NZ528681A - Compositions comprising (-)-hydroxycitric acid (HCA), chromium and gymnemic acid to increase serotonin levels and induce weight loss - Google Patents
Compositions comprising (-)-hydroxycitric acid (HCA), chromium and gymnemic acid to increase serotonin levels and induce weight lossInfo
- Publication number
- NZ528681A NZ528681A NZ528681A NZ52868102A NZ528681A NZ 528681 A NZ528681 A NZ 528681A NZ 528681 A NZ528681 A NZ 528681A NZ 52868102 A NZ52868102 A NZ 52868102A NZ 528681 A NZ528681 A NZ 528681A
- Authority
- NZ
- New Zealand
- Prior art keywords
- person
- chromium
- acid
- amount
- pharmaceutical composition
- Prior art date
Links
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 title claims abstract description 180
- ZMJBYMUCKBYSCP-UHFFFAOYSA-N (+)-Erythro-hydroxycitric acid Natural products OC(=O)C(O)C(O)(C(O)=O)CC(O)=O ZMJBYMUCKBYSCP-UHFFFAOYSA-N 0.000 title claims abstract description 101
- 229940076279 serotonin Drugs 0.000 title claims abstract description 87
- 229910052804 chromium Inorganic materials 0.000 title claims abstract description 44
- 239000011651 chromium Substances 0.000 title claims abstract description 44
- 239000000203 mixture Substances 0.000 title claims abstract description 43
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 title claims abstract description 42
- 229930183009 gymnemic acid Natural products 0.000 title claims abstract description 28
- ZMJBYMUCKBYSCP-AWFVSMACSA-N (1s,2r)-1,2-dihydroxypropane-1,2,3-tricarboxylic acid Chemical compound OC(=O)[C@@H](O)[C@@](O)(C(O)=O)CC(O)=O ZMJBYMUCKBYSCP-AWFVSMACSA-N 0.000 title claims abstract description 27
- 230000004580 weight loss Effects 0.000 title description 2
- 230000001965 increasing effect Effects 0.000 claims abstract description 25
- 241000208253 Gymnema sylvestre Species 0.000 claims abstract description 16
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims abstract description 16
- 239000011664 nicotinic acid Substances 0.000 claims abstract description 16
- 229960003512 nicotinic acid Drugs 0.000 claims abstract description 16
- 235000001968 nicotinic acid Nutrition 0.000 claims abstract description 16
- 235000013305 food Nutrition 0.000 claims abstract description 14
- 241000593508 Garcinia Species 0.000 claims abstract description 10
- 235000000885 Garcinia xanthochymus Nutrition 0.000 claims abstract description 10
- 230000037396 body weight Effects 0.000 claims abstract description 10
- 230000002950 deficient Effects 0.000 claims abstract description 5
- 208000019022 Mood disease Diseases 0.000 claims description 7
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- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 claims description 6
- 230000007423 decrease Effects 0.000 claims description 6
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- 235000012054 meals Nutrition 0.000 claims description 6
- 208000019901 Anxiety disease Diseases 0.000 claims description 4
- 208000032841 Bulimia Diseases 0.000 claims description 4
- 235000013361 beverage Nutrition 0.000 claims description 4
- 239000007788 liquid Substances 0.000 claims description 4
- 230000036506 anxiety Effects 0.000 claims description 3
- 239000002775 capsule Substances 0.000 claims description 3
- 239000007937 lozenge Substances 0.000 claims description 3
- 239000006187 pill Substances 0.000 claims description 3
- 239000000843 powder Substances 0.000 claims description 3
- 239000003826 tablet Substances 0.000 claims description 3
- 206010004716 Binge eating Diseases 0.000 claims description 2
- 206010013954 Dysphoria Diseases 0.000 claims description 2
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 claims description 2
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- 238000002360 preparation method Methods 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 14
- 229940089491 hydroxycitric acid Drugs 0.000 abstract description 69
- 238000000034 method Methods 0.000 abstract description 29
- 210000002966 serum Anatomy 0.000 abstract description 11
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- YZCKVEUIGOORGS-NJFSPNSNSA-N Tritium Chemical compound [3H] YZCKVEUIGOORGS-NJFSPNSNSA-N 0.000 description 6
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- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 4
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- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 2
- 229940123685 Monoamine oxidase inhibitor Drugs 0.000 description 2
- 206010067482 No adverse event Diseases 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- ZSLZBFCDCINBPY-ZSJPKINUSA-N acetyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 ZSLZBFCDCINBPY-ZSJPKINUSA-N 0.000 description 2
- 238000000540 analysis of variance Methods 0.000 description 2
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- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 150000001844 chromium Chemical class 0.000 description 2
- 206010061428 decreased appetite Diseases 0.000 description 2
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- 230000007246 mechanism Effects 0.000 description 2
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- 239000002858 neurotransmitter agent Substances 0.000 description 2
- 239000001103 potassium chloride Substances 0.000 description 2
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- RTHCYVBBDHJXIQ-MRXNPFEDSA-N (R)-fluoxetine Chemical compound O([C@H](CCNC)C=1C=CC=CC=1)C1=CC=C(C(F)(F)F)C=C1 RTHCYVBBDHJXIQ-MRXNPFEDSA-N 0.000 description 1
- 102000004146 ATP citrate synthases Human genes 0.000 description 1
- 108090000662 ATP citrate synthases Proteins 0.000 description 1
- 208000017194 Affective disease Diseases 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- GDLIGKIOYRNHDA-UHFFFAOYSA-N Clomipramine Chemical compound C1CC2=CC=C(Cl)C=C2N(CCCN(C)C)C2=CC=CC=C21 GDLIGKIOYRNHDA-UHFFFAOYSA-N 0.000 description 1
- 229940122204 Cyclooxygenase inhibitor Drugs 0.000 description 1
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- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 235000017309 Hypericum perforatum Nutrition 0.000 description 1
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- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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- A23L33/165—Complexes or chelates
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- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/27—Asclepiadaceae (Milkweed family), e.g. hoya
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/38—Clusiaceae, Hypericaceae or Guttiferae (Hypericum or Mangosteen family), e.g. common St. Johnswort
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Nutrition Science (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Psychiatry (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Pain & Pain Management (AREA)
- Microbiology (AREA)
- Child & Adolescent Psychology (AREA)
- Anesthesiology (AREA)
- Diabetes (AREA)
- Inorganic Chemistry (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28059301P | 2001-03-30 | 2001-03-30 | |
| US34347301P | 2001-12-20 | 2001-12-20 | |
| PCT/US2002/010368 WO2002078616A2 (en) | 2001-03-30 | 2002-04-01 | Methods for increasing serotonin levels by administering (-)-hydroxycitric acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ528681A true NZ528681A (en) | 2005-03-24 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ528681A NZ528681A (en) | 2001-03-30 | 2002-04-01 | Compositions comprising (-)-hydroxycitric acid (HCA), chromium and gymnemic acid to increase serotonin levels and induce weight loss |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP1379261A4 (ja) |
| JP (1) | JP2004526738A (ja) |
| AU (1) | AU2002305132B2 (ja) |
| CA (1) | CA2442370A1 (ja) |
| IL (1) | IL158172A0 (ja) |
| MX (1) | MXPA03008939A (ja) |
| NZ (1) | NZ528681A (ja) |
| WO (1) | WO2002078616A2 (ja) |
| ZA (1) | ZA200307594B (ja) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7927636B1 (en) | 1997-07-14 | 2011-04-19 | Interhealth Nutraceuticals, Inc. | Hydroxycitric acid compositions, pharmaceutical and dietary supplements and food products made therefrom, and methods for their use in reducing body weight |
| US7119110B2 (en) | 2001-10-05 | 2006-10-10 | Interhealth Nutraceuticals Incorporated | Method and composition for preventing or reducing the symptoms of insulin resistance syndrome |
| US20030119913A1 (en) * | 2001-12-20 | 2003-06-26 | Ohia Sunny E. | Method for increasing serotonin levels in a person by administration of a composition incorporating (-)-hydroxycitric acid, and related compositions thereof |
| US8394856B2 (en) * | 2002-07-02 | 2013-03-12 | Glykon Technologies Group, Llc | (-)-Hydroxycitric acid for controlling inflammation |
| WO2004085462A2 (en) * | 2003-03-21 | 2004-10-07 | Interhealth Nutraceuticals Incorporated | Method and composition for decreasing ghrelin levels |
| US20050215644A1 (en) * | 2004-03-19 | 2005-09-29 | Interhealth Nutraceuticals, Inc. | Methods for increasing neurotransmitter levels using hydroxycitric acid |
| WO2021247293A1 (en) * | 2020-06-02 | 2021-12-09 | Glykon Technologies Group, Llc | Methods and pharmaceutical preparations for elevating ketone utilization |
| EP4157199A4 (en) * | 2020-06-02 | 2024-06-19 | Glykon Technologies Group, LLC | METHODS AND PHARMACEUTICAL PREPARATIONS FOR INCREASING HEMOGLOBIN AND OXYGEN SATURATION LEVELS IN THE BLOOD WITH HYDROXYCITRIC ACID |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5612039A (en) * | 1994-03-14 | 1997-03-18 | Nini E. Policappelli | Dietary supplement |
| US5626849A (en) * | 1995-06-07 | 1997-05-06 | Reliv International, Inc. | Weight loss composition for burning and reducing synthesis of fats |
| IT1276253B1 (it) * | 1995-12-15 | 1997-10-27 | Sigma Tau Ind Farmaceuti | Composizione farmaceutica contenente l-carnitina o alcanoil l-carnitine per la prevenzione ed il trattamento di stati morbosi |
| AU5802499A (en) * | 1998-09-01 | 2000-03-21 | Amway Corporation | Diet composition and method of weight management |
| US6207714B1 (en) * | 1999-09-14 | 2001-03-27 | Dallas L. Clouatre | Methods and pharmaceutical preparations for improving glucose metabolism with (−)-hydroxycitric acid |
-
2002
- 2002-04-01 NZ NZ528681A patent/NZ528681A/en not_active IP Right Cessation
- 2002-04-01 JP JP2002576884A patent/JP2004526738A/ja active Pending
- 2002-04-01 MX MXPA03008939A patent/MXPA03008939A/es not_active Application Discontinuation
- 2002-04-01 CA CA002442370A patent/CA2442370A1/en not_active Abandoned
- 2002-04-01 IL IL15817202A patent/IL158172A0/xx unknown
- 2002-04-01 AU AU2002305132A patent/AU2002305132B2/en not_active Expired
- 2002-04-01 WO PCT/US2002/010368 patent/WO2002078616A2/en active IP Right Grant
- 2002-04-01 EP EP02733934A patent/EP1379261A4/en not_active Withdrawn
-
2003
- 2003-09-30 ZA ZA2003/07594A patent/ZA200307594B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL158172A0 (en) | 2004-03-28 |
| MXPA03008939A (es) | 2005-03-07 |
| ZA200307594B (en) | 2005-05-25 |
| AU2002305132B2 (en) | 2007-05-31 |
| EP1379261A4 (en) | 2004-09-08 |
| EP1379261A2 (en) | 2004-01-14 |
| CA2442370A1 (en) | 2002-10-10 |
| WO2002078616A3 (en) | 2002-11-28 |
| JP2004526738A (ja) | 2004-09-02 |
| WO2002078616A2 (en) | 2002-10-10 |
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