NO992225L - Process for the preparation of salts and esters of clavulanic acid - Google Patents

Process for the preparation of salts and esters of clavulanic acid

Info

Publication number
NO992225L
NO992225L NO992225A NO992225A NO992225L NO 992225 L NO992225 L NO 992225L NO 992225 A NO992225 A NO 992225A NO 992225 A NO992225 A NO 992225A NO 992225 L NO992225 L NO 992225L
Authority
NO
Norway
Prior art keywords
esters
preparation
clavulanic acid
salts
pharmaceutically acceptable
Prior art date
Application number
NO992225A
Other languages
Norwegian (no)
Other versions
NO992225D0 (en
Inventor
Johannes Booij
Antonius Van Den Heuvel
Original Assignee
Gist Brocades Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gist Brocades Bv filed Critical Gist Brocades Bv
Publication of NO992225D0 publication Critical patent/NO992225D0/en
Publication of NO992225L publication Critical patent/NO992225L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

En forbedret fremgangsmåte for fremstillingen av farmasøytisk akseptable alkalimetallsalter eller estere av klavulansyre er blitt tilveiebrakt. Videre er det også blitt tilveiebrakt kaliumklavulanat med et ekstremt lavt amininnhold og farmasøytiske sammensetninger som inneholder det samme.An improved process for the preparation of pharmaceutically acceptable alkali metal salts or esters of clavulanic acid has been provided. Furthermore, potassium clavulanate with an extremely low amine content and pharmaceutical compositions containing the same has also been provided.

NO992225A 1996-11-11 1999-05-07 Process for the preparation of salts and esters of clavulanic acid NO992225L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP96203117 1996-11-11
PCT/EP1997/006263 WO1998021212A1 (en) 1996-11-11 1997-11-10 Process for the preparation of salts and esters of clavulanic acid

Publications (2)

Publication Number Publication Date
NO992225D0 NO992225D0 (en) 1999-05-07
NO992225L true NO992225L (en) 1999-05-07

Family

ID=8224563

Family Applications (1)

Application Number Title Priority Date Filing Date
NO992225A NO992225L (en) 1996-11-11 1999-05-07 Process for the preparation of salts and esters of clavulanic acid

Country Status (11)

Country Link
EP (1) EP0937084A1 (en)
JP (1) JP2001503763A (en)
CN (1) CN1238776A (en)
AU (1) AU5551698A (en)
BR (1) BR9713339A (en)
CA (1) CA2271847A1 (en)
NO (1) NO992225L (en)
PL (1) PL333247A1 (en)
TR (1) TR199901631T2 (en)
WO (1) WO1998021212A1 (en)
ZA (1) ZA9710141B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT400033B (en) 1992-03-10 1995-09-25 Biochemie Gmbh NEW METHOD FOR ISOLATING AND PURIFYING CLAVULANIC ACID AND FOR PRODUCING PHARMACOLOGICALLY COMPATIBLE SALTS THEREOF
SI9500134B (en) * 1995-04-20 2004-04-30 Lek, Preparation procedure of pure alkali salts of clavulanic acid
AT403375B (en) * 1995-11-15 1998-01-26 Biochemie Gmbh METHOD FOR FILLING ALKALINE SALTS OF CLAVULANIC ACID
CN1312814A (en) * 1998-07-16 2001-09-12 Dsm公司 Improved process for preparing salts and esters of clavulanic acid
CN1209099C (en) 1999-04-01 2005-07-06 Dsm公司 Agglomerates by crystallisation
EP1284978B2 (en) 2000-05-13 2008-09-10 Smithkline Beecham Plc Process for the purification of a salt of clavulanic acid
US20100055749A1 (en) * 2006-12-01 2010-03-04 Van Der Does Thomas Process for the production of clavulanic acid

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI9300296B (en) * 1992-06-11 1998-06-30 Smithkline Beecham P.L.C. Process and intermediates for the preparation of clavulanic acid
KR100200239B1 (en) * 1992-10-21 1999-06-15 김충환 Process for preparing salts of clavulanic acid
GB9305565D0 (en) * 1993-03-18 1993-05-05 Smithkline Beecham Plc Novel compounds and processes
SI9400107A (en) * 1994-03-02 1995-10-31 Lek Tovarna Farmacevtskih New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804.
GB9426261D0 (en) * 1994-12-24 1995-02-22 Spurcourt Ltd Clavulanic acid salts
SI9500074A (en) * 1995-03-10 1996-10-31 Lek Tovarna Farmacevtskih Process for preparation of alkani salts of clavulanic acid.
SI9500134B (en) * 1995-04-20 2004-04-30 Lek, Preparation procedure of pure alkali salts of clavulanic acid
KR100200242B1 (en) * 1995-05-16 1999-06-15 김충환 Process for preparing clavulanic acid salt

Also Published As

Publication number Publication date
BR9713339A (en) 2000-05-09
WO1998021212A1 (en) 1998-05-22
NO992225D0 (en) 1999-05-07
EP0937084A1 (en) 1999-08-25
PL333247A1 (en) 1999-11-22
AU5551698A (en) 1998-06-03
TR199901631T2 (en) 1999-09-21
JP2001503763A (en) 2001-03-21
ZA9710141B (en) 1998-06-25
CA2271847A1 (en) 1998-05-22
CN1238776A (en) 1999-12-15

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Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application