising: one or more compounds equaling at least 2 mg selected from the group consisting of nicotine, anatabine, anabasine, flavor, THCA/THC, CBDA/CBD, CBCA/CBC, CBGA/CBG, THCVA/THCV, CBDVA/CBDV, CBCVA/CBCV, CBGVA/CBGV, myrcene, caryophyllene, pinene, limonene and ne; at least 5 mg of Cannabis; at least 5 mg of low nicotine tobacco; a tment that houses the one or more compounds, the Cannabis and the low nicotine tobacco; and one or more vents for ventilation of air and vapor into and out of the tment, wherein the at least 5 mg low nicotine tobacco comprises a nicotine content of equal to or less than 3 mg/g.

8. The ready-to-vape precision pod of claim 7, wherein the at least 5 mg of Cannabis comprises very low THC Cannabis.

9. The ready-to-vape precision pod of claim 8, wherein the at least 5 mg very low THC Cannabis ses a collective THCA/THC content of equal to or less than 3 mg/g.

10. The ready-to-vape precision pod of claim 7, 8 or 9, wherein the one or more compounds is anatabine.

11. The ready-to-vape precision pod of claim 7, 8 or 9, wherein the one or more compounds is anabasine.

12. The ready-to-vape precision pod of claim 7, 8 or 9, wherein the one or more compounds is a flavor comprising l.

13. The ready-to-vape precision pod of claim 7, 8 or 9, wherein the one or more compounds is CBCA/CBC.

14. The ready-to-vape precision pod of claim 7, 8 or 9, wherein the one or more nds is CBCVA/CBCV.

15. The ready-to-vape precision pod of claim 7, 8 or 9, wherein the one or more compounds is CBDA/CBD.

16. The ready-to-vape precision pod of claim 7, 8 or 9, wherein the one or more compounds is CBDVA/CBDV.

17. The ready-to-vape precision pod of claim 7, 8 or 9, wherein the one or more compounds is CBGA/CBG.

18. The ready-to-vape precision pod of claim 7, 8 or 9, wherein the one or more compounds is CBGVA/CBGV.

19. The ready-to-vape precision pod of claim 7, 8 or 9, wherein the one or more compounds is THCVA/THCV.

20. A to-smoke precision pod for use with a smoking product for inhalation of mainstream smoke as a smoking cessation treatment, to assist tioning smokers to e-cigarettes or a tobacco g product, or to quit tobacco and nicotine ts altogether, the ready-tosmoke precision pod comprising: one or more compounds equaling at least 2 mg selected from the group consisting of nicotine, anatabine, anabasine, , THCA/THC, CBDA/CBD, BC, BG, THCVA/THCV, CBDVA/CBDV, CBCVA/CBCV, CBGVA/CBGV, myrcene, caryophyllene, pinene, limonene and humulene; at least 5 mg of low nicotine tobacco; at least 5 mg of very low THC Cannabis; a compartment that houses the one or more compounds, the low nicotine tobacco and very low THC cannabis; and one or more vents for ventilation of air and smoke into and out of the compartment, wherein the smoking product comprises a pipe, bowl or bong, wherein the ready-to-smoke ion pod is configured for a tobacco or Cannabis chamber of a pipe, bowl or bong, wherein the at least 5 mg very low THC is comprises a collective THCA/THC content of equal to or less than 3 mg/g, and wherein the at least 5 mg low nicotine tobacco comprises a nicotine content of equal to or less than 3 mg/g.

21. The ready-to-smoke precision pod of claim 20, wherein the one or more compounds is anabasine.

22. The ready-to-smoke precision pod of claim 20, wherein the one or more compounds is anatabine.

23. The ready-to-smoke ion pod of claim 20, wherein the one or more nds is a flavor comprising menthol.

24. The ready-to-smoke precision pod of claim 20, wherein the one or more compounds is THCVA/THCV.

25. The to-smoke precision pod of claim 20, wherein the one or more compounds is CBDA/CBD. WO 50682 WO 50682 WO 50682