NO972892D0 - Bicyclic Low Molecular Growth Thrombin Inhibitors - Google Patents

Bicyclic Low Molecular Growth Thrombin Inhibitors

Info

Publication number
NO972892D0
NO972892D0 NO972892A NO972892A NO972892D0 NO 972892 D0 NO972892 D0 NO 972892D0 NO 972892 A NO972892 A NO 972892A NO 972892 A NO972892 A NO 972892A NO 972892 D0 NO972892 D0 NO 972892D0
Authority
NO
Norway
Prior art keywords
bicyclic
low molecular
thrombin inhibitors
molecular growth
growth
Prior art date
Application number
NO972892A
Other languages
Norwegian (no)
Other versions
NO972892L (en
Inventor
John Gillard
John Dimaio
M Arshad Siddiqui
Patrice Preville
Yves St-Denis
Micheline Tarazi
Sophie Levesque
Benoit Bachand
Jeremy John Edmonds
Annette Marian Doherty
Original Assignee
Iaf Biochem Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9426038.7A external-priority patent/GB9426038D0/en
Priority claimed from GBGB9510265.3A external-priority patent/GB9510265D0/en
Priority claimed from GBGB9510267.9A external-priority patent/GB9510267D0/en
Priority claimed from GBGB9510266.1A external-priority patent/GB9510266D0/en
Application filed by Iaf Biochem Int filed Critical Iaf Biochem Int
Publication of NO972892D0 publication Critical patent/NO972892D0/en
Publication of NO972892L publication Critical patent/NO972892L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
NO972892A 1994-12-22 1997-06-20 Bicyclic Low Molecular Weight Thrombin Inhibitors NO972892L (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GBGB9426038.7A GB9426038D0 (en) 1994-12-22 1994-12-22 Low molecular weight bicyclic thrombin inhibitors
GBGB9503136.5A GB9503136D0 (en) 1994-12-22 1995-02-17 Low molecular weight bicyclic thrombin inhibitors
GBGB9510265.3A GB9510265D0 (en) 1995-05-22 1995-05-22 Low molecular weight diaminobicyclic thrombin inhibitors
GBGB9510267.9A GB9510267D0 (en) 1995-05-22 1995-05-22 Low molecular weight thiobicyclic thrombin inhibitors
GBGB9510266.1A GB9510266D0 (en) 1995-05-22 1995-05-22 Low molecular weight bicyclic thrombin inhibitors
PCT/CA1995/000708 WO1996019483A1 (en) 1994-12-22 1995-12-21 Low molecular weight bicyclic thrombin inhibitors

Publications (2)

Publication Number Publication Date
NO972892D0 true NO972892D0 (en) 1997-06-20
NO972892L NO972892L (en) 1997-08-20

Family

ID=27517273

Family Applications (1)

Application Number Title Priority Date Filing Date
NO972892A NO972892L (en) 1994-12-22 1997-06-20 Bicyclic Low Molecular Weight Thrombin Inhibitors

Country Status (22)

Country Link
EP (1) EP0802916A1 (en)
JP (1) JPH11508535A (en)
CN (1) CN1175259A (en)
AP (1) AP9701004A0 (en)
AU (2) AU4250596A (en)
BG (1) BG101647A (en)
CA (1) CA2208772A1 (en)
CZ (1) CZ189997A3 (en)
EE (1) EE9700113A (en)
FI (1) FI972466A (en)
HU (1) HUT77651A (en)
IL (1) IL116503A0 (en)
IS (1) IS4504A (en)
LV (1) LV12019B (en)
MD (1) MD970253A (en)
MX (1) MX9704718A (en)
NO (1) NO972892L (en)
NZ (1) NZ297360A (en)
OA (1) OA10493A (en)
PL (1) PL320965A1 (en)
SK (1) SK83897A3 (en)
WO (1) WO1996019483A1 (en)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6699869B1 (en) 1995-03-24 2004-03-02 Myriad Genetics Inc. β-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins
US6020331A (en) * 1995-03-24 2000-02-01 Molecumetics, Ltd. β-sheet mimetics and use thereof as protease inhibitors
US6245764B1 (en) 1995-03-24 2001-06-12 Molecumetics Ltd. β-sheet mimetics and use thereof as inhibitors of biologically active peptides or proteins
IT1277405B1 (en) * 1995-08-01 1997-11-10 Menarini Farma Ind BICYCLIC LACTAM DERIVATIVES AS THROMBIN INHIBITORS
IL119466A (en) 1995-11-03 2001-08-26 Akzo Nobel Nv Thrombin inhibitors, their preparation and pharmaceutical compositions containing them
CZ291690B6 (en) * 1996-02-13 2003-05-14 Akzo Nobel N. V. Serine protease inhibitors and pharmaceutical composition
TW442452B (en) 1996-03-01 2001-06-23 Akzo Nobel Nv Serine protease inhibitors having an alkynylamino side chain
TW523513B (en) * 1996-03-01 2003-03-11 Akzo Nobel Nv Serine protease inhibitors
WO1997048706A1 (en) * 1996-06-18 1997-12-24 Warner-Lambert Company Pyrrolo[1,2-a]pyrazine-1,4-dione serine protease inhibitors
EP1661566A3 (en) * 1996-08-05 2008-04-16 Myriad Genetics, Inc. Use of beta-sheet mimetics as protease and kinase inhibitors and as inhibitors of transcription factors
EP0915700B1 (en) * 1996-08-05 2006-03-22 Myriad Genetics, Inc. Use of beta-sheet mimetics as protease and kinase inhibitors and as inhibitors of transcription factors
US6117896A (en) * 1997-02-10 2000-09-12 Molecumetics Ltd. Methods for regulating transcription factors
WO1998009987A1 (en) * 1996-09-06 1998-03-12 Biochem Pharma, Inc. Lactam inhibitors of thrombin
US6194435B1 (en) 1996-10-11 2001-02-27 Cor Therapeutics, Inc. Lactams as selective factor Xa inhibitors
US6063794A (en) 1996-10-11 2000-05-16 Cor Therapeutics Inc. Selective factor Xa inhibitors
US6369080B2 (en) 1996-10-11 2002-04-09 Cor Therapeutics, Inc. Selective factor Xa inhibitors
US6262047B1 (en) 1996-10-11 2001-07-17 Cor Therapeutics, Inc. Selective factor Xa inhibitors
AU5526098A (en) * 1996-12-23 1998-07-17 Biochem Pharma Inc. Bicyclic thrombin inhibitors
EP0975659A1 (en) * 1997-04-14 2000-02-02 Cor Therapeutics, Inc. SELECTIVE FACTOR Xa INHIBITORS
US6204268B1 (en) 1997-04-14 2001-03-20 Cor Therapeutics, Inc Selective factor Xa inhibitors
EP0977773A1 (en) 1997-04-14 2000-02-09 Cor Therapeutics, Inc. SELECTIVE FACTOR Xa INHIBITORS
US6218382B1 (en) 1997-08-11 2001-04-17 Cor Therapeutics, Inc Selective factor Xa inhibitors
US6228854B1 (en) 1997-08-11 2001-05-08 Cor Therapeutics, Inc. Selective factor Xa inhibitors
US6333321B1 (en) 1997-08-11 2001-12-25 Cor Therapeutics, Inc. Selective factor Xa inhibitors
EP1017383A4 (en) * 1997-09-23 2001-11-28 Merck & Co Inc Thrombin inhibitors
DE69810513T2 (en) * 1998-02-12 2004-03-18 Molecumetics, Ltd., Bellevue MIMETIC OF BETA LEAFLET AND METHOD FOR USE THEREOF
US6323219B1 (en) 1998-04-02 2001-11-27 Ortho-Mcneil Pharmaceutical, Inc. Methods for treating immunomediated inflammatory disorders
US8093293B2 (en) 1998-07-06 2012-01-10 Johnson & Johnson Consumer Companies, Inc. Methods for treating skin conditions
US8106094B2 (en) 1998-07-06 2012-01-31 Johnson & Johnson Consumer Companies, Inc. Compositions and methods for treating skin conditions
AU3127900A (en) 1998-12-23 2000-07-31 Du Pont Pharmaceuticals Company Thrombin or factor xa inhibitors
KR20010110422A (en) 1999-01-27 2001-12-13 오르토-맥네일 파마슈티칼, 인코퍼레이티드 Peptidyl heterocyclic ketones useful as tryptase inhibitors
FR2795072B1 (en) * 1999-06-15 2001-07-27 Adir NOVEL BICYCLIC DERIVATIVES OF AMINO-PYRAZINONES, PROCESS FOR THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
CA2401749A1 (en) * 2000-03-23 2001-09-27 Elan Pharmaceuticals, Inc. Compounds and methods to treat alzheimer's disease
US6586418B2 (en) 2000-06-29 2003-07-01 Bristol-Myers Squibb Company Thrombin or factor Xa inhibitors
US8431550B2 (en) 2000-10-27 2013-04-30 Johnson & Johnson Consumer Companies, Inc. Topical anti-cancer compositions and methods of use thereof
FR2818277B1 (en) * 2000-12-14 2003-01-24 Servier Lab NOVEL BICYCLIC DERIVATIVES OF AMINO-PYRAZINONES, PROCESS FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
US7192615B2 (en) 2001-02-28 2007-03-20 J&J Consumer Companies, Inc. Compositions containing legume products
WO2003068237A1 (en) 2002-02-14 2003-08-21 Myriad Genetics, Inc. Beta-sheet mimetics and composition and methods relating thereto
BR0308654A (en) 2002-03-22 2005-02-22 Gpc Biotech Ag Immunosuppressive compounds, methods and related uses
JP6642948B2 (en) 2014-10-06 2020-02-12 コーテクシーミー， インコーポレイテッド Inhibitors of ricindin dipain
JO3637B1 (en) 2015-04-28 2020-08-27 Janssen Sciences Ireland Uc Rsv antiviral pyrazolo- and triazolo-pyrimidine compounds
EP3374352A4 (en) 2015-11-09 2019-10-02 Cortexyme, Inc. Inhibitors of arginine gingipain
EP3512846A4 (en) 2016-09-16 2020-06-10 Cortexyme, Inc. Ketone inhibitors of lysine gingipain
TW201932470A (en) 2017-11-29 2019-08-16 愛爾蘭商健生科學愛爾蘭無限公司 Pyrazolopyrimidines having activity against RSV
CN111670189A (en) 2018-01-31 2020-09-15 爱尔兰詹森科学公司 Cycloalkyl-substituted pyrazolopyrimidines having activity on RSV
AU2019260109B2 (en) 2018-04-23 2023-07-13 Janssen Sciences Ireland Unlimited Company Heteroaromatic compounds having activity against RSV

Also Published As

Publication number Publication date
OA10493A (en) 2002-04-10
HUT77651A (en) 1998-07-28
CZ189997A3 (en) 1998-09-16
WO1996019483A1 (en) 1996-06-27
AP9701004A0 (en) 1997-07-31
CN1175259A (en) 1998-03-04
SK83897A3 (en) 1998-05-06
MD970253A (en) 1999-05-31
BG101647A (en) 1998-03-31
NO972892L (en) 1997-08-20
MX9704718A (en) 1998-06-28
LV12019B (en) 1998-07-20
CA2208772A1 (en) 1996-06-27
FI972466A (en) 1997-08-19
JPH11508535A (en) 1999-07-27
FI972466A0 (en) 1997-06-11
LV12019A (en) 1998-04-20
NZ297360A (en) 2000-03-27
EE9700113A (en) 1997-12-15
IS4504A (en) 1997-06-11
PL320965A1 (en) 1997-11-24
EP0802916A1 (en) 1997-10-29
IL116503A0 (en) 1996-03-31
AU4062895A (en) 1996-07-04
AU715378B2 (en) 2000-02-03
AU4250596A (en) 1996-07-10

Similar Documents

Publication Publication Date Title
NO972892D0 (en) Bicyclic Low Molecular Growth Thrombin Inhibitors
FI973282A0 (en) Thrombin inhibitors
DK0858464T3 (en) Thrombin inhibitors
FI973360A0 (en) New dipeptide amidines as thrombin inhibitors
PT936912E (en) CISTEIN PROTEASE INHIBITORS
DK0956294T3 (en) thrombin inhibitors
EP0927035A4 (en) Thrombin inhibitors
EE9900006A (en) Novel amidine derivatives and their use as thrombin inhibitors
DK0904285T3 (en) Cyclic adhesion inhibitors
BR9707086A (en) Asparta proteinase inhibitors
NO20003814L (en) thrombin inhibitors
GB9613718D0 (en) Thrombin inhibitors
DE69731664D1 (en) thrombin inhibitors
DE69720957T2 (en) ACE INHIBITORS
PT948483E (en) FARNESIL-TRANSFERASE INHIBITORS
GB9426038D0 (en) Low molecular weight bicyclic thrombin inhibitors
NO940997D0 (en) Guanidinyl-substituted heterocyclic thrombin inhibitors
GB9510266D0 (en) Low molecular weight bicyclic thrombin inhibitors
GB9624292D0 (en) Thrombin inhibitors
GB9624319D0 (en) Thrombin inhibitors
GB9625311D0 (en) Thrombin inhibitors
GB9624278D0 (en) Thrombin inhibitors