FI954105A - New 4-aminopyridines, process for their preparation and compounds containing them - Google Patents

New 4-aminopyridines, process for their preparation and compounds containing them Download PDF

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Publication number
FI954105A
FI954105A FI954105A FI954105A FI954105A FI 954105 A FI954105 A FI 954105A FI 954105 A FI954105 A FI 954105A FI 954105 A FI954105 A FI 954105A FI 954105 A FI954105 A FI 954105A
Authority
FI
Finland
Prior art keywords
stands
atom
compounds
hydrogen
halogen
Prior art date
Application number
FI954105A
Other languages
Finnish (fi)
Swedish (sv)
Other versions
FI954105A0 (en
Inventor
Der Saal Wolfgang Von
Reinhard Heck
Herbert Leinert
Thomas Poll
Karlheinz Stegmeier
Helmut Michel
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE4306506A external-priority patent/DE4306506A1/en
Priority claimed from DE19934312966 external-priority patent/DE4312966A1/en
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Publication of FI954105A publication Critical patent/FI954105A/en
Publication of FI954105A0 publication Critical patent/FI954105A0/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

New 4-aminopyridines have general formula (I), in which R<1> stands for the groups R<6>-SO-NR<7>, R<6>-SO2-NR<7>, R<6>-NR<7>-SO-, R<6>-NR<7>-SO2-, R<6>-SO-O-, R<6>-SO2-O-, R<6>-O-SO- or R<6>-O-SO2; R<2> stands for a hydrogen or halogen atom, a cyano, alkyl, alkoxy or halogen alkyl group; X stands for an oxygen atom, a sulphur atom or the NH group; R<3> and R<4> are the same or different and stand for hydrogen atoms or alkyl groups; R<5> stands for a hydrogen atom, an alkyl group or the aralkyl group; R<6> stands for an aliphatic or cyclic, if required substituted residue; R<7> stands for a hydrogen atom or an aliphatic or cyclic, if required substituted residue; Y stands for a linear or branched alkylene chain; R<8> and R<9> are the same or different and stand for hydrogen atoms, aralkyl, cycloalkyl or alkyl groups which may be substituted once or several times by halogen, hydroxy, alkoxy, alkylcarbonyloxy, amine or carboxy, or R<8> and R<9> form together with the N atom to which they are bound a saturated ring which may contain an additional oxygen, sulphur or nitrogen atom. Also disclosed are the hydrates, solvates and physiologically acceptable salts of these compounds, their optically active forms, racemates and diastereomer mixtures, a process for preparing said compounds, medicaments containing said compounds and the use of said compounds for producing medicaments.
FI954105A 1993-03-03 1995-09-01 Novel 4-aminopyridines, their method of preparation and drugs containing these compounds FI954105A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE4306506A DE4306506A1 (en) 1993-03-03 1993-03-03 Novel 4-alkylaminopyridines - processes for their preparation and medicaments containing these compounds
DE19934312966 DE4312966A1 (en) 1993-04-21 1993-04-21 Novel 4-aminopyridines - process for their preparation and medicaments containing these compounds
PCT/EP1994/000608 WO1994020467A1 (en) 1993-03-03 1994-03-02 New 4-aminopyridines, process for preparing the same and medicaments containing the same

Publications (2)

Publication Number Publication Date
FI954105A true FI954105A (en) 1995-09-01
FI954105A0 FI954105A0 (en) 1995-09-01

Family

ID=25923593

Family Applications (1)

Application Number Title Priority Date Filing Date
FI954105A FI954105A0 (en) 1993-03-03 1995-09-01 Novel 4-aminopyridines, their method of preparation and drugs containing these compounds

Country Status (22)

Country Link
EP (1) EP0687253B1 (en)
JP (1) JPH08507503A (en)
KR (1) KR100252551B1 (en)
CN (1) CN1046710C (en)
AT (1) ATE174590T1 (en)
AU (1) AU682026B2 (en)
CA (1) CA2156729A1 (en)
CZ (1) CZ225495A3 (en)
DE (1) DE59407494D1 (en)
DK (1) DK0687253T3 (en)
ES (1) ES2127919T3 (en)
FI (1) FI954105A0 (en)
GR (1) GR3029691T3 (en)
HU (1) HUT72898A (en)
IL (1) IL108786A (en)
NO (1) NO953447D0 (en)
NZ (1) NZ262725A (en)
PL (1) PL176455B1 (en)
RU (1) RU2126388C1 (en)
SK (1) SK108295A3 (en)
TW (1) TW257757B (en)
WO (1) WO1994020467A1 (en)

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DE4430755A1 (en) * 1994-08-30 1996-03-07 Boehringer Mannheim Gmbh New phosphine oxides, processes for their preparation and medicaments containing these compounds
IL115420A0 (en) 1994-09-26 1995-12-31 Zeneca Ltd Aminoheterocyclic derivatives
US5792769A (en) * 1995-09-29 1998-08-11 3-Dimensional Pharmaceuticals, Inc. Guanidino protease inhibitors
GB9525620D0 (en) 1995-12-15 1996-02-14 Glaxo Group Ltd Chemical compounds
IL124883A0 (en) * 1995-12-29 1999-01-26 Dimensional Pharm Inc Amidino protease inhibitors and pharmaceutical compositions containing the same
GB9602166D0 (en) 1996-02-02 1996-04-03 Zeneca Ltd Aminoheterocyclic derivatives
US6313127B1 (en) 1996-02-02 2001-11-06 Zeneca Limited Heterocyclic compounds useful as pharmaceutical agents
SE9602646D0 (en) * 1996-07-04 1996-07-04 Astra Ab Pharmaceutically useful compounds
CZ45699A3 (en) * 1996-08-14 1999-05-12 Zeneca Limited Substituted pyrimidine derivatives, process of their preparation and pharmaceutical composition containing thereof
WO1998010763A1 (en) * 1996-09-13 1998-03-19 Merck & Co., Inc. Thrombin inhibitors
GB9821483D0 (en) 1998-10-03 1998-11-25 Glaxo Group Ltd Chemical compounds
UA56197C2 (en) 1996-11-08 2003-05-15 Зенека Лімітед Heterocyclic derivatives
TW499412B (en) 1996-11-26 2002-08-21 Dimensional Pharm Inc Aminoguanidines and alkoxyguanidines as protease inhibitors
WO1998024760A1 (en) * 1996-12-03 1998-06-11 Graybill Todd L Aminobenzenedicarboxylic acid-based combinatorial libraries
US6440972B1 (en) 1997-02-13 2002-08-27 Zeneca Limited Heterocyclic compounds useful as oxido-squalene cyclase inhibitors
DE69815509T2 (en) 1997-02-13 2004-05-13 Astrazeneca Ab HETEROCYCLIC COMPOUNDS THAT APPLY AS OXIDO-SQUALEN-CYCLASE INHIBITORS
GB9715895D0 (en) 1997-07-29 1997-10-01 Zeneca Ltd Heterocyclic compounds
JP4327915B2 (en) * 1998-03-30 2009-09-09 株式会社デ・ウエスタン・セラピテクス研究所 Sulfonamide derivatives
CA2345577A1 (en) 1998-10-06 2000-04-13 Mari Itoh 2,3-disubstituted pyridine derivatives, process for the preparation thereof, drug compositions containing the same and intermediates for the preparation
GB9902989D0 (en) 1999-02-11 1999-03-31 Zeneca Ltd Heterocyclic derivatives
AR023510A1 (en) 1999-04-21 2002-09-04 Astrazeneca Ab A TEAM OF PARTS, PHARMACEUTICAL FORMULATION AND USE OF A THROMBIN INHIBITOR.
WO2002012207A1 (en) 2000-08-04 2002-02-14 3-Dimensional Pharmaceuticals, Inc. Cyclic oxyguanidine protease inhibitors
US20050043536A1 (en) * 2001-05-07 2005-02-24 Dashyant Dhanak Sulfonamides
WO2002089785A1 (en) * 2001-05-07 2002-11-14 Smithkline Beecham Corporation Sulfonamides
CN1678314A (en) * 2002-08-27 2005-10-05 默克专利有限公司 Glycinamide derivatives as raf-kinase inhibitors
WO2004026823A1 (en) 2002-09-20 2004-04-01 Pfizer Products Inc. Amide and sulfonamide ligands for the estrogen receptor
KR100847976B1 (en) 2003-11-05 2008-07-22 에프. 호프만-라 로슈 아게 Phenyl derivatives as ppar agonists
WO2008104994A2 (en) * 2007-02-28 2008-09-04 Advinus Therapeutics Private Limited 2,2,2-tri-substituted acetamide derivatives as glucokinase activators, their process and pharmaceutical application
RU2354647C2 (en) * 2007-06-28 2009-05-10 Общество С Ограниченной Ответственностью "Бионика" New compounds with thrombin inhibiting function, and based pharmaceutical compositions
RU2353619C2 (en) * 2007-06-28 2009-04-27 Общество С Ограниченной Ответственностью "Бионика" Novel compounds possessing anticoagulant function, based on them pharmaceutical compositions for treatment of thrombotic conditions and plasma-substituting solution for correction of hypercoagulation disorders in hemodilution
GB0815781D0 (en) 2008-08-29 2008-10-08 Xention Ltd Novel potassium channel blockers
GB0815784D0 (en) 2008-08-29 2008-10-08 Xention Ltd Novel potassium channel blockers
GB0815782D0 (en) 2008-08-29 2008-10-08 Xention Ltd Novel potassium channel blockers
US8265575B2 (en) * 2009-06-16 2012-09-11 Mediatek Inc. Methods for handling a transmitting process and communication apparatuses utilizing the same
US8207639B2 (en) 2009-10-23 2012-06-26 Sunonwealth Electric Machine Industry Co., Ltd. Motor and heating dissipating fan including motor having an annular balancing member
RU2685261C1 (en) * 2018-04-05 2019-04-17 Общество с ограниченной ответственностью "ФК ЛАБОРАТОРИЗ" 4-amino-1-{2-[3-methyl-5-(benzenesulfonyloxy]phenoxy]ethyl}-pyridium chloride substance, having the biologically active agent properties, influencing the mammals blood coagulability naturally running processes, anticoagulant on its basis and its obtaining method by chemical synthesis
CN109172573B (en) * 2018-09-12 2021-01-26 黑龙江中桂制药有限公司 Oral antithrombotic drug and application thereof
CN110669337B (en) * 2019-07-08 2020-09-25 中国科学院长春应用化学研究所 Aromatic diamine monomer and preparation method thereof

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EP0610432A1 (en) * 1991-10-31 1994-08-17 Smithkline Beecham Corporation C8-cyclic peptidomimetics as fibrinogen antagonists
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Also Published As

Publication number Publication date
DK0687253T3 (en) 1999-08-23
TW257757B (en) 1995-09-21
CN1119858A (en) 1996-04-03
KR100252551B1 (en) 2000-05-01
CA2156729A1 (en) 1994-09-15
NO953447L (en) 1995-09-01
JPH08507503A (en) 1996-08-13
AU6257494A (en) 1994-09-26
HUT72898A (en) 1996-06-28
KR960701019A (en) 1996-02-24
NZ262725A (en) 1997-05-26
EP0687253A1 (en) 1995-12-20
PL310520A1 (en) 1995-12-27
IL108786A (en) 1999-04-11
ES2127919T3 (en) 1999-05-01
EP0687253B1 (en) 1998-12-16
SK108295A3 (en) 1996-06-05
HU9502568D0 (en) 1995-11-28
GR3029691T3 (en) 1999-06-30
PL176455B1 (en) 1999-05-31
CN1046710C (en) 1999-11-24
FI954105A0 (en) 1995-09-01
IL108786A0 (en) 1994-06-24
DE59407494D1 (en) 1999-01-28
NO953447D0 (en) 1995-09-01
CZ225495A3 (en) 1996-01-17
AU682026B2 (en) 1997-09-18
ATE174590T1 (en) 1999-01-15
RU2126388C1 (en) 1999-02-20
WO1994020467A1 (en) 1994-09-15

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Owner name: ROCHE DIAGNOSTICS GMBH