NO990497L - Modified oligosaccharides - Google Patents

Modified oligosaccharides

Info

Publication number
NO990497L
NO990497L NO990497A NO990497A NO990497L NO 990497 L NO990497 L NO 990497L NO 990497 A NO990497 A NO 990497A NO 990497 A NO990497 A NO 990497A NO 990497 L NO990497 L NO 990497L
Authority
NO
Norway
Prior art keywords
modified oligosaccharides
natural
oligosaccharides
modified
sialyl
Prior art date
Application number
NO990497A
Other languages
Norwegian (no)
Other versions
NO990497D0 (en
Inventor
Gebhard Thoma
Rolf Bonteli
Willy Kinzy
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of NO990497D0 publication Critical patent/NO990497D0/en
Publication of NO990497L publication Critical patent/NO990497L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
    • C07H5/06—Aminosugars
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7008—Compounds having an amino group directly attached to a carbon atom of the saccharide radical, e.g. D-galactosamine, ranimustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Derivater av sialyl-Lewis X og A, hvor den naturlige neuraminsyreresten og den naturlige N-acetylglukosaminmonomeren er byttet ut.Derivatives of sialyl-Lewis X and A, in which the natural neuramic acid residue and the natural N-acetylglucosamine monomer are replaced.

NO990497A 1996-08-08 1999-02-03 Modified oligosaccharides NO990497L (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP96810527 1996-08-08
EP96810526 1996-08-08
EP96810636 1996-09-26
PCT/EP1997/004279 WO1998006730A1 (en) 1996-08-08 1997-08-06 Modified oligosaccharides

Publications (2)

Publication Number Publication Date
NO990497D0 NO990497D0 (en) 1999-02-03
NO990497L true NO990497L (en) 1999-03-24

Family

ID=27237868

Family Applications (1)

Application Number Title Priority Date Filing Date
NO990497A NO990497L (en) 1996-08-08 1999-02-03 Modified oligosaccharides

Country Status (19)

Country Link
EP (1) EP0920437A1 (en)
JP (1) JP2000516224A (en)
KR (1) KR20000029862A (en)
CN (1) CN1227563A (en)
AR (1) AR008283A1 (en)
AU (1) AU720381B2 (en)
BR (1) BR9711117A (en)
CA (1) CA2260854A1 (en)
CO (1) CO4900075A1 (en)
CZ (1) CZ39099A3 (en)
ID (1) ID18010A (en)
IL (1) IL127908A0 (en)
NO (1) NO990497L (en)
NZ (1) NZ334048A (en)
PE (1) PE99298A1 (en)
PL (1) PL331286A1 (en)
SK (1) SK15699A3 (en)
TR (1) TR199900245T2 (en)
WO (1) WO1998006730A1 (en)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5888984A (en) * 1994-05-12 1999-03-30 Dermal Research Laboratories, Inc. Pharmaceutical composition of complex carbohydrates and essential oils and methods of using the same
CA2361268C (en) 1999-02-01 2014-06-10 Dermal Research Laboratories, Inc. A pharmaceutical composition of complex carbohydrates and essential oils and methods of using the same
US7879824B2 (en) 2001-07-31 2011-02-01 Dermal Research Laboratories, Inc. Methods of preventing or treating diseases and conditions using complex carbohydrates
WO2004004636A2 (en) * 2002-07-03 2004-01-15 Glycomimetics, Inc. Compositions and methods for diagnosis and therapy of medical conditions involving angiogenesis
EP1549658B1 (en) 2002-10-11 2009-09-30 Astellas Pharma Europe B.V. Glucose-based compounds with affinity to p-selectin
EP1685145A2 (en) * 2003-11-19 2006-08-02 GlycoMimetics, Inc. Glycomimetic antagonists for both e- and p-selectins
WO2006127906A1 (en) * 2005-05-25 2006-11-30 Glycomimetics, Inc. Heterobifunctional compounds for selectin inhibition
LT2264043T (en) 2005-09-02 2017-12-11 Glycomimetics, Inc. Heterobifunctional pan-selectin inhibitors
NZ598863A (en) * 2007-02-09 2013-11-29 Glycomimetics Inc Methods of use of glycomimetics with replacements for hexoses and n-acetyl hexosamines
WO2009073911A1 (en) 2007-12-10 2009-06-18 Mater Medical Research Institute Treatment and prophylaxis
WO2009126556A1 (en) 2008-04-08 2009-10-15 Glycomimetics, Inc. Pan-selectin inhibitor with enhanced pharmacokinetic activity
US8921328B2 (en) 2010-09-14 2014-12-30 Glycomimetics, Inc. E-selectin antagonists
AU2012358150B2 (en) 2011-12-22 2017-07-20 Glycomimetics, Inc. E-selectin antagonist compounds, compositions, and methods of use
CN104837492B (en) 2012-12-07 2018-04-27 糖模拟物有限公司 Use compound, composition and the method for E-Selectin antagonist mobilizing hematopoietic cell
EP3227310B1 (en) 2014-12-03 2019-07-31 GlycoMimetics, Inc. Heterobifunctional inhibitors of e-selectins and cxcr4 chemokine receptors
US11045485B2 (en) 2016-01-22 2021-06-29 Glycomimetics, Inc. Glycomimetic inhibitors of PA-IL and PA-IIL lectins
US11291678B2 (en) 2016-03-02 2022-04-05 Glycomimetics, Inc Methods for the treatment and/or prevention of cardiovascular disease by inhibition of E-selectin
JP2019524791A (en) 2016-08-08 2019-09-05 グリコミメティクス， インコーポレイテッド Combinations of T cell checkpoint inhibitors with inhibitors of E-selectin or inhibitors of CXCR4 or with heterobifunctional inhibitors of both E-selectin and CXCR4
US11072625B2 (en) 2016-10-07 2021-07-27 Glycomimetics, Inc. Highly potent multimeric e-selectin antagonists
EP3596096A1 (en) 2017-03-15 2020-01-22 GlycoMimetics, Inc. Galactopyranosyl-cyclohexyl derivatives as e-selectin antagonists
EP3717013A1 (en) 2017-11-30 2020-10-07 GlycoMimetics, Inc. Methods of mobilizing marrow infiltrating lymphocytes and uses thereof
EP3732186A1 (en) 2017-12-29 2020-11-04 GlycoMimetics, Inc. Heterobifunctional inhibitors of e-selectin and galectin-3
CN108299525B (en) * 2018-01-05 2021-03-26 佛山科学技术学院 Method for synthesizing Lewis oligose-X
EP3761994A1 (en) 2018-03-05 2021-01-13 GlycoMimetics, Inc. Methods for treating acute myeloid leukemia and related conditions
WO2020139962A1 (en) 2018-12-27 2020-07-02 Glycomimetics, Inc. Heterobifunctional inhibitors of e-selectin and galectin-3
CN109762032A (en) * 2019-01-16 2019-05-17 天津科技大学 A kind of sulfonated lewis X trisaccharide and its synthetic method and application

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993023031A1 (en) * 1992-05-08 1993-11-25 The Biomembrane Institute Multivalent mimetics and peptide mimetics for blocking carbohydrate-dependent cellular interaction and for eliciting anticarbohydrate t-cell response
CA2157489A1 (en) * 1993-03-04 1994-09-15 Masaaki Numata Lewis-associated compound, process for producing the same, and anti-inflammatory
CA2162478A1 (en) * 1993-05-14 1994-11-24 Shawn A. Defrees Sialyl lex analogues as inhibitors of cellular adhesion
MX9704893A (en) * 1994-12-28 1997-10-31 Sumitomo Pharma Lewis x derivative and process for producing the same.

Also Published As

Publication number Publication date
EP0920437A1 (en) 1999-06-09
KR20000029862A (en) 2000-05-25
CZ39099A3 (en) 1999-05-12
CN1227563A (en) 1999-09-01
PE99298A1 (en) 1999-01-21
IL127908A0 (en) 1999-11-30
TR199900245T2 (en) 1999-05-21
JP2000516224A (en) 2000-12-05
NO990497D0 (en) 1999-02-03
CA2260854A1 (en) 1998-02-19
ID18010A (en) 1998-02-19
SK15699A3 (en) 1999-07-12
CO4900075A1 (en) 2000-03-27
NZ334048A (en) 2000-05-26
AU4378897A (en) 1998-03-06
AU720381B2 (en) 2000-06-01
WO1998006730A1 (en) 1998-02-19
AR008283A1 (en) 1999-12-29
PL331286A1 (en) 1999-07-05
BR9711117A (en) 1999-09-08

Similar Documents

Publication Publication Date Title
NO990497L (en) Modified oligosaccharides
DE69106714D1 (en) Hypoglykämische hydroxyharnstoffderivate.
AU5062299A (en) Formulations of anionic polysaccharides
PL336580A1 (en) Fine-molecular compounds useful in treating inflammatory diseases
AU660282B2 (en) Water insoluble derivatives of hyaluronic acid
TW325547B (en) Modular bus with single or double parallel termination
AU1444697A (en) Sialyl-lewisa and sialyl-lewisx epitope analogues
NZ332345A (en) Thermostable xylanases isolated from Microtetraspora
MX9709146A (en) Novel dolastatin derivatives, their preparation and use.
DE69534759D1 (en) Polyanionic polysaccharides and hydrophobic bioabsorbable polymer-containing compositions
MY120511A (en) New pesticides
NO931297D0 (en) ALGINATE OLIGOSACCHARIDE AND PROCEDURE FOR PRODUCING THE SAME
IT9022341A0 (en) EXTRACTS FROM ANIMAL TISSUES, USEFUL IN THERAPY AND DIAGNOSTICS.
MX9703372A (en) Optically clear polymer compositions containing an interpenetrant.
EP0858262A4 (en) Thrombin inhibitors
TR200001745T2 (en) Ketone peroxide derivatives, their preparation and use
BR9813465A (en) Modified polysaccharides that exhibit altered biological recognition
EP0820278A4 (en) Non-immunogenic, biocompatible macromolecular membrane compositions, and methods for making and using same
IL126425A0 (en) Carbohydrate derivatives and their solid-phase synthesis
BR9106554A (en) PROCESS OF INCREASING THE EFFECT OF A POLYSACARIDE HYDROLASE, ENZYMATIC PROCESS USING A POLYSACARIDE HIDROLASE, PREPARATION OF POLYSACARIDE HIDROLASE, PREPARATION OF BENDING-GLUCANASE, PREPARATION OF PULULANASE, MULTIPLE PREPARATION, PULSE PREPARATION
EP1143917A3 (en) Anticonvulsant derivatives useful in treating post traumatic stress disorder
MX9603087A (en) Process to obtain substituted aminocarbonyltriazolinones.
DK1032580T3 (en) Process for N-desmethylation of erythromycins and derivatives thereof
MX9804068A (en) New quinoxalindione derivatives, their preparation and use in medicaments.
FR2720751B1 (en) Polyolefinic graft copolymer.

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application