NZ604011A - Crystalline forms of thalidomide and processes for their preparation - Google Patents
Crystalline forms of thalidomide and processes for their preparationInfo
- Publication number
- NZ604011A NZ604011A NZ604011A NZ60401111A NZ604011A NZ 604011 A NZ604011 A NZ 604011A NZ 604011 A NZ604011 A NZ 604011A NZ 60401111 A NZ60401111 A NZ 60401111A NZ 604011 A NZ604011 A NZ 604011A
- Authority
- NZ
- New Zealand
- Prior art keywords
- thalidomide
- anhydrous
- alpha
- crystalline
- mixtures
- Prior art date
Links
- UEJJHQNACJXSKW-UHFFFAOYSA-N 2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione Chemical compound O=C1C2=CC=CC=C2C(=O)N1C1CCC(=O)NC1=O UEJJHQNACJXSKW-UHFFFAOYSA-N 0.000 title abstract 10
- 229960003433 thalidomide Drugs 0.000 title abstract 10
- 239000000203 mixture Substances 0.000 abstract 5
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 abstract 4
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 abstract 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 abstract 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 abstract 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- BZLVMXJERCGZMT-UHFFFAOYSA-N Methyl tert-butyl ether Chemical compound COC(C)(C)C BZLVMXJERCGZMT-UHFFFAOYSA-N 0.000 abstract 2
- -1 aliphatic ketones Chemical class 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 239000003960 organic solvent Substances 0.000 abstract 2
- 239000011541 reaction mixture Substances 0.000 abstract 2
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 abstract 2
- ZIMWCUUEMGFXNW-VIFPVBQESA-N 2-[[(1s)-4-amino-1-carboxy-4-oxobutyl]carbamoyl]benzoic acid Chemical compound NC(=O)CC[C@@H](C(O)=O)NC(=O)C1=CC=CC=C1C(O)=O ZIMWCUUEMGFXNW-VIFPVBQESA-N 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 239000007822 coupling agent Substances 0.000 abstract 1
- 239000013078 crystal Substances 0.000 abstract 1
- 150000002170 ethers Chemical class 0.000 abstract 1
- FVSKHRXBFJPNKK-UHFFFAOYSA-N propionitrile Chemical compound CCC#N FVSKHRXBFJPNKK-UHFFFAOYSA-N 0.000 abstract 1
- 238000010992 reflux Methods 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN1758MU2010 | 2010-06-09 | ||
| PCT/GB2011/051078 WO2011154739A1 (en) | 2010-06-09 | 2011-06-09 | Crystalline forms of thalidomide and processes for their preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ604011A true NZ604011A (en) | 2015-04-24 |
Family
ID=44384914
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ604011A NZ604011A (en) | 2010-06-09 | 2011-06-09 | Crystalline forms of thalidomide and processes for their preparation |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20130143923A1 (OSRAM) |
| EP (1) | EP2580205A1 (OSRAM) |
| JP (1) | JP2013528206A (OSRAM) |
| CN (1) | CN103068812A (OSRAM) |
| AU (1) | AU2011263493B2 (OSRAM) |
| CA (1) | CA2801835A1 (OSRAM) |
| NZ (1) | NZ604011A (OSRAM) |
| WO (1) | WO2011154739A1 (OSRAM) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102924432A (zh) * | 2012-11-09 | 2013-02-13 | 常州制药厂有限公司 | 一种高纯度沙利度胺的制备方法 |
| EP2815749A1 (en) * | 2013-06-20 | 2014-12-24 | IP Gesellschaft für Management mbH | Solid form of 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione having specified X-ray diffraction pattern |
| BR112015031291A2 (pt) * | 2013-06-20 | 2017-07-25 | Bayer Cropscience Ag | derivados de sulfureto de arila e derivados de arilalquil sulfóxido como acaricidas e inseticidas |
| US20180228907A1 (en) | 2014-04-14 | 2018-08-16 | Arvinas, Inc. | Cereblon ligands and bifunctional compounds comprising the same |
| KR20250127179A (ko) * | 2014-04-14 | 2025-08-26 | 아비나스 오퍼레이션스, 인코포레이티드 | 단백질분해의 이미드-기초된 조절인자 및 연관된 이용 방법 |
| CN104710411B (zh) * | 2015-03-13 | 2017-04-26 | 安润医药科技（苏州）有限公司 | 阿伐那非的合成方法 |
| CN110498788B (zh) * | 2018-05-16 | 2021-09-17 | 欣凯医药化工中间体（上海）有限公司 | 一种高纯度沙利度胺α晶型的制备方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB768821A (en) | 1954-05-17 | 1957-02-20 | Gruenenthal Chemie | Novel products of the amino-piperidine-2, 6-dione series |
| US5463063A (en) | 1993-07-02 | 1995-10-31 | Celgene Corporation | Ring closure of N-phthaloylglutamines |
| CN1164586C (zh) * | 2002-10-28 | 2004-09-01 | 中国科学院长春应用化学研究所 | 沙利度胺及其衍生物的制备方法 |
| US20050182097A1 (en) * | 2003-12-30 | 2005-08-18 | Zeldis Jerome B. | Methods and compositions using thalidomide for the treatment and management of central nervous system disorders or diseases |
| ITMI20041113A1 (it) * | 2004-06-01 | 2004-09-01 | Antibioticos Spa | Processo per la sintesi della talidomide |
| WO2008035378A2 (en) * | 2006-09-20 | 2008-03-27 | Matrix Laboratories Ltd | An improved process for the preparation of thalidomide |
| WO2009083724A1 (en) | 2007-12-27 | 2009-07-09 | Cipla Limited | Processes for the preparation of thalidomide |
| CN102260241A (zh) * | 2010-05-26 | 2011-11-30 | 重庆医药工业研究院有限责任公司 | 一种沙利度胺α晶型的工业化制备方法 |
-
2011
- 2011-06-09 CN CN2011800385583A patent/CN103068812A/zh active Pending
- 2011-06-09 JP JP2013513760A patent/JP2013528206A/ja active Pending
- 2011-06-09 US US13/702,754 patent/US20130143923A1/en not_active Abandoned
- 2011-06-09 AU AU2011263493A patent/AU2011263493B2/en not_active Ceased
- 2011-06-09 WO PCT/GB2011/051078 patent/WO2011154739A1/en not_active Ceased
- 2011-06-09 EP EP11726483.8A patent/EP2580205A1/en not_active Withdrawn
- 2011-06-09 NZ NZ604011A patent/NZ604011A/en unknown
- 2011-06-09 CA CA2801835A patent/CA2801835A1/en not_active Abandoned
-
2015
- 2015-02-12 US US14/621,307 patent/US20150218126A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20150218126A1 (en) | 2015-08-06 |
| EP2580205A1 (en) | 2013-04-17 |
| AU2011263493A1 (en) | 2013-01-10 |
| AU2011263493A8 (en) | 2013-02-21 |
| JP2013528206A (ja) | 2013-07-08 |
| CN103068812A (zh) | 2013-04-24 |
| US20130143923A1 (en) | 2013-06-06 |
| CA2801835A1 (en) | 2012-12-15 |
| AU2011263493B2 (en) | 2015-08-06 |
| WO2011154739A1 (en) | 2011-12-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ASS | Change of ownership |
Owner name: GENERICS (UK) LIMITED, GB Effective date: 20140703 |
|
| PSEA | Patent sealed | ||
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 3 YEARS UNTIL 09 JUN 2018 BY COMPUTER PACKAGES INC Effective date: 20150818 |
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| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 09 JUN 2019 BY RENEWALS TEAM Effective date: 20180510 |
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| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 09 JUN 2020 BY RENEWALS TEAM Effective date: 20190516 |
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| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 09 JUN 2021 BY ENVOY Effective date: 20200609 |
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| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 09 JUN 2022 BY IPAN GMBH Effective date: 20210526 |
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Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 09 JUN 2023 BY IPAN GMBH Effective date: 20220526 |
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