KR20220056246A - Articles and formulations for smoking products and vaporizers - Google Patents

Abstract

Methods and apparatus for personalization of tobacco and hemp smoking products, including formulations for precision rods and precision pods, as well as on-sert, precision rods and precision pods for reduced hazard products, particularly for those who simultaneously smoke or vape tobacco and marijuana, as well as vaporizers A method and apparatus for formulating a nicotine salt in crystalline form, and one or more cannabinoids in crystalline form, for a precision pod for use in

Description

Articles and formulations for smoking products and vaporizers

The present disclosure relates to tobacco and hemp products.

[Cross-Reference to Related Applications]

This application claims priority to U.S. Patent Application No. 16/569,318, filed September 12, 2019 with the U.S. Patent and Trademark Office, the disclosure of which is incorporated herein by reference in its entirety.

Tobacco product manufacturers have the methods and know-how to produce products with a wide range of nicotine content and alkaloid profiles. For example, they can produce cigarettes ranging from approximately 0.20 mg of nicotine per cigarette to at least 30 mg per cigarette. Very low nicotine cigarettes and low tar-to-nicotine yield-ratio cigarettes are both useful for reducing tobacco harm for different purposes; The former is for completely quitting smoking and tobacco use or for converting smokers to smokeless tobacco products, the latter for smoking less. The methods and know-how of manufacturers of tobacco products include genetic engineering and plant breeding techniques to reduce or increase the nicotine content in tobacco plants. Nicotine can also be extracted from tobacco for the production of ultra-low nicotine cigarettes, or nicotine can be added for the production of low tar-to-nicotine yield-ratio cigarettes. See, for example, US Pat. Nos. 3,612,066, 9,738,622, 9,814,258 and 10,113,174, which describe these methods used by tobacco product manufacturers to make factory manufactured tobacco products. On the other hand, tobacco end users do not possess such methods or know-how capabilities; Nor do we have devices or alkaloids in suitable formulations for conveniently and economically adding alkaloids, cannabinoids, flavors, or other additives to their smoking products, including cigarettes, cigars, and marijuana cigarettes.

Alternatively, some people, including nonsmokers, smoke or vape tobacco and hemp at the same time, but the complementary and potentiating effects of the combination of the nicotine in tobacco and the cannabinoids in hemp because there is Whether tobacco or hemp is smoked or vaporized individually or simultaneously, inhaling the smoke or vapor is the most efficient and fastest way to experience the effects of these compounds. A major problem with smoking or vaping combinations of tobacco and hemp is that many non-nicotine and non-cannabinoid compounds must be inhaled along with the nicotine and cannabinoids. This is particularly the case when smoking a combination of tobacco and hemp, or cigarettes with any cannabinoids added, because in either case many carcinogenic tobacco compounds must be inhaled simultaneously with nicotine and cannabinoids. . Called the father of tobacco harm reduction, Michael Russell is famous for saying "People smoke for nicotine but they die from the tar." However, the use of tobacco in any form, including smokeless tobacco products, is not without risks because it is carcinogenic and includes N-Nitrosonornicotine (NNN), 4-N-Nitrosonomethyl Amino-1-(3-pyridyl)-1-butanone (4-N-Nitrosomethylamino-1-(3-pyridyl)-1-butanone, NNK), N-Nitrosoanatabine (N-Nitrosoanatabine, NAT) This is because tobacco contains tobacco-specific nitrosamines (TSNAs), including , and N-Nitrosoanabasine (NNA). Although U.S. Patent No. 10,369,178 discloses a tobacco product to which cannabinoids have been added, this disclosure in no way solves the problem of exposing smokers to many tobacco carcinogens, including TSNA, in order to enjoy the pleasurable effects of consuming nicotine and cannabinoids simultaneously. I never do that. Furthermore, this disclosure does not propose any device that facilitates consumers to modify their factory-made cigarettes.

Thus, it allows consumers (i) to conveniently, economically, and precisely personalize the nicotine, other alkaloid and/or flavor content of factory-made smoking products and (ii) to vape immediately without exposure to other tobacco compounds. Precise pods that are ready-to-vape and ready-to-smoke containing suitable formulations that allow you to enjoy the pleasurable complex effects of combinations of nicotine, cannabinoids and other compounds. product is needed

9-테트라하이드로카나비놀산(

9-tetrahydrocannabinolic acid, THCA), 카나비디올산(cannabidiolic acid, CBDA), 카나비크로멘산(cannabichromenenic acid, CBCA), 카나비게롤산(cannabigerolic acid, CBGA), 테트라하이드로카나비바린산(tetrahydrocanabivarinic acid, THCVA), 카나비디바린산(cannabidivarinic acid, CBDVA), 카나비크로메바린산(cannabichromevarinic acid, CBCVA), 카나비게로바린산(cannabigerovarinic acid, CBGVA), 미르센(myrcene), 카리오필렌(caryophyllene), 피넨(pinene), 리모넨(limonene) 및 휴뮬렌(humulene)으로 이루어진 군으로부터 선택된다.According to one embodiment of the present disclosure, an onsert is provided for applying one or more compounds on, around or within a smoking article for delivery to the mainstream smoke of the smoking article, the onsert comprising: a cellulosic wrapper; an adhesive disposed on a cellulosic wrapper for adhering the onsert to the product, and one or more compounds disposed on the cellulosic wrapper, wherein the one or more compounds individually equivalent to at least 1 mg are nicotine, anatabine, anabacin, flavor,

9-tetrahydrocannabinolic acid (

9-tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA), cannabichromenenic acid (CBCA), cannabigerolic acid (CBGA), tetrahydrocanabivarinic acid (THCVA) , cannabidivarinic acid (CBDVA), cannabichromevarinic acid (CBCVA), cannabigerovarinic acid (CBGVA), myrcene, caryophyllene, pinene ), limonene and humulene.

For onsert, the smoking product may be a cigarette and the one or more compounds may be nicotine.

In onsert, nicotine may include a nicotine salt.

For onsert, the smoking product may be a cigarette and the one or more compounds may be anatabine.

9-테트라하이드로카나비놀산(THCA)일 수 있다.For onsert, the smoking product may be a cigarette, and the one or more compounds

9-tetrahydrocannabinolic acid (THCA).

For onsert, the smoking product may be a cigarette and the one or more compounds may be cannabidioic acid (CBDA).

9-테트라하이드로카나비놀산(THCA) 및 카나비디올산(CBDA)일 수 있다.For onsert, the smoking product may be a cigarette, wherein the one or more compounds are collectively equivalent to at least 5 mg.

9-tetrahydrocannabinolic acid (THCA) and cannabidioic acid (CBDA).

For onsert, the smoking product may be a tobacco and the one or more compounds may be nicotine.

For onsert, the smoking product may be a tobacco and the one or more compounds may be anatabine.

9-테트라하이드로카나비놀산(THCA)일 수 있다.In the case of onsert, the smoking product may be a tobacco, and the one or more compounds

9-tetrahydrocannabinolic acid (THCA).

For onsert, the smoking product may be a tobacco and the one or more compounds may be cannabidioic acid (CBDA).

For onsert, the smoking product may be cannabis and the one or more compounds may be nicotine.

For onsert, the smoking product may be cannabis and the one or more compounds may be anatabine.

9-테트라하이드로카나비놀산(THCA)일 수 있다.In the case of onsert, the smoking product may be cannabis and one or more compounds may be

9-tetrahydrocannabinolic acid (THCA).

For onsert, the smoking product may be cannabis and the one or more compounds may be CBDA.

For onsert, the smoking product may be cannabis and the one or more compounds may collectively be THCA and CBDA equal to at least 5 mg.

For onsert, the smoking product may be a marijuana cigarette and the one or more compounds may be nicotine.

For onsert, the smoking product may be a marijuana cigarette and the one or more compounds may be anatabine.

In on-sert, the adhesive may be self-adhesive.

In on-sert, the adhesive may be moisture activated.

9-테트라하이드로카나비놀산(

9-tetrahydrocannabinolic acid, THCA), 카나비디올산(cannabidiolic acid, CBDA), 카나비크로멘산(cannabichromenenic acid, CBCA), 카나비게롤산(cannabigerolic acid, CBGA), 테트라하이드로카나비바린산(tetrahydrocanabivarinic acid, THCVA), 카나비디바린산(cannabidivarinic acid, CBDVA), 카나비크로메바린산(cannabichromevarinic acid, CBCVA), 카나비게로바린산(cannabigerovarinic acid, CBGVA), 미르센(myrcene), 카리오필렌(caryophyllene), 피넨(pinene), 리모넨(limonene) 및 휴뮬렌(humulene)으로 이루어진 군으로부터 선택되는 개별적으로 적어도 1 mg과 동등한 상기 하나 이상의 화합물, 및 상기 하나 이상의 화합물이 셀룰로오스 로드에 접착되거나 그 내부에 수용될 수 있는 350°C 미만의 점화 온도를 갖는 셀룰로오스 로드를 포함한다.According to one embodiment of the present disclosure, a precision rod is provided for inserting one or more compounds into a smoking article for delivery to mainstream smoke of the smoking article, the precision rod comprising: nicotine, anatabine, anabacin, flavor;

9-tetrahydrocannabinolic acid (

9-tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA), cannabichromenenic acid (CBCA), cannabigerolic acid (CBGA), tetrahydrocanabivarinic acid (THCVA) , cannabidivarinic acid (CBDVA), cannabichromevarinic acid (CBCVA), cannabigerovarinic acid (CBGVA), myrcene, caryophyllene, pinene ), at least one compound, individually equal to at least 1 mg selected from the group consisting of limonene and humulene, and 350° wherein the at least one compound can be adhered to or contained within a cellulose rod and a cellulosic rod having an ignition temperature of less than C.

For precision rods, the smoking product may be a cigarette and the one or more compounds may be nicotine.

In precision rods, the nicotine may be a nicotine salt.

9-테트라하이드로카나비놀산(THCA)일 수 있다.For precision rods, the smoking article may be a cigarette, and the one or more compounds may be

9-tetrahydrocannabinolic acid (THCA).

For precision rods, the smoking article may be a cigarette and the one or more compounds may be cannabidioic acid (CBDA).

9-테트라하이드로카나비놀산(THCA) 및 카나비디올산(CBDA)일 수 있다.For precision rods, the smoking article may be a cigarette, wherein the one or more compounds are collectively equivalent to at least 5 mg.

9-tetrahydrocannabinolic acid (THCA) and cannabidioic acid (CBDA).

For precision rods, the smoking product may be a marijuana cigarette and the one or more compounds may be nicotine.

For precision rods, the smoking article may be a cigarette and the one or more compounds may be anatabine.

9-테트라하이드로카나비놀산(

9-tetrahydrocannabinolic acid, THCA), 카나비디올산(cannabidiolic acid, CBDA), 카나비크로멘산(cannabichromenenic acid, CBCA), 카나비게롤산(cannabigerolic acid, CBGA), 테트라하이드로카나비바린산(tetrahydrocanabivarinic acid, THCVA), 카나비디바린산(cannabidivarinic acid, CBDVA), 카나비크로메바린산(cannabichromevarinic acid, CBCVA), 카나비게로바린산(cannabigerovarinic acid, CBGVA), 미르센(myrcene), 카리오필렌(caryophyllene), 피넨(pinene), 리모넨(limonene) 및 휴뮬렌(humulene)으로 이루어진 군으로부터 선택되는 개별적으로 적어도 1 mg과 동등한 상기 하나 이상의 화합물, 상기 하나 이상의 화합물을 수용하는 내부 챔버, 상기 하나 이상의 화합물이 배치될 수 있는 350°C 초과의 점화 온도를 갖는 상기 내부 챔버 주위의 난연성 강성 재료, 및 유입 공기를 상기 정밀 로드 내로 그리고 유출 연기를 상기 정밀 로드 밖으로 환기시키기 위한 적어도 하나의 통기구를 포함한다.According to one embodiment of the present disclosure, a precision rod is provided for inserting one or more compounds into a smoking article for delivery to mainstream smoke of the smoking article, the precision rod comprising: nicotine, anatabine, anabacin, flavor;

9-tetrahydrocannabinolic acid (

9-tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA), cannabichromenenic acid (CBCA), cannabigerolic acid (CBGA), tetrahydrocanabivarinic acid (THCVA) , cannabidivarinic acid (CBDVA), cannabichromevarinic acid (CBCVA), cannabigerovarinic acid (CBGVA), myrcene, caryophyllene, pinene ), limonene and humulene, individually equivalent to at least 1 mg selected from the group consisting of said one or more compounds, an inner chamber containing said one or more compounds, 350 in which said one or more compounds may be disposed a flame retardant rigid material around the inner chamber having an ignition temperature greater than °C, and at least one vent for venting inlet air into the precision rod and outflow smoke out of the precision rod.

For precision rods, the smoking product may be a cigarette and the one or more compounds may be nicotine.

In precision rods, the nicotine may be a nicotine salt.

9-테트라하이드로카나비놀산(THCA)일 수 있다.For precision rods, the smoking article may be a cigarette, and the one or more compounds may be

9-tetrahydrocannabinolic acid (THCA).

For precision rods, the smoking article may be a cigarette and the one or more compounds may be cannabidioic acid (CBDA).

9-테트라하이드로카나비놀산(THCA) 및 카나비디올산(CBDA)일 수 있다.For precision rods, the smoking article may be a cigarette, and the one or more compounds may be

9-tetrahydrocannabinolic acid (THCA) and cannabidioic acid (CBDA).

For precision rods, the smoking product may be a marijuana cigarette and the one or more compounds may be nicotine.

9-테트라하이드로카나비놀산(

9-tetrahydrocannabinolic acid, THCA), 카나비디올산(cannabidiolic acid, CBDA), 카나비크로멘산(cannabichromenenic acid, CBCA), 카나비게롤산(cannabigerolic acid, CBGA), 테트라하이드로카나비바린산(tetrahydrocanabivarinic acid, THCVA), 카나비디바린산(cannabidivarinic acid, CBDVA), 카나비크로메바린산(cannabichromevarinic acid, CBCVA), 카나비게로바린산(cannabigerovarinic acid, CBGVA), 미르센(myrcene), 카리오필렌(caryophyllene), 피넨(pinene), 리모넨(limonene) 및 휴뮬렌(humulene)으로 이루어진 군으로부터 선택되는 적어도 1 mg과 동등한 2개 이상의 배합된 화합물 중 각각, 상기 2개 이상의 배합된 화합물을 수용하는 구획부, 및 유입 공기를 상기 구획부 내로 그리고 유출 연기를 상기 구획부 밖으로 환기시키기 위한 하나 이상의 통기구를 포함하고, 여기서 상기 즉시 베이핑 가능한 정밀 포드는 상기 기화기의 오븐 챔버 내로 배치되도록 구성될 수도 있다.According to one embodiment of the present disclosure, a ready-to-vapor precision pod for use with a vaporizer configured to generate vapor from a dried herbal or concentrated plant extract for simultaneous inhalation of two or more compounds is provided, , The ready-to-vape precision pods contain nicotine, anatabine, anabacin, flavor,

9-tetrahydrocannabinolic acid (

9-tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA), cannabichromenenic acid (CBCA), cannabigerolic acid (CBGA), tetrahydrocanabivarinic acid (THCVA) , cannabidivarinic acid (CBDVA), cannabichromevarinic acid (CBCVA), cannabigerovarinic acid (CBGVA), myrcene, caryophyllene, pinene ), each of two or more combined compounds equal to at least 1 mg selected from the group consisting of limonene and humulene; and one or more vents for venting effluent smoke into and out of the compartment, wherein the ready-to-vape precision pod may be configured for placement into an oven chamber of the vaporizer.

9-테트라하이드로카나비놀산(THCA)일 수 있다.In precision rods ready to vape, two or more compounded compounds are nicotine and

9-tetrahydrocannabinolic acid (THCA).

In a precision rod ready to vape, the nicotine may be a nicotine salt.

9-테트라하이드로카나비놀산(THCA), 및 카나비디올산(CBDA)일 수 있다.In precision rods ready to vape, two or more compounded compounds are nicotine,

9-tetrahydrocannabinolic acid (THCA), and cannabidioic acid (CBDA).

9-테트라하이드로카나비놀산(THCA), 카나비디올산(CBDA), 및 카나비크롬산(CBCA)일 수 있다.In precision rods ready to vape, two or more compounded compounds are nicotine,

9-tetrahydrocannabinolic acid (THCA), cannabidioic acid (CBDA), and cannabichromic acid (CBCA).

In a precision rod ready to vape, the two or more combined compounds may be nicotine and anatabine.

9-테트라하이드로카나비놀산(THCA)일 수 있다.In a precision rod ready to vape, two or more compounded compounds are anatabine and

9-tetrahydrocannabinolic acid (THCA).

In a precision rod ready to vape, the two or more compounded compounds may be anatabine and cannabidioic acid (CBDA).

9-테트라하이드로카나비놀산(THCA), 및 카나비디올산(CBDA)일 수 있다.In precision rods ready for vaping, two or more compounded compounds are anatabine,

9-tetrahydrocannabinolic acid (THCA), and cannabidioic acid (CBDA).

9-테트라하이드로카나비놀산(

9-tetrahydrocannabinolic acid, THCA), 카나비디올산(cannabidiolic acid, CBDA), 카나비크로멘산(cannabichromenenic acid, CBCA), 카나비게롤산(cannabigerolic acid, CBGA), 테트라하이드로카나비바린산(tetrahydrocanabivarinic acid, THCVA), 카나비디바린산(cannabidivarinic acid, CBDVA), 카나비크로메바린산(cannabichromevarinic acid, CBCVA), 카나비게로바린산(cannabigerovarinic acid, CBGVA), 미르센(myrcene), 카리오필렌(caryophyllene), 피넨(pinene), 리모넨(limonene) 및 휴뮬렌(humulene)으로 이루어진 군으로부터 선택되는 적어도 1 mg과 동등한 하나 이상의 화합물, 적어도 5 mg과 동등한 마리화나, 상기 하나 이상의 화합물 및 상기 마리화나를 수용하는 구획부, 및 유입 공기를 상기 구획부 내로 그리고 유출 연기를 상기 구획부 밖으로 환기시키기 위한 하나 이상의 통기구를 포함하고, 여기서 상기 즉시 베이핑 가능한 정밀 포드는 상기 기화기의 오븐 챔버 내로 배치되도록 구성될 수도 있다.According to one embodiment of the present disclosure, there is provided a ready-to-vape precision pod for use with a vaporizer, wherein the ready-to-vape precision pod comprises nicotine, anatabine, anabacin, flavor;

9-tetrahydrocannabinolic acid (

9-tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA), cannabichromenenic acid (CBCA), cannabigerolic acid (CBGA), tetrahydrocanabivarinic acid (THCVA) , cannabidivarinic acid (CBDVA), cannabichromevarinic acid (CBCVA), cannabigerovarinic acid (CBGVA), myrcene, caryophyllene, pinene ), at least one compound equal to at least 1 mg selected from the group consisting of limonene and humulene, marijuana equal to at least 5 mg, a compartment containing the at least one compound and the marijuana, and inlet air one or more vents for venting fumes into the compartment and out of the compartment, wherein the ready-to-vapor precision pod may be configured for placement into an oven chamber of the vaporizer.

In a ready-to-vape precision rod, the one or more compounds may be nicotine.

In a precision rod ready to vape, the one or more compounds may be tetrahydrocannabivaric acid (THCVA).

9-테트라하이드로카나비놀산(THCA)일 수 있다.In precision rods ready for vaping, one or more compounds

9-tetrahydrocannabinolic acid (THCA).

9-테트라하이드로카나비놀산(

9-tetrahydrocannabinolic acid, THCA), 카나비디올산(cannabidiolic acid, CBDA), 카나비크로멘산(cannabichromenenic acid, CBCA), 카나비게롤산(cannabigerolic acid, CBGA), 카나비게로바린산(cannabigerovarinic acid, CBGVA), 테트라하이드로카나비바린산(tetrahydrocanabivarinic acid, THCVA), 카나비디바린산(cannabidivarinic acid, CBDVA), 카나비크로메바린산(cannabichromevarinic acid, CBCVA), 미르센(myrcene), 카리오필렌(caryophyllene), 피넨(pinene), 리모넨(limonene) 및 휴뮬렌(humulene)으로 이루어진 군으로부터 선택되는, 개별적으로 적어도 1 mg과 동등한 하나 이상의 화합물을 포함하고, 여기서 상기 플런저 기구는 상기 정밀 로드에 연결되고, 상기 정밀 로드는 하나 이상의 구멍 및 상기 하나 이상의 화합물을 수용하는 내부 챔버를 포함하고, 상기 플런저는 상기 정밀 로드 내의 하나 이상의 구멍을 통해 상기 화합물을 상기 흡연 제품의 주류연 내로 밀어냄으로써 상기 흡연 제품의 주류연에 상기 하나 이상의 화합물을 주입하도록 구성된다.According to one embodiment of the present disclosure, there is provided a flavor injection system for injecting one or more compounds into a smoking article for delivery of one or more compounds into the mainstream smoke of the smoking article, the flavor injection system comprising: a plunger device; Precision rods for insertion, and nicotine, anatabine, anabacin, flavor,

9-tetrahydrocannabinolic acid (

9-tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBA), cannabichromenenic acid (CBCA), cannabigerolic acid (CBGA), cannabigerovarinic acid (CBGVA), tetrahydrocanabivarinic acid (THCVA), cannabidivarinic acid (CBDVA), cannabichromevarinic acid (CBCVA), myrcene, caryophyllene, pinene ), limonene and humulene, each comprising at least one compound equivalent to at least 1 mg, wherein the plunger mechanism is connected to the precision rod, and the precision rod is one at least one orifice and an interior chamber receiving the one or more compounds, wherein the plunger pushes the compound through the one or more apertures in the precision rod into the mainstream smoke of the smoking article to thereby inject the one or more compounds into the mainstream smoke of the smoking article. configured to inject.

According to one embodiment of the present disclosure, there is provided a method of increasing the nicotine smoke yield of a factory-made cigarette, the method comprising providing an onsert comprising a salt of nicotine, wherein the onsert is in the factory-made cigarette. It may be for insertion.

According to one embodiment of the present disclosure, there is provided a method of increasing the nicotine smoke yield of a factory-made cigarette, the method comprising providing a precision rod comprising a salt of nicotine, wherein the precision rod is a factory-made cigarette It may be for insertion within.

According to one embodiment of the present disclosure, there is provided a nicotine fortified cigarette comprising a cigarette and a supplemental nicotine source coupled to or inserted into the cigarette, wherein the supplemental nicotine source increases the nicotine yield of the cigarette by at least 10%.

The auxiliary nicotine source may be an onsert connected to the cigarette.

The auxiliary nicotine source may be a precision rod inserted into the cigarette.

9-테트라하이드로카나비놀산(

9-tetrahydrocannabinolic acid, THCA), 카나비디올산(cannabidiolic acid, CBDA), 카나비크로멘산(cannabichromenenic acid, CBCA), 카나비게롤산(cannabigerolic acid, CBGA), 테트라하이드로카나비바린산(tetrahydrocanabivarinic acid, THCVA), 카나비디바린산(cannabidivarinic acid, CBDVA), 카나비크로메바린산(cannabichromevarinic acid, CBCVA), 카나비게로바린산(cannabigerovarinic acid, CBGVA), 미르센(myrcene), 카리오필렌(caryophyllene), 피넨(pinene), 리모넨(limonene) 및 휴뮬렌(humulene)으로 이루어진 군으로부터 선택되는, 적어도 1 mg과 동등한 2개 이상의 배합된 화합물 각각, 상기 2개 이상의 배합된 화합물을 수용하는 구획부, 및 유입 공기를 상기 구획부 내로 그리고 유출 연기를 상기 구획부 밖으로 환기시키기 위한 하나 이상의 통기구를 포함하고, 여기서 상기 흡연 제품은 파이프, 보울 또는 봉을 포함하고, 상기 즉시 흡연 가능한 정밀 포드는 상기 흡연 제품의 챔버 내에 배치되도록 구성될 수 있다.According to one embodiment of the present disclosure, there is provided a ready-to-smoker precision pod for use with a smoking article for simultaneous inhalation of two or more compounds, the ready-to-smoker precision pod comprising: nicotine, anatabine, anabacin, flavor ,

9-tetrahydrocannabinolic acid (

9-tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA), cannabichromenenic acid (CBCA), cannabigerolic acid (CBGA), tetrahydrocanabivarinic acid (THCVA) , cannabidivarinic acid (CBDVA), cannabichromevarinic acid (CBCVA), cannabigerovarinic acid (CBGVA), myrcene, caryophyllene, pinene ), each of two or more combined compounds equal to at least 1 mg selected from the group consisting of limonene and humulene; one or more vents for venting effluent smoke into and out of the compartment, wherein the smoking article comprises a pipe, bowl or rod, and wherein the ready-to-smoker precision pod is disposed within a chamber of the smoking article; can be configured.

9-테트라하이드로카나비놀산(THCA)일 수 있다.In a ready-to-smoker precision pod, two or more compounded compounds are nicotine and

9-tetrahydrocannabinolic acid (THCA).

In a ready-to-smoker precision pod, the nicotine may be a nicotine salt.

9-테트라하이드로카나비놀산(THCA), 및 카나비디올산(CBDA)일 수 있다.In a ready-to-smoker precision pod, two or more compounded compounds are nicotine,

9-tetrahydrocannabinolic acid (THCA), and cannabidioic acid (CBDA).

9-테트라하이드로카나비놀산(THCA), 카나비디올산(CBDA), 및 카나비크로멘산(CBCA)일 수 있다.In a ready-to-smoker precision pod, two or more compounded compounds are nicotine,

9-tetrahydrocannabinolic acid (THCA), cannabidioic acid (CBDA), and cannabichromenic acid (CBCA).

In a ready-to-smoker precision pod, the two or more combined compounds may be nicotine salt and anatabine.

9-테트라하이드로카나비놀산(THCA)일 수 있다.In ready-to-smoker precision pods, two or more compounded compounds are anatabine and

9-tetrahydrocannabinolic acid (THCA).

In a ready-to-smoker precision pod, the two or more combined compounds may be anatabine and cannabidioic acid (CBDA).

9-테트라하이드로카나비놀산(THCA), 및 카나비디올산(CBDA)일 수 있다.In ready-to-smoker precision pods, two or more compounded compounds are anatabine,

9-tetrahydrocannabinolic acid (THCA), and cannabidioic acid (CBDA).

9-테트라하이드로카나비놀산(

9-tetrahydrocannabinolic acid, THCA), 카나비디올산(cannabidiolic acid, CBDA), 카나비크로멘산(cannabichromenenic acid, CBCA), 카나비게롤산(cannabigerolic acid, CBGA), 테트라하이드로카나비바린산(tetrahydrocanabivarinic acid, THCVA), 카나비디바린산(cannabidivarinic acid, CBDVA), 카나비크로메바린산(cannabichromevarinic acid, CBCVA), 카나비게로바린산(cannabigerovarinic acid, CBGVA), 미르센(myrcene), 카리오필렌(caryophyllene), 피넨(pinene), 리모넨(limonene) 및 휴뮬렌(humulene)으로 이루어진 군으로부터 선택되는, 적어도 1 mg과 동등한 하나 이상의 화합물, 적어도 5 mg과 동등한 초저 니코틴 담배, 상기 하나 이상의 화합물 및 상기 초저 니코틴 담배를 수용하는 구획부, 및 유입 공기를 상기 구획부 내로 그리고 유출 연기를 상기 구획부 밖으로 환기시키기 위한 하나 이상의 통기구를 포함하고, 여기서 상기 흡연 제품은 파이프, 보울 또는 봉을 포함하고, 상기 초저 니코틴 담배는 3 mg/g 미만의 니코틴을 포함하고, 상기 즉시 흡연 가능한 정밀 포드는 상기 흡연 제품의 챔버 내에 배치되도록 구성될 수 있다.According to one embodiment of the present disclosure, there is provided a ready-to-smoker precision pod for use with a smoking article, the ready-to-smoker precision pod comprising: nicotine, anatabine, anabacin, a flavor;

9-tetrahydrocannabinolic acid (

9-tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA), cannabichromenenic acid (CBCA), cannabigerolic acid (CBGA), tetrahydrocanabivarinic acid (THCVA) , cannabidivarinic acid (CBDVA), cannabichromevarinic acid (CBCVA), cannabigerovarinic acid (CBGVA), myrcene, caryophyllene, pinene ) selected from the group consisting of limonene and humulene, at least one compound equal to at least 1 mg, an ultra-low nicotine cigarette equal to at least 5 mg, a compartment containing said one or more compounds and said ultra-low nicotine cigarette and one or more vents for venting inlet air into said compartment and effluent smoke out of said compartment, wherein said smoking product comprises a pipe, bowl or wand, and wherein said ultra-low nicotine cigarette is 3 mg/ The precision pod comprising less than g of nicotine, wherein the ready-to-smoker precision pod may be configured for placement within a chamber of the smoking article.

In the ready-to-smoker precision pod, the one or more compounds may be anatabine.

In the ready-to-smoker precision pod, the one or more compounds may be cannabidioic acid (CBDA).

The above and/or other aspects of the present disclosure will become more apparent by describing certain embodiments of the present disclosure with reference to the accompanying drawings, in which:
1A is a top view of an exemplary embodiment of a self-adhesive onsert for a cigarette;
1B is a perspective view of the self-adhesive onsert of FIG. 1A partially wrapped around a cigarette;
1C is a top view of the self-adhesive onsert of FIGS. 1A and 1B fully wrapped and glued around a cigarette;
1D is a top view of two exemplary embodiments of a self-adhesive onsert;
1E is a top view of an exemplary embodiment of a self-adhesive onsert;
1F is a top view of an exemplary embodiment of a self-adhesive onsert;
2A is a front exploded view of an exemplary embodiment of a precision rod and an assembled diagram of such an assembled precision rod;
2B is a perspective view of an exemplary embodiment of a precision rod, each having a different size;
2C is a top view of an exemplary embodiment of a precision rod inserted into a cigarette;
2D is a perspective view of an exemplary embodiment of a flavor injection system;
3A is a perspective view of an exemplary embodiment of a ready-to-smoker precision pod for a bowl or pipe;
3B is a perspective view of a smoking article, ie the ready-to-smoker precision pod of FIG. 3A placed in a bowl;
3C is a perspective view of a prior art vaporizer held with the oven cover removed while exposing the oven chamber; And
3D is a perspective view of an exemplary embodiment of a ready-to-vape precision pod placed within the oven chamber of the prior art vaporizer of FIG. 3C ;

The devices and formulations disclosed herein allow tobacco and hemp end users to conveniently, economically, and accurately personalize the content of nicotine, cannabinoids, flavoring and/or other additives in mainstream smoke from their smoking products, such as cigarettes, and mainstream smoke from vaporizers. This allows them to satisfy product and taste preferences regardless of manufacturer's product offerings in a given market. Ultra-low nicotine cigarettes are an important tool for converting smokers to e-cigarettes or tobacco heating products and for smokers to quit cigarettes and nicotine products completely; Thus, ultra-low nicotine cigarettes, along with e-cigarettes and tobacco heating products, have great potential for reducing tobacco harm. Because the rate of nicotine metabolism varies greatly among different groups of smokers, it is important for consumers, for example, to have the ability to slightly increase the nicotine content of their ultra-low nicotine cigarettes. The devices and formulations disclosed herein allow consumers to modify compounds in smoke from smoking products and precisely personalize compounds in vapors from vaporizers to their preferences.

When it comes to ultra-low nicotine cigarettes, these variations are more likely to happen while trying to quit smoking and nicotine products entirely, or switch to less harmful products such as e-cigarettes or ready-to-vape precision pods that contain a unique blend of compounds. A proportion of smokers could tolerate these cigarettes and only smoke them (without smoking any conventional cigarettes). See U.S. Patent Application No. 16/047,948 for methods of helping smokers switch to e-cigarettes or tobacco heating devices, or helping smokers quit smoking and nicotine completely, and various types of ultra-low nicotine cigarettes and other products.

In a phase 3 clinical trial published in the Journal of the American Medical Association to determine whether there were differences in biomarkers of smoke exposure between immediate and gradual reductions in the nicotine content of cigarettes, immediate reductions in nicotine were more It resulted in withdrawal symptoms, greater use of non-study conventional cigarettes, and higher dropout rates. For these study subjects, the immediate reduction to ultra-low nicotine cigarettes containing cigarettes with 0.4 mg/gram of nicotine (nicotine content per cigarette is approximately 0.3 mg) is likely to have resulted in the nicotine reduction being too low too quickly. See JAMA September 4, 2018, Vol. 320, No. 9, pp. 880-891. Some of these subjects who exited this study (and other studies using ultra-low nicotine cigarettes) were in a device that provided a supplemental nicotine source that was readily connected to their ultra-low nicotine cigarette and delivered into mainstream smoke if the smoker needed it. If they had access, they would likely have completed the study. Mainstream smoke is smoke that is inhaled, including smoke that exits the smoker's mouth as a result of the smoker smoking the smoking product or from the mouth end of a smoking product (eg, the filter end of a filter cigarette). The amount of nicotine provided for this purpose will be very small.

In a phase 2 clinical trial to investigate the effects of reduced nicotine cigarettes on smoking behavior, toxic exposure, dependence and withdrawal, there were three interventions: (i) 0.05 mg nicotine yield cigarette at 6 weeks (ultra-low nicotine content cigarette); (ii) a 0.3 mg nicotine yield cigarette (a low nicotine content cigarette approximately six times the nicotine content of an ultra-low nicotine cigarette), and (iii) a 4 mg nicotine candy. Although the churn rate was the highest for the nicotine candy arm at 48%, the 0.05 mg nicotine yield cigarette arm had the second highest churn rate at 40%, followed by the 0.3 mg nicotine yield cigarette arm at 25%. As withdrawal was considered a treatment failure, it would have been beneficial to reduce the dropout rate among those using ultra-low nicotine cigarettes, since the ultra-low nicotine cigarette arm had the highest post-treatment withdrawal rate of the three interventions. am. See Hatsukami et al. 2010, Addiction , 105(2):343-55. If people in the ultra-low nicotine cigarette arm of the study had access to a product that easily linked to their ultra-low nicotine cigarette to slightly increase nicotine in mainstream smoke as needed, the dropout rate would be lower and the discontinuation rate would be higher.

For smokers who are not interested in quitting smoking or switching to smoke-free products, increasing the nicotine content of conventional cigarettes increases the concentration of nicotine, resulting in a lower tar-to-nicotine yield-ratio and reduced smoke intake. Because cigarettes with a tar-to-nicotine yield ratio ('tar' machine yield divided by the nicotine machine yield, which may be the ISO method or other method) of about 8 or less are not currently sold by tobacco companies, their factory-manufactured conventional Consumers who increase the nicotine yield of cigarettes are advantageous for those who want to reduce the harm caused by their own smoking but cannot or do not want to quit smoking. Conventional cigarettes typically have a tar-to-nicotine yield ratio of 10 to 14 (e.g., a 'tar' yield of ISO 13 mg and a nicotine yield of 1 mg), which in this example, for every 1 mg of nicotine, This means that a smoker must inhale about 13 mg of 'tar'. It is important to note that although people smoke for nicotine, smoking-related diseases result from smoke containing 'tar'. Reducing the amount of smoke does less damage.

Due to the compensatory smoking behavior, compared to conventional cigarettes, exposure to harmful "tar" and gases is reduced by nicotine-fortified cigarettes (defined below), whereas exposure to nicotine remains approximately the same. . Although there are variations, smokers generally want approximately 1 mg of nicotine per cigarette, and any more nicotine per cigarette than the smoker would like would be an unpleasant experience. Smokers readily titrate smoke exposure when smoking nicotine-fortified cigarettes by taking smaller puffs and fewer puffs per cigarette. A conventional cigarette with improved nicotine yield in mainstream smoke by the Examples herein, compared to a conventional cigarette with no improved nicotine yield, provides the smoker with approximately 1 mg of nicotine per cigarette (or any one the smoker deems acceptable). of different cigarette amounts) is obtained more efficiently and causes the smoker to inhale less smoke. See, eg, Armitage et al., 1998, Psychopharmacology , 96:447-453; Fagerstrom 1982, Pharmacology , 77:164-167; Russell MA, Nicotine and Public Health , Chapter 15, American Public Health Organization, 2000; and Pandolfino 2005, Presentation on October 19, 2005 at Life Science Research Organization (LSRO), Reducing the Adverse Health Impact of Cigarettes on Smokers Who Will Not or Cannot Abstain Through Modification of Leaf Nicotine Content , available for download from the LSRO website.

A conventional cigarette with a tar-to-nicotine yield ratio of 13, now containing a sufficient supplemental nicotine source (eg, a precision rod comprising 18 mg of nicotine inserted into the cigarette), is less than 8 tar-to-nicotine Produces nicotine-fortified cigarettes with a yield ratio. As a result, smokers inhale significantly less smoke, including reducing 'tar'. The exact tar-to-nicotine yield ratio will depend on the characteristics for which the cigarette is fortified, including overall ventilation, filter type, level of additives, and the like.

8의 저 타르-대-니코틴 수율 비). 여기에는 시장에 나와 있는 기존 제품의 판매를 잠식하지 않기로 한 기업의 결정, 기술 또는 지식 재산권의 부족, 원자재의 고비용 또는 제한된 가용성, 제조업체가 제품을 판매하는 것을 금지하는 법률 또는 규정(소비자가 공장 제조 제품을 제조하거나 변형하지는 않음) 및/또는 시장 내 수요 수준이 제품을 출시하는 데 필요한 대규모 자본 지출(예: 필수 기계류)을 정당화하지 못할 수 있는 것이 포함된다.There are various reasons why a manufacturer does not offer a particular product to consumers despite the demand, such as:

low tar-to-nicotine yield ratio of 8). These include a company's decision not to undermine the sale of an existing product on the market, a lack of technical or intellectual property rights, the high cost or limited availability of raw materials, and laws or regulations that prohibit a manufacturer from selling a product (such as a consumer's does not manufacture or transform the product) and/or the level of demand in the market may not justify the large capital expenditures (eg, essential machinery) required to bring the product to market.

Each of the terms 'about' or 'approximately' is used herein to mean about, near, about, or within an area. When the term 'about' or 'approximately' is used in conjunction with a numerical value or range, it modifies that value or range by reasonably extending the boundaries above and below the numerical value presented.

An “alkaloid” is a group of nitrogenous compounds of general plant origin. For example, nicotine is the primary alkaloid found in commercial conventional cigarette tobacco, and, depending on the tobacco type (eg, xantho, Burley, and oriental) and cultivar (eg, K326), is found in tobacco leaves. It accounts for about 95% of the total alkaloids. Anatabine, nornicotine, anabasine and other alkaloids make up the remainder of the total alkaloids. The alkaloid profile, which is the percentage or contribution of each alkaloid to the total content of all alkaloids, differs depending on the tobacco type, tobacco variety, and tobacco brand filler. Depending on the tobacco type and variety, anatabine accounts for about 1% to about 4%, nornicotine accounts for about 1% to about 3%, and anabacin accounts for about 0.02% to about 0.4%. As used herein, 'nicotine', 'anatabine' and 'anavacine' may be extracted from any plant species, including any species of the genus Nicotiana , any one of these alkaloids being synthetic. Or it may be an analogue, or it may be prepared in the form of a salt of an organic acid. See, eg, Sisson et al., 1990, Beitragezur Tabakforschung International, Vol. 14, No. 6, June-July. Synthetic Nicotine, Nicotine Salt Derived from Synthetic Nicotine, Synthetic Anatabine, Synthetic Anatabine-derived Anatabine Salt, Synthetic Anabacin, Synthetic Anabacin-derived Anavacine Salt, Nicotine Analogs, Anatabine Analogs, Anabacin's Analogs, nicotine salts of organic acids, anatabine salts of organic acids and anabacin salts of organic acids are included herein in the meaning of nicotine, anatabine and anabacin, respectively. Nicotine salt, nicotine co-crystal, and nicotine salt co-crystal are all included within the meaning of nicotine herein, and any of these, including combinations, may be used in any of the embodiments herein.

Nicotine may be used in its form in the examples herein as a hygroscopic oily liquid, however, compared to the liquid form of nicotine, due to increased stability and cleaner and easier application for the end user, the end user may be either a solid or semi-solid. It is desirable in the embodiments herein to enhance the delivery of nicotine in the final tobacco product having nicotine as nicotine. Disclosed are, for example, nicotine salts, nicotine co-crystals and nicotine salt co-crystals in solid or semi-solid form, but for a consumer to incorporate nicotine as an auxiliary nicotine source into a finished tobacco product or a smoking product, such as a factory-made tobacco. See US Pat. No. 9,738,622, which does not disclose . Liquid forms of nicotine, such as e-liquid or e-juice, will inhibit ignition and combustion of smoking products to produce smoke, and the nicotine content may be too diluted to be a significant and effective supplemental nicotine source. In addition to being too bulky for the examples herein, these liquid and dilute forms of nicotine require too much aerosol to be generated for a given amount of nicotine, so for the vaporizer of some aerosol examples herein. will defeat the purpose. Regardless of smoke or vapor, the less inhaled the better, which is the advantage of concentrating nicotine and cannabinoids in the examples herein.

In addition to solid or semi-solid forms of nicotine, other compounds used in the formulations herein for onserts, precision rods, and precision pods are preferably in solid or semi-solid form. Of course, solids are fundamental, and are generally referred to as states of matter (others being liquids, gases and plasmas). Semisolid is the physical term for something whose state is between a solid and a liquid. Semi-solid materials are similar to solids in some characteristics, such as their ability to support their own weight and maintain their shape. Examples of semi-solids are peanut butter, toothpaste and petrolatum. The formulation of compounds and ingredients for formulation in, on, or within an onsert, precision rod or precision pod may include solids, semi-solids and liquids, although the final formulated formulation is preferably a solid or semi-solid (e-liquid). not a liquid such as ). For example, a blend of ingredients within a compartment of a precision pod may include crystalline nicotine salt, concentrated hemp wax, and liquid glycerin, so that the final blended formulation, even if liquid has been used (adding an appropriate level of moisture, to be solid or semi-solid (depending on the proportions of each of the three components used).

A nicotine salt is a form of nicotine characterized by the interaction between nicotine in ionic form and a coformer in ionic form, such as an acid, by transferring one or more protons from a coformer donor to a nicotine acceptor. Since the structure of nicotine has two nitrogen atoms that can accept protons from the co-former, it can exist in un-protonated, mono-protonated or di-protonated forms. Examples of nicotine salts include, but are not limited to: nicotine 4-acetamidobenzoate, nicotine ascorbate, nicotine aspartate, nicotine benzoate, nicotine bitartrate, nicotine chlorides such as nicotine dihydrochloride and nicotine hydrochloride. , nicotine citrate, nicotine 2,3-dihydroxybenzoate, nicotine 3,5-dihydroxybenzoate, nicotine fumarate, nicotine gentisate (2,5-hydroxybenzoic acid), nicotine glutamate, nicotine l -Hydroxy-2-naphthoate, nicotine 3-hydroxybenzoate, nicotine lactic acid, nicotine levulin, nicotine malate, nicotine mono-pyruvate, nicotine mucate, nicotine perchlorate, nicotine pyruvate, nicotine salicyl Late, nicotine succinate, nicotine sulfate, nicotine tartrate and nicotine zinc chloride.

A nicotine co-crystal is a form of nicotine comprising nicotine and at least one other component (co-former), both in neutral form. Co-crystals are usually characterized by a crystalline structure, which is usually held together by freely reversible non-covalent interactions. A co-crystal usually consists of nicotine and at least one other component in defined stoichiometric proportions, and may include hydrates, solvates and clathrates. A co-crystal may contain nicotine in combination with an organic and/or inorganic component and is generally distinguished from a salt in that there is no proton transfer between the components (nicotine and one or more co-formers) in the co-crystal. In contrast, nicotine salt co-crystals are a type of hybrid structure having both salt and co-crystal features. Generally, a nicotine molecule in a salt co-crystal is associated with at least two co-formers (which may be the same or different), wherein one co-former is in an ionic form, such as an acid, and transfers a proton to the nicotine molecule, and a second co-former does not transfer a proton to the nicotine molecule. Any form of nicotine, including nicotine salts, nicotine co-crystals, and/or nicotine salt co-crystals, may be used herein for any onsert, precision rod or precision pod embodiment.

As used herein, "cigarette" means any roll of tobacco that may include non-tobacco material, is wrapped in paper, and which burns when lit to produce smoke. Cigarettes also generally include filters, plug wraps (which contain the filtration material) and tipping paper (which holds the cigarette paper to the filter and plug wraps). Glue seals the cigarette paper to each other, and if the cigarette has a filter, the glue holds these other components together. The term cigarette also includes any roll of tobacco wrapped in any material containing tobacco, which, because of its appearance, the type of tobacco used, or its packaging and labeling, is offered to or purchased by the consumer as a cigarette. is likely to be One example is a 'little cigar' which may include a filter and generally looks very similar to a cigarette. Factory manufactured tobacco means tobacco manufactured and rolled up in a factory by a tobacco manufacturer, and unless provided to smokers as research tobacco, factory manufactured tobacco is generally purchased from retail outlets by the end user. Factory-made cigarettes are usually supplied in packs of 20 cigarettes. As used herein, "marijuana cigarette" means any roll of hemp or any other non-tobacco material wrapped in paper, and when lit, produces smoke for inhalation. Marijuana cigarettes (ie, joints) do not contain tobacco; As disclosed herein, when an onsert or precision rod is attached to or inserted into a marijuana cigarette, it can produce nicotine or other tobacco alkaloids. Marijuana cigarettes may be rolled by hemp end users or manufactured in factories by hemp manufacturers. Unlike marijuana cigarettes, a blunt is a marijuana that is rolled up in a tobacco leaf or cigar wrapper that contains tobacco, and a spliff is a marijuana cigarette that also contains tobacco.

Unlike factory-made cigarettes, roll-your-own (RYO) cigarettes or make-your-own (MIO) cigarettes are made by the tobacco end user. RYO cigarettes are made from tobacco and rolling paper. You can also use a tobacco roller to roll the tobacco into rolling paper. MYO cigarettes are generally made with mechanical MYO machines that insert cigarettes and tobacco into empty cigarette tubes (with or without filters). The mechanism inserts a cigarette into a tube, resulting in a cigarette that looks very much like a factory-roll cigarette bought in a regular store. While RYO (Tobacco and Rolling Paper) or MYO (Tobacco and Tube) cigarettes are generally cheaper to purchase by consumers than factory-made cigarettes respectively, RYO and MYO cigarettes are time-consuming, tedious, and usually factory-made It does not have the uniformity or quality of cigarettes. RYO cigarettes and MYO cigarettes are essentially the same and are very similar to the fillers of factory-made cigarettes. RYO Tobacco, MYO Tobacco, and Pipe Tobacco are all end tobacco products (as defined below) that tobacco end users purchase for smoking.

As used herein, a "filler" is a rod of a cigarette, or a tobacco stick of a tobacco heating device (or wrapped in a tobacco heating rod [eg, TEEPS®] if the tobacco heating product does not have a separate holder), selected from the group consisting of chopped tobacco leaves (cut-rag), tobacco stems, reconstituted tobacco, puffed tobacco, hemp, casing, flavoring and other additives or ingredients such as cannabinoids or additional alkaloids (other than cigarette paper) ) means cumulative smokeable substances. Reconstituted cigarettes are generally included in the fillers of factory-made cigarettes and are similar to cut rag cigarettes. Expanded cigarettes are also commonly included in fillers of factory-made cigarettes and are treated through inflation of a suitable gas to reduce the density of the tobacco rod and increase its filling capacity as the tobacco is 'puffed'. The puffed tobacco reduces the weight of the tobacco used in the cigarette.

As used herein, "reconstituted tobacco", also known as Recon, means a sheet of tobacco produced by rolling or casting pre-finely ground tobacco powder, stems and/or by-products followed by mixing with a coagulant or binder; , usually contain wetting agents, flavoring agents, and preservatives. This results in a paper-like malleable sheet that is essentially reconstituted tobacco. Two types of reconstituted cigarettes known in the art are band cast and paper cast. For each of these, every producer has a slightly different process. The Recon process makes it possible to add virtually any compound or plant fraction. Once the reconstituted tobacco sheet is made, cut it into small strips. The size and shape of the strips are generally similar to the size of cut-rag cigarettes, although reconstituted tobacco can be compounded into the filler of a cigarette; Large Recon sheets can be cut to any size. See, eg, US Pat. Nos. 4,270,552 and 5,724,998 and Chapter 11, 377-379, Tobacco: Production, Chemistry and Technology, 1999. Nicotine, anatabine, anabacin, THCA, CBDA, CBCA, CBGA, THCVA, CBDVA, CBCVA, CBGVA, myrcene, caryophyllene, pinene, limonene and/or humulene are added during the Recon production process before the sheet is made. can be integrated. In some exemplary embodiments herein, the reconstituted tobacco sheet is used to make a wrapper for onsert, the reconstituted sheet can be cut accordingly, or the reconstituted tobacco sheet can be very finely cut and ground to be incorporated into precision pods or precision rods. there is. In another exemplary embodiment, an ultra-low nicotine cigarette is reconstituted and used for an onsert, precision rod or precision pod.

As used herein, "reconstituted hemp" refers to hemp flowers, leaves, flour, stems and/or previously finely ground by-products that are then rolled or cast and generally contain a flocculating agent or means a hemp sheet produced in the same manner as a reconstituted tobacco sheet mixed with a binder. Since reconstituted hemp sheets need not contain any tobacco fraction, they can be made tobacco-free, nicotine-free if nicotine is not required, and can be easily made into reconstituted sheets similar to reconstituted tobacco. The hemp portion of the reconstituted hemp sheet may be made from about 70% to about 90% hemp plant parts. Once made, the reconstituted hemp sheet is cut to any size desired. In some exemplary embodiments, reconstituted hemp is used in the manufacture of wrappers for onserts or is very finely cut and incorporated into precision pods or precision rods. Nicotine, Anatabine, Anavacine, THCA, CBDA, CBCA, CBGA, THCVA, CBDVA, CBCVA, CBGVA, Myrcene, Caryophyllene, Pinene, Limonene and/or Humulene are produced during the reconstituted production process before the reconstituted hemp sheet is made. It can be further integrated. Ultra-low THC hemp or THC-free hemp can be produced from a hemp line or strain that has been genetically engineered for ultra-low THC content and used for reconstituted hemp, or a strain or strain of hemp. Both ultra-low THC hemp and low nicotine (or zero nicotine) cigarettes can be used in the same reconstituted sheet.

In another exemplary embodiment, reconstituted plant material (eg, leaves and stems) is utilized for use in precision pods or precision rods or in the production of wrappers for onserts, and the reconstituted sheet does not contain any tobacco or hemp. For example, herbs such as jasmine and ginseng are used in the production of “reconstituted herbal sheets”. Whether reconstituted tobacco, reconstituted hemp and/or reconstituted jasmine, for example, nicotine, anatabine, anabacin, THCA, CBDA, CBCA, CBGA, THCVA, CBDVA, CBCVA, CBGVA, myrcene, caryophyllene, pinene, limonene and/or humulene is incorporated (infused) during the Recon production process before the reconstituted sheet is manufactured.

As used herein, "end tobacco product" means a tobacco product prepared for consumer use or consumption, and includes cigarettes, cigars, cigarillos, cigarillos, and RYO cigarettes (where the end user Or used as a roll of paper to roll marijuana cigarettes) Do-it-yourself (MYO) cigarettes (usually used by end users, to make their own cigarettes or marijuana cigarettes, in conjunction with cigarette tubes and mechanical MYO machines, tobacco or hemp is inserted into an empty cigarette tube by the machine), hemp, pipe tobacco, tobacco heating products (eg, IQOS®), snuff, snus, and chewing tobacco such as dipping tobacco. However, the present invention is not limited thereto. E-cigarettes are not tobacco products because the only fraction of the tobacco they contain is nicotine. RYO cigarettes or MYO cigarettes may not be designated as either on the packaging, and may be referred to as “cigarettes” because they may be used as RYO cigarettes or MYO cigarettes.

As used herein, a "smoking product" is when ignited, inhaled when used by itself (eg, a cigarette) or when used with an interdependent smoking product (eg, pipe and pipe tobacco are interdependent). Any cigarette prepared for consumer use or consumption that produces mainstream smoke for Product means Cigarette, Cigarette, RYO Tobacco, Hemp, RYO Tobacco or Hemp Rolling Paper, Homemade Tobacco, MYO Tobacco or Hemp Tube, Pipe, Bowl, Rod, Tobacco , reconstituted tobacco, split, blunt, and marijuana cigarettes. Individually or collectively, RYO cigarettes and MYO cigarettes may be referred to herein as 'tobacco' or 'finished tobacco'. A bowl is a type of pipe that usually has a shorter stem. A 'tobacco chamber', 'hemp chamber' or 'chamber' is where tobacco or hemp is burned in pipes, bowls and rods. Onserts, precision rods, and certain precision pods (not for carburetors) are also smoking products.

As used herein, "conventional cigarette" means a cigarette having a conventional nicotine content of at least 9 mg per cigarette. The average nicotine content of conventional commercial cigarette brands is approximately 14 mg of nicotine per cigarette, but may range from approximately 9 mg to greater than 20 mg of nicotine per cigarette. Morton et al. 2008, Regul Toxicol Pharmacol . see doi: 10.1016/j.yrtph.2008.03.001.

As used herein, an "ultra-low nicotine cigarette" is a cigarette containing no more than 2.0 milligrams (mg) of nicotine, such as 0.05 mg, 0.10 mg, 0.15 mg, 0.20 mg, 0.25 mg, 0.30 mg, 0.35 mg per cigarette. , 0.40 mg, 0.45 mg, 0.50 mg, 0.55 mg, 0.60 mg, 0.65 mg, 0.70 mg, 0.75 mg, 0.80 mg, 0.85 mg, 0.90 mg, 0.95 mg, 1.00 mg, 1.05 mg, 1.10 mg, 1.15 mg, 1.20 Contains less than mg, 1.25 mg, 1.30 mg, 1.35 mg, 1.40 mg, 1.45 mg, 1.50 mg, 1.55 mg, 1.60 mg, 1.65 mg, 1.70 mg, 1.75 mg, 1.80 mg 1.85 mg, 1.90 mg, or 1.95 mg of nicotine means cigarettes. The nicotine content per cigarette is calculated by multiplying the weight of the filler in the cigarette rod by the nicotine content of the filler in the cigarette rod. For example, if the weight of the cigarette filler is 0.666 grams and the nicotine content is 3 mg/g, the nicotine content of the cigarette is about 2 mg. A filler having a nicotine content of 3 mg/g corresponds to approximately 85% of the average nicotine content of a tobacco filler of an existing cigarette brand of about 20 mg/g.

Ultra-low nicotine cigarettes have been manufactured by the tobacco industry at various times over several decades. The John Alden Tobacco Company, for example, manufactured John Alden 's ultra-low nicotine cigarette brand in the 1950s, and said, "At least 85% less nicotine than the two leading filter tip brands. tip brands),” the brand advertised. The low nicotine cigarettes used in John Alden 's ultra low nicotine cigarettes have been classified as Type 31-V by the US Department of Agriculture. In addition to growing tobacco that already has very low nicotine, other processes have been developed. For example, Philip Morris USA has developed a commercial supercritical CO2 process that removes 97% of the nicotine from the filler and marketed several brands of ultra-low nicotine cigarettes.

As used herein, a "nicotine-fortified cigarette" is an industry-accepted standardized smoking machine test method (e.g., For example, the nicotine smoke yield of a cigarette is at least 7% as measured by the International Organization for Standardization [ISO] Smoking-Machine Test Method 4387:2000 [Cigarette - Determination of Total and Nicotine Free Dry Particulate Matter Using a Conventional Analytical Smoking Machine]) means a cigarette containing an auxiliary nicotine source (eg, from an onsert or precision pod) that results in an increase. The nicotine yield of ultra-low nicotine cigarettes or conventional cigarettes can be improved by supplemental nicotine sources. Other examples of industry accepted and standardized smoking machine testing methods are the Canadian intense method, the Massachusetts method, and the Federal Trade Commission (FTC) method. In addition to supplemental nicotine sources, nicotine fortified cigarettes may also utilize devices for use with supplemental nicotine sources, such as cigarette holders.

Depending on the design of the cigarette into which the supplemental nicotine source is infused, including the cigarette's ventilation level, an increase in nicotine smoke yield will increase for a given amount of supplemental nicotine (e.g., a precision rod comprising 10 mg of nicotine) by cigarette type. Each will be different. Just as small amounts of nicotine in cigarette fillers (which cigarettes have an average nicotine content of about 14 mg) are delivered to mainstream smoke (which can be measured by smokers), this is virtually the same at about 1% nicotine content in highly ventilated cigarettes. Non-ventilated cigarettes reach up to about 10% nicotine, and similarly small amounts of nicotine are transferred into mainstream smoke from onsert or precision rods. This nicotine delivery rate, which is the rate at which the nicotine content in a cigarette filler (and/or the nicotine content in a nicotine onsert) is delivered into mainstream smoke as measured by a smoking machine, also includes cigarette paper and/or an auxiliary nicotine source (e.g. For example, onsert) depends on whether (or at what level) combustion accelerators or re-conditioners are included. The manner in which a smoking product, including a cigarette, is smoked (ie, smokes strongly, loudly and frequently, or not) also affects the rate of nicotine delivery of the cigarette, with or without an auxiliary nicotine source. Certain smoking regimes, such as the ISO, Canadian intense method, or Massachusetts method, standardize nicotine yield with and without onsert or precision load, respectively.

The increased nicotine yield of the smoke of the nicotine fortified cigarette can be, for example, at least 0.002 mg, 0.003 mg, 0.004 mg, 0.005 mg, 0.006 mg, 0.007 mg, 0.008 mg, 0.009 mg, 0.010 mg, 0.011 mg, 0.012 mg, 0.013 mg, 0.014 mg, 0.015 mg, 0.016 mg, 0.017 mg, 0.018 mg, 0.019 mg, 0.020 mg, 0.025 mg, 0.030 mg, 0.035 mg, 0.040 mg, 0.045 mg, 0.050 mg, 0.055 mg, 0.060 mg, 0.065 mg, 0.070 mg, 0.075 mg, 0.080 mg, 0.085 mg, 0.090 mg, 0.095 mg, 0.100 mg, 0.125 mg, 0.150 mg, 0.175 mg, 0.200 mg, 0.225 mg, 0.250 mg, 0.275 mg, 0.300 mg , 0.325 mg, 0.350 mg, 0.375 mg, 0.400 mg, 0.425 mg, 0.450 mg, 0.475 mg, 0.500 mg, 0.525 mg, 0.550 mg, 0.575 mg, 0.600 mg, 0.625 mg, 0.650 mg, 0.675 mg, 0.700 mg, 0.725 mg, 0.750 mg, 0.775 mg, 0.800 mg, 0.825 mg, 0.850 mg, 0.875 mg, 0.900 mg, 0.925 mg, 0.950 mg, 0.975 mg or 1.000 mg nicotine, etc. For example, a nicotine fortified cigarette may be an ultra-low nicotine cigarette with an increased nicotine yield from 0.03 mg to 0.05 mg.

As used herein, "anatabine-fortified cigarette" means a cigarette comprising an adjuvant anatabine source, thus as measured by a test method capable of quantifying anatabine in smoke, and said adjuvant anatabine Produces a cigarette having an increased anatabine yield of at least 7% as measured by the same test method as compared to a factory manufactured cigarette of the same type without a tabine source. For an example of such a test method, see Zhang et al., 2018, Rapid Commun Mass Spectrom ., 32:1791-1798 (DOI: 10.1002/rcm.8222). The anatabine yield of ultra-low nicotine cigarettes or conventional cigarettes can be improved, for example, by supplemental anatabine sources from onsert or precision rods.

Such anatabine source may be a plant comprising tobacco plants rich in anatabine, wherein the anatabine is extracted by, for example, a supercritical CO ₂ extraction process. The anatabine content may also be enhanced by anatabine salts of organic acids, ananatabine analogues or synthetic anatabine. The increased anatabine yield of smoke of an anatabine fortified cigarette can be, for example, at least 0.10 μg, 0.15 μg, 0.20 μg, 0.25 μg, 0.30 μg, 0.35 μg, 0.40 μg, 0.45 μg, 0.50 μg , 0.55 μg, 0.60 μg, 0.65 μg, 0.70 μg, 0.75 μg, 0.80 μg, 0.85 μg, 0.90 μg, 0.95 μg, 1.00 μg, 1.10 μg, 1.20 μg, 1.30 μg, 1.40 μg, 1.50 μg, 1.60 μg, 1.70 μg, 1.80 μg, 1.90 μg, 2.0 μg, 2.25 μg, 2.50 μg, 2.75 μg, 3.0 μg, 3.25 μg, 3.50 μg, 3.75 μg, 4.0 μg, 4.25 μg, 4.50 μg, 4.75 μg, 5.0 μg, 5.25 μg, 5.50 μg, 5.75 μg, 6.0 μg, 6.25 μg, 6.50 μg, 6.75 μg, 7.0 μg, 7.25 μg, 7.50 μg, 7.75 μg, 8.0 μg, 8.25 μg, 8.50 μg, 8.75 μg, 9.0 μg, 9.25 μg, 9.50 μg , 9.75 μg, 10 μg, 11 μg, 12 μg, 13 μg, 14 μg, 15 μg, 16 μg, 17 μg, 18 μg, 19 μg, 20 μg, 21 μg, 22 μg, 23 μg, 24 μg, 25 Equivalent to anatabine per μg, 30 μg, 35 μg, 40 μg, 45 μg or 50 μg cigarette. An advantage of anatabine-fortified ultra-low nicotine cigarettes is that these types of cigarettes reduce withdrawal and cravings from conventional cigarettes more effectively than ultra-low nicotine cigarettes without fortified anatabine. Anatabine-fortified ultra-low nicotine cigarettes are particularly useful when used to help smokers switch to e-cigarettes or cigarette heating devices, or to help smokers quit tobacco and nicotine use completely.

As used herein, "anavacin fortified cigarette" means a cigarette comprising a supplemental anabacin source, and thus anabacin in smoke, as measured by a quantifiable test method, and said supplemental anabacin Produces a cigarette having an increased anabacin yield of at least 7% as measured by the same test method as compared to a factory manufactured cigarette of the same type without the sauce. For an example of such a test method, see Zhang et al., 2018, Rapid Commun Mass Spectrom ., 32:1791-1798 (DOI: 10.1002/rcm.8222). The anabacin yield of ultra-low nicotine cigarettes or conventional cigarettes can be improved, for example, by an auxiliary anabacin source from an onsert or precision rod.

Such anabacin sources are tobacco plants or plants in which the predominant alkaloid is anabacin, such as Nicotiana glauca , Nicotiana noctiflora , Nicotiana petunioides and/or Nicotiana dev. It may be a Nicotiana debneyi plant. Anavacin can be extracted from any type of tobacco, for example, by a supercritical CO2 extraction process. The anabacin content may also be enhanced by anabacin salts of organic acids, anabacin analogues or synthesized anabacin. The increased anabacin yield of the anabacin fortified cigarette can be, for example, at least: 0.01 μg, 0.02 μg, 0.03 μg, 0.04 μg, 0.05 μg, 0.06 μg, 0.07 μg, 0.08 μg, 0.09 μg, 0.10 μg, 0.15 μg, 0.20 μg, 0.25 μg, 0.30 μg, 0.35 μg, 0.40 μg, 0.45 μg, 0.50 μg, 0.55 μg, 0.60 μg, 0.65 μg, 0.70 μg, 0.75 μg, 0.80 μg, 0.85 μg, 0.90 μg , 0.95 μg, 1.00 μg, 1.10 μg, 1.20 μg, 1.30 μg, 1.40 μg, 1.50 μg, 1.60 μg, 1.70 μg, 1.80 μg, 1.90 μg, 2.0 μg, 2.25 μg, 2.50 μg, 2.75 μg, 3.0 μg, 3.25 μg, 3.50 μg, 3.75 μg, 4.0 μg, 4.25 μg, 4.50 μg, 4.75 μg, 5.0 μg, 5.25 μg, 5.50 μg, 5.75 μg, 6.0 μg, 6.25 μg, 6.50 μg, 6.75 μg, 7.0 μg, 7.25 μg, 7.50 μg, 7.75 μg, 8.0 μg, 8.25 μg, 8.50 μg, 8.75 μg, 9.0 μg, 9.25 μg, 9.50 μg, 9.75 μg, 10 μg, 11 μg, 12 μg, 13 μg, 14 μg, 15 μg, 16 μg , 17 μg, 18 μg, 19 μg, 20 μg, 21 μg, 22 μg, 23 μg, 24 μg, 25 μg, 26 μg, 27 μg, 28 μg, 29 μg, or 30 μg of anabacin per cigarette. . An advantage of anabacin fortified ultra low nicotine cigarettes is that these types of cigarettes reduce withdrawal and cravings from conventional cigarettes more effectively than ultra low nicotine cigarettes without fortified anabacin. Anabacin-fortified ultra-low nicotine cigarettes are particularly useful when used to help smokers switch to e-cigarettes or cigarette heating devices, or to help smokers quit tobacco and nicotine use completely.

Total alkaloid levels or individual alkaloid levels in tobacco or fillers, such as levels of nicotine, anatabine or anabacin, can be measured by a number of methods known in the art. Examples include quantification based on gas chromatography (GC) and high performance liquid chromatography. See, for example, Lisko et al., 2013, Anal Chem . March 19; See 85(6): 3380-3384, which provides the following methods for determining the amount of alkaloids in fillers by cigarette brand and alkaloids in tobacco types (eg Burleys). Analysis of small amounts of alkaloids, such as anatabine or anabacin, uses gas chromatography (GC) combined with a wide range of detection techniques including flame ionization detection (FID), nitrogen-phosphorus detection (NPD), and mass spectrometry (MS). has been carried out Other analytical approaches include high-performance liquid chromatography-ultraviolet detection (HPLC-UV), capillary zone electrophoresis-ultraviolet detection (CZE-UV), micellar electrodynamic capillary chromatography-ultraviolet detection (MECC-UV), nitrogen chemiluminescence detection ( NCD), and microemulsion electrodynamic chromatography-ultraviolet detection (MEEKC-UV). Gas chromatography-tandem mass spectrometry (GC-MS/MS) in multiple reaction mode (MRM) mode removes matrix ions from other compounds that share the same parent mass but lack the correct transition ions, By dramatically reducing background interference and reducing detection limits, greater compound specificity can be allowed. The amount of nicotine (and propylene glycol and glycerol) in the formulation in the e-liquid or precision rod or precision pod can be determined by ISO/DIS 20714, which is a gas chromatography method, or any other method known in the art. . Unless otherwise specified or implied, analyte measurements (eg, nicotine) are made on a dry weight basis.

For any of the exemplary embodiments herein, nicotine is a high nicotine N Rustica ( N. rustica ) plant, such as a Nicotiana ( Nicotiana ) plant for extracting nicotine, anatabine and anabacin, followed by purifying the extract. It is first provided by any one of a variety of methods known in These methods are utilized in nicotine replacement therapy products such as nicotine candies and nicotine patches. Alternatively, in another embodiment, synthetic nicotine, synthetic anatabine, or synthetic anabacin is provided first, which provides the advantage of not being extracted from tobacco. See, eg, US Pat. No. 9,556,142 and 2005 The AAPS Journal to Ayers et al.; See 7(3) Article 75, E752-E758 (http://www.aapsj.org). The nicotine is then prepared, preferably in solid or semi-solid form, by any of the methods known in the art. They may be in crystalline and/or amorphous form.

Upon crystallization or solidification, the nicotine salt may be cut or milled to form any shape or size depending on the application. For nicotine powder applications, the size may be as small as 25 μm, and for other applications, the size may be 5 mm. Alternatively, nicotine salts are commercially available. For example, nicotine bitartrate dehydrate, in powder form, a pure water-soluble crystalline salt of nicotine used in the production of nicotine candies and gums is available from Alchem International SA.

ELECTRONIC NICOTINE DELIVERY SYSTEMS (ENDS)

Many types of ENDS have been developed and marketed over the past decade. For example, a cigarette heating product consists of a holder, a cigarette stick and a filling machine. For example, an IQOS® cigarette stick (HeatStick®) is inserted into an IQOS® holder that heats the tobacco material by means of an electronically controlled heating blade. HeatStick® differs from cigarettes in several ways. For example, the cigarettes in HeatSticks® for IQOS® products are made from non-burning tobacco powder, which is uniquely engineered and specially designed to function with a holder to create an aerosol. In another exemplary configuration, the cigarette heating device is ignited like a conventional cigarette. There may be no holder, charger or battery, and the cigarette may be heated directly in the cigarette heating rod. For example, an ignited carbon heat source heats (but does not burn) a cigarette, producing an aerosol similar to a cigarette heating device comprising separate tobacco sticks. A type of cigarette heating device with a carbon heat source is physically very similar to, for example, a conventional cigarette, but does not burn. A disposable heating element is contained within each rod that generates an aerosol that is inhaled and is known herein as a “cigarette heating rod” or “heating rod”. One example is TEEPS® being developed by Philip Morris International. Other examples include Eclipse® and Revo®, which were previously sold in the United States but are no longer sold. In another configuration, the cigarette heating device does not have a holder or charger, and includes a battery in every heating rod, each heating rod being disposable. Thus, it is understood that any device that generates an aerosol (without burning tobacco) by heating a tobacco (or tobacco in a form such as tobacco extract or reconstituted tobacco) to a temperature lower than combustion is a tobacco heating device, including a holder or It doesn't matter whether there is a separate cigarette stick from the heating element, whether or not a battery charge or even a battery is required, whether any parts need to be ignited, such as the end of a carbon heat source, and/or whether any electronics are included. does not As used herein, the terms tobacco heating device, tobacco heating product, non-burn-heated tobacco device, and non-burn-heated tobacco product are synonymous.

E-cigarettes are rechargeable devices that include a heating coil and an atomizer that converts e-liquid into an aerosol (also called e-juice), a cartridge containing e-liquid, etc. (stick or pod), a mouthpiece , and batteries for rechargeable devices. There are many appearances and designs that can include various steps, but they generally work by inhaling the e-cigarette, activating a heating element that aerosolizes the e-liquid, and inhaling the aerosol. The e-liquid usually contains nicotine, water, flavoring and wetting agents. Wetting agents act as carrier solvents that dissolve and aerosolize nicotine and flavoring agents at specific temperatures on the atomizer of the e-cigarette. Typically, propylene glycol and/or glycerol are solvents used for e-liquids. For example, the e-liquid of an e-cigarette contained in a cartridge has a nicotine content that varies greatly by brand and brand style.

Vaporizers (vapes) vaporize plant material, typically hemp, in order to inhale the material without burning it. These include both dry herbal vaporizers (eg, for hemp flowers) and vaporizers configured for plant extracts such as concentrates or wax extracts. Some vaporizers are configured for both dried herbs and concentrated extracts such as PAX 3®. Vaporizers configured for dry herbs and/or concentrates are typically open systems, allowing the user to place whatever they wish into the oven chamber and then the oven chamber closed with a cover or the like. This type of open system vaporizer, such as the PAX 2®, uses a tobacco stick and is distinct from closed system vaporizers such as glo® and IQOS®, which do not have access to cigarettes; Open system vaporizers work similarly to glo® and IQOS®, in that open systems also likewise generate vapor from smokeable plant material (eg, hemp), which typically has a moisture level of about 10% to about 17%. because it makes The ready-to-vape precision pods disclosed herein can work with dry herb vaporizers and vaporizers for beneficial concentrates. Also, open system vaporizers are distinct from e-cigarettes in that the e-cigarettes use e-liquid and open system vaporizers do not. In comparison to the exemplary embodiment herein of a ready-to-vape precision pod comprising nicotine in a concentrated form, the e-cigarette contains approximately 0.7 ml or less of the nicotine in the e-liquid, generally equal to 5% nicotine by weight. Because it is dramatically diluted in concentration, it forces the user to inhale a much larger amount of vapor for a satisfactory amount of nicotine (eg, 1 mg). Some other vaping devices provide e-liquids at higher concentrations, but none come close to the concentration of nicotine in a formulation of ready-to-vape tobacco precision pods, including, for example, crystalline cannabinoids and crystalline nicotine salts.

The vaporizer includes a thermostat, an oven or vaporization chamber (where the material to be heated is placed), a cover for the oven chamber, a mouthpiece, an electronic heater with a sensor and a rechargeable battery. In general, compared to burning hemp from smoking products, extraction of cannabinoids occurs significantly more in vaporizers that heat hemp due to lack of combustion. Typical temperatures for vaporizers in oven chambers range from about 160°C to about 230°C, producing vapors for inhalation; The range may be wider (eg 100°C to 265°C) as higher temperatures are required for the concentrate. Mainstream vapors are vapors that are inhaled, and include vapors from a person's mouth using a vaporizer or from the mouth end of a vaporizer.

Hemp and Hemp Formulations

As used herein, "Cannabis" includes Cannabis sativa, Cannabis indica and Cannabis ruderalis . Both marijuana and hemp strains or cultivars are cannabis. Hemp is more genetically similar to the indica type of marijuana than the sativa strain. Cannabinoids are a group of over 100 natural chemical compounds that accumulate primarily in the female flowers (also known as buds) of the hemp plant. They act on intracellular cannabis receptors that alter the release of neurotransmitters in the brain. THCA/THC is one of dozens of cannabinoids present in the cannabis plant. Cannabinoids can be endogenously produced by tobacco plants genetically engineered for use with onserts, precision rods and precision pods, produced synthetically (see, e.g., U.S. Pat. No. 9,587,212), or extracted from cannabis plants. there is. When a smoker quits a conventional cigarette, the level of anxiety and depression generally increases; Thus, ultra-low nicotine cigarettes combined with on-sert or precision rods containing very trace amounts of crystalline CBDA are beneficial in helping smokers switch to e-cigarettes or tobacco heating devices or quit tobacco and nicotine use entirely. For these applications, smoke from ultra-low nicotine cigarettes that also contain non-THC cannabinoids in onsert or precision rods is improved compared to smoke from ultra-low nicotine cigarettes without cannabinoids. As disclosed in U.S. Patent Application No. 16/047,948, the longer a smoker can exclusively smoke an ultra-low nicotine cigarette (without smoking any conventional cigarettes) during the transition period, the longer he or she switches to an e-cigarette or a tobacco heating product, or You are more likely to quit smoking and nicotine use completely.

The psychoactive effects of THC are mainly mediated by the activation of cannabinoid receptors distributed throughout the body, which are part of the endocannabinoid system involved in various physiological processes such as mood and appetite. The use of hemp strains (containing significant THCA content) or marijuana strains or cultivars is problematic for inclusion in ultra-low nicotine cigarettes to help smokers switch to e-cigarettes or cigarette heating devices, as the psychoactive effects of THC may be compromised. This is because it will interfere with their daily life in that it will diminish the physical and mental control of smokers. For example, a smoker attempting to switch to an e-cigarette or cigarette heating device will not be able to smoke ultra-low nicotine cigarettes containing significant levels of THCA during lunch breaks while working, and thus not function normally when returning to work. may not be, and this may be a danger to colleagues. In addition, if an ultra-low nicotine cigarette contains hemp containing THCA, the employee may fail the drug test. Thus, inclusion of crystalline CBDA (and not hemp) from onsert or precision rods with ultra-low nicotine cigarettes or conventional cigarettes, or from precision pods with vaporizers to prevent any psychoactive effects of THC while maintaining the benefits of CBD It is useful and advantageous to Crystalline CBDA, which is 99.5% pure, does not have any intoxicating effects of THC.

9-테트라하이드로카나비놀산), CBDA(카나비디올산), CBCA(카나비크로멘산), CBGVA(카나비게로바린산), THCVA(테트라하이드로카나비바린산), CBDVA(카나비디바린산) 및 CBCVA(카나비크로메바린산)의 각각은 하기 8가지 카나비노이드 화합물로 변환되어, 이를 수득할 수 있게 한다: CBG(카나비게롤), THC(

9-테트라하이드로카나비놀), CBD(카나비디올), CBC(카나비크로멘), CBGV(카나비게리바린), THCV(테트라하이드로카나비바린), CBDV(카나비디바린) 및 CBCV(카나비크로메바린). 대마가 경화되어 수분이 감소함에 따라, 산성 형태의 카나비노이드 화합물이 성숙하여 관련 화합물로 (예를 들어, THCA에서 THC로) 서서히 변환된다. 대마를 경화시키고 시간이 지남에 따라 보관하면 부분적인 탈카르복실화만이 발생하는데, 대마 꽃이 검사에서, 예를 들어 THCA 및 THC (본원에서 THCA/THC로 표시됨) 둘 다에 대해 대부분 양성인 이유가 이 때문이다. 대마를 흡연하거나 기화시키면, 고온의 존재로 인해 카나비노이드를 산성 형태(예: THCA에서 THC로)로 탈카르복실화하여, 이를 흡입을 통해 즉시 흡수될 수 있게 한다.To understand the cannabinoid biosynthetic pathway in Cannabis sativa . Cannabigerolic acid (CBGA) is a precursor to three major cannabinoid families: tetrahydrocannabinolic acid (THCA), cannabidioic acid (CBDA) and cannabichromenic acid (CBCA). During the decarboxylation that occurs during drying and drying of plant material and/or when the cannabinoid acids are heated (eg, when smoking), the following eight cannabinoid acids are: CBGA (cannabigerolic acid), THCA (

9-tetrahydrocannabinolic acid), CBDA (cannabidiolic acid), CBCA (cannabichromenic acid), CBGVA (cannabigerovaric acid), THCVA (tetrahydrocannabivaric acid), CBDVA (cannabidivaric acid), and CBCVA Each of (cannabichromevaric acid) is converted into the following eight cannabinoid compounds, making it possible to obtain them: CBG (cannabigerol), THC (

9-tetrahydrocannabinol), CBD (cannabidiol), CBC (cannabichromen), CBGV (cannabigerivarin), THCV (tetrahydrocannabinol), CBDV (cannabidivarin) and CBCV (Cannabichromevarin). As hemp hardens and loses moisture, the acidic form of the cannabinoid compounds mature and are slowly converted into related compounds (eg, THCA to THC). When hemp is cured and stored over time, only partial decarboxylation occurs, which is why hemp flowers are mostly positive in tests, for example, for both THCA and THC (referred to herein as THCA/THC). For this reason. When cannabis is smoked or vaporized, the presence of high temperatures decarboxylates the cannabinoids to acidic forms (eg, THCA to THC), which can be absorbed immediately by inhalation.

The cannabinoid acid content of the exemplary embodiments of the onsert, precision rod or precision pod herein, such as CBDA, includes the corresponding cannabinoid, as partial decarboxylation may have occurred in the cannabinoid acid, such as CBDA to CBD. Items quantified as containing 24 mg CBDA and 1 mg CBD during analytical testing of cannabinoid acids and cannabinoids, for example, onserts, precision rods, precision pods, cannabis plants, cannabis strains and cannabis varieties. is equivalent to the item described herein as 25 mg CBDA. Thus, due to the potential partial decarboxylation of cannabinoid acids to cannabinoids, cannabinoid acids and cannabinoids can sometimes be used interchangeably, in which case they can be expressed as 25 mg CBDA, 25 mg CBD or 25 mg CBDA/CBD. and all of which are understood herein to have equivalent meanings.

Every strain or variety of hemp has a unique cannabinoid profile, and the content of each cannabinoid in a batch or formulation of hemp divided by the total content of all cannabinoids, which is measured as the ratio or percentage of one or more cannabinoids to one or more other cannabinoids . An example of a cannabinoid profile in a 10 pound batch of hemp is that the THCA/THC content is 65% of the total content of all cannabinoids, with the remaining cannabinoids comprising the remaining 35%. Non-THCA/THC cannabinoids can be further characterized. The ratio of THCA to CBDA is also an example of a cannabinoid profile. Multiple samples may be taken from a batch or plant, combined for testing purposes, and two or more replicates may be made. Regardless of the hemp strain or cultivar, CBDA/CBD and THCA/THC are generally the two most common cannabinoids in hemp. There is generally an inverse relationship between THCA and CBDA across hemp strains and varieties. The higher the THCA/THC content, the lower the CBDA/CBD content, and the higher the CBDA/CBD content, the lower the THCA/THC content. CBDA/CBD is generally the most abundant cannabinoid combination in a hemp strain or variety. THCA/THC is the most abundant cannabinoid combination in the marijuana strain, and can typically be approximately 10-20% by weight of the hemp flower. This CBDA-CBD/THCA-THC relationship between hemp and marijuana contains more CBDA/CBD as hemp has been bred for seed and biomass for centuries, but marijuana has been bred for its pleasurable effects. This is due to the fact that they contain more THCA/THC depending on the scabies. A more accurate marker for undecarboxylated hemp flowers is THCA, but when the flowers are smoked, vaporized, or heated in some way, THCA or THC are used interchangeably and are essentially the same, which This is because THCA is converted to THC.

As described herein, the precise dosage formulation of a combination of one or more crystalline nicotine salts and one or more crystalline cannabinoids for use with the devices disclosed herein (onsert, precision rod and precision pod) is particularly suitable for use with the simultaneous use of tobacco and marijuana. It provides many types of hazardous abatement products for smokers. Tobacco enhances the pleasing effect of marijuana when both are smoked at the same time or immediately after smoking marijuana. This synergistic effect is due in part to the stimulating properties of nicotine, such as an increase in heart rate. Some smokers combine tobacco and marijuana into blunts or splits. Blunt is marijuana dried in tobacco leaf or cigar wrap containing tobacco, and split is also a joint containing tobacco. As blunts and splits burn, they produce 'tar' and noxious gases containing thousands of chemicals. For example, inhaling smoke by burning a high-purity form of crystalline CBDA or THCA, along with burning crystalline salts of nicotine, and without any hemp and tobacco plant material, is less harmful than inhaling smoke from blunts or splits. This is because blends of these pure or near-pure crystals result in significant reductions in mainstream smoke for a given level of cannabinoids and nicotine. Also, for example, vaping high purity, blended forms of crystalline THCA and crystalline nicotine salt in precision pods, with no propylene glycol and glycerin or very small amounts (compared to e-cigarettes), can be blunt or splattered. Less harmful than smoking leaf. Propylene glycol and vegetable glycerin, present in high percentages in e-liquids, are considered safe and acceptable substances as food additives; There are not enough data on long-term inhalation of these compounds. During the summer of 2019, reports of lungs irritated and inflamed from vaping e-liquids, including oils containing THC and vitamin E acetate, began to surface. Separately, the study showed that inhaling a nicotine-free e-cigarette aerosol transiently affected endothelial function in healthy nonsmokers. See Caporale et al. 2019, doi: 10.1148/radiol.2019190562. They highlight the usefulness of the devices disclosed herein for delivering concentrated formulations of active ingredients (eg, nicotine and cannabinoids) while eliminating or minimizing levels of carriers such as propylene glycol and glycerin. For a given dose of nicotine or THCA, whether smoking or vaping, for example, THCA and/or a salt of nicotine in its highly pure form, produces less smoke inhaled than Blunt or Split, and ) compared to vaping, there is less vapor inhaled.

Any extraction method known in the art is capable of producing the cannabinoid acid in crystalline or near crystalline form. These extracted cannabinoid acids, as determined by high performance liquid chromatography, are preferably at least 90% pure, more preferably at least 95% pure, more preferably at least 98% pure, more preferably at least 99% pure, and most preferably at least 99.5% pure. These extraction methods utilize liquid carbon dioxide (CO2) under supercritical or subcritical conditions, followed by at least one other further extraction, such as plant waxes, wax esters and optional glycerides, terpenes, carotenes, flavonoids and unsaturated fatty acid residues. including using an ethanol precipitation method that removes a substantial fraction of the residual non-cannabinoid material of See, for example, US Pat. Nos. 7,700,368 and 8,846,409.

9-테트라하이드로카나비놀산), CBDA(카나비디올산), CBCA(카나비크로멘산), CBGVA(카나비게로바린산), THCVA(테트라하이드로카나비바린산), CBDVA(카나비디바린산) 및 CBCVA(카나바이크로메바린산). 결정질 형태, 거의 결정질 형태, 다형성 결정질 형태, 및/또는 비정질 형태 여부에 관계없이, 임의의 니코틴의 염(니코틴 염)이, 다음으로부터 선택된 하나 이상을 포함하여 사용될 수 있다: 니코틴 4-아세트아미도벤조에이트, 니코틴 아스코르브산염, 니코틴 아스파르트산염, 니코틴 벤조에이트, 니코틴 중주석산염, 니코틴 염화물, 예컨대 니코틴 이염화수소산염 및 니코틴 염화수소산염, 니코틴 시트르산염, 니코틴 2,3-디하이드록시벤조에이트, 니코틴 3,5-디하이드록시벤조에이트, 니코틴 푸마르산염, 니코틴 겐티스산염 (2,5-하이드록시벤조산), 니코틴 글루타메이트, 니코틴 1-하이드록시-2-나프토에이트, 니코틴 3-하이드록시벤조에이트, 니코틴 락트산, 니코틴 레불린산, 니코틴 말산염, 니코틴 모노-피루브산염, 니코틴 뮤케이트, 니코틴 과염소산염, 니코틴 피루브산염, 니코틴 살리실산염, 니코틴 숙신산염, 니코틴 설페이트, 니코틴 타르타르산염 및 니코틴 염화아연.A combination of one or more cannabinoid acids and/or one or more nicotine salts may be included in an onsert, precision rod, or precision pod in any of the exemplary embodiments herein. Any cannabinoid acid, including those in crystalline or near crystalline form, may be used, including one or more cannabinoid acids selected from: CBGA (cannabigerolic acid), THCA (

9-tetrahydrocannabinolic acid), CBDA (cannabidiolic acid), CBCA (cannabichromenic acid), CBGVA (cannabigerovaric acid), THCVA (tetrahydrocannabivaric acid), CBDVA (cannabidivaric acid), and CBCVA (Canabichromevaric acid). Any salt of nicotine (nicotine salt), whether in crystalline form, nearly crystalline form, polymorphic crystalline form, and/or amorphous form, may be used, including one or more selected from: nicotine 4-acetamido benzoate, nicotine ascorbate, nicotine aspartate, nicotine benzoate, nicotine bitartrate, nicotine chloride such as nicotine dihydrochloride and nicotine hydrochloride, nicotine citrate, nicotine 2,3-dihydroxybenzoate, nicotine 3 ,5-dihydroxybenzoate, nicotine fumarate, nicotine gentisate (2,5-hydroxybenzoic acid), nicotine glutamate, nicotine 1-hydroxy-2-naphthoate, nicotine 3-hydroxybenzoate, nicotine lactic acid, nicotine levulinic acid, nicotine malate, nicotine mono-pyruvate, nicotine mucate, nicotine perchlorate, nicotine pyruvate, nicotine salicylate, nicotine succinate, nicotine sulfate, nicotine tartrate and.

Fragrance and additives

In addition to alkaloids and cannabinoids, the onserts, precision rods and precision pods disclosed herein may also contain optional flavorings and/or additives. As disclosed in U.S. Patent Application Serial No. 16/047,948, a method for facilitating conversion of a smoker to an electronic cigarette or tobacco heating product allows a smoker to personalize or flavor an ultra-low nicotine cigarette with an additive during the treatment period. Being able is important for smokers to better tolerate these unconventional cigarettes. For example, natural menthol crystals from peppermint oil or other mint oil may be included in any of the examples herein. The crystalline menthol is clear or white and becomes vapor when tobacco smoke passes through the crystals of the precision rod or when the precision pod is heated in a vaporizer to cause the menthol essence to permeate the mainstream vapor. Menthol crystals, as a solid, mix well with crystalline cannabinoid acids and crystalline salts of nicotine formulations. Any type of flavoring, whether in crystalline form or not, may be included in an onsert, precision rod or precision pot, and other examples that characterize flavor include vanilla (eg, vanillin), cherry, grape, mango, orange, clove, blueberry. , peach, cinnamon, coconut, licorice, chocolate, fruit, coffee, strawberry, pineapple, cucumber, lemon, lime, toffee. Commercial cigarettes, characterized and labeled as 'menthol', contain anywhere from about 2 mg to 20 mg of menthol. Any onsert, precision rod or precision pod contains at least 1 mg, 2 mg, 3 mg, 4 mg, 5 mg, 6 mg, 7 mg, 8 mg, 9 mg, 10 mg, 11 mg, 12 mg, 13 mg , 14 mg, 15 mg, 16 mg, 17 mg, 18 mg, 19 mg, 20 mg, 21 mg, 22 mg, 23 mg, 24 mg, 25 mg, 26 mg, 27 mg, 28 mg, 29 mg, 30 mg, 31 mg, 32 mg, 33 mg, 34 mg, 35 mg, 36 mg, 37 mg, 38 mg, 39 mg, 40 mg, 41 mg, 42 mg, 43 mg, 44 mg, 45 mg, 50 mg etc. and the like.

Additives are also important to improve some of the formulations of the onsert, precision rod and precision pod examples herein. For example, formulations of salts of crystalline cannabinoids and nicotine have no flavor or aroma, as all plant terpenes have been extracted or not present at all in the case of compounds being synthesized. Terpenes are stimulant oils that give hemp its unique aroma and taste. Every line has a unique terpene profile. These hemp terpenes can be reintroduced in the formulations of onserts, precision rods and precision pods to add characteristics such as taste and aroma to smoke or vapors. Although over 100 terpenes have been identified, the most common terpenes in cannabis include myrcene, caryophyllene, pinene, limonene and humulene.

The additive may also be used in the exemplary embodiment of the onsert, precision rod, or precision pod to improve any bitter taste of crystalline nicotine salts, other crystalline alkaloids, crystalline cannabinoids, and/or other crystalline compounds. The pH of the smoke or vapor produced from the formulation of the onsert, precision rod and precision pod is analyzed and adjusted accordingly by addition of ingredients to shift the pH of the smoke or vapor. For example, if the pH of the smoke produced from the formulation of the precision pod under development is greater than about 5.5, a weak acid such as a sugar, citric acid or fatty acid may be added to the formulation within the precision pod, precision rod or onsert. Plant materials or other ingredients may also be added to the formulations herein, including plant parts, plant fractions, or plant ingredients from medicinal herbs (eg, jasmine or ginseng), hemp, tobacco and/or other plants. do.

Other functional additives are useful, such as preservatives or non-tobacco alkaloids such as cytisine, also known as cytisinicline. Cytisine is a plant-based alkaloid present in many plant lineages, such as Cytisus and Laburnum (eg Cytisus laborinum or golden rain acacia). Citicycline has a high binding affinity for the nicotinic acetylcholine receptor. It is used as a smoking cessation drug in pill form in some European countries. In some exemplary embodiments, including at least 2 mg of citicinicline in an onsert, precision rod or precision pod, reduces the urge to smoke a conventional cigarette, and reduces the urge to smoke a conventional cigarette, when a smoker switches to an e-cigarette or tobacco heating product, or and to help stop nicotine use completely.

In some aspects of the invention, the nicotine content made in the factory is to facilitate the transition of smokers not interested in quitting tobacco and nicotine products completely from smoking conventional cigarettes to using e-cigarettes or cigarette heating devices. Products and formulations for improving the nicotine, anatabine and/or anabacin smoke yield (ie, levels) of smoking products such as this very low cigarette are provided for smokers. In this methodology, ultra-low nicotine cigarettes are used as a bridge between a smoker's predominant brand of cigarettes and an e-cigarette or between a smoker's predominantly brand of cigarettes and a cigarette heating device.

In another aspect, products and formulations for improving the nicotine smoke yield of conventional factory-made cigarettes are provided for smokers to reduce their exposure to cigarette smoke comprising 'tar' and carbon monoxide.

In another aspect, a product for adding new characteristic flavor(s) or enhancing the flavor(s) in the smoke of a tobacco product such as a cigarette is provided for a smoker.

In another aspect, a product for adding nicotine, anatabine and/or anabacin to a marijuana cigarette is provided for a smoker.

In another aspect, an article for inclusion of a cannabinoid or other additive or ingredient in a smoking article is provided for a smoker.

In another aspect, products and formulations are provided that allow smokers to enjoy the effects of cannabinoids and nicotine without exposure to non-nicotine tobacco compounds.

Example 1

Onsert for smoking products

To improve nicotine smoke yield, nicotine is combined with an onsert such that a consumer applies the onsert on, around, or inside a smoking product such as a cigarette. The nicotine adhered to or injected into the onsert is preferably in the form of a salt of nicotine. The onsert, made of cellulose (e.g., reconstituted hemp) or consisting of a wrapper comprising cellulose, can be approximately as long as a smoking product such as a cigar and can be of any shape or size including a width sufficient to wrap a cigarette. there is. 1A-1C , the onsert 1 comprising the cellulose wrapper 2 is configured to wrap around the entire circumference of the cigarette rod 3 of a factory-made cigarette. The width of the cellulosic wrapper 2 of the onsert 1 is larger than the circumference of the cigarette, so that both sides 4 and 5 of the onsert overlap the cigarette rod to sufficiently seal the cigarette. The self-adhesive (self-adhesive) side 6 of the onsert 1 has a self-adhesive adhesive around the entire perimeter (all four sides) 7 of the onsert, and attaches the onsert to a cigarette rod (3). It is rolled around the cigarette rod (3) while being pressed on. 1A and 1B , a nicotine salt (8) or any other form of nicotine (along with any other compounds or ingredients the onsert may include) is adhered to the onsert's cellulose wrapper (2) and , in this exemplary embodiment, there is no nicotine on the opposite side 9 of the onsert 1 . Alternatively, in some exemplary embodiments, nicotine and any other compound or ingredient are administered by methods known in the art, such as for reconstituting plant material (eg, reconstituted tobacco sheet or reconstituted hemp sheet). It is injected into the cellulose wrapper during the production process. In another exemplary embodiment, nicotine is enclosed between closed pockets (ie, envelopes or closed pouches) of opposing sheets by methods known in the art for producing sugar packets or silica gel packets.

As shown in FIG. 1C , the entire cigarette rod 3 is now wrapped in an onsert 1 . The onsert 1 and the cigarette are adhered to each other and the seal is improved by the smoker pressing along the length of the nicotine fortified cigarette at the joint 10 . The self-adhesive onserts may be packaged for supply in any form, such as a non-adhesive sheet (backing paper), each sheet comprising at least one onsert peeling off the non-adhesive sheet, or non-adhesive There may be self-adhesive onserts on a continuous roll of a series of multiple onserts peeling off the rolls one at a time from the backing paper. Self-adhesive onserts are preferred, although adhesives that activate when wetted (eg, applied with saliva) to adhere may be used. Any moisture activated adhesive known in the art may be used for the onsert.

When a cigarette is lit and smoked, some of the nicotine is transferred from the onsert into the mainstream smoke and becomes a part of it. Onsert includes any cellulosic material in the form of a wrapper or strip that is combustible and smokeable, such as paper or cellulosic material, cigarette paper, reconstituted tobacco sheet, including a form used to roll machine made cigars, reconstituted hemp sheet, hemp paper cellulosic materials made from other plants, such as hemp formulations, such as, and/or herbal plants (eg, ginseng or jasmine). An advantage of the onsert configuration of FIGS. 1A-1C is that other ingredients can be easily added to the onsert (between the onsert and the cigarette), after which the onsert can be completely dried around the cigarette.

In some exemplary embodiments, the onsert is fabricated by covering the onsert with a nicotine salt along with a binder, stabilizer, and/or adhesive known in the art. In this methodology, for example, about 3 parts gum arabic (derived from the acacia tree and also known as gum arabic or gum acacia) is mixed with about 1 part glycerin and about 1/6 parts water in a container for 15 minutes, It creates an adhesive that retains the nicotine salt in the onsert. A thin coat of binder, stabilizer or adhesive is formed on the same and/or opposite side of the self-adhesive side to adhere the onsert onto the cigarette and then applied to the uncut sheet (eg hemp paper). can When the nicotine salt is applied to the self-adhesive surface, nothing is applied where there is an adhesive, such as around the border 7 of the onsert, as shown in FIG. 1A. The nicotine salt covering in powder or flake form is then applied to one or both sides of the sheet at the desired rate immediately after application of the binder, stabilizer or adhesive to cause the nicotine salt coating to adhere to the sheet. After drying, a subsequent coating of binder, stabilizer or adhesive and nicotine salt may be applied to the sheet. A binder, stabilizer or adhesive may be applied as a final coat to better trap the nicotine on the sheet. The uncut sheet is then cut into multiple onserts to the desired shape and size. The onsert configured to wrap around the entire circumference of the smoking article may be of any size, for example, to completely wrap a cigar or 100 mm cigarette. Thus, the size and type of smoking article determines, in part, the size and construction of the onsert. In addition, the amount of nicotine salt (and/or other compound) applied to the onsert is based on the type and nature of the smoking product (eg, ventilation level) and the desired level of increase in nicotine yield (or the level of increase in yield of any other compound desired). do. Thus, the increase in nicotine yield (or other compound yield) is a function of the type and characteristics of the smoking product, and the type and size of the onsert used, including the level of compounds included in or on the onsert.

In another exemplary embodiment, the nicotine salt in combination with the other compound may be injected between two onsert sheets or between more than two onsert sheets, the onsert sheets being covered with the nicotine salt on the outer portion of each sheet. or not covered. In this fabrication arrangement, using the gum arabic formulation (or any other binder, stabilizer or adhesive formulation employed), two or more sheets or onserts after the sheets are subsequently cut into multiple onserts for packaging. can seal the edges of A self-adhesive onsert is preferably used in this embodiment for the consumer to peel and stick the nicotine onsert onto a cigarette or other smoking product. By covering the on-sert sheet with nicotine and not adhering, the nicotine in this fabrication arrangement is kept enveloping between the sheets, essentially for a cleaner consumer application.

The nicotine onserts disclosed herein (and precision rods and precision pods disclosed and described below) may also include other alkaloids, flavors, cannabinoids, terpenes, and/or other additives or ingredients. For example, any one of the exemplary embodiments herein, whether in a nicotine salt format, a nicotine co-crystal format, or a nicotine salt co-crystal format, includes the exemplary onsert examples of FIGS. 1A-1F . , using anatabine or anabacin in place of or in combination with nicotine. Both anatabine and anabacin are nicotine-like alkaloids, and instead of producing a nicotine salt, a salt of anatabine or a salt of anabacin can be produced for anatabine-fortified cigarettes and for anabacin-fortified cigarettes. The nicotine salt may be combined with an anabine salt and/or an anabacin salt, wherein the anabacin salt is combined with an anabacin salt for a marijuana cigarette or for cigarettes having any level or combination of enhanced nicotine, enhanced anatabine or enhanced anabacin. can be combined. Synthetic versions of these alkaloids may also be used.

9-테트라하이드로카나비놀산(

9-tetrahydrocannabinolic acid, THCA), 카나비디올산(cannabidiolic acid, CBDA), 카나비크로멘산(cannabichromenenic acid, CBCA), 카나비게롤산(cannabigerolic acid, CBGA), 테트라하이드로카나비바린산(tetrahydrocanabivarinic acid, THCVA), 카나비디바린산(cannabidivarinic acid, CBDVA), 카나비크로메바린산(cannabichromevarinic acid, CBCVA), 카나비게로바린산(cannabigerovarinic acid, CBGVA), 미르센(myrcene), 카리오필렌(caryophyllene), 피넨(pinene), 리모넨(limonene) 및 휴뮬렌(humulene)으로 이루어진 군으로부터 선택되는 하나 이상의 화합물을 포함할 수 있다. 각각의 온서트는 적어도 다음의 양의 전술한 화합물 각각을 포함할 수 있다: 0.10 mg, 0.20 mg, 0.30 mg, 0.40 mg, 0.50 mg, 0.60 mg, 0.70 mg, 0.80 mg, 0.90 mg, 1.0 mg, 1.1 mg, 1.2 mg, 1.3 mg, 1.4 mg, 1.5 mg, 1.6 mg, 1.7 mg, 1.8 mg, 1.9 mg, 2 mg, 3 mg, 4 mg, 5 mg, 6 mg, 7 mg, 8 mg, 9 mg, 10 mg, 11 mg, 12 mg, 13 mg, 14 mg, 15 mg, 16 mg, 17 mg, 18 mg, 19 mg, 20 mg, 21 mg, 22 mg, 23 mg, 24 mg, 25 mg, 26 mg, 27 mg, 28 mg, 29 mg, 30 mg, 31 mg, 32 mg, 33 mg, 34 mg, 35 mg, 36 mg, 37 mg, 38 mg, 39 mg, 40 mg, 41 mg, 42 mg, 43 mg, 44 mg, 45 mg, 46 mg, 47 mg, 48 mg, 49 mg, 50 mg, 51 mg, 52 mg, 53 mg, 54 mg, 55 mg, 56 mg, 57 mg, 58 mg, 59 mg, 60 mg, 61 mg, 62 mg, 63 mg, 64 mg, 65 mg, 66 mg, 67 mg, 68 mg, 69 mg, 70 mg, 71 mg, 72 mg, 73 mg, 74 mg, 75 mg, 76 mg, 77 mg, 78 mg, 79 mg, 80 mg, 81 mg, 82 mg, 83 mg, 84 mg, 85 mg, 86 mg, 87 mg, 88 mg, 89 mg, 90 mg, 91 mg, 92 mg, 93 mg, 94 mg, 95 mg, 96 mg, 97 mg, 98 mg, 99 mg, 100 mg, 110 mg, 120 mg, 130 mg, 140 mg, 150 mg, 160 mg, 170 mg, 180 mg, 190 mg, 200 mg, 250 mg 기타 등등. 예를 들어, 온서트는 적어도 30 mg의 니코틴을 함유할 수 있고, 위에 열거된 임의의 다른 성분을 함유하지 않을 수 있거나, 예를 들어, 적어도 10 mg 니코틴, 적어도 10 mg THCA 및 적어도 10 mg CBCA를 함유할 수 있다. 온서트는 하나 보다 많은 알칼로이드, 화합물 또는 첨가제를 함유할 수도 있다. 일부 예시적인 실시예에서, 도 1a에 도시된 온서트의 유형과 같은온서트는 구체적으로 MYO 또는 RYO 완제품 담배 블렌드를 포함하는 대마 및/또는 담배를 온서트 내로 직접 마는 데 사용될 수 있다. 다른 예시적인 실시예에서, 온서트는 전술한 하나 이상의 화합물 중 어느 하나를 포함하거나 포함하지 않고, 전술한 양(즉, 적어도 0.10 mg 내지 적어도 250 mg)의 종래의 담배, 저 니코틴 담배, 종래의 대마(즉, 마리화나) 및/또는 초저 THC 대마 중 어느 하나를 포함할 수 있다.Each onsert, of any type, contains nicotine, anatabine, anabacin, flavor,

9-tetrahydrocannabinolic acid (

9-tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA), cannabichromenenic acid (CBCA), cannabigerolic acid (CBGA), tetrahydrocanabivarinic acid (THCVA) , cannabidivarinic acid (CBDVA), cannabichromevarinic acid (CBCVA), cannabigerovarinic acid (CBGVA), myrcene, caryophyllene, pinene ), limonene and humulene may include one or more compounds selected from the group consisting of. Each onsert may contain each of the foregoing compounds in at least the following amounts: 0.10 mg, 0.20 mg, 0.30 mg, 0.40 mg, 0.50 mg, 0.60 mg, 0.70 mg, 0.80 mg, 0.90 mg, 1.0 mg, 1.1 mg, 1.2 mg, 1.3 mg, 1.4 mg, 1.5 mg, 1.6 mg, 1.7 mg, 1.8 mg, 1.9 mg, 2 mg, 3 mg, 4 mg, 5 mg, 6 mg, 7 mg, 8 mg, 9 mg, 10 mg, 11 mg, 12 mg, 13 mg, 14 mg, 15 mg, 16 mg, 17 mg, 18 mg, 19 mg, 20 mg, 21 mg, 22 mg, 23 mg, 24 mg, 25 mg, 26 mg , 27 mg, 28 mg, 29 mg, 30 mg, 31 mg, 32 mg, 33 mg, 34 mg, 35 mg, 36 mg, 37 mg, 38 mg, 39 mg, 40 mg, 41 mg, 42 mg, 43 mg, 44 mg, 45 mg, 46 mg, 47 mg, 48 mg, 49 mg, 50 mg, 51 mg, 52 mg, 53 mg, 54 mg, 55 mg, 56 mg, 57 mg, 58 mg, 59 mg, 60 mg, 61 mg, 62 mg, 63 mg, 64 mg, 65 mg, 66 mg, 67 mg, 68 mg, 69 mg, 70 mg, 71 mg, 72 mg, 73 mg, 74 mg, 75 mg, 76 mg , 77 mg, 78 mg, 79 mg, 80 mg, 81 mg, 82 mg, 83 mg, 84 mg, 85 mg, 86 mg, 87 mg, 88 mg, 89 mg, 90 mg, 91 mg, 92 mg, 93 mg, 94 mg, 95 mg, 96 mg, 97 mg, 98 mg, 99 mg, 100 mg, 110 mg, 120 mg, 130 mg, 140 mg, 150 mg, 160 mg, 170 mg, 180 mg, 190 mg, 200 mg, 250 mg and so on. For example, the onsert may contain at least 30 mg of nicotine and may not contain any of the other ingredients listed above, or may contain, for example, at least 10 mg nicotine, at least 10 mg THCA and at least 10 mg CBCA. may contain. An onsert may contain more than one alkaloid, compound or additive. In some demonstrative embodiments, an onsert, such as the type of onsert shown in FIG. 1A , specifically may be used to roll hemp and/or tobacco comprising a MYO or RYO finished tobacco blend directly into an onsert. In another exemplary embodiment, the onsert may or may not contain any of the one or more compounds described above, and in an amount (ie, at least 0.10 mg to at least 250 mg) of conventional tobacco, low nicotine tobacco, conventional hemp. (ie marijuana) and/or ultra-low THC hemp.

In some exemplary embodiments, the self-adhesive or moisture-activated adhesive is on the same side of the cellulosic wrapper with the one or more compounds, and in other embodiments, the adhesive is on the opposite side of the cellulosic wrapper with the one or more compounds. In another embodiment, the one or more compounds may be within an envelope, and the envelope may be centered on the cellulose wrapper. Onsert includes any of the above amounts (i.e., at least 0.10 mg to at least 250 mg) of nicotine, anatabine or anabacin; i.e. may comprise any compound or combination of compounds, including synthesized nicotine, anatabine, or anabacin, and the onsert may contain the above amounts (i.e., at least 0.10 mg to at least 250 mg) of one or more of the following cannabinoid acids. Can: Synthesized, ie produced outside the hemp plant, THCA, CBDA, CBCA, CBGA, CBGVA, THCVA, CBDVA and CBCVA.

Any strain, variety or blend of hemp may be enhanced by an onsert comprising one or more cannabinoids for rolling a marijuana strain, strain or blend of hemp flowers or other plant parts into an onsert such as the onsert type shown in FIG. 1A . can be This is sometimes required because the cannabinoid profiles of dozens of cannabinoids, including the THCA/CBDA ratio and content, of flowers of the same marijuana strain can vary significantly from one crop to another, especially when grown under different growing conditions. These onserts may be nicotine-free and tobacco-free, and are an ideal way to modify the cannabinoid profile of smoke from any strain, variety or blend of hemp flowers without the need for additional strains, varieties or blends of hemp flowers. For example, Onsert may provide a combination of THCA, CBDA, CBGA, THCA, CBDA, CBGA, etc. to allow cannabis users to fortify marijuana cigarettes, blunts, or splits or to alter the cannabinoid profile of smoke from any hemp strain, cultivar or blend to achieve a desired effect. and/or any other cannabinoids.

90 순수)인 경우에 그러하다. 실제로, (임의의 카나비노이드 중량에 더하여) 평균 약 650 mg의 담배인, 궐련(추가된 카나비노이드를 갖거나 갖지 않음)와 비교하여, 예를 들어, 온서트 내로 말린 20mg의 THCA, 10mg의 니코틴 염 및 200mg의 식물 재료(담배, 대마 또는 둘의 배합물인지 여부)를 포함하는 흡연 제품용 온서트는 식물 재료가 약 69% 적은 흡연 제품으로 변환된다. 이는 결과적으로 평균적인 궐련(추가된 카나비노이드를 갖거나 갖지 않음)와 비교하여, 온서트로부터의 '타르' 흡입을 포함하는 연기 흡입의 상당한 감소가 있을 것임을 의미한다. 또한, 온서트와 함께 담배가 덜 사용되기 때문에 발암성 TSNA의 상당한 감소가 있을 것이다.Rolling hemp and/or tobacco directly into the onsert, in addition to the benefit that any compound is present in the onsert, either included as a new compound not present in the smoking product, or provided as an adjunct to a compound already present in the smoking product. The on-sert design shown in FIG. 1A has other important advantages over conventional RYO cigarettes or RYO marijuana cigarettes. For example, the onsert is more convenient and less messy, especially when implemented as a self-adhesive onsert, and the onsert provides a seal on all four sides, preventing smoke dilution from unwanted airflow caused by loose rolls. Reduce. In addition, less tobacco or hemp may be used, particularly if the nicotine and/or cannabinoids included with the onsert are pure or semi-pure (e.g.,

90 pure). In fact, compared to cigarettes (with or without added cannabinoids), which average about 650 mg of tobacco (plus any cannabinoid weight), for example 20 mg of THCA, 10 mg of nicotine salt and Onserts for smoking products containing 200 mg of plant material (whether tobacco, hemp or a combination of the two) are converted into smoking products with about 69% less plant material. This means that there will consequently be a significant reduction in smoke intake, including 'tar' inhalation from onsert, compared to the average cigarette (with or without added cannabinoids). In addition, there will be a significant reduction in carcinogenic TSNA due to less use of tobacco with onsert.

In some demonstrative embodiments, synthetic nicotine may be the only active ingredient included with the onsert (or precision rod) so that hemp users can enjoy the benefits of nicotine (not derived from tobacco) with hemp. Onserts that provide nicotine in mainstream smoke from marijuana cigarettes (e.g., dried hemp with onserts such as onserts in Figures 1A-1C), whether synthetic nicotine or nicotine derived from the Nicotiana plant are used. or precision rod containing nicotine) effectively eliminates the need to contain any tobacco and consequently is a less harmful smoking product compared to Split, which has less plant material that needs to be burned as tobacco is not required for its nicotine content; This is because it reduces smoke inhalation and eliminates tobacco carcinogens such as TSNA.

It will be appreciated that the onserts herein may be of any shape or form, and that any self-adhesive adhesives on the onserts (or other adhesives such as those that require moisture for activation) may be continuous or any patterned. will be. For example, the self-adhesive adhesive is on all four sides 7 surrounding the nicotine salt 8 of the onsert 1 of FIG. 1A . In modified exemplary embodiments, one, two or three sides of the onsert may include a self-adhesive adhesive (or other adhesive, such as one that requires moisture for activation), or one or more additional adhesives Strips can be added, for example, via any axis of symmetry of the onsert. Any proportion of either side of the onsert may consist of adhesive. Onserts, including the onserts of FIGS. 1A-1F , may include a filter to be attached to one end of the onsert. Combustion accelerators or regenerative agents may be included during or on the onsert. Additionally, the onsert may also be placed inside an empty MYO cigarette tube or stuck inside RYO rolling paper before the smoker rolls or makes the smoking product (or loose tobacco or in the case of RYO or MYO). It will be understood that mixed in hemp) could be used more as an 'insert' in that it (ie, the on-insert is hidden after making a RYO smoking product or after making a MYO smoking product). When used in this manner, one or more alkaloids, flavors, cannabinoids, and other alkaloids, flavors, cannabinoids; Delivery rates of terpenes and/or other additives are generally higher. Of course, for onserts specially formulated for placement on the interior of a RYO or MYO smoking article, the self-adhesive adhesive feature can be of any type that is activated when wetted (eg, applied with saliva) to adhere to the smoking article. As with any other adhesive, it is optional. Embodiments of such exemplary onserts that may be inserted into a smoking article may not include any adhesive that adheres to the smoking article.

1D-1F show an exemplary configuration of a self-stick onsert composed of a cellulose wrapper that has a different shape than the onsert of FIGS. 1A-1C . 1D , the first type of onsert comprises a circular spear 11 having two wings 12 or four wings 13 , and contains one or more alkaloids, flavors, cannabinoids, terpenes and/or other Contains additives. Each of these onserts is positioned around a circular tip of a smoking article, such as a cigarette, cigar, or marijuana cigarette, and the wings, which may be of any length, extend and adhere to the smoking article. Another type is the elongate onsert 14 shown in FIG. 1E , which may be placed in parallel along the side of a smoking article, such as a cigar, for example, or one or both onserts may be wrapped around the smoking article. there is. In the exemplary embodiments of FIGS. 1D-1E , alkaloids, flavors, cannabinoids, terpenes, and/or other additives may be enveloped between closed pockets of opposing sheets of an onsert during the manufacturing process of the onsert, and may be incorporated into the adhesive. It may be adhered to any one side of the onsert by means of a method, or may be injected into the onsert.

Another type of onsert configuration is the web pattern onsert shown in the exemplary embodiment of FIG. 1F , similar to the onsert of FIGS. 1A-1C , wherein the onsert may be wrapped around a smoking article, such as a cigarette, or a cigarette; and/or may be used in conjunction with hemp to roll a cigarette, marijuana cigarette, blunt or split (RYO), or roll up and smoke by itself without any interdependent smoking product. On the self-adhesive adhesive side of the onsert 15, 1, 2, around the webbing 16, including alkaloids, flavors, cannabinoids, terpenes and/or other additives, wrapped in the webbing in front of the back sheet 17; There may be 3 or 4 adhesives. Discontinuous (ie, web) onserts of this type may be of any shape or size and may cover any portion of the smoking article.

In some demonstrative embodiments, the onsert may be included inside a pack of factory-made cigarettes, or may be tied together (eg, 20) and glued to the outside of the cigarette pack or rolling paper box as a packaging onsert. The advantage of packaging nicotine in or on factory-made cigarette packs is that, as outlined in U.S. Patent Application No. 16/047,948, the use of ultra-low nicotine cigarettes to exclusively convert from conventional cigarettes to e-cigarettes or tobacco heating devices is This is the convenience this packaging offers when some smokers may require supplemental doses of nicotine. These nicotine-fortified cigarettes (eg, nicotine onsert + ultra-low nicotine cigarettes) help the smoker exclusively use ultra-low nicotine cigarettes for the duration of treatment, as directed by the protocol, so that the smoker can use the ultra-low nicotine cigarettes exclusively for the duration of treatment. Do not cheat or smoke conventional cigarettes. The supplemental amount of nicotine provided by the nicotine onsert(s) can increase the nicotine smoke yield, for example, from 0.04 mg to 0.10 mg per cigarette. Although nicotine smoke exhibits a yield greater than twofold in this example, the nicotine yield of 0.10 mg is still dramatically lower than the nicotine yield of 1 mg of a conventional cigarette. Nicotine Onsert, which provides a supplemental amount of nicotine to conventional factory-made cigarettes, provides smokers with great flexibility to personalize their cigarettes to smoke each cigarette less. A nicotine fortified cigarette in which an onsert comprising nicotine is attached to a conventional cigarette reduces the tar-to-nicotine ratio.

Example 2

Precision rods for smoking products

A precision rod comprising precise amounts of one or more flavors, alkaloids, cannabinoids, terpenes and/or other additives, or ingredients, is inserted into the smoking article to release the one or more flavors, alkaloids, cannabinoids, terpenes and/or other additives, or ingredients. It is designed to remain in the smoking article during combustion of the smoking article for the purpose of transfer into the mainstream smoke produced by the smoke. Precision rods provide an accurately quantified formulation of a compound of interest, either as an adjuvant to the intrinsic content of one or more compounds already included in the smoking product, or as one or more new compounds. There are three types of precision rods. A first type of precision rod consists of a material that burns and burns as a smoking article, such as a cigar, burns. A suitable cellulosic material for this type of precision rod is one with an ignition temperature of 350°C or less. The ignition temperature is the lowest temperature at which a material begins to burn. These materials must also be hard enough (or made sufficiently rigid by design) to be able to be inserted, for example, into the tobacco end of a filtered cigarette, and to an unacceptable level for the mainstream smoke of smoking products. It should be capable of burning with smoking products without providing the toxin of Examples of suitable materials for cellulosic precision rods include, but are not limited to, fiberboard, paper, cardboard or other cellulosic or woody materials, which are preferably hemp or reconstituted hemp, tobacco or reconstituted tobacco, or Flavors, alkaloids, cannabinoids, terpenes, and/or other additives, or ingredients of interest, are produced from other plants that are adhered to or housed (contained) within chambers or hollow spaces within precision rods. In some exemplary embodiments of the precision rod (and precision pod), the compounds and ingredients are reconstituted hemp, reconstituted tobacco, or other plant material that is then reconstituted and then contained in the space or interior chamber of the precision rod (or compartment of the precision pod). included in

As shown in the exemplary embodiment of Figure 2a, the cellulosic precision rod 18 consists of six layers of multi-ply cardboard 19, each layer of multi-ply cardboard, for example, nicotine salt ( and/or any other compound), then all layers are bonded together by a binder or adhesive that is generally recognized as safe (GRAS) by the US Food and Drug Administration (FDA). A cellulosic precision rod may comprise one or more layers of cellulosic material. One or more layers of the cellulosic precision rods are bonded together during the production process of the layer(s) so that no additional binders or adhesives are required. The entire assembled precision rod can be covered with a thin GRAS coating or film to keep the compound sealed on the precision rod and out of the hands of the user. In another exemplary embodiment, one or two thick layers may be used for cellulosic precision rods, and these types of cellulosic precision rods using thick layers may also be used to accommodate higher amounts of nicotine salts and/or other compounds. It may include at least one chamber or hollow space.

A second type of precision rod in another exemplary embodiment is comprised of a material having an ignition temperature greater than 350°C without burning or burning as the smoking article burns. These precision rods are comprised of one or more flavors, alkaloids, cannabinoids, terpenes and/or other additives, or ingredients of interest, and are inserted into both ends of a smoking article to deliver these compounds or ingredients into the mainstream smoke produced by the smoking article. intended to remain in the smoking article during combustion of the smoking article. Examples of suitable refractory, rigid materials include, but are not limited to, fused quartz or silica, ceramics such as earthenware or porcelain, or non-toxic ultra-high temperature ceramics. Non-toxic metals or metal alloys, such as titanium or food grade stainless steel, may be used for embodiments where the precision rod will only squeak a few times so that it cannot escape the smoking article and burn the smoker.

As shown in FIG. 2B , there are three exemplary embodiments of cylindrical precision rods of various sizes that do not burn or burn as the smoking article burns, including a first precision rod 20 . These three precision rods consist of an inner chamber containing the compound and/or plant material. The inner chamber 21 starts at an opening at the end of the first precision rod 20 and has a diameter of about 1.25 mm and a length of about 13 mm. The first precision rod 20 contains about 15 mg of nicotine salt in powder form (density of about 900 kg/m 3 ) in the inner chamber 21 . One end of each precision rod may be pointed for easy insertion into any smoking article, such as a factory-made cigarette. The precision rod also includes one or more holes or vents leading to the inner chamber 21 . Each precision rod in Figure 2b has various holes 22 (only some of which are labeled). The number of holes or vents depends on the type of smoking article, the types and boiling points of compounds or components included in the precision rod, the amount of each compound in the precision rod, and the total weight of the contents in the precision rod. Holes or vents and end openings of the precision rod all lead to an internal chamber, which facilitates the flow of air, heat and smoke into and out of the precision rod. The end openings and holes or vents of the precision rod may be sealed with gum arabic or any GRAS material that melts readily when heated. The hole or vent may remain unsealed, in which case the particle size of the compound is made larger than the hole or vent and the compound is inserted through the end opening during production. The end opening may be covered with a peel-off tab that the consumer removes prior to inserting the precision rod into the smoking article. The entire precision rod can be sealed with plastic for the consumer to peel it off before use.

As shown in FIG. 2C , the precision rod 20 of FIG. 2B was inserted into the cigarette 23 . When a nicotine-fortified cigarette, which now contains a precision rod, is smoked, the orifices can release air, heat and heat as the nicotine (and/or other compounds in other exemplary embodiments) contained within the rod vaporizes and permeates into the mainstream smoke. Allow smoke to enter the precision rod. When the nicotine fortified cigarette 23 (or other smoking product in other embodiments) is partially smoked, the cigarette may be extinguished, or a precision rod may be ejected with the ash of the cigarette. A smoker will probably be satisfied with only a fraction of the nicotine fortified cigarettes being smoked (eg 40%) due to the adjuvant nicotine in a 15 mg precision rod. The smoker can discard the partially smoked cigarette, or save the unsmoked portion for later in case another precision rod can be inserted into the remainder of the cigarette. In either case, the smoker inhales approximately half of the smoke, including 'tar', compared to smoking the same cigarette without the precision rod. The amount of nicotine inhaled is about the same as if the same cigarette without the precision rod was smoked, since the average cigarette contains about 15 mg of nicotine; The same amount within the precision rod. In addition to reducing harm, smokers also have the option to benefit economically by purchasing fewer cigarettes, if the other half of each cigarette is saved.

The first two types of precision rods may also be inserted into the mouth end of a smoking article, which may be a filter of a smoking article such as a filtered cigarette or a filtered cigarette. For example, a precision rod comprising 8 mg of menthol crystals may be inserted into the mouth end (eg, filter end) of the cigarette. Holes or vents in the precision rod allow the essence of the menthol crystals to enter the mainstream smoke and deliver a menthol sensation and satisfaction to the smoker. Menthol or other flavor(s) in the precision rod increases the likelihood of accepting an ultra-low nicotine cigarette, since smoking an ultra-low nicotine cigarette has no serious effect on the throat compared to smoking a conventional cigarette, which It facilitates smokers completely quitting tobacco products, and facilitates smokers switching to e-cigarettes or tobacco heating devices (disclosed in US Patent Application Serial No. 16/047,948). E-cigarettes and tobacco heating devices are generally recognized to be much less harmful than smoking cigarettes. For example, vaping an e-cigarette is believed to be about 90% less harmful than smoking a cigarette.

A third type of precision rod is used with flavor injection systems. Precision rods of this type also contain one or more flavors, alkaloids, cannabinoids, terpenes and/or other additives, or ingredients, and are inserted into a smoking article, such as one or more cigarettes or cigars. The compound in the inner chamber is injected into the smoking article, and the precision rod is then removed from the smoking article. As shown in FIG. 2D , the flavor injection system includes a precision rod 24 and a plunger mechanism 25 . The plunger mechanism 25 includes a plunger not shown in FIG. 2D . The precision rod 24 includes a fastening mechanism at one end, which in this exemplary embodiment is a thread 26 that allows the precision rod to be threaded into the thread 27 of the plunger mechanism 25 . The precision rod includes an end aperture 28, which is the beginning of the inner chamber to receive the compound or ingredient prior to being injected into the smoking article. Once the precision rod 24 is inserted into the smoking article, then the precision rod and plunger mechanism 25 are connected (or the order can be reversed), and the plunger connected to the plunger mechanism is pushed into the plunger mechanism 25 . and the contents in the precision rod are emptied into the smoking article. When a smoking product is ignited, the mainstream smoke of the smoking product will be injected along with one or more compounds (and optional ingredients) currently included in the smoking product.

In some exemplary embodiments, the flavor injection system and precision rod are integral and need not be connected. Flavors, alkaloids, cannabinoids, terpenes and/or other additives or ingredients may be loaded directly into the plunger device or precision rod by a variety of methods. For example, the plunger can be removed from the plunger mechanism, and the compound and component are emptied or placed into the plunger mechanism passing through a precision rod. Then reattach the plunger. The flavor injection system is now ready to inject the smoking product along with the contents within the flavor injection system. Any of the foregoing exemplary embodiments of a flavor injection system may be automated with any type of machine in which one or more smoking products, eg, one or more cigarettes, are injected with the compound at one time or in series.

9-테트라하이드로카나비놀산(

9-tetrahydrocannabinolic acid, THCA), 카나비디올산(cannabidiolic acid, CBDA), 카나비크로멘산(cannabichromenenic acid, CBCA), 카나비게롤산(cannabigerolic acid, CBGA), 테트라하이드로카나비바린산(tetrahydrocanabivarinic acid, THCVA), 카나비디바린산(cannabidivarinic acid, CBDVA), 카나비크로메바린산(cannabichromevarinic acid, CBCVA), 카나비게로바린산(cannabigerovarinic acid, CBGVA), 미르센(myrcene), 카리오필렌(caryophyllene), 피넨(pinene), 리모넨(limonene) 및 휴뮬렌(humulene)으로 이루어진 군으로부터 선택되는 하나 이상의 화합물을 포함할 수 있다. 3가지 유형의 정밀 로드 각각은 적어도 다음의 양의 전술한 화합물 중 하나 이상을 포함할 수 있다: 0.10 mg, 0.20 mg, 0.30 mg, 0.40 mg, 0.50 mg, 0.60 mg, 0.70 mg, 0.80 mg, 0.90 mg, 1.0 mg, 1.1 mg, 1.2 mg, 1.3 mg, 1.4 mg, 1.5 mg, 1.6 mg, 1.7 mg, 1.8 mg, 1.9 mg, 2 mg, 3 mg, 4 mg, 5 mg, 6 mg, 7 mg, 8 mg, 9 mg, 10 mg, 11 mg, 12 mg, 13 mg, 14 mg, 15 mg, 16 mg, 17 mg, 18 mg, 19 mg, 20 mg, 21 mg, 22 mg, 23 mg, 24 mg, 25 mg, 26 mg, 27 mg, 28 mg, 29 mg, 30 mg, 31 mg, 32 mg, 33 mg, 34 mg, 35 mg, 36 mg, 37 mg, 38 mg, 39 mg, 40 mg, 41 mg, 42 mg, 43 mg, 44 mg, 45 mg, 46 mg, 47 mg, 48 mg, 49 mg, 50 mg, 51 mg, 52 mg, 53 mg, 54 mg, 55 mg, 56 mg, 57 mg, 58 mg, 59 mg, 60 mg, 61 mg, 62 mg, 63 mg, 64 mg, 65 mg, 66 mg, 67 mg, 68 mg, 69 mg, 70 mg, 71 mg, 72 mg, 73 mg, 74 mg, 75 mg, 76 mg, 77 mg, 78 mg, 79 mg, 80 mg, 81 mg, 82 mg, 83 mg, 84 mg, 85 mg, 86 mg, 87 mg, 88 mg, 89 mg, 90 mg, 91 mg, 92 mg, 93 mg, 94 mg, 95 mg, 96 mg, 97 mg, 98 mg, 99 mg, 100 mg, 110 mg, 120 mg, 130 mg, 140 mg, 150 mg, 160 mg, 170 mg, 180 mg, 190 mg, 200 mg, 기타 등등. 예를 들어, 정밀 로드는 적어도 30 mg의 아나타빈을 함유할 수 있고 위에 열거된 임의의 다른 성분을 함유하지 않을 수 있거나, 적어도 10 mg의 니코틴, 적어도 10 mg의 THCA 및 적어도 10 mg의 CBGVA를 함유할 수도 있다. 정밀 로드는 하나 보다 많은 알칼로이드, 화합물 또는 첨가제를 함유할 수 있다. 일부 예시적인 실시예에서, 세 가지 유형의 정밀 로드 각각은 전술한 하나 이상의 화합물 중 어느 하나를 포함하거나 포함하지 않고, 전술한 양 중 어느 하나, 즉 적어도 0.10 mg 내지 적어도 200 mg의 종래의 담배, 저 니코틴 담배, 종래의 대마(즉, 마리화나) 및/또는 초저 THC 대마를 더 포함할 수 있다.Each precision rod, of any of the three types, contains nicotine, anatabine, anabacin, flavor,

9-tetrahydrocannabinolic acid (

9-tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA), cannabichromenenic acid (CBCA), cannabigerolic acid (CBGA), tetrahydrocanabivarinic acid (THCVA) , cannabidivarinic acid (CBDVA), cannabichromevarinic acid (CBCVA), cannabigerovarinic acid (CBGVA), myrcene, caryophyllene, pinene ), limonene and humulene may include one or more compounds selected from the group consisting of. Each of the three types of precision rods may contain at least the following amounts of one or more of the foregoing compounds: 0.10 mg, 0.20 mg, 0.30 mg, 0.40 mg, 0.50 mg, 0.60 mg, 0.70 mg, 0.80 mg, 0.90 mg, 1.0 mg, 1.1 mg, 1.2 mg, 1.3 mg, 1.4 mg, 1.5 mg, 1.6 mg, 1.7 mg, 1.8 mg, 1.9 mg, 2 mg, 3 mg, 4 mg, 5 mg, 6 mg, 7 mg, 8 mg, 9 mg, 10 mg, 11 mg, 12 mg, 13 mg, 14 mg, 15 mg, 16 mg, 17 mg, 18 mg, 19 mg, 20 mg, 21 mg, 22 mg, 23 mg, 24 mg , 25 mg, 26 mg, 27 mg, 28 mg, 29 mg, 30 mg, 31 mg, 32 mg, 33 mg, 34 mg, 35 mg, 36 mg, 37 mg, 38 mg, 39 mg, 40 mg, 41 mg, 42 mg, 43 mg, 44 mg, 45 mg, 46 mg, 47 mg, 48 mg, 49 mg, 50 mg, 51 mg, 52 mg, 53 mg, 54 mg, 55 mg, 56 mg, 57 mg, 58 mg, 59 mg, 60 mg, 61 mg, 62 mg, 63 mg, 64 mg, 65 mg, 66 mg, 67 mg, 68 mg, 69 mg, 70 mg, 71 mg, 72 mg, 73 mg, 74 mg , 75 mg, 76 mg, 77 mg, 78 mg, 79 mg, 80 mg, 81 mg, 82 mg, 83 mg, 84 mg, 85 mg, 86 mg, 87 mg, 88 mg, 89 mg, 90 mg, 91 mg, 92 mg, 93 mg, 94 mg, 95 mg, 96 mg, 97 mg, 98 mg, 99 mg, 100 mg, 110 mg, 120 mg, 130 mg, 140 mg, 150 mg, 160 mg, 170 mg, 180 mg, 190 mg, 200 mg, etc. For example, a precision rod may contain at least 30 mg of anatabine and no other ingredients listed above, or contain at least 10 mg of nicotine, at least 10 mg of THCA and at least 10 mg of CBGVA. may contain. A precision rod may contain more than one alkaloid, compound or additive. In some exemplary embodiments, each of the three types of precision rods, with or without any one of the one or more compounds described above, contains any one of the preceding amounts, i.e., from at least 0.10 mg to at least 200 mg of conventional tobacco; It may further include low nicotine tobacco, conventional hemp (ie marijuana) and/or ultra low THC hemp.

In another exemplary embodiment, the precision rod comprises the aforementioned amounts (ie, at least 0.10 mg to at least 200 mg) of nicotine, anatabine, or anabacin not extracted from a Nicotiana plant; i.e. may comprise any one of synthesized nicotine, anatabine or anabacin, which may comprise the above amounts (i.e., at least 0.10 mg to at least 200 mg) of one or more of the following cannabinoid acids: Synthesized, i.e. , produced outside the hemp plant, THCA, CBDA, CBCA, CBGA, CBGVA, THCVA, CBDVA and CBCVA. For example, a precision rod may contain 30 mg of THCA and may not contain any of the other ingredients listed above, or it may contain 10 mg of nicotine, 10 mg of THCA and 10 mg of CBCA. . Precision rods may also contain one or more alkaloids, flavor or other additives.

The precision rod may be of any shape or length, and may depend in part on the amount of flavor, alkaloid, cannabinoid and/or other additives desired to be delivered to the mainstream smoke. An elongated shape with a pointed end is generally desirable for easy insertion into a smoking article such as a cigar. Precision rods, for example, can be 'pure' CBD and contain sugar-like CBDA crystals (eg 20 mg). Crystalline CBDA or any other crystalline cannabinoid can be prepared by various purification processes known in the art, such as, for example, by ethanol precipitation after a supercritical CO2 extraction process to remove residual impurities until the CBDA is approximately 99% pure. It may be provided by any method. The formulation can then be ground to a size of about 100 μm or larger, blended with other compounds or ingredients, and then incorporated into a precision rod. These precision rods can be used by smokers using ultra-low nicotine cigarettes to switch to e-cigarettes or tobacco heating products, or to quit cigarettes and nicotine products entirely; The method and product are disclosed in US Patent Application No. 16/047,948. Precision rods may contain flavors, alkaloids, cannabinoids and/or other additives, or any combination of ingredients. For example, and for entertainment purposes, a precision rod may contain 10 mg of nicotine, 10 mg of CBDA crystals, 20 mg of THCA crystals, and 10 mg of menthol crystals.

Any of the on-inserts, inserts, or precision rods disclosed herein are suitable for use in a Homemade Smoking (MIO) cigarette wherein the supplemental nicotine source can be placed inside an empty cigarette tube prior to filling the tube with tobacco, and the supplemental nicotine source prior to rolling the cigarette. can be applied to any type of cigarette, including direct roll smoking (RYO) cigarettes, which can be placed on the inside of a flat rolling paper. Alternatively, on-inserts, inserts, or precision rods may be used with MYO and RYO cigarettes (already filled with tobacco) similar to how they are used with factory-made cigarettes. Any of the on-inserts, inserts, or precision rods disclosed herein, whether these smoking products are factory-manufactured or hand-manufactured by the consumer, may be of any other type, such as cigar or marijuana smoking products (eg, joints). It can be applied to smoking products. For example, after removing some tobacco from the tobacco end of a factory cigarette, an onsert or precision rod may be placed within that tobacco end, and the portion of the removed tobacco may be placed back into the cigarette prior to lighting the cigarette. there is.

Example 3

Precision pods for vaporizers and smoking products

Tobacco and cannabis users, including product devices and formulations, consume solid or semi-solid forms of nicotine and cannabinoids, such as one or more crystalline cannabinoids, together with one or more crystalline alkaloids (with or without terpenes, flavor and other additives, or plant components). It lacks the ability to conveniently vape or smoke in precisely quantified amounts. A ready-to-vape or ready-to-smoker precision pod is configured for use with a vaporizer, pipe, rod, bowl, etc., for the purpose of conveniently vaping or smoking an accurate pre-measured and formulated amount of one or more compounds, wherein the precision pod comprises: includes such as cannabinoids and alkaloids, both cannabinoids and alkaloids in solid or semi-solid form. In some exemplary embodiments, precision formulations of the combined crystalline cannabinoid acid(s) and crystalline nicotine salt(s) of nicotine are provided in precision pods. Precision pods are advantageous in several ways, especially for those who smoke or vape tobacco and hemp, or those who double tobacco and hemp, although they may or may not necessarily smoke and vape at the same time.

From a hazard-reducing perspective, vaping crystalline cannabinoid acid(s) and crystalline nicotine salts from ready-to-vape precision pods is less expensive than vaping marijuana buds and cigarettes together or e-cigarettes and marijuana buds individually. harmful In the exemplary precision pod embodiment of the vaporizer, the active ingredient is much more concentrated in a solid or semi-solid form (e.g., a crystalline compound) contained in the precision pod, so that vaping tobacco and hemp together or separately is not recommended. In comparison, less vapor must be inhaled for a given dose of nicotine or cannabinoids in solid or semi-solid form. For example, e-liquids from e-cigarettes contain less than 6% nicotine (greater than about 95% inactive ingredients), and e-liquids from medical vaping pens typically contain less than 50% cannabinoids that are not crystalline. do. In contrast, precision pods do not contain any carriers such as propylene glycol or glycerin, or contain only enough (about 10 to about 17%) to mimic the moisture levels found in tobacco products or hemp buds. As a result, the ready-to-vape crystalline formulation of the compound in the precision pod is less harmful to the lungs because the active ingredient is much more concentrated and less vapors have to be inhaled for a given dose of nicotine or cannabinoid at a given dose. am.

Although propylene glycol and vegetable glycerin are generally recognized and designated as safe by the FDA (GRAS) for ingestion but not for inhalation as food additives; Although it is widely known that using e-cigarettes is less harmful than smoking (since smoke is produced and not inhaled), long-term data on inhaling large amounts of propylene glycol or vegetable glycerin from e-cigarettes are insufficient. High purity crystalline nicotine salt with a combination of a crystalline cannabinoid acid formulation, for example, containing no propylene glycol or glycerin, or containing low amounts of these carriers (eg, 5 to 15% by weight of the total formulation in the precision pod) Vaping may include vaping an e-liquid containing a very large proportion of propylene glycol and/or glycerin (eg, 90%), vaping the whole hemp flower, or vaping cannabinoids in less concentrated form. Compared to ping, it produces less alcoholic vapors, which are less harmful to the lungs.

Likewise, for those who prefer smoking rather than vaping, the ready-to-smoker precision pods allow smokers to inhale smoke from cannabinoids and nicotine in very pure form. Contains or does not contain solid or semi-solid crystalline cannabinoid acids (e.g., CBDA and/or THCA) and nicotine salts (terpenes, flavors, and/or other additives) contained in compartments of precision pods and smoked in pipes or bowls The ready-to-smoker precision pods containing a combination of causes Reducing smoke inhalation reduces harm because the dose is dependent on the cumulative level of tobacco smoke for tobacco-related diseases. In fact, the more non-tobacco substances (e.g., cannabinoids) in the filler of a conventional factory-made cigarette, the larger the smoker puffs per cigarette, the more puffs, or the more cigarettes they puff per day. are more likely to compensate for reduced nicotine levels, including Conventional cigarettes containing any significant portion of the cannabinoids in the filler can actually increase the harm to the smoker because the portion of the tobacco, and thus nicotine, is being reduced. By replacing 80-90% of cigarettes with cannabinoids, it would be impossible to reduce the nicotine levels in conventional cigarettes to the level of ultra-low nicotine cigarettes for which no compensation occurs, at which point the cigarettes will not function.

The ready-to-smoker precision pod enables smokers to achieve the same nicotine satisfaction with significantly less smoke and, importantly, carcinogenic tobacco-specific resulting from smoking blunt, split, or factory cigarettes containing cannabinoids. Free of nitrosamines (TSNA) and other tobacco-related compounds. When a form of synthetic nicotine is used, Precision Pods are 100% tobacco-free. In addition to being less harmful by reducing tobacco smoke exposure, compared to blunts, splits or other smoking products such as factory-made cigarettes containing cannabinoids, ready-to-smoker precision pods made of crystalline THCA/THC contain a given level of compounded compounds. And it eliminates speculation about the type and magnitude of the intoxicating effect on the ratio, since the formulation is consistent because of its level of purity. Ingredients such as flavors, terpenes and other additives, or plant ingredients (eg, minimal amounts of ultra-low THC hemp) may also be incorporated into the precision pod formulation at minimal levels.

As shown in FIG. 3A , the hexagonal prism-shaped precision pod 29 contains, within a compartment of the precision pod 29, a nicotine salt (which may contain any single or combination of the nicotine salts enumerated above), crystalline a blend of THCA, crystalline CBDA and menthol crystals. Appropriate levels of emollients are added to the formulation to remove smoke and remove roughness, and propylene glycol and/or glycerin may also be included to ensure that the formulation has an appropriate moisture level. About 12 to about 14% is the ideal moisture level for tobacco filler and hemp flowers. The moisture level of the formulation of the ready-to-smoker precision pod depends on many factors, including the boiling point temperature and amount of each compound (and any plant components) in the formulation, and the boiling point and total amount of the mixture. Different formulations may have different moisture levels. These compounds are formulated together to be in solid or semi-solid form. The precision pod may include two or more vents. The precision pod 29 of FIG. 3A includes multiple vents (only one is marked). The vents of the precision pod are for venting inlet air into the compartment and exhaust smoke out of the compartment.

9-테트라하이드로카나비놀산(

9-tetrahydrocannabinolic acid, THCA), 카나비디올산(cannabidiolic acid, CBDA), 카나비크로멘산(cannabichromenenic acid, CBCA), 카나비게롤산(cannabigerolic acid, CBGA), 카나비게로바린산(cannabigerovarinic acid, CBGVA), 테트라하이드로카나비바린산(tetrahydrocanabivarinic acid, THCVA), 카나비디바린산(cannabidivarinic acid, CBDVA), 카나비크로메바린산(cannabichromevarinic acid, CBCVA), 미르센(myrcene), 카리오필렌(caryophyllene), 피넨(pinene), 리모넨(limonene) 및/또는 휴뮬렌(humulene)으로 이루어진 군으로부터선택되는 둘 이상의 화합물을 포함할 수 있다. 각각의 즉시 베이핑 가능한 또는 즉시 흡연 가능한 정밀 포드는 적어도 다음의 양의 전술한 화합물 각각을 포함할 수 있다:0.10 mg, 0.20 mg, 0.30 mg, 0.40 mg, 0.50 mg, 0.60 mg, 0.70 mg, 0.80 mg, 0.90 mg, 1.0 mg, 1.1 mg 1.2 mg, 1.3 mg, 1.4 mg, 1.5 mg, 1.6 mg, 1.7 mg, 1.8 mg, 1.9 mg, 2 mg, 3 mg, 4 mg, 5 mg, 6 mg, 7 mg, 8 mg, 9 mg, 10 mg, 11 mg, 12 mg, 13 mg, 14 mg, 15 mg, 16 mg, 17 mg, 18 mg, 19 mg, 20 mg, 21 mg, 22 mg, 23 mg, 24 mg, 25 mg, 26 mg, 27 mg, 28 mg, 29 mg, 30 mg, 31 mg, 32 mg, 33 mg, 34 mg, 35 mg, 36 mg, 37 mg, 38 mg, 39 mg, 40 mg, 41 mg, 42 mg, 43 mg, 44 mg, 45 mg, 46 mg, 47 mg, 48 mg, 49 mg, 50 mg, 51 mg, 52 mg, 53 mg, 54 mg, 55 mg, 56 mg, 57 mg, 58 mg, 59 mg, 60 mg, 61 mg, 62 mg, 63 mg, 64 mg, 65 mg 66 mg, 67 mg, 68 mg, 69 mg, 70 mg, 71 mg, 72 mg, 73 mg, 74 mg, 75 mg 76 mg, 77 mg, 78 mg, 79 mg, 80 mg, 81 mg, 82 mg, 83 mg, 84 mg, 85 mg, 86 mg, 87 mg, 88 mg, 89 mg, 90 mg, 91 mg, 92 mg, 93 mg, 94 mg, 95 mg, 96 mg, 97 mg, 98 mg, 99 mg, 100 mg, 110 mg, 120 mg, 130 mg, 140 mg, 150 mg, 160 mg, 170 mg, 180 mg 190 mg, 200 mg, 250 mg, 300 mg, 기타 등등. 예를 들어, 정밀 포드는 적어도 10 mg의 CBDA, 적어도 5 mg의 니코틴 및 적어도 5 mg의 멘톨을 포함할 수 있다. 미국 특허 출원 번호 16/047,948에 개시된 바와 같이, 금연 치료로서 또는 흡연자를 담배 가열 제품 또는 전자 궐련으로 전환하는 것을 돕기 위해, 즉시 베이핑 가능한 또는 즉시 흡연 가능한 정밀 포드에 대해 상기 언급한 화합물 중 적어도 하나와 함께 임의의 상기 양(즉, 적어도 0.10 mg 내지 적어도 300 mg)의 저 니코틴 담배 및/또는 초저 THC 대마가 정밀 포드에 포함될 수있다. Each ready-to-vape or ready-to-smoker precision pod contains nicotine, anatabine, anabacin, flavor,

9-tetrahydrocannabinolic acid (

9-tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBA), cannabichromenenic acid (CBCA), cannabigerolic acid (CBGA), cannabigerovarinic acid (CBGVA), tetrahydrocanabivarinic acid (THCVA), cannabidivarinic acid (CBDVA), cannabichromevarinic acid (CBCVA), myrcene, caryophyllene, pinene ), limonene and/or humulene may include two or more compounds selected from the group consisting of. Each ready-to-vaporable or ready-to-smoker precision pod may contain each of the foregoing compounds in at least the following amounts: 0.10 mg, 0.20 mg, 0.30 mg, 0.40 mg, 0.50 mg, 0.60 mg, 0.70 mg, 0.80 mg, 0.90 mg, 1.0 mg, 1.1 mg 1.2 mg, 1.3 mg, 1.4 mg, 1.5 mg, 1.6 mg, 1.7 mg, 1.8 mg, 1.9 mg, 2 mg, 3 mg, 4 mg, 5 mg, 6 mg, 7 mg, 8 mg, 9 mg, 10 mg, 11 mg, 12 mg, 13 mg, 14 mg, 15 mg, 16 mg, 17 mg, 18 mg, 19 mg, 20 mg, 21 mg, 22 mg, 23 mg, 24 mg, 25 mg, 26 mg, 27 mg, 28 mg, 29 mg, 30 mg, 31 mg, 32 mg, 33 mg, 34 mg, 35 mg, 36 mg, 37 mg, 38 mg, 39 mg, 40 mg , 41 mg, 42 mg, 43 mg, 44 mg, 45 mg, 46 mg, 47 mg, 48 mg, 49 mg, 50 mg, 51 mg, 52 mg, 53 mg, 54 mg, 55 mg, 56 mg, 57 mg, 58 mg, 59 mg, 60 mg, 61 mg, 62 mg, 63 mg, 64 mg, 65 mg 66 mg, 67 mg, 68 mg, 69 mg, 70 mg, 71 mg, 72 mg, 73 mg, 74 mg, 75 mg 76 mg, 77 mg, 78 mg, 79 mg, 80 mg, 81 mg, 82 mg, 83 mg, 84 mg, 85 mg, 86 mg, 87 mg, 88 mg, 89 mg, 90 mg, 91 mg, 92 mg, 93 mg, 94 mg, 95 mg, 96 mg, 97 mg, 98 mg, 99 mg, 100 mg, 110 mg, 120 mg, 130 mg, 140 mg, 150 mg, 160 mg, 170 mg, 180 mg 190 mg, 200 mg, 250 mg, 30 0 mg, etc. For example, the precision pod may contain at least 10 mg CBDA, at least 5 mg nicotine, and at least 5 mg menthol. At least one of the compounds mentioned above for ready-to-vape or ready-to-smoker precision pods, as disclosed in U.S. Patent Application No. 16/047,948, as a smoking cessation treatment or to help convert smokers to tobacco heating products or e-cigarettes. Any of the above amounts (ie, at least 0.10 mg to at least 300 mg) of low nicotine tobacco and/or ultra low THC hemp may be included in the precision pod together with

In some exemplary embodiments, the precision pods contain any of the foregoing amounts (ie, at least 0.10 mg to at least 300 mg), nicotine, anatabine, or anabacin not extracted from a Nicotiana plant; That is, it may contain any one of synthesized nicotine, anatabine or anabacin, and the precision pod may contain two or more of the following cannabinoid acids in any of the above amounts (i.e., at least 0.10 mg to at least 300 mg): THCA, CBDA, CBCA, CBGA, THCVA, CBDVA, CBCVA and CBGVA synthesized, ie produced outside the hemp plant. In another exemplary embodiment, any of the foregoing amounts (i.e., at least 0.10 mg to at least 300 mg) of conventional tobacco, low nicotine tobacco, conventional hemp (ie, marijuana) and/or ultra-low THC hemp are of the following compounds: Can be included in an instant vapeable or ready to smoke precision pod with at least one: nicotine, anatabine, anabacin, flavor, THCA, CBDA, CBCA, CBGA, THCVA, CBDVA, CBCVA and CBGVA, myrcene, caryophyllene , pinene, limonene and/or humulene.

In some exemplary embodiments, the ready-to-vape or ready-to-smoker precision pods each contain at least 5 mg of tobacco (conventional or ultra-low nicotine) and/or at least 5 mg of hemp (marijuana or ultra-low THC hemp) and at least 2 mg of each. compounds described above, such as THCVA (tetrahydrocannabivaric acid). For ready-to-vape or ready-to-smoker precision pods (and onsert or precision rods) herein, low nicotine tobacco means a tobacco having a nicotine content of 3 mg/g or less, and ultra-low THC hemp 3 mg/g It means cannabis having a collective THCA/THC content of g or less.

Precision pods can be of any size or shape, including those designed for a particular model of carburetor, pipe, bowl or rod. The precision pod is configured for the oven chamber of a vaporizer or the tobacco or hemp chamber of a pipe, bowl or rod. Examples of suitable materials for the rigid precision pod include ceramics including fused quartz or silica, non-toxic ultra-high temperature ceramics, and any metal and preferably non-toxic metals or metal alloys such as titanium and food grade stainless steel; However, any material can be used for the precision pod, whether configured for a vaporizer or pipe, bowl or rod. The material used for the vaporizer may depend on the capacity or temperature range of the vaporizer as different materials, including metals, are heated at different rates. In some demonstrative embodiments, the precision pod is configured for a specific model of a vaporizer already on the market, or the precision pod and vaporizer are configured for each other during the product development phase of the newly designed vaporizer. In another exemplary embodiment, the generic precision pod is configured for multiple types of smoking articles or multiple types of vaporizers.

For precision pods configured for smoking products, materials that do not result in combustion or partial combustion are desirable; Materials that cause combustion may also be used and composed of paper-like materials such as reconstituted tobacco or other cellulosic materials such as those produced from hemp. This type of less rigid precision pod is useful for low dose compounds. Likewise, in the case of a precision pod configured for a vaporizer, it is preferred that only the contents within the compartment of the precision pod should be delivered to the mainstream vapor, and not the compound or component of the precision pod itself. One of the major advantages of the disposable ready-to-smoker or ready-to-vape precision pod is the convenience of precisely blending the desired compound in the correct proportions, whether rigid or not; However, in another exemplary embodiment, the precision pod may be reusable, in which case there may be an access panel that opens and closes with a fastener to provide access to remove used material and add fresh compound. The bottom of the precision pod may have legs, so that the ventilation of air from the bottom of the oven chamber of the carburetor or draft hole in the chamber of the bowl, pipe or rod is not blocked by the bottom of the precision pod. In some exemplary embodiments of the ready-to-vape precision pod, the vent in the bottom of the precision pod is configured to precisely align with the vent in the bottom of the oven chamber in the vaporizer. In another exemplary embodiment of the ready-to-smoker precision pod, the vent(s) in the bottom of the precision pod are configured to precisely align with the draft hole of the chamber in the bowl, pipe or rod. There may be one or more shelves within the compartment of the precision pod to keep the compound and any ingredients from lying on the bottom of the compartment. This depends on the types of compounds in the precision pod and their boiling points, the amount of total compound in the precision pod, whether any plant material is present in the precision pod, and whether the precision pod is specifically manufactured for a particular model of vaporizer or smoking product. depends on

As shown in FIG. 3B , a ready-to-smoker precision pod 31 is disposed within the bowl 32 and may be used with other smoking articles such as pipes or rods. The precision pod contains the exact blend of desired compounds and ingredients, allowing the blend within the compartment of the precision pod to heat, melt and burn uniformly. The exact combination of crystalline nicotine, crystalline cannabinoid acids (such as THCA and CBDA), menthol, and an emollient provides a dose of nicotine at a given dose compared to smoking a split, bluff, or factory cigarette containing, for example, cannabinoids. Or dramatically reduce the amount of smoke inhaled for a given dose of cannabinoid. This is because the concentration of nicotine in these formulations is higher, which makes the smoker compensate (ie titrate). Because some embodiments of ready-to-smoker precision pods do not contain hemp plant material (other than crystalline cannabinoids) or tobacco plant material (other than crystalline nicotine salts), less smoke and 'tar' are produced and inhaled, less Produces harmful products. In another exemplary embodiment, the precision pod does not contain any compounds or ingredients extracted or derived from tobacco; However, they contain synthetic nicotine which results in a tobacco-free and nicotine-free precision pod formulation.

As shown in FIG. 3C , while holding the vaporizer 33 , the oven cover 34 is removed from the top of the vaporizer 33 . An oven chamber 35 is exposed, in which case a ready-to-vape precision pod can be placed such that an exact amount of one or more compounds or two or more compounds plus the plant material(s) such as hemp can be vaporized. . As shown in FIG. 3D , the vaporizer 33 now includes an exemplary embodiment of a ready-to-vape precision pod 36 placed within the vaporizer's oven chamber 35 . The ready-to-vape precision pods contain the correct compound formulation within the compartment, and the precision pods are ready to use right out of the packaging. Four legs 37 are included on the precision pod to increase air and vapor flow at the bottom of the precision pod. When the vaporizer is powered on, the oven chamber 35 is heated and contains at least 5 mg of a crystalline salt of nicotine, at least 5 mg of crystalline cannabidioic acid (CBDA) and an emollient (e.g., smoothing vapors and reducing harshness). The contents of the precision pod are heated, including one or more food grade acids such as citric acid to remove). These solid or semi-solid formulations do not contain, or deliver into mainstream vapors, carcinogenic tobacco compounds such as TSNA. The ready-to-vape precision pod 36 of FIG. 3D reduces exposure to mainstream vapors as compared to vaping nicotine containing an e-cigarette, which results in a much higher concentration of nicotine in the mainstream vapor of the precision pod than in the e-liquid. Therefore, the person vaping the precision pod compensates by inhaling less steam accordingly. Likewise, compared to tobacco heating products, there is also a higher concentration of nicotine in the mainstream vapor from the precision pod, so less mainstream vapor needs to be inhaled per mg of nicotine desired, which means that the precision pod does not contain tobacco. Because it does not, the mainstream vapors of the precision pods are provided with the added benefit of not containing tobacco carcinogens.

Of course, each of the three products, the ready-to-vape precision pods, the e-cigarettes, and the tobacco-heating products, would reduce the harm compared to combustible cigarettes (with or without added cannabinoids), which in these three products. Because there is no burning, there is no cigarette smoke, which contains thousands of compounds that contain dozens of carcinogens. Another side benefit of the ready-to-vape precision pod is that the carburetor can keep the carburetor cleaner as compared to not using the carburetor, which means that much of the remaining used material is retained within the precision pod and , because it seeps into the vents at the bottom of the oven chamber of the carburetor, and the carburetor has to be cleaned less frequently.

In some exemplary embodiments, the precision pod comprises at least 5 mg of low nicotine tobacco and/or at least 5 mg of ultra-low THC hemp, such that a smoker can completely quit tobacco and nicotine products or use e-cigarettes, tobacco heating products, or precision pods. Helps switch to less harmful products such as See US Patent Application No. 16/047,948 for methods and various types of products for converting conventional cigarette smokers to less harmful products. Precision pods containing low nicotine tobacco and/or ultra low THC hemp are THCA, CBDA, CBCA, CBGA, THCVA, CBDVA, CBCVA, CBGVA, nicotine, anatabine, anabacin, myrcene, caryophyllene, pinene, limonene and At least 2 mg of one or more compounds selected from the group consisting of humulene may be further included. For example, a precision pod containing at least 50 mg of a low nicotine cigarette, at least 50 mg of ultra-low THC hemp, and at least 5 mg of CBDA has significantly less smoke exposure than an ultra-low nicotine cigarette containing about 600 mg of a low nicotine cigarette. causes

9-테트라하이드로카나비놀산(THCA)을 포함하는, 결정질 또는 거의 결정질 카나비노이드 산의 배합물, 및 (테르펜, 향미, 및/또는 다른 첨가제, 또는 식물 성분과 같은 성분을 포함하거나 포함하지 않는) 결정질 또는 근결정질 니코틴 염(들)은, 담배 독소에 대한 노출 및 편의 측면에서 담배 및 오락성 마리화나의 이중 사용자에게 유리하다. 카나비디올산(CBDA)을 포함하여, 결정질 또는 거의 결정질 카나비노이드 산의 배합물을 포함하는, 즉시 베이핑 가능한 정밀 포드는, 통증 완화를 추구하고 베이핑 펜으로부터 부피가 큰 증기를 흡입하고 싶지 않은 사람들에게 유리하다.For formulations of precision pods comprising addictive compounds such as THCA/THC, the type and magnitude of intoxication effects are predictable by using precision pods with precisely quantified, ready-to-vape or ready-to-smoker formulations. for example,

a combination of crystalline or nearly crystalline cannabinoid acids, including 9-tetrahydrocannabinolic acid (THCA), and crystalline (with or without ingredients such as terpenes, flavor, and/or other additives, or plant ingredients) or The myocrystalline nicotine salt(s) are advantageous to dual users of tobacco and recreational marijuana in terms of exposure and convenience to tobacco toxins. Containing a blend of crystalline or nearly crystalline cannabinoid acids, including cannabidiol acid (CBDA), ready-to-vape precision pods are ideal for those seeking pain relief and not wanting to inhale bulky vapors from a vaping pen. It is advantageous.

As the potency of hemp concentrates increases, precise dosing becomes more and more difficult, and THC effects can be highly variable. Consuming hemp concentrates, such as crystalline cannabinoids, waxes, budders, oils, arsenic or sap, is usually accomplished by 'dabbing', which is an extremely hot metal object such as a nail heated by a torch or the like. After placing the concentrate in the vapor is inhaled. In addition to being a risky and cumbersome procedure, obtaining the correct amount of concentrate is extremely difficult, often resulting in over-consumption and unpleasant effects. The potential safety concerns and potential poisoning effects of THC mixtures are often unknown, and actual poisoning effects can vary widely from batch to batch production of hemp concentrates. The THC ratio may be unknown or inaccurate, and the 'entourage effect' due to the interaction of various cannabinoids and impurities is difficult to predict. This disadvantage also arises from the concentrates used in the vaporizer.

The advantage of ready-to-smoker and ready-to-vape precision pods comprising one or more crystalline cannabinoid acids, as compared to dipping, is that each of the one or more crystalline cannabinoid acids is a ready-to-smoker or vaping cannabinoid acid without preparation. (up to about 99% pure) of precisely measured doses, and that precision pods deliver virtually consistent effects on the same person. In some exemplary embodiments of the precision pod, the aforementioned amount of THCA in milligrams, along with the purity level of THCA (weight of THCA divided by the total weight of compound and any additives or ingredients in the precision pod), is at least about 80 %, at least about 85%, at least about 90%, at least about 93%, at least about 95%, at least about 97%, at least about 98%, or at least about 99% so that the end user is given a given Allows you to know what effect is expected on the THCA content and THCA ratio of the formulation. For example, the effect of a precision pod containing 5 mg of nicotine salt, 50 mg of crystalline THCA and 20 mg of crystalline CBDA, 17.5 mg of ultra-low THC hemp (>0.30% THCA) and 7.5 mg of carrier and/or emollient. Its predictability and consistency are very beneficial to cannabis users who want precise, potent, and consistent effects with simultaneous THC/nicotine effects. The THC purity level of this 100 mg precision pod formulation is 50% (50 mg/100 mg). The nicotine/THC ratio is 10% and the CBD/THC ratio is 40%. When compared to dipping or vaping other concentrates, where cannabinoid percentages and THC levels are unknown or inconsistent in all production batches, ready-to-vape and ready-to-smoker precision pods containing crystalline cannabinoids achieve consistency of the concentrate. And it is beneficial for cannabis users who do not want to consume too much THC at once. Accurately measured amounts and proportions of purity of crystalline cannabinoids and crystalline nicotine forms combined with precision pods not only result in consistency and reduced hazard, but also the convenience of ready-to-smoker and ready-to-vape Precision Pods, compared to multiple vaping devices. or it is advantageous over using it.

The advantages of precision pods are readily apparent in overcoming biological constraints on cannabis plants that essentially produce a certain few cannabinoids and a certain percentage of cannabinoids. For example, tetrahydrocannabivaric acid (THCVA), which decarboxylates to tetrahydrocannabivarine (THCV), is a minor cannabinoid found at trace levels in most cannabis strains. Sativa strains tend to have higher THCVA content. THCV is an important appetite suppressant, a treatment for reducing panic attacks, and may be a treatment for nicotine dependence and possibly other types of dependence. Since THCV is a minority cannabinoid, it would be very difficult, if not impossible, if not impossible, to vape or bloom flowers from the hemp lineage that contain a THCVA to THCA ratio of at least 3/2 or a THCVA to CBDA ratio of at least 3/2. In some demonstrative embodiments, THCVA is extracted and separated for use in a precision pod (or onsert or precision rod) comprising a THCVA to THCA ratio of at least 3/2. In another exemplary embodiment, THCVA is extracted and separated for use in a precision pod (or onsert or precision rod) comprising a THCVA to CBDA ratio of at least 3/2. Tetrahydrocannabivaric acid (THCVA) can be synthesized and used in precision pods, precision rods and onserts.

It will be appreciated that any exemplary embodiment herein, whether pure machine, benchtop machine, or more substantially electrical type machine, may be automated by a machine. For example, in some demonstrative embodiments, the machine may provide a supplemental nicotine source (eg, precision rod) to multiple cigarettes at a time, such as a full pack of 20 cigarettes.

Certain precision rods, onserts, ready-to-vape precision pods and ready-to-smoker precision pods containing crystalline alkaloids may not be considered tobacco products in some jurisdictions because, among other reasons, they are derived from the tobacco plant. Because it contains no tobacco other than alkaloids, which may or may not be. The alkaloids of these articles may be synthesized so that none of the ingredients are derived from tobacco plants. Likewise, in some exemplary embodiments, the cannabinoids used in onserts, precision rods or precision pods can be synthesized and produced external to the cannabis plant. In another exemplary embodiment, a synthetic alkaloid and a synthetic cannabinoid are combined to create a formulation for use in an onsert , precision rod or precision pod that does not contain any nicotiana or cannabis plant material.

Claims (60)

A ready-to-vapor precision pod for use with a vaporizer configured to produce vapor from a dried herbal or concentrated plant extract for inhalation of vapor, said ready-to-vape precision pod comprising:
nicotine, anatabine, anabacin, flavor,

9-tetrahydrocannabinolic acid (

9-tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBA), cannabichromenenic acid (CBCA), cannabigerolic acid (CBGA), cannabigerovarinic acid (CBGVA), tetrahydrocanabivarinic acid (THCVA), cannabidivarinic acid (CBDVA), cannabichromevarinic acid (CBCVA), myrcene, caryophyllene, pinene ), each of two or more combined compounds equal to at least 1 mg selected from the group consisting of limonene and humulene;
a compartment containing said two or more combined compounds; and
one or more vents for venting air and vapor into and out of the compartment;
wherein the ready-to-vape precision pod is configured for placement into an oven chamber of the vaporizer. According to claim 1,
The two or more combined compounds are nicotine and

Precision pods ready to vape with 9-tetrahydrocannabinolic acid (THCA). 3. The method of claim 2,
Wherein the nicotine contains a nicotine salt, ready-to-vape precision pods. According to claim 1,
The two or more combined compounds are nicotine,

Precision pods ready for vaping with 9-tetrahydrocannabinolic acid (THCA) and cannabidiolic acid (CBDA). According to claim 1,
The two or more combined compounds are nicotine,

Ready-to-vape precision pods of 9-tetrahydrocannabinolic acid (THCA), cannabidioic acid (CBDA) and cannabichromenic acid (CBCA). According to claim 1,
Wherein the two or more combined compounds are nicotine and anatabine, ready-to-vape precision pods. According to claim 1,
The two or more combined compounds include anatabine and

Precision pods ready to vape with 9-tetrahydrocannabinolic acid (THCA). According to claim 1,
Wherein the two or more combined compounds are anatabine and cannabidioic acid (CBDA), ready-to-vape precision pods. According to claim 1,
The two or more combined compounds are anatabine,

Precision pods ready for vaping with 9-tetrahydrocannabinolic acid (THCA) and cannabidiolic acid (CBDA). A ready-to-vape precision pod for use with a vaporizer comprising:
nicotine, anatabine, anabacin, flavor,

9-tetrahydrocannabinolic acid (

9-tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBA), cannabichromenenic acid (CBCA), cannabigerolic acid (CBGA), cannabigerovarinic acid (CBGVA), tetrahydrocanabivarinic acid (THCVA), cannabidivarinic acid (CBDVA), cannabichromevarinic acid (CBCVA), myrcene, caryophyllene, pinene ), at least one compound equivalent to at least 1 mg selected from the group consisting of limonene and humulene;
at least 5 mg of hemp;
a compartment containing said one or more compounds and cannabis; and
one or more vents for venting air and vapor into and out of the compartment;
wherein the ready-to-vape precision pod is configured for placement into an oven chamber of the vaporizer. 11. The method of claim 10,
wherein said at least one compound is nicotine. 11. The method of claim 10,
wherein the at least one compound is tetrahydrocannabivaric acid (THCVA). 11. The method of claim 10,
The one or more compounds are

Precision pods ready to vape with 9-tetrahydrocannabinolic acid (THCA). A ready-to-smoker precision pod for use with a smoking article for inhalation of mainstream smoke comprising two or more compounds desired by a smoker, said ready-to-smoker precision pod comprising:
nicotine, anatabine, anabacin, flavor,

9-tetrahydrocannabinolic acid (

9-tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBA), cannabichromenenic acid (CBCA), cannabigerolic acid (CBGA), cannabigerovarinic acid (CBGVA), tetrahydrocanabivarinic acid (THCVA), cannabidivarinic acid (CBDVA), cannabichromevarinic acid (CBCVA), myrcene, caryophyllene, pinene ), each of two or more combined compounds equal to at least 1 mg selected from the group consisting of limonene and humulene;
a compartment containing said two or more combined compounds; and
one or more vents for venting air and the mainstream smoke into and out of the compartment;
wherein the smoking article comprises a pipe, bowl or rod;
wherein the ready-to-smoker precision pod is configured for placement into a chamber of the smoking article. 15. The method of claim 14,
The two or more combined compounds are nicotine and

Precision pods ready to smoke, 9-tetrahydrocannabinolic acid (THCA). 16. The method of claim 15,
Wherein the nicotine comprises a salt of nicotine, ready to smoke precision pod. 15. The method of claim 14,
The two or more combined compounds are nicotine,

Precision pods ready to smoke with 9-tetrahydrocannabinolic acid (THCA) and cannabidiolic acid (CBDA). 15. The method of claim 14,
The two or more combined compounds are nicotine,

Precision pods ready to smoke, which are 9-tetrahydrocannabinolic acid (THCA), cannabidioic acid (CBDA) and cannabichromic acid (CBCA). 15. The method of claim 14,
wherein said two or more combined compounds are nicotine salt and anatabine. 15. The method of claim 14,
The two or more combined compounds include anatabine and

Precision pods ready to smoke, 9-tetrahydrocannabinolic acid (THCA). 15. The method of claim 14,
wherein the at least two combined compounds are anatabine and cannabidioic acid (CBDA). 15. The method of claim 14,
The two or more combined compounds are anatabine,

Precision pods ready to smoke with 9-tetrahydrocannabinolic acid (THCA) and cannabidiolic acid (CBDA). A ready-to-smoker precision pod for use with a smoking article, said ready-to-smoker precision pod comprising:
nicotine, anatabine, anabacin, flavor,

9-tetrahydrocannabinolic acid (

9-tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBA), cannabichromenenic acid (CBCA), cannabigerolic acid (CBGA), cannabigerovarinic acid (CBGVA), tetrahydrocanabivarinic acid (THCVA), cannabidivarinic acid (CBDVA), cannabichromevarinic acid (CBCVA), myrcene, caryophyllene, pinene ), at least one compound equivalent to at least 1 mg selected from the group consisting of limonene and humulene;
at least 5 mg of tobacco;
a compartment containing said one or more compounds and said tobacco; and
one or more vents for venting air and smoke into and out of the compartment;
wherein the smoking article comprises a pipe, bowl or rod;
wherein the ready-to-smoker precision pod is configured for placement into a chamber of the smoking article. 24. The method of claim 23,
wherein said at least one compound is anatabine. 24. The method of claim 23,
wherein said at least one compound is cannabidioic acid (CBDA). 24. The method of claim 23,
wherein the at least one compound is tetrahydrocannabivaric acid (THCVA). 24. The method of claim 23,
The one or more compounds are

Precision pods ready to smoke, 9-tetrahydrocannabinolic acid (THCA). 24. The method of claim 23,
wherein said at least one compound is cannabigerolic acid (CBGA). 24. The method of claim 23,
wherein said at least one compound is anatabine and cannabidioic acid (CBDA). 24. The method of claim 23,
The one or more compounds are

9-tetrahydrocannabinolic acid (THCA),
wherein said cigarette contains less than 3 mg/g of nicotine. An onsert for application on, around, or within a smoking article for delivery of one or more compounds to the mainstream smoke of the smoking article, the onsert comprising:
cellulose wrapper;
an adhesive disposed on the cellulose wrapper to adhere the onsert to the smoking article; and
one or more compounds disposed on the cellulose wrapper, wherein the one or more compounds are nicotine, anatabine, anabacin, flavor;

9-tetrahydrocannabinolic acid (

9-tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBA), cannabichromenenic acid (CBCA), cannabigerolic acid (CBGA), cannabigerovarinic acid (CBGVA), tetrahydrocanabivarinic acid (THCVA), cannabidivarinic acid (CBDVA), cannabichromevarinic acid (CBCVA), myrcene, caryophyllene, pinene ), onsert equal to at least 1 mg individually selected from the group consisting of limonene and humulene. 32. The method of claim 31,
The smoking product is a cigarette, wherein the one or more compounds is nicotine. 33. The method of claim 32,
Onsert, wherein the nicotine comprises a nicotine salt. 32. The method of claim 31,
The smoking article is a cigarette, wherein the at least one compound is anatabine. 32. The method of claim 31,
wherein the smoking article is a cigarette, wherein the one or more compounds are

9-tetrahydrocannabinolic acid (THCA), Onsert. 32. The method of claim 31,
wherein the smoking article is a cigarette, wherein the at least one compound is cannabidioic acid (CBDA). 32. The method of claim 31,
wherein said smoking product is a cigarette, wherein said one or more compounds collectively equal at least 5 mg.

Onsert, which is 9-tetrahydrocannabinolic acid (THCA) and cannabidiolic acid (CBDA). 32. The method of claim 31,
The smoking article is a tobacco, and wherein the at least one compound is nicotine. 32. The method of claim 31,
The smoking article is a tobacco, wherein the one or more compounds is anatabine. 32. The method of claim 31,
wherein the smoking article is a cigarette, wherein the one or more compounds are

9-tetrahydrocannabinolic acid (THCA), Onsert. 32. The method of claim 31,
wherein the smoking article is a cigarette, and wherein the one or more compounds is cannabidioic acid (CBDA). 32. The method of claim 31,
wherein the smoking product is hemp, and wherein the one or more compounds is nicotine. 32. The method of claim 31,
The smoking product is hemp, and wherein the one or more compounds is anatabine. 32. The method of claim 31,
wherein the smoking article is hemp, wherein the one or more compounds are

9-tetrahydrocannabinolic acid (THCA), Onsert. 32. The method of claim 31,
wherein said smoking product is hemp, and wherein said at least one compound is CBDA. 32. The method of claim 31,
wherein said smoking product is hemp, wherein said one or more compounds are THCA and CBDA collectively equivalent to at least 5 mg. 32. The method of claim 31,
wherein the smoking product is a marijuana cigarette, wherein the at least one compound is nicotine. 32. The method of claim 31,
The smoking article is a marijuana cigarette, wherein the one or more compounds is anatabine. 32. The method of claim 31,
wherein the adhesive is self-adhesive. 32. The method of claim 31,
The adhesive is moisture-activated, on-sert. A precision rod for inserting one or more compounds into a smoking article for delivery to mainstream smoke of the smoking article, the precision rod comprising:
nicotine, anatabine, anabacin, flavor,

9-tetrahydrocannabinolic acid (

9-tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBA), cannabichromenenic acid (CBCA), cannabigerolic acid (CBGA), cannabigerovarinic acid (CBGVA), tetrahydrocanabivarinic acid (THCVA), cannabidivarinic acid (CBDVA), cannabichromevarinic acid (CBCVA), myrcene, caryophyllene, pinene ), limonene (limonene) and humulene (humulene) one or more compounds individually equal to at least 1 mg selected from the group consisting of;
an inner chamber containing the one or more compounds;
a flame retardant rigid material around the inner chamber having an ignition temperature greater than 350°C in which the one or more compounds are disposed; and
and at least one vent for venting inlet air into the precision rod and exhaust smoke out of the precision rod. 52. The method of claim 51,
wherein the smoking article is a cigarette, wherein the at least one compound is nicotine. 52. The method of claim 51,
wherein the smoking article is a cigarette, wherein the at least one compound is anatabine. 52. The method of claim 51,
wherein the smoking article is a cigarette, wherein the one or more compounds are

9-tetrahydrocannabinolic acid (THCA), precision rod. 52. The method of claim 51,
wherein the smoking article is a cigarette, wherein the at least one compound is cannabidioic acid (CBDA). A nicotine fortified cigarette comprising:
cigarette; and
contains a supplemental nicotine source;
wherein the supplemental nicotine source increases the nicotine yield of the cigarette by at least 10%. 57. The method of claim 56,
wherein the supplemental nicotine source is an onsert coupled to the cigarette. 57. The method of claim 56,
wherein the supplemental nicotine source is a precision rod inserted into the cigarette. A method of increasing the nicotine smoke yield of a factory made cigarette, the method comprising:
providing an onsert comprising nicotine;
wherein the onsert is configured to be applied onto or wrapped around the factory made cigarette. A method of increasing the nicotine smoke yield of a factory made cigarette, the method comprising:
providing a precision rod comprising nicotine;
wherein the precision rod is configured to be inserted into the factory made cigarette.

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