NZ522608A - Material comprising a liquid crystal polymer for packing a nicotine-containing product - Google Patents
Material comprising a liquid crystal polymer for packing a nicotine-containing productInfo
- Publication number
- NZ522608A NZ522608A NZ522608A NZ52260800A NZ522608A NZ 522608 A NZ522608 A NZ 522608A NZ 522608 A NZ522608 A NZ 522608A NZ 52260800 A NZ52260800 A NZ 52260800A NZ 522608 A NZ522608 A NZ 522608A
- Authority
- NZ
- New Zealand
- Prior art keywords
- nicotine
- package
- lcp
- packaging material
- polymer
- Prior art date
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B15/00—Layered products comprising a layer of metal
- B32B15/04—Layered products comprising a layer of metal comprising metal as the main or only constituent of a layer, which is next to another layer of the same or of a different material
- B32B15/08—Layered products comprising a layer of metal comprising metal as the main or only constituent of a layer, which is next to another layer of the same or of a different material of synthetic resin
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B27/00—Layered products comprising a layer of synthetic resin
- B32B27/36—Layered products comprising a layer of synthetic resin comprising polyesters
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B15/00—Layered products comprising a layer of metal
- B32B15/20—Layered products comprising a layer of metal comprising aluminium or copper
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
- C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
- C08G63/065—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids the hydroxy and carboxylic ester groups being bound to aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
- C08G63/12—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from polycarboxylic acids and polyhydroxy compounds
- C08G63/16—Dicarboxylic acids and dihydroxy compounds
- C08G63/18—Dicarboxylic acids and dihydroxy compounds the acids or hydroxy compounds containing carbocyclic rings
- C08G63/181—Acids containing aromatic rings
- C08G63/185—Acids containing aromatic rings containing two or more aromatic rings
- C08G63/187—Acids containing aromatic rings containing two or more aromatic rings containing condensed aromatic rings
- C08G63/189—Acids containing aromatic rings containing two or more aromatic rings containing condensed aromatic rings containing a naphthalene ring
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2311/00—Metals, their alloys or their compounds
- B32B2311/24—Aluminium
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2553/00—Packaging equipment or accessories not otherwise provided for
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/13—Hollow or container type article [e.g., tube, vase, etc.]
- Y10T428/1352—Polymer or resin containing [i.e., natural or synthetic]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/13—Hollow or container type article [e.g., tube, vase, etc.]
- Y10T428/1352—Polymer or resin containing [i.e., natural or synthetic]
- Y10T428/1355—Elemental metal containing [e.g., substrate, foil, film, coating, etc.]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/13—Hollow or container type article [e.g., tube, vase, etc.]
- Y10T428/1352—Polymer or resin containing [i.e., natural or synthetic]
- Y10T428/1379—Contains vapor or gas barrier, polymer derived from vinyl chloride or vinylidene chloride, or polymer containing a vinyl alcohol unit
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/13—Hollow or container type article [e.g., tube, vase, etc.]
- Y10T428/1352—Polymer or resin containing [i.e., natural or synthetic]
- Y10T428/1379—Contains vapor or gas barrier, polymer derived from vinyl chloride or vinylidene chloride, or polymer containing a vinyl alcohol unit
- Y10T428/1383—Vapor or gas barrier, polymer derived from vinyl chloride or vinylidene chloride, or polymer containing a vinyl alcohol unit is sandwiched between layers [continuous layer]
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Laminated Bodies (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Packages (AREA)
- Wrappers (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Polyesters Or Polycarbonates (AREA)
Abstract
A method for packaging a nicotine-containing product comprises placing the product in a package comprising a packaging material. The packaging material comprises a liquid crystal polymer, LCP. The LCP preferably comprises hydroxy benzoic acid and hydroxy naphtenic acid and the packaging material may further comprise one ore more further polymers. The product could comprise a patch for transdermally administrating nicotine, a nicotine containing chewing gum, a nicotine containing tablet, a spray for nasal administration of nicotine or a device for inhaling nicotine.
Description
<div class="application article clearfix" id="description">
<p class="printTableText" lang="en">New Zealand Paient Spedficaiion for Paient Number 522608 <br><br>
NEW ZEALAND PATENTS ACT, 1953 <br><br>
No: Divided out of No. 512522 <br><br>
Date: Dated 12 January 2000 <br><br>
COMPLETE SPECIFICATION <br><br>
METHOD AND USE OF A MATERIAL FOR PACKING A NICOTINE-CONTAINING PRODUCT <br><br>
We, PHARMACIA AB, a Swedish company, of SE-112 87 Stockholm, Sweden, do hereby declare the invention for which we pray that a patent may be granted to us, and the method by which it is to be performed, to be particularly described in and by the following statement: <br><br>
-1 - <br><br>
(followed by page la) <br><br>
intellectual property office of n.z <br><br>
1 2 JUN 2003 <br><br>
received <br><br>
Version 1.2.3 <br><br>
la <br><br>
522608 <br><br>
Technical field <br><br>
The present invention relates to methods and uses of materials for packaging 5 nicotine-containing products. <br><br>
Background art <br><br>
For many years tobacco smoking has been one of the major health problems throughout the world. Smoking is now recognized as the main cause for e.g. high blood pressure and lung cancer. However, because of the addictive nature of nicotine it is ut-10 terly difficult for heavy smokers to completely stop smoking. An acceptable alternative to smoking has been to provide nicotine in a form or manner other than by smoking, e.g. as a chewing gum containing nicotine as an active ingredient, see e.g. US 3,845,217. Other products used as substitutes for smoking are tablets containing nicotine, see e.g. US 5,543,424, devices for allowing nicotine to be inhaled through an elongated tube, see 15 e.g. US 5,501,236, nicotine containing nasal sprays, see e.g. US 5,656,255, patches for administering nicotine transdermally, see e.g. US 4,915,950, etc. <br><br>
The primary requirement when packaging drugs and food is the demand that the package must protect the product against penetration of moisture and oxygen from the environment. Very seldom the product itself constitutes any problems. Nicotine, on the 20 other hand, is very aggressive towards its environment and migrates through most known materials. It is also very hygroscopic and therefore sensitive to moisture and when exposed to oxygen or air the nicotine turns brown. Because of the toxicity of nicotine and because the expected shelf-life for nicotine containing products is as long as up to two years, commonly used materials within the package industry, e.g, polypropylene, 25 polyethylene and polyvinyl chloride therefore cannot be used for nicotine containing products. <br><br>
A known polymer which fulfills the requirements of oxygen, water and nicotine impermeability is commercially available under the trademark Barex* being a copolymer made of acrylonitrile and methylmetacrylate and grafted to nitrile rubber on the main 30 chain. Due to the copolymerization with methylmethacrylate the polymer becomes softer and is possible to process. Bar ex® is available with different amounts of nitrile rubber, is amorphous and is a glass polymer at room temperature. ;intellectual property [i office of n.z ;12 JUN 2003 f. received ;The temperature range within which Barex® may be processed is, however, very narrow rendering the polymer difficult to process resulting in a large amount of discarded material. This is partly due to Bar ex® having a temperature dependent elasticity. Today, Bar ex® is also associated with a high price. ;The use of Barex® in a nicotine impermeable container is disclosed in US 5,501,236. ;Summary of the invention ;The reader's attention is directed to our related New Zealand Patent Specification NZ 512522 (hereinafter NZ 512522) which describes and claims a method of packaging a nicotine containing product using a packaging material comprising dimethyl-2,6-naphthalene dicarboxynate and/or 2,6-naphthalene dicarboxylic acid monomers and use of the material to manufacture a package for keeping nicotine-containing products. ;It is therefore an object of the present invention to provide an alternative to using Barex®, which exhibits favorable characteristics of oxygen, water and nicotine impermeability, but which does not suffer from the above-mentioned drawbacks or at least provides the public with a useful choice. ;Accordingly, one aspect of the present invention provides a method for packaging a nicotine-containing product comprising placing the product in a package comprising a packaging material comprising a liquid crystal polymer, LCP. ;Another aspect provides for use of the packaging material described immediately above for the manufacture of a package for keeping nicotine-containing products. ;The packaging material useful herein comprises a liquid crystal polymer, LCP, and has excellent characteristics of oxygen, water and nicotine impermeability. Due to the temperature ranges the polymers useful herein are favorable to process and will have an acceptable price. The material useful herein is known per se, but its excellent nicotine barrier properties have not been known. Neither has its use for making packages for nicotine-containing products been contemplated. ;Detailed description of the invention ;The packaging material use of the invention and the method of packaging of the invention are intended for use in connection with ;12 JUN 2003 ;RECEIVED ;522608 ;nicotine containing products for therapeutic treatment of patients having an addiction to nicotine. Examples of such products are chewing gums, sublingual tablets, nasal sprays, nicotine patches and nicotine inhaling devices, all marketed through Pharmacia & Upjohn. These products are all classified as drugs and thus, the requirements of product stability are high. The expected shelf life is two years without any noticeable change regarding composition, concentration and dosage. Specific ranges for allowed variations have been established in accordance with requirements from the authorities, e.g. Food and Drug Administration, FDA, in the USA. ;In chewing gums the nicotine is usually present in the form of a complex with an insoluble cation-exchanger, which is disbursed in a gum base, in order to be stabilized. In ;3 ;tablets the nicotine is usually present in the form of an inclusion complex. Only small amounts, if any, of nicotine are in contact with the package for chewing gums and tablets and thus, the demand for a nicotine barrier becomes lower for these products. The pH for a chewing gum is usually slightly above 4. ;5 In nasal spray the nicotine is present in a liquid solution having a concentration of approximately 10 mg/ml and a pH of approximately 7. The nasal spray is distributed in glass flasks inert to the aggressiveness of nicotine. However, the nicotine solution also comes into contact with seals and pumping devices made of polymeric material. ;In a patch and in an inhaling device primarily nicotine vapor comes into contact 10 with the package. Here the concentration depends on the vapor pressure of the nicotine that varies with temperature. In room temperature the concentration in a patch is approximately 250 mg/ml. In a patch and in an inhaling device the pH is approximately 9-10. ;A number of factors are important when materials for nicotine-containing packages 15 are chosen. The nicotine must not migrate through the packaging material and disappear from the system or be accumulated uncontrollably in the packaging material. Also, the nicotine must be protected from oxygen due to the fact that it is easily decomposed in contact with air or oxygen. Products containing nicotine also turns brown or yellow when only small amounts of decomposition products are present resulting in cosmetic 20 drawbacks long before any stability limits have been passed. A good oxygen barrier is therefore of utmost importance. ;Besides the above mentioned primary demands on good nicotine resistance and low oxygen permeability, other important factors to take into consideration regarding packaging materials for nicotine-containing products are water and moisture permeation, 25 processability, price and environmental impact. ;The water barrier is important especially in the nasal spray where loss of water has large impact on the concentration of the product. Water barrier characteristics are also important in other forms of distribution since water may have an impact on permeation characteristics of the polymer. Great consideration should also be taken to the process-30 ability since large-scale industrial production is considered where even small problems may involve large costs. ;With the aim to find a packaging material for the packaging of a nicotine-containing product, which fulfills the above mentioned demands two different types of polymers, were found. ;The first of these materials described herein but used in the invention of ;PEN is polyester based on dimethyl-2,6-naphthalene dicarboxynate or 2,6-naphthalene dicarboxylic acid monomers. Dimethyl-2,6-naphthalene dicarboxynate and -2,6-naphthalene dicarboxylic acid monomers are e.g. sold by Amoco under the trade name NDC and NDA-monomer respectively. PEN is semicrystalline and is a glass polymer at room temperature. ;There are other polymers, such as PTN (polytrimethylene naphthalate) which are based on the same monomers. PTN differs from PEN only in that the ethylene chain has been exchanged to a propylene chain. It is also envisageable to use polymers comprising both dimethyl-2,6-naphthalene dicarboxynate or 2,6-naphthalene dicarboxylic acid monomers. ;PEN differs from PET (polyethylene tereftalate), which is another, more commonly used polyester, in that the benzene ring in the PET molecule has been exchanged for naphtene in PEN. This makes the PEN structure more rigid than the PET structure and the features of PEN more favorable for this invention than the features of PET. ;The second nicotine impermeable polymer of the invention is polyester based Liquid Crystal Polymer, LCP. LCP is useful in the present invention. One example thereof is Vectra® A 530 having the following structure: ;H-- -O ;O ;II ;o- ;(73%)L ;.--OH ;J (27%) ;*2 JUN 2003 <br><br>
LCPs constitute a group of materials, which have a characteristic molecular structure. LCP polymers consist of rigid rod-like macromolecules'that align in the melt to produce a liquid-like structure. This specific structure brings considerable improvement in mechanical properties compared with conventional polymers and a number of other exceptional properties. The monomers are hydroxy benzoic acid and hydroxy naphtenic acid. A typical LCP polymer, such as the above-mentioned Vectra® A 530, is filled with 30 % of mineral filler. The LCP material has a dense structure as a consequence of high crystallinity, is chemically resistant and has extremely low diffusion rates for oxygen and water. <br><br>
It was surprisingly found that in addition to the above mentioned barrier properties against water and oxygen PEN, PTN and LCP also exhibit excellent barrier properties against nicotine. In below Table 1 is shown a comparison of the properties of Barex® 210, PEN 14991 and Vectra® A 530. For comparison is added a polymer, Isoplast 2530 (a polyurethane having better barrier characteristics than other polyurethanes due to its high glass transition temperature), which does not have good nicotine impermeability. <br><br>
Bar ex® is marketed by British Petroleum, PEN by Shell and by Eastman, Vectra® by Ticona and Isoplast by Dow. <br><br>
Table 1 <br><br>
Material Properties <br><br>
Material <br><br>
Barex 210 PEN 14991 Vectra A 530 Isoplast 2530 <br><br>
Opacity Morphology <br><br>
Crystallinity <br><br>
Transparent Transparent Opaque Transparent <br><br>
Amorphous Semi High Amorphous crystalline Crystalline <br><br>
Permeability <br><br>
Oxygen cm3 -mm/ m2- day • atm Water g-mm/m2-day <br><br>
2.0 <br><br>
0,3 <br><br>
0,7 <br><br>
1,5 <br><br>
0,05 <br><br>
0.02 <br><br>
2,4 <br><br>
1,2 <br><br>
5 <br><br>
Material Properties <br><br>
Material <br><br>
Barex 210 <br><br>
PEN 14991 <br><br>
Vectra A 530 <br><br>
Isoplast 2530 <br><br>
Nicotine <br><br>
Excellent <br><br>
Excellent <br><br>
Excellent <br><br>
Not acceptable <br><br>
Resistance <br><br>
Equivalent to Barex <br><br>
Equivalent to Barex <br><br>
Inferior to Barex <br><br>
Processing <br><br>
Extrusion <br><br>
+ <br><br>
+ <br><br>
+ <br><br>
+ <br><br>
Injection Molding <br><br>
+ <br><br>
+ <br><br>
+ <br><br>
+ <br><br>
Vacuum <br><br>
+ <br><br>
+ <br><br>
- <br><br>
Forming <br><br>
Blow Molding <br><br>
+ <br><br>
+ <br><br>
+ <br><br>
Applications <br><br>
Film <br><br>
+ <br><br>
+ <br><br>
+ <br><br>
+ <br><br>
Laminate <br><br>
+ <br><br>
+ <br><br>
+ <br><br>
+ <br><br>
Injection Mould details <br><br>
+ <br><br>
+ <br><br>
+ <br><br>
+ <br><br>
Blow Mould details <br><br>
+ <br><br>
+ <br><br>
+ <br><br>
Blisters <br><br>
+ <br><br>
+ <br><br>
- <br><br>
The nicotine resistance of the captioned polymer materials was investigated with sorption tests as follows. Pieces of the respective materials were placed in glass bottles containing nicotine solution and were stored therein at room temperature for 1, 2 and 5 4 weeks. Subsequently the amounts of nicotine sorbed into the respective polymer materials were extracted from the polymers and analyzed by UV, HPLC and GC. The values for Barex 210 were used as reference levels. <br><br>
As explained above PTN, marketed through Shell, is chemically very similar to PEN. In polymer chemistry it is a commonly accepted principle that close chemical simi-10 larity implies similar physical/chemical properties. Hence the above good results for PEN implies that also PTN has good nicotine barrier properties. <br><br>
The nicotine impermeable polymers PEN and PTN can be used alone in film applications or may be combined with other barrier materials in a laminate to further improve the barrier characteristics of the packaging material. Suitable materials 15 for laminating are metal, especially aluminium, foils and other polymers, e.g. polyacrylo-nitrile (PAN), polyamide (PA), polyvinylidene chloride (PVDC), and fluoropolymers, all of which are good oxygen and water barriers. Other polymer materials also suitable are intellectual property <br><br>
OFFICE OF N.Z <br><br>
12 JUN 2003 Received <br><br></p>
</div>
Claims (13)
1. A method for packaging a nicotine-containing product comprising placing the product in a package comprising a packaging material comprising a liquid crystal polymer,<br><br>
2. A method according to claim 1, wherein the LCP comprises hydroxy benzoic acid and hydroxy naphtenic acid.<br><br>
3. A method according to claim 1 or 2, wherein the packaging material further comprises one or more other polymers.<br><br>
4. A method according to claim 1 or 2, wherein the packaging material further comprises one or more other polymers selected from the group comprising polyacrylonitrile<br><br> (PAN), polyamide (PA), polyvinylidene chloride (PVDC), fluoropolymers, ethylene vinyl alcohol copolymer (EVOH), polyvinyl alcohol (PVA), ionomers, polyethylene (PE), and polypropylene (PP) and polyethylene terephtalate (PET).<br><br>
5. A method according to any one of the preceding claims, wherein the packaging material is laminated with one or more metal and/or polymer foil(s).<br><br>
6. A method according to claim 5, wherein the packaging material is laminated with aluminum foil.<br><br>
7. A method according to any one of the preceding claims, wherein the packaging material totally encloses, partially encloses and/or is used to seal a package for a nicotine containing product.<br><br>
8. A method according to any one of the preceding claims, wherein the package is provided with moulds or equivalent into which is cast a substance that upon solidification in the package receives its final form and shape.<br><br>
9. A method according to claim 8, wherein the package comprises a package in which<br><br> LCP.<br><br> tablets or lozenges are directly cast.<br><br>
10. A method according to any one of claims 1 to 8, wherein the product comprises a patch for transdermally administering nicotine, a nicotine containing chewing gum, a nicotine containing tablet, a spray for nasal administration of nicotine, or a device for inhaling nicotine.<br><br>
11. Use of a packaging material as defined in any one of the preceding claims for the manufacture of a package for keeping nicotine-containing products.<br><br>
12. A method according to claim 1 substantially as herein described with reference to any example thereof.<br><br>
13. A use according to claim 11 substantially as herein described with reference to any example thereof.<br><br> intellectual property office of n.z<br><br> 12 JUN 2003 received<br><br> </p> </div>
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9900215A SE9900215D0 (en) | 1999-01-26 | 1999-01-26 | New use |
NZ512522A NZ512522A (en) | 1999-01-26 | 2000-01-12 | Method and use of a material for packing a nicotine-containing product |
Publications (1)
Publication Number | Publication Date |
---|---|
NZ522608A true NZ522608A (en) | 2003-08-29 |
Family
ID=20414210
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NZ522608A NZ522608A (en) | 1999-01-26 | 2000-01-12 | Material comprising a liquid crystal polymer for packing a nicotine-containing product |
NZ512522A NZ512522A (en) | 1999-01-26 | 2000-01-12 | Method and use of a material for packing a nicotine-containing product |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NZ512522A NZ512522A (en) | 1999-01-26 | 2000-01-12 | Method and use of a material for packing a nicotine-containing product |
Country Status (17)
Country | Link |
---|---|
US (1) | US6790496B1 (en) |
EP (1) | EP1154902B1 (en) |
JP (1) | JP2002535454A (en) |
CN (1) | CN1113747C (en) |
AT (1) | ATE321657T1 (en) |
AU (1) | AU745647B2 (en) |
CA (1) | CA2359246C (en) |
DE (1) | DE60026966T2 (en) |
DK (1) | DK1154902T3 (en) |
ES (1) | ES2259601T3 (en) |
HK (1) | HK1043341B (en) |
NZ (2) | NZ522608A (en) |
PT (1) | PT1154902E (en) |
RU (1) | RU2215656C2 (en) |
SE (1) | SE9900215D0 (en) |
TW (1) | TWI266692B (en) |
WO (1) | WO2000044559A1 (en) |
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US9006175B2 (en) | 1999-06-29 | 2015-04-14 | Mannkind Corporation | Potentiation of glucose elimination |
US20030014947A1 (en) * | 2001-07-19 | 2003-01-23 | Sarojini Deevi | Laminated metal foil packaging material and method of making |
SI1494732T1 (en) | 2002-03-20 | 2008-08-31 | Mannking Corp | Inhalation apparatus |
ATE359075T1 (en) | 2002-12-20 | 2007-05-15 | Niconovum Ab | CHEMICALLY AND PHYSICALLY STABLE PARTICLE MATERIAL CONTAINING NICOTINE AND MICROCRYSTALLINE CELLULOSE |
EP1786784B1 (en) | 2004-08-20 | 2010-10-27 | MannKind Corporation | Catalysis of diketopiperazine synthesis |
KR101306384B1 (en) | 2004-08-23 | 2013-09-09 | 맨카인드 코포레이션 | Diketopiperazine salts, diketomorpholine salts or diketodioxane salts for drug delivery |
US9648907B2 (en) * | 2005-05-31 | 2017-05-16 | Philip Morris Usa Inc. | Virtual reality smoking system |
AU2006290227B2 (en) | 2005-09-14 | 2012-08-02 | Mannkind Corporation | Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents |
US20070149756A1 (en) * | 2005-12-26 | 2007-06-28 | Futura Polyesters Limited | Compositions and methods of manufacturing polytrimethylene naphthalate |
US20070232763A1 (en) * | 2006-01-30 | 2007-10-04 | Futura Polyesters Limited | Naphthalate based polyester resin compositions |
US7913699B2 (en) * | 2006-01-31 | 2011-03-29 | U.S. Smokeless Tobacco Company Llc | Tobacco articles and methods |
US7918231B2 (en) | 2006-01-31 | 2011-04-05 | U.S. Smokeless Tobacco Company Llc | Tobacco articles and methods |
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-
2000
- 2000-01-12 ES ES00902222T patent/ES2259601T3/en not_active Expired - Lifetime
- 2000-01-12 DE DE60026966T patent/DE60026966T2/en not_active Expired - Lifetime
- 2000-01-12 WO PCT/SE2000/000017 patent/WO2000044559A1/en active IP Right Grant
- 2000-01-12 JP JP2000595838A patent/JP2002535454A/en active Pending
- 2000-01-12 US US09/889,772 patent/US6790496B1/en not_active Expired - Lifetime
- 2000-01-12 CA CA2359246A patent/CA2359246C/en not_active Expired - Fee Related
- 2000-01-12 NZ NZ522608A patent/NZ522608A/en not_active IP Right Cessation
- 2000-01-12 CN CN00803156A patent/CN1113747C/en not_active Expired - Fee Related
- 2000-01-12 AU AU23352/00A patent/AU745647B2/en not_active Ceased
- 2000-01-12 RU RU2001123218/04A patent/RU2215656C2/en not_active IP Right Cessation
- 2000-01-12 EP EP00902222A patent/EP1154902B1/en not_active Expired - Lifetime
- 2000-01-12 NZ NZ512522A patent/NZ512522A/en not_active IP Right Cessation
- 2000-01-12 AT AT00902222T patent/ATE321657T1/en not_active IP Right Cessation
- 2000-01-12 DK DK00902222T patent/DK1154902T3/en active
- 2000-01-12 PT PT00902222T patent/PT1154902E/en unknown
- 2000-01-29 TW TW089101576A patent/TWI266692B/en not_active IP Right Cessation
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2002
- 2002-07-02 HK HK02104924.1A patent/HK1043341B/en not_active IP Right Cessation
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CN1337903A (en) | 2002-02-27 |
TWI266692B (en) | 2006-11-21 |
SE9900215D0 (en) | 1999-01-26 |
WO2000044559A1 (en) | 2000-08-03 |
CN1113747C (en) | 2003-07-09 |
EP1154902A1 (en) | 2001-11-21 |
DE60026966T2 (en) | 2006-08-24 |
ATE321657T1 (en) | 2006-04-15 |
PT1154902E (en) | 2006-06-30 |
JP2002535454A (en) | 2002-10-22 |
ES2259601T3 (en) | 2006-10-16 |
DE60026966D1 (en) | 2006-05-18 |
HK1043341B (en) | 2003-10-31 |
HK1043341A1 (en) | 2002-09-13 |
EP1154902B1 (en) | 2006-03-29 |
AU745647B2 (en) | 2002-03-28 |
DK1154902T3 (en) | 2006-07-24 |
US6790496B1 (en) | 2004-09-14 |
CA2359246A1 (en) | 2000-08-03 |
RU2215656C2 (en) | 2003-11-10 |
AU2335200A (en) | 2000-08-18 |
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PSEA | Patent sealed | ||
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RENW | Renewal (renewal fees accepted) | ||
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ASS | Change of ownership |
Owner name: MCNEIL AB, SE Free format text: OLD OWNER(S): PFIZER HEALTH AB |
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EXPY | Patent expired |