NZ553273A - Treating gliosis, glial scarring, inflammation or inhibition of a xonal growth in the nervous system with an antagonist of EphA4-mediated signalling - Google Patents

Treating gliosis, glial scarring, inflammation or inhibition of a xonal growth in the nervous system with an antagonist of EphA4-mediated signalling

Info

Publication number
NZ553273A
NZ553273A NZ553273A NZ55327305A NZ553273A NZ 553273 A NZ553273 A NZ 553273A NZ 553273 A NZ553273 A NZ 553273A NZ 55327305 A NZ55327305 A NZ 55327305A NZ 553273 A NZ553273 A NZ 553273A
Authority
NZ
New Zealand
Prior art keywords
epha4
nervous system
antagonist
gliosis
molecule
Prior art date
Application number
NZ553273A
Other languages
English (en)
Inventor
Perry F Bartlett
Mary P Galea
Ann M Turnley
Yona Goldshmit
Andrew W Boyd
Original Assignee
Univ Melbourne
Univ Queensland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2004905148A external-priority patent/AU2004905148A0/en
Application filed by Univ Melbourne, Univ Queensland filed Critical Univ Melbourne
Publication of NZ553273A publication Critical patent/NZ553273A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/7105Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
NZ553273A 2004-09-08 2005-09-08 Treating gliosis, glial scarring, inflammation or inhibition of a xonal growth in the nervous system with an antagonist of EphA4-mediated signalling NZ553273A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2004905148A AU2004905148A0 (en) 2004-09-08 A method of treatment and agents useful for same
US64796805P 2005-01-27 2005-01-27
PCT/AU2005/001363 WO2006026820A1 (en) 2004-09-08 2005-09-08 Treating gliosis, glial scarring, inflammation or inhibition of axonal growth in the nervous system by modulating eph receptor

Publications (1)

Publication Number Publication Date
NZ553273A true NZ553273A (en) 2009-11-27

Family

ID=36036018

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ553273A NZ553273A (en) 2004-09-08 2005-09-08 Treating gliosis, glial scarring, inflammation or inhibition of a xonal growth in the nervous system with an antagonist of EphA4-mediated signalling

Country Status (6)

Country Link
US (1) US20080254023A1 (en:Method)
EP (1) EP1793854A4 (en:Method)
JP (2) JP5094395B2 (en:Method)
CA (1) CA2579352A1 (en:Method)
NZ (1) NZ553273A (en:Method)
WO (1) WO2006026820A1 (en:Method)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPP674898A0 (en) 1998-10-27 1998-11-19 Walter And Eliza Hall Institute Of Medical Research, The A method of treatment
NZ553273A (en) * 2004-09-08 2009-11-27 Univ Melbourne Treating gliosis, glial scarring, inflammation or inhibition of a xonal growth in the nervous system with an antagonist of EphA4-mediated signalling
KR20090029261A (ko) * 2006-07-13 2009-03-20 노파르티스 아게 신경계 장애의 치료에서의 트리플루오로메틸-치환 벤즈아미드의 용도
US8530181B2 (en) 2007-11-15 2013-09-10 Eisai R&D Management Co., Ltd. Method of screening for compounds which affect the cleavage of EphA7 byγ-secretase
JP5508857B2 (ja) * 2007-11-30 2014-06-04 エーザイ・アール・アンド・ディー・マネジメント株式会社 新規活性を有するEphA4ポリペプチドおよびその用途
EP2260864A1 (en) * 2009-06-10 2010-12-15 University of Melbourne Therapeutic applications
DK2653552T3 (en) 2010-12-17 2017-01-16 Eisai R&D Man Co Ltd SCREENING METHOD USING GELATINASE-MEDIATED EphA4 DIVISION REACTION AS INDICATOR
US9784751B2 (en) 2011-04-25 2017-10-10 Eisai R&D Management Co., Ltd. Method for detecting neurological disease associated with cognitive impairment by measuring EphA4 extracellular domain
WO2016011201A2 (en) * 2014-07-15 2016-01-21 Sanford Burnham Prebys Medical Discovery Institute Epha4 cyclic peptide antagonists for neuroprotection and neural repair
RU2651756C1 (ru) * 2017-05-10 2018-04-23 Федеральное государственное бюджетное образовательное учреждение Высшего Образования Кубанский Государственный Медицинский Университет Министерства Здравоохранения Российской Федерации, КубГМУ Препарат для предотвращения образования глиальных рубцов
MY207780A (en) 2019-07-01 2025-03-18 Eisai R&D Man Co Ltd Anti-epha4 antibody

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPP674898A0 (en) * 1998-10-27 1998-11-19 Walter And Eliza Hall Institute Of Medical Research, The A method of treatment
AU766077C (en) * 1998-11-20 2004-10-07 Genentech Inc. Uses for Eph receptor antagonists and agonists to treat vascular disorders
WO2004028551A1 (en) * 2002-09-24 2004-04-08 The Burnham Institute Novel agents that modulate eph receptor activity
WO2004041197A2 (en) * 2002-11-01 2004-05-21 Case Western Reserve University Methods of inhibiting glial scar formation
WO2005056766A2 (en) * 2003-12-04 2005-06-23 Medimmune, Inc. TARGETED DRUG DELIVERY USING EphA2 OR Eph4 BINDING MOIETIES
NZ553273A (en) * 2004-09-08 2009-11-27 Univ Melbourne Treating gliosis, glial scarring, inflammation or inhibition of a xonal growth in the nervous system with an antagonist of EphA4-mediated signalling

Also Published As

Publication number Publication date
JP2008512394A (ja) 2008-04-24
WO2006026820A1 (en) 2006-03-16
CA2579352A1 (en) 2006-03-16
US20080254023A1 (en) 2008-10-16
JP5094395B2 (ja) 2012-12-12
WO2006026820A9 (en) 2007-04-05
EP1793854A1 (en) 2007-06-13
JP2012136529A (ja) 2012-07-19
EP1793854A4 (en) 2008-01-02

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Legal Events

Date Code Title Description
RENW Renewal (renewal fees accepted)
PSEA Patent sealed
RENW Renewal (renewal fees accepted)
LAPS Patent lapsed