NZ586666A - Estradiol-containing drug delivery system - Google Patents
Estradiol-containing drug delivery systemInfo
- Publication number
- NZ586666A NZ586666A NZ586666A NZ58666609A NZ586666A NZ 586666 A NZ586666 A NZ 586666A NZ 586666 A NZ586666 A NZ 586666A NZ 58666609 A NZ58666609 A NZ 58666609A NZ 586666 A NZ586666 A NZ 586666A
- Authority
- NZ
- New Zealand
- Prior art keywords
- estradiol
- dosage form
- form according
- film matrix
- unit dosage
- Prior art date
Links
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 title claims abstract description 205
- 229960005309 estradiol Drugs 0.000 title claims abstract description 204
- 229930182833 estradiol Natural products 0.000 title claims abstract description 202
- 238000012377 drug delivery Methods 0.000 title description 8
- 239000002552 dosage form Substances 0.000 claims abstract description 92
- 239000011159 matrix material Substances 0.000 claims abstract description 80
- 229920000642 polymer Polymers 0.000 claims abstract description 37
- 208000024891 symptom Diseases 0.000 claims abstract description 31
- 150000002148 esters Chemical class 0.000 claims abstract description 26
- 206010060800 Hot flush Diseases 0.000 claims abstract description 19
- 208000001132 Osteoporosis Diseases 0.000 claims abstract description 15
- 230000001457 vasomotor Effects 0.000 claims abstract description 13
- 208000008454 Hyperhidrosis Diseases 0.000 claims abstract description 11
- 206010071018 Urogenital atrophy Diseases 0.000 claims abstract description 11
- 230000007423 decrease Effects 0.000 claims abstract description 10
- 210000000988 bone and bone Anatomy 0.000 claims abstract description 9
- 206010033557 Palpitations Diseases 0.000 claims abstract description 8
- 208000010392 Bone Fractures Diseases 0.000 claims abstract description 6
- 229910052500 inorganic mineral Inorganic materials 0.000 claims abstract description 6
- 239000011707 mineral Substances 0.000 claims abstract description 6
- 206010019233 Headaches Diseases 0.000 claims abstract description 5
- 206010028813 Nausea Diseases 0.000 claims abstract description 5
- 231100000869 headache Toxicity 0.000 claims abstract description 5
- 230000008693 nausea Effects 0.000 claims abstract description 5
- 230000036565 night sweats Effects 0.000 claims abstract description 4
- 206010029410 night sweats Diseases 0.000 claims abstract description 4
- 239000000203 mixture Substances 0.000 claims description 35
- 239000002904 solvent Substances 0.000 claims description 35
- ZVVGLAMWAQMPDR-WVEWYJOQSA-N (8r,9s,13s,14s,17s)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol;hydrate Chemical compound O.OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1.OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 ZVVGLAMWAQMPDR-WVEWYJOQSA-N 0.000 claims description 32
- 239000003814 drug Substances 0.000 claims description 32
- 229960003851 estradiol hemihydrate Drugs 0.000 claims description 32
- 239000000262 estrogen Substances 0.000 claims description 31
- 229940011871 estrogen Drugs 0.000 claims description 31
- 238000000034 method Methods 0.000 claims description 26
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 25
- 238000004519 manufacturing process Methods 0.000 claims description 23
- 238000011282 treatment Methods 0.000 claims description 22
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 21
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 21
- -1 pentafluorobenzoyl Chemical group 0.000 claims description 19
- RSEPBGGWRJCQGY-RBRWEJTLSA-N Estradiol valerate Chemical compound C1CC2=CC(O)=CC=C2[C@@H]2[C@@H]1[C@@H]1CC[C@H](OC(=O)CCCC)[C@@]1(C)CC2 RSEPBGGWRJCQGY-RBRWEJTLSA-N 0.000 claims description 18
- 229960004766 estradiol valerate Drugs 0.000 claims description 18
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical class C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 claims description 15
- 241000124008 Mammalia Species 0.000 claims description 13
- 239000000583 progesterone congener Substances 0.000 claims description 12
- 239000000463 material Substances 0.000 claims description 11
- 238000002360 preparation method Methods 0.000 claims description 10
- 210000002966 serum Anatomy 0.000 claims description 9
- 229940088679 drug related substance Drugs 0.000 claims description 8
- 239000008186 active pharmaceutical agent Substances 0.000 claims description 7
- 239000007788 liquid Substances 0.000 claims description 7
- 229940068196 placebo Drugs 0.000 claims description 7
- 239000000902 placebo Substances 0.000 claims description 7
- 229920002472 Starch Polymers 0.000 claims description 6
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 6
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 6
- 235000019698 starch Nutrition 0.000 claims description 6
- 102000004169 proteins and genes Human genes 0.000 claims description 5
- 108090000623 proteins and genes Proteins 0.000 claims description 5
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 4
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 4
- 229920001059 synthetic polymer Polymers 0.000 claims description 4
- DNXHEGUUPJUMQT-UHFFFAOYSA-N (+)-estrone Natural products OC1=CC=C2C3CCC(C)(C(CC4)=O)C4C3CCC2=C1 DNXHEGUUPJUMQT-UHFFFAOYSA-N 0.000 claims description 3
- LDSYPJSYQOUQMN-WAJSLEGFSA-N (8R,9S,13S,14S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol sulfuric acid Chemical compound OS(O)(=O)=O.OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)O)[C@@H]4[C@@H]3CCC2=C1 LDSYPJSYQOUQMN-WAJSLEGFSA-N 0.000 claims description 3
- UOACKFBJUYNSLK-XRKIENNPSA-N Estradiol Cypionate Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H](C4=CC=C(O)C=C4CC3)CC[C@@]21C)C(=O)CCC1CCCC1 UOACKFBJUYNSLK-XRKIENNPSA-N 0.000 claims description 3
- JQIYNMYZKRGDFK-RUFWAXPRSA-N Estradiol dipropionate Chemical compound C1CC2=CC(OC(=O)CC)=CC=C2[C@@H]2[C@@H]1[C@@H]1CC[C@H](OC(=O)CC)[C@@]1(C)CC2 JQIYNMYZKRGDFK-RUFWAXPRSA-N 0.000 claims description 3
- TXHUMRBWIWWBGW-UHFFFAOYSA-N Estradiol undecylate Natural products C1CC2=CC(O)=CC=C2C2C1C1CCC(OC(=O)CCCCCCCCCC)C1(C)CC2 TXHUMRBWIWWBGW-UHFFFAOYSA-N 0.000 claims description 3
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 3
- YXYXCSOJKUAPJI-ZBRFXRBCSA-N [(8r,9s,13s,14s,17s)-17-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-yl] sulfamate Chemical compound NS(=O)(=O)OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 YXYXCSOJKUAPJI-ZBRFXRBCSA-N 0.000 claims description 3
- 238000003556 assay Methods 0.000 claims description 3
- 239000001913 cellulose Substances 0.000 claims description 3
- 235000010980 cellulose Nutrition 0.000 claims description 3
- 229960003575 estradiol acetate Drugs 0.000 claims description 3
- FHXBMXJMKMWVRG-SLHNCBLASA-N estradiol acetate Chemical compound C1C[C@]2(C)[C@@H](O)CC[C@H]2[C@@H]2CCC3=CC(OC(=O)C)=CC=C3[C@H]21 FHXBMXJMKMWVRG-SLHNCBLASA-N 0.000 claims description 3
- 229960005416 estradiol cypionate Drugs 0.000 claims description 3
- 229950010215 estradiol dipropionate Drugs 0.000 claims description 3
- RFWTZQAOOLFXAY-BZDYCCQFSA-N estradiol enanthate Chemical compound C1CC2=CC(O)=CC=C2[C@@H]2[C@@H]1[C@@H]1CC[C@H](OC(=O)CCCCCC)[C@@]1(C)CC2 RFWTZQAOOLFXAY-BZDYCCQFSA-N 0.000 claims description 3
- 229950005281 estradiol undecylate Drugs 0.000 claims description 3
- TXHUMRBWIWWBGW-GVGNIZHQSA-N estradiol undecylate Chemical compound C1CC2=CC(O)=CC=C2[C@@H]2[C@@H]1[C@@H]1CC[C@H](OC(=O)CCCCCCCCCC)[C@@]1(C)CC2 TXHUMRBWIWWBGW-GVGNIZHQSA-N 0.000 claims description 3
- 239000008107 starch Substances 0.000 claims description 3
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 claims description 2
- UYIFTLBWAOGQBI-BZDYCCQFSA-N Benzhormovarine Chemical compound C([C@@H]1[C@@H](C2=CC=3)CC[C@]4([C@H]1CC[C@@H]4O)C)CC2=CC=3OC(=O)C1=CC=CC=C1 UYIFTLBWAOGQBI-BZDYCCQFSA-N 0.000 claims description 2
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- DNXHEGUUPJUMQT-CBZIJGRNSA-N Estrone Chemical compound OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 DNXHEGUUPJUMQT-CBZIJGRNSA-N 0.000 claims description 2
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- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Nutrition Science (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physiology (AREA)
- Otolaryngology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2830208P | 2008-02-13 | 2008-02-13 | |
| EP08002633 | 2008-02-13 | ||
| PCT/EP2009/051303 WO2009101021A2 (en) | 2008-02-13 | 2009-02-05 | Estradiol-containing drug delivery system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ586666A true NZ586666A (en) | 2012-04-27 |
Family
ID=39365963
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ586666A NZ586666A (en) | 2008-02-13 | 2009-02-05 | Estradiol-containing drug delivery system |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US20110097405A1 (https=) |
| EP (1) | EP2249803A2 (https=) |
| JP (1) | JP2011511823A (https=) |
| KR (1) | KR20100125309A (https=) |
| CN (1) | CN101945646A (https=) |
| AR (1) | AR070375A1 (https=) |
| AU (1) | AU2009214193A1 (https=) |
| BR (1) | BRPI0908477A2 (https=) |
| CA (1) | CA2714340A1 (https=) |
| CL (1) | CL2009000326A1 (https=) |
| CO (1) | CO6290633A2 (https=) |
| CR (1) | CR11632A (https=) |
| DO (1) | DOP2010000252A (https=) |
| EA (1) | EA201001245A1 (https=) |
| EC (1) | ECSP10010400A (https=) |
| IL (1) | IL206640A0 (https=) |
| MA (1) | MA32073B1 (https=) |
| MX (1) | MX2010008940A (https=) |
| NZ (1) | NZ586666A (https=) |
| PA (1) | PA8816001A1 (https=) |
| PE (1) | PE20091471A1 (https=) |
| TN (1) | TN2010000302A1 (https=) |
| TW (1) | TW200940095A (https=) |
| UA (1) | UA102680C2 (https=) |
| UY (1) | UY31660A1 (https=) |
| WO (1) | WO2009101021A2 (https=) |
| ZA (1) | ZA201006517B (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101310710B1 (ko) * | 2011-03-23 | 2013-09-27 | 한미약품 주식회사 | 오메가-3 지방산 에스테르 및 ＨＭＧ-ＣｏＡ 환원효소 억제제를 포함하는 경구용 복합 조성물 |
| GB201200062D0 (en) | 2012-01-04 | 2012-02-15 | Innotesto Bvba | Estradiol oromucosal liquid compositions |
| WO2014018075A1 (en) | 2012-07-23 | 2014-01-30 | Crayola, Llc | Dissolvable films and methods of using the same |
| WO2016140981A1 (en) * | 2015-03-02 | 2016-09-09 | Colonaryconcepts Llc | Compounds and methods for peg metabolite and peg breakdown product assays |
| CN119055659A (zh) * | 2024-09-03 | 2024-12-03 | 南通大学 | 17α雌二醇或其化学修饰衍生物在制备预防和/或治疗男性性腺功能低下的药物中的应用 |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4136162A (en) * | 1974-07-05 | 1979-01-23 | Schering Aktiengesellschaft | Medicament carriers in the form of film having active substance incorporated therein |
| JPS56140915A (en) * | 1980-04-07 | 1981-11-04 | Yamanouchi Pharmaceut Co Ltd | Pharmaceutical preparation for solid drug |
| DE3347125A1 (de) * | 1983-12-22 | 1985-07-11 | Schering AG, 1000 Berlin und 4709 Bergkamen | Mehrstufenkombinationspraeparat und seine verwendung zur oralen kontrazeption |
| US4764378A (en) * | 1986-02-10 | 1988-08-16 | Zetachron, Inc. | Buccal drug dosage form |
| US4800087A (en) * | 1986-11-24 | 1989-01-24 | Mehta Atul M | Taste-masked pharmaceutical compositions |
| US5073374A (en) * | 1988-11-30 | 1991-12-17 | Schering Corporation | Fast dissolving buccal tablet |
| ES2105262T3 (es) * | 1992-05-18 | 1997-10-16 | Minnesota Mining & Mfg | Dispositivo de suministro de farmaco a traves de las mucosas. |
| DE4426709A1 (de) * | 1994-07-20 | 1996-01-25 | Schering Ag | Steroidale Sexualhormone enthaltende feste Arzneiformen |
| DE19646392A1 (de) * | 1996-11-11 | 1998-05-14 | Lohmann Therapie Syst Lts | Zubereitung zur Anwendung in der Mundhöhle mit einer an der Schleimhaut haftklebenden, Pharmazeutika oder Kosmetika zur dosierten Abgabe enthaltenden Schicht |
| CH693255A5 (de) * | 1997-06-13 | 2003-05-15 | Eprova Ag | Verwendung von Tetrahydrofolaten in der natürlichenstereoisomeren Form zur Herstellung einer pharmazeutischenZubereitung geeignet zur Beeinflussung des Homocystein-Spiegels. |
| CA2329005C (en) * | 1998-04-17 | 2006-01-03 | Ortho-Mcneil Pharmaceutical, Inc. | Folic acid-containing pharmaceutical compositions, and related methods and delivery systems |
| US6552024B1 (en) * | 1999-01-21 | 2003-04-22 | Lavipharm Laboratories Inc. | Compositions and methods for mucosal delivery |
| CH693905A5 (de) * | 1999-04-15 | 2004-04-15 | Eprova Ag | Stabile kristalline Salze von 5-Methyltetrahydrofolsäure. |
| US6264981B1 (en) * | 1999-10-27 | 2001-07-24 | Anesta Corporation | Oral transmucosal drug dosage using solid solution |
| US20030092658A1 (en) * | 2001-02-02 | 2003-05-15 | Meyers Rachel E. | Novel human enzyme family members and uses thereof |
| ATE302790T1 (de) * | 2000-04-12 | 2005-09-15 | Schering Ag | 8beta-substituierte-11beta-pentyl-und 11beta- hexyl-estra-1,3,5(10)-trienderivate |
| EP1216712A1 (en) * | 2000-12-20 | 2002-06-26 | Schering Aktiengesellschaft | Cyclodextrin-drospirenone inclusion complexes |
| EP1390038A2 (en) * | 2001-05-16 | 2004-02-25 | Endeavor Pharmaceuticals | Treatment of conditions relating to hormone deficiencies by administration of progestins |
| JP4019374B2 (ja) * | 2001-07-27 | 2007-12-12 | アステラス製薬株式会社 | 口腔内速崩壊錠用徐放性微粒子含有組成物およびその製造法 |
| DE60215224T2 (de) * | 2002-02-21 | 2007-08-23 | Schering Aktiengesellschaft | Pharmazeutische zusammensetzung, enthaltend ein oder mehrere steroide, eine oder mehrere tetrahydrofolatverbindungen und vitamin b12 |
| DE10207394B4 (de) * | 2002-02-21 | 2007-03-29 | Lts Lohmann Therapie-Systeme Ag | Geschmacksmaskierte oblatenförmige Arzneizubereitung |
| US20070059346A1 (en) * | 2003-07-01 | 2007-03-15 | Todd Maibach | Film comprising therapeutic agents |
| CN1913876B (zh) * | 2003-12-09 | 2013-06-26 | 大日本住友制药株式会社 | 含药物的颗粒和包含这种颗粒的固体制剂 |
| MY142989A (en) * | 2004-03-10 | 2011-02-14 | Bayer Schering Pharma Ag | Stabilised supersaturated solids of lipophilic drugs |
| US20050220825A1 (en) * | 2004-03-10 | 2005-10-06 | Adrian Funke | Molecular dispersions of drospirenone |
| DE102004023984A1 (de) * | 2004-05-14 | 2005-12-08 | Hf Arzneimittelforschung Gmbh | Filmförmiges, oral zu verabreichendes Arzneimittel, enthaltend Estriol |
| US20060105038A1 (en) * | 2004-11-12 | 2006-05-18 | Eurand Pharmaceuticals Limited | Taste-masked pharmaceutical compositions prepared by coacervation |
| DE102005015128B4 (de) * | 2005-03-31 | 2008-12-11 | Bayer Schering Pharma Aktiengesellschaft | Wafer enthaltend Steroidhormone |
| US20060275364A1 (en) * | 2005-05-26 | 2006-12-07 | Ahmed Salah U | Flexible Solid Dosage Forms and Methods of Making and Using the Same |
| DE102005058569B4 (de) * | 2005-12-08 | 2010-07-15 | Lts Lohmann Therapie-Systeme Ag | Schaumwafer mit Polyvinylalkohol-Polyethylenglycol-Pfropfcopolymer |
| DE102005062270A1 (de) * | 2005-12-24 | 2007-06-28 | Bayer Technology Services Gmbh | Geschmacksmaskierung von Pulvern |
| DE102006003512A1 (de) * | 2006-01-24 | 2007-08-02 | Bayer Schering Pharma Ag | Plättchenförmige Arzneimittel zur transbukkalen Applikation von Arzneistoffen |
| EP1867321A3 (en) * | 2006-06-07 | 2008-11-19 | Familplan Consulting Ltd. | A pharmaceutical product adapted for oral transmucosal administration comprising a pharmaceutical agent |
| DE102006027792A1 (de) * | 2006-06-16 | 2007-12-20 | Lts Lohmann Therapie-Systeme Ag | Antidepressiva-Kombinations-Wafer |
| DE102006027796A1 (de) * | 2006-06-16 | 2007-12-20 | Lts Lohmann Therapie-Systeme Ag | Estrogen-Gestagen-Kombinationen |
| US20080058272A1 (en) * | 2006-08-29 | 2008-03-06 | Juergen Becker | Nonamer Peptides for Cancer Treatment |
-
2009
- 2009-02-05 BR BRPI0908477A patent/BRPI0908477A2/pt not_active IP Right Cessation
- 2009-02-05 NZ NZ586666A patent/NZ586666A/en not_active IP Right Cessation
- 2009-02-05 EP EP09709466A patent/EP2249803A2/en not_active Withdrawn
- 2009-02-05 KR KR1020107020216A patent/KR20100125309A/ko not_active Withdrawn
- 2009-02-05 CN CN2009801052091A patent/CN101945646A/zh active Pending
- 2009-02-05 WO PCT/EP2009/051303 patent/WO2009101021A2/en not_active Ceased
- 2009-02-05 JP JP2010546291A patent/JP2011511823A/ja not_active Withdrawn
- 2009-02-05 MX MX2010008940A patent/MX2010008940A/es unknown
- 2009-02-05 US US12/867,409 patent/US20110097405A1/en not_active Abandoned
- 2009-02-05 EA EA201001245A patent/EA201001245A1/ru unknown
- 2009-02-05 CA CA2714340A patent/CA2714340A1/en not_active Abandoned
- 2009-02-05 AU AU2009214193A patent/AU2009214193A1/en not_active Abandoned
- 2009-02-10 UA UAA201010636A patent/UA102680C2/ru unknown
- 2009-02-13 CL CL2009000326A patent/CL2009000326A1/es unknown
- 2009-02-13 AR ARP090100515A patent/AR070375A1/es not_active Application Discontinuation
- 2009-02-13 PA PA20098816001A patent/PA8816001A1/es unknown
- 2009-02-13 TW TW098104745A patent/TW200940095A/zh unknown
- 2009-02-13 UY UY031660A patent/UY31660A1/es not_active Application Discontinuation
- 2009-02-13 PE PE2009000219A patent/PE20091471A1/es not_active Application Discontinuation
-
2010
- 2010-06-27 IL IL206640A patent/IL206640A0/en unknown
- 2010-06-30 TN TN2010000302A patent/TN2010000302A1/fr unknown
- 2010-08-12 EC EC2010010400A patent/ECSP10010400A/es unknown
- 2010-08-12 MA MA33078A patent/MA32073B1/fr unknown
- 2010-08-13 CO CO10100017A patent/CO6290633A2/es not_active Application Discontinuation
- 2010-08-13 DO DO2010000252A patent/DOP2010000252A/es unknown
- 2010-08-13 CR CR11632A patent/CR11632A/es not_active Application Discontinuation
- 2010-09-10 ZA ZA2010/06517A patent/ZA201006517B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2011511823A (ja) | 2011-04-14 |
| CA2714340A1 (en) | 2009-08-20 |
| BRPI0908477A2 (pt) | 2018-03-27 |
| AR070375A1 (es) | 2010-03-31 |
| AU2009214193A1 (en) | 2009-08-20 |
| MX2010008940A (es) | 2010-10-05 |
| CL2009000326A1 (es) | 2010-07-19 |
| ZA201006517B (en) | 2014-02-26 |
| TN2010000302A1 (en) | 2011-11-11 |
| US20110097405A1 (en) | 2011-04-28 |
| EP2249803A2 (en) | 2010-11-17 |
| IL206640A0 (en) | 2010-12-30 |
| EA201001245A1 (ru) | 2011-04-29 |
| TW200940095A (en) | 2009-10-01 |
| CR11632A (es) | 2010-10-05 |
| KR20100125309A (ko) | 2010-11-30 |
| WO2009101021A3 (en) | 2009-12-30 |
| UA102680C2 (ru) | 2013-08-12 |
| PA8816001A1 (es) | 2009-09-17 |
| WO2009101021A2 (en) | 2009-08-20 |
| CN101945646A (zh) | 2011-01-12 |
| MA32073B1 (fr) | 2011-02-01 |
| UY31660A1 (es) | 2009-09-30 |
| DOP2010000252A (es) | 2010-08-31 |
| CO6290633A2 (es) | 2011-06-20 |
| ECSP10010400A (es) | 2010-09-30 |
| PE20091471A1 (es) | 2009-10-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 3 YEARS UNTIL 05 FEB 2016 BY CPA GLOBAL Effective date: 20130117 |
|
| ASS | Change of ownership |
Owner name: BAYER INTELLECTUAL PROPERTY GMBH, DE Effective date: 20140410 |
|
| LAPS | Patent lapsed |