JP5622351B2 - プロテアーゼ抵抗性ヒトおよび非ヒトＨＭＧＢ１Ｂｏｘ−Ａ変異体、ならびにそれらの治療／診断への使用 - Google Patents
プロテアーゼ抵抗性ヒトおよび非ヒトＨＭＧＢ１Ｂｏｘ−Ａ変異体、ならびにそれらの治療／診断への使用 Download PDFInfo
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- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04425665 | 2004-09-03 | ||
| EP04425665.9 | 2004-09-03 | ||
| PCT/EP2005/009528 WO2006024547A2 (en) | 2004-09-03 | 2005-09-05 | Protease resistant human and non-human hmgb1 box-a mutants and their therapeutic/diagnostic use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008511300A JP2008511300A (ja) | 2008-04-17 |
| JP2008511300A5 JP2008511300A5 (https=) | 2011-10-13 |
| JP5622351B2 true JP5622351B2 (ja) | 2014-11-12 |
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| Application Number | Title | Priority Date | Filing Date |
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| JP2007528791A Expired - Fee Related JP5622351B2 (ja) | 2004-09-03 | 2005-09-05 | プロテアーゼ抵抗性ヒトおよび非ヒトＨＭＧＢ１Ｂｏｘ−Ａ変異体、ならびにそれらの治療／診断への使用 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US7635679B2 (https=) |
| EP (1) | EP1797118A2 (https=) |
| JP (1) | JP5622351B2 (https=) |
| KR (1) | KR101249287B1 (https=) |
| AU (1) | AU2005279308B2 (https=) |
| BR (1) | BRPI0514835A (https=) |
| CA (1) | CA2579094C (https=) |
| MX (1) | MX2007002557A (https=) |
| NZ (1) | NZ553809A (https=) |
| WO (1) | WO2006024547A2 (https=) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6303321B1 (en) | 1999-02-11 | 2001-10-16 | North Shore-Long Island Jewish Research Institute | Methods for diagnosing sepsis |
| US7304034B2 (en) | 2001-05-15 | 2007-12-04 | The Feinstein Institute For Medical Research | Use of HMGB fragments as anti-inflammatory agents |
| US7647184B2 (en) | 2001-08-27 | 2010-01-12 | Hanall Pharmaceuticals, Co. Ltd | High throughput directed evolution by rational mutagenesis |
| DE60332358D1 (de) | 2002-09-09 | 2010-06-10 | Hanall Pharmaceutical Co Ltd | Protease-resistente modifizierte interferon alpha polypeptide |
| US7696169B2 (en) | 2003-06-06 | 2010-04-13 | The Feinstein Institute For Medical Research | Inhibitors of the interaction between HMGB polypeptides and toll-like receptor 2 as anti-inflammatory agents |
| AU2004272607B2 (en) | 2003-09-11 | 2008-11-06 | Cornerstone Therapeutics Inc. | Monoclonal antibodies against HMGB1 |
| US7998930B2 (en) | 2004-11-04 | 2011-08-16 | Hanall Biopharma Co., Ltd. | Modified growth hormones |
| WO2006124477A2 (en) * | 2005-05-13 | 2006-11-23 | The Feinstein Institute For Medical Research | Combination therapy with inhibitors of hmgb and caspase for the treatment of inflammatory diseases |
| WO2007011606A2 (en) * | 2005-07-18 | 2007-01-25 | Critical Therapeutics, Inc. | USE OF HMGBl ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY SKIN CONDITIONS |
| EP2423307A1 (en) | 2006-06-19 | 2012-02-29 | Catalyst Biosciences, Inc. | Modified coagulation factor IV polypeptides and use thereof for treatment |
| US7759304B2 (en) | 2006-06-21 | 2010-07-20 | Regents Of The University Of Colorado | Targeting complement factor H for treatment of diseases |
| CA2663300C (en) * | 2006-09-15 | 2014-10-07 | Creabilis Therapeutics S.P.A. | Polymer conjugates of box-a of hmgb1 and box-a variants of hmgb1 |
| BRPI0718491A2 (pt) * | 2006-09-15 | 2013-12-03 | Creabilis Therapeutics Spa | Conjugados poliméricos do box-a da hmgb1 e variantes do box-a da hmbg1 |
| JP5676253B2 (ja) | 2008-04-30 | 2015-02-25 | 株式会社ジェノミックス | 生体内機能的細胞の高効率採取法 |
| US20120165244A1 (en) * | 2008-10-30 | 2012-06-28 | Hua-Lin Wu | Methods for binding lewis y antigen |
| WO2011003098A1 (en) | 2009-07-02 | 2011-01-06 | Musc Foundation For Research Development | Methods of stimulating liver regeneration |
| EP2492281B1 (en) * | 2009-10-19 | 2018-04-11 | HanAll Biopharma Co., Ltd. | Modified human tumor necrosis factor receptor-1 polypeptide or fragment thereof, and method for preparing same |
| JP5865703B2 (ja) | 2009-10-28 | 2016-02-17 | 株式会社ジェノミックス | 骨髄間葉系および／または多能性幹細胞の血中動員による組織再生促進剤 |
| CA2795311A1 (en) | 2009-11-05 | 2011-05-12 | Taligen Therapeutics, Inc. | Treatment of paroxysmal nocturnal hemoglobinuria, hemolytic anemias and disease states involving intravascular and extravascular hemolysis |
| BR112012029067A2 (pt) | 2010-05-14 | 2019-09-24 | Univ Colorado Regents | grupos-alvo de receptor do complemento 2 (cr2) melhorados. |
| SG186397A1 (en) | 2010-06-22 | 2013-01-30 | Univ Colorado Regents | Antibodies to the c3d fragment of complement component 3 |
| SG187770A1 (en) | 2010-08-12 | 2013-03-28 | Univ Nanyang Tech | A liposomal formulation for ocular drug delivery |
| KR101279641B1 (ko) * | 2011-01-05 | 2013-06-27 | 인하대학교 산학협력단 | Ｈｉｈｐ－２를 유효성분으로 함유하는 신경보호용 조성물 |
| PT3358011T (pt) * | 2011-04-26 | 2020-04-23 | Univ Osaka | Péptido para induzir a regeneração de um tecido e a sua utilização |
| WO2012170742A2 (en) | 2011-06-07 | 2012-12-13 | University Of Hawaii | Treatment and prevention of cancer with hmgb1 antagonists |
| US9244074B2 (en) | 2011-06-07 | 2016-01-26 | University Of Hawaii | Biomarker of asbestos exposure and mesothelioma |
| US10413620B2 (en) | 2012-08-17 | 2019-09-17 | The Regents Of The University Of Colorado, A Body Corporate | Light-emitting versions of the monoclonal antibody to C3D (MAB 3D29) for imaging |
| JP2015535212A (ja) | 2012-08-17 | 2015-12-10 | ザ・リージエンツ・オブ・ザ・ユニバーシテイ・オブ・コロラド、ア・ボデイー・コーポレイト | 補体活性化を検出するための組成物および方法 |
| US9688733B2 (en) | 2012-10-25 | 2017-06-27 | Genomix Co., Ltd. | Method for treating spinal cord injury using HMGB1 fragment |
| ES2660420T3 (es) | 2012-10-25 | 2018-03-22 | Genomix Co., Ltd. | Método novedoso para tratar infarto cardiaco utilizando fragmento de HMGB1 |
| US9956195B2 (en) * | 2014-01-07 | 2018-05-01 | Nanyang Technological University | Stable liposomal formulations for ocular drug delivery |
| GB201508337D0 (en) | 2015-05-15 | 2015-06-24 | Hmgbiotech S R L | Novel peptides |
| CN108367049A (zh) | 2015-12-11 | 2018-08-03 | 海德堡吕布莱希特-卡尔斯大学 | Pkm2调节剂和hmgb1的组合制剂 |
| EP3556378B1 (en) | 2017-01-27 | 2025-03-12 | StemRIM Inc. | Therapeutic agent for cardiomyopathy, old myocardial infarction and chronic heart failure |
| CA3059544A1 (en) * | 2017-04-25 | 2018-11-01 | Shionogi & Co., Ltd. | Peptide for inducing regeneration of tissue, and use thereof |
| CN111868231B (zh) | 2017-12-01 | 2024-05-31 | 斯特姆里姆有限公司 | 外胚层间充质干细胞及其产生方法 |
| CN111542335A (zh) * | 2017-12-01 | 2020-08-14 | 斯特姆里姆有限公司 | 炎症性肠病的治疗药 |
| US20210024594A1 (en) | 2018-02-08 | 2021-01-28 | StemRIM Inc. | Therapeutic Agent for Psoriasis |
| US12304933B2 (en) | 2018-10-05 | 2025-05-20 | StemRIM Inc. | Disease treatment drug based on mesenchymal-stem-cell mobilization |
| CA3117107A1 (en) * | 2018-10-25 | 2020-04-30 | Osaka University | Therapeutic agent for cartilage disorder |
| US11684653B2 (en) * | 2019-03-06 | 2023-06-27 | The Cleveland Clinic Foundation | Compositions and method for reducing virulence of microorganisms |
| US20250019405A1 (en) * | 2020-04-22 | 2025-01-16 | Chulalongkorn University | A Composition and A Method of Rejuvenating DNA and Preventing DNA Damage |
| CN113151329B (zh) * | 2021-03-30 | 2023-09-08 | 云南师范大学 | 中性蛋白酶突变体及其构造方法和应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6303321B1 (en) * | 1999-02-11 | 2001-10-16 | North Shore-Long Island Jewish Research Institute | Methods for diagnosing sepsis |
| US7754217B2 (en) * | 2001-03-16 | 2010-07-13 | Bio3 Research Srl | HMGB1 protein inhibitors and/or antagonists for the treatment of vascular diseases |
| US7304034B2 (en) * | 2001-05-15 | 2007-12-04 | The Feinstein Institute For Medical Research | Use of HMGB fragments as anti-inflammatory agents |
| CN100447154C (zh) * | 2001-05-15 | 2008-12-31 | 费因斯坦医学研究学院 | 利用hmg片段作为抗炎症试剂 |
| JP2005530561A (ja) * | 2002-06-21 | 2005-10-13 | ジェンズィム コーポレーション | 薬剤送達用シリコーン混合物及び複合体 |
| AU2003267700A1 (en) * | 2002-09-09 | 2004-03-29 | Nautilus Biotech | Rational directed protein evolution using two-dimensional rational mutagenesis scanning |
| JP2006522007A (ja) * | 2002-11-15 | 2006-09-28 | ノバルティス アクチエンゲゼルシャフト | ドラッグ・デリバリー・システム |
| JP2006510619A (ja) * | 2002-11-20 | 2006-03-30 | クリティカル セラピューティクス，インコーポレイテッド | 抗炎症剤としてのｈｍｇｂ断片の使用 |
| JP2004222953A (ja) * | 2003-01-22 | 2004-08-12 | Kanegafuchi Chem Ind Co Ltd | 生体留置用ステント |
| CH694905A5 (it) * | 2003-03-25 | 2005-09-15 | Marco Ostini | Peptidi derivati dalla proteina HMGB1 per l'immunoterapia attiva nell'infiammazione sistematica letale. |
| WO2005025604A2 (en) * | 2003-09-10 | 2005-03-24 | The General Hospital Corporation | Use of hmgb and hmgb fragments to decrease specific immune response |
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2005
- 2005-09-05 JP JP2007528791A patent/JP5622351B2/ja not_active Expired - Fee Related
- 2005-09-05 EP EP05790365A patent/EP1797118A2/en not_active Ceased
- 2005-09-05 CA CA2579094A patent/CA2579094C/en not_active Expired - Fee Related
- 2005-09-05 WO PCT/EP2005/009528 patent/WO2006024547A2/en not_active Ceased
- 2005-09-05 KR KR1020077007416A patent/KR101249287B1/ko not_active Expired - Fee Related
- 2005-09-05 MX MX2007002557A patent/MX2007002557A/es unknown
- 2005-09-05 NZ NZ553809A patent/NZ553809A/en not_active IP Right Cessation
- 2005-09-05 BR BRPI0514835-9A patent/BRPI0514835A/pt not_active Application Discontinuation
- 2005-09-05 AU AU2005279308A patent/AU2005279308B2/en not_active Ceased
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Also Published As
| Publication number | Publication date |
|---|---|
| KR101249287B1 (ko) | 2013-04-01 |
| US7635679B2 (en) | 2009-12-22 |
| AU2005279308B2 (en) | 2012-05-03 |
| CA2579094A1 (en) | 2006-03-09 |
| JP2008511300A (ja) | 2008-04-17 |
| CA2579094C (en) | 2014-12-02 |
| US20080038309A1 (en) | 2008-02-14 |
| NZ553809A (en) | 2010-03-26 |
| WO2006024547A3 (en) | 2006-06-01 |
| WO2006024547A2 (en) | 2006-03-09 |
| BRPI0514835A (pt) | 2008-06-24 |
| AU2005279308A1 (en) | 2006-03-09 |
| US20110052493A1 (en) | 2011-03-03 |
| EP1797118A2 (en) | 2007-06-20 |
| US8058232B2 (en) | 2011-11-15 |
| MX2007002557A (es) | 2007-10-10 |
| KR20070059128A (ko) | 2007-06-11 |
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