NO973770L - Rask test for bestemmelse av mengden av funksjonelt inaktivt gen i et genterapi-vektor-preparat - Google Patents
Rask test for bestemmelse av mengden av funksjonelt inaktivt gen i et genterapi-vektor-preparatInfo
- Publication number
- NO973770L NO973770L NO973770A NO973770A NO973770L NO 973770 L NO973770 L NO 973770L NO 973770 A NO973770 A NO 973770A NO 973770 A NO973770 A NO 973770A NO 973770 L NO973770 L NO 973770L
- Authority
- NO
- Norway
- Prior art keywords
- vectors
- gene
- vector
- cells
- tumor
- Prior art date
Links
- 239000013598 vector Substances 0.000 title claims abstract description 143
- 108090000623 proteins and genes Proteins 0.000 title claims description 54
- 238000012360 testing method Methods 0.000 title claims description 47
- 238000001415 gene therapy Methods 0.000 title abstract description 11
- 238000002360 preparation method Methods 0.000 title description 11
- 230000002950 deficient Effects 0.000 claims abstract description 33
- 210000004027 cell Anatomy 0.000 claims description 49
- 238000000034 method Methods 0.000 claims description 34
- 210000004881 tumor cell Anatomy 0.000 claims description 30
- 239000012636 effector Substances 0.000 claims description 27
- 241000701161 unidentified adenovirus Species 0.000 claims description 20
- 239000013642 negative control Substances 0.000 claims description 17
- 239000013641 positive control Substances 0.000 claims description 12
- 108700025716 Tumor Suppressor Genes Proteins 0.000 claims description 9
- 102000044209 Tumor Suppressor Genes Human genes 0.000 claims description 9
- 108700025694 p53 Genes Proteins 0.000 claims description 9
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- 241001430294 unidentified retrovirus Species 0.000 claims description 4
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- 241000700618 Vaccinia virus Species 0.000 claims description 3
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- 239000003795 chemical substances by application Substances 0.000 abstract description 7
- 238000003908 quality control method Methods 0.000 abstract description 6
- 238000003556 assay Methods 0.000 abstract description 2
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- 108700012359 toxins Proteins 0.000 description 5
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- 230000008827 biological function Effects 0.000 description 4
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- 241000212384 Bifora Species 0.000 description 2
- 108020004414 DNA Proteins 0.000 description 2
- 102000016928 DNA-directed DNA polymerase Human genes 0.000 description 2
- 108010014303 DNA-directed DNA polymerase Proteins 0.000 description 2
- 102000052575 Proto-Oncogene Human genes 0.000 description 2
- 108700020978 Proto-Oncogene Proteins 0.000 description 2
- 108010078814 Tumor Suppressor Protein p53 Proteins 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 2
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- 238000001890 transfection Methods 0.000 description 2
- 229920001817 Agar Polymers 0.000 description 1
- 108700028369 Alleles Proteins 0.000 description 1
- 108700020463 BRCA1 Proteins 0.000 description 1
- 102000036365 BRCA1 Human genes 0.000 description 1
- 101150072950 BRCA1 gene Proteins 0.000 description 1
- 101710150820 Cellular tumor antigen p53 Proteins 0.000 description 1
- 102000009016 Cholera Toxin Human genes 0.000 description 1
- 108010049048 Cholera Toxin Proteins 0.000 description 1
- 108091026890 Coding region Proteins 0.000 description 1
- 102000016607 Diphtheria Toxin Human genes 0.000 description 1
- 108010053187 Diphtheria Toxin Proteins 0.000 description 1
- 206010053759 Growth retardation Diseases 0.000 description 1
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- 241001465754 Metazoa Species 0.000 description 1
- 206010073148 Multiple endocrine neoplasia type 2A Diseases 0.000 description 1
- 241000699660 Mus musculus Species 0.000 description 1
- 108091061960 Naked DNA Proteins 0.000 description 1
- 102000048850 Neoplasm Genes Human genes 0.000 description 1
- 108700019961 Neoplasm Genes Proteins 0.000 description 1
- 208000008636 Neoplastic Processes Diseases 0.000 description 1
- 101710160107 Outer membrane protein A Proteins 0.000 description 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 description 1
- 201000005702 Pertussis Diseases 0.000 description 1
- 108010089430 Phosphoproteins Proteins 0.000 description 1
- 102000007982 Phosphoproteins Human genes 0.000 description 1
- 241000920340 Pion Species 0.000 description 1
- 108020004511 Recombinant DNA Proteins 0.000 description 1
- 108010039491 Ricin Proteins 0.000 description 1
- 108010055044 Tetanus Toxin Proteins 0.000 description 1
- 102000006601 Thymidine Kinase Human genes 0.000 description 1
- 108020004440 Thymidine kinase Proteins 0.000 description 1
- 102000015098 Tumor Suppressor Protein p53 Human genes 0.000 description 1
- 108020005202 Viral DNA Proteins 0.000 description 1
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- 230000005907 cancer growth Effects 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
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- 201000010099 disease Diseases 0.000 description 1
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- 238000001647 drug administration Methods 0.000 description 1
- 239000002158 endotoxin Substances 0.000 description 1
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- 238000001476 gene delivery Methods 0.000 description 1
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- 206010051747 multiple endocrine neoplasia Diseases 0.000 description 1
- 238000002703 mutagenesis Methods 0.000 description 1
- 231100000350 mutagenesis Toxicity 0.000 description 1
- 208000025440 neoplasm of neck Diseases 0.000 description 1
- 238000011580 nude mouse model Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
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- 239000013612 plasmid Substances 0.000 description 1
- 230000018855 positive regulation of programmed cell death Effects 0.000 description 1
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- 230000005522 programmed cell death Effects 0.000 description 1
- 230000001902 propagating effect Effects 0.000 description 1
- 208000023958 prostate neoplasm Diseases 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
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- 230000022532 regulation of transcription, DNA-dependent Effects 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
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- 230000000153 supplemental effect Effects 0.000 description 1
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- 229940118376 tetanus toxin Drugs 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/18—Testing for antimicrobial activity of a material
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/390,887 US5637456A (en) | 1995-02-17 | 1995-02-17 | Rapid test for determining the amount of functionally inactive gene in a gene therapy vector preparation |
| PCT/US1996/002042 WO1996025515A1 (en) | 1995-02-17 | 1996-02-14 | A rapid test for determining the amount of functionally inactive gene in a gene therapy vector preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO973770D0 NO973770D0 (no) | 1997-08-15 |
| NO973770L true NO973770L (no) | 1997-10-15 |
Family
ID=23544364
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO973770A NO973770L (no) | 1995-02-17 | 1997-08-15 | Rask test for bestemmelse av mengden av funksjonelt inaktivt gen i et genterapi-vektor-preparat |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US5637456A (pl) |
| EP (1) | EP0811077B1 (pl) |
| JP (1) | JPH11500012A (pl) |
| KR (1) | KR19980702312A (pl) |
| AT (1) | ATE283371T1 (pl) |
| AU (1) | AU700427B2 (pl) |
| BR (1) | BR9607613A (pl) |
| CA (1) | CA2213116A1 (pl) |
| CZ (1) | CZ257597A3 (pl) |
| DE (1) | DE69633913D1 (pl) |
| HU (1) | HUP9802062A3 (pl) |
| NO (1) | NO973770L (pl) |
| NZ (1) | NZ303040A (pl) |
| PL (1) | PL182817B1 (pl) |
| SK (1) | SK283027B6 (pl) |
| UA (1) | UA45492C2 (pl) |
| WO (1) | WO1996025515A1 (pl) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2760009A1 (fr) * | 1997-02-27 | 1998-08-28 | Atochem Elf Sa | Procede de fabrication d'acide acrylique a partir de l'acroleine par reaction redox et l'utilisation d'une composition solide d'oxydes mixtes comme systeme redox dans ladite reaction |
| US7691370B2 (en) | 1998-10-15 | 2010-04-06 | Canji, Inc. | Selectivity replicating viral vector |
| CA2416408A1 (en) * | 2000-07-19 | 2002-01-31 | Regents Of The University Of California | Methods for therapy of neurodegenerative disease of the brain |
| FR2821624B1 (fr) * | 2001-03-01 | 2004-01-02 | Sod Conseils Rech Applic | Nouveau polynucleotide utilisable pour moduler la proliferation des cellules cancereuses |
| US6908560B2 (en) * | 2003-03-12 | 2005-06-21 | Basin Water, Inc. | Zero brine, zero rinse water process for treatment of contaminated drinking water for removal of arsenic |
| EP2208786B1 (en) * | 2005-12-13 | 2018-08-01 | Kyoto University | Nuclear reprogramming factor |
| US20090227032A1 (en) * | 2005-12-13 | 2009-09-10 | Kyoto University | Nuclear reprogramming factor and induced pluripotent stem cells |
| US8278104B2 (en) * | 2005-12-13 | 2012-10-02 | Kyoto University | Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2 |
| US8129187B2 (en) | 2005-12-13 | 2012-03-06 | Kyoto University | Somatic cell reprogramming by retroviral vectors encoding Oct3/4. Klf4, c-Myc and Sox2 |
| US9213999B2 (en) * | 2007-06-15 | 2015-12-15 | Kyoto University | Providing iPSCs to a customer |
| JP2008307007A (ja) * | 2007-06-15 | 2008-12-25 | Bayer Schering Pharma Ag | 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞 |
| CA2695522C (en) * | 2008-05-02 | 2019-01-15 | Kyoto University | Method of nuclear reprogramming |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683202A (en) * | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4975365A (en) * | 1987-05-12 | 1990-12-04 | The John Hopkins University | Assay for measuring DNA cell repair potential |
| US5212057A (en) * | 1988-10-26 | 1993-05-18 | University Of Florida | Biological system for constructing and testing viral vaccines |
| CA2115742A1 (en) * | 1991-08-20 | 1993-03-04 | Ronald G. Crystal | Adenovirus mediated transfer of genes to the gastrointestinal tract |
| FR2688514A1 (fr) * | 1992-03-16 | 1993-09-17 | Centre Nat Rech Scient | Adenovirus recombinants defectifs exprimant des cytokines et medicaments antitumoraux les contenant. |
| FR2704234B1 (fr) * | 1993-04-22 | 1995-07-21 | Centre Nat Rech Scient | Virus recombinants, preparation et utilisation en therapie genique. |
| SK282843B6 (sk) * | 1993-07-13 | 2002-12-03 | Rhone-Poulenc Rorer S. A. | Defektný rekombinantný adenovírus a farmaceutický prostriedok s jeho obsahom |
-
1995
- 1995-02-17 US US08/390,887 patent/US5637456A/en not_active Expired - Fee Related
-
1996
- 1996-02-14 JP JP8525132A patent/JPH11500012A/ja active Pending
- 1996-02-14 UA UA97084262A patent/UA45492C2/uk unknown
- 1996-02-14 NZ NZ303040A patent/NZ303040A/en unknown
- 1996-02-14 HU HU9802062A patent/HUP9802062A3/hu unknown
- 1996-02-14 KR KR1019970705709A patent/KR19980702312A/ko not_active Application Discontinuation
- 1996-02-14 CZ CZ972575A patent/CZ257597A3/cs unknown
- 1996-02-14 EP EP96905510A patent/EP0811077B1/en not_active Expired - Lifetime
- 1996-02-14 SK SK1113-97A patent/SK283027B6/sk unknown
- 1996-02-14 AT AT96905510T patent/ATE283371T1/de not_active IP Right Cessation
- 1996-02-14 BR BR9607613-5A patent/BR9607613A/pt not_active Application Discontinuation
- 1996-02-14 AU AU49248/96A patent/AU700427B2/en not_active Ceased
- 1996-02-14 CA CA002213116A patent/CA2213116A1/en not_active Abandoned
- 1996-02-14 PL PL96321869A patent/PL182817B1/pl not_active IP Right Cessation
- 1996-02-14 DE DE69633913T patent/DE69633913D1/de not_active Expired - Lifetime
- 1996-02-14 WO PCT/US1996/002042 patent/WO1996025515A1/en active IP Right Grant
-
1997
- 1997-08-15 NO NO973770A patent/NO973770L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| ATE283371T1 (de) | 2004-12-15 |
| US5637456A (en) | 1997-06-10 |
| KR19980702312A (ko) | 1998-07-15 |
| CZ257597A3 (cs) | 1998-04-15 |
| PL182817B1 (pl) | 2002-03-29 |
| CA2213116A1 (en) | 1996-08-22 |
| NZ303040A (en) | 1998-07-28 |
| DE69633913D1 (de) | 2004-12-30 |
| JPH11500012A (ja) | 1999-01-06 |
| EP0811077A1 (en) | 1997-12-10 |
| WO1996025515A1 (en) | 1996-08-22 |
| EP0811077B1 (en) | 2004-11-24 |
| SK111397A3 (en) | 1998-04-08 |
| SK283027B6 (sk) | 2003-02-04 |
| AU4924896A (en) | 1996-09-04 |
| BR9607613A (pt) | 1999-11-30 |
| NO973770D0 (no) | 1997-08-15 |
| UA45492C2 (uk) | 2002-04-15 |
| HUP9802062A2 (hu) | 1998-12-28 |
| AU700427B2 (en) | 1999-01-07 |
| PL321869A1 (en) | 1997-12-22 |
| HUP9802062A3 (en) | 2001-08-28 |
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Legal Events
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|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |