NZ786360A - Phospholipid ether conjugates as cancer-targeting drug vehicles - Google Patents
Phospholipid ether conjugates as cancer-targeting drug vehiclesInfo
- Publication number
- NZ786360A NZ786360A NZ786360A NZ78636020A NZ786360A NZ 786360 A NZ786360 A NZ 786360A NZ 786360 A NZ786360 A NZ 786360A NZ 78636020 A NZ78636020 A NZ 78636020A NZ 786360 A NZ786360 A NZ 786360A
- Authority
- NZ
- New Zealand
- Prior art keywords
- cancer
- targeting drug
- phospholipid ether
- drug vehicles
- therapeutic compounds
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/688—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols both hydroxy compounds having nitrogen atoms, e.g. sphingomyelins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
- A61K47/544—Phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/60—Quinoline or hydrogenated quinoline ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
- C07F9/65517—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring condensed with carbocyclic rings or carbocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962899615P | 2019-09-12 | 2019-09-12 | |
| US201962899611P | 2019-09-12 | 2019-09-12 | |
| US201962899618P | 2019-09-12 | 2019-09-12 | |
| US201962946870P | 2019-12-11 | 2019-12-11 | |
| US202062956844P | 2020-01-03 | 2020-01-03 | |
| US202062956907P | 2020-01-03 | 2020-01-03 | |
| PCT/US2020/050459 WO2021050917A1 (en) | 2019-09-12 | 2020-09-11 | Phospholipid ether conjugates as cancer-targeting drug vehicles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ786360A true NZ786360A (en) | 2025-12-19 |
Family
ID=74866023
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ786360A NZ786360A (en) | 2019-09-12 | 2020-09-11 | Phospholipid ether conjugates as cancer-targeting drug vehicles |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20230066517A1 (https=) |
| EP (1) | EP4028018A4 (https=) |
| JP (3) | JP7749542B2 (https=) |
| KR (1) | KR20220062363A (https=) |
| CN (1) | CN114599371A (https=) |
| AU (1) | AU2020346898B2 (https=) |
| BR (1) | BR112022004482A2 (https=) |
| CA (1) | CA3150991A1 (https=) |
| IL (1) | IL291197A (https=) |
| MX (1) | MX2022003044A (https=) |
| NZ (1) | NZ786360A (https=) |
| WO (1) | WO2021050917A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3095515A1 (en) * | 2018-04-10 | 2019-10-17 | Cellectar Biosciences, Inc. | Phospholipid-flavagline conjugates and methods of using the same for targeted cancer therapy |
| NZ786360A (en) * | 2019-09-12 | 2025-12-19 | Cellectar Biosciences Inc | Phospholipid ether conjugates as cancer-targeting drug vehicles |
| BR112022006739B1 (pt) * | 2019-10-10 | 2024-01-23 | Cellectar Biosciences, Inc | Conjugados fosfolipídio-flavagina e métodos de uso do mesmo para terapia direcionada a câncer |
| CN113816990B (zh) * | 2021-03-22 | 2023-08-22 | 联宁（苏州）生物制药有限公司 | 修饰的氨基酸及其在adc中的应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8540968B2 (en) * | 2004-03-02 | 2013-09-24 | Cellectar, Inc. | Phospholipid ether analogs as agents for detecting and locating cancer, and methods thereof |
| WO2011031919A2 (en) * | 2009-09-11 | 2011-03-17 | Cellectar, Inc. | Non-radioactive phospholipid compounds, compositions, and methods of use |
| CA2968145C (en) | 2014-11-17 | 2023-06-27 | Cellectar Biosciences, Inc. | Phospholipid ether analogs as cancer-targeting drug vehicles |
| EP3439666A4 (en) | 2016-05-20 | 2019-12-11 | The University of Chicago | NANOPARTICLES FOR CHEMOTHERAPY, TARGETED THERAPY, PHOTODYNAMIC THERAPY, IMMUNOTHERAPY AND ALL COMBINATIONS THEREOF |
| WO2017218702A1 (en) * | 2016-06-14 | 2017-12-21 | Cellectar Biosciences, Inc. | Phospholipid ether analogs for the identification and isolation of circulating tumor cells |
| CA3095515A1 (en) | 2018-04-10 | 2019-10-17 | Cellectar Biosciences, Inc. | Phospholipid-flavagline conjugates and methods of using the same for targeted cancer therapy |
| NZ786360A (en) * | 2019-09-12 | 2025-12-19 | Cellectar Biosciences Inc | Phospholipid ether conjugates as cancer-targeting drug vehicles |
-
2020
- 2020-09-11 NZ NZ786360A patent/NZ786360A/en unknown
- 2020-09-11 CA CA3150991A patent/CA3150991A1/en active Pending
- 2020-09-11 US US17/642,561 patent/US20230066517A1/en active Pending
- 2020-09-11 CN CN202080074564.3A patent/CN114599371A/zh active Pending
- 2020-09-11 WO PCT/US2020/050459 patent/WO2021050917A1/en not_active Ceased
- 2020-09-11 KR KR1020227011911A patent/KR20220062363A/ko active Pending
- 2020-09-11 EP EP20862948.5A patent/EP4028018A4/en active Pending
- 2020-09-11 MX MX2022003044A patent/MX2022003044A/es unknown
- 2020-09-11 BR BR112022004482A patent/BR112022004482A2/pt unknown
- 2020-09-11 JP JP2022516159A patent/JP7749542B2/ja active Active
- 2020-09-11 AU AU2020346898A patent/AU2020346898B2/en active Active
-
2022
- 2022-03-08 IL IL291197A patent/IL291197A/en unknown
-
2025
- 2025-02-13 JP JP2025021639A patent/JP2025087716A/ja active Pending
- 2025-06-30 JP JP2025110172A patent/JP2025138792A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| MX2022003044A (es) | 2022-06-02 |
| WO2021050917A1 (en) | 2021-03-18 |
| EP4028018A4 (en) | 2023-10-11 |
| CN114599371A (zh) | 2022-06-07 |
| JP7749542B2 (ja) | 2025-10-06 |
| KR20220062363A (ko) | 2022-05-16 |
| JP2025138792A (ja) | 2025-09-25 |
| IL291197A (en) | 2022-05-01 |
| JP2022547331A (ja) | 2022-11-11 |
| AU2020346898A1 (en) | 2022-04-07 |
| AU2020346898B2 (en) | 2026-04-09 |
| BR112022004482A2 (pt) | 2022-05-31 |
| JP2025087716A (ja) | 2025-06-10 |
| EP4028018A1 (en) | 2022-07-20 |
| CA3150991A1 (en) | 2021-03-18 |
| US20230066517A1 (en) | 2023-03-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PSEA | Patent sealed |