KR102519563B1 - precision pod - Google Patents

Abstract

Methods and apparatus for personalization of tobacco and cannabis smoking products including formulations for onserts, precision rods and precision pods, particularly for those who smoke or vape tobacco and marijuana simultaneously, as well as vaporizers for hazard reduction products A nicotine salt in crystalline form for a precision pod for use in medicine, and a method and apparatus for formulating one or more cannabinoids in crystalline form.

Description

precision pod

This disclosure relates to tobacco and hemp products.

[Cross Reference to Related Applications]

This application claims priority to United States Patent Application Serial No. 16/569,318, filed September 12, 2019 in the United States Patent and Trademark Office, the disclosure of which is incorporated herein by reference in its entirety.

Tobacco product manufacturers have the know-how and methods to produce products with a wide range of nicotine contents and alkaloid profiles. For example, they can produce cigarettes ranging from approximately 0.20 mg of nicotine per cigarette to at least 30 mg per cigarette. Both very low nicotine cigarettes and low tar-to-nicotine yield-ratio cigarettes are useful for tobacco harm reduction for different purposes; The former is intended to completely quit smoking and tobacco use or to convert smokers to smokeless tobacco products, the latter to smoke less. Tobacco product manufacturers' methods and know-how include genetic engineering and plant breeding techniques to reduce or increase the nicotine content in tobacco plants. Nicotine can also be extracted from tobacco for production of ultra-low nicotine cigarettes, or nicotine can be added for production of low tar-to-nicotine yield-ratio cigarettes. See, for example, U.S. Patent Nos. 3,612,066, 9,738,622, 9,814,258 and 10,113,174, which describe these methods used by tobacco product manufacturers to make factory manufactured tobacco products. On the other hand, tobacco end-users do not possess these methods or know-how capabilities; Nor do they have devices or alkaloids in suitable formulations for the convenient and economical addition of alkaloids, cannabinoids, flavors, or other additives to their smoking products, including cigarettes, cigars and marijuana cigarettes.

Conversely, some people, including those who do not smoke, smoke or vape both cigarettes and hemp at the same time, and find complementary and enhancing effects from the combination of the nicotine in tobacco and the cannabinoids in hemp. because there is Whether tobacco or cannabis is smoked or vaped individually or simultaneously, inhaling the smoke or vapors is the most efficient and quickest way to experience the effects of these compounds. A major problem with smoking or vaping tobacco and cannabis combinations is that many non-nicotine and non-cannabinoid compounds must be inhaled along with the nicotine and cannabinoids. This is especially the case when smoking a combination of tobacco and cannabis, or smoking a cigarette to which certain cannabinoids have been added, since in either case many carcinogenic tobacco compounds must be inhaled simultaneously with nicotine and cannabinoids. . Michael Russell, the father of tobacco harm reduction, is famous for saying, "People smoke for nicotine but they die from the tar." However, the use of tobacco in any form, including smokeless tobacco products, is not without risks, as it is carcinogenic, N-Nitrosonornicotine (NNN), 4-N-Nitrosonomethyl Amino-1-(3-pyridyl)-1-butanone (4-N-Nitrosomethylamino-1-(3-pyridyl)-1-butanone (NNK), N-Nitrosoanatabine (NAT) This is because tobacco contains tobacco-specific nitrosamines (TSNA), including , and N-Nitrosoanabasine (NNA). U.S. Patent No. 10,369,178 discloses tobacco products with added cannabinoids, but this disclosure in no way solves the problem of exposing smokers to TSNA and many tobacco carcinogens in order to enjoy the pleasurable effects of simultaneously consuming nicotine and cannabinoids. I never do that. Furthermore, this disclosure does not suggest any device that facilitates consumers to modify their factory manufactured cigarettes.

Thus, it allows consumers to (i) conveniently, economically and precisely personalize the nicotine, other alkaloids and/or flavoring content of factory-manufactured smoking products and (ii) enable immediate vaping without exposure to other tobacco compounds. It contains the right formulation to enjoy the pleasurable compound effect of a combination of nicotine, cannabinoids and other compounds in a ready-to-vape and ready-to-smoke precision pod. You need a product.

9-테트라하이드로카나비놀산(

9-tetrahydrocannabinolic acid, THCA), 카나비디올산(cannabidiolic acid, CBDA), 카나비크로멘산(cannabichromenenic acid, CBCA), 카나비게롤산(cannabigerolic acid, CBGA), 테트라하이드로카나비바린산(tetrahydrocanabivarinic acid, THCVA), 카나비디바린산(cannabidivarinic acid, CBDVA), 카나비크로메바린산(cannabichromevarinic acid, CBCVA), 카나비게로바린산(cannabigerovarinic acid, CBGVA), 미르센(myrcene), 카리오필렌(caryophyllene), 피넨(pinene), 리모넨(limonene) 및 휴뮬렌(humulene)으로 이루어진 군으로부터 선택된다.According to one embodiment of the present disclosure, an onsert is provided for application on, around or within a smoking article to deliver one or more compounds to the mainstream smoke of the smoking article, the onsert comprising a cellulose wrapper, smoking An adhesive disposed on a cellulose wrapper for adhering the onsert to an article, and one or more compounds disposed on the cellulose wrapper, each equivalent to at least 1 mg of said one or more compounds nicotine, anatabine, anabasin, spice,

9-tetrahydrocannabinolic acid (

9-tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA), cannabichromenenic acid (CBCA), cannabigerolic acid (CBGA), tetrahydrocanabivarinic acid (THCVA) , cannabidivarinic acid (CBDVA), cannabichromevarinic acid (CBCVA), cannabigerovarinic acid (CBGVA), myrcene, caryophyllene, pinene ), limonene and humulene.

In the case of an onsert, the smoking article may be a cigarette and the one or more compounds may be nicotine.

In an onsert, nicotine may include a nicotine salt.

In the case of an onsert, the smoking article may be a cigarette and the one or more compounds may be anatabine.

9-테트라하이드로카나비놀산(THCA)일 수 있다.In the case of an onsert, the smoking product may be a cigarette, and the one or more compounds may be

9-tetrahydrocannabinolic acid (THCA).

In the case of an onsert, the smoking article may be a cigarette and the one or more compounds may be cannabidiolic acid (CBDA).

9-테트라하이드로카나비놀산(THCA) 및 카나비디올산(CBDA)일 수 있다.In the case of an onsert, the smoking product may be a cigarette, and the one or more compounds collectively equal to at least 5 mg.

9-tetrahydrocannabinolic acid (THCA) and cannabidiolic acid (CBDA).

In the case of an onsert, the smoking product may be tobacco and the one or more compounds may be nicotine.

In the case of an onsert, the smoking product may be tobacco and the one or more compounds may be anatabine.

9-테트라하이드로카나비놀산(THCA)일 수 있다.In the case of an onsert, the smoking product may be tobacco, and the one or more compounds may be

9-tetrahydrocannabinolic acid (THCA).

In the case of an onsert, the smoking product may be tobacco and the one or more compounds may be cannabidiolic acid (CBDA).

In the case of an onsert, the smoking product may be hemp and the one or more compounds may be nicotine.

In the case of an onsert, the smoking product may be hemp and the one or more compounds may be anatabine.

9-테트라하이드로카나비놀산(THCA)일 수 있다.In the case of an onsert, the smoking product may be hemp, and the one or more compounds may be

9-tetrahydrocannabinolic acid (THCA).

In the case of an onsert, the smoking product may be hemp and the one or more compounds may be CBDA.

In the case of an onsert, the smoking product may be hemp, and the one or more compounds may collectively be THCA and CBDA equivalent to at least 5 mg.

In the case of an onsert, the smoking product may be a marijuana cigarette and the one or more compounds may be nicotine.

In the case of an onsert, the smoking product may be a marijuana cigarette and the one or more compounds may be anatabine.

In onsert, the adhesive may be self-adhesive.

On-sert, the adhesive can be moisture activated.

9-테트라하이드로카나비놀산(

9-tetrahydrocannabinolic acid, THCA), 카나비디올산(cannabidiolic acid, CBDA), 카나비크로멘산(cannabichromenenic acid, CBCA), 카나비게롤산(cannabigerolic acid, CBGA), 테트라하이드로카나비바린산(tetrahydrocanabivarinic acid, THCVA), 카나비디바린산(cannabidivarinic acid, CBDVA), 카나비크로메바린산(cannabichromevarinic acid, CBCVA), 카나비게로바린산(cannabigerovarinic acid, CBGVA), 미르센(myrcene), 카리오필렌(caryophyllene), 피넨(pinene), 리모넨(limonene) 및 휴뮬렌(humulene)으로 이루어진 군으로부터 선택되는 개별적으로 적어도 1 mg과 동등한 상기 하나 이상의 화합물, 및 상기 하나 이상의 화합물이 셀룰로오스 로드에 접착되거나 그 내부에 수용될 수 있는 350°C 미만의 점화 온도를 갖는 셀룰로오스 로드를 포함한다.According to one embodiment of the present disclosure, there is provided a precision rod for inserting one or more compounds into a smoking article for delivery to the mainstream smoke of the smoking article, the precision rod comprising nicotine, anatabine, anabasin, flavors,

9-tetrahydrocannabinolic acid (

9-tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA), cannabichromenenic acid (CBCA), cannabigerolic acid (CBGA), tetrahydrocanabivarinic acid (THCVA) , cannabidivarinic acid (CBDVA), cannabichromevarinic acid (CBCVA), cannabigerovarinic acid (CBGVA), myrcene, caryophyllene, pinene ), the one or more compounds individually selected from the group consisting of limonene and humulene, each equivalent to at least 1 mg, and a 350° angle at which the one or more compounds can be adhered to or accommodated in a cellulose rod. Cellulose rods having an ignition temperature below C.

For precision rods, the smoking article may be a cigarette and the one or more compounds may be nicotine.

In precision rods, nicotine may be a nicotine salt.

9-테트라하이드로카나비놀산(THCA)일 수 있다.For precision rods, the smoking product may be a cigarette, and the one or more compounds may be

9-tetrahydrocannabinolic acid (THCA).

In the case of a precision rod, the smoking article may be a cigarette and the one or more compounds may be cannabidiolic acid (CBDA).

9-테트라하이드로카나비놀산(THCA) 및 카나비디올산(CBDA)일 수 있다.For precision rods, the smoking product may be a cigarette, and the one or more compounds collectively equal to at least 5 mg.

9-tetrahydrocannabinolic acid (THCA) and cannabidiolic acid (CBDA).

In the case of a precision rod, the smoking product may be a marijuana cigarette and the one or more compounds may be nicotine.

In the case of a precision rod, the smoking article may be a cigarette and the one or more compounds may be anatabine.

9-테트라하이드로카나비놀산(

9-tetrahydrocannabinolic acid, THCA), 카나비디올산(cannabidiolic acid, CBDA), 카나비크로멘산(cannabichromenenic acid, CBCA), 카나비게롤산(cannabigerolic acid, CBGA), 테트라하이드로카나비바린산(tetrahydrocanabivarinic acid, THCVA), 카나비디바린산(cannabidivarinic acid, CBDVA), 카나비크로메바린산(cannabichromevarinic acid, CBCVA), 카나비게로바린산(cannabigerovarinic acid, CBGVA), 미르센(myrcene), 카리오필렌(caryophyllene), 피넨(pinene), 리모넨(limonene) 및 휴뮬렌(humulene)으로 이루어진 군으로부터 선택되는 개별적으로 적어도 1 mg과 동등한 상기 하나 이상의 화합물, 상기 하나 이상의 화합물을 수용하는 내부 챔버, 상기 하나 이상의 화합물이 배치될 수 있는 350°C 초과의 점화 온도를 갖는 상기 내부 챔버 주위의 난연성 강성 재료, 및 유입 공기를 상기 정밀 로드 내로 그리고 유출 연기를 상기 정밀 로드 밖으로 환기시키기 위한 적어도 하나의 통기구를 포함한다.According to one embodiment of the present disclosure, there is provided a precision rod for inserting one or more compounds into a smoking article for delivery to the mainstream smoke of the smoking article, the precision rod comprising nicotine, anatabine, anabasin, flavors,

9-tetrahydrocannabinolic acid (

9-tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA), cannabichromenenic acid (CBCA), cannabigerolic acid (CBGA), tetrahydrocanabivarinic acid (THCVA) , cannabidivarinic acid (CBDVA), cannabichromevarinic acid (CBCVA), cannabigerovarinic acid (CBGVA), myrcene, caryophyllene, pinene ), the one or more compounds individually selected from the group consisting of limonene and humulene, each equivalent to at least 1 mg, an internal chamber accommodating the one or more compounds, 350 in which the one or more compounds can be placed. a flame retardant rigid material around the inner chamber having an ignition temperature above °C, and at least one vent for venting incoming air into the precision rod and outgoing smoke out of the precision rod.

For precision rods, the smoking article may be a cigarette and the one or more compounds may be nicotine.

In precision rods, nicotine may be a nicotine salt.

9-테트라하이드로카나비놀산(THCA)일 수 있다.For precision rods, the smoking product may be a cigarette, and the one or more compounds may be

9-tetrahydrocannabinolic acid (THCA).

In the case of a precision rod, the smoking article may be a cigarette and the one or more compounds may be cannabidiolic acid (CBDA).

9-테트라하이드로카나비놀산(THCA) 및 카나비디올산(CBDA)일 수 있다.For precision rods, the smoking product may be a cigarette, and the one or more compounds may be

9-tetrahydrocannabinolic acid (THCA) and cannabidiolic acid (CBDA).

In the case of a precision rod, the smoking product may be a marijuana cigarette and the one or more compounds may be nicotine.

9-테트라하이드로카나비놀산(

9-tetrahydrocannabinolic acid, THCA), 카나비디올산(cannabidiolic acid, CBDA), 카나비크로멘산(cannabichromenenic acid, CBCA), 카나비게롤산(cannabigerolic acid, CBGA), 테트라하이드로카나비바린산(tetrahydrocanabivarinic acid, THCVA), 카나비디바린산(cannabidivarinic acid, CBDVA), 카나비크로메바린산(cannabichromevarinic acid, CBCVA), 카나비게로바린산(cannabigerovarinic acid, CBGVA), 미르센(myrcene), 카리오필렌(caryophyllene), 피넨(pinene), 리모넨(limonene) 및 휴뮬렌(humulene)으로 이루어진 군으로부터 선택되는 적어도 1 mg과 동등한 2개 이상의 배합된 화합물 중 각각, 상기 2개 이상의 배합된 화합물을 수용하는 구획부, 및 유입 공기를 상기 구획부 내로 그리고 유출 연기를 상기 구획부 밖으로 환기시키기 위한 하나 이상의 통기구를 포함하고, 여기서 상기 즉시 베이핑 가능한 정밀 포드는 상기 기화기의 오븐 챔버 내로 배치되도록 구성될 수도 있다.According to one embodiment of the present disclosure, a ready-to-vape precision pod is provided for use with a vaporizer configured to generate vapor from a dried herb or concentrated plant extract for simultaneous inhalation of two or more compounds, , The immediate vaping precision pod is nicotine, anatabine, anabasin, flavor,

9-tetrahydrocannabinolic acid (

9-tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA), cannabichromenenic acid (CBCA), cannabigerolic acid (CBGA), tetrahydrocanabivarinic acid (THCVA) , cannabidivarinic acid (CBDVA), cannabichromevarinic acid (CBCVA), cannabigerovarinic acid (CBGVA), myrcene, caryophyllene, pinene ), each of two or more blended compounds equivalent to at least 1 mg selected from the group consisting of limonene and humulene, a compartment accommodating the two or more blended compounds, and inlet air as described above. one or more vents for venting into the compartment and out of the compartment, wherein the ready-to-vape precision pod may be configured to be disposed into an oven chamber of the vaporizer.

9-테트라하이드로카나비놀산(THCA)일 수 있다.In a ready-to-vap precision rod, the two or more formulated compounds are nicotine and

9-tetrahydrocannabinolic acid (THCA).

In ready-to-vap precision rods, the nicotine may be a nicotine salt.

9-테트라하이드로카나비놀산(THCA), 및 카나비디올산(CBDA)일 수 있다.In a ready-to-vap precision rod, two or more formulated compounds may include nicotine,

9-tetrahydrocannabinolic acid (THCA), and cannabidiolic acid (CBDA).

9-테트라하이드로카나비놀산(THCA), 카나비디올산(CBDA), 및 카나비크롬산(CBCA)일 수 있다.In a ready-to-vap precision rod, two or more formulated compounds may include nicotine,

9-tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA), and cannabichromic acid (CBCA).

In a ready-to-vap precision rod, the two or more compounded compounds may be nicotine and anatabine.

9-테트라하이드로카나비놀산(THCA)일 수 있다.In a ready-to-vap precision rod, two or more formulated compounds are anatabine and

9-tetrahydrocannabinolic acid (THCA).

In a ready-to-vap precision rod, the two or more compounded compounds may be anatabine and cannabidiolic acid (CBDA).

9-테트라하이드로카나비놀산(THCA), 및 카나비디올산(CBDA)일 수 있다.In a ready-to-vap precision rod, two or more blended compounds are anatabine,

9-tetrahydrocannabinolic acid (THCA), and cannabidiolic acid (CBDA).

9-테트라하이드로카나비놀산(

9-tetrahydrocannabinolic acid, THCA), 카나비디올산(cannabidiolic acid, CBDA), 카나비크로멘산(cannabichromenenic acid, CBCA), 카나비게롤산(cannabigerolic acid, CBGA), 테트라하이드로카나비바린산(tetrahydrocanabivarinic acid, THCVA), 카나비디바린산(cannabidivarinic acid, CBDVA), 카나비크로메바린산(cannabichromevarinic acid, CBCVA), 카나비게로바린산(cannabigerovarinic acid, CBGVA), 미르센(myrcene), 카리오필렌(caryophyllene), 피넨(pinene), 리모넨(limonene) 및 휴뮬렌(humulene)으로 이루어진 군으로부터 선택되는 적어도 1 mg과 동등한 하나 이상의 화합물, 적어도 5 mg과 동등한 마리화나, 상기 하나 이상의 화합물 및 상기 마리화나를 수용하는 구획부, 및 유입 공기를 상기 구획부 내로 그리고 유출 연기를 상기 구획부 밖으로 환기시키기 위한 하나 이상의 통기구를 포함하고, 여기서 상기 즉시 베이핑 가능한 정밀 포드는 상기 기화기의 오븐 챔버 내로 배치되도록 구성될 수도 있다.According to one embodiment of the present disclosure, a ready-to-vape precision pod for use with a vaporizer is provided, wherein the ready-to-vape precision pod includes nicotine, anatabine, anabasin, flavors,

9-tetrahydrocannabinolic acid (

9-tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA), cannabichromenenic acid (CBCA), cannabigerolic acid (CBGA), tetrahydrocanabivarinic acid (THCVA) , cannabidivarinic acid (CBDVA), cannabichromevarinic acid (CBCVA), cannabigerovarinic acid (CBGVA), myrcene, caryophyllene, pinene ), at least one compound equivalent to at least 1 mg selected from the group consisting of limonene and humulene, marijuana equivalent to at least 5 mg, a compartment accommodating the one or more compounds and the marijuana, and inlet air into the compartment and one or more vents for venting escaping smoke out of the compartment, wherein the ready-to-vape precision pod may be configured to be disposed into an oven chamber of the vaporizer.

In a ready-to-vape precision rod, one or more of the compounds may be nicotine.

In a ready-to-vape precision rod, one or more of the compounds may be tetrahydrocanabivaric acid (THCVA).

9-테트라하이드로카나비놀산(THCA)일 수 있다.In a ready-to-vap precision rod, one or more compounds

9-tetrahydrocannabinolic acid (THCA).

9-테트라하이드로카나비놀산(

9-tetrahydrocannabinolic acid, THCA), 카나비디올산(cannabidiolic acid, CBDA), 카나비크로멘산(cannabichromenenic acid, CBCA), 카나비게롤산(cannabigerolic acid, CBGA), 카나비게로바린산(cannabigerovarinic acid, CBGVA), 테트라하이드로카나비바린산(tetrahydrocanabivarinic acid, THCVA), 카나비디바린산(cannabidivarinic acid, CBDVA), 카나비크로메바린산(cannabichromevarinic acid, CBCVA), 미르센(myrcene), 카리오필렌(caryophyllene), 피넨(pinene), 리모넨(limonene) 및 휴뮬렌(humulene)으로 이루어진 군으로부터 선택되는, 개별적으로 적어도 1 mg과 동등한 하나 이상의 화합물을 포함하고, 여기서 상기 플런저 기구는 상기 정밀 로드에 연결되고, 상기 정밀 로드는 하나 이상의 구멍 및 상기 하나 이상의 화합물을 수용하는 내부 챔버를 포함하고, 상기 플런저는 상기 정밀 로드 내의 하나 이상의 구멍을 통해 상기 화합물을 상기 흡연 제품의 주류연 내로 밀어냄으로써 상기 흡연 제품의 주류연에 상기 하나 이상의 화합물을 주입하도록 구성된다.According to one embodiment of the present disclosure, there is provided a flavor injection system for injecting one or more compounds into a smoking article to deliver the one or more compounds to the mainstream smoke of the smoking article, the flavor injection system comprising a plunger mechanism, into the smoking article. Precision rods for insertion, and nicotine, anatabine, anabasin, flavors,

9-tetrahydrocannabinolic acid (

9-tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA), cannabichromenenic acid (CBCA), cannabigerolic acid (CBGA), cannabigerovarinic acid (CBGVA), tetrahydrocanabivarinic acid (THCVA), cannabidivarinic acid (CBDVA), cannabichromevarinic acid (CBCVA), myrcene, caryophyllene, pinene ), at least one compound selected from the group consisting of limonene and humulene, individually equivalent to at least 1 mg, wherein the plunger mechanism is connected to the precision rod, and the precision rod comprises one one or more apertures and an inner chamber containing the one or more compounds, wherein the plunger pushes the one or more compounds into the mainstream smoke of the smoking article through the one or more apertures in the precision rod, thereby injecting the one or more compounds into the mainstream smoke of the smoking article. configured to inject.

According to one embodiment of the present disclosure, a method of increasing the nicotine smoke yield of a factory manufactured cigarette is provided, the method comprising providing an onsert comprising a salt of nicotine, wherein the onsert is within the factory manufactured cigarette. It may be for insertion.

According to one embodiment of the present disclosure, there is provided a method of increasing the nicotine smoke yield of a mill manufactured cigarette, the method comprising providing a precision rod comprising a salt of nicotine, wherein the precision rod comprises a mill manufactured cigarette It may be for insertion into.

According to one embodiment of the present disclosure, there is provided a nicotine-enhanced cigarette comprising a cigarette and a supplemental nicotine source connected to or inserted into the cigarette, wherein the supplemental nicotine source increases the nicotine yield of the cigarette by at least 10%.

The supplemental nicotine source may be an onsert connected to a cigarette.

The secondary nicotine source may be a precision rod inserted into the cigarette.

9-테트라하이드로카나비놀산(

9-tetrahydrocannabinolic acid, THCA), 카나비디올산(cannabidiolic acid, CBDA), 카나비크로멘산(cannabichromenenic acid, CBCA), 카나비게롤산(cannabigerolic acid, CBGA), 테트라하이드로카나비바린산(tetrahydrocanabivarinic acid, THCVA), 카나비디바린산(cannabidivarinic acid, CBDVA), 카나비크로메바린산(cannabichromevarinic acid, CBCVA), 카나비게로바린산(cannabigerovarinic acid, CBGVA), 미르센(myrcene), 카리오필렌(caryophyllene), 피넨(pinene), 리모넨(limonene) 및 휴뮬렌(humulene)으로 이루어진 군으로부터 선택되는, 적어도 1 mg과 동등한 2개 이상의 배합된 화합물 각각, 상기 2개 이상의 배합된 화합물을 수용하는 구획부, 및 유입 공기를 상기 구획부 내로 그리고 유출 연기를 상기 구획부 밖으로 환기시키기 위한 하나 이상의 통기구를 포함하고, 여기서 상기 흡연 제품은 파이프, 보울 또는 봉을 포함하고, 상기 즉시 흡연 가능한 정밀 포드는 상기 흡연 제품의 챔버 내에 배치되도록 구성될 수 있다.According to one embodiment of the present disclosure there is provided a precision smokeable pod for use with a smoking product for simultaneous inhalation of two or more compounds, the precision smokeable pod comprising nicotine, anatabine, anabasin, flavors ,

9-tetrahydrocannabinolic acid (

9-tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA), cannabichromenenic acid (CBCA), cannabigerolic acid (CBGA), tetrahydrocanabivarinic acid (THCVA) , cannabidivarinic acid (CBDVA), cannabichromevarinic acid (CBCVA), cannabigerovarinic acid (CBGVA), myrcene, caryophyllene, pinene ), each of two or more blended compounds equal to at least 1 mg selected from the group consisting of limonene and humulene, a compartment accommodating the two or more blended compounds, and inlet air as described above. one or more vents for venting into the compartment and out of the compartment, wherein the smoking article comprises a pipe, bowl or wand, and wherein the smokeable precision pod is disposed within a chamber of the smoking article. can be configured.

9-테트라하이드로카나비놀산(THCA)일 수 있다.In a ready-to-smoke precision pod, two or more blended compounds contain nicotine and

9-tetrahydrocannabinolic acid (THCA).

In a ready-to-smoke precision pod, the nicotine may be a nicotine salt.

9-테트라하이드로카나비놀산(THCA), 및 카나비디올산(CBDA)일 수 있다.In ready-to-smoke precision pods, two or more compounded compounds are nicotine,

9-tetrahydrocannabinolic acid (THCA), and cannabidiolic acid (CBDA).

9-테트라하이드로카나비놀산(THCA), 카나비디올산(CBDA), 및 카나비크로멘산(CBCA)일 수 있다.In ready-to-smoke precision pods, two or more compounded compounds are nicotine,

9-tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA), and cannabichromic acid (CBCA).

In a ready-to-smoke precision pod, the two or more compounds may be a nicotine salt and anatabine.

9-테트라하이드로카나비놀산(THCA)일 수 있다.In a ready-to-smoke precision pod, two or more blended compounds are anatabine and

9-tetrahydrocannabinolic acid (THCA).

In a ready-to-smoke precision pod, the two or more combined compounds may be anatabine and cannabidiolic acid (CBDA).

9-테트라하이드로카나비놀산(THCA), 및 카나비디올산(CBDA)일 수 있다.In ready-to-smoke precision pods, two or more compounded compounds are anatabine,

9-tetrahydrocannabinolic acid (THCA), and cannabidiolic acid (CBDA).

9-테트라하이드로카나비놀산(

9-tetrahydrocannabinolic acid, THCA), 카나비디올산(cannabidiolic acid, CBDA), 카나비크로멘산(cannabichromenenic acid, CBCA), 카나비게롤산(cannabigerolic acid, CBGA), 테트라하이드로카나비바린산(tetrahydrocanabivarinic acid, THCVA), 카나비디바린산(cannabidivarinic acid, CBDVA), 카나비크로메바린산(cannabichromevarinic acid, CBCVA), 카나비게로바린산(cannabigerovarinic acid, CBGVA), 미르센(myrcene), 카리오필렌(caryophyllene), 피넨(pinene), 리모넨(limonene) 및 휴뮬렌(humulene)으로 이루어진 군으로부터 선택되는, 적어도 1 mg과 동등한 하나 이상의 화합물, 적어도 5 mg과 동등한 초저 니코틴 담배, 상기 하나 이상의 화합물 및 상기 초저 니코틴 담배를 수용하는 구획부, 및 유입 공기를 상기 구획부 내로 그리고 유출 연기를 상기 구획부 밖으로 환기시키기 위한 하나 이상의 통기구를 포함하고, 여기서 상기 흡연 제품은 파이프, 보울 또는 봉을 포함하고, 상기 초저 니코틴 담배는 3 mg/g 미만의 니코틴을 포함하고, 상기 즉시 흡연 가능한 정밀 포드는 상기 흡연 제품의 챔버 내에 배치되도록 구성될 수 있다.According to one embodiment of the present disclosure, there is provided a precision smokeable pod for use with a smoking article, wherein the precision smokeable pod includes nicotine, anatabine, anabasin, flavors,

9-tetrahydrocannabinolic acid (

9-tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA), cannabichromenenic acid (CBCA), cannabigerolic acid (CBGA), tetrahydrocanabivarinic acid (THCVA) , cannabidivarinic acid (CBDVA), cannabichromevarinic acid (CBCVA), cannabigerovarinic acid (CBGVA), myrcene, caryophyllene, pinene ), at least one compound selected from the group consisting of limonene and humulene, equal to at least 1 mg, an ultra-low nicotine cigarette equal to at least 5 mg, a compartment containing said one or more compounds and said ultra-low nicotine cigarette. and one or more vents for venting incoming air into the compartment and outgoing smoke out of the compartment, wherein the smoking article comprises a pipe, bowl or wand, and wherein the ultra low nicotine cigarette is The smoke-ready precision pod comprising less than gram nicotine may be configured to be placed within a chamber of the smoking article.

In the ready-to-smoke precision pod, the one or more compounds may be anatabine.

In a ready-to-smoke precision pod, one or more of the compounds may be cannabidiolic acid (CBDA).

The above and/or other aspects of the present disclosure will become more apparent by describing specific embodiments of the present disclosure with reference to the accompanying drawings, of which:
1A is a top view of an exemplary embodiment of a self-adhesive onsert for a cigarette;
FIG. 1B is a perspective view of the self-adhesive onsert of FIG. 1A partially wrapped around a cigarette;
1C is a top view of the self-adhesive onsert of FIGS. 1A and 1B fully wrapped and glued around the cigarette;
1D is a top view of two exemplary embodiments of self-adhesive onserts;
1E is a top view of an exemplary embodiment of a self-adhesive onsert;
1F is a top view of an exemplary embodiment of a self-adhesive onsert;
2A is an exploded front view of an exemplary embodiment of a precision rod and an exploded view of the assembled precision rod;
2B is a perspective view of exemplary embodiments of precision rods, each having various sizes;
2C is a top view of an exemplary embodiment of a precision rod inserted into a cigarette;
2D is a perspective view of an exemplary embodiment of a flavor injection system;
3A is a perspective view of an exemplary embodiment of a smokeable precision pod for a bowl or pipe;
Fig. 3b is a perspective view of the smokeable precision pod of Fig. 3a placed in a smoking article, i.e. bowl;
3C is a perspective view of a prior art vaporizer with the oven cover removed exposing the oven chamber; and
FIG. 3D is a perspective view of an exemplary embodiment of a ready-to-vape precision pod placed within the oven chamber of the prior art vaporizer of FIG. 3C.

The devices and formulations disclosed herein enable tobacco and hemp end-users to conveniently, economically and accurately personalize the content of nicotine, cannabinoids, flavorings and/or other additives in mainstream smoke from vaporizers and mainstream smoke from their smoking products, such as cigarettes. This allows them to satisfy product preferences and taste preferences independent of manufacturers' product offerings in a given market. Ultra-low nicotine cigarettes are an important tool for converting smokers to e-cigarettes or tobacco heating products and for smokers to quit cigarettes and nicotine products completely; Therefore, ultra-low nicotine cigarettes, along with e-cigarettes and tobacco heating products, have great potential for tobacco harm reduction. Since the rate of nicotine metabolism varies greatly among different groups of smokers, consumers who have the ability to slightly increase the nicotine content of, for example, their ultra-low nicotine cigarettes are important. The devices and formulations disclosed herein allow consumers to modify the compounds in the smoke from smoking products and to precisely personalize the compounds in the vapor from vaporizers to their preferences.

With regards to ultra-low nicotine cigarettes, these variations are intended to provide more, while attempting to quit cigarettes and nicotine products entirely, or to switch to less harmful products such as e-cigarettes or ready-to-vape precision pods that contain a unique blend of compounds. A proportion of smokers can tolerate these cigarettes and only smoke them (without smoking any conventional cigarettes). For methods of helping smokers transition to e-cigarettes or tobacco heating devices or helping smokers quit cigarettes and nicotine completely, as well as various types of ultra-low nicotine cigarettes and other products, see US Patent Application Serial No. 16/047,948.

In a phase 3 clinical trial published in the Journal of the American Medical Association to determine whether there were differences in biomarkers of smoke exposure between immediate and gradual reductions in nicotine content in cigarettes, immediate reductions in nicotine were associated with greater It resulted in withdrawal symptoms, greater use of non-study conventional cigarettes, and higher dropout rates. For these study subjects, the immediate reduction to ultra-low nicotine cigarettes containing cigarettes with 0.4 mg/gram of nicotine (the nicotine content per cigarette is approximately 0.3 mg) is likely to have caused the nicotine reduction to be too low too quickly. See JAMA , September 4, 2018, Vol. 320, No. 9, pp. 880-891. Some of these subjects who left this study (and other studies using ultra-low nicotine cigarettes) were placed on a device that provided a supplemental nicotine source that was readily connected to their ultra-low nicotine cigarettes and delivered to mainstream smoke, if smokers needed it. If you had access to it, it's possible you'd have completed your research. Mainstream smoke is smoke that is inhaled, including smoke that comes out of a smoker's mouth as a result of the smoker smoking a smoking product or from the mouth end of a smoking product (eg, the filter end of a filter cigarette). The amount of nicotine provided for this purpose will be very small.

In a phase 2 clinical trial to investigate the effect of reduced nicotine cigarettes on smoking behavior, toxic exposure, dependence and withdrawal, there were three interventions: (i) 0.05 mg nicotine yield cigarettes (ultra-low nicotine content cigarettes) of 6 weeks; (ii) 0.3 mg nicotine yield cigarettes (low nicotine content cigarettes with approximately 6 times the nicotine content of ultra low nicotine cigarettes), and (iii) 4 mg nicotine candy. The dropout rate was the highest at 48% for the nicotine candy arm, but the second highest dropout rate at 40% for the 0.05 mg nicotine yield cigarette arm, followed by the 0.3 mg nicotine yield cigarette arm at 25%. Since withdrawal was considered a treatment failure, it would have been beneficial to reduce dropout rates among those using ultra-low nicotine cigarettes, since the ultra-low nicotine cigarette arm had the highest withdrawal rate after treatment of the three interventions. am. See Hatsukami et al., 2010, Addiction , 105(2):343-55. If people in the ultra-low nicotine cigarette arm of the study had access to a product that could easily be plugged into their ultra-low nicotine cigarettes to slightly increase nicotine in mainstream smoke as needed, they would have had lower dropout rates and higher quit rates.

For smokers not interested in quitting smoking or switching to smokeless products, increasing the nicotine content of a conventional cigarette results in an increased concentration of nicotine resulting in a lower tar-to-nicotine yield-ratio and reduced smoke inhalation. Since cigarettes with a tar-to-nicotine yield ratio (the 'tar' machine yield divided by the nicotine machine yield, which may be the ISO method or other methods) of approximately 8 or less are not currently marketed by tobacco companies, their factory-manufactured conventional Consumers who increase the nicotine yield of their cigarettes are advantageous in the case of those who want to reduce the harm caused by their smoking but are unable or unwilling to quit smoking. Conventional cigarettes typically have a tar-to-nicotine yield ratio of 10 to 14 (e.g. ISO 13 mg 'tar' yield and 1 mg nicotine yield), which in this example is for every 1 mg of nicotine: This means that a smoker has to inhale about 13 mg of 'tar'. It is important to note that people smoke for nicotine, but smoking-related diseases result from smoke containing 'tar'. Reducing the amount of smoke reduces the damage.

Due to compensatory smoking behavior, compared to conventional cigarettes, exposure to harmful "tar" and gases is reduced by nicotine-enhanced cigarettes (defined below), while exposure to nicotine remains approximately the same . Although there is variation, smokers generally want approximately 1 mg of nicotine per cigarette, and any more nicotine per cigarette than the smoker wants is an unpleasant experience. Smokers easily titrate smoke exposure when smoking nicotine-enhanced cigarettes by taking smaller puffs and fewer puffs per cigarette. Conventional cigarettes with improved nicotine yield in mainstream smoke by the embodiments herein, compared to conventional cigarettes with no improved nicotine yield, allow smokers to obtain approximately 1 mg of nicotine per cigarette (or any cigarette the smoker deems acceptable). of different amounts per cigarette) more efficiently and make the smoker inhale less smoke. See, for example, Armitage et al., 1998, Psychopharmacology , 96:447-453; Fagerstrom 1982, Pharmacology , 77:164-167; Russell MA, Nicotine and Public Health , Chapter 15, American Public Health Organization, 2000; and Pandolfino 2005, Presentation on October 19, 2005 at Life Science Research Organization (LSRO), Reducing the Adverse Health Impact of Cigarettes on Smokers Who Will Not or Cannot Abstain Through Modification of Leaf Nicotine Content available for download from the LSRO website.

Now, a conventional cigarette with a tar-to-nicotine yield ratio of 13, including a sufficient secondary nicotine source (e.g., a precision rod containing 18 mg of nicotine inserted into the cigarette), has a tar-to-nicotine yield ratio of less than 8 Nicotine-fortified cigarettes with yield ratios are produced. As a result, smokers inhale significantly less smoke, including less 'tar'. The exact tar-to-nicotine yield ratio depends on the characteristics for which the cigarette is fortified, including overall ventilation, filter type, additive level, etc.

8의 저 타르-대-니코틴 수율 비). 여기에는 시장에 나와 있는 기존 제품의 판매를 잠식하지 않기로 한 기업의 결정, 기술 또는 지식 재산권의 부족, 원자재의 고비용 또는 제한된 가용성, 제조업체가 제품을 판매하는 것을 금지하는 법률 또는 규정(소비자가 공장 제조 제품을 제조하거나 변형하지는 않음) 및/또는 시장 내 수요 수준이 제품을 출시하는 데 필요한 대규모 자본 지출(예: 필수 기계류)을 정당화하지 못할 수 있는 것이 포함된다.There are various reasons why manufacturers do not offer certain products to consumers despite demand (e.g.

low tar-to-nicotine yield ratio of 8). These include a company's decision not to cannibalize sales of an existing product on the market, a lack of technology or intellectual property rights, the high cost or limited availability of raw materials, and laws or regulations prohibiting manufacturers from selling their products (consumers are factory manufactured). does not manufacture or modify the product) and/or where the level of demand within the market may not justify the large capital expenditure required to bring the product to market (eg essential machinery).

The terms 'about' or 'approximately', respectively, are used herein to mean approximately, near, approximately or within an area. When the terms 'about' or 'approximately' are used in conjunction with a numerical value or range, it modifies that value or range by reasonably extending the boundaries above and below the stated numerical value.

An "alkaloid" is a group of nitrogenous compounds, usually of plant origin. For example, nicotine is a primary alkaloid found in commercialized conventional cigarette tobacco and, depending on the tobacco type (e.g., yellow, burley, and oriental) and variety (e.g., K326), is present in tobacco leaves. It accounts for about 95% of the total alkaloids. Anatabine, nornicotine, anabasine and other alkaloids make up the remainder of the total alkaloids. The alkaloid profile, which is the percentage or contribution of each alkaloid to the total content of all alkaloids, differs according to cigarette type, tobacco variety and cigarette brand filler. Depending on tobacco type and variety, anatabine accounts for about 1% to about 4%, nornicotine for about 1% to about 3%, and anavacin for about 0.02% to about 0.4%. As used herein, 'nicotine', 'anatabine' and 'anavacin' may be extracted from any plant species, including any species of the genus Nicotiana , and any of these alkaloids may be synthesized. It can also be prepared in the form of salts of organic acids, analogs, or organic acids. See, for example, Sisson et al., 1990, Beitragezur Tabakforschung International, Vol. 14, No. 6, June-July. synthetic nicotine, nicotine salts derived from synthetic nicotine, synthetic anatabine, anatabine salts derived from synthetic anatabine, synthetic anabacin, anabasin salts derived from synthetic anabacin, analogues of nicotine, analogues of anatabine, anabacin Analogs, nicotine salts of organic acids, anatabine salts of organic acids and anabasin salts of organic acids are included herein with the meanings of nicotine, anatabine and anabasin, respectively. Nicotine salts, nicotine co-crystals, and nicotine salt co-crystals are all included within the meaning of nicotine herein, and any of these, including combinations, may be used in any of the examples herein.

Nicotine can be used in that form in the examples herein as a hygroscopic oily liquid, but compared to the liquid form of nicotine, the end user may prefer a solid or semi-solid due to the increased stability and cleaner and easier application for the end user. It is desirable for embodiments herein to enhance the delivery of nicotine in a final tobacco product having nicotine as the For example, we disclose nicotine salts, nicotine co-crystals and nicotine salt co-crystals in solid or semi-solid form, but methods or devices for consumers to incorporate nicotine as an auxiliary nicotine source into finished tobacco products or smoking products such as factory manufactured cigarettes. See U.S. Patent No. 9,738,622, which does not disclose . Liquid forms of nicotine such as e-liquid or e-juice will inhibit ignition and combustion of smoking products to produce smoke, and the nicotine content is too dilute to be a significant and effective secondary nicotine source. Besides being too bulky for the examples herein, these liquid and diluted forms of nicotine require too much aerosol to be generated for a given amount of nicotine, so the vaporizers of some aerosol examples herein will defeat the purpose. Regardless of smoke or vapor, the less inhaled the better, which is an advantage of concentrating nicotine and cannabinoids in the examples herein.

In addition to solid or semi-solid forms of nicotine, other compounds used in the formulations herein for onserts, precision rods, and precision pods are preferably in solid or semi-solid forms. Of course, solids are fundamental and are commonly referred to as states of matter (others being liquid, gas and plasma). Semi-solid is a physical term for something whose state is between a solid and a liquid. Semi-solid materials are similar to solids in some characteristics, such as their ability to support their own weight and retain their own shape. Examples of semi-solids include peanut butter, toothpaste and petrolatum. The formulation of compounds and ingredients for formulation in, on or within an onsert, precision rod or precision pod may include solids, semi-solids and liquids, but the final formulated formulation is preferably a solid or semi-solid (e-liquid). and not liquid). For example, the blend of ingredients within the compartments of the precision pod can include a crystalline nicotine salt, concentrated hemp wax, and liquid glycerin, such that the final formulated formulation is even if a liquid is used (with the appropriate level of moisture added). to be) solid or semi-solid (depending on the respective proportions of the three components used).

A nicotine salt is a form of nicotine characterized by an interaction between nicotine in ionic form and a coformer, such as an acid, in ionic form by transferring one or more protons from a coformer donor to a nicotine acceptor. Since the structure of nicotine has two nitrogen atoms that can accept protons from the coformer, it can exist in non-protonated, single-protonated or double-protonated forms. Examples of nicotine salts include, but are not limited to: nicotine 4-acetamidobenzoate, nicotine ascorbate, nicotine aspartate, nicotine benzoate, nicotine bitartrate, nicotine chlorides such as nicotine dihydrochloride and nicotine hydrochloride. , nicotine citrate, nicotine 2,3-dihydroxybenzoate, nicotine 3,5-dihydroxybenzoate, nicotine fumarate, nicotine gentisate (2,5-hydroxybenzoic acid), nicotine glutamate, nicotine l -Hydroxy-2-naphthoate, nicotine 3-hydroxybenzoate, nicotine lactic acid, nicotine levulin, nicotine malate, nicotine mono-pyruvate, nicotine mucate, nicotine perchlorate, nicotine pyruvate, nicotine salicyl Late, nicotine succinate, nicotine sulfate, nicotine tartrate and nicotine zinc chloride.

A nicotine co-crystal is a form of nicotine comprising nicotine and at least one other component (coformer), both in neutral form. Co-crystals are generally characterized by a crystalline structure, which is generally held together by freely reversible non-covalent interactions. Co-crystals consist of nicotine and at least one other component in conventionally defined stoichiometric ratios, and may include hydrates, solvates and clathrates. Co-crystals may contain nicotine in combination with organic and/or inorganic components and are generally distinguished from salts by the absence of proton transfer between the components (nicotine and one or more co-formers) in the co-crystal. In contrast, nicotine salt co-crystals are a type of hybrid structure that has both salt and co-crystal features. Generally, a nicotine molecule in a salt co-crystal is associated with at least two co-forms (which may be the same or different), wherein one co-form is in the form of an ion, such as an acid, transfers a proton to the nicotine molecule, and the second co-form is does not transfer a proton to the nicotine molecule. Nicotine in any form, including nicotine salts, nicotine co-crystals, and/or nicotine salt co-crystals, may be used herein for any of the onsert, precision rod, or precision pod embodiments.

As used herein, “cigarette” means any tobacco roll that may contain non-tobacco material, is wrapped in paper, and burns to produce smoke when lit. Cigarettes generally also include a filter, plug wrap (containing the filtration material) and tipping paper (which secures the cigarette paper to the filter and plug wrap). The glue seals the cigarette paper together, and if the cigarette has a filter, the glue holds these other components together. The term cigarette also includes any roll of tobacco wrapped in any material containing tobacco, which, by virtue of its appearance, the type of tobacco used, or its packaging and labeling, is offered to or purchased by a consumer as a cigarette. There is a possibility. One example is the 'small cigar', which may contain a filter and generally looks very similar to a cigarette. Factory cigarettes refer to cigarettes that are manufactured and rolled in a factory by a cigarette manufacturer, and are generally purchased at retail by the end user, unless offered to smokers as study cigarettes. Factory-manufactured cigarettes are generally supplied in packs of 20 cigarettes. As used herein, "marijuana cigarette" means any roll of hemp wrapped in paper or any other non-tobacco material, which when lit produces smoke for inhalation. Marijuana cigarettes (ie, joints) do not contain tobacco; As disclosed herein, when an onsert or precision rod is attached to or inserted into a marijuana cigarette, it may produce nicotine or other tobacco alkaloids. Marijuana cigarettes can be rolled by hemp end users or manufactured in factories by hemp manufacturers. Unlike a marijuana cigarette, a blunt is marijuana made by wrapping tobacco in a tobacco leaf or cigar wrapper, and a spliff is a marijuana cigarette that also contains tobacco.

Unlike factory-manufactured cigarettes, roll-your-own (RYO) or make-your-own (MYO) cigarettes are made by the end user of the cigarette. RYO cigarettes are made from tobacco and rolling paper. Cigarettes can also be rolled into rolling paper using a tobacco roller. MYO cigarettes are generally made with mechanical MYO machines that insert cigarettes and tobacco into empty cigarette tubes (with or without filters). The mechanism inserts the cigarette into the tube, resulting in a cigarette that looks very similar to factory-roll cigarettes purchased at a regular store. Tobacco and Rolling Paper (RYO) or Tobacco and Tube (MYO) cigarettes are generally cheaper for consumers to purchase, respectively, than factory-manufactured cigarettes, but RYO and MYO cigarettes are time-consuming and tedious to assemble and are usually factory-manufactured. It does not have the uniformity or quality of cigarettes. RYO cigarettes and MYO cigarettes are essentially the same and are very similar to the fillers in factory manufactured cigarettes. RYO cigarettes, MYO cigarettes and pipe tobacco are all end tobacco products (as defined below) purchased for smoking by end users of tobacco.

As used herein, a "filler" is wrapped around the rod of a cigarette, or tobacco stick of a tobacco heating device (or to a tobacco heating rod [eg, TEEPS®] if the tobacco heating product does not have a separate holder). (in addition to cigarette paper) selected from the group consisting of cut tobacco leaves (cut-rag), tobacco stems, reconstituted tobacco, puffed tobacco, hemp, casings, flavorings and other additives or ingredients such as cannabinoids or additional alkaloids. ) means cumulative smokeable substances. Reconstituted tobacco is generally included in the filler of factory-manufactured cigarettes and is similar to cut rag tobacco. Puffed tobacco is also commonly included in the filler of factory-manufactured cigarettes and is treated through the expansion of suitable gases to reduce the density of the tobacco rod and increase the filling capacity when the tobacco is 'puffed'. Puffed tobacco reduces the weight of the tobacco used in cigarettes.

As used herein, "reconstituted tobacco", also known as Recon, means a tobacco sheet produced by rolling or casting pre-finely ground tobacco dust, stems and/or by-products and then mixing with a coagulant or binder; , generally contain wetting agents, flavoring agents, and preservatives. This results in a paper-like malleable sheet that is essentially reconstituted tobacco. Two types of reconstituted cigarettes known in the art are band cast and paper cast. For each of these, every producer has a slightly different process. The Recon process allows the addition of virtually any compound or plant fraction. Once the reconstituted tobacco sheets are produced, they are cut into small strips. The size and shape of the strip is generally similar to that of cut-rag tobacco, and reconstituted tobacco can be formulated into the filler of a cigarette; Large Recon sheets can be cut to any size. See, eg, US Pat. Nos. 4,270,552 and 5,724,998 and Chapter 11, 377-379, Tobacco: Production, Chemistry and Technology, 1999. Nicotine, anatabine, anabasin, THCA, CBDA, CBCA, CBGA, THCVA, CBDVA, CBCVA, CBGVA, myrcene, caryophyllene, pinene, limonene and/or humulene are additionally added during the Recon production process before the sheet is made. can be integrated In some exemplary embodiments herein, a reconstituted tobacco sheet is used in the manufacture of a wrapper for an onsert, the reconstituted sheet may be thus cut, or the reconstituted tobacco sheet may be very finely cut and ground and incorporated into a precision pod or precision rod. there is. In another exemplary embodiment, an ultra low nicotine cigarette is reconstituted and used for an onsert, precision rod or precision pod.

As used herein, “reconstituted hemp” refers to cannabis flowers, leaves, flour, stems, and/or previously finely ground by-products which are then rolled or cast and generally mixed with a coagulant or means a hemp sheet produced in the same manner as a reconstituted tobacco sheet mixing with a binder. The reconstituted hemp sheet does not need to contain any tobacco parts, so it can be made without tobacco, or without nicotine if nicotine is not required, and can be easily made into a reconstituted sheet similar to reconstituted cigarettes. The hemp portion of the reconstituted hemp sheet can be made from approximately 70% to approximately 90% cannabis plant parts. Once manufactured, the reconstituted hemp sheet is cut to any desired size. In some exemplary embodiments, reconstituted hemp is used in the manufacture of wrappers for onserts or is cut very finely and incorporated into precision pods or precision rods. Nicotine, anatabine, anabasin, THCA, CBDA, CBCA, CBGA, THCVA, CBDVA, CBCVA, CBGVA, myrcene, caryophyllene, pinene, limonene and/or humulene are added during the reconstituted production process before the reconstituted hemp sheet is fabricated. can be further integrated. Ultra low THC hemp or THC-free hemp can be produced from hemp lines or strains, or lines or strains of cannabis that have been genetically engineered for ultra-low THC content and used for reconstituted hemp. Both ultra low THC hemp and low nicotine (or zero nicotine) cigarettes can be used in the same reconstituted sheet.

In another exemplary embodiment, reconstituted plant material (eg, leaves and stems) is utilized for production of wrappers for onserts or for use in precision pods or precision rods, and the reconstituted sheet does not contain any tobacco or hemp. For example, herbs such as jasmine and ginseng are used in the production of "reconstituted herbal sheets". Whether reconstituted tobacco, reconstituted hemp and/or reconstituted jasmine, for example nicotine, anatabine, anabasin, THCA, CBDA, CBCA, CBGA, THCVA, CBDVA, CBCVA, CBGVA, myrcene, caryophyllene, pinene, limonene and/or humulen is incorporated (injected) during the Recon production process before the reconstituted sheet is manufactured.

As used herein, “finished tobacco product” means a tobacco product prepared for consumer use or consumption, including cigarettes, cigars, cigars, cigarillos, and roll-your-own (RYO) tobacco (which the end user owns Do-It-Yourself (MYO) cigarettes (generally used by end users, with cigarette tubes and mechanical MYO machines, to make their own cigarettes or marijuana cigarettes) is inserted into an empty cigarette tube by the machine), hemp, pipe tobacco, tobacco heating products (e.g., IQOS®), snuff, snus, and chewing tobacco such as dipping tobacco. But not limited to this. E-cigarettes are not tobacco products because the only fraction of tobacco they contain is nicotine. RYO cigarettes or MYO cigarettes may not be designated as either on the packaging and may be referred to as "cigarettes" because they may be used as RYO cigarettes or MYO cigarettes.

As used herein, a “smoking product” means, when used by itself (e.g., a cigarette) or interdependent smoking product (e.g., a pipe and pipe tobacco are interdependent), upon ignition, inhalation. producing mainstream smoke for (smoke from certain cigars may not be inhaled by some cigar smokers, nicotine is absorbed through the mouth due to the high nicotine content and high pH of the smoke), consumer use or any prepared for consumption means a product, cigarette, cigar, roll-your-own (RYO) tobacco, hemp, RYO tobacco or rolling paper for hemp, make-your-own (MYO) tobacco, MYO tobacco or hemp tobacco tube, pipe, bowl, rod, tobacco , reconstituted cigarettes, splips, blunts, and marijuana cigarettes. Individually or collectively, RYO cigarettes and MYO cigarettes may be referred to herein as 'cigarettes' or 'finished cigarettes'. A bowl is a type of pipe that usually has a shorter stem. A 'tobacco chamber', 'hemp chamber' or 'chamber' is a place where tobacco or hemp is burned in pipes, bowls and bongs. Onserts, precision rods and certain precision pods (not for vaporizers) are also smoking products.

As used herein, "conventional cigarette" means a cigarette having a conventional nicotine content of at least 9 mg per cigarette. The average nicotine content of conventional commercial cigarette brands is approximately 14 mg nicotine per cigarette, but may range from approximately 9 mg to greater than 20 mg nicotine per cigarette. Morton et al., 2008, Regul Toxicol Pharmacol . See doi: 10.1016/j.yrtph.2008.03.001.

As used herein, "ultra low nicotine cigarettes" contain less than 2.0 milligrams (mg) of nicotine per cigarette, such as 0.05 mg, 0.10 mg, 0.15 mg, 0.20 mg, 0.25 mg, 0.30 mg, 0.35 mg per cigarette. , 0.40 mg, 0.45 mg, 0.50 mg, 0.55 mg, 0.60 mg, 0.65 mg, 0.70 mg, 0.75 mg, 0.80 mg, 0.85 mg, 0.90 mg, 0.95 mg, 1.00 mg, 1.05 mg, 1.10 mg, 1.15 mg, 1.20 Contains less than 1.85 mg, 1.90 mg, or 1.95 mg of nicotine cigarettes that The nicotine content per cigarette is calculated by multiplying the nicotine content of the filler in the cigarette rod by the weight of the filler in the cigarette rod. For example, if the weight of the cigarette filler is 0.666 grams and the nicotine content is 3 mg/g, the cigarette has a nicotine content of about 2 mg. A filler with a nicotine content of 3 mg/g corresponds to approximately 85% of the average nicotine content of cigarette fillers of existing cigarette brands at about 20 mg/g.

Ultra low nicotine cigarettes have been manufactured by the tobacco industry at various points over several decades. For example, the John Alden Tobacco Company manufactured John Alden 's ultra-low nicotine cigarette brand in the 1950s, which "contains at least 85% less nicotine than the two leading filter tip brands". tip brands)" and advertised the brand. The low nicotine cigarettes used in John Alden 's Ultra Low Nicotine Cigarettes have been classified as Type 31-V by the USDA. In addition to growing tobacco that already has ultra-low nicotine, other processes have been developed. For example, Philip Morris USA has developed a commercial supercritical CO2 process that removes 97% of the nicotine from the filler and marketed several brands of ultra-low nicotine cigarettes.

As used herein, "nicotine-enhanced cigarette" refers to an industry-recognized standardized smoking machine test method (e.g., For example, a cigarette has a nicotine smoke yield greater than 7% as measured by International Standards Organization [ISO] Smoking-Machine Test Method 4387:2000 [Cigarettes - Determination of Total and Nicotine Free Particulate Matter Using Conventional Analytical Smoking Machine]) means a cigarette that includes a supplemental nicotine source (eg, from an onsert or precision pod) that causes it to increase. The nicotine yield of ultra low nicotine cigarettes or conventional cigarettes can be enhanced by a secondary nicotine source. Other examples of industry accepted and standardized smoking machine test methods are the Canadian intense method, the Massachusetts method, and the Federal Trade Commission (FTC) method. In addition to a supplemental nicotine source, nicotine-enhanced cigarettes may also utilize a device used with a supplemental nicotine source, such as a cigarette holder.

Depending on the design of the cigarette into which the supplemental nicotine source is injected, including the level of ventilation of the cigarette, the increase in nicotine smoke yield will vary with the cigarette type for a given amount of supplemental nicotine (e.g., a precision rod containing 10 mg of nicotine). Each will be different. As small amounts of nicotine in cigarette fillers (average nicotine content of cigarettes is about 14 mg) are transferred into mainstream smoke (which can be measured by smokers), this is virtually negligible at about 1% nicotine content in highly ventilated cigarettes. In non-ventilated cigarettes, up to about 10% nicotine content, similarly small amounts of nicotine are transferred from the onsert or precision rod into the mainstream smoke. This nicotine delivery rate, which is the rate at which the nicotine content in the cigarette filler (and/or the nicotine content in the nicotine onsert) is delivered to the mainstream smoke as measured by a smoking machine, also depends on the cigarette paper and/or the secondary nicotine source (e.g. For example, onsert) whether or not (or at what level) combustion promoters or ash reformers are included. The manner in which a smoking product comprising a cigarette is smoked (ie, strongly, loudly and frequently, or not) also affects the rate of nicotine delivery of the cigarette, with or without a secondary nicotine source. Certain smoking regimes, such as the ISO, Canadian intense method, or Massachusetts method standardize nicotine yield with or without onsert or precision rod, respectively.

The increased nicotine yield of the smoke of the nicotine-enhanced cigarette can be, for example, at least 0.002 mg, 0.003 mg, 0.004 mg, 0.005 mg, 0.006 mg, 0.007 mg, 0.008 mg, 0.009 mg, 0.010 mg, 0.011 mg, 0.012 mg, 0.013 mg, 0.014 mg, 0.015 mg, 0.016 mg, 0.017 mg, 0.018 mg, 0.019 mg, 0.020 mg, 0.025 mg, 0.030 mg, 0.035 mg, 0.040 mg, 0.045 mg, 0.050 mg, 0.055 mg 0.060 mg, 0.065 mg, 0.070 mg, 0.075 mg, 0.080 mg, 0.085 mg, 0.090 mg, 0.095 mg, 0.100 mg, 0.125 mg, 0.150 mg, 0.175 mg, 0.200 mg, 0.225 mg, 0.250 mg, 0.0.275 mg , 0.325 mg, 0.350 mg, 0.375 mg, 0.400 mg, 0.425 mg, 0.450 mg, 0.475 mg, 0.500 mg, 0.525 mg, 0.550 mg, 0.575 mg, 0.600 mg, 0.625 mg, 0.650 mg, 0.675 mg, 0.75 mg, 5 mg, 0.750 mg, 0.775 mg, 0.800 mg, 0.825 mg, 0.850 mg, 0.875 mg, 0.900 mg, 0.925 mg, 0.950 mg, 0.975 mg or 1.000 mg nicotine and the like. For example, the nicotine-enhanced cigarette may be an ultra-low nicotine cigarette with an increased nicotine yield from 0.03 mg to 0.05 mg.

As used herein, “anatabine-fortified cigarette” means a cigarette comprising a source of supplemental anatabine, and thus when measured by a test method capable of quantifying anatabine in smoke, and Produces a cigarette with an increased anatabine yield of at least 7% as measured by the same test method compared to a factory manufactured cigarette of the same type without the tarbine source. For an example of such a test method, see Zhang et al., 2018, Rapid Commun Mass Spectrom ., 32:1791-1798 (DOI: 10.1002/rcm.8222). The anatabine yield of ultra low nicotine cigarettes or conventional cigarettes can be enhanced by a secondary anatabine source, for example from an onsert or precision rod.

Such anatabine sources may be plants, including tobacco plants, which are rich in anatabin, which is extracted, for example, by a supercritical CO ₂ extraction process. The anatabine content may be enhanced by anatabine salts of organic acids, anatabine analogs or synthesized anatabine. The increased anatabine yield of smoke of an anatabine fortified cigarette can be, for example, at least 0.10 μg, 0.15 μg, 0.20 μg, 0.25 μg, 0.30 μg, 0.35 μg, 0.40 μg, 0.45 μg, 0.50 μg. , 0.55 μg, 0.60 μg, 0.65 μg, 0.70 μg, 0.75 μg, 0.80 μg, 0.85 μg, 0.90 μg, 0.95 μg, 1.00 μg, 1.10 μg, 1.20 μg, 1.30 μg, 1.40 μg, 1.50 μg, 1.1.60 μg, 1.60 μg, μg, 1.80 μg, 1.90 μg, 2.0 μg, 2.25 μg, 2.50 μg, 2.75 μg, 3.0 μg, 3.25 μg, 3.50 μg, 3.75 μg, 4.0 μg, 4.25 μg, 4.50 μg, 4.75 μg, 5.0 μg, 5.25 μg, 5.50 μg, 5.75 μg, 6.0 μg, 6.25 μg, 6.50 μg, 6.75 μg, 7.0 μg, 7.25 μg, 7.50 μg, 7.75 μg, 8.0 μg, 8.25 μg, 8.50 μg, 8.75 μg, 9.0 μg, 9.25 μg, 9.25 μg, 9.25 μg , 9.75 μg, 10 μg, 11 μg, 12 μg, 13 μg, 14 μg, 15 μg, 16 μg, 17 μg, 18 μg, 19 μg, 20 μg, 21 μg, 22 μg, 23 μg, 24 μg, 25 Equivalent to μg, 30 μg, 35 μg, 40 μg, 45 μg or 50 μg of anatabine per cigarette. An advantage of anatabine fortified ultra-low nicotine cigarettes is that these types of cigarettes reduce withdrawal and craving of conventional cigarettes more effectively than ultra-low nicotine cigarettes without anatabine fortification. Anatarbine-enhanced ultra-low nicotine cigarettes are particularly useful when used to assist a smoker transition to an e-cigarette or tobacco heating device or to assist a smoker to quit tobacco and nicotine use entirely.

As used herein, “anabacin-fortified cigarette” means a cigarette comprising a source of adjuvant anabacin, and thus when measured by a test method capable of quantifying anabacin in smoke, and the adjuvant anabacin Produces a cigarette with an increased anabasin yield of at least 7% as measured by the same test method compared to a factory manufactured cigarette of the same type without sauce. For an example of such a test method, see Zhang et al., 2018, Rapid Commun Mass Spectrom ., 32:1791-1798 (DOI: 10.1002/rcm.8222). The anabasin yield of ultra low nicotine cigarettes or conventional cigarettes can be enhanced by a secondary anabacin source, for example from onsert or precision rods.

Such anabacin sources include tobacco plants or plants where the predominant alkaloid is anabacin, such as Nicotiana glauca , Nicotiana noctiflora , Nicotiana petunioides and/or Nicotiana dev It may be a Nicotiana debneyi plant. Anabasin can be extracted from any type of tobacco, for example by a supercritical CO2 extraction process. The anabacin content may be enhanced by anabacin salts of organic acids, anabacin analogs or synthetic anabacin. The increased anabasin yield of an anabasin-enhanced cigarette can be, for example, at least: 0.01 μg, 0.02 μg, 0.03 μg, 0.04 μg, 0.05 μg, 0.06 μg, 0.07 μg, 0.08 μg, 0.09 μg, 0.10 μg, 0.15 μg, 0.20 μg, 0.25 μg, 0.30 μg, 0.35 μg, 0.40 μg, 0.45 μg, 0.50 μg, 0.55 μg, 0.60 μg, 0.65 μg, 0.70 μg, 0.75 μg, 0.80 μg, 0.85 μg, 0.85 μg , 0.95 μg, 1.00 μg, 1.10 μg, 1.20 μg, 1.30 μg, 1.40 μg, 1.50 μg, 1.60 μg, 1.70 μg, 1.80 μg, 1.90 μg, 2.0 μg, 2.25 μg, 2.50 μg, 2.75 μg, 3.0 μg μg, 3.50 μg, 3.75 μg, 4.0 μg, 4.25 μg, 4.50 μg, 4.75 μg, 5.0 μg, 5.25 μg, 5.50 μg, 5.75 μg, 6.0 μg, 6.25 μg, 6.50 μg, 6.75 μg, 7.0 μg, 7.25 μg, 7.50 μg, 7.75 μg, 8.0 μg, 8.25 μg, 8.50 μg, 8.75 μg, 9.0 μg, 9.25 μg, 9.50 μg, 9.75 μg, 10 μg, 11 μg, 12 μg, 13 μg, 14 μg, 15 μg, 16 μg , 17 μg, 18 μg, 19 μg, 20 μg, 21 μg, 22 μg, 23 μg, 24 μg, 25 μg, 26 μg, 27 μg, 28 μg, 29 μg, or 30 μg of anavacin per cigarette. . An advantage of anabasin fortified ultra-low nicotine cigarettes is that these types of cigarettes reduce withdrawal and craving of conventional cigarettes more effectively than ultra-low nicotine cigarettes without fortified anabacin. Anabasin-enhanced ultra-low nicotine cigarettes are particularly useful when used to assist a smoker transition to an e-cigarette or tobacco heating device, or to assist a smoker to quit tobacco and nicotine use entirely.

The total alkaloid level or the level of individual alkaloids, such as nicotine, anatabine or anabasin, in a cigarette or filler can be measured by a number of methods known in the art. Examples are quantification based on gas chromatography (GC) and high performance liquid chromatography. See, for example, Lisko et al., 2013, Anal Chem . March 19; 85(6): 3380-3384, which provides the following methods for determining the amount of alkaloids in fillers by cigarette brand and cigarette type (e.g. Burley). Analysis of minor alkaloids, such as anatabine or anabacin, is performed using gas chromatography (GC) coupled with a wide range of detection techniques including flame ionization detection (FID), nitrogen-phosphorus detection (NPD), and mass spectrometry (MS). has been carried out Other analytical approaches include high-performance liquid chromatography-ultraviolet detection (HPLC-UV), capillary zone electrophoresis-ultraviolet detection (CZE-UV), micellar electrodynamic capillary chromatography-ultraviolet detection (MECC-UV), nitrogen chemiluminescence detection ( NCD), and microemulsion electrodynamic chromatography-ultraviolet detection (MEEKC-UV). Gas chromatography-tandem mass spectrometry (GC-MS/MS) in multiple reaction mode (MRM) mode removes matrix ions arising from other compounds that share the same parent mass but lack precise transition ions; It can dramatically reduce background interference and allow greater compound specificity by reducing detection limits. The amount of nicotine (and propylene glycol and glycerol) in an e-liquid or formulation in a precision rod or precision pod can be determined by ISO/DIS 20714, a gas chromatography method, or any other method known in the art. . Unless otherwise specified or implied, analyte measurements (eg nicotine) are made on a dry weight basis.

For any illustrative embodiment herein, nicotine is known in the art for extracting nicotine, anatabine and anabasin from a Nicotiana plant, such as a N. rustica plant, and then purifying the extract. It is provided first by any one of a variety of methods known to. These methods are utilized in nicotine replacement therapy products such as nicotine lozenges and nicotine patches. Alternatively, in another embodiment, synthetic nicotine, synthetic anatabine or synthetic anabasin is provided first, which provides the advantage of not being extracted from tobacco. See, for example, US Pat. No. 9,556,142 and Ayers et al., 2005 The AAPS Journal ; 7(3) Article 75, E752-E758 (http://www.aapsj.org). The nicotine is then prepared, preferably in solid or semi-solid form, by any of the methods known in the art. They may be in crystalline and/or amorphous form.

Upon crystallization or solidification, the nicotine salt may be cut or ground to form any shape or size depending on the application. For nicotine powder applications, the size can be as small as 25 μm, and for other applications, the size can be 5 mm. Alternatively, nicotine salts are commercially available. For example, nicotine bitartrate dehydrate, in powder form, a pure water-soluble crystalline salt of nicotine used in the production of nicotine candies and gums, is available from Alchem International SA.

ELECTRONIC NICOTINE DELIVERY SYSTEMS (ENDS)

Many types of ENDS have been developed and marketed in the past decade. For example, a tobacco heating product consists of a holder, a tobacco stick and a charger. For example, an IQOS® cigarette stick (HeatStick®) is inserted into an IQOS® holder that heats the tobacco material by electronically controlled heating blades. HeatStick® differs from cigarettes in several ways. For example, cigarettes in HeatSticks® for IQOS® products are made from unburnt tobacco powder, which is uniquely processed and specially designed to function with the holder to create an aerosol. In another exemplary configuration, the tobacco heating device is ignited like a conventional cigarette. There may be no holder, charger or battery, and the cigarette may be heated directly on the cigarette heating rod. For example, a ignited carbon heat source heats (but does not burn) a cigarette, creating an aerosol similar to a cigarette heating device comprising a separate cigarette stick. A type of tobacco heating device with a carbon heat source, for example, is physically very similar to a conventional cigarette, but does not burn. A disposable heating element is contained within each rod that creates an aerosol that is inhaled and is known herein as a “tobacco heating rod” or “heating rod”. One example is TEEPS® being developed by Philip Morris International. Other examples include Eclipse® and Revo®, which were previously sold in the US but are no longer sold. In another configuration, the tobacco heating device does not have a holder or charger, and includes a battery within every heating rod, and each heating rod may be disposable. Accordingly, it is understood that any device that generates an aerosol by heating tobacco (or tobacco in a form such as tobacco extract or reconstituted tobacco) to a temperature lower than combustion (without burning the tobacco) is a tobacco heating device, and the holder or It does not matter whether there is a separate cigarette stick from the heating element, whether or not a battery needs charging or even a battery, whether some part needs to be ignited, such as the end of a carbon heat source, and/or whether any electronics are included. don't As used herein, the terms tobacco heating device, tobacco heating product, non-combustion-heated tobacco device, and non-combustion-heated tobacco product are synonymous.

An e-cigarette is a rechargeable device containing a heating coil and an atomizer (also called e-juice) that converts e-liquid into an aerosol, a cartridge containing e-liquid, etc. (stick or pod), mouthpiece , and batteries for rechargeable devices. There are many looks and designs that can involve various steps, but they generally work by drawing on the e-cigarette, activating a heating element that aerosolizes the e-liquid, and inhaling the aerosol. E-liquids usually contain nicotine, water, flavoring agents and humectants. The humectant acts as a carrier solvent that dissolves and aerosolizes the nicotine and flavoring agent at a specific temperature on the atomizer of the e-cigarette. Typically, propylene glycol and/or glycerol are the solvents used for e-liquids. For example, the e-liquid of an e-cigarette contained in a cartridge has a nicotine content that varies greatly depending on brand and brand style.

A vaporizer (vape) vaporizes plant material, typically hemp, for inhalation without burning the material. These include both dry herbal vaporizers (eg for hemp flowers) and vaporizers configured for plant extracts such as concentrates or wax extracts. Some vaporizers are configured for both dry herbs and concentrated extracts such as PAX 3®. Vaporizers configured for dry herbs and/or concentrates are usually open systems, allowing the user to place whatever they desire into the oven chamber and then the oven chamber is closed with a cover or the like. This type of open system vaporizer, such as the PAX 2®, is distinct from closed system vaporizers such as the glo® and IQOS®, which use a cigarette stick and do not have access to a cigarette; Open system vaporizers work similarly to glo® and IQOS®, in that open systems likewise produce vapor from smokeable plant material (e.g., hemp), which typically has a moisture level of about 10% to about 17%. because it makes The ready-to-vappable precision pods disclosed herein can work with dry herb vaporizers and vaporizers for beneficial concentrates. Open system vaporizers also differ from e-cigarettes in that e-cigarettes use e-liquid and open system vaporizers do not. Compared to the exemplary embodiments herein of ready-to-vape precision pods containing nicotine in concentrated form, the e-cigarette provides an approximately 0.7 ml or less amount of nicotine in the e-liquid, typically equal to 5% nicotine by weight. Because it dilutes dramatically in concentration, it allows the user to inhale a much larger amount of vapor for a satisfactory amount of nicotine (eg, 1 mg). Some other vaping devices deliver e-liquids at higher concentrations, but none come close to the concentration of nicotine in a formulation of ready-to-vape tobacco precision pods, including, for example, crystalline cannabinoids and crystalline nicotine salts.

The vaporizer includes a temperature controller, an oven or vaporization chamber (where the substance to be heated is placed), a cover for the oven chamber, a mouthpiece, a sensor and an electronic heater with a rechargeable battery. In general, compared to burning cannabis from smoking products, extraction of cannabinoids occurs significantly more in vaporizers that heat cannabis due to lack of combustion. The typical temperature of the vaporizer in the oven chamber ranges from about 160°C to about 230°C and produces vapor for inhalation; The range may be wider (eg 100 °C to 265 °C) as higher temperatures are required for the concentrate. Main stream vapors are vapors that are inhaled and include vapors that come from a person's mouth using a vaporizer or from the mouth end of a vaporizer.

Hemp and Hemp Formulations

As used herein, "Cannabis" includes Cannabis sativa, Cannabis indica and Cannabis ruderalis . Both marijuana and hemp strains or cultivars are hemp. Hemp is genetically more similar to the indica type of marijuana than to the sativa strain. Cannabinoids are a group of over 100 natural chemical compounds that accumulate primarily in the female flowers (also known as buds) of the cannabis plant. They act on intracellular cannabis receptors that alter the release of neurotransmitters in the brain. THCA/THC is one of dozens of cannabinoids present in the cannabis plant. Cannabinoids can be endogenously produced by genetically engineered tobacco plants for use as onserts, precision rods, and precision pods, produced synthetically (see, eg, U.S. Patent No. 9,587,212), or extracted from the cannabis plant. there is. When a smoker quits conventional cigarettes, levels of anxiety and depression generally increase; Thus, an ultra low nicotine cigarette combined with an onsert or precision rod containing very minute amounts of crystalline CBDA is beneficial to help smokers transition to e-cigarettes or tobacco heating devices or quit tobacco and nicotine use altogether. For these applications, smoke from ultra-low nicotine cigarettes that also contain non-THC cannabinoids, either onsert or precision rods, is improved over smoke from ultra-low nicotine cigarettes without cannabinoids. As disclosed in U.S. Patent Application No. 16/047,948, the longer the smoker can exclusively smoke an ultra-low nicotine cigarette (without smoking any conventional cigarettes) during the transition period, either convert to an e-cigarette or tobacco heating product, or You are more likely to quit smoking and nicotine use completely.

The psychoactive effects of THC are primarily mediated by activation of cannabinoid receptors distributed throughout the body, which are part of the endocannabinoid system involved in various physiological processes such as mood and appetite. With hemp strains (with significant THCA content) or marijuana strains or varieties, inclusion in ultra-low nicotine cigarettes to help smokers transition to e-cigarettes or tobacco heating devices is problematic, as the psychoactive effects of THC This is because it will interfere with the daily life of smokers in that it will reduce their physical and mental control. For example, a smoker attempting to switch to an e-cigarette or cigarette heating device will not be able to smoke an ultra-low nicotine cigarette containing significant levels of THCA during a lunch break while at work, thus not functioning normally when returning to work. may not be able to do so, which could be dangerous to co-workers. Additionally, staff may fail drug tests if their ultra-low nicotine cigarettes contain hemp containing THCA. Thus, inclusion of crystalline CBDA (and not hemp) from an onsert or precision rod with an ultra low nicotine cigarette or conventional cigarette, or from a precision pod with a vaporizer prevents any psychoactive effects of THC while retaining the benefits of CBD. It is useful and advantageous to do Crystalline CBDA, which is 99.5% pure, does not have any intoxicating effects of THC.

9-테트라하이드로카나비놀산), CBDA(카나비디올산), CBCA(카나비크로멘산), CBGVA(카나비게로바린산), THCVA(테트라하이드로카나비바린산), CBDVA(카나비디바린산) 및 CBCVA(카나비크로메바린산)의 각각은 하기 8가지 카나비노이드 화합물로 변환되어, 이를 수득할 수 있게 한다: CBG(카나비게롤), THC(

9-테트라하이드로카나비놀), CBD(카나비디올), CBC(카나비크로멘), CBGV(카나비게리바린), THCV(테트라하이드로카나비바린), CBDV(카나비디바린) 및 CBCV(카나비크로메바린). 대마가 경화되어 수분이 감소함에 따라, 산성 형태의 카나비노이드 화합물이 성숙하여 관련 화합물로 (예를 들어, THCA에서 THC로) 서서히 변환된다. 대마를 경화시키고 시간이 지남에 따라 보관하면 부분적인 탈카르복실화만이 발생하는데, 대마 꽃이 검사에서, 예를 들어 THCA 및 THC (본원에서 THCA/THC로 표시됨) 둘 다에 대해 대부분 양성인 이유가 이 때문이다. 대마를 흡연하거나 기화시키면, 고온의 존재로 인해 카나비노이드를 산성 형태(예: THCA에서 THC로)로 탈카르복실화하여, 이를 흡입을 통해 즉시 흡수될 수 있게 한다.To understand the cannabinoid biosynthetic pathway in Cannabis sativa . Cannabigerolic acid (CBGA) is the precursor to the three major cannabinoid families: tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA) and cannabichromenic acid (CBCA). During decarboxylation, which occurs during drying and drying of plant material and/or when heat is applied to the cannabinoid acids (e.g., when smoking), the following eight cannabinoid acids: cannabigerolic acid (CBGA), THCA (

9-tetrahydrocannabinolic acid), CBDA (cannabidiolic acid), CBCA (cannabichromenic acid), CBGVA (cannabigerovaric acid), THCVA (tetrahydrocannabivaric acid), CBDVA (cannabidivaric acid) and CBCVA Each of (cannabichromevarin acid) is converted into the following 8 cannabinoid compounds, making it possible to obtain them: CBG (cannabigerol), THC (

9-tetrahydrocannabinol), CBD (cannabidiol), CBC (cannabichromene), CBGV (cannabigerivarin), THCV (tetrahydrocannabivarine), CBDV (cannabidivarin) and CBCV (Canabichromevarin). As hemp hardens and loses moisture, acidic forms of cannabinoid compounds mature and are slowly converted to related compounds (e.g., THCA to THC). When hemp is cured and stored over time, only partial decarboxylation occurs, which is why hemp flowers are mostly positive in tests, e.g., for both THCA and THC (herein denoted THCA/THC). Because of this. When cannabis is smoked or vaporized, the presence of high temperatures decarboxylates the cannabinoids into acidic forms (e.g., THCA to THC), allowing them to be readily absorbed via inhalation.

The cannabinoid acid content of exemplary embodiments of an onsert, precision rod or precision pod herein, such as CBDA, includes the corresponding cannabinoid, as partial decarboxylation may have occurred in the cannabinoid acid, such as CBDA to CBD. Items quantified as containing 24 mg CBDA and 1 mg CBD, for example, onserts, precision rods, precision pods, cannabis plants, cannabinoid acids and cannabinoids assayed in cannabis strains and cannabis cultivars. is equivalent to the item described herein as 25 mg CBDA. Thus, due to the potential partial decarboxylation of cannabinoid acids to cannabinoids, cannabinoid acids and cannabinoids can sometimes be used interchangeably, in which case they can be expressed as 25 mg CBDA, 25 mg CBD or 25 mg CBDA/CBD. and it is understood herein that all of them have equivalent meanings.

Every strain or variety of cannabis has a unique cannabinoid profile, the content of each cannabinoid in a batch or blend of cannabis divided by the total content of all cannabinoids, which is measured as a ratio or percentage of one or more cannabinoids to one or more other cannabinoids . An example of a cannabinoid profile in a 10-pound batch of cannabis is one in which the THCA/THC content is 65% of the total content of all cannabinoids and the remaining cannabinoids comprise the remaining 35%. Non-THCA/THC cannabinoids may be further characterized. The ratio of THCA to CBDA is also an example of a cannabinoid profile. Multiple samples may be taken from a batch or plant, combined for testing purposes, and two or more replicates made. Regardless of cannabis strain or cultivar, CBDA/CBD and THCA/THC are generally the two most common cannabinoids in cannabis. There is generally an inverse relationship between THCA and CBDA across cannabis strains and cultivars. The higher the THCA/THC content, the lower the CBDA/CBD content, and the higher the CBDA/CBD content, the lower the THCA/THC content. CBDA/CBD is generally the most abundant cannabinoid combination in a hemp strain or cultivar. THCA/THC is the most abundant cannabinoid combination in the marijuana family, and typically can be approximately 10-20% of the weight of the hemp flower. This CBDA-CBD/THCA-THC relationship of hemp and marijuana has been shown to contain more CBDA/CBD as hemp has been bred for its seeds and biomass for centuries, whereas marijuana has been bred for its feel-good effects. This is due to the fact that it contains more THCA/THC according to the mange. A more accurate label for non-decarboxylated cannabis flowers is THCA, but if the flower is smoked, vaporized or heated in any way, THCA or THC are used interchangeably and are essentially the same; This is because THCA is converted to THC.

As described herein, the precise dosage formulation of a combination of one or more crystalline nicotine salts and one or more crystalline cannabinoids used with the devices disclosed herein (Onsert, Precision Rods and Precision Pods) is particularly suitable for simultaneous tobacco and marijuana use. Many types of hazard reduction products are provided for smokers. Cigarettes enhance the feel-good effects of marijuana when both are smoked simultaneously or when a cigarette is smoked immediately after smoking marijuana. This synergistic effect is due in part to nicotine's stimulating properties, such as increased heart rate. Some smokers combine cigarettes and marijuana into a blunt or spliff. A blunt is marijuana rolled into a cigar wrapper containing tobacco leaves or tobacco, and a spliff is also a joint containing tobacco. As blunts and spiffs burn, they produce harmful gases containing 'tar' and thousands of other chemicals. For example, inhaling smoke from burning high-purity forms of crystalline CBDA or THCA, along with burning crystalline salts of nicotine, and without any hemp and tobacco plant material, is less harmful than inhaling smoke from a blunt or spiff. , because these pure or near-pure crystal blends result in significant reductions in mainstream smoke for a given level of cannabinoids and nicotine. Also, vaping a high purity, blended form of crystalline THCA and crystalline nicotine salt in a precision pod, for example, with no propylene glycol and glycerin or with very low amounts (compared to e-cigarettes), can be blunt or spooly. Less harmful than smoking leaf. Propylene glycol and vegetable glycerin, in high percentages of e-liquids, are considered safe and acceptable as food additives; There are not enough data on long-term inhalation of these compounds. During the summer of 2019, reports of irritated and inflamed lungs from vaping e-liquids, including oils containing THC and vitamin E acetate, began to surface. Separately, studies have shown that inhaling nicotine-free e-cigarette aerosols transiently affect endothelial cell function in healthy non-smokers. See Caporale et al. , 2019, doi: 10.1148/radiol.2019190562. They highlight the usefulness of the devices disclosed herein to deliver concentrated formulations of active ingredients (eg, nicotine and cannabinoids) while eliminating or minimizing levels of carriers such as propylene glycol and glycerin. For a given dose of nicotine or THCA, whether smoking or vaping, for example, salts of THCA and/or nicotine in highly pure form produce less inhaled smoke than blunts or spliffs, ) Compared to vaping, less vapor is inhaled.

Any extraction method known in the art can produce cannabinoid acids in crystalline or near crystalline form. As measured by high performance liquid chromatography, these cannabinoid acids extracted are preferably at least 90% pure, more preferably at least 95% pure, more preferably at least 98% pure, more preferably at least 99% pure, and most preferably at least 99.5% pure. These extraction methods utilize liquid carbon dioxide (CO2) under supercritical or subcritical conditions, followed by at least one other further extraction, such as plant waxes, wax esters and glycerides, terpenes, carotenes, flavonoids and any using an ethanol precipitation method that removes a substantial fraction of the residual non-cannabinoid material of the See, eg, US Pat. Nos. 7,700,368 and 8,846,409.

9-테트라하이드로카나비놀산), CBDA(카나비디올산), CBCA(카나비크로멘산), CBGVA(카나비게로바린산), THCVA(테트라하이드로카나비바린산), CBDVA(카나비디바린산) 및 CBCVA(카나바이크로메바린산). 결정질 형태, 거의 결정질 형태, 다형성 결정질 형태, 및/또는 비정질 형태 여부에 관계없이, 임의의 니코틴의 염(니코틴 염)이, 다음으로부터 선택된 하나 이상을 포함하여 사용될 수 있다: 니코틴 4-아세트아미도벤조에이트, 니코틴 아스코르브산염, 니코틴 아스파르트산염, 니코틴 벤조에이트, 니코틴 중주석산염, 니코틴 염화물, 예컨대 니코틴 이염화수소산염 및 니코틴 염화수소산염, 니코틴 시트르산염, 니코틴 2,3-디하이드록시벤조에이트, 니코틴 3,5-디하이드록시벤조에이트, 니코틴 푸마르산염, 니코틴 겐티스산염 (2,5-하이드록시벤조산), 니코틴 글루타메이트, 니코틴 1-하이드록시-2-나프토에이트, 니코틴 3-하이드록시벤조에이트, 니코틴 락트산, 니코틴 레불린산, 니코틴 말산염, 니코틴 모노-피루브산염, 니코틴 뮤케이트, 니코틴 과염소산염, 니코틴 피루브산염, 니코틴 살리실산염, 니코틴 숙신산염, 니코틴 설페이트, 니코틴 타르타르산염 및 니코틴 염화아연.A combination of one or more cannabinoid acids and/or one or more nicotine salts may be included in an onsert, precision rod, or precision pod in any exemplary embodiment herein. Any cannabinoid acid, including those in crystalline or near crystalline form, may be used, including one or more cannabinoid acids selected from: CBGA (cannabigerolic acid), THCA (

9-tetrahydrocannabinolic acid), CBDA (cannabidiolic acid), CBCA (cannabichromenic acid), CBGVA (cannabigerovaric acid), THCVA (tetrahydrocannabivaric acid), CBDVA (cannabidivaric acid) and CBCVA (Canabichromebaric acid). Any salt of nicotine (nicotine salt), whether in crystalline form, near crystalline form, polymorphic crystalline form, and/or amorphous form, can be used, including one or more selected from nicotine 4-acetamido benzoate, nicotine ascorbate, nicotine aspartate, nicotine benzoate, nicotine ditartrate, nicotine chlorides such as nicotine dichloride and nicotine hydrochloride, nicotine citrate, nicotine 2,3-dihydroxybenzoate, nicotine 3 ,5-dihydroxybenzoate, nicotine fumarate, nicotine gentisate (2,5-hydroxybenzoic acid), nicotine glutamate, nicotine 1-hydroxy-2-naphthoate, nicotine 3-hydroxybenzoate, Nicotine lactate, nicotine levulinic acid, nicotine malate, nicotine mono-pyruvate, nicotine mucate, nicotine perchlorate, nicotine pyruvate, nicotine salicylate, nicotine succinate, nicotine sulfate, nicotine tartrate and nicotine zinc chloride.

Flavorings and Additives

In addition to alkaloids and cannabinoids, the onserts, precision rods and precision pods disclosed herein may also contain optional flavorings and/or additives. As disclosed in U.S. Patent Application No. 16/047,948, a method for facilitating conversion of a smoker to an e-cigarette or tobacco heating product allows the smoker to personalize an ultra-low nicotine cigarette using additives or to characterize flavors during treatment. Being available is important for smokers to better tolerate these unconventional cigarettes. For example, natural menthol crystals from peppermint oil or other mint oils may be included in any embodiment herein. Crystalline menthol is clear or white, and becomes a vapor when tobacco smoke passes through the crystals of a fine rod or when a fine pod is heated in a vaporizer to allow the essence of menthol to permeate the mainstream vapor. Menthol crystals, as solids, blend well with crystalline cannabinoid acids and crystalline salts of nicotine formulations. Any type of flavoring, whether in crystalline form or not, can be included in the onsert, precision rod, or precision pot; other examples of characterizing flavors include vanilla (e.g., vanillin), cherry, grape, mango, orange, clove, blueberry. , peach, cinnamon, coconut, licorice, chocolate, fruit, coffee, strawberry, pineapple, cucumber, lemon, lime, and toffee. Commercial cigarettes characterized and labeled as 'menthol' contain anywhere from about 2 mg to 20 mg of menthol. Any onsert, precision rod or precision pod contains at least 1 mg, 2 mg, 3 mg, 4 mg, 5 mg, 6 mg, 7 mg, 8 mg, 9 mg, 10 mg, 11 mg, 12 mg, 13 mg , 14 mg, 15 mg, 16 mg, 17 mg, 18 mg, 19 mg, 20 mg, 21 mg, 22 mg, 23 mg, 24 mg, 25 mg, 26 mg, 27 mg, 28 mg, 29 mg, 30 mg, 31 mg, 32 mg, 33 mg, 34 mg, 35 mg, 36 mg, 37 mg, 38 mg, 39 mg, 40 mg, 41 mg, 42 mg, 43 mg, 44 mg, 45 mg, 50 mg other and the like.

Additives are also important to enhance some of the formulations of the onsert, precision rod and precision pod examples herein. For example, formulations of salts of crystalline cannabinoids and nicotine lack flavor and aroma, since all plant terpenes have been extracted or none are present in the case of compounds under synthesis. Terpenes are pungent oils that give hemp its unique aroma and taste. All strains have unique terpene profiles. These hemp terpenes can be reintroduced into the formulation of onserts, precision rods and precision pods to add characteristics such as taste and aroma to smoke or vapors. Although over 100 terpenes have been identified, the most common terpenes in hemp include myrcene, caryophyllene, pinene, limonene and humulene.

Additives may also be used in exemplary embodiments of onserts, precision rods, or precision pods to improve the harsh taste of any of the crystalline nicotine salts, other crystalline alkaloids, crystalline cannabinoids, and/or other crystalline compounds. The pH of the smoke or vapor generated from the formulation of the onsert, precision rod and precision pod is analyzed and adjusted accordingly by the addition of components to shift the pH of the smoke or vapor. For example, if the pH of the smoke generated from the formulation of the precision pod under development is greater than about 5.5, a weak acid such as sugar, citric acid, or fatty acid may be added to the formulation within the precision pod, precision rod, or onsert. Plant materials or other ingredients may also be added to the formulations herein, including plant parts, plant fractions, or plant ingredients from medicinal herbs (eg, jasmine or ginseng), hemp, tobacco, and/or other plants. do.

Other functional additives such as preservatives or non-tobacco alkaloids such as cytisine, also known as cytisinicline, are useful. Cytisine is a plant alkaloid present in many plant families, such as Cytisus and Laburnum (eg Cytisus laborinum or golden rain acacia). Citicinicline has a high binding affinity for nicotinic acetylcholine receptors. It is used as a smoking cessation treatment in pill form in some European countries. In some exemplary embodiments, including at least 2 mg of citicinicline in an onsert, precision rod, or precision pod, reduces the urge to smoke a conventional cigarette, allows smokers to switch to an e-cigarette or tobacco heating product, or to smoke a cigarette. and helping to completely stop nicotine use.

In some aspects of the invention, factory-made nicotine content is used to encourage smokers who are not interested in completely quitting cigarettes and nicotine products to switch from smoking conventional cigarettes to using e-cigarettes or tobacco heating devices. Products and formulations are provided for smokers to improve the nicotine, anatabine and/or anabasin smoke yields (ie levels) of smoking products such as these very low cigarettes. In this methodology, the ultra-low nicotine cigarette is used as a bridge between a smoker's predominant cigarette brand and an e-cigarette or between a smoker's predominant cigarette brand and a cigarette heating device.

In another aspect, products and formulations are provided for smokers to improve the nicotine smoke yield of conventional factory manufactured cigarettes to reduce the smoker's exposure to cigarette smoke containing 'tar' and carbon monoxide.

In another aspect, products for adding new characteristic flavor(s) or enhancing flavor(s) in the smoke of tobacco products, such as cigarettes, are provided for smokers.

In another aspect, a product for adding nicotine, anatabine and/or anabasin to a marijuana cigarette is provided for smokers.

In another aspect, products for incorporating cannabinoids or other additives or ingredients into smoking products are provided for smokers.

In another aspect, products and formulations are provided that enable smokers to enjoy the effects of cannabinoids and nicotine without exposure to non-nicotine tobacco compounds.

Example 1

Onserts for Smoking Products

To improve nicotine smoke yield, nicotine is combined with an onsert such that a consumer applies the onsert on, around, or in a smoking product such as a cigarette. Nicotine adhered to or injected into the onsert is preferably in the form of a salt of nicotine. The onsert, made of cellulose (eg, reconstituted hemp) or consisting of a wrapper comprising cellulose, may be approximately as long as a smoking article, such as a cigar, and may be of any shape or size, including a width sufficient to enclose the cigarette. there is. As shown in Figures 1a - 1c, the onsert 1 comprising the cellulose wrapper 2 is configured to wrap around the entire circumference of the cigarette rod 3 of a factory manufactured cigarette. The width of the cellulose wrapper 2 of the onsert 1 is larger than the circumference of the cigarette so that both sides 4 and 5 of the onsert overlap the cigarette rod to sufficiently seal the cigarette. The self-adhesive (self-adhesive) side (6) of the onsert (1) has a self-adhesive adhesive around the entire perimeter of the onsert (all four sides) (7) and attaches the onsert to the cigarette rod (3). It is rolled around the cigarette rod 3 while pressurizing it. Referring to FIGS. 1A and 1B , a nicotine salt 8 or nicotine in any other form (along with any other compounds or ingredients the Onsert may include) is adhered to the cellulose wrapper 2 of the Onsert and , in this exemplary embodiment, there is no nicotine on the opposite side 9 of the onsert 1 . Alternatively, in some exemplary embodiments, nicotine and any other compounds or ingredients are added by methods known in the art, such as for reconstituting plant material (eg, reconstituted tobacco sheets or reconstituted hemp sheets). It is injected into the cellulose wrapper during the production process. In another exemplary embodiment, nicotine is enclosed between closed pockets (ie, envelops or closed pouches) of opposing sheets by methods known in the art for producing sugar packets or silica gel packets.

As shown in FIG. 1C , the entire cigarette rod 3 is now wrapped within the onsert 1 . The onsert 1 and the cigarette are bonded together, and the smoker presses along the length of the nicotine-enhanced cigarette at the joint 10 to improve sealing. The self-adhesive onserts may be packaged for supply in any form, such as a non-adhesive sheet (backing paper), each sheet comprising at least one onsert that peels off from the non-adhesive sheet, or There may be a self-adhesive onsert on a continuous roll of a series of multiple onserts that are peeled off the roll one at a time from the backing paper. Although self-adhesive onserts are preferred, adhesives that are activated when wet (eg, when wet) to adhere may also be used. Any moisture activated adhesive known in the art can be used for the onsert.

When a cigarette is lit and smoked, some of the nicotine is transferred from the onsert into the mainstream smoke and becomes part of the mainstream smoke. Onsert is any cellulosic material in the form of a wrapper or strip that is combustible and smokeable, such as paper or cellulosic material, cigarette paper, reconstituted tobacco sheets including those used to roll machine-manufactured cigars, reconstituted hemp sheets, hemp paper and/or cellulosic materials made from other plants, such as herbal plants (eg, ginseng or jasmine). An advantage of the onsert configuration of FIGS. 1A-1C is that other ingredients can be easily added to the onsert (between the onsert and the cigarette), and then the onsert can be completely rolled around the cigarette.

In some exemplary embodiments, the onsert is fabricated by covering the onsert with a nicotine salt along with binders, stabilizers, and/or adhesives known in the art. In this methodology, for example, about 3 parts gum arabic (derived from the acacia tree and also known as gum arabic or gum acacia) is mixed with about 1 part glycerin and about 1/6 part water in a vessel for 15 minutes, Creates an adhesive that retains the nicotine salt on the onsert. A thin coat of binder, stabilizer or adhesive may be applied to the uncut sheet (eg, hemp paper) after formation on the same and/or opposite sides of the self-adhesive side to adhere the onsert onto the cigarette. can When the nicotine salt is applied to the self-adhesive surface, as shown in Fig. 1A, nothing is applied where there is adhesive, such as around the border 7 of the onsert. A nicotine salt covering in powder or flake form is then applied to one or both sides of the sheet at a desired rate immediately after application of the binder, stabilizer or adhesive, causing the nicotine salt coating to adhere to the sheet. After drying, a subsequent coating of a binder, stabilizer or adhesive and nicotine salt may be applied to the sheet. A binder, stabilizer or adhesive may be applied as a final coat to better capture the nicotine on the sheet. The uncut sheet is then cut into a number of onserts in desired shapes and sizes. An onsert configured to wrap around the entire circumference of a smoking article may be of any size, eg sized to completely wrap a cigar or 100 mm cigarette. Thus, the size and type of smoking article partially determines the size and configuration of the onsert. Additionally, the amount of nicotine salt (and/or other compound) applied to the onsert is based on the type and nature of the smoking article (e.g., level of ventilation) and the desired level of increase in nicotine yield (or the level of increase in yield of any other compound desired). do. Thus, the increase in nicotine yield (or other compound yield) is a function of the type and characteristics of the smoking article and the type and size of the onsert used, including the level of compound incorporated into or on the onsert.

In another exemplary embodiment, the nicotine salt along with other compounds can be injected between two onsert sheets or between two or more onsert sheets, the onsert sheets covered with the nicotine salt on the outer portion of each sheet. or not covered In this fabrication arrangement, using the gum arabic formulation (or any other binder, stabilizer or adhesive formulation employed), two or more sheets or onserts are formed after the sheets are subsequently cut into multiple onserts for packaging. The edge of can be sealed. A self-adhesive onsert is preferably used in this embodiment for the consumer to peel and apply the nicotine onsert onto a cigarette or other smoking article. By covering the onsert sheets with nicotine and not gluing, the nicotine in this fabrication arrangement remains enclosed between the sheets for an inherently cleaner consumer application.

The nicotine onserts disclosed herein (and the precision rods and precision pods disclosed and described below) may also contain other alkaloids, flavors, cannabinoids, terpenes, and/or other additives or ingredients. For example, any one of the exemplary embodiments herein, whether in nicotine salt form, nicotine co-crystal form, or nicotine salt co-crystal form, including the exemplary onsert embodiment of FIGS. 1A-1F , , using anatabine or anabasin in place of or in combination with nicotine. Both anatabine and anabasin are alkaloids similar to nicotine, and instead of producing a nicotine salt, a salt of anatabine or a salt of anabasin can be produced for anatabine-enhanced cigarettes and anabasin-enhanced cigarettes. The nicotine salt can be combined with the anatabine salt and/or the anabasin salt, wherein the anatabine salt can be combined with the anabasin salt for marijuana cigarettes or for cigarettes having any level or combination of enhanced nicotine, enhanced anatabine, or enhanced anabasin. can be combined. Synthetic versions of these alkaloids may also be used.

9-테트라하이드로카나비놀산(

9-tetrahydrocannabinolic acid, THCA), 카나비디올산(cannabidiolic acid, CBDA), 카나비크로멘산(cannabichromenenic acid, CBCA), 카나비게롤산(cannabigerolic acid, CBGA), 테트라하이드로카나비바린산(tetrahydrocanabivarinic acid, THCVA), 카나비디바린산(cannabidivarinic acid, CBDVA), 카나비크로메바린산(cannabichromevarinic acid, CBCVA), 카나비게로바린산(cannabigerovarinic acid, CBGVA), 미르센(myrcene), 카리오필렌(caryophyllene), 피넨(pinene), 리모넨(limonene) 및 휴뮬렌(humulene)으로 이루어진 군으로부터 선택되는 하나 이상의 화합물을 포함할 수 있다. 각각의 온서트는 적어도 다음의 양의 전술한 화합물 각각을 포함할 수 있다: 0.10 mg, 0.20 mg, 0.30 mg, 0.40 mg, 0.50 mg, 0.60 mg, 0.70 mg, 0.80 mg, 0.90 mg, 1.0 mg, 1.1 mg, 1.2 mg, 1.3 mg, 1.4 mg, 1.5 mg, 1.6 mg, 1.7 mg, 1.8 mg, 1.9 mg, 2 mg, 3 mg, 4 mg, 5 mg, 6 mg, 7 mg, 8 mg, 9 mg, 10 mg, 11 mg, 12 mg, 13 mg, 14 mg, 15 mg, 16 mg, 17 mg, 18 mg, 19 mg, 20 mg, 21 mg, 22 mg, 23 mg, 24 mg, 25 mg, 26 mg, 27 mg, 28 mg, 29 mg, 30 mg, 31 mg, 32 mg, 33 mg, 34 mg, 35 mg, 36 mg, 37 mg, 38 mg, 39 mg, 40 mg, 41 mg, 42 mg, 43 mg, 44 mg, 45 mg, 46 mg, 47 mg, 48 mg, 49 mg, 50 mg, 51 mg, 52 mg, 53 mg, 54 mg, 55 mg, 56 mg, 57 mg, 58 mg, 59 mg, 60 mg, 61 mg, 62 mg, 63 mg, 64 mg, 65 mg, 66 mg, 67 mg, 68 mg, 69 mg, 70 mg, 71 mg, 72 mg, 73 mg, 74 mg, 75 mg, 76 mg, 77 mg, 78 mg, 79 mg, 80 mg, 81 mg, 82 mg, 83 mg, 84 mg, 85 mg, 86 mg, 87 mg, 88 mg, 89 mg, 90 mg, 91 mg, 92 mg, 93 mg, 94 mg, 95 mg, 96 mg, 97 mg, 98 mg, 99 mg, 100 mg, 110 mg, 120 mg, 130 mg, 140 mg, 150 mg, 160 mg, 170 mg, 180 mg, 190 mg, 200 mg, 250 mg 기타 등등. 예를 들어, 온서트는 적어도 30 mg의 니코틴을 함유할 수 있고, 위에 열거된 임의의 다른 성분을 함유하지 않을 수 있거나, 예를 들어, 적어도 10 mg 니코틴, 적어도 10 mg THCA 및 적어도 10 mg CBCA를 함유할 수 있다. 온서트는 하나 보다 많은 알칼로이드, 화합물 또는 첨가제를 함유할 수도 있다. 일부 예시적인 실시예에서, 도 1a에 도시된 온서트의 유형과 같은온서트는 구체적으로 MYO 또는 RYO 완제품 담배 블렌드를 포함하는 대마 및/또는 담배를 온서트 내로 직접 마는 데 사용될 수 있다. 다른 예시적인 실시예에서, 온서트는 전술한 하나 이상의 화합물 중 어느 하나를 포함하거나 포함하지 않고, 전술한 양(즉, 적어도 0.10 mg 내지 적어도 250 mg)의 종래의 담배, 저 니코틴 담배, 종래의 대마(즉, 마리화나) 및/또는 초저 THC 대마 중 어느 하나를 포함할 수 있다.Each onsert, regardless of type, contains nicotine, anatabine, anabasin, flavor,

9-tetrahydrocannabinolic acid (

9-tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA), cannabichromenenic acid (CBCA), cannabigerolic acid (CBGA), tetrahydrocanabivarinic acid (THCVA) , cannabidivarinic acid (CBDVA), cannabichromevarinic acid (CBCVA), cannabigerovarinic acid (CBGVA), myrcene, caryophyllene, pinene ), at least one compound selected from the group consisting of limonene and humulene. Each onsert may contain at least the following amounts of each of the foregoing compounds: 0.10 mg, 0.20 mg, 0.30 mg, 0.40 mg, 0.50 mg, 0.60 mg, 0.70 mg, 0.80 mg, 0.90 mg, 1.0 mg, 1.1 mg, 1.2 mg, 1.3 mg, 1.4 mg, 1.5 mg, 1.6 mg, 1.7 mg, 1.8 mg, 1.9 mg, 2 mg, 3 mg, 4 mg, 5 mg, 6 mg, 7 mg, 8 mg, 9 mg, 10 mg, 11 mg, 12 mg, 13 mg, 14 mg, 15 mg, 16 mg, 17 mg, 18 mg, 19 mg, 20 mg, 21 mg, 22 mg, 23 mg, 24 mg, 25 mg, 26 mg , 27 mg, 28 mg, 29 mg, 30 mg, 31 mg, 32 mg, 33 mg, 34 mg, 35 mg, 36 mg, 37 mg, 38 mg, 39 mg, 40 mg, 41 mg, 42 mg, 43 mg, 44 mg, 45 mg, 46 mg, 47 mg, 48 mg, 49 mg, 50 mg, 51 mg, 52 mg, 53 mg, 54 mg, 55 mg, 56 mg, 57 mg, 58 mg, 59 mg, 60 mg, 61 mg, 62 mg, 63 mg, 64 mg, 65 mg, 66 mg, 67 mg, 68 mg, 69 mg, 70 mg, 71 mg, 72 mg, 73 mg, 74 mg, 75 mg, 76 mg , 77 mg, 78 mg, 79 mg, 80 mg, 81 mg, 82 mg, 83 mg, 84 mg, 85 mg, 86 mg, 87 mg, 88 mg, 89 mg, 90 mg, 91 mg, 92 mg, 93 mg, 94 mg, 95 mg, 96 mg, 97 mg, 98 mg, 99 mg, 100 mg, 110 mg, 120 mg, 130 mg, 140 mg, 150 mg, 160 mg, 170 mg, 180 mg, 190 mg, 200 mg, 250 mg and so on. For example, the onsert may contain at least 30 mg of nicotine and may not contain any of the other ingredients listed above, or may contain, for example, at least 10 mg nicotine, at least 10 mg THCA and at least 10 mg CBCA. may contain An onsert may contain more than one alkaloid, compound or additive. In some exemplary embodiments, an onsert, such as the type of onsert shown in FIG. 1A , may be used to roll hemp and/or tobacco directly into the onsert, specifically including MYO or RYO finished tobacco blends. In another exemplary embodiment, the onsert comprises or does not comprise any one of the one or more compounds described above, and the amount described above (i.e., from at least 0.10 mg to at least 250 mg) of conventional tobacco, low nicotine cigarette, conventional hemp (ie, marijuana) and/or very low THC hemp.

In some exemplary embodiments, the self-adhesive or moisture-activated adhesive is on the same side of the one or more compounds and the cellulose wrapper, and in other embodiments, the adhesive is on opposite sides of the one or more compounds and the cellulose wrapper. In another embodiment, the one or more compounds are within a shell, and the shell may be in the center of the cellulosic wrapper. The onsert may contain nicotine, anatabine or non-extracted nicotine from the Nicotiana plant in any of the above amounts (ie, from at least 0.10 mg to at least 250 mg), whether the compound is enclosed within or adhered to the cellulose wrapper. anavasin; That is, it may contain any compound or combination of compounds, including synthesized nicotine, anatabine or anabasin, wherein the onsert will contain the above amounts (i.e., from at least 0.10 mg to at least 250 mg) of one or more of the following cannabinoid acids: Can be: THCA, CBDA, CBCA, CBGA, CBGVA, THCVA, CBDVA and CBCVA which are synthetic, i.e. produced outside the cannabis plant.

Any strain, cultivar or blend of cannabis is enhanced by an onsert comprising one or more cannabinoids to roll a marijuana strain, strain or blend of cannabis flowers or other plant parts into an onsert, such as the onsert type shown in Figure 1A. It can be. This is sometimes necessary because the cannabinoid profile of dozens of cannabinoids, including THCA/CBDA ratios and contents, of flowers of the same marijuana strain can vary considerably from one crop to another, especially when grown under different growing conditions. These onserts can be nicotine-free and tobacco-free, and are an ideal way to modify the cannabinoid profile of smoke from any strain, variety, or blend of cannabis flowers without requiring additional strains, varieties, or blends of cannabis flowers. For example, onserts can be used to enhance the cannabis user's marijuana cigarette, blunt, or spiff or to alter the cannabinoid profile of smoke from any cannabis strain, variety, or blend to achieve a desired effect, such as THCA, CBDA, CBGA, and/or any other cannabinoid.

90 순수)인 경우에 그러하다. 실제로, (임의의 카나비노이드 중량에 더하여) 평균 약 650 mg의 담배인, 궐련(추가된 카나비노이드를 갖거나 갖지 않음)와 비교하여, 예를 들어, 온서트 내로 말린 20mg의 THCA, 10mg의 니코틴 염 및 200mg의 식물 재료(담배, 대마 또는 둘의 배합물인지 여부)를 포함하는 흡연 제품용 온서트는 식물 재료가 약 69% 적은 흡연 제품으로 변환된다. 이는 결과적으로 평균적인 궐련(추가된 카나비노이드를 갖거나 갖지 않음)와 비교하여, 온서트로부터의 '타르' 흡입을 포함하는 연기 흡입의 상당한 감소가 있을 것임을 의미한다. 또한, 온서트와 함께 담배가 덜 사용되기 때문에 발암성 TSNA의 상당한 감소가 있을 것이다.Rolling cannabis and/or tobacco directly into the onsert, in addition to the benefit that any compound present on the onsert may be included as a new compound not present in the smoking product or provided as an adjunct to a compound already present in the smoking product. The onsert design shown in FIG. 1A for this purpose has other important advantages over conventional RYO cigarettes or RYO marijuana cigarettes. For example, onserts are more convenient and less messy, especially when implemented as self-adhesive onserts, and onserts provide a seal on all four sides, reducing smoke dilution from unwanted airflow caused by loose rolls. Decrease. In addition, less tobacco or hemp may be used, especially if the nicotine and/or cannabinoids contained with the onsert are pure or semi-pure (e.g.,

90 pure). In fact, compared to cigarettes (with or without added cannabinoids), which averages about 650 mg of tobacco (in addition to any cannabinoid weight), for example, 20 mg of THCA rolled into an onsert, 10 mg of a nicotine salt and An onsert for a smoking product containing 200 mg of plant material (whether tobacco, hemp or a combination of the two) converts to a smoking product with approximately 69% less plant material. This consequently means that there will be a significant reduction in smoke inhalation, including inhalation of 'tar' from the onsert, compared to an average cigarette (with or without added cannabinoids). Also, there will be a significant reduction in carcinogenic TSNA because less tobacco is used with Onsert.

In some exemplary embodiments, synthetic nicotine may be the only active ingredient included with the onsert (or with the precision rod) so that cannabis users can enjoy the effects of nicotine (not extracted from tobacco) with cannabis. An onsert that provides nicotine to mainstream smoke from a marijuana cigarette (e.g., dried hemp with an onsert such as the onsert of FIGS. 1A-1C), whether synthetic nicotine or nicotine extracted from the Nicotiana plant is used. or precision rods containing nicotine) effectively eliminates the need to include any tobacco and is consequently a less harmful smoking product compared to splips, as there is less plant material that needs to be burned as tobacco is not required for nicotine content; This is because it reduces smoke inhalation and removes tobacco carcinogens such as TSNA.

It is to be understood that the onsert herein may be of any shape or form, and any self-adhesive adhesive (or other adhesive, such as an adhesive requiring moisture for activation) on the onsert may be continuous or in any pattern. will be. For example, the self-adhesive adhesive is on all four sides 7 surrounding the nicotine salt 8 of the onsert 1 of FIG. 1A. In modified exemplary embodiments, one, two or three sides of the onsert may include a self-adhesive adhesive (or other adhesive, such as one that requires moisture to activate), or one or more additional adhesives. A strip may be added, for example, through any axis of symmetry of the onsert. Any percentage of either side of the onsert may be composed of adhesive. An onsert, including the onsert of FIGS. 1A-1F , may include a filter to be attached to one end of the onsert. Combustion promoters or ash reformers may be included in or on the onsert. The onsert may also be placed inside a roll of rolled paper (RYO) that the smoker rolls before rolling or making the smoking product, or placed inside a hollow MYO cigarette tube (or in the case of RYO or MYO, loose tobacco or blended into hemp) can be used more as an 'insert' at this point (i.e. the on-insert is hidden after making a RYO smoking product or after making a MYO smoking product). When used in this manner, compared to placing the same onsert on the exterior of the smoking article (e.g., on a filled MYO cigarette), one or more alkaloids, flavors, cannabinoids, The delivery rate of terpenes and/or other additives is generally higher. Of course, for onserts specifically formulated to be placed inside a RYO or MYO smoking article, the self-adhesive adhesive feature may be any material that is activated when wet (eg, when spit) to adhere to the smoking article. As with other adhesives, this is optional. Embodiments of these exemplary onserts that can be inserted into a smoking article may not include any adhesive that adheres to the smoking article.

1D-1F shows an exemplary configuration of a self-stick onsert composed of a cellulose wrapper shaped differently from the onsert of FIGS. 1A-1C. As shown in FIG. 1D, the first type of onsert comprises a circular window 11 with two wings 12 or four wings 13 and contains one or more alkaloids, flavors, cannabinoids, terpenes and/or other Contains additives. Each of these onserts is positioned around a circular tip of a smoking article, such as a cigarette, cigar or marijuana cigarette, and the wings, which may be of any length, are extended and glued to the smoking article. Another type is the elongated onsert 14 shown in FIG. 1E , which may be placed in parallel along the side of a smoking article such as a cigar, for example, or one or both onserts may be wrapped around the smoking article. there is. In the exemplary embodiments of FIGS. 1D-1E , alkaloids, flavors, cannabinoids, terpenes and/or other additives may be encapsulated between closed pockets of opposing sheets of the onsert during the manufacturing process of the onsert, and may be incorporated into the adhesive. It may be adhered to either side of the onsert by or may be injected into the onsert.

Another type of onsert configuration is the web pattern onsert shown in the exemplary embodiment of FIG. 1F, similar to the onsert of FIGS. 1A-1C, where the onsert may be wrapped around a smoking article, such as a cigarette, and/or can be used with cannabis to roll a cigarette, marijuana cigarette, blunt or spiff (RYO), or can be rolled and smoked by itself without any interdependent smoking products. On the self-adhesive adhesive side of the onsert 15, around the webbing 16, 1, 2, There may be 3 or 4 adhesives. Discontinuous (ie web) onserts of this type may be of any shape or size and may cover any portion of the smoking article.

In some exemplary embodiments, the onserts may be included inside a pack of factory manufactured cigarettes, or may be bundled together (eg, 20) and glued to the outside of a cigarette pack or rolling paper box as packaging onserts. The advantage of packaging nicotine in or on factory-manufactured cigarette packs is that, as outlined in U.S. Patent Application Serial No. 16/047,948, it is possible to use ultra-low nicotine cigarettes exclusively for conversion from conventional cigarettes to e-cigarettes or tobacco heating devices. It is the convenience that these packaging presents when some smokers may require a supplemental amount of nicotine. These nicotine-enhanced cigarettes (e.g., nicotine onsert + ultra-low nicotine cigarettes) assist the smoker to exclusively use ultra-low nicotine cigarettes during the treatment period, as directed by the protocol, so that the smoker is Do not cheat or smoke conventional cigarettes. The supplemental amount of nicotine provided by the nicotine onsert(s) can increase nicotine smoke yield, eg, from 0.04 mg to 0.10 mg per cigarette. Although the nicotine smoke yields more than 2-fold in this example, the nicotine yield of 0.10 mg is still dramatically lower than the nicotine yield of 1 mg of conventional cigarettes. Nicotine onserts, which provide a supplemental amount of nicotine to conventional factory-manufactured cigarettes, provide smokers with great flexibility to personalize their cigarettes to smoke each cigarette less. A nicotine-enhanced cigarette in which an onsert containing nicotine is attached to a conventional cigarette reduces the tar-to-nicotine ratio.

Example 2

Precision Rods for Smoking Products

Precision rods containing precise amounts of one or more flavors, alkaloids, cannabinoids, terpenes and/or other additives, or ingredients are inserted into a smoking product, thereby adding one or more flavors, alkaloids, cannabinoids, terpenes and/or other additives, or ingredients. It is designed to remain in the smoking article during combustion of the smoking article, for the purpose of transferring into the mainstream smoke produced by the smoke. A precision rod provides a precisely quantified formulation of a compound of interest, either as an adjunct to the inherent content of one or more compounds already in a smoking article or as one or more new compounds. There are three types of precision rods. A first type of precision rod consists of a material that burns and burns as a smoking product, such as a cigar, burns. A suitable cellulosic material for this type of precision rod is one with an ignition temperature of 350°C or less. Ignition temperature is the lowest temperature at which a substance begins to burn. These materials must also be sufficiently hard (or made by design to be sufficiently rigid) that they can be inserted, for example, into the cigarette end of a filtered cigarette and have unacceptable levels of mainstream smoke in smoking products. It should be able to burn with the smoking product without providing any of the toxins. Examples of materials suitable for cellulosic precision rods include, but are not limited to, fiberboard, paper, cardboard or other cellulosic or wood materials, which are preferably hemp or reconstituted hemp, tobacco or reconstituted tobacco, or Flavors, alkaloids, cannabinoids, terpenes, and/or other additives, or ingredients of interest, are produced from other plants that are adhered to or housed (contained) within chambers or hollow spaces within precision rods. In some exemplary embodiments of the Precision Rod (and Precision Pod), the compounds and ingredients are reconstituted hemp, reconstituted tobacco, or other plant material that is reconstituted and then contained in the space or interior chamber of the Precision Rod (or compartment of the Precision Pod). included in

As shown in the exemplary embodiment of FIG. 2A, the cellulosic precision rod 18 is made up of six layers of multi-ply cardboard 19, each layer of which is, for example, nicotine salt ( and/or any other compound), then all layers are bonded together by a binder or adhesive that is generally recognized as safe (GRAS) by the US Food and Drug Administration (FDA). A cellulosic precision rod can include one or more layers of cellulosic material. One or more layers of cellulosic precision rods are bonded together during the production process of the layer(s) so that no additional binders or adhesives are required. The entire assembled precision rod can be covered with a thin GRAS coating or film to keep the compound sealed on the precision rod and out of the user's hand. In another exemplary embodiment, one or two thick layers may be used for the cellulosic precision rod, and this type of cellulosic precision rod using thick layers may also be used to accommodate higher amounts of nicotine salts and/or other compounds. It may include at least one chamber or hollow space.

The second type of precision rod in another exemplary embodiment is constructed of a material that does not burn or burn as the smoking article burns and has an ignition temperature greater than 350°C. These precision rods are composed of one or more flavors, alkaloids, cannabinoids, terpenes and/or other additives, or ingredients of interest, and are inserted into both ends of a smoking article to deliver these compounds or ingredients into the mainstream smoke produced by the smoking article. For the purpose, it is designed to remain in the smoking article during combustion of the smoking article. Examples of suitable refractory, hard materials include, but are not limited to, fused quartz or silica, ceramics such as earthenware or porcelain, or non-toxic ultra-high temperature ceramics. Non-toxic metals or metal alloys such as titanium or food grade stainless steel may also be used in embodiments where the precision rod will only snap a few times so that it cannot exit the smoking article and burn the smoker.

As shown in FIG. 2B , there are three exemplary embodiments of cylindrical precision rods of various sizes, including the first precision rod 20, that do not burn or burn as the smoking article burns. These three precision rods consist of internal chambers that contain compounds and/or plant matter. The inner chamber 21 starts at the opening at the end of the first precision rod 20 and has a diameter of about 1.25 mm and a length of about 13 mm. The first precision rod 20 contains about 15 mg of nicotine salt in powder form (density of about 900 kg/m 3 ) in the inner chamber 21 . One end of each precision rod may be pointed for easy insertion into any smoking article such as a factory cigarette. The precision rod also includes one or more holes or vents leading to the inner chamber 21 . Each precision rod in Figure 2b has a variety of holes 22 (only some of which are labeled). The number of holes or vents depends on the type of smoking article, the types of compounds or ingredients included in the precision rod and their boiling points, the amount of each compound in the precision rod, and the total weight of the contents in the precision rod. The hole or vent and the end opening of the precision rod all lead to an internal chamber, which facilitates the flow of air, heat and smoke into and out of the precision rod. The end opening and hole or vent of the precision rod may be sealed with gum arabic or any GRAS material that melts easily when heated. The hole or vent can be left unsealed, in which case the particle size of the compound is made larger than the hole or vent, and the compound is inserted through the end opening during production. The end opening may be covered with a peel tab that the consumer removes prior to inserting the precision rod into the smoking article. The entire precision rod can be sealed in plastic for the consumer to peel off prior to use.

As shown in FIG. 2C , the precision rod 20 of FIG. 2B has been inserted into the cigarette 23 . When the nicotine-enhanced cigarette, which now contains the precision rod, is smoked, the hole absorbs air, heat and heat as the nicotine (and/or other compounds in other exemplary embodiments) contained within the rod vaporizes and penetrates into the mainstream smoke. Allow smoke to enter the precision rod. When the nicotine-enhanced cigarette 23 (or other smoking article in another embodiment) is partially smoked, the cigarette is extinguished, or a precision rod may be ejected with the cigarette's ashes. A smoker would probably be happy with only a portion of nicotine-enhanced cigarettes being smoked (e.g., 40%) due to the adjuvant nicotine in a 15 mg precision load. The smoker can either discard the partially smoked cigarette or, if another precision rod can be inserted into the remainder of the cigarette, the unsmoked portion can be saved for later. In either case, the smoker inhales approximately half of the smoke, including the 'tar', compared to smoking the same cigarette without the precision rod. The amount of nicotine inhaled is about the same as if the same cigarette without precision load was smoked, since the average cigarette contains about 15 mg of nicotine; Equal amount within the precision rod. In addition to reducing harm, smokers also have the option to benefit economically by purchasing fewer cigarettes, when the other half of each cigarette is saved.

The first two types of precision rods may also be inserted into the mouth end of a smoking article, which may be a filter of the smoking article, such as a filtered cigarette or a filtered cigar. For example, a precision rod containing 8 mg of menthol crystals can be inserted into the mouth end of a cigarette (eg filter end). The holes or vents in the precision rod allow the essence of the menthol crystals to enter the mainstream smoke and deliver the menthol sensation and satisfaction to the smoker. Since smoking an ultra-low nicotine cigarette has no significant effect on the throat compared to smoking a conventional cigarette, the menthol or other flavor(s) in the precision rod increases the likelihood of accepting the ultra-low nicotine cigarette, which Facilitates smokers to completely quit tobacco products, and facilitates smokers to switch to electronic cigarettes or tobacco heating devices (disclosed in US Patent Application Serial No. 16/047,948). E-cigarettes and tobacco heating devices are generally recognized as far less harmful than smoking cigarettes. For example, vaping an e-cigarette is believed to be about 90% less harmful than smoking a cigarette.

A third type of precision rod is used with flavor injection systems. Precision rods of this type also contain one or more flavors, alkaloids, cannabinoids, terpenes, and/or other additives, or ingredients, and are incorporated into one or more cigarettes or smoking products such as cigars. The compound in the inner chamber is injected into the smoking article and then the precision rod is removed from the smoking article. As shown in FIG. 2D , the flavor injection system includes a precision rod 24 and a plunger mechanism 25 . The plunger mechanism 25 includes a plunger not shown in FIG. 2D. The precision rod 24 includes a locking mechanism at one end, which in this exemplary embodiment is a thread 26 allowing the precision rod to be screwed into the thread 27 of the plunger mechanism 25 . The precision rod includes an end hole 28, which is the beginning of an internal chamber that receives the compound or ingredient before it is injected into the smoking article. Once the precision rod 24 is inserted into the smoking article, then the precision rod and plunger mechanism 25 are connected (or the order may be reversed), and the plunger connected to the plunger mechanism is pushed into the plunger mechanism 25. It is retracted and the contents in the precision rod are emptied into the smoking article. When the smoking article is ignited, the mainstream smoke of the smoking article will be injected along with one or more compounds (and any ingredients) currently included in the smoking article.

In some exemplary embodiments, the flavor injection system and precision rod are integral and do not need to be connected. Flavors, alkaloids, cannabinoids, terpenes and/or other additives or ingredients can be loaded directly into the plunger mechanism or precision rod by a variety of methods. For example, the plunger can be removed from the plunger mechanism, and compounds and ingredients are emptied or placed into the plunger mechanism that passes into the precision rod. Then reattach the plunger. The flavor injection system is now ready to inject the smoking product along with the contents within the flavor injection system. Any of the foregoing exemplary embodiments of a flavor injection system may be automated with any type of machine in which one or more smoking articles, such as one or more cigarettes, are injected with the compound either one time or continuously.

9-테트라하이드로카나비놀산(

9-tetrahydrocannabinolic acid, THCA), 카나비디올산(cannabidiolic acid, CBDA), 카나비크로멘산(cannabichromenenic acid, CBCA), 카나비게롤산(cannabigerolic acid, CBGA), 테트라하이드로카나비바린산(tetrahydrocanabivarinic acid, THCVA), 카나비디바린산(cannabidivarinic acid, CBDVA), 카나비크로메바린산(cannabichromevarinic acid, CBCVA), 카나비게로바린산(cannabigerovarinic acid, CBGVA), 미르센(myrcene), 카리오필렌(caryophyllene), 피넨(pinene), 리모넨(limonene) 및 휴뮬렌(humulene)으로 이루어진 군으로부터 선택되는 하나 이상의 화합물을 포함할 수 있다. 3가지 유형의 정밀 로드 각각은 적어도 다음의 양의 전술한 화합물 중 하나 이상을 포함할 수 있다: 0.10 mg, 0.20 mg, 0.30 mg, 0.40 mg, 0.50 mg, 0.60 mg, 0.70 mg, 0.80 mg, 0.90 mg, 1.0 mg, 1.1 mg, 1.2 mg, 1.3 mg, 1.4 mg, 1.5 mg, 1.6 mg, 1.7 mg, 1.8 mg, 1.9 mg, 2 mg, 3 mg, 4 mg, 5 mg, 6 mg, 7 mg, 8 mg, 9 mg, 10 mg, 11 mg, 12 mg, 13 mg, 14 mg, 15 mg, 16 mg, 17 mg, 18 mg, 19 mg, 20 mg, 21 mg, 22 mg, 23 mg, 24 mg, 25 mg, 26 mg, 27 mg, 28 mg, 29 mg, 30 mg, 31 mg, 32 mg, 33 mg, 34 mg, 35 mg, 36 mg, 37 mg, 38 mg, 39 mg, 40 mg, 41 mg, 42 mg, 43 mg, 44 mg, 45 mg, 46 mg, 47 mg, 48 mg, 49 mg, 50 mg, 51 mg, 52 mg, 53 mg, 54 mg, 55 mg, 56 mg, 57 mg, 58 mg, 59 mg, 60 mg, 61 mg, 62 mg, 63 mg, 64 mg, 65 mg, 66 mg, 67 mg, 68 mg, 69 mg, 70 mg, 71 mg, 72 mg, 73 mg, 74 mg, 75 mg, 76 mg, 77 mg, 78 mg, 79 mg, 80 mg, 81 mg, 82 mg, 83 mg, 84 mg, 85 mg, 86 mg, 87 mg, 88 mg, 89 mg, 90 mg, 91 mg, 92 mg, 93 mg, 94 mg, 95 mg, 96 mg, 97 mg, 98 mg, 99 mg, 100 mg, 110 mg, 120 mg, 130 mg, 140 mg, 150 mg, 160 mg, 170 mg, 180 mg, 190 mg, 200 mg, 기타 등등. 예를 들어, 정밀 로드는 적어도 30 mg의 아나타빈을 함유할 수 있고 위에 열거된 임의의 다른 성분을 함유하지 않을 수 있거나, 적어도 10 mg의 니코틴, 적어도 10 mg의 THCA 및 적어도 10 mg의 CBGVA를 함유할 수도 있다. 정밀 로드는 하나 보다 많은 알칼로이드, 화합물 또는 첨가제를 함유할 수 있다. 일부 예시적인 실시예에서, 세 가지 유형의 정밀 로드 각각은 전술한 하나 이상의 화합물 중 어느 하나를 포함하거나 포함하지 않고, 전술한 양 중 어느 하나, 즉 적어도 0.10 mg 내지 적어도 200 mg의 종래의 담배, 저 니코틴 담배, 종래의 대마(즉, 마리화나) 및/또는 초저 THC 대마를 더 포함할 수 있다.Each precision rod, regardless of any of the three types, contains nicotine, anatabine, anabasin, flavor,

9-tetrahydrocannabinolic acid (

9-tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA), cannabichromenenic acid (CBCA), cannabigerolic acid (CBGA), tetrahydrocanabivarinic acid (THCVA) , cannabidivarinic acid (CBDVA), cannabichromevarinic acid (CBCVA), cannabigerovarinic acid (CBGVA), myrcene, caryophyllene, pinene ), at least one compound selected from the group consisting of limonene and humulene. Each of the three types of precision rods may contain one or more of the aforementioned compounds in at least the following amounts: 0.10 mg, 0.20 mg, 0.30 mg, 0.40 mg, 0.50 mg, 0.60 mg, 0.70 mg, 0.80 mg, 0.90 mg. mg, 1.0 mg, 1.1 mg, 1.2 mg, 1.3 mg, 1.4 mg, 1.5 mg, 1.6 mg, 1.7 mg, 1.8 mg, 1.9 mg, 2 mg, 3 mg, 4 mg, 5 mg, 6 mg, 7 mg, 8 mg, 9 mg, 10 mg, 11 mg, 12 mg, 13 mg, 14 mg, 15 mg, 16 mg, 17 mg, 18 mg, 19 mg, 20 mg, 21 mg, 22 mg, 23 mg, 24 mg , 25 mg, 26 mg, 27 mg, 28 mg, 29 mg, 30 mg, 31 mg, 32 mg, 33 mg, 34 mg, 35 mg, 36 mg, 37 mg, 38 mg, 39 mg, 40 mg, 41 mg, 42 mg, 43 mg, 44 mg, 45 mg, 46 mg, 47 mg, 48 mg, 49 mg, 50 mg, 51 mg, 52 mg, 53 mg, 54 mg, 55 mg, 56 mg, 57 mg, 58 mg, 59 mg, 60 mg, 61 mg, 62 mg, 63 mg, 64 mg, 65 mg, 66 mg, 67 mg, 68 mg, 69 mg, 70 mg, 71 mg, 72 mg, 73 mg, 74 mg , 75 mg, 76 mg, 77 mg, 78 mg, 79 mg, 80 mg, 81 mg, 82 mg, 83 mg, 84 mg, 85 mg, 86 mg, 87 mg, 88 mg, 89 mg, 90 mg, 91 mg, 92 mg, 93 mg, 94 mg, 95 mg, 96 mg, 97 mg, 98 mg, 99 mg, 100 mg, 110 mg, 120 mg, 130 mg, 140 mg, 150 mg, 160 mg, 170 mg, 180 mg, 190 mg, 200 mg, etc. For example, a precision rod may contain at least 30 mg of anatabine and no other ingredients listed above, or may contain at least 10 mg of nicotine, at least 10 mg of THCA and at least 10 mg of CBGVA. may contain. A precision rod may contain more than one alkaloid, compound or additive. In some exemplary embodiments, each of the three types of precision rods, with or without any one of the one or more compounds described above, is in any one of the above amounts, i.e., from at least 0.10 mg to at least 200 mg of conventional tobacco; It may further include low nicotine cigarettes, conventional cannabis (ie, marijuana) and/or ultra low THC cannabis.

In another illustrative embodiment, the precision rod comprises an amount (ie, at least 0.10 mg to at least 200 mg) of nicotine, anatabine or anabasin not extracted from the Nicotiana plant; i.e., synthesized nicotine, anatabine, or anabasin, which may include the above amounts (i.e., from at least 0.10 mg to at least 200 mg) of one or more of the following cannabinoid acids: synthesized, i.e. , THCA, CBDA, CBCA, CBGA, CBGVA, THCVA, CBDVA and CBCVA, produced outside the hemp plant. For example, a precision rod can contain 30 mg THCA and no other ingredients listed above, or it can contain 10 mg nicotine, 10 mg THCA and 10 mg CBCA. . Precision rods may also contain one or more alkaloids, flavors or other additives.

The precision rod can be of any shape or length and can vary in part depending on the amount of flavor, alkaloid, cannabinoid and/or other additive desired to be delivered to the mainstream smoke. An elongated shape with a pointed end is generally preferred for ease of insertion into smoking articles such as cigars. A precision rod can be prepared, for example, that is 'pure' CBD and contains sugar-like CBDA crystals (eg, 20 mg). Crystalline CBDA or any other crystalline cannabinoid can be prepared by various purification procedures known in the art, for example, by supercritical CO extraction followed by ethanol precipitation to remove residual impurities until the CBDA is approximately 99% pure. It can be provided by any method. The formulation can then be ground to a size of about 100 μm or greater, blended with other compounds or ingredients, and then incorporated into precision rods. These precision rods can be used by smokers transitioning to e-cigarettes or tobacco heating products, or using ultra-low nicotine cigarettes to completely quit tobacco and nicotine products; The method and product are disclosed in US patent application Ser. No. 16/047,948. A precision rod may contain flavors, alkaloids, cannabinoids and/or other additives, or any combination of ingredients. For example, and for recreational purposes, a precision rod may contain 10 mg nicotine, 10 mg CBDA crystals, 20 mg THCA crystals, and 10 mg menthol crystals.

Any onsert, insert, or precision rod disclosed herein can be used in a make-your-own (MYO) cigarette in which an auxiliary nicotine source can be placed inside an empty tobacco tube prior to filling the tube with tobacco, and a supplemental nicotine source prior to rolling the cigarette. can be applied to any type of cigarette, including a direct roll to smoke (RYO) cigarette that can be placed inside a flat rolling paper. Otherwise, onserts, inserts, or precision rods may be used with MYO and RYO cigarettes (already filled with tobacco) similar to methods used with factory manufactured cigarettes. Any onsert, insert, or precision rod disclosed herein may be used in any other type of smoking product, such as a cigar or marijuana smoking product (e.g., joint), whether such smoking products are factory-made or hand-made by consumers. It can be applied to smoking products. For example, after removing some tobacco from the cigarette end of a factory cigarette, an onsert or precision rod can be placed into the cigarette end, and the portion of the removed cigarette can be placed back into the cigarette prior to lighting the cigarette. there is.

Example 3

Precision pods for vaporizers and smoking products

Tobacco and cannabis users can consume solid or semi-solid forms of nicotine and cannabinoids, such as one or more crystalline cannabinoids, together with one or more crystalline alkaloids (with or without terpenes, flavors and other additives, or botanicals), including product devices and formulations. It lacks the ability to conveniently vape or smoke in accurately quantified amounts. Ready-to-vape or ready-to-smoking precision pods are configured for use with vaporizers, pipes, wands, bowls, etc., for the purpose of conveniently vaping or smoking an accurate pre-measured and blended amount of one or more compounds, wherein the precision pod includes such as cannabinoids and alkaloids, both of which cannabinoids and alkaloids are in solid or semi-solid form. In some exemplary embodiments, a precise formulation of blended crystalline cannabinoid acid(s) and crystalline nicoting salt(s) of nicotine is provided in a precision pod. Precision pods are advantageous in many ways, especially for those who smoke or vape both cigarettes and hemp at the same time, or who do not necessarily smoke or vape both cigarettes and hemp at the same time but are dual users of cigarettes and hemp.

From a hazard reduction standpoint, vaping crystalline cannabinoid acid(s) and crystalline nicotine salts in ready-to-vape precision pods is less likely than vaping marijuana buds and cigarettes together or vaping e-cigarettes and marijuana buds individually. Harmful. In an exemplary precision pod embodiment for a vaporizer, vaping tobacco and hemp together or separately is preferred because the active ingredient is much more concentrated in a solid or semi-solid form (eg, a crystalline compound) contained in the precision pod. In comparison, less vapors must be inhaled for a given dose of nicotine or cannabinoids in solid or semi-solid form. For example, e-liquids in e-cigarettes contain less than 6% nicotine (greater than about 95% inactive ingredients), and e-liquids in medical vaping pens typically contain less than 50% cannabinoids that are not crystalline. do. In contrast, precision pods do not contain any carriers such as propylene glycol or glycerin, or contain just enough (about 10 to about 17%) to mimic the moisture levels found in tobacco products or hemp buds. As a result, ready-to-vape crystalline blends of compounds in precision pods are less harmful to the lungs because the active ingredients are so much more concentrated that there are fewer vapors to inhale for a given dose of nicotine or cannabinoid. am.

Propylene glycol and vegetable glycerin are generally recognized and designated as safe (GRAS) by the FDA for ingestion but not inhalation as food additives; Although using e-cigarettes is widely believed to be less harmful than smoking cigarettes (because smoke is produced and not inhaled), there are insufficient long-term data on inhaling large amounts of propylene glycol or vegetable glycerin from e-cigarettes. High purity crystalline nicotine salts with blends of crystalline cannabinoid acid formulations, for example, containing no propylene glycol or glycerin, or containing low amounts of these carriers (e.g., 5 to 15% by weight of the total blend in a precision pod). Vaping may include vaping an e-liquid containing very large proportions of propylene glycol and/or glycerin (e.g., 90%), or vaping whole cannabis flowers, or a less concentrated form of cannabinoids. Compared to pinging, it produces less mainstream vapour, which is less harmful to the lungs.

Similarly, for those who prefer smoking rather than vaping, ready-to-smoking precision pods allow smokers to inhale fumes from cannabinoids and nicotine in their very pure form. Solid or semi-solid crystalline cannabinoid acids (e.g., CBDA and/or THCA) and nicotine salts (with or without terpenes, flavors, and/or other additives) contained in a compartment of a precision pod and smoked in a pipe or bowl. A ready-to-move precision pod containing a blend of Cannabinoids results in a significant reduction in the smoke produced and inhaled for a given level of cannabinoids and a given level of nicotine, compared to blunt, spliff, or factory-manufactured cigarettes containing cannabinoids. causes Since the dose of tobacco-related diseases depends on the cumulative level of tobacco smoke, reducing smoke inhalation reduces harm. In fact, the more non-tobacco substances (e.g., cannabinoids) are in the filler of a conventional factory-manufactured cigarette, the larger the smoker puffs per cigarette, the more puffs, or the more cigarettes per day. are more likely to compensate for reduced nicotine levels, including Conventional cigarettes that contain any significant portion of the cannabinoids in the filler may actually increase harm to the smoker because that portion of the cigarette, and thus nicotine, is being reduced. By replacing 80-90% of the cigarette with cannabinoids, it would be impossible to reduce the nicotine level of a conventional cigarette to the level of an ultra-low nicotine cigarette where compensation would not occur, at which point the cigarette would cease to function.

The ready-to-smoke precision pods allow smokers to achieve the same nicotine satisfaction with significantly less smoke and, importantly, reduce tobacco-specific carcinogenicity resulting from smoking blunt, spiff, or factory-manufactured cigarettes containing cannabinoids. Free from nitrosamines (TSNA) and other tobacco-related compounds. When a synthetic form of nicotine is used, the precision pod is 100% smokeless. In addition to being less harmful by reducing cigarette smoke exposure, compared to blunts, spiffs or other smoking products such as factory-made cigarettes containing cannabinoids, ready-to-smoke precision pods made of crystalline THCA/THC can produce a given level of compounded compounds. and ratio, since the formulation is consistent because of its level of purity. Ingredients such as flavors, terpenes and other additives, or botanicals (eg, minimal amounts of ultra low THC hemp) may also be incorporated into the precision pod formulations at minimal levels.

As shown in FIG. 3A , the hexagonal prism-shaped precision pod 29 is, within the compartment of the precision pod 29, a nicotine salt (which may include any single or combination of nicotine salts listed above), crystalline It contains a combination of THCA, crystalline CBDA and menthol crystals. Appropriate levels of emollients are added to the formulation to remove smoke and remove harshness, and propylene glycol and/or glycerin are also included to ensure the formulation has adequate moisture levels. About 12 to about 14% is an ideal moisture level for tobacco filler and hemp flowers. The moisture level of the formulation of the ready-to-smoke precision pod depends on many factors, including the boiling point temperature and amount of each compound (and any botanical ingredients) in the formulation, and the boiling point and total amount of the mixture. Different formulations may have different moisture levels. These compounds are formulated together and are in solid or semi-solid form. A precision pod may include two or more vents. The precision pod 29 of FIG. 3A includes multiple vents (only one is labeled). Vents in the precision pod are for venting incoming air into the compartment and outgoing fumes out of the compartment.

9-테트라하이드로카나비놀산(

9-tetrahydrocannabinolic acid, THCA), 카나비디올산(cannabidiolic acid, CBDA), 카나비크로멘산(cannabichromenenic acid, CBCA), 카나비게롤산(cannabigerolic acid, CBGA), 카나비게로바린산(cannabigerovarinic acid, CBGVA), 테트라하이드로카나비바린산(tetrahydrocanabivarinic acid, THCVA), 카나비디바린산(cannabidivarinic acid, CBDVA), 카나비크로메바린산(cannabichromevarinic acid, CBCVA), 미르센(myrcene), 카리오필렌(caryophyllene), 피넨(pinene), 리모넨(limonene) 및/또는 휴뮬렌(humulene)으로 이루어진 군으로부터선택되는 둘 이상의 화합물을 포함할 수 있다. 각각의 즉시 베이핑 가능한 또는 즉시 흡연 가능한 정밀 포드는 적어도 다음의 양의 전술한 화합물 각각을 포함할 수 있다:0.10 mg, 0.20 mg, 0.30 mg, 0.40 mg, 0.50 mg, 0.60 mg, 0.70 mg, 0.80 mg, 0.90 mg, 1.0 mg, 1.1 mg 1.2 mg, 1.3 mg, 1.4 mg, 1.5 mg, 1.6 mg, 1.7 mg, 1.8 mg, 1.9 mg, 2 mg, 3 mg, 4 mg, 5 mg, 6 mg, 7 mg, 8 mg, 9 mg, 10 mg, 11 mg, 12 mg, 13 mg, 14 mg, 15 mg, 16 mg, 17 mg, 18 mg, 19 mg, 20 mg, 21 mg, 22 mg, 23 mg, 24 mg, 25 mg, 26 mg, 27 mg, 28 mg, 29 mg, 30 mg, 31 mg, 32 mg, 33 mg, 34 mg, 35 mg, 36 mg, 37 mg, 38 mg, 39 mg, 40 mg, 41 mg, 42 mg, 43 mg, 44 mg, 45 mg, 46 mg, 47 mg, 48 mg, 49 mg, 50 mg, 51 mg, 52 mg, 53 mg, 54 mg, 55 mg, 56 mg, 57 mg, 58 mg, 59 mg, 60 mg, 61 mg, 62 mg, 63 mg, 64 mg, 65 mg 66 mg, 67 mg, 68 mg, 69 mg, 70 mg, 71 mg, 72 mg, 73 mg, 74 mg, 75 mg 76 mg, 77 mg, 78 mg, 79 mg, 80 mg, 81 mg, 82 mg, 83 mg, 84 mg, 85 mg, 86 mg, 87 mg, 88 mg, 89 mg, 90 mg, 91 mg, 92 mg, 93 mg, 94 mg, 95 mg, 96 mg, 97 mg, 98 mg, 99 mg, 100 mg, 110 mg, 120 mg, 130 mg, 140 mg, 150 mg, 160 mg, 170 mg, 180 mg 190 mg, 200 mg, 250 mg, 300 mg, 기타 등등. 예를 들어, 정밀 포드는 적어도 10 mg의 CBDA, 적어도 5 mg의 니코틴 및 적어도 5 mg의 멘톨을 포함할 수 있다. 미국 특허 출원 번호 16/047,948에 개시된 바와 같이, 금연 치료로서 또는 흡연자를 담배 가열 제품 또는 전자 궐련으로 전환하는 것을 돕기 위해, 즉시 베이핑 가능한 또는 즉시 흡연 가능한 정밀 포드에 대해 상기 언급한 화합물 중 적어도 하나와 함께 임의의 상기 양(즉, 적어도 0.10 mg 내지 적어도 300 mg)의 저 니코틴 담배 및/또는 초저 THC 대마가 정밀 포드에 포함될 수있다. Each ready-to-vap or ready-to-smoke precision pod contains nicotine, anatabine, anabasin, flavor,

9-tetrahydrocannabinolic acid (

9-tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA), cannabichromenenic acid (CBCA), cannabigerolic acid (CBGA), cannabigerovarinic acid (CBGVA), tetrahydrocanabivarinic acid (THCVA), cannabidivarinic acid (CBDVA), cannabichromevarinic acid (CBCVA), myrcene, caryophyllene, pinene ), two or more compounds selected from the group consisting of limonene and/or humulene. Each ready-to-vap or smoke-ready precision pod can contain at least the following amounts of each of the foregoing compounds: 0.10 mg, 0.20 mg, 0.30 mg, 0.40 mg, 0.50 mg, 0.60 mg, 0.70 mg, 0.80 mg. mg, 0.90 mg, 1.0 mg, 1.1 mg 1.2 mg, 1.3 mg, 1.4 mg, 1.5 mg, 1.6 mg, 1.7 mg, 1.8 mg, 1.9 mg, 2 mg, 3 mg, 4 mg, 5 mg, 6 mg, 7 mg, 8 mg, 9 mg, 10 mg, 11 mg, 12 mg, 13 mg, 14 mg, 15 mg, 16 mg, 17 mg, 18 mg, 19 mg, 20 mg, 21 mg, 22 mg, 23 mg, 24 mg, 25 mg, 26 mg, 27 mg, 28 mg, 29 mg, 30 mg, 31 mg, 32 mg, 33 mg, 34 mg, 35 mg, 36 mg, 37 mg, 38 mg, 39 mg, 40 mg , 41 mg, 42 mg, 43 mg, 44 mg, 45 mg, 46 mg, 47 mg, 48 mg, 49 mg, 50 mg, 51 mg, 52 mg, 53 mg, 54 mg, 55 mg, 56 mg, 57 mg, 58 mg, 59 mg, 60 mg, 61 mg, 62 mg, 63 mg, 64 mg, 65 mg 66 mg, 67 mg, 68 mg, 69 mg, 70 mg, 71 mg, 72 mg, 73 mg, 74 mg, 75 mg 76 mg, 77 mg, 78 mg, 79 mg, 80 mg, 81 mg, 82 mg, 83 mg, 84 mg, 85 mg, 86 mg, 87 mg, 88 mg, 89 mg, 90 mg, 91 mg, 92 mg, 93 mg, 94 mg, 95 mg, 96 mg, 97 mg, 98 mg, 99 mg, 100 mg, 110 mg, 120 mg, 130 mg, 140 mg, 150 mg, 160 mg, 170 mg, 180 mg 190 mg, 200 mg, 250 mg, 300 mg, etc. For example, a precision pod can include at least 10 mg of CBDA, at least 5 mg of nicotine and at least 5 mg of menthol. At least one of the above-mentioned compounds for a ready-to-vape or ready-to-smoke precision pod, as disclosed in U.S. Patent Application No. 16/047,948, as a smoking cessation treatment or to help a smoker convert to a tobacco heating product or e-cigarette Any of the above amounts (i.e., from at least 0.10 mg to at least 300 mg) of low nicotine cigarettes and/or ultra low THC cannabis may be included in the precision pod.

In some exemplary embodiments, the precision pods contain any of the foregoing amounts (ie, from at least 0.10 mg to at least 300 mg) of nicotine, anatabine, or anabasin not extracted from the Nicotiana plant; i.e., can contain any of synthetic nicotine, anatabine or anabasin, and the precision pod can contain any of the above amounts (i.e., from at least 0.10 mg to at least 300 mg) of two or more of the following cannabinoid acids: THCA, CBDA, CBCA, CBGA, THCVA, CBDVA, CBCVA and CBGVA synthesized, i.e. produced outside the cannabis plant. In another exemplary embodiment, any of the foregoing amounts (i.e., from at least 0.10 mg to at least 300 mg) of conventional tobacco, low nicotine tobacco, conventional hemp (i.e., marijuana) and/or ultra low THC hemp is any of the following compounds: Can be contained in a ready-to-vap or ready-to-smoke precision pod with at least one of: nicotine, anatabine, anabasin, flavor, THCA, CBDA, CBCA, CBGA, THCVA, CBDVA, CBCVA and CBGVA, myrcene, caryophyllene. , pinene, limonene and/or humulene.

In some exemplary embodiments, the ready-to-vapable or ready-to-smoke precision pods each contain at least 5 mg of tobacco (conventional or ultra-low nicotine) and/or at least 5 mg of hemp (marijuana or ultra-low THC hemp) and at least 2 mg of tobacco (regular or ultra-low nicotine). and the aforementioned compounds, such as THCVA (tetrahydrocanabivaric acid). For ready-to-vap or ready-to-smoke precision pods (and onsert or precision rods) herein, low nicotine cigarettes refer to cigarettes with a nicotine content of 3 mg/g or less, and ultra-low THC hemp refers to cigarettes with a nicotine content of 3 mg/g or less. Means cannabis with an aggregate THCA/THC content of less than g.

Precision pods can be of any size or shape, including those designed for specific models of vaporizers, pipes, bowls or wands. The precision pod is configured for the oven chamber of a vaporizer or the tobacco or hemp chamber of a pipe, bowl or bong. Examples of suitable materials for the rigid precision pod include ceramics, including fused quartz or silica, non-toxic ultra-high temperature ceramics, and any metal and preferably a non-toxic metal or metal alloy such as titanium and food grade stainless steel; However, any material may be used for the precision pod, whether constructed for the vaporizer or pipe, bowl, or wand. The material used for the vaporizer may vary depending on the capacity or temperature range of the vaporizer since different materials, including metals, heat up at different rates. In some exemplary embodiments, the precision pod is configured for a specific model of vaporizer already on the market, or the precision pod and vaporizer are configured for each other during the product development phase of a newly designed vaporizer. In another exemplary embodiment, the generic precision pod is configured for multiple types of smoking articles or multiple types of vaporizers.

For precision pods designed for smoking articles, materials that do not result in burning or partial burning are preferred; Materials that cause burning may also be used and composed of paper-like materials such as reconstituted tobacco or other cellulosic materials such as those produced from hemp. A less rigid precision pod of this type is useful for low doses of compound. Similarly, for precision pods configured for vaporizers, it is preferred that only the contents within the compartment of the precision pod be delivered as mainstream vapor, and not the compounds or components of the precision pod itself. One of the major advantages of disposable ready-to-smoking or ready-to-vape precision pods is the convenience of exact blending of the desired compounds in exact proportions, whether solid or not; However, in another exemplary embodiment, the precision pod may be reusable, in which case it may have an access panel that opens and closes with fasteners to provide access for removing used material and adding fresh compound. The bottom of the precision pod may have legs so that air venting at the bottom of the vaporizer's oven chamber or draft holes in the chamber of the bowl, pipe or rod is not blocked by the bottom of the precision pod. In some exemplary embodiments of the ready-to-vapor precision pod, the vent in the bottom of the precision pod is configured to precisely align with the vent in the bottom of an oven chamber within the vaporizer. In another exemplary embodiment of the smoke ready precision pod, the vent(s) in the bottom of the precision pod are configured to precisely align with the draft holes of the chamber in the bowl, pipe or rod. There may be one or more shelves within the compartment of the precision pod so that compounds and any ingredients do not rest on the bottom of the compartment. This depends on the types of compounds in the precision pods and their boiling points, the total amount of compounds in the precision pods, whether any plant material is present in the precision pods, and whether the precision pods are specifically formulated for a particular model of vaporizer or smoking article. Depends.

As shown in FIG. 3B, a ready-to-smoking precision pod 31 is placed in a bowl 32 and may be used with other smoking articles such as pipes or wands. The precision pod contains the desired compounds and precise blends of ingredients, and allows the blends within the compartments of the precision pod to be heated, melted, and burned uniformly. A precise combination of crystalline nicotine, crystalline cannabinoid acids (e.g., THCA and CBDA), menthol, and an emollient can provide a given dose of nicotine compared to smoking, for example, a splip, bluff, or factory-manufactured cigarette containing cannabinoids. Or dramatically reduce the amount of smoke inhaled for a given dose of cannabinoid. This is due to the higher concentration of nicotine in these formulations, which causes the smoker to compensate (ie titrate). Because some embodiments of ready-to-smoke precision pods do not contain cannabis plant material (other than crystalline cannabinoids) or tobacco plant material (other than crystalline nicotine salts), less smoke and 'tar' are produced and inhaled less. produce harmful products. In another exemplary embodiment, the precision pod does not contain any compounds or ingredients extracted or derived from tobacco; However, they contain synthetic nicotine which results in a tobacco-free and nicotine-free precision pod formulation.

As shown in FIG. 3C , the vaporizer 33 is held and the oven cover 34 is removed from the top of the vaporizer 33 . The oven chamber 35 is exposed, in which case ready-to-vape precision pods may be positioned so that an accurate amount of one or more compounds or two or more compounds plus plant material(s), such as hemp, can be vape. . As shown in FIG. 3D , the vaporizer 33 now includes an exemplary embodiment of a ready-to-vape precision pod 36 placed within the oven chamber 35 of the vaporizer. Ready-to-vape precision pods contain precise compound formulations in compartments, and precision pods are ready to use right out of the package. Four legs 37 are included on the precision pod to increase air and vapor flow at the bottom of the precision pod. When the vaporizer is powered on, the oven chamber 35 is heated and contains at least 5 mg of a crystalline salt of nicotine, at least 5 mg of crystalline cannabidiolic acid (CBDA) and an emollient (e.g., to smooth the vapor and reduce harshness). Heat the contents of the precision pod, including one or more food grade acids such as citric acid to remove). These solid or semi-solid formulations do not contain or deliver carcinogenic tobacco compounds such as TSNA into mainstream vapors. The ready-to-vape precision pod 36 of FIG. 3D reduces alcohol vapor exposure compared to vaping nicotine containing e-cigarettes, since the concentration of nicotine in the liquor vapor of the precision pod is much higher than that of the e-liquid. Therefore, vapers of precision pods compensate by inhaling less vapor accordingly. Similarly, there is also a higher concentration of nicotine in the liquor vapor from precision pods compared to tobacco heated products, so less liquor vapor needs to be inhaled per mg of desired nicotine, which means that the precision pod does not contain tobacco. This provides the added advantage that mainstream vapors from precision pods do not contain tobacco carcinogens.

Of course, each of the three products, namely the ready-to-vape precision pod, the e-cigarette, and the tobacco heating product, when compared to a combustible cigarette (with or without added cannabinoids), results in reduced harm, which is why these three products Because there is no burning, there is no tobacco smoke, which contains thousands of compounds, including dozens of carcinogens. Another side benefit of the ready-to-vape precision pod is that the vaporizer can keep the vaporizer cleaner compared to not using the precision pod, as much of the remaining spent substance is retained within the precision pod and , because it seeps into the vents at the bottom of the oven chamber of the vaporizer, requiring the vaporizer to be cleaned less frequently.

In some demonstrative embodiments, the precision pod comprises at least 5 mg of low nicotine cigarettes and/or at least 5 mg of ultra low THC hemp, allowing smokers to completely quit cigarettes and nicotine products or to use e-cigarettes, tobacco heating products, or precision pods. Helps switch to less harmful products such as See U.S. Patent Application Serial No. 16/047,948 for methods of converting conventional cigarette smokers to less harmful products and various types of products. The precision pods containing low nicotine cigarettes and/or ultra low THC hemp contain THCA, CBDA, CBCA, CBGA, THCVA, CBDVA, CBCVA, CBGVA, nicotine, anatabine, anabasin, myrcene, caryophyllene, pinene, limonene and It may further include at least 2 mg of one or more compounds selected from the group consisting of humulene. For example, a precision pod comprising at least 50 mg of low nicotine cigarettes, at least 50 mg of ultra-low THC hemp, and at least 5 mg of CBDA provides significantly less smoke exposure than an ultra-low nicotine cigarette comprising about 600 mg of low nicotine cigarettes. causes

9-테트라하이드로카나비놀산(THCA)을 포함하는, 결정질 또는 거의 결정질 카나비노이드 산의 배합물, 및 (테르펜, 향미, 및/또는 다른 첨가제, 또는 식물 성분과 같은 성분을 포함하거나 포함하지 않는) 결정질 또는 근결정질 니코틴 염(들)은, 담배 독소에 대한 노출 및 편의 측면에서 담배 및 오락성 마리화나의 이중 사용자에게 유리하다. 카나비디올산(CBDA)을 포함하여, 결정질 또는 거의 결정질 카나비노이드 산의 배합물을 포함하는, 즉시 베이핑 가능한 정밀 포드는, 통증 완화를 추구하고 베이핑 펜으로부터 부피가 큰 증기를 흡입하고 싶지 않은 사람들에게 유리하다.For formulations of precision pods containing intoxicating compounds such as THCA/THC, the type and magnitude of intoxicating effects can be predicted by using precision pods with accurately quantified, ready-to-vape or ready-to-smoke formulations. for example,

Blends of crystalline or nearly crystalline cannabinoid acids, including 9-tetrahydrocannabinolic acid (THCA), and crystalline or nearly crystalline (with or without ingredients such as terpenes, flavors, and/or other additives, or botanicals) The near-crystalline nicotine salt(s) are beneficial to dual users of tobacco and recreational marijuana in terms of convenience and exposure to tobacco toxins. Ready-to-vape precision pods containing a blend of crystalline or near-crystalline cannabinoid acids, including cannabidiolic acid (CBDA), are ideal for those seeking pain relief and not wanting to inhale bulky vapors from a vaping pen. It is advantageous.

As the potency of cannabis concentrates increases, precise dosing becomes increasingly difficult, and THC effects can be quite variable. Consuming cannabis concentrates, such as crystalline cannabinoids, waxes, budders, oils, flyaways or sap, is usually achieved by 'dabbing', which is accomplished by an extremely hot metal object such as a nail heated by a torch or the like. It is to place the concentrate on and then inhale the vapor. In addition to being a risky and cumbersome procedure, obtaining the correct amount of concentrate is extremely difficult and often results in overconsumption and unpleasant effects. The potential safety issues and potential toxic effects of THC mixtures are often unknown, and actual toxic effects can vary widely from batch to batch of cannabis concentrate production. THC ratios may be unknown or imprecise, and the 'entourage effect' due to the interaction of various cannabinoids and impurities is difficult to predict. These disadvantages also occur in concentrates used in vaporizers.

Compared to dabbing, an advantage of ready-to-smoke and ready-to-vappable precision pods containing one or more crystalline cannabinoid acids is that each of the one or more crystalline cannabinoid acids is a cannabinoid acid that is ready to smoke or vape without preparation. (up to approximately 99% purity), and the precision pods provide virtually consistent effects for the same person. In some exemplary embodiments of the precision pod, the foregoing amount of THCA in milligrams, together with the purity level of the THCA (THCA weight divided by the total weight of the compound and any additives or ingredients in the precision pod), is at least about 80%. %, at least about 85%, at least about 90%, at least about 93%, at least about 95%, at least about 97%, at least about 98%, or at least about 99%; This should give you an idea of what effect to expect for the THCA content and THCA percentage of the formulation. For example, the effect of a precision pod comprising 5 mg nicotine salt, 50 mg crystalline THCA and 20 mg crystalline CBDA, 17.5 mg ultra low THC hemp (>0.30% THCA) and 7.5 mg carrier and/or emollient. The predictability and consistency of Cannabis is very beneficial to cannabis users who want precise, robust and consistent effects with simultaneous THC/nicotine effects. The THC purity level for this 100 mg precision pod formulation is 50% (50 mg/100 mg). The nicotine/THC ratio is 10% and the CBD/THC ratio is 40%. Compared to dabbing or vaping other concentrates in which the cannabinoid percentage and THC level are not known or inconsistent in all production batches, ready-to-vapable and ready-to-smokable precision pods containing crystalline cannabinoids want consistency in the concentrate. and beneficial for cannabis users who do not want to consume too much THC at once. The purity of precisely measured amounts and proportions of crystalline cannabinoids and crystalline nicotine forms combined with precision pods not only results in consistency and harm reduction, but also the convenience of ready-to-smokable and ready-to-vape precision pods are suitable for use with many vaping devices. Or, it is advantageous compared to using it.

The advantages of precision pods are readily apparent in overcoming biological constraints on the cannabis plant, which inherently produces a small number of specific cannabinoids and a specific proportion of cannabinoids. For example, tetrahydrocannabivaric acid (THCVA), which decarboxylates to tetrahydrocanabivarin (THCV), is a minor cannabinoid found at trace levels in most cannabis strains. Sativa strains tend to have higher THCVA content. THCV is an important appetite suppressant, a therapeutic for reducing panic attacks, and may be a therapeutic for the treatment of nicotine dependence and possibly other types of dependence. Since THCV is a minor cannabinoid, it would be very difficult, if not impossible, to vape or smoke flowers from the cannabis strain that contain a THCVA to THCA ratio of at least 3/2 or a THCVA to CBDA ratio of at least 3/2. In some exemplary embodiments, THCVA is extracted and isolated for use in a precision pod (or onsert or precision rod) comprising a THCVA to THCA ratio of at least 3/2. In another exemplary embodiment, THCVA is extracted and isolated for use in a precision pod (or onsert or precision rod) comprising a THCVA to CBDA ratio of at least 3/2. Tetrahydrocanabivaric acid (THCVA) can be synthesized and used in precision pods, precision rods and onserts.

It will be appreciated that any exemplary embodiment of the present disclosure may be automated with a machine, whether a pure machine, a tabletop machine, or a more substantial electrical type of machine. For example, in some exemplary embodiments, the machine may provide a secondary nicotine source (eg, precision rod) to multiple cigarettes at once, such as a full pack of 20 cigarettes.

Certain precision rods, onserts, ready-to-vape precision pods and ready-to-smoke precision pods containing crystalline alkaloids may not be considered tobacco products in some jurisdictions because, among other reasons, they are derived from the tobacco plant. This is because it does not contain tobacco other than alkaloids, which may or may not be. The alkaloids of these products can be synthesized so that none of the components are derived from the tobacco plant. Likewise, in some exemplary embodiments, the cannabinoids used in the onsert, precision rod, or precision pod may be synthesized and produced external to the cannabis plant. In another exemplary embodiment, a synthetic alkaloid and a synthetic cannabinoid are combined to create a formulation for use in an onsert, precision rod, or precision pod that does not contain any Nicotiana or cannabis plant material.

Claims (60)

A disposable, ready-to-vape precision pod for use with a vaporizer as a smoking cessation treatment to assist a smoker in transitioning to an e-cigarette or tobacco heating product, or to completely quit tobacco and nicotine products, the ready-to-vape precision pod comprising: :
nicotine, anatabine, anabasin, flavoring agents,

9-tetrahydrocannabinolic acid (

9-tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA), cannabichromenenic acid (CBCA), cannabigerolic acid (CBGA), cannabigerovarinic acid (CBGVA), tetrahydrocanabivarinic acid (THCVA), cannabidivarinic acid (CBDVA), cannabichromevarinic acid (CBCVA), myrcene, caryophyllene, pinene ), at least 2 mg of one or more compounds selected from the group consisting of limonene and humulene;
at least 5 mg of THC hemp;
at least 5 mg of nicotine cigarettes;
a compartment accommodating the one or more compounds, the THC hemp, and the nicotine cigarette; and
one or more vents for venting air and vapor into and out of the compartment;
wherein the ready-to-vappable precision pod is configured for an oven chamber of the vaporizer to be placed into the oven chamber;
wherein said at least 5 mg of THC hemp comprises a combined THCA/THC content of less than or equal to 3 mg/g, and
wherein the at least 5 mg of nicotine tobacco comprises a nicotine content of 3 mg/g or less. According to claim 1,
The ready-to-vape precision pod, wherein the one or more compounds is a flavoring agent comprising menthol. According to claim 1,
The ready-to-vape precision pod, wherein the at least one compound is tetrahydrocanabivaric acid (THCVA). According to claim 1,
The ready-to-vape precision pod, wherein the at least one compound is anatabine. According to claim 1,
The ready-to-vape precision pod, wherein the at least one compound is cannabidiolic acid (CBDA). According to claim 5,
A ready-to-vape precision pod further comprising at least 2 mg of citicnicline. For use with vaporizers configured to produce vapor from dried herbal or plant extracts, to assist cigarette smokers transition to e-cigarettes or tobacco heating products, for use as a smoking cessation remedy, or to completely quit tobacco and nicotine products An ready-to-vape precision pod for doing, the ready-to-vape precision pod:
nicotine, anatabine, anabasin, flavoring agents,

9-tetrahydrocannabinolic acid/

9-tetrahydrocannabinol (THCA/THC), cannabidiolic acid/cannabidiol (CBDA/CBD), cannabichromenic acid/cannabichromene (CBCA/CBC), cannabigerolic acid/cannabigerol (CBGA) /CBG), tetrahydrocanabivaric acid/tetrahydrocannabivarin (THCVA/THCV), cannabidivaric acid/cannabidivarin (CBDVA/CBDV), canabichromevaric acid/cannabichromevarin (CBCVA/ CBCV), cannabigerovaric acid/cannabigerivarin (CBGVA/CBGV), myrcene, caryophyllene, pinene, limonene and humulene selected from the group consisting of , at least 2 mg of one or more compounds;
at least 5 mg of THC hemp;
at least 5 mg of nicotine cigarettes;
a compartment accommodating the one or more compounds, the THC hemp, and the nicotine cigarette; and
one or more vents for venting air and vapor into and out of the compartment;
wherein said at least 5 mg of THC hemp comprises a combined THCA/THC content of less than or equal to 3 mg/g, and
wherein the at least 5 mg of nicotine tobacco comprises a nicotine content of 3 mg/g or less. According to claim 7,
The ready-to-vape precision pod, wherein the at least one compound is anatabine. According to claim 7,
wherein the at least one compound is anabacin. According to claim 7,
The ready-to-vape precision pod, wherein the at least one compound is CBCA/CBC. According to claim 7,
The ready-to-vape precision pod, wherein the at least one compound is CBCVA/CBCV. According to claim 7,
The ready-to-vape precision pod, wherein the at least one compound is CBDA/CBD. According to claim 7,
The ready-to-vape precision pod, wherein the at least one compound is CBDVA/CBDV. According to claim 7,
wherein the at least one compound is CBGA/CBG. According to claim 7,
The ready-to-vape precision pod, wherein the at least one compound is CBGVA/CBGV. According to claim 7,
wherein the at least one compound is THCVA/THCV. According to claim 7,
The ready-to-vape precision pod, wherein the one or more compounds is a flavoring agent comprising menthol. For use with vaporizers configured to produce vapor from dried herbal or plant extracts, to assist cigarette smokers transition to e-cigarettes or tobacco heating products, for use as a smoking cessation remedy, or to completely quit tobacco and nicotine products An ready-to-vape precision pod for doing, the ready-to-vape precision pod:
nicotine, anatabine, anabasin, flavoring agents,

9-tetrahydrocannabinolic acid/

9-tetrahydrocannabinol (THCA/THC), cannabidiolic acid/cannabidiol (CBDA/CBD), cannabichromenic acid/cannabichromene (CBCA/CBC), cannabigerolic acid/cannabigerol (CBGA) /CBG), tetrahydrocanabivaric acid/tetrahydrocannabivarin (THCVA/THCV), cannabidivaric acid/cannabidivarin (CBDVA/CBDV), canabichromevaric acid/cannabichromevarin (CBCVA/ CBCV), cannabigerovaric acid/cannabigerivarin (CBGVA/CBGV), myrcene, caryophyllene, pinene, limonene and humulene selected from the group consisting of , at least 2 mg of one or more compounds;
at least 5 mg of hemp;
at least 5 mg of nicotine cigarettes;
a compartment accommodating the one or more compounds, the cannabis, and the nicotine tobacco; and
one or more vents for venting air and vapor into and out of the compartment;
wherein the at least 5 mg of nicotine tobacco comprises a nicotine content of 3 mg/g or less. According to claim 18,
The ready-to-vape precision pod, wherein the at least one compound is anatabine. According to claim 18,
wherein the at least one compound is anabacin. According to claim 18,
The ready-to-vape precision pod, wherein the one or more compounds is a flavoring agent comprising menthol. As a smoking cessation treatment, as a smokeable precision pod for use with a smoking product for mainstream smoke inhalation, to assist a smoker in transitioning to an e-cigarette or tobacco heating product, or to completely quit tobacco and nicotine products, said immediate Smokeable precision pods are:
nicotine, anatabine, anabasin, flavoring agents,

9-tetrahydrocannabinolic acid/

9-tetrahydrocannabinol (THCA/THC), cannabidiolic acid/cannabidiol (CBDA/CBD), cannabichromenic acid/cannabichromene (CBCA/CBC), cannabigerolic acid/cannabigerol (CBGA) /CBG), tetrahydrocanabivaric acid/tetrahydrocannabivarin (THCVA/THCV), cannabidivaric acid/cannabidivarin (CBDVA/CBDV), canabichromevaric acid/cannabichromevarin (CBCVA/ CBCV), cannabigerovaric acid/cannabigerivarin (CBGVA/CBGV), myrcene, caryophyllene, pinene, limonene and humulene selected from the group consisting of , at least 2 mg of one or more compounds;
at least 5 mg of nicotine cigarettes;
at least 5 mg of THC hemp;
a compartment accommodating the one or more compounds, the nicotine tobacco, and the THC hemp; and
one or more vents for venting air and smoke into and out of the compartment;
wherein the smoking article comprises a pipe, bowl or bong;
wherein the smokeable precision pod is configured for a tobacco or hemp chamber of a pipe, bowl or bong;
wherein said at least 5 mg of THC hemp comprises a combined THCA/THC content of less than or equal to 3 mg/g, and
wherein the at least 5 mg nicotine cigarette comprises a nicotine content of 3 mg/g or less. The method of claim 22,
wherein the at least one compound is anabacin. The method of claim 22,
wherein the at least one compound is anatabine. The method of claim 22,
wherein the one or more compounds is a flavoring agent comprising menthol. The method of claim 22,
wherein the at least one compound is THCVA/THCV. The method of claim 22,
wherein the at least one compound is CBDA/CBD. delete delete delete delete delete delete delete delete delete delete delete delete delete delete delete delete delete delete delete delete delete delete delete delete delete delete delete delete delete delete delete delete delete

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