NO973231L - New connections - Google Patents
New connectionsInfo
- Publication number
- NO973231L NO973231L NO973231A NO973231A NO973231L NO 973231 L NO973231 L NO 973231L NO 973231 A NO973231 A NO 973231A NO 973231 A NO973231 A NO 973231A NO 973231 L NO973231 L NO 973231L
- Authority
- NO
- Norway
- Prior art keywords
- new connections
- cytokine
- cycloalkyl
- therapy
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Abstract
Denne oppfinnelse vedrører 1-cykloalkyl, 4,5-trisubstituerte imidazolforbind-elser, fremgangsmåte for fremstilling derav, anvendelse derav ved behandling av cytokinformidlede sykdommer og farmasøytiske blandinger for anvendelse i slik terapi.This invention relates to 1-cycloalkyl, 4,5-trisubstituted imidazole compounds, to a process for their preparation, to their use in the treatment of cytokine-mediated diseases and to pharmaceutical compositions for use in such therapy.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US37252195A | 1995-01-12 | 1995-01-12 | |
US37427895A | 1995-01-18 | 1995-01-18 | |
US48334895A | 1995-06-07 | 1995-06-07 | |
PCT/US1996/001094 WO1996021654A1 (en) | 1995-01-12 | 1996-01-11 | Novel compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
NO973231D0 NO973231D0 (en) | 1997-07-11 |
NO973231L true NO973231L (en) | 1997-09-11 |
Family
ID=27409084
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO973231A NO973231L (en) | 1995-01-12 | 1997-07-11 | New connections |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP0802908A4 (en) |
JP (1) | JPH10512264A (en) |
KR (1) | KR19980701374A (en) |
AU (1) | AU709370B2 (en) |
BR (1) | BR9607097A (en) |
CA (1) | CA2210322A1 (en) |
CZ (1) | CZ219597A3 (en) |
FI (1) | FI972970A (en) |
HU (1) | HUP0102677A3 (en) |
MX (1) | MX9705296A (en) |
NO (1) | NO973231L (en) |
NZ (1) | NZ302117A (en) |
PL (1) | PL321292A1 (en) |
WO (1) | WO1996021654A1 (en) |
Families Citing this family (63)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5916891A (en) | 1992-01-13 | 1999-06-29 | Smithkline Beecham Corporation | Pyrimidinyl imidazoles |
US5593992A (en) * | 1993-07-16 | 1997-01-14 | Smithkline Beecham Corporation | Compounds |
US6369068B1 (en) | 1995-06-07 | 2002-04-09 | Smithkline Beecham Corporation | Amino substituted pyrimidine containing compounds |
US5739143A (en) * | 1995-06-07 | 1998-04-14 | Smithkline Beecham Corporation | Imidazole compounds and compositions |
US5658903A (en) * | 1995-06-07 | 1997-08-19 | Smithkline Beecham Corporation | Imidazole compounds, compositions and use |
ZA9610687B (en) | 1995-12-22 | 1997-09-29 | Smithkline Beecham Corp | Novel synthesis. |
AP9700912A0 (en) * | 1996-01-11 | 1997-01-31 | Smithkline Beecham Corp | Novel cycloalkyl substituted imidazoles |
JP2001508395A (en) * | 1996-01-11 | 2001-06-26 | スミスクライン・ビーチャム・コーポレイション | New cycloalkyl-substituted imidazole |
US6046208A (en) * | 1996-01-11 | 2000-04-04 | Smithkline Beecham Corporation | Substituted imidazole compounds |
ZA97175B (en) * | 1996-01-11 | 1997-11-04 | Smithkline Beecham Corp | Novel substituted imidazole compounds. |
NZ327044A (en) * | 1996-01-11 | 2000-01-28 | Smithkline Beecham Corp | Substituted imidazole compounds |
US6096748A (en) | 1996-03-13 | 2000-08-01 | Smithkline Beecham Corporation | Pyrimidine compounds useful in treating cytokine mediated diseases |
JP2000507558A (en) * | 1996-03-25 | 2000-06-20 | スミスクライン・ビーチャム・コーポレイション | Novel treatment for CNS injury |
WO1998007425A1 (en) | 1996-08-21 | 1998-02-26 | Smithkline Beecham Corporation | Imidazole compounds, compositions and use |
US5939069A (en) | 1996-08-23 | 1999-08-17 | University Of Florida | Materials and methods for detection and treatment of immune system dysfunctions |
DE69728688T2 (en) | 1996-11-19 | 2004-08-19 | Amgen Inc., Thousand Oaks | ARYL AND HETEROARYL SUBSTITUTED CONDENSED PYRROLE AS AN ANTI-FLAMMING AGENT |
JP2000514088A (en) * | 1996-11-20 | 2000-10-24 | メルク エンド カンパニー インコーポレーテッド | Triaryl-substituted imidazoles as glucagon antagonists |
US6410729B1 (en) | 1996-12-05 | 2002-06-25 | Amgen Inc. | Substituted pyrimidine compounds and methods of use |
US6096753A (en) * | 1996-12-05 | 2000-08-01 | Amgen Inc. | Substituted pyrimidinone and pyridone compounds and methods of use |
ZA9711092B (en) * | 1996-12-11 | 1999-07-22 | Smithkline Beecham Corp | Novel compounds. |
US6608060B1 (en) | 1996-12-18 | 2003-08-19 | Vertex Pharmaceuticals Incorporated | Inhibitors of p38 |
US6147080A (en) * | 1996-12-18 | 2000-11-14 | Vertex Pharmaceuticals Incorporated | Inhibitors of p38 |
US5945418A (en) * | 1996-12-18 | 1999-08-31 | Vertex Pharmaceuticals Incorporated | Inhibitors of p38 |
US5929076A (en) * | 1997-01-10 | 1999-07-27 | Smithkline Beecham Corporation | Cycloalkyl substituted imidazoles |
US6514977B1 (en) | 1997-05-22 | 2003-02-04 | G.D. Searle & Company | Substituted pyrazoles as p38 kinase inhibitors |
US6979686B1 (en) | 2001-12-07 | 2005-12-27 | Pharmacia Corporation | Substituted pyrazoles as p38 kinase inhibitors |
WO1998052941A1 (en) | 1997-05-22 | 1998-11-26 | G.D. Searle And Co. | PYRAZOLE DERIVATIVES AS p38 KINASE INHIBITORS |
JP2002504909A (en) | 1997-06-13 | 2002-02-12 | スミスクライン・ビーチャム・コーポレイション | New substituted pyrazole and pyrazoline compounds |
EP0994870A4 (en) | 1997-06-19 | 2002-10-23 | Smithkline Beecham | Novel aryloxy substituted pyrimidine imidazole compounds |
AR016294A1 (en) * | 1997-07-02 | 2001-07-04 | Smithkline Beecham Corp | IMIDAZOL SUBSTITUTE COMPOSITE, PHARMACEUTICAL COMPOSITION CONTAINING IT, ITS USE IN THE MANUFACTURE OF A MEDICINAL PRODUCT AND PROCEDURE FOR SUPREPARATION |
TW517055B (en) | 1997-07-02 | 2003-01-11 | Smithkline Beecham Corp | Novel substituted imidazole compounds |
US6489325B1 (en) | 1998-07-01 | 2002-12-03 | Smithkline Beecham Corporation | Substituted imidazole compounds |
WO1999001452A1 (en) | 1997-07-02 | 1999-01-14 | Smithkline Beecham Corporation | Novel cycloalkyl substituted imidazoles |
US7301021B2 (en) | 1997-07-02 | 2007-11-27 | Smithkline Beecham Corporation | Substituted imidazole compounds |
US6562832B1 (en) | 1997-07-02 | 2003-05-13 | Smithkline Beecham Corporation | Substituted imidazole compounds |
US6362193B1 (en) | 1997-10-08 | 2002-03-26 | Smithkline Beecham Corporation | Cycloalkenyl substituted compounds |
EP1021173A1 (en) * | 1997-10-10 | 2000-07-26 | Imperial College Innovations Limited | Use of csaid?tm compounds for the management of uterine contractions |
EP1473292A1 (en) * | 1997-11-03 | 2004-11-03 | Boehringer Ingelheim Pharmaceuticals, Inc. | Aromatic heterocyclic compounds as anti-inflammatory agents |
WO1999023091A1 (en) * | 1997-11-03 | 1999-05-14 | Boehringer Ingelheim Pharmaceuticals, Inc. | Aromatic heterocyclic compounds as anti-inflammatory agents |
US6022884A (en) | 1997-11-07 | 2000-02-08 | Amgen Inc. | Substituted pyridine compounds and methods of use |
WO1999032121A1 (en) | 1997-12-19 | 1999-07-01 | Smithkline Beecham Corporation | Compounds of heteroaryl substituted imidazole, their pharmaceutical compositions and uses |
MY132496A (en) | 1998-05-11 | 2007-10-31 | Vertex Pharma | Inhibitors of p38 |
TR200003472T2 (en) | 1998-05-22 | 2001-09-21 | Smithkline Beecham Corporation | New 2-alkyl substituted imidazole compounds |
US6858617B2 (en) | 1998-05-26 | 2005-02-22 | Smithkline Beecham Corporation | Substituted imidazole compounds |
US6207687B1 (en) * | 1998-07-31 | 2001-03-27 | Merck & Co., Inc. | Substituted imidazoles having cytokine inhibitory activity |
EP1112070B1 (en) | 1998-08-20 | 2004-05-12 | Smithkline Beecham Corporation | Novel substituted triazole compounds |
AU1909200A (en) | 1998-11-04 | 2000-05-22 | Smithkline Beecham Corporation | Pyridin-4-yl or pyrimidin-4-yl substituted pyrazines |
US6239279B1 (en) | 1998-12-16 | 2001-05-29 | Smithkline Beecham Corporation | Synthesis for 4-aryl-5-pyrimidine imidazole substituted derivatives |
US6759410B1 (en) | 1999-11-23 | 2004-07-06 | Smithline Beecham Corporation | 3,4-dihydro-(1H)-quinazolin-2-ones and their use as CSBP/p38 kinase inhibitors |
ATE305787T1 (en) | 1999-11-23 | 2005-10-15 | Smithkline Beecham Corp | 3,4-DIHYDRO-(1H)CHINAZOLINE-2-ONE COMPOUNDS AS CSBP/P39 KINASE INHIBITORS |
DE60020595T2 (en) | 1999-11-23 | 2006-03-16 | Smithkline Beecham Corp. | 3,4-DIHYDRO- (1H) CHINAZOLIN-2-ON COMPOUNDS AS CSBP / P38 KINASE INHIBITORS |
US7235551B2 (en) | 2000-03-02 | 2007-06-26 | Smithkline Beecham Corporation | 1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases |
EP2036891A3 (en) | 2001-06-11 | 2009-03-25 | Vertex Pharmaceuticals Incorporated | Isoquinoline inhibitors of P38 |
HUP0401949A3 (en) * | 2001-10-22 | 2009-07-28 | Mitsubishi Tanabe Pharma Corp | 4-imidazolin-2-one derivatives |
US7268139B2 (en) | 2002-08-29 | 2007-09-11 | Scios, Inc. | Methods of promoting osteogenesis |
JP4675318B2 (en) | 2003-02-10 | 2011-04-20 | バーテックス ファーマシューティカルズ インコーポレイテッド | Process for the preparation of N-heteroaryl-N-aryl-amines by reacting N-arylcarbamates with halo-heteroaryls and similar processes |
WO2005000405A2 (en) * | 2003-06-06 | 2005-01-06 | The Trustees Of The University Of Pennsylvania | P38 kinase inhibitor compositions and methods of use |
EP2396302A2 (en) | 2009-02-13 | 2011-12-21 | Vertex Pharmceuticals Incorporated | Processes for producing phenyl-6-(1-(phenyl)ureido)nicotinamides) |
WO2010093889A2 (en) | 2009-02-13 | 2010-08-19 | Vertex Pharmaceuticals Incorporated | Solid forms of 2-(2, 4-difluorophenyl)-6-(1-(2,6-difluorophenyl)ureido)nicotinamide |
CN113350353A (en) | 2015-03-23 | 2021-09-07 | 墨尔本大学 | Treatment of respiratory diseases |
JP2016193861A (en) * | 2015-03-31 | 2016-11-17 | 国立大学法人山梨大学 | Pharmaceutical compositions for inhibiting mast cell activation |
CA3003433A1 (en) | 2015-10-27 | 2017-05-04 | Children's Hospital Medical Center | Use of mapk inhibitors to reduce loss of hematopoietic stem cells during ex vivo culture and/or genetic manipulation |
CN113272298A (en) * | 2018-11-07 | 2021-08-17 | 墨尔本大学 | Compounds and compositions for the treatment of respiratory diseases |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4725600A (en) * | 1984-07-13 | 1988-02-16 | Fujisawa Pharmaceutical Co., Ltd. | Pyrimidine compounds having activity as a cardiotonic anti-hypertensive cerebrovascular vasodilator and anti-platelet aggregation agent |
JPH0819110B2 (en) * | 1986-06-04 | 1996-02-28 | 富山化学工業株式会社 | Novel imidazole derivative or salt thereof and anti-inflammatory agent, antipyretic analgesic agent or anti-arthritic agent containing them |
IL104369A0 (en) * | 1992-01-13 | 1993-05-13 | Smithkline Beecham Corp | Novel compounds and compositions |
IL110296A (en) * | 1993-07-16 | 1999-12-31 | Smithkline Beecham Corp | Imidazole compounds process for their preparation and pharmaceutical compositions containing them |
US5593992A (en) * | 1993-07-16 | 1997-01-14 | Smithkline Beecham Corporation | Compounds |
US5658903A (en) * | 1995-06-07 | 1997-08-19 | Smithkline Beecham Corporation | Imidazole compounds, compositions and use |
-
1996
- 1996-01-11 MX MX9705296A patent/MX9705296A/en unknown
- 1996-01-11 NZ NZ302117A patent/NZ302117A/en unknown
- 1996-01-11 KR KR1019970704763A patent/KR19980701374A/en not_active Application Discontinuation
- 1996-01-11 WO PCT/US1996/001094 patent/WO1996021654A1/en not_active Application Discontinuation
- 1996-01-11 PL PL96321292A patent/PL321292A1/en unknown
- 1996-01-11 HU HU0102677A patent/HUP0102677A3/en unknown
- 1996-01-11 BR BR9607097A patent/BR9607097A/en not_active Application Discontinuation
- 1996-01-11 JP JP8521882A patent/JPH10512264A/en active Pending
- 1996-01-11 CZ CZ972195A patent/CZ219597A3/en unknown
- 1996-01-11 CA CA002210322A patent/CA2210322A1/en not_active Abandoned
- 1996-01-11 EP EP96903709A patent/EP0802908A4/en not_active Withdrawn
- 1996-01-11 AU AU47704/96A patent/AU709370B2/en not_active Ceased
-
1997
- 1997-07-11 NO NO973231A patent/NO973231L/en not_active Application Discontinuation
- 1997-07-11 FI FI972970A patent/FI972970A/en unknown
Also Published As
Publication number | Publication date |
---|---|
AU4770496A (en) | 1996-07-31 |
HUP0102677A3 (en) | 2002-09-30 |
JPH10512264A (en) | 1998-11-24 |
PL321292A1 (en) | 1997-11-24 |
EP0802908A1 (en) | 1997-10-29 |
AU709370B2 (en) | 1999-08-26 |
BR9607097A (en) | 1997-11-11 |
MX9705296A (en) | 1997-10-31 |
HUP0102677A2 (en) | 2002-04-29 |
EP0802908A4 (en) | 2001-04-11 |
FI972970A (en) | 1997-09-11 |
CA2210322A1 (en) | 1996-07-18 |
NO973231D0 (en) | 1997-07-11 |
FI972970A0 (en) | 1997-07-11 |
WO1996021654A1 (en) | 1996-07-18 |
CZ219597A3 (en) | 1998-03-18 |
NZ302117A (en) | 1999-10-28 |
KR19980701374A (en) | 1998-05-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO973231L (en) | New connections | |
IL125282A (en) | Substituted imidazole compounds, process for their preparation, pharmaceutical compositions containing them and use thereof in the preparation of medicaments for treating cytokine mediated diseases | |
NO991732L (en) | New heterocyclylmethyl substituted pyrazole derivatives | |
LU91145I9 (en) | ||
DE69616749D1 (en) | ARYL SUBSTITUTED 5.5 LINKED AROMATIC NITRO COMPOUNDS AS AN ANTI-FLAMMING AGENTS | |
TR199900046T2 (en) | Substituted pyridines as selective cyclooxygenase-2 inhibitors. | |
CA2272584A1 (en) | Novel substituted pyrazole derivatives for the treatment of cardiocirculatory diseases | |
CA2219115A1 (en) | N-benzyl-3-indoleacetic acids as cyclooxygenase-2-inhibitors and antiinflammatory drugs | |
MX9604378A (en) | Substituted quinoline-2-carboxylic acid amides, their preparation and their use as medicaments, as well as intermediate products thereof. | |
UA48939C2 (en) | Disubstituted furanons, methods for synthesis, pharmaceutical composition, method for treating inflammatory disease, intermediate substances | |
BG101118A (en) | Therapeutical compounds | |
DE69825603D1 (en) | 2,3,5-TRISUBSTITUTED PYRIDINE AS INHIBITORS OF CYCLOOXYGENASE-2 | |
NO972451L (en) | Heterocyclyloxy and thiomethyl-1,2,5-thiadiazolidin-3-one 1,1-dioxides and preparations and process for use thereof | |
ATE212343T1 (en) | 3,4-DIARYL-2-HYDROXY-2,5-DIHYDROFURANES AS PRECURSORS OF COX-2 INHIBITORS | |
DE69825154D1 (en) | PYRIDAZINONE AS INHIBITORS OF CYCLOOXYGENASE-2 | |
NO975662L (en) | Use of 1,2,4-triazole derivatives for the preparation of a drug for the treatment of cancer | |
ATE252897T1 (en) | USE OF P-AMINOPHENOL DERIVATIVES FOR THE PRODUCTION OF PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | |
CA2211320A1 (en) | 5-methanesulfonamido-3h-isobenzofuran-1-ones as inhibitors of cyclooxygenase-2 | |
NO974267D0 (en) | Aminotetraline derivative for the treatment of cardiovascular diseases | |
AP9701142A0 (en) | 4,4-(Disubstituted) cyclohexan-1-ols monomers and related compounds. | |
DK0703781T3 (en) | Use of Efaroxan and its Derivatives for the Preparation of a Drug to Treat Parkinson's Disease | |
AU7230894A (en) | Use of efaxoran and its derivatives for the production of drugs for treating neurodegenerative diseases | |
CA2252401A1 (en) | Pyridinyl-2-cyclopenten-1-ones as selective cyclooxygenase-2 inhibitors | |
AU4788696A (en) | New derivatives of pyridine or pyridazine, process for production thereof and medicaments containing these compounds | |
RU94035756A (en) | Imidazole derivatives as inhibitors of cytokine, methods of synthesis, pharmaceutical composition |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |