NZ241308A

NZ241308A - Detergent composition containing cellulase

Detergent composition containing cellulase

Info

Publication number: NZ241308A
Authority: NZ; New Zealand
Prior art keywords: ala; detergent composition; ser; lys; pro
Prior art date: 1991-01-16

Application number

NZ24130892A

Other languages

English (en)

Inventor

Andre Cesar Baeck

Alfred Busch

Raphael Angeline A Ceulemans

Original Assignee

Procter & Gamble

Priority date

1991-01-16

Filing date

1992-01-15

Publication date

1994-07-26

1991-01-16 Priority claimed from EP91870006.3A external-priority patent/EP0495344A1/en

1991-11-06 Priority claimed from EP91202879A external-priority patent/EP0495257B1/en

1992-01-15 Application filed by Procter & Gamble filed Critical Procter & Gamble

1994-07-26 Publication of NZ241308A publication Critical patent/NZ241308A/en

Links

108010059892 Cellulase Proteins 0.000 title claims description 166
239000000203 mixture Substances 0.000 title claims description 126
239000003599 detergent Substances 0.000 title claims description 103
229940106157 cellulase Drugs 0.000 title claims description 88
238000000034 method Methods 0.000 claims description 61
230000000694 effects Effects 0.000 claims description 40
229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 34
-1 alkaline-earth metal salts Chemical class 0.000 claims description 33
239000004744 fabric Substances 0.000 claims description 33
239000001768 carboxy methyl cellulose Substances 0.000 claims description 31
235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 31
239000008112 carboxymethyl-cellulose Substances 0.000 claims description 31
238000005406 washing Methods 0.000 claims description 28
102000004190 Enzymes Human genes 0.000 claims description 24
108090000790 Enzymes Proteins 0.000 claims description 24
229940088598 enzyme Drugs 0.000 claims description 20
230000002285 radioactive effect Effects 0.000 claims description 20
150000003839 salts Chemical class 0.000 claims description 20
239000000243 solution Substances 0.000 claims description 20
210000004027 cell Anatomy 0.000 claims description 17
239000004094 surface-active agent Substances 0.000 claims description 17
108020004414 DNA Proteins 0.000 claims description 15
108091028043 Nucleic acid sequence Proteins 0.000 claims description 15
229910000323 aluminium silicate Inorganic materials 0.000 claims description 14
239000012085 test solution Substances 0.000 claims description 13
230000008569 process Effects 0.000 claims description 12
239000013598 vector Substances 0.000 claims description 12
150000001875 compounds Chemical class 0.000 claims description 11
239000011256 inorganic filler Substances 0.000 claims description 10
229910003475 inorganic filler Inorganic materials 0.000 claims description 10
241001480714 Humicola insolens Species 0.000 claims description 8
239000002243 precursor Substances 0.000 claims description 8
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical class [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 7
241000894007 species Species 0.000 claims description 7
108010071097 threonyl-lysyl-proline Proteins 0.000 claims description 7
108020004511 Recombinant DNA Proteins 0.000 claims description 6
229910021653 sulphate ion Inorganic materials 0.000 claims description 6
241000228212 Aspergillus Species 0.000 claims description 5
230000001747 exhibiting effect Effects 0.000 claims description 5
UHPMCKVQTMMPCG-UHFFFAOYSA-N 5,8-dihydroxy-2-methoxy-6-methyl-7-(2-oxopropyl)naphthalene-1,4-dione Chemical compound CC1=C(CC(C)=O)C(O)=C2C(=O)C(OC)=CC(=O)C2=C1O UHPMCKVQTMMPCG-UHFFFAOYSA-N 0.000 claims description 4
DZLQXIFVQFTFJY-BYPYZUCNSA-N Cys-Gly-Gly Chemical compound SC[C@H](N)C(=O)NCC(=O)NCC(O)=O DZLQXIFVQFTFJY-BYPYZUCNSA-N 0.000 claims description 4
241000223218 Fusarium Species 0.000 claims description 4
ZAUHSLVPDLNTRZ-QXEWZRGKSA-N Pro-Val-Asn Chemical compound [H]N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(N)=O)C(O)=O ZAUHSLVPDLNTRZ-QXEWZRGKSA-N 0.000 claims description 4
229910052784 alkaline earth metal Inorganic materials 0.000 claims description 4
150000001860 citric acid derivatives Chemical class 0.000 claims description 4
108010053725 prolylvaline Proteins 0.000 claims description 4
VCSABYLVNWQYQE-UHFFFAOYSA-N Ala-Lys-Lys Natural products NCCCCC(NC(=O)C(N)C)C(=O)NC(CCCCN)C(O)=O VCSABYLVNWQYQE-UHFFFAOYSA-N 0.000 claims description 3
SMEYEQDCCBHTEF-FXQIFTODSA-N Cys-Pro-Ala Chemical compound [H]N[C@@H](CS)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(O)=O SMEYEQDCCBHTEF-FXQIFTODSA-N 0.000 claims description 3
BOJYMMBYBNOOGG-DCAQKATOSA-N Lys-Pro-Ala Chemical compound [H]N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(O)=O BOJYMMBYBNOOGG-DCAQKATOSA-N 0.000 claims description 3
MKGIILKDUGDRRO-FXQIFTODSA-N Pro-Ser-Ser Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1 MKGIILKDUGDRRO-FXQIFTODSA-N 0.000 claims description 3
WFAUDCSNCWJJAA-KXNHARMFSA-N Thr-Lys-Pro Chemical compound C[C@@H](O)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@@H]1C(O)=O WFAUDCSNCWJJAA-KXNHARMFSA-N 0.000 claims description 3
239000001963 growth medium Substances 0.000 claims description 3
OEVCHROQUIVQFZ-YTLHQDLWSA-N Ala-Thr-Ala Chemical compound C[C@H](N)C(=O)N[C@@H]([C@H](O)C)C(=O)N[C@@H](C)C(O)=O OEVCHROQUIVQFZ-YTLHQDLWSA-N 0.000 claims description 2
ZXKNLCPUNZPFGY-LEWSCRJBSA-N Ala-Tyr-Pro Chemical compound C[C@@H](C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N2CCC[C@@H]2C(=O)O)N ZXKNLCPUNZPFGY-LEWSCRJBSA-N 0.000 claims description 2
NZWDWXSWUQCNMG-GARJFASQSA-N Asp-Lys-Pro Chemical compound C1C[C@@H](N(C1)C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)O)N)C(=O)O NZWDWXSWUQCNMG-GARJFASQSA-N 0.000 claims description 2
241000228245 Aspergillus niger Species 0.000 claims description 2
241000193830 Bacillus <bacterium> Species 0.000 claims description 2
241000894006 Bacteria Species 0.000 claims description 2
241000588724 Escherichia coli Species 0.000 claims description 2
XHVONGZZVUUORG-WEDXCCLWSA-N Gly-Thr-Lys Chemical compound NCC(=O)N[C@@H]([C@H](O)C)C(=O)N[C@H](C(O)=O)CCCCN XHVONGZZVUUORG-WEDXCCLWSA-N 0.000 claims description 2
241000223198 Humicola Species 0.000 claims description 2
241000880493 Leptailurus serval Species 0.000 claims description 2
UWKNTTJNVSYXPC-CIUDSAMLSA-N Lys-Ala-Ser Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CCCCN UWKNTTJNVSYXPC-CIUDSAMLSA-N 0.000 claims description 2
OPTCSTACHGNULU-DCAQKATOSA-N Lys-Cys-Val Chemical compound CC(C)[C@@H](C(O)=O)NC(=O)[C@H](CS)NC(=O)[C@@H](N)CCCCN OPTCSTACHGNULU-DCAQKATOSA-N 0.000 claims description 2
LUTDBHBIHHREDC-IHRRRGAJSA-N Lys-Pro-Lys Chemical compound NCCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(O)=O LUTDBHBIHHREDC-IHRRRGAJSA-N 0.000 claims description 2
DIBZLYZXTSVGLN-CIUDSAMLSA-N Lys-Ser-Ser Chemical compound [H]N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(O)=O DIBZLYZXTSVGLN-CIUDSAMLSA-N 0.000 claims description 2
GIKFNMZSGYAPEJ-HJGDQZAQSA-N Lys-Thr-Asp Chemical compound [H]N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(O)=O GIKFNMZSGYAPEJ-HJGDQZAQSA-N 0.000 claims description 2
YKBSXQFZWFXFIB-VOAKCMCISA-N Lys-Thr-Lys Chemical compound NCCCC[C@H](N)C(=O)N[C@@H]([C@H](O)C)C(=O)N[C@@H](CCCCN)C(O)=O YKBSXQFZWFXFIB-VOAKCMCISA-N 0.000 claims description 2
CAVRAQIDHUPECU-UVOCVTCTSA-N Lys-Thr-Thr Chemical compound [H]N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O CAVRAQIDHUPECU-UVOCVTCTSA-N 0.000 claims description 2
OHXUUQDOBQKSNB-AVGNSLFASA-N Lys-Val-Arg Chemical compound NCCCC[C@H](N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(O)=O OHXUUQDOBQKSNB-AVGNSLFASA-N 0.000 claims description 2
ZUGXSSFMTXKHJS-ZLUOBGJFSA-N Ser-Ala-Ala Chemical compound [H]N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(O)=O ZUGXSSFMTXKHJS-ZLUOBGJFSA-N 0.000 claims description 2
WTUJZHKANPDPIN-CIUDSAMLSA-N Ser-Ala-Lys Chemical compound C[C@@H](C(=O)N[C@@H](CCCCN)C(=O)O)NC(=O)[C@H](CO)N WTUJZHKANPDPIN-CIUDSAMLSA-N 0.000 claims description 2
FPCGZYMRFFIYIH-CIUDSAMLSA-N Ser-Lys-Ser Chemical compound [H]N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(O)=O FPCGZYMRFFIYIH-CIUDSAMLSA-N 0.000 claims description 2
DJDSEDOKJTZBAR-ZDLURKLDSA-N Thr-Gly-Ser Chemical compound C[C@@H](O)[C@H](N)C(=O)NCC(=O)N[C@@H](CO)C(O)=O DJDSEDOKJTZBAR-ZDLURKLDSA-N 0.000 claims description 2
COYSIHFOCOMGCF-UHFFFAOYSA-N Val-Arg-Gly Natural products CC(C)C(N)C(=O)NC(C(=O)NCC(O)=O)CCCN=C(N)N COYSIHFOCOMGCF-UHFFFAOYSA-N 0.000 claims description 2
239000003513 alkali Substances 0.000 claims description 2
108010069926 arginyl-glycyl-serine Proteins 0.000 claims description 2
230000006870 function Effects 0.000 claims description 2
108010003700 lysyl aspartic acid Proteins 0.000 claims description 2
108010073969 valyllysine Proteins 0.000 claims description 2
210000005253 yeast cell Anatomy 0.000 claims description 2
150000001413 amino acids Chemical group 0.000 claims 2
LSLIRHLIUDVNBN-CIUDSAMLSA-N Ala-Asp-Lys Chemical compound C[C@H](N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(O)=O)CCCCN LSLIRHLIUDVNBN-CIUDSAMLSA-N 0.000 claims 1
DECCMEWNXSNSDO-ZLUOBGJFSA-N Ala-Cys-Ala Chemical compound C[C@H](N)C(=O)N[C@@H](CS)C(=O)N[C@@H](C)C(O)=O DECCMEWNXSNSDO-ZLUOBGJFSA-N 0.000 claims 1
SAHQGRZIQVEJPF-JXUBOQSCSA-N Ala-Thr-Lys Chemical compound C[C@H](N)C(=O)N[C@@H]([C@H](O)C)C(=O)N[C@H](C(O)=O)CCCCN SAHQGRZIQVEJPF-JXUBOQSCSA-N 0.000 claims 1
WVNFNPGXYADPPO-BQBZGAKWSA-N Arg-Gly-Ser Chemical compound NC(N)=NCCC[C@H](N)C(=O)NCC(=O)N[C@@H](CO)C(O)=O WVNFNPGXYADPPO-BQBZGAKWSA-N 0.000 claims 1
IIFDPDVJAHQFSR-WHFBIAKZSA-N Asn-Glu Chemical compound NC(=O)C[C@H](N)C(=O)N[C@H](C(O)=O)CCC(O)=O IIFDPDVJAHQFSR-WHFBIAKZSA-N 0.000 claims 1
WMLFFCRUSPNENW-ZLUOBGJFSA-N Asp-Ser-Ala Chemical compound [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(O)=O WMLFFCRUSPNENW-ZLUOBGJFSA-N 0.000 claims 1
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical class [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims 1
QQAYIVHVRFJICE-AEJSXWLSSA-N Cys-Val-Pro Chemical compound CC(C)[C@@H](C(=O)N1CCC[C@@H]1C(=O)O)NC(=O)[C@H](CS)N QQAYIVHVRFJICE-AEJSXWLSSA-N 0.000 claims 1
241000233866 Fungi Species 0.000 claims 1
241000835535 Gliocephalotrichum humicola Species 0.000 claims 1
JVWPPCWUDRJGAE-YUMQZZPRSA-N Gly-Asn-Leu Chemical compound [H]NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(O)=O JVWPPCWUDRJGAE-YUMQZZPRSA-N 0.000 claims 1
241000235648 Pichia Species 0.000 claims 1
LGSANCBHSMDFDY-GARJFASQSA-N Pro-Glu-Pro Chemical compound C1C[C@H](NC1)C(=O)N[C@@H](CCC(=O)O)C(=O)N2CCC[C@@H]2C(=O)O LGSANCBHSMDFDY-GARJFASQSA-N 0.000 claims 1
FHJQROWZEJFZPO-SRVKXCTJSA-N Pro-Val-Val Chemical compound CC(C)[C@@H](C(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H]1CCCN1 FHJQROWZEJFZPO-SRVKXCTJSA-N 0.000 claims 1
AGDDLOQMXUQPDY-BZSNNMDCSA-N Tyr-Tyr-Ser Chemical compound [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CO)C(O)=O AGDDLOQMXUQPDY-BZSNNMDCSA-N 0.000 claims 1
SLLKXDSRVAOREO-KZVJFYERSA-N Val-Ala-Thr Chemical compound C[C@H]([C@@H](C(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](C(C)C)N)O SLLKXDSRVAOREO-KZVJFYERSA-N 0.000 claims 1
XBJKAZATRJBDCU-GUBZILKMSA-N Val-Pro-Ala Chemical compound CC(C)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(O)=O XBJKAZATRJBDCU-GUBZILKMSA-N 0.000 claims 1
108010087924 alanylproline Proteins 0.000 claims 1
108010070783 alanyltyrosine Proteins 0.000 claims 1
150000004649 carbonic acid derivatives Chemical class 0.000 claims 1
125000002467 phosphate group Chemical class [H]OP(=O)(O[H])O[*] 0.000 claims 1
239000000463 material Substances 0.000 description 35
229940105329 carboxymethylcellulose Drugs 0.000 description 30
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 25
229910001868 water Inorganic materials 0.000 description 25
HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 description 24
108090000623 proteins and genes Proteins 0.000 description 22
102000004169 proteins and genes Human genes 0.000 description 21
238000012360 testing method Methods 0.000 description 18
238000002360 preparation method Methods 0.000 description 15
229920001577 copolymer Polymers 0.000 description 14
VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 14
229920001296 polysiloxane Polymers 0.000 description 13
108010084185 Cellulases Proteins 0.000 description 12
102000005575 Cellulases Human genes 0.000 description 12
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 12
238000005342 ion exchange Methods 0.000 description 12
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 11
229910021536 Zeolite Inorganic materials 0.000 description 11
238000012216 screening Methods 0.000 description 11
239000010457 zeolite Substances 0.000 description 11
239000004927 clay Substances 0.000 description 10
229920005646 polycarboxylate Polymers 0.000 description 10
239000003795 chemical substances by application Substances 0.000 description 9
239000004615 ingredient Substances 0.000 description 9
229920000742 Cotton Polymers 0.000 description 8
XKUKSGPZAADMRA-UHFFFAOYSA-N glycyl-glycyl-glycine Natural products NCC(=O)NCC(=O)NCC(O)=O XKUKSGPZAADMRA-UHFFFAOYSA-N 0.000 description 8
BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 description 7
239000002253 acid Substances 0.000 description 7
125000003275 alpha amino acid group Chemical group 0.000 description 7
239000007844 bleaching agent Substances 0.000 description 7
239000002609 medium Substances 0.000 description 7
239000011734 sodium Substances 0.000 description 7
239000000758 substrate Substances 0.000 description 7
QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 6
IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 6
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
125000000217 alkyl group Chemical group 0.000 description 6
230000002209 hydrophobic effect Effects 0.000 description 6
239000000523 sample Substances 0.000 description 6
159000000000 sodium salts Chemical class 0.000 description 6
239000002689 soil Substances 0.000 description 6
244000060011 Cocos nucifera Species 0.000 description 5
235000013162 Cocos nucifera Nutrition 0.000 description 5
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 5
108091005804 Peptidases Proteins 0.000 description 5
239000004365 Protease Substances 0.000 description 5
125000004432 carbon atom Chemical group C* 0.000 description 5
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 5
238000004140 cleaning Methods 0.000 description 5
235000014113 dietary fatty acids Nutrition 0.000 description 5
239000000194 fatty acid Substances 0.000 description 5
229930195729 fatty acid Natural products 0.000 description 5
239000008103 glucose Substances 0.000 description 5
239000007788 liquid Substances 0.000 description 5
244000005700 microbiome Species 0.000 description 5
239000002736 nonionic surfactant Substances 0.000 description 5
239000002245 particle Substances 0.000 description 5
229920000642 polymer Polymers 0.000 description 5
108010020755 prolyl-glycyl-glycine Proteins 0.000 description 5
239000000377 silicon dioxide Substances 0.000 description 5
239000007921 spray Substances 0.000 description 5
XSLGWYYNOSUMRM-ZKWXMUAHSA-N Ala-Val-Asn Chemical compound [H]N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(N)=O)C(O)=O XSLGWYYNOSUMRM-ZKWXMUAHSA-N 0.000 description 4
BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical group [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 4
OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 4
AHZNUGRZHMZGFL-GUBZILKMSA-N Met-Arg-Ser Chemical compound CSCC[C@H](N)C(=O)N[C@H](C(=O)N[C@@H](CO)C(O)=O)CCCNC(N)=N AHZNUGRZHMZGFL-GUBZILKMSA-N 0.000 description 4
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102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 4
XTZNCVSCVHTPAI-UHFFFAOYSA-N Salmeterol xinafoate Chemical compound C1=CC=CC2=C(O)C(C(=O)O)=CC=C21.C1=C(O)C(CO)=CC(C(O)CNCCCCCCOCCCCC=2C=CC=CC=2)=C1 XTZNCVSCVHTPAI-UHFFFAOYSA-N 0.000 description 4
SVWQEIRZHHNBIO-WHFBIAKZSA-N Ser-Gly-Cys Chemical compound [H]N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CS)C(O)=O SVWQEIRZHHNBIO-WHFBIAKZSA-N 0.000 description 4
239000004902 Softening Agent Substances 0.000 description 4
BGRWYDHXPHLNKA-UHFFFAOYSA-N Tetraacetylethylenediamine Chemical compound CC(=O)N(C(C)=O)CCN(C(C)=O)C(C)=O BGRWYDHXPHLNKA-UHFFFAOYSA-N 0.000 description 4
RVMNUBQWPVOUKH-HEIBUPTGSA-N Thr-Ser-Thr Chemical compound [H]N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(O)=O RVMNUBQWPVOUKH-HEIBUPTGSA-N 0.000 description 4
239000012190 activator Substances 0.000 description 4
108010024078 alanyl-glycyl-serine Proteins 0.000 description 4
125000000539 amino acid group Chemical group 0.000 description 4
150000007942 carboxylates Chemical class 0.000 description 4
229920002678 cellulose Polymers 0.000 description 4
239000001913 cellulose Substances 0.000 description 4
239000002299 complementary DNA Substances 0.000 description 4
230000001276 controlling effect Effects 0.000 description 4
108010004073 cysteinylcysteine Proteins 0.000 description 4
108010069495 cysteinyltyrosine Proteins 0.000 description 4
LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 4
239000011159 matrix material Substances 0.000 description 4
238000005259 measurement Methods 0.000 description 4
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 4
239000002773 nucleotide Substances 0.000 description 4
125000003729 nucleotide group Chemical group 0.000 description 4
108010024654 phenylalanyl-prolyl-alanine Proteins 0.000 description 4
229920001223 polyethylene glycol Polymers 0.000 description 4
238000010561 standard procedure Methods 0.000 description 4
238000006467 substitution reaction Methods 0.000 description 4
108010017949 tyrosyl-glycyl-glycine Proteins 0.000 description 4
MNZHHDPWDWQJCQ-YUMQZZPRSA-N Ala-Leu-Gly Chemical compound C[C@H](N)C(=O)N[C@@H](CC(C)C)C(=O)NCC(O)=O MNZHHDPWDWQJCQ-YUMQZZPRSA-N 0.000 description 3
108010065511 Amylases Proteins 0.000 description 3
102000013142 Amylases Human genes 0.000 description 3
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