NZ553809A - Use of polypeptides obtained through systematic mutations of single amino acids of human and non-human box-A of HMGB1 to prevent and/or antagonize pathologies induced by HMGB1 - Google Patents
Use of polypeptides obtained through systematic mutations of single amino acids of human and non-human box-A of HMGB1 to prevent and/or antagonize pathologies induced by HMGB1Info
- Publication number
- NZ553809A NZ553809A NZ553809A NZ55380905A NZ553809A NZ 553809 A NZ553809 A NZ 553809A NZ 553809 A NZ553809 A NZ 553809A NZ 55380905 A NZ55380905 A NZ 55380905A NZ 553809 A NZ553809 A NZ 553809A
- Authority
- NZ
- New Zealand
- Prior art keywords
- hmgb1
- polypeptide variant
- box
- wild type
- hmgb1 box
- Prior art date
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- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
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| Application Number | Priority Date | Filing Date | Title |
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| EP04425665 | 2004-09-03 | ||
| PCT/EP2005/009528 WO2006024547A2 (en) | 2004-09-03 | 2005-09-05 | Protease resistant human and non-human hmgb1 box-a mutants and their therapeutic/diagnostic use |
Publications (1)
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| NZ553809A true NZ553809A (en) | 2010-03-26 |
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| NZ553809A NZ553809A (en) | 2004-09-03 | 2005-09-05 | Use of polypeptides obtained through systematic mutations of single amino acids of human and non-human box-A of HMGB1 to prevent and/or antagonize pathologies induced by HMGB1 |
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| EP (1) | EP1797118A2 (https=) |
| JP (1) | JP5622351B2 (https=) |
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| MX (1) | MX2007002557A (https=) |
| NZ (1) | NZ553809A (https=) |
| WO (1) | WO2006024547A2 (https=) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US6303321B1 (en) | 1999-02-11 | 2001-10-16 | North Shore-Long Island Jewish Research Institute | Methods for diagnosing sepsis |
| US7304034B2 (en) | 2001-05-15 | 2007-12-04 | The Feinstein Institute For Medical Research | Use of HMGB fragments as anti-inflammatory agents |
| US7647184B2 (en) | 2001-08-27 | 2010-01-12 | Hanall Pharmaceuticals, Co. Ltd | High throughput directed evolution by rational mutagenesis |
| DE60332358D1 (de) | 2002-09-09 | 2010-06-10 | Hanall Pharmaceutical Co Ltd | Protease-resistente modifizierte interferon alpha polypeptide |
| US7696169B2 (en) | 2003-06-06 | 2010-04-13 | The Feinstein Institute For Medical Research | Inhibitors of the interaction between HMGB polypeptides and toll-like receptor 2 as anti-inflammatory agents |
| CA2882022A1 (en) | 2003-09-11 | 2005-03-24 | Walter Newman | Monoclonal antibodies against hmgb1 |
| US7998930B2 (en) | 2004-11-04 | 2011-08-16 | Hanall Biopharma Co., Ltd. | Modified growth hormones |
| WO2006124477A2 (en) * | 2005-05-13 | 2006-11-23 | The Feinstein Institute For Medical Research | Combination therapy with inhibitors of hmgb and caspase for the treatment of inflammatory diseases |
| WO2007011606A2 (en) * | 2005-07-18 | 2007-01-25 | Critical Therapeutics, Inc. | USE OF HMGBl ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY SKIN CONDITIONS |
| EP2423305A1 (en) | 2006-06-19 | 2012-02-29 | Catalyst Biosciences, Inc. | Modified coagulation factor IX polypeptides and use thereof for treatment |
| WO2007149567A2 (en) | 2006-06-21 | 2007-12-27 | Musc Foundation For Research Development | Targeting complement factor h for treatment of diseases |
| AU2007296843C1 (en) | 2006-09-15 | 2012-08-16 | Creabilis Therapeutics S.P.A. | Polymer conjugates of Box-A of HMGB1 and Box-A variants of HMGB1 |
| DE602007013919D1 (de) * | 2006-09-15 | 2011-05-26 | Creabilis Therapeutics Spa | Polymerkonjugate von box-a von hmgb1 und box-a-varianten von hmgb1 |
| ES2654542T3 (es) | 2008-04-30 | 2018-02-14 | Genomix Co., Ltd. | Procedimiento de recolección de células funcionales in vivo con alta eficiencia |
| US20120165244A1 (en) * | 2008-10-30 | 2012-06-28 | Hua-Lin Wu | Methods for binding lewis y antigen |
| JP5871798B2 (ja) | 2009-07-02 | 2016-03-01 | エムユーエスシー ファウンデーション フォー リサーチ ディベロップメント | 肝再生を刺激する方法 |
| EP2492281B1 (en) * | 2009-10-19 | 2018-04-11 | HanAll Biopharma Co., Ltd. | Modified human tumor necrosis factor receptor-1 polypeptide or fragment thereof, and method for preparing same |
| US11191786B2 (en) | 2009-10-28 | 2021-12-07 | StemRIM Inc. | Agents for promoting tissue regeneration by recruiting bone marrow mesenchymal stem cells and/or pluripotent stem cells into blood |
| MX2012005151A (es) | 2009-11-05 | 2012-08-23 | Federico Ii University Of Naples | Tratamiento de hemoglobinuria nocturna paroxismica, anemias hemoliticas y estados de enfermedad que involucran hemolisis intravascular y extravascular. |
| WO2011143637A1 (en) | 2010-05-14 | 2011-11-17 | The Regents Of The University Of Colorado, A Body Corporate | Improved complement receptor 2 (cr2) targeting groups |
| US9815890B2 (en) | 2010-06-22 | 2017-11-14 | The Regents Of The University Of Colorado, A Body Corporate | Antibodies to the C3d fragment of complement component 3 |
| US10272040B2 (en) | 2010-08-12 | 2019-04-30 | Nanyang Technological University | Liposomal formulation for ocular drug delivery |
| KR101279641B1 (ko) * | 2011-01-05 | 2013-06-27 | 인하대학교 산학협력단 | Ｈｉｈｐ－２를 유효성분으로 함유하는 신경보호용 조성물 |
| EP2703487B1 (en) * | 2011-04-26 | 2018-06-27 | Genomix Co., Ltd. | Peptide for inducing regeneration of tissue and use thereof |
| WO2012170742A2 (en) | 2011-06-07 | 2012-12-13 | University Of Hawaii | Treatment and prevention of cancer with hmgb1 antagonists |
| US9244074B2 (en) | 2011-06-07 | 2016-01-26 | University Of Hawaii | Biomarker of asbestos exposure and mesothelioma |
| AU2013302441B2 (en) | 2012-08-17 | 2018-05-10 | The Regents Of The University Of Colorado, A Body Corporate | Compositions and methods for detecting complement activation |
| US10413620B2 (en) | 2012-08-17 | 2019-09-17 | The Regents Of The University Of Colorado, A Body Corporate | Light-emitting versions of the monoclonal antibody to C3D (MAB 3D29) for imaging |
| DK2913059T3 (en) | 2012-10-25 | 2018-06-25 | Genomix Co Ltd | Hitherto UNKNOWN PROCEDURE FOR TREATMENT OF SPINE INJURY USING HMGB1 FRAGMENT |
| AU2013335684B2 (en) | 2012-10-25 | 2017-06-29 | Osaka University | Novel method for treating cardiac infarction using HMGB1 fragment |
| US9956195B2 (en) * | 2014-01-07 | 2018-05-01 | Nanyang Technological University | Stable liposomal formulations for ocular drug delivery |
| GB201508337D0 (en) | 2015-05-15 | 2015-06-24 | Hmgbiotech S R L | Novel peptides |
| AU2016366515A1 (en) | 2015-12-11 | 2018-06-21 | Ruprecht-Karls-Universität Heidelberg | Combined preparations of PKM2 modulators and HMGB1 |
| US11969459B2 (en) | 2017-01-27 | 2024-04-30 | StemRIM Inc. | Therapeutic agent for cardiomyopathy, old myocardial infarction and chronic heart failure |
| AU2018257071B2 (en) * | 2017-04-25 | 2021-11-11 | Shionogi & Co., Ltd. | Peptide for inducing regeneration of tissue, and use thereof |
| CA3084013A1 (en) | 2017-12-01 | 2019-06-06 | StemRIM Inc. | Ectodermal mesenchymal stem cells and method for producing same |
| WO2019107530A1 (ja) * | 2017-12-01 | 2019-06-06 | 株式会社ステムリム | 炎症性腸疾患の治療薬 |
| WO2019156137A1 (ja) | 2018-02-08 | 2019-08-15 | 株式会社ステムリム | 乾癬の治療薬 |
| US12304933B2 (en) | 2018-10-05 | 2025-05-20 | StemRIM Inc. | Disease treatment drug based on mesenchymal-stem-cell mobilization |
| WO2020085506A1 (ja) * | 2018-10-25 | 2020-04-30 | 国立大学法人大阪大学 | 軟骨疾患の治療薬 |
| US11684653B2 (en) * | 2019-03-06 | 2023-06-27 | The Cleveland Clinic Foundation | Compositions and method for reducing virulence of microorganisms |
| JP7455433B2 (ja) * | 2020-04-22 | 2024-03-26 | チュラーロンコーン ユニバーシティー | Ｄｎａを回復する及びｄｎａ損傷を防止する組成物及び方法 |
| CN113151329B (zh) * | 2021-03-30 | 2023-09-08 | 云南师范大学 | 中性蛋白酶突变体及其构造方法和应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6303321B1 (en) * | 1999-02-11 | 2001-10-16 | North Shore-Long Island Jewish Research Institute | Methods for diagnosing sepsis |
| US7754217B2 (en) * | 2001-03-16 | 2010-07-13 | Bio3 Research Srl | HMGB1 protein inhibitors and/or antagonists for the treatment of vascular diseases |
| US7304034B2 (en) * | 2001-05-15 | 2007-12-04 | The Feinstein Institute For Medical Research | Use of HMGB fragments as anti-inflammatory agents |
| EP1392844A4 (en) * | 2001-05-15 | 2006-09-06 | Long Island Jewish Res Inst | USE OF HMG FRAGMENTS AS ANTI-INFLAMMATORY AGENTS |
| US20060204537A1 (en) * | 2002-06-21 | 2006-09-14 | Genzyme Corporation | Silicone blends and composites for drug delivery |
| EP1539950A1 (en) * | 2002-09-09 | 2005-06-15 | Nautilus Biotech | Rational directed protein evolution using two-dimensional rational mutagenesis scanning |
| PL376169A1 (en) * | 2002-11-15 | 2005-12-27 | Novartis Ag | Drug delivery system |
| CA2506328A1 (en) * | 2002-11-20 | 2004-06-03 | Critical Therapeutics, Inc. | Use of hmgb fragments as anti-inflammatory agents |
| JP2004222953A (ja) * | 2003-01-22 | 2004-08-12 | Kanegafuchi Chem Ind Co Ltd | 生体留置用ステント |
| CH694905A5 (it) * | 2003-03-25 | 2005-09-15 | Marco Ostini | Peptidi derivati dalla proteina HMGB1 per l'immunoterapia attiva nell'infiammazione sistematica letale. |
| WO2005025604A2 (en) * | 2003-09-10 | 2005-03-24 | The General Hospital Corporation | Use of hmgb and hmgb fragments to decrease specific immune response |
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2005
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- 2005-09-05 KR KR1020077007416A patent/KR101249287B1/ko not_active Expired - Fee Related
- 2005-09-05 MX MX2007002557A patent/MX2007002557A/es unknown
- 2005-09-05 CA CA2579094A patent/CA2579094C/en not_active Expired - Fee Related
- 2005-09-05 AU AU2005279308A patent/AU2005279308B2/en not_active Ceased
- 2005-09-05 BR BRPI0514835-9A patent/BRPI0514835A/pt not_active Application Discontinuation
- 2005-09-05 JP JP2007528791A patent/JP5622351B2/ja not_active Expired - Fee Related
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- 2005-09-05 WO PCT/EP2005/009528 patent/WO2006024547A2/en not_active Ceased
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2007
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2009
- 2009-11-09 US US12/614,805 patent/US8058232B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA2579094A1 (en) | 2006-03-09 |
| US20080038309A1 (en) | 2008-02-14 |
| KR20070059128A (ko) | 2007-06-11 |
| MX2007002557A (es) | 2007-10-10 |
| AU2005279308B2 (en) | 2012-05-03 |
| JP5622351B2 (ja) | 2014-11-12 |
| US7635679B2 (en) | 2009-12-22 |
| WO2006024547A3 (en) | 2006-06-01 |
| BRPI0514835A (pt) | 2008-06-24 |
| JP2008511300A (ja) | 2008-04-17 |
| CA2579094C (en) | 2014-12-02 |
| EP1797118A2 (en) | 2007-06-20 |
| US8058232B2 (en) | 2011-11-15 |
| AU2005279308A1 (en) | 2006-03-09 |
| US20110052493A1 (en) | 2011-03-03 |
| KR101249287B1 (ko) | 2013-04-01 |
| WO2006024547A2 (en) | 2006-03-09 |
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