NZ724357B2 - Cosmetic composition for skin moisturizing containing minerals and quinoa extract - Google Patents
Cosmetic composition for skin moisturizing containing minerals and quinoa extractInfo
- Publication number
- NZ724357B2 NZ724357B2 NZ724357A NZ72435715A NZ724357B2 NZ 724357 B2 NZ724357 B2 NZ 724357B2 NZ 724357 A NZ724357 A NZ 724357A NZ 72435715 A NZ72435715 A NZ 72435715A NZ 724357 B2 NZ724357 B2 NZ 724357B2
- Authority
- NZ
- New Zealand
- Prior art keywords
- skin
- cosmetic composition
- quinoa
- composition
- skin moisturization
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 52
- 240000006162 Chenopodium quinoa Species 0.000 title claims abstract description 41
- 229910052500 inorganic mineral Inorganic materials 0.000 title claims abstract description 41
- 239000011707 mineral Substances 0.000 title claims abstract description 41
- 239000002537 cosmetic Substances 0.000 title claims abstract description 23
- 230000003020 moisturizing effect Effects 0.000 title claims description 14
- 101710088660 Filaggrin Proteins 0.000 claims abstract description 16
- 102100028314 Filaggrin Human genes 0.000 claims abstract description 15
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims abstract description 13
- 239000011701 zinc Substances 0.000 claims abstract description 13
- 229910052725 zinc Inorganic materials 0.000 claims abstract description 13
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 claims abstract description 12
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims abstract description 11
- 102100031784 Loricrin Human genes 0.000 claims abstract description 11
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims abstract description 11
- 239000011575 calcium Substances 0.000 claims abstract description 11
- 229910052791 calcium Inorganic materials 0.000 claims abstract description 11
- 108010079309 loricrin Proteins 0.000 claims abstract description 11
- 239000011777 magnesium Substances 0.000 claims abstract description 11
- 229910052749 magnesium Inorganic materials 0.000 claims abstract description 11
- 210000003491 skin Anatomy 0.000 claims description 47
- 210000002510 keratinocyte Anatomy 0.000 claims description 12
- 230000004069 differentiation Effects 0.000 claims description 5
- 102100039244 ETS-related transcription factor Elf-5 Human genes 0.000 claims 1
- 101000813141 Homo sapiens ETS-related transcription factor Elf-5 Proteins 0.000 claims 1
- 230000014509 gene expression Effects 0.000 abstract description 26
- 235000010755 mineral Nutrition 0.000 description 35
- 230000001737 promoting effect Effects 0.000 description 12
- 230000000694 effects Effects 0.000 description 10
- 230000008591 skin barrier function Effects 0.000 description 10
- 230000000052 comparative effect Effects 0.000 description 9
- 238000001914 filtration Methods 0.000 description 6
- 230000006870 function Effects 0.000 description 6
- 210000000434 stratum corneum Anatomy 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
- 238000000605 extraction Methods 0.000 description 5
- 108090000623 proteins and genes Proteins 0.000 description 5
- 101150116870 LORICRIN gene Proteins 0.000 description 4
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 4
- 210000000736 corneocyte Anatomy 0.000 description 4
- 235000013399 edible fruits Nutrition 0.000 description 4
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- 102100040445 Keratin, type I cytoskeletal 14 Human genes 0.000 description 3
- 239000000809 air pollutant Substances 0.000 description 3
- 231100001243 air pollutant Toxicity 0.000 description 3
- 150000002500 ions Chemical class 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 230000001954 sterilising effect Effects 0.000 description 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 2
- 241000219312 Chenopodium Species 0.000 description 2
- 102100023970 Keratin, type I cytoskeletal 10 Human genes 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 239000001110 calcium chloride Substances 0.000 description 2
- 229910001628 calcium chloride Inorganic materials 0.000 description 2
- 229960002713 calcium chloride Drugs 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 230000011712 cell development Effects 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 210000002615 epidermis Anatomy 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 230000003780 keratinization Effects 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 2
- 229960003390 magnesium sulfate Drugs 0.000 description 2
- 235000019341 magnesium sulphate Nutrition 0.000 description 2
- 229940099596 manganese sulfate Drugs 0.000 description 2
- 239000011702 manganese sulphate Substances 0.000 description 2
- 235000007079 manganese sulphate Nutrition 0.000 description 2
- SQQMAOCOWKFBNP-UHFFFAOYSA-L manganese(II) sulfate Chemical compound [Mn+2].[O-]S([O-])(=O)=O SQQMAOCOWKFBNP-UHFFFAOYSA-L 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 239000012046 mixed solvent Substances 0.000 description 2
- 230000009993 protective function Effects 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 238000003753 real-time PCR Methods 0.000 description 2
- 208000017520 skin disease Diseases 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 2
- 229960001763 zinc sulfate Drugs 0.000 description 2
- 229910000368 zinc sulfate Inorganic materials 0.000 description 2
- 229940058015 1,3-butylene glycol Drugs 0.000 description 1
- 235000006760 Acer pensylvanicum Nutrition 0.000 description 1
- 241000219317 Amaranthaceae Species 0.000 description 1
- 206010003645 Atopy Diseases 0.000 description 1
- DKPFZGUDAPQIHT-UHFFFAOYSA-N Butyl acetate Natural products CCCCOC(C)=O DKPFZGUDAPQIHT-UHFFFAOYSA-N 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 206010013786 Dry skin Diseases 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 102100034343 Integrase Human genes 0.000 description 1
- 102100025756 Keratin, type II cytoskeletal 5 Human genes 0.000 description 1
- 108010065038 Keratin-10 Proteins 0.000 description 1
- 108010066321 Keratin-14 Proteins 0.000 description 1
- 108010070553 Keratin-5 Proteins 0.000 description 1
- 102000011782 Keratins Human genes 0.000 description 1
- 108010076876 Keratins Proteins 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 238000002123 RNA extraction Methods 0.000 description 1
- 108010092799 RNA-directed DNA polymerase Proteins 0.000 description 1
- 229940022682 acetone Drugs 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 210000000270 basal cell Anatomy 0.000 description 1
- GEHJBWKLJVFKPS-UHFFFAOYSA-N bromochloroacetic acid Chemical compound OC(=O)C(Cl)Br GEHJBWKLJVFKPS-UHFFFAOYSA-N 0.000 description 1
- 235000019437 butane-1,3-diol Nutrition 0.000 description 1
- 229940043232 butyl acetate Drugs 0.000 description 1
- 238000010804 cDNA synthesis Methods 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 229940106189 ceramide Drugs 0.000 description 1
- 150000001783 ceramides Chemical class 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 150000001841 cholesterols Chemical class 0.000 description 1
- 239000002299 complementary DNA Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000037336 dry skin Effects 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 210000001339 epidermal cell Anatomy 0.000 description 1
- 210000005175 epidermal keratinocyte Anatomy 0.000 description 1
- 229940093499 ethyl acetate Drugs 0.000 description 1
- 235000019439 ethyl acetate Nutrition 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 229940099990 ogen Drugs 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000003252 repetitive effect Effects 0.000 description 1
- 239000011369 resultant mixture Substances 0.000 description 1
- 210000004761 scalp Anatomy 0.000 description 1
- 230000036559 skin health Effects 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/596—Mixtures of surface active compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/27—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/007—Preparations for dry skin
Abstract
The present invention relates to a cosmetic composition that promotes the expression of filaggrin and loricrin for skin moisturization. The composition contains a quinoa extract and minerals selected form calcium, manganese, magnesium, and zinc.
Description
COSMETIC COMPOSITION FOR SKIN RIZATION NING MINERALS AND QUINOA EXTRACT TECHNICAL FIELD The present invention relates to a cosmetic composition for skin moisturization containing minerals and a quinoa extract.
This application claims priority to Korea Patent Application No. 100037143 filed on Mar. 28, 2014, and the contents are herein incorporated by reference.
BACKGROUND ART The skin plays a vital role in protecting against the external nment, and such a function of the skin is called "barrier function". The skin barrier function is a protective function to protect against many different types of irritating stimuli from outside (e.g., als, air pollutants, dryness, UV radiation, etc.) and to prevent excessive moisture loss through transcutaneous evaporation. Such a protective function can be maintained only when the stratum corneum consisting of keratinocytes is normally formed.
The outmost layer of the epidermis, stratum corneum (horny layer), is formed from nocytes and composed of layers of corneocytes that is the final outcome of keratinocyte tion, and layers of lipids surrounding the corneocytes.
The corneocytes are characteristic cells derived from basal cells that continuously proliferate in the basal layer of the epidermis and undergo migration towards the skin e whilst undergoing changes of shape and function. As a ied period of time elapses, old corneocytes are shedding from the skin e and replaced by new ones. This s of repetitive modification is called the differentiation or keratinization of epidermal cells.
While forming the stratum corneum (horny layer) during the keratinization process, the keratinocytes also produce natural moisturizing s (NMFs) and intercellular lipids (e.g., ceramides, cholesterols, fatty acids, etc.). This allows the stratum corneum to have solidity and plasticity and to serve a skin barrier function.
The stratum m is liable to lose its skin barrier function due to certain life habit factors like frequent soap washing of the skin on the face or whole body, environmental factors like dry air, air pollutants, etc., or endogenous diseases including atopic skin diseases, senile skin diseases, etc. With a growing number of factors related to this issue in modern times, the more people are ing from the dry skin problem and the associated disturbances.
As well known in terms of the skin moisturization mechanism to maintain skin moisturization, it is very important to retain moisture in each layer of the skin by increasing the natural moisturizing factors (NMFs) that are made up of specific amino acids. The amino acids constituting the natural moisturizing factors (NMFs) are the breakdown product from the ation of a protein called "filaggrin" that is produced by the epidermal nocytes. Hence, the ability to promote the production of filaggrin is of significance in the expression of the skin rizing function.
In addition, the keratinocytes express specific keratins at each stage of differentiation. For example, the nocytes in the basal layer primarily express keratin 5 (K5) and keratin 14 (K14). As the keratinocytes move towards the upper, visible layer from the basal layer, they express pairs of keratin 10 (K10) and n 1 (K1) in place of the K5 and K14 pairs.
Loricrin, expressed late during terminal differentiation in epidermal keratinocytes, is linked to the cell membrane in the upper, granular layer to complete a protein, so it can be used as a marker for the terminal differentiation of keratinocytes.
Accordingly, there is a demand for development of a skin moisturizing preparation capable of ing the expression of filaggrin and loricrin for forming the stratum corneum to e the skin moisturization and strengthen the skin barrier for preventing moisture loss from the skin, in order to prevent skin ageing and maintain skin health against change of the external environment, including dry air, UV radiation and various air pollutants.
DISCLOSURE OF INVENTION It is therefore an object of the present ion to provide a cosmetic composition that promotes the expression of filaggrin and loricrin for forming the stratum corneum in order to promote the skin moisturization and then the skin barrier for preventing moisture loss from the skin.
The present invention is to provide a cosmetic composition for skin moisturization that contains ls including at least one or more ed from the group consisting of calcium, manganese, magnesium, and zinc; and a quinoa extract.
When d to the human body, the cosmetic ition for skin moisturization according to the t invention, containing a quinoa extract in addition to minerals, such as calcium, manganese, magnesium, or zinc, can promote the expression of natural moisturizing factors to enhance the skin moisturization and strengthen the skin barrier, thereby providing an excellent skin moisturizing effect to retain moisture in the skin.
BRIEF DESCRIPTION OF DRAWINGS is a graph showing the expression of filaggrin gene in a group treated with the composition of Comparative Example 1 (mineral treated group), a group treated with the composition of Comparative Example 2 (quinoa d group), and a group treated with the composition of Example 1 (mineral+quinoa d group) in relation to the untreated group. is a graph showing the expression of loricrin gene in a group treated with the composition of Comparative Example 1 (mineral treated group), a group treated with the composition of Comparative Example 2 (quinoa treated , and a group treated with the composition of Example 1 (mineral+quinoa treated group) in on to the untreated group.
BEST MODES FOR CARRYING OUT THE INVENTION The term "skin" as used herein refers to the tissue covering the surface of the body in animals. It may be used in a very inclusive sense to include scalp and hair in addition to the tissue covering the surface of the face or body.
The term "mineral(s)" as used herein refers to the element(s) except for oxygen (O), carbon (C), hydrogen (H), and nitrogen (N), as the major components of organic substances among the elements making up the human body and necessary to the physiological activities like the growth and maintenance of the human body.
The term "extract" as used herein may be used in a very inclusive sense to include all the substances obtained by extraction of natural components irrespective of the extraction method, the ting solvent, the extracted component, or the form of the extracted nce.
The term "quinoa" as used herein refers to the flower, leaves, fruits, and seeds of a species Chenopodium quinoa of the goosefoot genus in the Amaranthaceae family and Chenopodium subfamily.
In one ment of the present invention, the quinoa extract may be ed by a conventional method known to those skilled in the art, that is, an extraction method using a l solvent under normal temperature and pressure.
Preferably, the quinoa extract is obtained by drying out quinoa flowers, leaves, fruits or seeds and then performing tion with a solvent selected from the group consisting of water, anhydrous or hydrous lower C1-C4 alcohol, acetone, ethylacetate, butylacetate, and 1,3-butylene glycol, filtration and concentration.
In one ment of the present invention, the quinoa extract may be contained in an amount of 0.001 to 5 wt.% with respect to the total weight of the cosmetic composition for skin moisturization. The defined content of the quinoa extract, when applied to the skin in combination with the minerals, has an effect to e skin moisturization by promoting the filaggrin expression of the minerals and to strengthen the skin barrier by promoting the loricrin expression of the minerals. When the content of the quinoa extract is less than 0.001 wt.% with respect to the total weight of the cosmetic composition for skin rization, it is hard to make an effect of promoting the expression of filaggrin and loricrin. When the content of the quinoa extract is greater than 5 wt.%, there is the difficulty in the preparation in terms of stability and formulation.
In one embodiment of the present invention, the minerals may be ned in an amount of 0.001 to 1 wt.% with respect to the total weight of the cosmetic ition for skin moisturization. The defined content of the minerals, when applied to the skin in combination with the quinoa extract, has an effect to enhance skin moisturization by promoting the filaggrin expression of the minerals and to then the skin barrier by promoting the loricrin expression of the minerals.
When the t of the minerals is less than 0.001 wt.% with respect to the total weight of the ic composition for skin moisturization, it is hard to make an effect of promoting the expression of filaggrin and loricrin. When the content of the minerals is greater than 1 wt.%, there is the difficulty in the preparation in terms of stability and formulation.
In one embodiment of the present invention, the minerals may be at least one or more selected from the group consisting of calcium, manganese, magnesium, and zinc.
In one embodiment of the present ion, the minerals may include all of calcium, manganese, ium, and zinc. The minerals including all of calcium, manganese, magnesium, and zinc is more effective to offer skin moisturization and strengthen the skin barrier than the minerals including one of calcium, manganese, magnesium, and zinc.
In one embodiment of the present ion, the minerals may e calcium, manganese, magnesium, and zinc at a weight ratio of 5 to 20 : 1 to 5 : 5 to 20 : 0.5 to 5.
In one embodiment of the present invention, the cosmetic composition for skin moisturization may have a function to e keratinocyte differentiation. The minerals and the quinoa extract in the composition are excellent in promoting the gene expression of natural moisturizing factors and enhancing the differentiation of nocytes.
In one embodiment of the present invention, the cosmetic composition for skin moisturization may increase the natural moisturizing factors.
In one ment of the present invention, the natural moisturizing s are filaggrin and loricrin.
In one embodiment of the present invention, the cosmetic composition for skin moisturization may be foods, cosmetics, or pharmaceutical preparations.
Hereinafter, the construction and effects of the present invention will be described in r detail with reference to the following examples and experimental examples, which are given only for the better understanding of the present invention and not construed to limit the scope of the present invention. 0.2 kg of quinoa fruits and seeds are added to 1 L of a mixed solvent of water and ethanol (1:1 in v/v) for extraction, and the mixture is subjected to filtration with a membrane filter and then concentration to prepare a quinoa extract. 1 wt.% of the quinoa extract is added to 0.97 wt.% of minerals including magnesium sulfate, zinc sulfate, manganese sulfate, and calcium chloride dissolved in led water (to contain 0.35 wt.% of magnesium, 0.05 wt.% of zinc, 0.07 wt.% of manganese, and 0.5 wt.% of m). The resultant mixture is then subjected to a sterilizing filtration to prepare a composition. 0.97 wt.% of minerals including magnesium sulfate, zinc sulfate, manganese sulfate, and calcium chloride is dissolved in distilled water (to n 0.35 wt.% of magnesium, 0.05 wt.% of zinc, 0.07 wt.% of ese, and 0.5 wt.% of calcium). The solution thus obtained is subjected to a sterilizing filtration to prepare a composition. In the same manner as described in Example 1, 0.2 kg of quinoa fruits and seeds are added to 1 L of a mixed solvent of water and ethanol (1:1 in v/v) for extraction. The mixture thus obtained is ted to filtration with a membrane filter and then concentration to prepare a quinoa extract. 1 wt.% of the quinoa extract is added to distilled water, and the resultant e is then subjected to a sterilizing filtration to prepare a composition. Evaluation of NMF promoting function The following experiment is performed to evaluate the composition of Example 1 according to the present invention in regards to the effect of promoting the expression of natural moisturizing factors.
Keratinocyte cells cially available from ogen Inc. are cultured in a nocyte growth medium (EpiLife) containing a human keratinocyte growth supplement (HKGS) for a defined period of time to obtain three-subculture cells. The three-subculture keratinocytes are cultured up to 70 to 80 % on a 6-well plate. The individual wells are d with the respective compositions and classified into an untreated group, a group treated with the composition of ative Example 1 (mineral d group), a group treated with the composition of Comparative Example 2 (quinoa treated group), and a group treated with the composition of Example 1 al+quinoa treated group). After two -day cultivation, the cultured keratinocyte cells are subjected to RNA extraction with TRIzol.
Then cDNA synthesis is performed with a SuperScript reverse transcriptase III kit. As real-time PCR for comparing genes, 7500 Fast Real-Time PCR is carried out using a 2X TaqMan universal PCR e (10 µl), a 20X TaqMan expression assay mix (1 µl), cDNA (50 ng), and primers (Filaggrin: Hs00856927_g1*, Loricrin: Hs01894962_s1*).
The group treated with the composition of Comparative Example 1 (mineral treated group), the group treated with the ition of Comparative Example 2 (quinoa treated group), and the group treated with the composition of Example 1 (mineral+quinoa treated group) are analyz ed in s to the gene expression in comparison to the untreated group. The analysis results are charted in Table 1. The s concerning the expression of filaggrin and in genes are presented in FIGS. 1 and 2, respectively.
[Table 1] Div. rin gene Loricrin gene expression (relative expression (relative to control) to control) Control 1.0 1.0 Mineral treated 1.5 1.8 group (Comparative Example 1) Quinoa d group 0.8 1.1 (Comparative e Mineral+quinoa 2.6 2.6 treated group (Example 1) As can be seen from the mineral+quinoa treated group treated with the composition of e 1 according to the present invention is most excellent in the ability to promote the filaggrin gene expression for promoting the skin moisturization, whereas the quinoa treated group makes no effect in promoting the gene expression and the mineral treated group has an effect to promote the filaggrin gene expression.
As shown in the mineral+quinoa d group treated with the composition of Example 1 according to the present invention is most excellent in the ability to promote the loricrin gene expression for strengthening the skin barrier, whereas the quinoa treated group makes no effect in promoting the gene expression and the mineral treated group has an effect to e the loricrin gene expression.
This implicitly shows that the composition according to one embodiment of the present invention, containing both the minerals and the quinoa extract, has a synergistic effect to express the genes of natural moisturizing factors and carries out an excellent skin moisturizing function.
Claims (6)
1. A cosmetic composition for skin moisturization comprising: 5 a minerals mixture comprising all of calcium, manganese, ium, and zinc; and a quinoa extract, wherein a weight ratio of the m, manganese, magnesium, and zinc is 5 to 20 : 1 to 5 : 5 to 20 : 0.5 to 5, and 10 wherein the ic composition for skin moisturization increases a natural rizing factor, and the natural moisturizing factor comprises at least one or more selected from the group consisting of filaggrin and loricrin. 15
2. The cosmetic composition for skin moisturization as claimed in claim 1, wherein the quinoa extract is contained in an amount of 0.001 to 5 wt.% with respect to the total weight of the cosmetic composition for skin moisturization. 20
3. The cosmetic composition for skin rization as claimed in claim 1, wherein the minerals is contained in an amount of 0.001 to 1 wt.% with respect to the total weight of the cosmetic composition for skin moisturization.
4. The cosmetic composition for skin rization as claimed in claim 1, wherein the content of the quinoa extract is 1.0 wt% and the content of the mineral mixture is 0.97 wt% with regard to a total weight of the composition.
5. The cosmetic composition for skin moisturization as claimed in claim 4, wherein the mineral mixture consists of 0.5 wt% of calcium, 0.07 wt% of manganese, 0.35 wt% of magnesium, and % of zinc.
6. The cosmetic composition for skin moisturization as claimed in claim 1, n the cosmetic composition for skin moisturization has a function to promote keratinocyte differentiation. +_m._m=_s_ 28.5 “.23.: 3:59 538.: 6E Sana—E 28.5 ESE—2 “.38.: BEBE: 265 UOISSSJUXB QUBB 55: 25.5 NOE—5 :23: 6E :_._o_._o.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR10-2014-0037143 | 2014-03-28 | ||
| KR1020140037143A KR102142324B1 (en) | 2014-03-28 | 2014-03-28 | Cosmetic compositon comprsing mineral nutrients and quinoa extracts for mosturizing skin |
| PCT/KR2015/002970 WO2015147567A1 (en) | 2014-03-28 | 2015-03-26 | Cosmetic composition for skin moisturizing containing minerals and quinoa extract |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NZ724357A NZ724357A (en) | 2022-03-25 |
| NZ724357B2 true NZ724357B2 (en) | 2022-06-28 |
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