NZ596390A - Indole derivative modulators of the alpha 7 nachr - Google Patents
Indole derivative modulators of the alpha 7 nachrInfo
- Publication number
- NZ596390A NZ596390A NZ596390A NZ59639010A NZ596390A NZ 596390 A NZ596390 A NZ 596390A NZ 596390 A NZ596390 A NZ 596390A NZ 59639010 A NZ59639010 A NZ 59639010A NZ 596390 A NZ596390 A NZ 596390A
- Authority
- NZ
- New Zealand
- Prior art keywords
- nachr
- alpha
- trifluoromethyl
- indole derivative
- methyl
- Prior art date
Links
- 150000002475 indoles Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000028698 Cognitive impairment Diseases 0.000 abstract 1
- 208000028017 Psychotic disease Diseases 0.000 abstract 1
- 208000010877 cognitive disease Diseases 0.000 abstract 1
- KGAYUJXLASXXSW-UHFFFAOYSA-N n-[[7-(1-methylimidazol-2-yl)-2-(trifluoromethyl)-1h-indol-5-yl]methyl]-6-(trifluoromethyl)pyridine-3-carboxamide Chemical compound CN1C=CN=C1C1=CC(CNC(=O)C=2C=NC(=CC=2)C(F)(F)F)=CC2=C1NC(C(F)(F)F)=C2 KGAYUJXLASXXSW-UHFFFAOYSA-N 0.000 abstract 1
- SKKDTMKJPUJOLJ-UHFFFAOYSA-N n-[[7-(2-methoxypyridin-3-yl)-2-(trifluoromethyl)-1h-indol-5-yl]methyl]-6-(trifluoromethyl)pyridine-3-carboxamide Chemical compound COC1=NC=CC=C1C1=CC(CNC(=O)C=2C=NC(=CC=2)C(F)(F)F)=CC2=C1NC(C(F)(F)F)=C2 SKKDTMKJPUJOLJ-UHFFFAOYSA-N 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Child & Adolescent Psychology (AREA)
- Anesthesiology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16974209P | 2009-04-16 | 2009-04-16 | |
| PCT/EP2010/054910 WO2010119078A1 (en) | 2009-04-16 | 2010-04-14 | Indole derivative modulators of the alpha 7 nachr |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ596390A true NZ596390A (en) | 2013-08-30 |
Family
ID=42235211
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ596390A NZ596390A (en) | 2009-04-16 | 2010-04-14 | Indole derivative modulators of the alpha 7 nachr |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US8829031B2 (enExample) |
| EP (1) | EP2419420B1 (enExample) |
| JP (1) | JP5642154B2 (enExample) |
| KR (1) | KR20120089190A (enExample) |
| CN (1) | CN102712622B (enExample) |
| AU (1) | AU2010238518A1 (enExample) |
| BR (1) | BRPI1014471A2 (enExample) |
| CA (1) | CA2758772A1 (enExample) |
| EA (1) | EA019518B1 (enExample) |
| IL (1) | IL215551A (enExample) |
| MX (1) | MX2011010734A (enExample) |
| NZ (1) | NZ596390A (enExample) |
| SG (1) | SG175084A1 (enExample) |
| WO (1) | WO2010119078A1 (enExample) |
| ZA (1) | ZA201107988B (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2419420B1 (en) * | 2009-04-16 | 2013-03-13 | Proximagen Limited | Indole derivative modulators of the alpha 7 nachr |
| GB201012686D0 (en) * | 2010-07-28 | 2010-09-15 | Glaxo Group Ltd | Novel compounds |
| TW201245185A (en) | 2011-04-01 | 2012-11-16 | Lundbeck & Co As H | New positive allosteric modulators of nicotinic acetylcholine receptor |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9903997D0 (sv) * | 1999-11-03 | 1999-11-03 | Astra Ab | New compounds |
| US20040242559A1 (en) * | 2003-04-25 | 2004-12-02 | Aventis Pharma S.A. | Novel indole derivatives, preparation thereof as medicinal products and pharmaceutical compositions, and especially as KDR inhibitors |
| GB0403155D0 (en) * | 2004-02-12 | 2004-03-17 | Vernalis Res Ltd | Chemical compounds |
| JP2010520206A (ja) * | 2007-03-02 | 2010-06-10 | メルク・シャープ・エンド・ドーム・コーポレイション | ビピリジンカルボキサミドオレキシン受容体アンタゴニスト |
| JP2011511800A (ja) * | 2008-02-07 | 2011-04-14 | アボット・ラボラトリーズ | 正のアロステリックな修飾物質としてのアミド誘導体およびこれらの使用方法 |
| TW201004939A (en) * | 2008-04-17 | 2010-02-01 | Glaxo Group Ltd | Novel compounds |
| EP2419420B1 (en) * | 2009-04-16 | 2013-03-13 | Proximagen Limited | Indole derivative modulators of the alpha 7 nachr |
-
2010
- 2010-04-14 EP EP10713943A patent/EP2419420B1/en not_active Not-in-force
- 2010-04-14 CN CN201080024640.6A patent/CN102712622B/zh not_active Expired - Fee Related
- 2010-04-14 MX MX2011010734A patent/MX2011010734A/es active IP Right Grant
- 2010-04-14 AU AU2010238518A patent/AU2010238518A1/en not_active Abandoned
- 2010-04-14 US US13/263,370 patent/US8829031B2/en not_active Expired - Fee Related
- 2010-04-14 EA EA201101325A patent/EA019518B1/ru not_active IP Right Cessation
- 2010-04-14 WO PCT/EP2010/054910 patent/WO2010119078A1/en not_active Ceased
- 2010-04-14 JP JP2012505160A patent/JP5642154B2/ja not_active Expired - Fee Related
- 2010-04-14 CA CA2758772A patent/CA2758772A1/en not_active Abandoned
- 2010-04-14 KR KR1020117027026A patent/KR20120089190A/ko not_active Ceased
- 2010-04-14 NZ NZ596390A patent/NZ596390A/xx not_active IP Right Cessation
- 2010-04-14 SG SG2011072683A patent/SG175084A1/en unknown
- 2010-04-14 BR BRPI1014471A patent/BRPI1014471A2/pt not_active IP Right Cessation
-
2011
- 2011-10-05 IL IL215551A patent/IL215551A/en not_active IP Right Cessation
- 2011-11-01 ZA ZA2011/07988A patent/ZA201107988B/en unknown
-
2014
- 2014-08-07 US US14/453,816 patent/US20150038517A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20150038517A1 (en) | 2015-02-05 |
| IL215551A (en) | 2014-07-31 |
| BRPI1014471A2 (pt) | 2016-04-05 |
| US8829031B2 (en) | 2014-09-09 |
| CA2758772A1 (en) | 2010-10-21 |
| CN102712622A (zh) | 2012-10-03 |
| EP2419420B1 (en) | 2013-03-13 |
| SG175084A1 (en) | 2011-11-28 |
| IL215551A0 (en) | 2011-12-29 |
| WO2010119078A1 (en) | 2010-10-21 |
| EP2419420A1 (en) | 2012-02-22 |
| AU2010238518A1 (en) | 2011-12-01 |
| US20120136009A1 (en) | 2012-05-31 |
| WO2010119078A9 (en) | 2011-02-03 |
| JP2012524043A (ja) | 2012-10-11 |
| MX2011010734A (es) | 2011-12-06 |
| JP5642154B2 (ja) | 2014-12-17 |
| CN102712622B (zh) | 2014-05-07 |
| EA019518B1 (ru) | 2014-04-30 |
| KR20120089190A (ko) | 2012-08-09 |
| EA201101325A1 (ru) | 2012-05-30 |
| ZA201107988B (en) | 2012-07-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PSEA | Patent sealed | ||
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 3 YEARS UNTIL 14 APR 2017 BY CPA GLOBAL Effective date: 20140306 |
|
| LAPS | Patent lapsed |