TW200841827A - A nutritional supplement for adjustment of blood pressure and protection of cardio-vascular and cerebro-vascular systems - Google Patents

Abstract

The invention refers to a nutritional supplement that can adjust blood pressure. The invention is made of arginine to reduce blood pressure and protect cardio vascular and cerebro-vascular systems.

Description

200841827 IX. Description of the Invention: [Technical Field] The present invention relates to a health care product, and more particularly to a health care product having an effect of regulating blood pressure and protecting a cardiovascular system and an application thereof. [Prior Art] Cardiovascular and cerebrovascular diseases, represented by hypertension, hyperlipidemia and coronary heart disease, have been seriously jeopardizing human health and are known as "the number one executioner of human health." With the improvement of people's living standards and the accelerated pace of life, there are many sub-health problems in the population. Cardiovascular and cerebrovascular diseases such as hypertension, hyperlipemia and coronary heart disease are more beneficial. According to relevant research reports, about 35% of adults and minors have different levels of hypertension, blood lipids and other cardiovascular and cerebrovascular diseases. When these conditions are not obvious or for preventive purposes or to assist in the treatment of these diseases, people are often very willing to choose health care products that are very beneficial to the body, rather than drugs that will cause some harm to the human body. Therefore, for high blood pressure or heart and brain The regulation of vascular system health products is particularly important. Nowadays, the health care products circulating in the Chinese health care products market are generally based on the traditional Chinese medicine theory based on traditional Chinese medicine theory, and only a few of these health products have a few extracts of natural plants that can clarify the active ingredients they contain. And a more precise mechanism of action; another part of the health care products are mainly chemical synthetic products and plant extracts from abroad, and these health care products lack the active ingredients based on the overall and regulation of our traditional Chinese medicine, so How to combine foreign health awareness and molecular and biological techniques with traditional Chinese traditional medicine theory to produce health care products that do not use treatment for the purpose of real regulation and protection. Become a new topic in the development of health products. SUMMARY OF THE INVENTION - The technical problem to be solved by the present invention is to combine biological research results with traditional Chinese medicine theory to provide a health care product having blood pressure regulating function and protecting cardiovascular and cerebrovascular system functions. According to the present invention there is provided a composition comprising arginine and hawthorn extract. Another composition according to the present invention 'in addition to arginine and hawthorn extract' also contains vitamin E. According to the present invention, a composition is provided in accordance with the total weight of the composition of 1000 mg, wherein arginine The content is 848-870 mg, and the content of hawthorn extract is l〇6-141 mg. 4 200841827 According to the present invention, there is provided a composition according to the total weight of the composition of 100 mg, wherein the vitamin E content is 10 to 24 mg. According to the present invention, a composition is provided in an amount of 1 mg relative to the total weight of the composition, wherein The arginine content is 850-868 mg, and the hawthorn extract content is 112-136 mg. According to the present invention, a composition is provided, wherein the step of preparing the hawthorn extract is followed by: selecting hawthorn, washing, pulverizing, dipping Extraction, filtration, concentration of the extract, wherein the concentration ratio of the extract is 5: 1 to 15 · According to the present invention, a composition is provided which is prepared as a solid dosage form by adding the corresponding excipient as an active composition. Or a liquid dosage form, wherein the solid dosage form is a tablet, a powder or a capsule. According to the present invention, any of the above compositions can be used as a health care product having a blood pressure regulating function and a cardiovascular and cerebrovascular system. According to the present invention, in any one of the above compositions, the strontium uptake amount of arginine is 500-13000 mg, and the daily intake of hawthorn extract is 604600 mg, preferably, the daily intake of arginine is 4500-6000 mg, hawthorn extract. The daily intake is 500-700 mg. The present invention mainly achieves the health care effect of lowering blood pressure and protecting the cardiovascular system by the combination of arginine and hawthorn extract. The cause of cardiovascular and cerebrovascular diseases Complex, a cardiovascular and cerebrovascular disease is often accompanied by a variety of symptoms, such as hypertension, hyperlipidemia, stroke, myocardial infarction, heart failure, coronary heart disease, etc., and because of the wide range of systems or tissues involved in blood pressure and blood lipid regulation in the body, There are many kinds of drugs in the cardiovascular and cerebrovascular diseases in the above system. This is because people have many difficulties in choosing. Even if a certain drug is selected, it is only one of the causes of this one, and it is difficult to achieve a comprehensive effect. And the composition can better solve this problem. The main role of arginine is to regulate blood pressure and regulate blood lipids, but the effect is weak, while the main effect of hawthorn is to lower blood lipids and have a certain antihypertensive effect. Therefore, the combination of the two will more comprehensively and systematically prevent and protect various diseases of the heart and brain. The specific function and mechanism of action of some of the ingredients in the composition will be explained below. Arginine is divided into L-arginine and R-arginine. L-arginine is the main producer of nitric oxide. Its molecular formula is C6HmN4〇2, and its structural formula is shown in the figure below. —NH—CHi—Caf—eHi—NHi arginine is a conditionally essential amino acid. Under normal circumstances, the demand for arginine in adults or animals can be met by endogenous synthetic pathways, but under stress conditions. The demand for arginine in the lower body is increased. In addition to being a protein-constituting amino acid, arginine plays an important role in many biological processes. Dietary supply of arginine promotes wound healing, regulates endocrine function, and enhances immune activity. Under normal unstressed conditions 5 200841827 The body's demand for arginine can be satisfied by the endogenous pathway, but it can not meet the needs of the body when stressed. For humans or animals that recover from childhood, trauma, or disease, dietary arginine is essential for optimal growth and recovery, and can be classified as a conditional essential amino acid or a semi-essential amino acid. The reason why arginine can play the above-mentioned very important role is because arginine can produce nitric oxide (NO) in the human body. L-arginine is a precursor of nitric oxide synthesis. L-arginine enters the cell through the cell membrane through the L-arginine transporter, and biosynthesizes nitric oxide under the catalysis of nitric oxide synthase in the cell. It has been found that L-arginine transporters are present in vascular endothelial cells, vascular smooth muscle cells, platelets, glial cells, glial cells, hepatocytes, small intestinal cells, and the like. There are three main metabolic pathways of L-arginine in cells: (1) Nitric oxide and L-citrulline are catalyzed by NOS: (2) Urea and L-ornithine are catalyzed by arginase: (3) Jingjing Amino acid dehydrogenase catalyzes the production of C〇2 and spermine. In addition, L-arginine can also enhance the activity of NOS. Its possible mechanism includes the induction of increased expression of nitric oxide synthase in cells; 2 the activity of nitric oxide synthase is enhanced by a feedforward mechanism. Cardiovascular regulation and protection of nitric oxide produced by arginine. Nitric oxide, as a message molecule, plays an important role in maintaining constant vascular tone and regulating blood pressure stability and inhibiting platelet adhesion and aggregation. (1) Under normal circumstances, in the cardiovascular system, the generated nitric oxide rapidly diffuses into the adjacent blood-tube smooth muscle cells, and the intracellular soluble guanylate cyclase (GT) on the ferrous protopazine Iron ions combine to form a nitric oxide-Heme-GT complex, which is initiated by a change in the conformation of the enzyme protein. GT catalyzes the conversion of guanosine triphosphate to cyclic guanosine monophosphate (cGMP), which initiates cGMP-dependent protein kinases. Cytosolic Ca2+ flows extracellularly or stores in the intracellular Ca2+ pool and inhibits Ca2+ influx, resulting in a decrease in intracellular free Ca2+ concentration, thereby inhibiting Ca27 calmodulin-mediated myosin peptide phosphorylation. Actin binding to myosin is inhibited, resulting in vascular smooth muscle relaxation and decreased blood pressure. (2) Nitric oxide acts as a neural information substance. The depolarization of the nerve impulse membrane leads to an increase in intracellular calcium ion concentration, which leads to an increase in Ca2+-dependent nitric oxide synthase activity - an increase in the amount of nitric oxide produced, which acts on vascular smooth muscle to produce a relaxing effect. Nitric oxide can also reduce the excitability of the nerves through the regulation of the action of glutamate in the nerve center to achieve the regulation of cardiovascular function. Nitric oxide can expand the tracheobronchial bronchus. Like vascular smooth muscle, nitric oxide relaxes smooth muscle by increasing cGMP by guanylate cyclase. After using the nitric oxide synthesis blocker L-NAME in guinea pigs, the whole lung resistance can be seen. Ascending, L-arg can be attenuated, indicating that nitric oxide produced by epithelial nitric oxide synthase is an important factor in controlling tracheobronchial tension. Nitric oxide is the only non-adrenergic, non-cholinergic neurotransmitter in the human respiratory system that has dilated neurological effects and may be involved in the secretion of the immune system, ciliary movement, and mucous glands. The nasal mucosa is the site that produces the most nitric oxide. Nitric oxide can regulate the blood flow of the nasal mucosa and affect the movement of the ciliary hair, thus promoting the warming and moistening action and cleaning effect of the nasal mucosa. Nitric oxide produced by the nasal cavity can reach the terminal respiratory tract, regulate mucosal blood flow, and maintain the smooth muscle tension of the respiratory tract. Endogenous nitric oxide can be inhibited by long-term smoking. After the respiratory tract is infected by 200841827 infection, in the cytokine of tumor necrosis factor, interferon, interleukin, etc., various cells in the respiratory system produce nitric oxide. It not only regulates smooth muscle tone, but also maintains the permeability of epithelial cells. Nitric oxide is a biological information transmitter. It acts as a cellular information molecule that regulates cardiovascular, neurological and immune functions. It participates in the regulation of various physiological activities of the body, and plays an important role in cardiovascular physiology and pathology. Once the occurrence of nitric oxide on the cardiovascular dysfunction, it will lead to the pathogenesis of many diseases, such as atherosclerosis, embolism, hypertension, vasospasm and restenosis after angioplasty. 4 In recent years, the nitric oxide system has been found to be an endogenous anti-atherosclerotic mechanism. High risk factors leading to atherosclerosis include hyperlipidemia, obesity, hypertension, and diabetes. These risk factors can cause vascular endothelial injury, endothelial dysfunction, and decreased nitric oxide synthesis. The integrity of endothelial cells is destroyed, and lipids in the blood are easily infiltrated and infiltrated under the intima of the blood vessels. In addition, mononuclear cells migrate and phagocytose the subendothelial lipids, gradually forming a fatty streak. Nitric oxide synthesis and release are reduced, nitric oxide inhibits platelet and leukocyte adhesion, and platelets and other components form a large number of adherent aggregates to form thrombus, causing vascular stenosis, and even acute occlusion. Nitric oxide inhibits VSMC proliferation. , VSMC hyperplasia and migration, force atherosclerosis. In addition, the N〇/ET secretion balance was lost and the ET content was increased. In addition to its powerful contractile vasculature, ET also promotes the proliferation of VSMC, and it is closely related to the dynamic sclerosing. The following is a description of the specific efficacy and mechanism of action of the hawthorn extract in the compositions provided herein. In the present invention, the hawthorn may be a dry mature fruit of the genus Hawthorn red and the big fruit hawthorn or wild hawthorn of the genus Aphididae. Hawthorn mainly contains behenic acid, citric acid, malic acid, ursolic acid, oleanolic acid, tartaric acid and other organic acids, as well as flavonoids such as quercetin, hyperoside, vitexin, etc. Vitamins and minerals such as vitamin B1, B2 'vitamin C, carotenoids and calcium, phosphorus, iron and other essential trace elements. Hawthorn has a wide range of clinical applications in traditional Chinese medicine. In recent years, its pharmacological effects have been deepened, and the effects of blood pressure, lipid metabolism, protection of cardiovascular and cerebrovascular system, immune promotion, and cancer prevention have been different. Development and utilization. The antihypertensive effect of hawthorn: The depressor mechanism of hawthorn is mainly caused by peripheral vasodilation, and is also related to the effect of sputum or central influence. The total flavonoids of Hawthorn l〇mg/kg can reduce the blood pressure of cats by 40% and maintain 5~lOmin. The total extract of W also has obvious central antihypertensive effect on mice, rabbits and cats. At the same time, experiments have also been carried out to prove that the ethanol extract of hawthorn has the effect of lowering the blood pressure of the cat, and can enhance the central inhibition of sodium pentobarbital to facilitate blood pressure reduction. Calcium-lowering effect of hawthorn: The active ingredients in hawthorn extract can effectively lower serum total cholesterol, triglyceride, low-density lipoprotein, malondialdehyde level, increase ApoA2 -1 level, SOD activity and NK cell viability, and adjust blood lipids Reduce the incidence of atherosclerotic plaque and prevent the occurrence and development of experimental atherosclerosis. The hawthorn in the present invention is rich in active ingredients such as hyperoside and ursolic acid, and hyperoside is the main component of hawthorn flavonoids, and ursolic acid is a main component of hawthorn triterpenoids and has antioxidant activity. And the effect of lowering blood fat, it was observed that both compounds significantly reduced serum TCH and elevated HDL m:H ratio in high-fat mice, indicating that it has the effect of lowering cholesterol and regulating blood lipids. And it has the effect of increasing the activity of SOD in lipemia and mouse serum. This effect can significantly reduce the damage of superoxide radicals to vascular endothelium during hyperlipidemia, and is beneficial to the decomposition and metabolism of lipid peroxide to protect Vascular endothelium. The effect of hawthorn on the cardiovascular system, first of all, hawthorn has the effect of promoting myocardial contraction and protecting the myocardium. The ethanol extract of Daguoshan of Guangxi was applied to the isolated frog myocardium, which showed that it could promote the contraction of frog myocardium. The pharmacological effects of Hawthorn genus 7 200841827, Hawthorn Red, Hawthorn, Yunnan Hawthorn, and Wild Hawthorn were compared. It is believed that all four drugs have anti-myocardial blood loss and protect the myocardium. Experiments have shown that hawthorn can reduce the content of myocardial lipofuscin, promote the activity of superoxide dismutase, inhibit the activity of type B monoamine oxidase, and thus protect the myocardium. For male patients with cardio-cerebral vascular disease, the results showed that the mixture can reduce the activity of plasma xanthine oxidase, add superoxide dismutase _ sex, and resist the damage of superoxide free radicals, thereby protecting the cardiovascular and cerebrovascular diseases of patients. effect. Some foreign reports have shown that taking Hawthorn preparations can increase the ability of patients with chronic heart failure. Hawthorn can increase coronary flow: Hawthorn flavonoids are injected intravenously into dogs at 2-3 mg/kg, coronary flow is significantly increased, myocardial oxygen consumption is not significantly reduced, vascular resistance is reduced, and heart rate is slowed. Intravenous injection of 2g/kg of rabbit or subcutaneous injection of alcohol extract 4g/kg inhibited the heart rate caused by vasopressin. Hawthorn has a strong heart effect. The flavonoids 3',4,5,7-tetrahydroxyflavone-7-glucoside (hit) and rutin (rut) in the hawthorn cause the dose of isolated rabbit femoral artery after contraction of KCI. Dependent vasodilation. Hawthorn has an antioxidant effect, Hawthorn extract can remove free radicals in the body, and the ability to scavenge free radicals has a significant dose-dependent relationship. Hawthorn extract can increase nitric oxide and nitric oxide synthase activity in aortic wall tissue. Nitric oxide is a biosynthesis that inhibits ET by increasing intracellular cGMP content, and has an effect of promoting vascular smooth muscle cell proliferation against ET. The use of hawthorn extract can regulate the NO / ET secretion balance in the body by increasing the synthesis and release of nitric oxide, thereby more effectively protecting the cardiovascular system and preventing atherosclerosis. According to the study, high-fat diet can significantly reduce the level of plasma nitric oxide in rats. After taking the extract of hawthorn for a period of time, the plasma nitric oxide of each group of high-fat rats increased significantly, and was slightly higher than the normal group. But there is no significant difference. It was shown that rats exposed to hawthorn extract can relax blood vessels, inhibit vascular endothelial damage, and normalize nitric oxide by increasing plasma nitric oxide concentration. The following is a description of the specific efficacy and mechanism of action of vitamin E in the compositions provided herein. Vitamin E has a strong antioxidant effect. Vitamin E has an antioxidant effect because it is easily oxidized and can be oxidized instead of other substances, thus protecting other substances from oxidation. • Vitamin E itself has a structure that produces phenolic oxygen. The resulting phenolic oxygen can quench and react with singlet oxygen, protect unsaturated fatty acids from singlet oxygen damage, and be oxidized by anionic and hydroxyl radicals. The unsaturated fatty acid is protected from free radical attack, thereby inhibiting the automatic oxidation of fatty acids. After taking vitamins for coronary heart disease (CHD) patients to observe their antioxidant effects, they found that after taking the low dose (〇.2g/time, once/day) of vitamin Ε under the same time conditions, the patient's plasma OX- The MDA level of LDL serum was significantly lower than that before administration, and the SOD was significantly increased, indicating that vitamin E at this dose had a significant antioxidant effect. The dose of sputum increased to 〇.2g/time, after 2 times/曰, the confrontation The effect of the oxidation index is more pronounced than the low dose group. It indicates that increasing the dose of vitamin E can increase its antioxidant activity. When the human body's blood lipid is too high, the blood low-density lipoprotein (LDL) 7jc is increased, while the LDL-oxidized peroxidized LDL is cytotoxic, and the endothelial cells themselves also produce lipid peroxide, which causes the arterial endothelial cells to undergo peroxidative damage. And cause arteriosclerosis. As mentioned earlier, vitamin E can be oxidized prior to LDL, thereby reducing the production of toxic peroxidized LDL and, therefore, has the effect of preventing elevated blood lipids and reducing blood cholesterol levels. 8 200841827 Vitamin E as a trace element is very important in the antioxidant process. In addition to its antioxidant action with tea polyphenols, vitamin e is also an important supplier of nitric oxide pathways. In the study, it was shown that the degree of lipid peroxidation, the oxidation sensitivity of lipoprotein, and the cGMP content as a marker of nitric oxide activity in mice were measured before and after taking vitamin E. After taking vitamins, the concentration of nitrification triphosphate in the blood plasma of the mice decreased significantly, the degree of lipid peroxidation decreased, the oxidation sensitivity of lipoproteins decreased, and the content of cGMP in the blood increased. It is indicated that vitamin E is likely to be involved in the regulation of lipoproteins as a donor of the nitric oxide pathway. High-density lipoprotein in lipoprotein is often a risk factor for atherosclerotic vascular disease, but its oxidation reduces its binding to cells and accelerates its clearance, which is not conducive to the realization of its corresponding biological functions. . Studies have shown that the use of vitamin E can reduce the oxidative metabolism rate of high-density lipoprotein (HDL2) tenfold, and can prolong its retention time in blood vessels, but not for high-density lipoprotein (HDL3) Effect (Table 1) This indicates that vitamin E can play an antioxidant role against lipoproteins under the nitric oxide pathway. Table 1 shows the effects of monounsaturated fatty acids (MUFA), polyunsaturated fatty acids (PUFA), and vitamin E on the oxidation rate and retention time of different types of lipoproteins. • Table 1 lipoprotein oxidation parameters MUFA FOFA FUFA+EF retention time such as adding LDL 742 i 56J ^ 2*4^ mu# HOL2 45 ^ 12Ja 133 lL6b 115.6 44c HDO 419 : 11,4 26.2 1.4.6 \9J ^ U o耷 耷 U iUhv. mm LOL 12 m 5,2 0J ' 5,5 LO aiis HOL2 36,2 ^ 6Φ1 24.6 * ^ 8 fiber HOL3 L\S TM 2 2 123 - U 0 値 is the average bauxite SE ° The concentration of 0^〇4 used for the determination of oxidation parameters: 1 for 200 fronts, 100//mol/L for HDL2, and 50/zmol/L for HDL3. As shown in Table 1, the numbers in the columns with different superscripts are significantly different. [Embodiment] Scheme 1 (Health care products for cardiovascular system for adolescent males with high blood lipids and other symptoms) Hawthorn extract llOmg

Vitamin E powder 30I.U Arginine 900mg Method: Take arginine, hawthorn extract and vitamin E, dextrin, starch, food flavor (all flavors, preferably hawthorn or orange flavor), aspartame, Stir well, add ethanol, sieve, pelletize, dry, and granulate to obtain the finished product. Method for monthly use: Mix with warm water, gently stir until dissolved and drink, one to two servings per serving. Scheme 2 (Health Products for Cardiovascular System for Adolescent Women with High Blood Lipids) 9 200841827 Hawthorn Extract 90mg

Vitamin E powder 20I.U Arginine 700mg Method: Take arginine, hawthorn extract and vitamin E, dextrin, dinosaur, food flavor (all flavors, preferably hawthorn or orange flavor), aspartame Stir well, add ethanol, sieve, make granules, dry, whole grain, and get the finished product. How to use: Use warm water to make up, $ to stir until dissolved and drink, one or two times a day. Option 3 (Used in the male cardiovascular system) Hawthorn extract 300mg

Vitamin E Powder 60LU Arginine 2000mg

Method: Take arginine, hawthorn extract and vitamin E, dextrin, splash powder, food flavor (all flavors, preferably hawthorn or cinnamon flavor), aspartame, stir evenly, add ethanol, sieve, It is made into granules, dried, and granulated to obtain a finished product. How to use: Mix with warm water, gently stir until dissolved and drink, one or two times a day. Option 4 (Health Products for Protecting the Cardiovascular System of Adult Women) Hawthorn Extract 260mg

Vitamin E powder 60LU arginine 1700mg Method: Take arginine, hawthorn extract and vitamin E, dextrin, starch, food flavor (all flavors, preferably hawthorn or orange flavor), aspartame, stir well , into the mouth, into the ethanol, sieving, granules, drying, whole grain, to get the finished product. How to use: Mix with warm water, gently stir until dissolved and drink, one or two times a day. Program 5 (Health supplement for adjuvant treatment of adult male cardiovascular system) Hawthorn extract 800mg

Vitamin E Powder 120I.U Arginine. 5000mg Method: Take arginine, hawthorn extract and vitamin E, dextrin, persuasion, food flavor (all flavors, preferably hawthorn or orange), Asparta Sweet, stir well, add ethanol, sift, make granules, dry, whole grain, get the finished product. How to use: Mix with warm water, gently stir until dissolved and drink, one or two times a day. Program 6 (Health supplement for adjuvant treatment of cardiovascular system in adult women) Hawthorn extract 600mg

Vitamin E powder 120I.U arginine 4000mg 10 200841827 Method: Take arginine, hawthorn extract and vitamin E, dextrin, splash powder, food flavor (all flavors, preferably hawthorn or orange flavor), Aspen Ba-sweet, stir evenly, add ethanol, sieve, make granules, dry, whole grain, get the finished product. How to use: Mix with warm water, gently stir until dissolved, then use one or two servings a day. Scheme 7 (Strong formula, spare parts for cardiovascular system)

Vitamin E powder 90LU Hawthorn extract lOOOOmg arginine 6000mg Method: take the main drug, dextrin, temple powder, edible strawberry flavor, aspartame. Stir well. Ethanol is added, sieved, granulated, dried, and granulated to obtain a finished product. How to use: Use warm water to make up, $ to stir until dissolved and drink, one or two times a day. BRIEF DESCRIPTION OF THE DRAWINGS Fig. 1 is a flow chart showing the preparation of a health care product for regulating blood pressure and protecting the cardiovascular and cerebrovascular system introduced in the present invention. Figure 2 shows the biological process by which L. arginine is metabolized in vivo to produce nitric oxide and L-citrulline. [Main component symbol description] 1 arginine 2 hawthorn extract

3 Vitamin E 4 «Materials such as dextrin, starch, food flavor, etc. 5 Add ethanol 6 Arrow 7 Make granules 8 Dry 9 Whole grain 10 Get finished product a, L-arginine 11 200841827 b, Calcium and calcium Protein c, tetrahydrofolate d, nicotinamide adenine dinucleotide e, oxygen f, water. g, N-hydroxy-L-arginine h, L-citrulline i, nitric oxide

Claims (1)

200841827 X. Patent application scope: A composition 5 contains arginine and hawthorn extract. 2. The composition according to claim 1, wherein the arginine content is 848-870 mg and the hawthorn extract content is 106-141 mg, based on the total weight of the composition. 3. The composition according to claim 1, comprising vitamin E. 4. The composition according to claim 3, wherein the vitamin E content is 10-24 mg based on the total weight of the composition of 1000 mg. 5. The composition according to claim 1, comprising lecithin. 6. The composition according to claim 2, wherein the arginine content is 850-868 mg and the hawthorn extract content is 112-136 mg, based on the total weight of the composition. The composition according to any one of claims 1 to 6, which is prepared as a solid composition or a liquid dosage form as an active composition by adding a corresponding excipient. 8. The composition of claim 7, wherein the solid dosage form is a tablet, a powder or a capsule. The composition according to any one of claims 1 to 8 as an application for preparing a health care product having blood pressure regulating and protecting cardiovascular and cerebrovascular systems. The application according to the scope of claim 9 wherein the daily intake of arginine is 500-13000 mg, and the daily intake of the extract of hawthorn is 60-1600 mg. 11. According to the application of Patent Application No. 9, wherein the arginine intake of arginine is 4500-6000 mg, and the daily intake of yam extract is 500-700 mg 〇 13