NZ500645A - 9-Azabicyclo[3.3.1]non-2-ene and nonane derivatives as cholinergic ligands at nicotinic ACh receptors - Google Patents
9-Azabicyclo[3.3.1]non-2-ene and nonane derivatives as cholinergic ligands at nicotinic ACh receptorsInfo
- Publication number
- NZ500645A NZ500645A NZ500645A NZ50064598A NZ500645A NZ 500645 A NZ500645 A NZ 500645A NZ 500645 A NZ500645 A NZ 500645A NZ 50064598 A NZ50064598 A NZ 50064598A NZ 500645 A NZ500645 A NZ 500645A
- Authority
- NZ
- New Zealand
- Prior art keywords
- azabicyclo
- ene
- methyl
- pyridyl
- disease
- Prior art date
Links
- ODYAYVUDAZHKHK-UHFFFAOYSA-N 9-azabicyclo[3.3.1]non-3-ene Chemical compound C1C=CC2CCCC1N2 ODYAYVUDAZHKHK-UHFFFAOYSA-N 0.000 title claims abstract description 8
- 108010009685 Cholinergic Receptors Proteins 0.000 title claims description 22
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- 230000001713 cholinergic effect Effects 0.000 title description 10
- 239000003446 ligand Substances 0.000 title description 4
- BKIMMITUMNQMOS-UHFFFAOYSA-N nonane Chemical class CCCCCCCCC BKIMMITUMNQMOS-UHFFFAOYSA-N 0.000 title description 4
- -1 thiocycloalkoxy Chemical group 0.000 claims abstract description 89
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- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims abstract description 9
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK62897 | 1997-05-30 | ||
| PCT/DK1998/000224 WO1998054182A1 (en) | 1997-05-30 | 1998-05-29 | 9-AZABICYCLO(3.3.1)NON-2-ENE AND NONANE DERIVATIVES AS CHOLINERGIC LIGANDS AT NICOTINIC ACh RECEPTORS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ500645A true NZ500645A (en) | 2001-06-29 |
Family
ID=8095743
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ500645A NZ500645A (en) | 1997-05-30 | 1998-05-29 | 9-Azabicyclo[3.3.1]non-2-ene and nonane derivatives as cholinergic ligands at nicotinic ACh receptors |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6392045B1 (https=) |
| EP (1) | EP0984966B1 (https=) |
| JP (1) | JP2002502383A (https=) |
| CN (1) | CN1205210C (https=) |
| AT (1) | ATE231861T1 (https=) |
| AU (1) | AU736798B2 (https=) |
| CA (1) | CA2289570C (https=) |
| DE (1) | DE69811070T2 (https=) |
| DK (1) | DK0984966T3 (https=) |
| NZ (1) | NZ500645A (https=) |
| WO (1) | WO1998054182A1 (https=) |
| ZA (1) | ZA984640B (https=) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
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| AU2278700A (en) | 1999-01-28 | 2000-08-18 | Neurosearch A/S | Novel azabicyclo derivatives and their use |
| ES2305373T3 (es) * | 1999-01-29 | 2008-11-01 | Abbott Laboratories | Derivados diazabiciclicos como ligandos del receptor nicotinico de la acetilcolina. |
| US7265115B2 (en) | 1999-01-29 | 2007-09-04 | Abbott Laboratories | Diazabicyclic CNS active agents |
| NZ513575A (en) | 1999-05-04 | 2003-07-25 | Neurosearch As | Heteroaryl diazabicycloalkanes useful for treating or preventing a disease or a disorder responsive to the activity of nAChR modulators |
| US6815438B2 (en) | 1999-12-14 | 2004-11-09 | Neurosearch A/S | Heteroaryl-diazabicycloalkanes |
| MY145722A (en) * | 2000-04-27 | 2012-03-30 | Abbott Lab | Diazabicyclic central nervous system active agents |
| JP2003534344A (ja) | 2000-05-25 | 2003-11-18 | ターガセプト，インコーポレイテッド | ニコチン性コリン受容体リガンドとしてのヘテロアリールジアザビシクロアルカン |
| WO2001091925A1 (en) * | 2000-05-31 | 2001-12-06 | Board Of Control Of Michigan Technological University | Compositions and methods for wood preservation |
| NZ522793A (en) | 2000-07-04 | 2005-02-25 | Neurosearch As | Aryl and heteroaryl diazabicycloalkanes, their preparation and use |
| US6579878B1 (en) | 2000-07-07 | 2003-06-17 | Targacept, Inc. | Pharmaceutical compositions and methods for use |
| US6624167B1 (en) | 2000-08-04 | 2003-09-23 | Targacept, Inc. | Pharmaceutical compositions and methods for use |
| CN100398103C (zh) * | 2000-10-13 | 2008-07-02 | 神经研究公司 | 通过烟碱性受体激动剂和单胺能物质的联合作用治疗情感性精神障碍 |
| DE60203007T2 (de) * | 2001-06-01 | 2005-07-07 | Neurosearch A/S | Heteroaryl-diazabicycloalkanderivaten als cns-modulatoren |
| US7238715B2 (en) | 2002-12-06 | 2007-07-03 | The Feinstein Institute For Medical Research | Treatment of pancreatitis using alpha 7 receptor-binding cholinergic agonists |
| JP4750421B2 (ja) † | 2002-12-06 | 2011-08-17 | ノース ショア−ロング アイランド ジュ−イッシュ リサ−チ インスティチュ−ト | α７受容体結合コリン作動性アゴニストを用いる炎症の阻害 |
| AU2005284908B2 (en) | 2004-09-13 | 2011-12-08 | Morningside Venture Investments Limited | Biosynchronous transdermal drug delivery |
| US7662812B2 (en) | 2005-02-16 | 2010-02-16 | Neurosearch A/S | Diazabicyclic aryl derivatives and their use as chinolinergic ligands at nicotinic acetylcholine receptors |
| US8316104B2 (en) | 2005-11-15 | 2012-11-20 | California Institute Of Technology | Method and apparatus for collaborative system |
| ATE473978T1 (de) * | 2005-12-06 | 2010-07-15 | Neurosearch As | Neue diazabicyclische arylderivate und medizinische verwendung dafür |
| WO2007090888A1 (en) | 2006-02-10 | 2007-08-16 | Neurosearch A/S | 3-heteroaryl- 3,9-diazabicyclo[3.3.1]nonane derivatives as nicotinic acetylcholine receptor agonists |
| CN101379063A (zh) | 2006-02-10 | 2009-03-04 | 神经研究公司 | 3,9-二氮杂双环[3.3.1]壬烷衍生物及其作为单胺神经递质再摄取抑制剂的用途 |
| AU2007213670A1 (en) * | 2006-02-10 | 2007-08-16 | Neurosearch A/S | 3,9-diazabicyclo[3.3.1]nonane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| EP1987032A1 (en) | 2006-02-14 | 2008-11-05 | NeuroSearch A/S | 3, 9-diazabicyclo(3.3.1)non-3-yl-aryl methanone derivatives as nicotinic acetylcholine receptor agonists |
| TW200845977A (en) * | 2007-03-30 | 2008-12-01 | Targacept Inc | Sub-type selective azabicycloalkane derivatives |
| CN103977003A (zh) | 2007-04-02 | 2014-08-13 | 帕金森氏病研究院 | 用于降低治疗的副作用的方法和组合物 |
| WO2009058120A1 (en) * | 2007-11-02 | 2009-05-07 | Sri International | Nicotinic acetylcholine receptor modulators |
| US8697722B2 (en) | 2007-11-02 | 2014-04-15 | Sri International | Nicotinic acetylcholine receptor modulators |
| EP2288609A2 (en) * | 2008-06-10 | 2011-03-02 | NeuroSearch A/S | Indolyl-pyridazinyl-diazabicyclononane derivatives in labelled and unlabelled form and their use in diagnostic methods |
| ES2439767T3 (es) | 2008-08-01 | 2014-01-24 | Purdue Pharma Lp | Compuestos de tetrahidropiridinilo y dihidropirrolilo y uso de los mismos |
| RU2560729C2 (ru) | 2010-01-11 | 2015-08-20 | АСТРАЕА ТЕРАПЕУТИКС, ЭлЭлСи | Модуляторы никотиновых ацетилхолиновых рецепторов |
| AU2016211330A1 (en) | 2015-01-28 | 2017-08-03 | Chrono Therapeutics Inc. | Drug delivery methods and systems |
| CA3049529A1 (en) | 2017-01-06 | 2018-07-12 | Chrono Therapeutics Inc. | Transdermal drug delivery devices and methods |
| US11596779B2 (en) | 2018-05-29 | 2023-03-07 | Morningside Venture Investments Limited | Drug delivery methods and systems |
| US12397141B2 (en) | 2018-11-16 | 2025-08-26 | Morningside Venture Investments Limited | Thermally regulated transdermal drug delivery system |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3133073A (en) * | 1959-12-10 | 1964-05-12 | Sterling Drug Inc | 3-aryl-1, 5-iminocycloalkanes and preparation thereof |
| DE1174793B (de) * | 1962-11-13 | 1964-07-30 | Boehringer & Soehne Gmbh | Verfahren zur Herstellung von 3ª‡-Phenyl-granatanen und ihren Hydrohalogeniden |
| US3509161A (en) * | 1967-07-10 | 1970-04-28 | Boehringer & Soehne Gmbh | 3-phenyl-granatene-(2)-derivatives |
| IL59004A0 (en) | 1978-12-30 | 1980-03-31 | Beecham Group Ltd | Substituted benzamides their preparation and pharmaceutical compositions containing them |
| EP0093488A3 (en) | 1982-03-18 | 1984-05-23 | Beecham Group Plc | Nortropyl benzopyrrolinone compounds, process for their preparation and pharmaceutical compositions containing them |
| ES2153360T3 (es) * | 1991-05-29 | 2001-03-01 | Abbott Lab | Compuestos de isoxazol e de isotiazol que mejoran las funciones de razonamiento. |
| JPH11512443A (ja) * | 1995-09-22 | 1999-10-26 | ノボ ノルディスク アクティーゼルスカブ | 新規な置換アザ環式またはアザ二環式化合物 |
| CA2271749A1 (en) * | 1996-11-26 | 1998-06-18 | Christopher Richard Ayles Godfrey | 8-azabicyclo¬3.2.1|octane-, 8-azabicyclo¬3.2.1|oct-6-ene-, 9-azabicyclo¬3.3.1|nonane-, 9-aza-3-oxabicyclo¬3.3.1|nonane- and 9-aza-3-thiabicyclo¬3.3.1|nonane derivatives, their preparation and their use as insecticides |
-
1998
- 1998-05-29 WO PCT/DK1998/000224 patent/WO1998054182A1/en not_active Ceased
- 1998-05-29 DE DE69811070T patent/DE69811070T2/de not_active Expired - Lifetime
- 1998-05-29 NZ NZ500645A patent/NZ500645A/en unknown
- 1998-05-29 DK DK98921377T patent/DK0984966T3/da active
- 1998-05-29 AT AT98921377T patent/ATE231861T1/de not_active IP Right Cessation
- 1998-05-29 CN CNB988054159A patent/CN1205210C/zh not_active Expired - Fee Related
- 1998-05-29 EP EP98921377A patent/EP0984966B1/en not_active Expired - Lifetime
- 1998-05-29 JP JP50012999A patent/JP2002502383A/ja not_active Withdrawn
- 1998-05-29 ZA ZA984640A patent/ZA984640B/xx unknown
- 1998-05-29 CA CA002289570A patent/CA2289570C/en not_active Expired - Fee Related
- 1998-05-29 AU AU74260/98A patent/AU736798B2/en not_active Ceased
-
1999
- 1999-11-29 US US09/450,635 patent/US6392045B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ZA984640B (en) | 1998-12-11 |
| AU7426098A (en) | 1998-12-30 |
| CN1205210C (zh) | 2005-06-08 |
| DE69811070D1 (de) | 2003-03-06 |
| CA2289570C (en) | 2007-04-03 |
| DE69811070T2 (de) | 2003-10-02 |
| ATE231861T1 (de) | 2003-02-15 |
| CN1257500A (zh) | 2000-06-21 |
| AU736798B2 (en) | 2001-08-02 |
| EP0984966B1 (en) | 2003-01-29 |
| JP2002502383A (ja) | 2002-01-22 |
| CA2289570A1 (en) | 1998-12-03 |
| WO1998054182A1 (en) | 1998-12-03 |
| DK0984966T3 (da) | 2003-05-05 |
| EP0984966A1 (en) | 2000-03-15 |
| US6392045B1 (en) | 2002-05-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PSEA | Patent sealed | ||
| RENW | Renewal (renewal fees accepted) | ||
| RENW | Renewal (renewal fees accepted) |