NZ617998A - 8-[3-amino-piperidin-1-yl]-xanthines, the production thereof and the use of the same as medicaments - Google Patents

8-[3-amino-piperidin-1-yl]-xanthines, the production thereof and the use of the same as medicaments

Info

Publication number
NZ617998A
NZ617998A NZ617998A NZ61799803A NZ617998A NZ 617998 A NZ617998 A NZ 617998A NZ 617998 A NZ617998 A NZ 617998A NZ 61799803 A NZ61799803 A NZ 61799803A NZ 617998 A NZ617998 A NZ 617998A
Authority
NZ
New Zealand
Prior art keywords
piperidin
linagliptin
xanthines
medicaments
amino
Prior art date
Application number
NZ617998A
Inventor
Frank Himmelsbach
Elke Langkopf
Matthias Eckhardt
Michael Mark
Roland Maier
Ralf R H Lotz
Mohammed Tadayyon
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10238243A external-priority patent/DE10238243A1/en
Priority claimed from DE10312353A external-priority patent/DE10312353A1/en
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of NZ617998A publication Critical patent/NZ617998A/en

Links

Abstract

Disclosed is Boc (tert-butyloxycarbonyl) protected linagliptin (i.e. 1-[(4-methyl-quinazolin-2- yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-[(R)-3-(tert-butyloxycarbonylamino)-piperidin-1-yl]-xanthine). Also disclosed is the preparation of a pharmaceutical composition comprising linagliptin, wherein said linagliptin is prepared by a process in which Boc-protected linagliptin is deprotected such as by treatment with trifluoroacetic acid, hydrochloric acid, or by treatment with bromotrimethylsilane or iodotrimethylsilane.
NZ617998A 2002-08-21 2003-08-18 8-[3-amino-piperidin-1-yl]-xanthines, the production thereof and the use of the same as medicaments NZ617998A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10238243A DE10238243A1 (en) 2002-08-21 2002-08-21 New 8-(3-amino-piperidin-1-yl)-xanthine derivatives are dipeptidylpeptidase-IV inhibitors useful for, e.g. treating diabetes mellitus, arthritis or obesity
DE10312353A DE10312353A1 (en) 2003-03-20 2003-03-20 New 8-(3-amino-piperidin-1-yl)-xanthine derivatives are dipeptidylpeptidase-IV inhibitors useful for, e.g. treating diabetes mellitus, arthritis or obesity
NZ60022703 2003-08-18

Publications (1)

Publication Number Publication Date
NZ617998A true NZ617998A (en) 2015-06-26

Family

ID=53490972

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ617998A NZ617998A (en) 2002-08-21 2003-08-18 8-[3-amino-piperidin-1-yl]-xanthines, the production thereof and the use of the same as medicaments

Country Status (1)

Country Link
NZ (1) NZ617998A (en)

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