NO993225L - farnesyl transferase - Google Patents
farnesyl transferaseInfo
- Publication number
- NO993225L NO993225L NO993225A NO993225A NO993225L NO 993225 L NO993225 L NO 993225L NO 993225 A NO993225 A NO 993225A NO 993225 A NO993225 A NO 993225A NO 993225 L NO993225 L NO 993225L
- Authority
- NO
- Norway
- Prior art keywords
- alkyl
- hydrogen
- optionally substituted
- residue
- compounds
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/72—4,7-Endo-alkylene-iso-indoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Abstract
Forbindelser med den generelle formel (I), der Ar betyr en substituert eller kondensert fenylrest eller en aromatisk, polycyklisk eller heterocyklisk rest, R betyr en rest med den generelle formel -(CH2)m-X,-(CH2)n-Z er X, er en enkeltbinding, O, S; m = O, 1; n = O, l, 2; restene CH2 kan være substituert; Z betyr karboksy, COOR* (R«= alkyl), CON(R7)(R8) (R7 = hydrogen eller alkyl og R, = hydrogen, hydroicsy, arylsulfonyl, heterocykel, eventuelt substituert amino, eventuelt substituert alkyloksy, eventuelt substituert alkyl, amino), PO(OR9)2 (R9 = hydrogen eller alkyl), en rest -NH-CO-T (T = hydrogen eller eventuelt substituert alkyl), eller også en rest - CH,¿1-/\ m R, og R2 er hydrogen eller halogen eller alkyl, eventuelt substituert alkyloksy, alkyltio, alkyloksykarbonyl eller også Ri og R2 i orto til hver- andre danner en heterocykel inneholdende l eller 2, eventuelt substituerte heteroatomer, R3 og RA er hydrogen eller halogen eller alkyl, alkenyl, alkyloksy, alkyltio, karboksy eller alkyloksykarbonyl, R5 er hydrogen, alkyl eller alkyltio, X er O eller S eller -NU-, -CO-, metylen, vinyldiyl, alken-l,l-diyl eller cykloalkan-l.l-diyl og Y er O eller S, i racemisk form samt i optiske isomerer og saltene av forbindelsene med den generelle formel (I). Forbindelsene med formel (I) har interessante farmasøytiske egenskaper og viser seg å være inhibitorer av farnesyltransferase med bemerkelsesverdige anti-tumorale og anti-leukemiske egenskaper. Forbindelsene finner særlig anvendelse for fremstilling av medikamenter for inhibering av farnesyltransferase.Compounds of general formula (I) wherein Ar represents a substituted or condensed phenyl residue or an aromatic, polycyclic or heterocyclic residue, R represents a residue of the general formula - (CH 2) m X, - (CH 2) n Z is X, is a single bond, O, S; m = 0.1; n = 0.1, 2; the residues CH2 may be substituted; Z means carboxy, COOR * (R + = alkyl), CON (R7) (R8) (R7 = hydrogen or alkyl and R, = hydrogen, hydroxy, arylsulfonyl, heterocycle, optionally substituted amino, optionally substituted alkyloxy, optionally substituted alkyl, amino), PO (OR9) 2 (R9 = hydrogen or alkyl), a residue -NH-CO-T (T = hydrogen or optionally substituted alkyl), or also a residue - CH, ¿1 - / m R, and R2 is hydrogen or halogen or alkyl, optionally substituted alkyloxy, alkylthio, alkyloxycarbonyl or also R1 and R2 in ortho to each other form a heterocycle containing 1 or 2, optionally substituted heteroatoms, R3 and RA are hydrogen or halogen or alkyl, alkenyl, alkyloxy, alkylthio, carboxy or alkyloxycarbonyl, R5 is hydrogen, alkyl or alkylthio, X is O or S or -NU-, -CO-, methylene, vinyldiyl, alkene-1, 1-diyl or cycloalkan-11-diyl and Y is O or S, in racemic form as well as in optical isomers and the salts of the compounds of general formula (I). The compounds of formula (I) have interesting pharmaceutical properties and are found to be inhibitors of farnesyl transferase with remarkable anti-tumor and anti-leukemic properties. The compounds find particular use for the preparation of drugs for inhibiting farnesyl transferase.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9616206A FR2757855B1 (en) | 1996-12-30 | 1996-12-30 | NOVEL FARNESYL TRANSFERASE INHIBITORS, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
| PCT/FR1997/002407 WO1998029390A1 (en) | 1996-12-30 | 1997-12-23 | Farnesyl transferase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO993225D0 NO993225D0 (en) | 1999-06-29 |
| NO993225L true NO993225L (en) | 1999-08-24 |
Family
ID=9499293
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO993225A NO993225L (en) | 1996-12-30 | 1999-06-29 | farnesyl transferase |
Country Status (32)
| Country | Link |
|---|---|
| EP (1) | EP0948483B1 (en) |
| JP (1) | JP2001509147A (en) |
| KR (1) | KR20000062391A (en) |
| AR (1) | AR008950A1 (en) |
| AT (1) | ATE214367T1 (en) |
| AU (1) | AU741921B2 (en) |
| BR (1) | BR9714498A (en) |
| CA (1) | CA2275943A1 (en) |
| CO (1) | CO4920252A1 (en) |
| CZ (1) | CZ233599A3 (en) |
| DE (1) | DE69711081T2 (en) |
| DK (1) | DK0948483T3 (en) |
| DZ (1) | DZ2389A1 (en) |
| EA (1) | EA002114B1 (en) |
| ES (1) | ES2172033T3 (en) |
| FR (1) | FR2757855B1 (en) |
| HU (1) | HUP0001747A3 (en) |
| ID (1) | ID22922A (en) |
| IL (1) | IL130453A0 (en) |
| MA (1) | MA26460A1 (en) |
| NO (1) | NO993225L (en) |
| NZ (1) | NZ336042A (en) |
| PE (1) | PE28199A1 (en) |
| PL (1) | PL334345A1 (en) |
| PT (1) | PT948483E (en) |
| SK (1) | SK88399A3 (en) |
| TN (1) | TNSN97214A1 (en) |
| TR (1) | TR199901502T2 (en) |
| UY (1) | UY24832A1 (en) |
| WO (1) | WO1998029390A1 (en) |
| YU (1) | YU30299A (en) |
| ZA (1) | ZA9711734B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2787327B1 (en) * | 1998-12-21 | 2003-01-17 | Aventis Pharma Sa | COMPOSITIONS CONTAINING FARNESYL TRANSFERASE INHIBITORS |
| FR2796640A1 (en) * | 1999-07-22 | 2001-01-26 | Aventis Pharma Sa | New 3,9-ethano-2,3,3a,4,9,9a-hexahydro-1H-benzo (f) isoindole derivatives, are farnesyl transferase inhibitors useful for treating hyperproliferative disorders, e.g. psoriasis, restenosis or especially cancer |
| FR2796641B1 (en) * | 1999-07-22 | 2001-09-21 | Aventis Pharma Sa | NOVEL PROCESS FOR THE PREPARATION OF BENZOPERHYDROISOINDOLE COMPOUNDS |
| FR2845994B1 (en) * | 2002-10-18 | 2006-05-19 | Servier Lab | NOVEL SUBSTITUTED BENZO [E] [1,4] OXAZINO [3,2-G] ISOINDOLE DERIVATIVES, PROCESS FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME |
| WO2005089504A2 (en) * | 2004-03-18 | 2005-09-29 | The Brigham And Women's Hospital, Inc. | Methods for the treatment of synucleinopathies |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUT75308A (en) * | 1993-11-05 | 1997-05-28 | Warner Lambert Co | Substituted di- and tripeptide inhibitors of protein:farnesyl transferase |
| FR2736641B1 (en) * | 1995-07-10 | 1997-08-22 | Rhone Poulenc Rorer Sa | NOVEL FARNESYL TRANSFERASE INHIBITORS, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
-
1996
- 1996-12-30 FR FR9616206A patent/FR2757855B1/en not_active Expired - Fee Related
-
1997
- 1997-12-03 PE PE1997001089A patent/PE28199A1/en not_active Application Discontinuation
- 1997-12-23 EA EA199900608A patent/EA002114B1/en not_active IP Right Cessation
- 1997-12-23 IL IL13045397A patent/IL130453A0/en unknown
- 1997-12-23 CZ CZ992335A patent/CZ233599A3/en unknown
- 1997-12-23 CA CA002275943A patent/CA2275943A1/en not_active Abandoned
- 1997-12-23 JP JP52968698A patent/JP2001509147A/en not_active Ceased
- 1997-12-23 YU YU30299A patent/YU30299A/en unknown
- 1997-12-23 SK SK883-99A patent/SK88399A3/en unknown
- 1997-12-23 NZ NZ336042A patent/NZ336042A/en unknown
- 1997-12-23 ID IDW990618A patent/ID22922A/id unknown
- 1997-12-23 DE DE69711081T patent/DE69711081T2/en not_active Expired - Fee Related
- 1997-12-23 WO PCT/FR1997/002407 patent/WO1998029390A1/en not_active Application Discontinuation
- 1997-12-23 BR BR9714498A patent/BR9714498A/en not_active IP Right Cessation
- 1997-12-23 DK DK97953000T patent/DK0948483T3/en active
- 1997-12-23 EP EP97953000A patent/EP0948483B1/en not_active Expired - Lifetime
- 1997-12-23 PL PL97334345A patent/PL334345A1/en unknown
- 1997-12-23 HU HU0001747A patent/HUP0001747A3/en unknown
- 1997-12-23 AT AT97953000T patent/ATE214367T1/en not_active IP Right Cessation
- 1997-12-23 ES ES97953000T patent/ES2172033T3/en not_active Expired - Lifetime
- 1997-12-23 TR TR1999/01502T patent/TR199901502T2/en unknown
- 1997-12-23 AU AU56694/98A patent/AU741921B2/en not_active Ceased
- 1997-12-23 KR KR1019997005966A patent/KR20000062391A/en not_active Application Discontinuation
- 1997-12-23 PT PT97953000T patent/PT948483E/en unknown
- 1997-12-26 MA MA24915A patent/MA26460A1/en unknown
- 1997-12-26 TN TNTNSN97214A patent/TNSN97214A1/en unknown
- 1997-12-27 DZ DZ970239A patent/DZ2389A1/en active
- 1997-12-29 CO CO97075391A patent/CO4920252A1/en unknown
- 1997-12-30 ZA ZA9711734A patent/ZA9711734B/en unknown
- 1997-12-30 AR ARP970106263A patent/AR008950A1/en unknown
- 1997-12-30 UY UY24832A patent/UY24832A1/en not_active Application Discontinuation
-
1999
- 1999-06-29 NO NO993225A patent/NO993225L/en not_active Application Discontinuation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |