NO986087L - Oral preparation comprising an antifungal triazole compound - Google Patents
Oral preparation comprising an antifungal triazole compoundInfo
- Publication number
- NO986087L NO986087L NO986087A NO986087A NO986087L NO 986087 L NO986087 L NO 986087L NO 986087 A NO986087 A NO 986087A NO 986087 A NO986087 A NO 986087A NO 986087 L NO986087 L NO 986087L
- Authority
- NO
- Norway
- Prior art keywords
- beads
- oral preparation
- triazole compound
- antifungal
- triazol
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
- A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
Abstract
Et farmasøytisk preparat om-. fettende: i) hovedsakelig inerte per- ler; hvori angitte perler er belagt med ii) et antifungalt middel som er (-)- (2R-cis)-4-[4-[4-[4-[[-5-(2,4-difluor- fenyl)-tetrahydro-5-(1H-1,2,4-triazol- 1-ylmetyl)furan-3-yl]metoksy]fenyl]-1- piperazinyl]fenyl]-2,4-dihydro-2-[ (S)- l-etyl-2(S)-hydroksypropyl]-3H-1, 2,4- triazol-3-on; iii) et bindemiddel for å muliggjøre at den antifungale forbin- delse adhereres til angitte perler. Preparatet muliggjør at den antifungale forbindelse, som har meget lav vann- løselighet, får forøkt biotilgjengelig- het i pattedyr slik som mennesker.A pharmaceutical composition about. greasy: i) mainly inert beads; wherein said beads are coated with ii) an antifungal agent which is (-) - (2R-cis) -4- [4- [4- [4 - [[- 5- (2,4-difluorophenyl) tetrahydro] -5- (1H-1,2,4-triazol-1-ylmethyl) furan-3-yl] methoxy] phenyl] -1-piperazinyl] phenyl] -2,4-dihydro-2- [(S) -1 -ethyl-2 (S) -hydroxypropyl] -3H-1,2,4-triazol-3-one; iii) a binder to enable the antifungal compound to be adhered to specified beads. The preparation enables the antifungal compound, which has very low water solubility, to have increased bioavailability in mammals such as humans.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US67243296A | 1996-06-28 | 1996-06-28 | |
PCT/US1997/010122 WO1998000116A1 (en) | 1996-06-28 | 1997-06-25 | Oral composition comprising a triazole antifungal compound |
Publications (2)
Publication Number | Publication Date |
---|---|
NO986087D0 NO986087D0 (en) | 1998-12-23 |
NO986087L true NO986087L (en) | 1999-02-26 |
Family
ID=24698529
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO986087A NO986087L (en) | 1996-06-28 | 1998-12-23 | Oral preparation comprising an antifungal triazole compound |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP0914100A1 (en) |
JP (1) | JP2000514059A (en) |
KR (1) | KR20000022294A (en) |
CN (1) | CN1228693A (en) |
AU (1) | AU731704B2 (en) |
BR (1) | BR9710069A (en) |
CA (1) | CA2258683C (en) |
CZ (1) | CZ421498A3 (en) |
HU (1) | HUP9903869A3 (en) |
IL (1) | IL127780A0 (en) |
NO (1) | NO986087L (en) |
NZ (1) | NZ333514A (en) |
PL (1) | PL330864A1 (en) |
SK (1) | SK177598A3 (en) |
TR (1) | TR199802718T2 (en) |
WO (1) | WO1998000116A1 (en) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL129575A (en) * | 1997-03-26 | 2004-06-20 | Janssen Pharmaceutica Nv | Pellets having a core coated with an antifungal and a polymer |
JP2002517431A (en) * | 1998-06-11 | 2002-06-18 | イーエム インダストリーズ インコーポレイテッド | Micro-osmotic pressure controlled drug delivery system |
ID27549A (en) | 1998-07-17 | 2001-04-12 | Janssen Pharmaceutica Nv | PELETS HAVE CORE COATED WITH ANTI MUSHROOMS AND A POLYMER |
ES2157731B1 (en) | 1998-07-21 | 2002-05-01 | Liconsa Liberacion Controlada | ORAL PHARMACEUTICAL PREPARATION OF AN ANTIFUNGIC ACTIVITY COMPOUND AND PROCEDURE FOR PREPARATION. |
US6248363B1 (en) * | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
US7863331B2 (en) | 1999-07-09 | 2011-01-04 | Ethypharm | Pharmaceutical composition containing fenofibrate and method for the preparation thereof |
FR2795961B1 (en) | 1999-07-09 | 2004-05-28 | Ethypharm Lab Prod Ethiques | PHARMACEUTICAL COMPOSITION CONTAINING MICRONIZED FENOFIBRATE, A SURFACTANT AND A BINDING CELLULOSIC DERIVATIVE AND PREPARATION METHOD |
KR100694667B1 (en) * | 1999-12-08 | 2007-03-14 | 동아제약주식회사 | Antifungal compositions containing itraconazole with both improved bioavailability and narrow intra- and inter-individual variation of its absorption |
US6663897B2 (en) * | 2001-02-06 | 2003-12-16 | Dsm Ip Assets B.V. | Oral itraconazole formulations and methods of making the same |
EP1842532A3 (en) * | 2001-02-06 | 2009-04-22 | Stiefel Laboratories, Inc. | Oral sparingly water-soluble antifungal formulations and methods of making the same |
FR2842736B1 (en) | 2002-07-26 | 2005-07-22 | Flamel Tech Sa | ORAL PHARMACEUTICAL FORMULATION IN THE FORM OF A PLURALITY OF MICROCAPSULES FOR PROLONGED RELEASE OF LOW SOLUBLE ACTIVE (S) PRINCIPLE (S) |
ITMI20031096A1 (en) * | 2003-05-30 | 2004-11-30 | Eurand Spa | MICROCAPS FOR COACERVATION CONTAINING DRUG INCORPORATED IN THE COATING POLYMER |
DE10355461A1 (en) | 2003-11-27 | 2005-06-23 | Bayer Healthcare Ag | Solid, high bioavailabilty oral formulations of N-substituted 5-chloro-2-thiophene-carboxamide derivative in hydrophilized form, useful for combating thrombo-embolic diseases |
US11304960B2 (en) | 2009-01-08 | 2022-04-19 | Chandrashekar Giliyar | Steroidal compositions |
US9358241B2 (en) | 2010-11-30 | 2016-06-07 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
US9034858B2 (en) | 2010-11-30 | 2015-05-19 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
US20180153904A1 (en) | 2010-11-30 | 2018-06-07 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
US20120148675A1 (en) | 2010-12-10 | 2012-06-14 | Basawaraj Chickmath | Testosterone undecanoate compositions |
US9498485B2 (en) | 2014-08-28 | 2016-11-22 | Lipocine Inc. | Bioavailable solid state (17-β)-hydroxy-4-androsten-3-one esters |
WO2016033549A2 (en) | 2014-08-28 | 2016-03-03 | Lipocine Inc. | (17-ß)-3-OXOANDROST-4-EN-17-YL TRIDECANOATE COMPOSITIONS AND METHODS OF THEIR PREPARATION AND USE |
CN105949278B (en) * | 2016-03-30 | 2019-12-06 | 南京曼杰生物科技有限公司 | Substituted tetrahydrofuran water-soluble derivative and application thereof |
JP2020503269A (en) | 2016-11-28 | 2020-01-30 | リポカイン インコーポレーテッド | Oral testosterone undecanoate therapy |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5580578A (en) * | 1992-01-27 | 1996-12-03 | Euro-Celtique, S.A. | Controlled release formulations coated with aqueous dispersions of acrylic polymers |
PH30929A (en) * | 1992-09-03 | 1997-12-23 | Janssen Pharmaceutica Nv | Beads having a core coated with an antifungal and a polymer. |
JP2834889B2 (en) * | 1993-12-21 | 1998-12-14 | シェーリング コーポレイション | Tetrahydrofuran antifungal agent |
-
1997
- 1997-06-25 HU HU9903869A patent/HUP9903869A3/en unknown
- 1997-06-25 NZ NZ333514A patent/NZ333514A/en unknown
- 1997-06-25 BR BR9710069A patent/BR9710069A/en not_active IP Right Cessation
- 1997-06-25 TR TR1998/02718T patent/TR199802718T2/en unknown
- 1997-06-25 WO PCT/US1997/010122 patent/WO1998000116A1/en not_active Application Discontinuation
- 1997-06-25 PL PL97330864A patent/PL330864A1/en unknown
- 1997-06-25 EP EP97929927A patent/EP0914100A1/en not_active Ceased
- 1997-06-25 JP JP10504148A patent/JP2000514059A/en not_active Ceased
- 1997-06-25 AU AU33874/97A patent/AU731704B2/en not_active Ceased
- 1997-06-25 CN CN97197432A patent/CN1228693A/en active Pending
- 1997-06-25 SK SK1775-98A patent/SK177598A3/en unknown
- 1997-06-25 IL IL12778097A patent/IL127780A0/en unknown
- 1997-06-25 KR KR1019980710716A patent/KR20000022294A/en not_active Application Discontinuation
- 1997-06-25 CZ CZ984214A patent/CZ421498A3/en unknown
- 1997-06-25 CA CA002258683A patent/CA2258683C/en not_active Expired - Fee Related
-
1998
- 1998-12-23 NO NO986087A patent/NO986087L/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
SK177598A3 (en) | 1999-07-12 |
HUP9903869A3 (en) | 2000-07-28 |
TR199802718T2 (en) | 1999-03-22 |
JP2000514059A (en) | 2000-10-24 |
CA2258683C (en) | 2007-07-31 |
PL330864A1 (en) | 1999-06-07 |
IL127780A0 (en) | 1999-10-28 |
KR20000022294A (en) | 2000-04-25 |
NZ333514A (en) | 2000-05-26 |
BR9710069A (en) | 1999-08-10 |
EP0914100A1 (en) | 1999-05-12 |
CA2258683A1 (en) | 1998-01-08 |
AU731704B2 (en) | 2001-04-05 |
AU3387497A (en) | 1998-01-21 |
HUP9903869A2 (en) | 2000-06-28 |
CN1228693A (en) | 1999-09-15 |
CZ421498A3 (en) | 1999-06-16 |
WO1998000116A1 (en) | 1998-01-08 |
NO986087D0 (en) | 1998-12-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO986087L (en) | Oral preparation comprising an antifungal triazole compound | |
CO4970829A1 (en) | ANTIFUNGAL CRYSTALLINE POLYMORPH | |
AR032279A1 (en) | METHOD FOR INHIBITING ONE OR MORE ACTIVITIES OF PROTEINIC KINASE, COMPOSED OF 2 - PIRAZOLIN-5-ONA PROTEINIC QUINASE INHIBITOR AND PHARMACEUTICAL COMPOSITION THAT INCLUDES IT | |
IE821285L (en) | Triazole antifungal agents | |
KR920006323A (en) | Azacyclic compounds | |
JP2001519346A5 (en) | ||
ES8507541A1 (en) | ((4-(4-(4-Phenyl-1-piperazinyl)phenoxymethyl)-1,3-dioxolan-2-yl)methyl)-1H-imidazoles and 1H-1,2,4-triazoles. | |
JP2002521400A5 (en) | ||
CZ195696A3 (en) | Azoles, process of their preparation and pharmaceutical compositions based thereon | |
AU2931399A (en) | 3-(4-(4-cyanophenyl)thiazol-2-y))-1-(1h-1,2,4-triazol-1-yl) -butan-2-ol derivatives having antifungal activity | |
NZ332699A (en) | Antifungal composition with enhanced bioavailability | |
ES2223893T3 (en) | COMBINATIONS OF FUNGICIDE ACTIVE PRODUCTS. | |
ES8707190A1 (en) | Fungicidal alpha -(alkynylphenyl)azole ethanol compounds | |
RU97115290A (en) | AZOL COMPOUNDS, METHOD FOR OBTAINING THE INDICATED COMPOUNDS AND THEIR APPLICATION | |
BRPI0610423B8 (en) | ((2r, 3r)-3-(4-(4-cyanophenyl)-thiazol-2-yl)-2-(2,4-difluorophenyl)-1-(1h) dihydrogen phosphate mono-lysine salt -1,2,4-triazol-1-yl)butan-2-yloxy)methyl, solvates thereof, pharmaceutical composition comprising the same, use of said salt to treat fungal infections and processes for preparing said salt and sol- vato | |
RU97116580A (en) | TRIAZOLE COMPOUND AND ITS PHARMACOLOGICALLY ACCEPTABLE SALT AND ANTI-FUNGAL COMPOSITION | |
BR0212536A (en) | 3- (phenyl 2,6-disubstituted) -5- [4- or 5-arylthien-2- or -3-yl] -1,2,4-triazoles insecticide | |
DE60205239D1 (en) | AZOL OR TRIAZOL DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS ANTIFUNGAL MEDICAMENTS | |
HUP9802763A2 (en) | Phytomicrobicidal compositions and use thereof | |
EP1120397A3 (en) | Process for preparing triazole derivative | |
ECSP982686A (en) | ANTIFUNGAL CRYSTALLINE POLYFORM | |
ATE17478T1 (en) | 3-SUBSTITUTED 1-AZOLYL-3-METHYL-1-PHENOXY-BUTANE-2-ONES AND -OLS, PROCESSES FOR THEIR PRODUCTION AND THEIR USE AS FUNGICIDES. | |
UY25921A1 (en) | ANTIMYCHOTIC AGENTS DERIVED FROM 1,2,4-TRIAZOLE AND COMPOSITIONS.- | |
WO2004108114B1 (en) | Anti-fungal composition and a process for its manufacture | |
ECSP972133A (en) | ANTI-FUNGAL COMPOSITIONS WITH IMPROVED BIOAVAILABILITY |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |